monorden has been researched along with Candidiasis* in 1 studies
1 other study(ies) available for monorden and Candidiasis
| Article | Year |
|---|---|
Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis.
Invasive fungal infections are emerging as serious infectious diseases worldwide. Because of the development of antifungal drug resistance, the limited efficacy of the existing drugs has led to high mortality in patients. The use of the essential eukaryotic chaperone Hsp90, which plays a multifaceted role in drug resistance across diverse pathogenic fungal species, is considered to be a new strategy to mitigate the resistance and counter the threat posed by drug-resistant fungi. Thus, a series of 4,5-diarylisoxazole analogues as fungal Hsp90 inhibitors were designed and synthesized that had potent synergistic effects with fluconazole Topics: Animals; Antifungal Agents; Azoles; Candidiasis; Drug Resistance, Fungal; Fluconazole; Fungi; HSP90 Heat-Shock Proteins; Humans; Mammals; Microbial Sensitivity Tests | 2022 |