montelukast and Myringosclerosis

In this study, our aim was to identify the possible effects of montelukast sodium (ML) on the prevention of experimentally induced myringosclerosis.. Twenty-eight female Wistar albino rats were used and they were divided into four groups randomly. Tympanic membranes (TM) of all animals were perforated and then group 1 received no treatment (control group), group 2 was treated with a topical saline solution, group 3 received topically ML and group 4 received orally ML. On the 15th day, all animals were euthanized. Tympanic membranes were evaluated otomicroscopically and histopathologically.. The histopathological findings, compared against a control and saline groups, showed the topically and orally ML groups had statistically significant differences of degree of myringosclerosis (p < 0.002) and median thickness of the TMs (p < 0.001). Suppression of inflammation was statistically significant only in the oral ML treatment group (p < 0.002).. Oral and topically administration of ML reduced myringosclerosis formation in myringotomies rats.

Topics: Acetates; Animals; Cyclopropanes; Cytochrome P-450 CYP1A2 Inducers; Disease Models, Animal; Female; Middle Ear Ventilation; Myringosclerosis; Quinolines; Rats; Rats, Wistar; Sulfides; Tympanic Membrane