montelukast and Bronchiectasis

Leukotriene receptor antagonists are a new class of drug that were initially identified for use in asthma. As they have an effect on neutrophil mediated inflammation, they may be of benefit in bronchiectasis.. To determine whether leukotriene receptor antagonists have any additive benefit over and above conventional treatment for bronchiectasis (usually consisting of antibiotics and postural drainage).. The Cochrane Airways Group clinical trials register derived from MEDLINE, EMBASE and hand searching of major journals was searched using the terms:Bronchiec* AND leukotrien* OR anti-leuk* OR cysteinyl, Bronchiec* AND monteluk*, Bronchiec* AND zafirluk*. Only randomised, controlled trials were considered. The results of searches were analysed by both authors. No randomised, controlled trials were identified. Further research is required to establish any benefit from the use of leukotriene antagonists in bronchiectasis.

Topics: Acetates; Bronchiectasis; Clinical Trials as Topic; Cyclopropanes; Humans; Indoles; Leukotriene Antagonists; Phenylcarbamates; Placebos; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds