monomethyl-auristatin-e has been researched along with Brain-Neoplasms* in 1 studies
1 other study(ies) available for monomethyl-auristatin-e and Brain-Neoplasms
| Article | Year |
|---|---|
Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma.
We have reported that calcitonin receptor (CTR) is widely expressed in biopsies from the lethal brain tumour glioblastoma by malignant glioma and brain tumour-initiating cells (glioma stem cells) using anti-human CTR antibodies. A monoclonal antibody against an epitope within the extracellular domain of CTR was raised (mAb2C4) and chemically conjugated to either plant ribosome-inactivating proteins (RIPs) dianthin-30 or gelonin, or the drug monomethyl auristatin E (MMAE), and purified. In the high-grade glioma cell line (HGG, representing glioma stem cells) SB2b, in the presence of the triterpene glycoside SO1861, the EC Topics: Antibodies, Monoclonal; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Humans; Oligopeptides; Receptors, Calcitonin; Ribosome Inactivating Proteins, Type 1; Tumor Cells, Cultured | 2017 |