montelukast and Hypertension

Increasing the affinity of diamidines for AT-rich regions of DNA has long been an important goal of medicinal chemists who wanted to improve the antiparasitic and antifungal properties of that class of derivatives. In recent years it was demonstrated that diamidines could interfere with many other biomolecular targets including ion channels as well as enzymes and modulate some RNA-protein, DNA-protein, and protein-protein interactions. It is therefore not surprising that diamidines now emerge as novel potential drug candidates for the treatment of various diseases, i.a. neurodegenerative disorders, acidosis-related pathological conditions, hypertension, thrombosis, type 2 diabetes, myotonic dystrophy, and cancers. A summary of the most striking results obtained to date in those domains is presented is this review.

Topics: Amidines; Animals; Diabetes Mellitus, Type 2; DNA; Enzymes; Humans; Hypertension; Ion Channels; Myotonic Dystrophy; Neoplasms; Neurodegenerative Diseases; Proteins; RNA; Thrombosis

A case of a 58-year-old woman with Churg-Strauss syndrome is reported. After therapy with steroids clinical improvements were obtained. The discussion concerning the pathogenesis of disease was performed.

Topics: Acetates; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Antihypertensive Agents; Churg-Strauss Syndrome; Combined Modality Therapy; Cyclopropanes; Female; Humans; Hypertension; Methylprednisolone; Middle Aged; Quinolines; Sulfides

Topics: Acetates; Adrenal Cortex Hormones; Aged; Albuterol; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis; Asthma; Cyclopropanes; Depression; Drug Hypersensitivity; Drug Therapy, Combination; Epinephrine; Female; Humans; Hypersensitivity; Hypertension; Methylprednisolone; Omalizumab; Quinolines; Rhinitis; Salmeterol Xinafoate; Seizures; Sulfides; Syncope