monomethyl-auristatin-e and Body-Weight

monomethyl-auristatin-e has been researched along with Body-Weight* in 1 studies

Other Studies

1 other study(ies) available for monomethyl-auristatin-e and Body-Weight

ArticleYear
Time-to-Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine-Citrulline-Monomethylauristatin E Antibody-Drug Conjugates.
    CPT: pharmacometrics & systems pharmacology, 2019, Volume: 8, Issue:8

    Peripheral neuropathy (PN) is a common long-term debilitating toxicity of antimicrotubule agents. PN was the most frequent adverse event resulting in dose modifications and/or discontinuation of treatment for valine-citrulline-monomethylauristatin E antibody-drug conjugates (ADCs) developed at Genentech. A pooled time-to-event analysis across eight ADCs (~700 patients) was performed to evaluate the relationship between the ADC exposure and the risk for developing a clinically significant (grade ≥ 2) PN. In addition, the impact of demographic and pathophysiological risk factors on the risk for PN was explored. The time-to-event analysis suggested that the development of PN risk increased with ADC exposure, treatment duration, body weight, and previously reported PN. This model can be used to inform clinical strategies such as adaptations to dosing regimen and/or treatment duration as well as inform clinical eligibility to reduce the incidence of grade ≥ 2 PN.

    Topics: Body Weight; Citrulline; Clinical Trials as Topic; Drug Dosage Calculations; Female; Humans; Immunoconjugates; Male; Models, Biological; Neoplasms; Oligopeptides; Peripheral Nervous System Diseases; Time Factors; Valine

2019