monooctanoin and Nausea

monooctanoin has been researched along with Nausea* in 2 studies

Other Studies

2 other study(ies) available for monooctanoin and Nausea

Article	Year
Biochemical and morphological investigations of the toxicity of a Capmul preparation and a bile salt-EDTA solution in patients with bile duct stones. The American journal of gastroenterology, 1984, Volume: 79, Issue:4 Seventeen patients with bile duct calculi were treated alternately with a preparation of glycerol octanoate and a bile salt-EDTA solution via a nasobiliary tube. Of 14 patients (group I), it was necessary to operate on four immediately after irrigation therapy, success resulted from this conservative therapy in eight (57%) cases and two were unchanged. Laboratory investigations showed a decrease in zinc and copper concentrations in the serum. Of the patients 50-60% suffered from vomiting and diarrhea. For three patients (group II), there was an interval of 6-26 days between the end of the therapy and operation. Histological findings in the patients in group I and II subjected to operation included acute ulcerative and chronic inflammation in gallbladder and common bile duct walls. Since the alterations were of minor degree in four of the seven patients who subsequently underwent surgery the risk of irrigation therapy seems to be acceptable. Topics: Aged; Bile Acids and Salts; Caprylates; Cholangitis; Diarrhea; Edetic Acid; Female; Gallbladder Diseases; Gallstones; Glycerides; Hemorrhage; Humans; Male; Middle Aged; Nausea; Ulcer	1984
Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: physical properties and clinical application. Gastroenterology, 1980, Volume: 78, Issue:5 Pt 1 A commercial emulsifying agent consisting largely of glyceryl-l-monooctanoate (monooctanoin) was found to be an excellent cholesterol solvent. In vitro, the agent dissolved mixed cholesterol gallstones more than twice as fast as sodium cholate solutions, which have been previously used for dissolution of retained cholesterol bile duct stones by T-tube infusion. To test clinical efficacy, the solvent was infused, via T-tube, into 12 patients with retained bile duct stones. Some or all of the stones disappeared in 10 patients during biliary tract infusion of monooctanoin for 4--21 days. Stones from the 2 patients whose stones did not disappear were removed surgically and in vitro were found to be insoluble in monooctanoin. Monooctanoin infusions were well tolerated. This digestible solvent appears to be a useful substance for direct physical dissolution of retained bile duct stones by T-tube infusion. Topics: Adult; Aged; Anorexia; Caprylates; Cholesterol; Cholic Acids; Female; Gallstones; Glycerides; Humans; Male; Middle Aged; Nausea; Perfusion; Solubility; Solvents	1980

Article

Year

Biochemical and morphological investigations of the toxicity of a Capmul preparation and a bile salt-EDTA solution in patients with bile duct stones.

The American journal of gastroenterology, 1984, Volume: 79, Issue:4

Seventeen patients with bile duct calculi were treated alternately with a preparation of glycerol octanoate and a bile salt-EDTA solution via a nasobiliary tube. Of 14 patients (group I), it was necessary to operate on four immediately after irrigation therapy, success resulted from this conservative therapy in eight (57%) cases and two were unchanged. Laboratory investigations showed a decrease in zinc and copper concentrations in the serum. Of the patients 50-60% suffered from vomiting and diarrhea. For three patients (group II), there was an interval of 6-26 days between the end of the therapy and operation. Histological findings in the patients in group I and II subjected to operation included acute ulcerative and chronic inflammation in gallbladder and common bile duct walls. Since the alterations were of minor degree in four of the seven patients who subsequently underwent surgery the risk of irrigation therapy seems to be acceptable.

Topics: Aged; Bile Acids and Salts; Caprylates; Cholangitis; Diarrhea; Edetic Acid; Female; Gallbladder Diseases; Gallstones; Glycerides; Hemorrhage; Humans; Male; Middle Aged; Nausea; Ulcer

1984

Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: physical properties and clinical application.

Gastroenterology, 1980, Volume: 78, Issue:5 Pt 1

A commercial emulsifying agent consisting largely of glyceryl-l-monooctanoate (monooctanoin) was found to be an excellent cholesterol solvent. In vitro, the agent dissolved mixed cholesterol gallstones more than twice as fast as sodium cholate solutions, which have been previously used for dissolution of retained cholesterol bile duct stones by T-tube infusion. To test clinical efficacy, the solvent was infused, via T-tube, into 12 patients with retained bile duct stones. Some or all of the stones disappeared in 10 patients during biliary tract infusion of monooctanoin for 4--21 days. Stones from the 2 patients whose stones did not disappear were removed surgically and in vitro were found to be insoluble in monooctanoin. Monooctanoin infusions were well tolerated. This digestible solvent appears to be a useful substance for direct physical dissolution of retained bile duct stones by T-tube infusion.

Topics: Adult; Aged; Anorexia; Caprylates; Cholesterol; Cholic Acids; Female; Gallstones; Glycerides; Humans; Male; Middle Aged; Nausea; Perfusion; Solubility; Solvents

1980