montelukast and Gastroesophageal-Reflux

Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.

Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Cyclopropanes; Cytokines; Disease Progression; Double-Blind Method; Female; Forced Expiratory Volume; Gastroesophageal Reflux; Humans; Male; Middle Aged; Obesity; Quinolines; Risk Factors; Sleep Wake Disorders; Sulfides; Theophylline; Treatment Outcome; Vital Capacity