montelukast and Multiple-Sclerosis

Montelukast is a leukotriene receptor antagonist that is known to prevent allergic rhinitis and asthma. Blocking the Cysteinyl leukotriene receptor (CysLTR1), one of the primary receptors of leukotrienes, has been demonstrated to be efficacious in ameliorating experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through disrupting chemotaxis of infiltrating T cells. However, the role of CysLTR1 in the pathogenesis of MS is not well understood. Here, we show that MS patients had higher expression of CysLTR1 in the circulation and central nervous system (CNS). The majority of CD4

Topics: Acetates; Adoptive Transfer; Animals; Anti-Inflammatory Agents; Cell Differentiation; Cyclopropanes; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Inflammation; Leukotriene Antagonists; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Multiple Sclerosis; Quinolines; Receptors, Leukotriene; Signal Transduction; Sulfides; Th17 Cells