monocrotaline has been researched along with Pulmonary Arterial Remodeling in 144 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 87 (60.42) | 24.3611 |
| 2020's | 57 (39.58) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L; Li, F; Sun, X; Wan, Y; Wang, D; Wang, H | 1 |
| Ding, D; He, Y; Jiang, H; Li, X; Liu, X; Xu, Y | 1 |
| Gong, X; Liu, Y; Sheng, Y; Yuan, Y; Zhao, J | 1 |
| Chen, D; Du, GH; Fang, LH; Lyu, Y; Sun, SC; Wang, RR; Wang, SB; Yuan, TY; Zhang, HF | 1 |
| Fu, Q; He, J; Li, M; Peng, J; Tan, S; Tang, M; Tang, Y; Xie, W; Xu, X; Zhang, Q; Zhang, Y; Zheng, Z; Zhu, T | 1 |
| He, X; Hu, L; Li, L; Li, Q; Li, X; Shen, J; Tang, S; Tettey, AT; Wang, Y; Wang, Z; Wu, C; Yin, M; Zhao, C | 1 |
| Bao, C; Chen, J; Han, Y; He, Q; Hu, Y; Liang, S; Luo, A; Nahar, T; Pan, Y; Sun, Y; Tang, H; Wang, H; Xu, Y; Zheng, S | 1 |
| Chen, T; Li, Z; Lu, D; Su, S; Yang, Z; Zhang, D | 1 |
| Aliotta, J; Baird, G; Banerjee, D; Braza, J; Choudhary, G; Harrington, EO; Klinger, JR; Lee, CG; Lu, Q; Nakajima, E; Norbrun, C; Pereira, M; Rounds, S; Sorkhdini, P; Sun, X; Vang, A; Ventetuolo, CE; Yang, AX; Yang, D; Yao, H; Zhou, Y | 1 |
| Guignabert, C; Humbert, M; Kolkhof, P; Lombès, M; Ottaviani, M; Perrot, J; Ponsardin, E; Thuillet, R; Tu, L; Viengchareun, S | 1 |
| Gokcen, T; Inci, EE; Inci, K; Serdar, U; Sevgen, O | 1 |
| Gu, L; Liu, CJ; Liu, HM; Xie, L; Yu, L | 1 |
| Carvalho, MR; Martinez, PF; Ogura, AY; Oliveira-Junior, SA | 1 |
| Dai, P; Deng, Y; Lan, WF; Liao, J; Meng, H; Wu, DD; Xie, SS | 1 |
| Chen, W; Huang, T; Li, W; Liu, J; Peng, H; Song, Q; Wang, X; Xiao, Y; Xiao, Z; Zeng, Y | 1 |
| Li, Y; Liu, Y; Qin, H; Xue, Z; Yang, J; Zhou, M; Zhu, Y | 1 |
| Chen, L; Fan, F; Guan, Y; He, H; Liu, M; Qiu, L; Yang, G; Zheng, F | 1 |
| Li, Y; Su, H; Wang, J; Wang, S; Yan, C; Ying, K; Zhu, H | 1 |
| Bo, Y; Cui, Z; Tianxin, Y; Weiguo, W; Yi, Y; Zhangchi, L | 1 |
| Cai, Q; Chen, L; Li, X; Tang, L; Wang, X; Yang, Y | 1 |
| Chen, J; Chen, X; Feng, J; Liu, Z; Luo, Y; Teng, X; Yan, X; Yang, S; Zhang, L; Zhao, S | 1 |
| Chen, X; Gong, S; Guo, L; Jiang, Z; Li, Y; Peng, T; Tian, Y; Wang, A | 1 |
| Lin, Y; Ma, Y; Wang, C; Zhang, H; Zhang, J | 1 |
| Cai, C; Lin, W; Wu, Y; Xiang, Y; Xu, J; Zeng, C; Zhao, H; Zhu, N | 1 |
| Fan, ZR; Li, L; Li, XZ; Liu, LQ; Ma, KT; Si, JQ; Wang, L; Zhang, LΖ | 1 |
| Feng, W; Li, M; Shi, W; Wang, J; Wang, Q; Yan, X; Zhai, C; Zhang, Q | 1 |
| An, N; Feng, W; Feng, Z; Guan, H; Hu, T; Hu, Y; Liu, J; Mao, Y; Mou, J; Zhang, D | 1 |
| Al-Omran, M; Bhatt, DL; Chowdhury, B; Connelly, KA; Hess, DA; Kabir, MG; Luu, AZ; Luu, VZ; Mazer, CD; Pan, Y; Quan, A; Sabongui, S; Teoh, H; Verma, S | 1 |
| Chen, X; Dong, F; Guo, Z; Peng, Y; Zhang, J; Zhang, S; Zhu, L | 1 |
| Bialesova, L; Bouchard, A; Kinsella, BT; Mulvaney, EP; Reid, HM; Salvail, D | 1 |
| Huang, W; Kong, H; Liu, P; Peng, LY; Xie, WP; Yang, MX; Yu, M; Zhou, H | 1 |
| Avdeev, S; Ergün, S; Ghofrani, HA; Herden, C; Karnati, S; Kosanovic, D; Neupane, B; Pradhan, K; Schermuly, RT; Sydykov, A; Vroom, C | 1 |
| Chen, J; Chen, W; Dong, Q; Feng, P; Huang, W; Li, A; Li, H; Tang, M; Wang, R; Zhao, Y | 1 |
| Antigny, F; Cohen-Kaminsky, S; Courboulin, A; Ghigna, MR; Hautefort, A; Humbert, M; Lambert, M; Le Ribeuz, H; Montani, D; Perros, F | 1 |
| Antunes, MA; Bose, RM; Braga, CL; Caruso-Neves, C; Cruz, FF; Felix, NS; Rocco, PRM; Rocha, NN; Silva, PL; Silva-Aguiar, RP; Teixeira, DE; Vieira, JB | 1 |
| Cheng, TT; Chiu, MH; Fang, SY; Hsu, CH; Huang, CC; Lam, CF; Lin, MW; Roan, JN | 1 |
| Chen, XX; He, JG; Jing, XL; Li, H; Li, L; Li, Y; Meng, XM; Qian, YL; Quan, RL; Wang, PH; Zhou, JJ | 1 |
| Alda, MA; Balancin, M; Batah, SS; Capelozzi, VL; Cruvinel, HR; Fabro, AT; Machado-Rugolo, J; Perdoná Rodrigues da Silva, L; Rodrigues Lopes Roslindo Figueira, R; Silva, PL; Teodoro, WR; Velosa, AP | 1 |
| Deng, Y; Guo, SL; Li, JQ; Wang, F; Wang, Q; Wei, B; Xie, SS; Zhou, YC | 1 |
| Nayeem, MJ; Sato, M; Yamamura, A | 1 |
| Aparicio Cordero, EA; Araujo, AS; Bahr, AC; Baldo, G; Belló-Klein, A; Campos-Carraro, C; Constantin, RL; Donatti, L; Gonzalez, E; Luz de Castro, A; Ortiz, VD; Teixeira, RB; Visioli, F; Zimmer, A | 1 |
| Chuang, KH; Gui, LX; Lin, DC; Lin, MJ; Sham, JSK; Wang, D; Yao, RH; Zheng, SY; Zhu, WJ; Zhu, ZL | 1 |
| Abdul-Salam, VB; Alvarez-Laviada, A; Dries, E; Faggian, G; Gorelik, J; Medvedev, R; Miragoli, M; Rossi, S; Sanchez-Alonso, JL; Schorn, T; Trayanova, N; Wojciak-Stothard, B | 1 |
| Huang, B; Li, L; Li, S; Luo, Y; Tang, C; Xu, S | 1 |
| Guo, L; Jiao, Y; Jin, H; Kim, SC; Li, X; Liu, J; Ma, Y; Shen, L; Zhao, R; Zhou, Z | 1 |
| Cui, X; Dai, C; Feng, H; Guo, X; Jiang, F; Lu, W; Wang, J; Xu, X; Yin, Q; Zhang, J | 1 |
| He, JG; Li, H; Li, L; Li, Y; Meng, XM; Wang, PH; Zhou, JJ | 1 |
| Ghofrani, HA; Grimminger, F; Kojonazarov, B; Novoyatleva, T; Schermuly, RT; Seeger, W; Veeroju, S; Weiss, A; Weissmann, N | 1 |
| Guo, J; Huo, S; Li, S; Lin, L; Luo, P; Lv, J; Peng, L; Shi, W; Wang, M; Yan, D; Zhang, C | 1 |
| Borges, RS; Duarte, GP; Gonzaga-Costa, K; Lahlou, S; Magalhães, PJC; Rebouça, CDSM; Rodrigues-Silva, MJ; Vasconcelos-Silva, AA | 1 |
| Fan, Y; Gao, D; Hao, Y; Li, G; Zhang, Z | 1 |
| Borges, RS; Caetano-Souza, MM; da Silva, JKR; Dos Santos, AA; Duarte, GP; Gonzaga-Costa, K; Lahlou, S; Magalhães, PJC; Martins, CS; Roque, CR; Sousa-Brito, HL; Vasconcelos-Silva, AA | 1 |
| Changcheng, L; Chen, W; Gaofeng, Z; Guoping, T; Luo, J; Min, Y; Minyan, Z; Ouyang, S; Yang, L | 1 |
| Abe, K; Hirano, K; Hirano, M; Hosokawa, K; Imakiire, S; Ishikawa, T; Takana-Ishikawa, M; Tsutsui, H; Watanabe, T; Yoshida, K | 1 |
| Li, X; Liu, H; Lu, X; Ma, W; Ren, F; Tan, X; Wang, S; Yu, L; Zhang, J | 1 |
| Gao, G; Lian, G; Lin, T; Luo, L; Wang, H; Wu, J; Xie, L | 1 |
| Acharya, AP; Bertero, T; Chan, SY; Harvey, LD; Königshoff, M; Little, SR; Mitash, N; Pineda, R; Sun, W; Tai, YY; Tang, Y; Woodcock, CC | 1 |
| Chen, WJ; Chu, PH; Kao, WW; Lai, YJ; Yeh, YH | 1 |
| Fan, J; Lv, Y; Ma, P; Wang, J; Xu, Q; Yan, L; Zhou, R | 1 |
| Dong, S; Du, H; Guo, Z; Li, P; Lu, Y; Qin, Y; Song, J; Wu, H; Zhao, X; Zhou, S; Zhu, N | 1 |
| Harper, R; Hodge, S; Maiolo, S; Reynolds, PN; Tran, HB; Zalewski, PD | 1 |
| Chen, W; Dong, J; Gao, D; Guo, H; Lu, Y; Pan, X; Sun, Y; Xu, D; Xu, Y | 1 |
| Ji, W; Lin, C; Mi, L; Yu, W | 1 |
| Hao, Y; Niu, Y; Sun, T; Wu, F; Xu, Y; Yan, L; Yang, J; Yao, W; Yu, J; Zhang, M; Zhou, R | 1 |
| Abreu, SC; Blanco, NG; Capelozzi, VL; Cruz, FF; Da Silva, JS; de Mendonça, L; Felix, NS; Ferreira, TP; Martins, V; Rocco, PRM; Rocha, N; Silva, PL; Silva, PM; Zapata-Sudo, G | 1 |
| Li, Q; Wang, J; Wu, X; Xie, J; Xu, Y; Yu, J; Zeng, Z; Zhu, X | 1 |
| Higuchi, M; Hikasa, Y; Leong, ZP; Okida, A; Yamano, Y | 1 |
| Fu, N; Liang, Y; Shi, R; Wang, C; Wang, X; Wang, Y; Wei, Z; Xing, J; Yin, S; Zhu, D | 1 |
| Fang, SY; Hsu, CH; Huang, CC; Lam, CF; Luo, CY; Roan, JN; Tsai, HW | 1 |
| Fujita, J; Ishida, A; Ohya, Y; Yamazato, M; Yamazato, Y | 1 |
| Liu, WH; Liu, ZH; Luo, Q; Wang, Y; Xi, QY; Xu, XH; Zhang, HL; Zhao, ZH | 1 |
| Cai, S; Chen, F; Lai, J; Wang, H; Yan, J; Yuan, L; Zheng, S | 1 |
| Chen, J; Gou, D; Li, L; Li, Y; Lin, B; Luo, Y; Qian, Z; Qu, J; Raj, JU | 1 |
| Liu, WZ; Sui, HJ; Tang, FT; Wang, HM; Wang, HX; Zhan, XJ | 1 |
| Chen, XL; Lan, TH; Li, JZ; Lin, DQ; Qiu, HL; Ruan, XM; Wu, YS; Xu, DP | 1 |
| Deighton, J; Dunmore, BJ; Ferrer, E; Hassan, D; Long, L; Moore, S; Morrell, NW; Ormiston, ML; Stewart, DJ; Yang, XD | 1 |
| Cai, Z; Gou, D; Kang, K; Li, J; Pu, J; Qu, B; Shen, J; Shen, L; Tang, Y; Yuan, A; Zhang, X; Zhuang, Q | 1 |
| Belló-Klein, A; Bonetto, JHP; Colombo, R; de Lima-Seolin, BG; Fernandes, RO; Godoy, AEG; Hennemann, MM; Khaper, N; Litvin, IE; Sander da Rosa Araujo, A; Schenkel, PC; Teixeira, RB | 1 |
| Han, H; He, M; Kong, H; Wang, H; Wang, J; Xie, W; Xu, J | 1 |
| Bueno-Beti, C; Hadri, L; Hajjar, RJ; Sassi, Y | 1 |
| Chai, L; Feng, W; Li, C; Li, M; Li, S; Liu, P; Shi, W; Wang, J; Wang, Q; Yan, X; Zhai, C; Zhang, Q; Zhu, Y | 1 |
| Hikasa, Y; Leong, ZP | 1 |
| Chai, L; Chen, Y; Feng, W; Li, M; Li, S; Liu, P; Shi, W; Wang, J; Wang, Q; Yan, X; Zhai, C; Zhang, Q; Zhu, Y | 1 |
| Iesaki, K; Matsumura, Y; Murata, Y; Nakagawa, K; Ohkita, M; Sawano, T; Tanaka, R; Tawa, M; Yamanaka, M; Yano, Y | 1 |
| Abe, K; Hirano, K; Hirano, M; Hirooka, Y; Kuwabara, Y; Sunagawa, K; Tanaka-Ishikawa, M; Tsutsui, H | 1 |
| Bai, P; Fu, J; He, Y; Jia, D; Lyu, A; Lyu, L; Wan, N; Wan, Q; Yu, T; Zuo, C | 1 |
| Chen, F; Chen, L; Meng, H; Wang, H; Yan, J; Yuan, L; Zhan, H; Zhao, J | 1 |
| Duarte, D; Faria-Costa, G; Ferreira-Pinto, MJ; Henriques-Coelho, T; Leite-Moreira, A; Moreira-Gonçalves, D; Negrão, R; Rodrigues, I; Santos, MF; Silva, AF; Sousa-Nunes, F; Tiago Guimarães, J | 1 |
| Huang, CH; Huang, H; Li, YY; Liu, JC; Liu, ZB; Wu, QC; Xu, H; Xu, QR; Zeng, L; Zhou, XL; Zhu, RR | 1 |
| Liu, N; Liu, Y; Sun, Z; Xu, Y; Yanli, L; Yu, F | 1 |
| Fukumitsu, M; Suzuki, K | 1 |
| Chen, FZ; Chen, LW; Shao, SM; Wang, H; Xiang, XH; Yuan, LB; Zhang, SH; Zhu, J | 1 |
| Adams, V; Boekschoten, MV; Bowen, TS; van Norren, K; Vinke, P; Witkamp, RF | 1 |
| Akers, S; Ambrosini, R; Champion, HC; Glickman, S; Haight, D; Lachant, DJ; Meoli, DF; Staicu, S; White, RJ | 1 |
| Chang, Z; Feng, J; Hao, Y; Hu, Z; Jing, Z; Ma, P; Xu, Q; Yan, L; Zhang, M; Zhang, P; Zhou, R; Zhou, W | 1 |
| Xiaolu, W; Yunliang, G | 1 |
| Gubrij, IB; Johnson, LG; Kurten, R; Martin, SR; Pangle, AK | 1 |
| Li, MT; Lu, J; Wang, Q; Zeng, XF; Zhang, LL | 1 |
| Du, J; Liu, S; Qi, Y; Shi, H; Wang, J; Xi, X; Yang, M | 1 |
| Eguchi, M; Ikeda, S; Kawano, H; Koide, Y; Kusumoto, S; Maemura, K; Sato, D | 1 |
| Fei, LM; Sun, GY; Wang, R; Xu, R; Zeng, DS; Zhang, Y; Zhou, SJ; Zhu, QQ | 1 |
| Alemanni, M; Altomare, C; Barile, L; Cornaghi, L; Gobbi, M; Latini, R; Lucchetti, J; Mostacciuolo, G; Rizzetto, R; Rocchetti, M; Ronchi, C; Russo, I; Sala, L; Staszewsky, LI; Zambelli, V; Zaza, A | 1 |
| Chen, M; Lian, G; Lin, T; Luo, L; Wang, H; Xie, L; Xie, Z; Xu, C; Zheng, S | 1 |
| Jasińska-Stroschein, M; Orszulak-Michalak, D; Owczarek, J; Wesołowska, A | 1 |
| Chang, HJ; Kang, WJ; Kim, DH; Lee, SE; Lee, YJ; Shin, JS; Yang, PS | 1 |
| de Figueiredo, SG; Gava, PL; Guimarães, MC; Mauad, H; Pereira, FE; Waichert, ÉJ; Wittmer, VL | 1 |
| Bruce, E; Espejo, A; Francis, J; Horowitz, A; Katovich, MJ; Nair, A; Oswalt, A; Raizada, MK; Rathinasabapathy, A; Shenoy, V; Steckelings, UM; Sumners, C; Unger, T | 1 |
| Adnot, S; Anegon, I; Antigny, F; Bogaard, HJ; Chat, S; Cohen-Kaminsky, S; Dorfmüller, P; Fadel, E; Hautefort, A; Houssaini, A; Humbert, M; Lecerf, F; Péchoux, C; Perros, F; Planté, S; Ranchoux, B; Remy, S; Rucker-Martin, C; Simonneau, G | 1 |
| Chao, S; Cheng, GH; Ju, ZY; Kong, F; Luan, Y; Qi, TG; Wang, J; Xue, X | 1 |
| Ding, M; Fu, E; Jin, F; Lei, J; Li, Z; Liu, S; Ma, F; Qu, Y; Xin, W; Zhang, H | 1 |
| Ba, M; Chen, J; Huang, S; Liu, J; Liu, Z; Wang, J; Xiao, M; Yao, F; Zhang, H; Zhang, R; Zhong, J | 1 |
| Antigny, F; Bentebbal, S; Bogaard, HJ; Dorfmüller, P; Eddahibi, S; Fadel, E; Happé, C; Humbert, M; Izikki, M; Jourdon, P; Lecerf, F; Perros, F; Ranchoux, B; Simonneau, G | 1 |
| Choi, J; Choi, SJ; Choo, MS; Heo, J; Jeong, J; Kang, H; Kim, KH; Kim, SJ; Kim, SW; Kim, Y; Kim, YS; Lee, SW; Lim, J; Oh, W; Oh, YM; Shin, DM; Son, J; Yoo, HJ | 1 |
| Kameshima, S; Kazama, K; Okada, M; Yamawaki, H | 1 |
| Congxin, H; Qingyan, Z; Shengbo, Y; Wei, H; Xiaozhan, W; Xuejun, J; Xule, W; Yanhong, T; Zixuan, D; Zongwen, G | 1 |
| Dai, Z; Guo, Z; Hu, W; Huang, C; Jiang, X; Tang, Y; Wang, X; Yang, B; Yu, S; Zhang, S; Zhao, Q | 1 |
| Azuma, Y; Fukasawa, Y; Ito, M; Kato, T; Kishimoto, Y; Kojima, S; Ohno, K | 1 |
| Gao, YX; Li, S; Li, XW; Yang, JR | 1 |
| Gui, J; Ma, N; Meng, L; Wang, G; Wei, Y | 1 |
| Adcock, IM; Dorfmuller, P; Garfield, BE; Humbert, M; Meng, C; Montani, D; Perros, F; Price, LC; Shao, D; Wort, SJ; Zhu, J | 1 |
| Jiang, Y; Ye, L; Zuo, X | 1 |
| Chen, C; Dong, W; Lin, X; Lv, S; Tong, G; Wang, X; Yang, D; Yang, Y | 1 |
| Cheng, X; Hu, E; Huang, Z; Ma, H; Xiong, C; Zheng, Y | 1 |
| Enikolopov, G; Kaschtanow, A; Michurina, TV; Middendorff, R; Mietens, A; Müller, D; Peters, DM; Reckmann, AN; Saboor, F; Schermuly, RT; Tomczyk, CU; Weissmann, N | 1 |
| Chen, SL; Jiang, XM; Lawrie, A; Li, B; Li, L; Rothman, AMK; Wang, JS; Wang, ZM; Xie, DJ; Zhang, J; Zhou, L | 1 |
| Baldus, S; Behringer, A; Berghausen, EM; Blaschke, F; Caglayan, E; Er, F; Gassanov, N; Kappert, K; Odenthal, M; Rosenkranz, S; Ten Freyhaus, H; Trappiel, M; Wellnhofer, E | 1 |
| Han, D; Ke, R; Li, M; Li, S; Liu, L; Song, Y; Xie, X; Yang, L; Zhang, Y; Zhu, Y | 1 |
| Aliotta, JM; Baird, GL; Del Tatto, M; Dooner, MS; Goldberg, LR; Klinger, JR; Papa, E; Pereira, M; Quesenberry, PJ; Ventetuolo, CE; Wen, S | 1 |
| Han, X; Long, Y; Zhang, X; Zhang, Y; Zhou, Z | 1 |
| Chen, YC; Du, GH; Fang, LH; Lin, YH; Niu, ZR; Wang, DS; Yan, Y; Yuan, TY; Zhang, HF | 1 |
| Ding, X; Fei, G; Li, M; Sun, L; Wang, R; Xu, X; Zhou, S | 1 |
| Liu, Y; Ma, C; Shen, T; Song, S; Yi, Z; Yu, L; Yu, X; Zhang, C; Zhang, H; Zhang, M; Zheng, X; Zhu, D | 1 |
| Fuji, S; Hiramatsu, Y; Hyodo, K; Kubota, M; Matsushita, S; Miyakawa, K; Osaka, M; Sakamoto, H; Tanioka, K; Tokunaga, C | 1 |
| Hu, W; Huang, J; Lv, L; Xiang, Y; Ye, S; Zeng, C; Zhao, X; Zhu, N | 1 |
| Cheng, W; Hu, H; Jiao, S; Li, N; Li, X; Liu, J; Wang, Y; Xu, M; Xue, M; Yan, S; Yin, J; You, S | 1 |
| Lee, BH; Lee, JH; Lim, CJ; Oh, KS; Park, BK; Seo, HW; Yi, KY | 1 |
| Chen, S; Du, J; Du, S; Huang, Y; Jin, H; Liang, C; Liu, D; Ochs, T; Tang, C; Yu, W | 1 |
| Bauer, R; Berndt, A; Betge, S; Franz, M; Grün, K; Jung, C; Lichtenauer, M; Ndongson-Dongmo, B; Neri, D; Petersen, I; Rohm, I; Schulze, PC | 1 |
| Guo, Y; Liu, D; Sun, Y; Wang, X; Xue, Y; Zhao, H | 1 |
| Costa, R; Ducret, T; Ferreira, R; Ferreira-Pinto, MJ; Henriques-Coelho, T; Justino, J; Leite-Moreira, AF; Moreira-Gonçalves, D; Nogueira-Ferreira, R; Quignard, JF; Savineau, JP; Silva, AF; Vitorino, R | 1 |
| Cheng, Y; Gao, H; Gong, B; Hu, J; Huang, L; Li, W; Liu, H; Qiao, C; Wang, X; Zhao, C; Zong, L | 1 |
| Chen, G; He, Y; Jia, D; Liu, H; Lu, A; Zhu, Q; Zuo, C | 1 |
| Gao, L; Li, M; Liu, Y; Shi, W; Wang, J; Wang, Q; Wu, Y; Yan, X; Yang, L; Zhu, Y | 1 |
| Jones, T; Petrusevska, G; Tofovic, SP | 1 |
1 review(s) available for monocrotaline and Pulmonary Arterial Remodeling
| Article | Year |
|---|---|
Mesenchymal stem/stromal cell therapy for pulmonary arterial hypertension: Comprehensive review of preclinical studies.
Topics: Animals; Disease Models, Animal; Hemodynamics; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Arterial Hypertension; Vascular Remodeling | 2019 |
143 other study(ies) available for monocrotaline and Pulmonary Arterial Remodeling
| Article | Year |
|---|---|
Inhibition of HDAC1 alleviates monocrotaline-induced pulmonary arterial remodeling through up-regulation of miR-34a.
Topics: Animals; Benzamides; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Male; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Up-Regulation; Vascular Remodeling | 2021 |
Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension.
Topics: Animals; Apoptosis; Arterial Pressure; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor CHOP; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right; X-Box Binding Protein 1 | 2021 |
Effects of Crocin on CCL2/CCR2 Inflammatory Pathway in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats.
Topics: Animals; Carotenoids; Chemokine CCL2; Disease Models, Animal; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Receptors, CCR2; Vascular Remodeling | 2022 |
Puerarin-V prevents the progression of hypoxia- and monocrotaline-induced pulmonary hypertension in rodent models.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Isoflavones; Mice; Monocrotaline; Phosphatidylinositol 3-Kinases; Pulmonary Artery; Rats; Rodentia; Vascular Remodeling | 2022 |
Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Glucosides; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Sildenafil Citrate; Vascular Remodeling | 2022 |
TPN171H alleviates pulmonary hypertension via inhibiting inflammation in hypoxia and monocrotaline-induced rats.
Topics: Animals; Anti-Inflammatory Agents; Cathepsin B; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Inflammasomes; Inflammation; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Vascular Remodeling | 2022 |
Artemisinin and Its Derivate Alleviate Pulmonary Hypertension and Vasoconstriction in Rodent Models.
Topics: Animals; Artemisinins; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Myocytes, Smooth Muscle; NADPH Oxidases; Nitric Oxide; Rats; Reactive Oxygen Species; Rodentia; Signal Transduction; Vascular Remodeling; Vasoconstriction | 2022 |
Srolo Bzhtang reduces inflammation and vascular remodeling via suppression of the MAPK/NF-κB signaling pathway in rats with pulmonary arterial hypertension.
Topics: Animals; Cytokines; Disease Models, Animal; Hypoxia; Inflammation; Mitogen-Activated Protein Kinases; Monocrotaline; NF-kappa B; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2022 |
Chitinase 3 like 1 contributes to the development of pulmonary vascular remodeling in pulmonary hypertension.
Topics: Animals; Bleomycin; Chitinase-3-Like Protein 1; Humans; Hypertension, Pulmonary; Mice; Mice, Knockout; Mice, Transgenic; Monocrotaline; Vascular Remodeling | 2022 |
Mineralocorticoid Receptor Antagonism by Finerenone Attenuates Established Pulmonary Hypertension in Rats.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Mice; Mineralocorticoid Receptor Antagonists; Monocrotaline; Naphthyridines; Pulmonary Artery; Rats; Receptors, Mineralocorticoid; Vascular Remodeling | 2022 |
Allopurinol treatment reduced vascular remodeling and improved vascular functions in monocrotaline-induced pulmonary hypertensive rats.
Topics: Allopurinol; Animals; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Uric Acid; Vascular Remodeling | 2022 |
[Pulmonary Vascular Remodeling Characteristics of Pulmonary Arterial Hypertension Mouse Model Induced by Left Pneumonectomy and Jugular Vein Injection of Monocrotaline Pyrrole].
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Jugular Veins; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Neointima; Pneumonectomy; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling | 2022 |
Cardioprotective Effect of Resistance Exercise on Left Ventricular Remodeling Associated with Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Resistance Training; Vascular Remodeling; Ventricular Remodeling | 2022 |
PRDX6-mediated pulmonary artery endothelial cell ferroptosis contributes to monocrotaline-induced pulmonary hypertension.
Topics: Animals; Endothelial Cells; Ferroptosis; HMGB1 Protein; Hypertension, Pulmonary; Inflammasomes; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Peroxiredoxin VI; Pulmonary Artery; Rats; Reactive Oxygen Species; Toll-Like Receptor 4; Vascular Remodeling | 2023 |
Shikonin improves pulmonary vascular remodeling in monocrotaline‑induced pulmonary arterial hypertension via regulation of PKM2.
Topics: Animals; Disease Models, Animal; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyruvate Kinase; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2023 |
A modified Fangji Huangqi decoction ameliorates pulmonary artery hypertension via phosphatidylinositide 3-kinases/protein kinase B-mediated regulation of proliferation and apoptosis of smooth muscle cells in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Proliferation; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA; Vascular Remodeling | 2023 |
Maresin-1 protects against pulmonary arterial hypertension by improving mitochondrial homeostasis through ALXR/HSP90α axis.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Heat-Shock Proteins; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Vascular Remodeling | 2023 |
CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Cells, Cultured; Hypertension, Pulmonary; Integrin beta Chains; Male; MicroRNAs; Monocrotaline; Myoblasts, Smooth Muscle; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; RNA, Circular; TOR Serine-Threonine Kinases; Up-Regulation; Vascular Remodeling | 2023 |
Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fibrosis; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2023 |
Canagliflozin ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting pulmonary arterial smooth muscle cell proliferation.
Topics: Animals; Canagliflozin; Cell Proliferation; Glucose; Humans; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling | 2023 |
CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension.
Topics: Animals; CD146 Antigen; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Feedback, Physiological; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Knockout; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Pulmonary Artery; Rats; Severity of Illness Index; Up-Regulation; Vascular Remodeling | 2019 |
eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats.
Topics: Animals; Apoptosis; Cell Proliferation; eIF-2 Kinase; Male; Monocrotaline; Muscle, Smooth; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2019 |
Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition.
Topics: Animals; Endothelial Cells; Glycine; Humans; Hydrogen Sulfide; Monocrotaline; NF-kappa B; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Signal Transduction; Snail Family Transcription Factors; Transforming Growth Factor beta1; Vascular Remodeling | 2019 |
Formononetin attenuates monocrotaline‑induced pulmonary arterial hypertension via inhibiting pulmonary vascular remodeling in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Disease Models, Animal; Hemodynamics; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Isoflavones; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Phosphatidylinositol 3-Kinases; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Survival Rate; Vascular Remodeling | 2019 |
Carbenoxolone decreases monocrotaline‑induced pulmonary inflammation and pulmonary arteriolar remodeling in rats by decreasing the expression of connexins in T lymphocytes.
Topics: Animals; Biopsy; Carbenoxolone; Connexin 43; Connexins; Cytokines; Disease Models, Animal; Echocardiography; Gene Expression Regulation; Hemodynamics; Immunophenotyping; Inflammation Mediators; Male; Monocrotaline; Pneumonia; Pulmonary Fibrosis; Rats; T-Lymphocytes; Vascular Remodeling | 2020 |
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
Topics: Animals; Apoptosis Regulatory Proteins; Immunoblotting; Male; Monocrotaline; Muscle, Smooth, Vascular; Nuclear Proteins; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ubiquitin-Protein Ligases; Vascular Remodeling; YAP-Signaling Proteins | 2020 |
Alginate Oligosaccharide Alleviates Monocrotaline-Induced Pulmonary Hypertension via Anti-Oxidant and Anti-Inflammation Pathways in Rats.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertrophy, Right Ventricular; Injections, Intraperitoneal; Male; Malondialdehyde; Monocrotaline; Pulmonary Arterial Hypertension; Random Allocation; Rats; Vascular Remodeling | 2020 |
The SGLT2 inhibitor empagliflozin reduces mortality and prevents progression in experimental pulmonary hypertension.
Topics: Animals; Benzhydryl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Heart Ventricles; Hemodynamics; Humans; Hypertrophy, Right Ventricular; Lung; Male; Models, Animal; Monocrotaline; Mortality; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Risk Assessment; Sodium-Glucose Transporter 2 Inhibitors; Vascular Remodeling | 2020 |
Chrysin Alleviates Monocrotaline-Induced Pulmonary Hypertension in Rats Through Regulation of Intracellular Calcium Homeostasis in Pulmonary Arterial Smooth Muscle Cells.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Calcium Signaling; Disease Models, Animal; Flavonoids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats, Sprague-Dawley; TRPC Cation Channels; Vascular Remodeling; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2020 |
NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.
Topics: Acetamides; Animals; Antihypertensive Agents; Disease Models, Animal; Heart Ventricles; Hemodynamics; Humans; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrazines; Rats; Rats, Inbred WKY; Receptors, Thromboxane; Sildenafil Citrate; Vascular Remodeling | 2020 |
Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction.
Topics: Animals; Cell Movement; Cell Proliferation; Crown Ethers; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Hypertension, Pulmonary; In Vitro Techniques; MAP Kinase Signaling System; Microfilament Proteins; Monocrotaline; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteopontin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Quinazolines; Rats; Signal Transduction; Vascular Remodeling; Ventricular Function, Right; Ventricular Pressure; Vimentin | 2020 |
Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice.
Topics: Animals; Female; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Monocrotaline; Obesity; Rats; Rats, Zucker; Sex Characteristics; Vascular Remodeling; Ventricular Function, Right | 2020 |
Dihydroartemisinin Attenuates Pulmonary Hypertension Through Inhibition of Pulmonary Vascular Remodeling in Rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antihypertensive Agents; Artemisinins; Arterial Pressure; beta Catenin; Carrier Proteins; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling; Wnt Signaling Pathway | 2020 |
In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression.
Topics: Administration, Inhalation; Animals; Antagomirs; Arterial Pressure; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Male; MicroRNAs; Monocrotaline; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Potassium Channels, Tandem Pore Domain; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Wistar; Signal Transduction; Vascular Remodeling | 2020 |
Niclosamide attenuates lung vascular remodeling in experimental pulmonary arterial hypertension.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Niclosamide; Pulmonary Arterial Hypertension; Rats; Rats, Wistar; Vascular Remodeling | 2020 |
Transplantation of viable mitochondria improves right ventricular performance and pulmonary artery remodeling in rats with pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Vascular Remodeling; Ventricular Remodeling | 2022 |
Nestin represents a potential marker of pulmonary vascular remodeling in pulmonary arterial hypertension associated with congenital heart disease.
Topics: Adolescent; Adult; Aged; Animals; Biomarkers; Child; Child, Preschool; Endothelial Cells; Female; Heart Defects, Congenital; Humans; Lung; Male; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Nestin; Phenotype; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling; Wnt Signaling Pathway; Young Adult | 2020 |
In situ Evidence of Collagen V and Interleukin-6/Interleukin-17 Activation in Vascular Remodeling of Experimental Pulmonary Hypertension.
Topics: Animals; Collagen; Disease Models, Animal; Hypertension, Pulmonary; Interleukin-17; Interleukin-6; Male; Monocrotaline; Rats; Rats, Wistar; Vascular Remodeling | 2020 |
Interferon regulatory factor 7 inhibits rat vascular smooth muscle cell proliferation and inflammation in monocrotaline-induced pulmonary hypertension.
Topics: Activating Transcription Factor 3; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Cyclin D1; Dependovirus; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Inflammation; Interferon Regulatory Factor-7; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Proliferating Cell Nuclear Antigen; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Signal Transduction; Survivin; Up-Regulation; Vascular Remodeling | 2021 |
The Rho kinase 2 (ROCK2)-specific inhibitor KD025 ameliorates the development of pulmonary arterial hypertension.
Topics: Animals; Cell Line; Cell Proliferation; Familial Primary Pulmonary Hypertension; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; rho-Associated Kinases; Up-Regulation; Vascular Remodeling | 2021 |
The progression of pulmonary arterial hypertension induced by monocrotaline is characterized by lung nitrosative and oxidative stress, and impaired pulmonary artery reactivity.
Topics: Animals; Arterial Pressure; Disease Models, Animal; Disease Progression; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Nitrosative Stress; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pulmonary Edema; Rats, Wistar; Receptor, Endothelin A; Time Factors; Vascular Remodeling; Vasodilation | 2021 |
Magnesium Supplementation Attenuates Pulmonary Hypertension via Regulation of Magnesium Transporters.
Topics: Animals; Apoptosis; Cation Transport Proteins; Cell Movement; Cell Proliferation; Down-Regulation; Hypertension, Pulmonary; Hypoxia; Magnesium; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Up-Regulation; Vascular Remodeling | 2021 |
Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension.
Topics: Animals; Calcium; Calcium Signaling; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2021 |
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterial Pressure; Cytokines; Disease Models, Animal; Hypertrophy, Right Ventricular; Inflammation; Inflammation Mediators; Macrophages; Male; Monocrotaline; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Vascular Remodeling | 2021 |
Astragaloside IV blocks monocrotaline‑induced pulmonary arterial hypertension by improving inflammation and pulmonary artery remodeling.
Topics: Animals; Hypertension, Pulmonary; Inflammation; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes; Vascular Remodeling | 2021 |
Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX-5461 on pulmonary arterial hypertension and associated vascular remodelling.
Topics: Animals; Benzothiazoles; Cell Proliferation; Disease Models, Animal; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthyridines; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Polymerase I; Vascular Remodeling | 2021 |
CYLD mediates human pulmonary artery smooth muscle cell dysfunction in congenital heart disease-associated pulmonary arterial hypertension.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Biomarkers; Cell Movement; Cell Proliferation; Child; Child, Preschool; Deubiquitinating Enzyme CYLD; Female; Heart Defects, Congenital; Hemodynamics; Humans; Lung; Male; MAP Kinase Signaling System; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; NF-kappa B; Phenotype; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Serum; Ubiquitin Thiolesterase; Vascular Remodeling; Young Adult | 2021 |
Therapeutic Potential of Regorafenib-A Multikinase Inhibitor in Pulmonary Hypertension.
Topics: Animals; Cell Division; Cell Movement; Drug Evaluation, Preclinical; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hypertension, Pulmonary; Hypoxia; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylurea Compounds; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2021 |
S-Nitroso-L-Cysteine Ameliorated Pulmonary Hypertension in the MCT-Induced Rats through Anti-ROS and Anti-Inflammatory Pathways.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Movement; Collagen; Cysteine; Endoplasmic Reticulum Stress; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; MAP Kinase Signaling System; Matrix Metalloproteinases; Mitophagy; Monocrotaline; Muscle Contraction; Muscle, Smooth; Oxidative Stress; Phosphorylation; Rats, Sprague-Dawley; Reactive Oxygen Species; S-Nitrosothiols; STAT3 Transcription Factor; Vascular Remodeling; Wound Healing | 2021 |
Soluble guanylate cyclase stimulator, trans-4-methoxy-β-nitrostyrene, has a beneficial effect in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterioles; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Signal Transduction; Soluble Guanylyl Cyclase; Styrenes; Vascular Remodeling; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Phenotype and function of macrophage polarization in monocrotaline-induced pulmonary arterial hypertension rat model.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokines; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Macrophages; Male; Mannose Receptor; Monocrotaline; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Phenotype; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling | 2021 |
The soluble guanylate cyclase stimulator, 1-nitro-2-phenylethane, reverses monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Benzene Derivatives; Echocardiography; Endothelium, Vascular; Hemodynamics; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Wistar; Soluble Guanylyl Cyclase; Vascular Remodeling | 2021 |
Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline via the TGF‑β1/p38 MAPK/CREB signaling pathway.
Topics: Animals; Anthocyanins; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Monocrotaline; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Rats; Transforming Growth Factor beta1; Vascular Remodeling | 2021 |
Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats.
Topics: Animals; Antirheumatic Agents; Chloroquine; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 9; Vascular Remodeling | 2021 |
Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function.
Topics: Animals; Cannabidiol; Cell Proliferation; Disease Models, Animal; Glycolysis; Hypoxia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Reactive Oxygen Species; Vascular Remodeling | 2021 |
Influence of atorvastatin on metabolic pattern of rats with pulmonary hypertension.
Topics: Animals; Arterial Pressure; Atorvastatin; Disease Models, Animal; Fatty Acids; Glycolysis; Humans; Hypertension, Pulmonary; Lung; Male; Metabolomics; Monocrotaline; Oxidation-Reduction; Pulmonary Artery; Rats; Vascular Remodeling | 2021 |
Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension.
Topics: Administration, Inhalation; Animals; Benzeneacetamides; Cells, Cultured; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Combinations; Drug Compounding; Enzyme Inhibitors; Glutaminase; Hemodynamics; Humans; Hypertension, Pulmonary; Intracellular Signaling Peptides and Proteins; Lung; Male; Mechanotransduction, Cellular; Monocrotaline; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Sprague-Dawley; Thiadiazoles; Time Factors; Vascular Remodeling; Ventricular Function, Right; Verteporfin; YAP-Signaling Proteins | 2021 |
Lumican deficiency promotes pulmonary arterial remodeling.
Topics: Aged; Animals; Cell Proliferation; Female; Gene Expression Regulation; Humans; Hypoxia; Lumican; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2021 |
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Topics: Actins; Administration, Oral; Animals; Apoptosis; Arterioles; Betaine; Cardiotonic Agents; Disease Models, Animal; Electrocardiography; Heart Failure; Heart Ventricles; Male; Monocrotaline; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Vascular Remodeling | 2021 |
MicroRNA-663 prevents monocrotaline-induced pulmonary arterial hypertension by targeting TGF-β1/smad2/3 signaling.
Topics: Aged; Animals; Becaplermin; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Humans; Male; MicroRNAs; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Vascular Remodeling | 2021 |
Dysregulated zinc and sphingosine-1-phosphate signaling in pulmonary hypertension: Potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Cation Transport Proteins; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Lung; Lysophospholipids; Male; Microvessels; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Vascular Remodeling; Zinc | 2021 |
Valsartan attenuates pulmonary hypertension via suppression of mitogen activated protein kinase signaling and matrix metalloproteinase expression in rodents.
Topics: Animals; Blood Pressure; Cell Proliferation; Extracellular Matrix; Fibrosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; MAP Kinase Signaling System; Matrix Metalloproteinases; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Monocrotaline; Phosphorylation; Rats, Sprague-Dawley; Systole; Transforming Growth Factor beta1; Valsartan; Vascular Remodeling | 2017 |
Mechanisms of N‑acetylcysteine in reducing monocrotaline‑induced pulmonary hypertension in rats: Inhibiting the expression of Nox1 in pulmonary vascular smooth muscle cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Proliferation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidase 1; Pulmonary Artery; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Vascular Remodeling | 2017 |
Protective effects of aloperin on monocroline-induced pulmonary hypertension via regulation of Rho A/Rho kinsase pathway in rats.
Topics: Animals; bcl-2-Associated X Protein; Cardiomegaly; Cyclin-Dependent Kinase Inhibitor p27; Electrocardiography; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Piperidines; Proliferating Cell Nuclear Antigen; Protective Agents; Pulmonary Artery; Quinolizidines; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Vascular Remodeling | 2017 |
Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension.
Topics: Adipose Tissue; Animals; Antigens, CD; Cell Proliferation; Collagen; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Interleukin-6; Lung; Macrophages; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Microtubule-Associated Proteins; Monocrotaline; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Smad1 Protein; Survivin; Vascular Endothelial Growth Factor A; Vascular Remodeling | 2017 |
Dihydromyricetin prevents monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Flavonols; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Vascular Remodeling | 2017 |
Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Indoles; Male; Monocrotaline; Nestin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pulmonary Artery; Pyrroles; Rats, Wistar; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting vascular remodeling in rats.
Topics: Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flavanones; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Male; MAP Kinase Signaling System; Monocrotaline; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2018 |
Exendin-4 improves cardiovascular function and survival in flow-induced pulmonary hypertension.
Topics: Actins; Animals; Antihypertensive Agents; Aorta; Arterial Pressure; Arteriovenous Shunt, Surgical; Cyclic AMP; Disease Models, Animal; Exenatide; Hypertension, Pulmonary; Interleukin-1beta; Male; Monocrotaline; Myosin Heavy Chains; Myosin Type II; Phosphorylation; Pulmonary Artery; Pulmonary Circulation; Rats, Sprague-Dawley; Regional Blood Flow; Vascular Remodeling; Vena Cava, Inferior; Ventricular Function, Right | 2018 |
Intratracheal Administration of Autologous Bone Marrow-Derived Cells Ameliorates Monocrotaline-Induced Pulmonary Vessel Remodeling and Lung Inflammation in Rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone Marrow Transplantation; Cells, Cultured; Cellular Microenvironment; Disease Models, Animal; Interleukin-10; Lung; Macrophage Activation; Macrophages, Alveolar; Male; Monocrotaline; Phenotype; Pneumonia; Rats, Sprague-Dawley; Receptors, Cell Surface; Transplantation, Autologous; Vascular Remodeling | 2018 |
Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Cell Proliferation; Cells, Cultured; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Male; Mevalonic Acid; Monocrotaline; Polyisoprenyl Phosphates; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Signal Transduction; Simvastatin; Vascular Remodeling | 2018 |
Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension by down-regulating HSP70.
Topics: Animals; Grape Seed Extract; HSP70 Heat-Shock Proteins; Hypertension, Pulmonary; Male; Monocrotaline; Proanthocyanidins; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling; Vitis | 2018 |
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Topics: Animals; Becaplermin; Cell Movement; Cell Proliferation; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; HEK293 Cells; Histone Deacetylases; Humans; Hypertension, Pulmonary; Male; MicroRNAs; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Pulmonary Artery; Rats, Sprague-Dawley; Repressor Proteins; Signal Transduction; Vascular Remodeling | 2018 |
Cystamine slows but not inverses the progression of monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterioles; Cystamine; Heart Septum; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pressure; Protein Glutamine gamma Glutamyltransferase 2; Pulmonary Artery; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Survival Analysis; Transglutaminases; Vascular Remodeling | 2018 |
3,7-Bis(2-hydroxyethyl)icaritin, a potent inhibitor of phosphodiesterase-5, prevents monocrotaline-induced pulmonary arterial hypertension via NO/cGMP activation in rats.
Topics: Animals; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelin-1; Flavonoids; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2018 |
A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Bone Morphogenetic Protein Receptors, Type II; Cell Movement; Cell Proliferation; Cell Shape; Disease Models, Animal; Endothelial Cells; Exosomes; Humans; Hypertension, Pulmonary; Lentivirus; Lung; Male; Monocrotaline; Mutation; Myocytes, Smooth Muscle; Protein Transport; Pulmonary Artery; Rats, Sprague-Dawley; Tumor Protein, Translationally-Controlled 1; Vascular Remodeling | 2018 |
MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3 signaling pathways.
Topics: Animals; Apoptosis; Cells, Cultured; Down-Regulation; Gene Expression Regulation; Hypertension, Pulmonary; Interleukin-6; Male; MicroRNAs; Monocrotaline; Pulmonary Artery; Rats; Signal Transduction; STAT3 Transcription Factor; Transforming Growth Factor beta; Vascular Remodeling | 2018 |
Bucindolol attenuates the vascular remodeling of pulmonary arteries by modulating the expression of the endothelin-1 A receptor in rats with pulmonary arterial hypertension.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Echocardiography; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type III; Oxidative Stress; Propanolamines; Pulmonary Artery; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Vascular Remodeling | 2018 |
Dipeptidyl peptidase IV (DPP-4) inhibition alleviates pulmonary arterial remodeling in experimental pulmonary hypertension.
Topics: Animals; Becaplermin; Bleomycin; Cell Movement; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Hypertension, Pulmonary; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Myocytes, Smooth Muscle; PTEN Phosphohydrolase; Random Allocation; Rats, Wistar; Sitagliptin Phosphate; Tunica Intima; Vascular Remodeling; Ventricular Remodeling | 2018 |
Pulmonary Artery Hypertension Model in Rats by Monocrotaline Administration.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Dysfunction, Right | 2018 |
Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Enzyme Activation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; NF-kappa B; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2018 |
Effects of toceranib compared with sorafenib on monocrotaline-induced pulmonary arterial hypertension and cardiopulmonary remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Autophagy; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Monocrotaline; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pulmonary Artery; Pyrroles; Rats, Wistar; Signal Transduction; Sorafenib; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Hypertension, Pulmonary; Male; Monocrotaline; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Sprague-Dawley; Resveratrol; Signal Transduction; Stilbenes; Vascular Remodeling | 2018 |
Effects of Beet Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats.
Topics: Animals; Arterial Pressure; Beta vulgaris; Dietary Supplements; Disease Models, Animal; Fruit and Vegetable Juices; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Plant Roots; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right | 2019 |
Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imines; Male; Mice, Knockout; Monocrotaline; Pulmonary Artery; Pyridines; Rats, Sprague-Dawley; Receptor, PAR-1; Thrombin; Vascular Remodeling; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-β1 Signaling.
Topics: Animals; Caspase Inhibitors; Cysteine Endopeptidases; Extracellular Matrix Proteins; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Inflammation; Lung; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Middle Aged; Monocrotaline; Pyrroles; Rats; Severity of Illness Index; Signal Transduction; Transforming Growth Factor beta1; Vascular Remodeling | 2019 |
Grape seed proanthocyanidin inhibits monocrotaline-induced pulmonary arterial hypertension via attenuating inflammation: in vivo and in vitro studies.
Topics: Animals; Calcium; Cell Proliferation; Cells, Cultured; Grape Seed Extract; Heart Failure; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type III; Pneumonia; Proanthocyanidins; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Vascular Remodeling | 2019 |
Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition.
Topics: Animals; Beer; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Enzymologic; Hypertension, Pulmonary; Male; Monocrotaline; Propiophenones; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Vascular Remodeling | 2019 |
NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy.
Topics: Animals; Autophagy; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hemodynamics; Histone-Lysine N-Methyltransferase; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling | 2019 |
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Gene Expression Regulation; Gene Ontology; Hypertension, Pulmonary; Metformin; Microarray Analysis; Monocrotaline; Pulmonary Artery; Rats, Wistar; RNA, Long Noncoding; RNA, Messenger; Vascular Remodeling | 2019 |
[Effects of apple polyphenols on monocrotaline-induced pulmonary vascular remodeling in rats and its mechanism].
Topics: Animals; Calcium; Cyclooxygenase 2; Cytokines; Malus; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Polyphenols; Pulmonary Artery; Random Allocation; Rats; Vascular Remodeling | 2019 |
Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Female; Fibrosis; Heart; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Skeletal; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling; Ventricular Function, Right | 2019 |
Combination therapy improves vascular volume in female rats with pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Drug Therapy, Combination; Echocardiography; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Phenylpropionates; Pneumonectomy; Pulmonary Artery; Pyridazines; Rats; Rats, Sprague-Dawley; Tadalafil; Vascular Remodeling; Vasoconstriction; Ventricular Dysfunction, Right; X-Ray Microtomography | 2019 |
Protective effects of 18β-glycyrrhetinic acid on pulmonary arterial hypertension via regulation of Rho A/Rho kinsase pathway.
Topics: Animals; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation; Glycyrrhetinic Acid; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Smooth Muscle; Protective Agents; Protein Phosphatase 1; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vascular Remodeling | 2019 |
Letter by Wang and Guo regarding article Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Topics: Humans; Hypertension, Pulmonary; Metformin; Monocrotaline; Pulmonary Artery; RNA, Long Noncoding; RNA, Messenger; Vascular Remodeling | 2019 |
Attenuation of monocrotaline-induced pulmonary hypertension by luminal adeno-associated virus serotype 9 gene transfer of prostacyclin synthase.
Topics: Animals; Cytochrome P-450 Enzyme System; Dependovirus; Enzyme Induction; Gene Expression; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Intramolecular Oxidoreductases; Monocrotaline; Promoter Regions, Genetic; Rats, Inbred F344; Rats, Sprague-Dawley; Transduction, Genetic; Vascular Remodeling | 2014 |
Preventive and remedial application of etanercept attenuate monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Anti-Infective Agents; Arterial Pressure; Disease Models, Animal; Etanercept; Hypertension, Pulmonary; Interleukin-6; Lung; Male; Monocrotaline; Pulmonary Artery; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2016 |
Serum-glucocorticoid regulated kinase 1 regulates macrophage recruitment and activation contributing to monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Hypertension, Pulmonary; Immediate-Early Proteins; Inflammation; Macrophages; Mice; Mice, Knockout; Monocrotaline; Myocytes, Smooth Muscle; Protein Serine-Threonine Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vascular Remodeling | 2014 |
Adipose-derived regenerative cell therapy inhibits the progression of monocrotaline-induced pulmonary hypertension in rats.
Topics: Adipose Tissue; Animals; Disease Progression; Gene Expression Profiling; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Rats, Wistar; Regenerative Medicine; RNA, Messenger; Stem Cell Transplantation; Survival Analysis; Vascular Remodeling; Weight Gain | 2014 |
Plasmid-based short hairpin RNA against connective tissue growth factor attenuated monocrotaline-induced pulmonary vascular remodeling in rats.
Topics: Animals; Connective Tissue Growth Factor; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Vascular Remodeling | 2014 |
Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension.
Topics: Acetanilides; Animals; Calcium Signaling; Collagen; Disease Models, Animal; Fibrosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Membrane Potentials; Monocrotaline; Myocytes, Cardiac; Myosin Heavy Chains; Piperazines; Pulmonary Artery; Ranolazine; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Sodium Channels; Time Factors; Vascular Remodeling; Vascular Resistance; Ventricular Function, Right; Ventricular Remodeling | 2014 |
Adipose-derived stem cells attenuate pulmonary arterial hypertension and ameliorate pulmonary arterial remodeling in monocrotaline-induced pulmonary hypertensive rats.
Topics: Adipose Tissue; Alkaloids; Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Treatment Outcome; Vascular Remodeling | 2015 |
Rosuvastatin, sildenafil and their combination in monocrotaline-induced pulmonary hypertension in rat.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Biomarkers; Cholesterol, HDL; Disease Models, Animal; Drug Therapy, Combination; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Natriuretic Peptide, Brain; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Purines; Pyrimidines; Rats, Wistar; Rosuvastatin Calcium; Sildenafil Citrate; Sulfonamides; Time Factors; Vascular Endothelial Growth Factor A; Vascular Remodeling; Vasodilator Agents; Ventricular Function, Right; Ventricular Pressure | 2014 |
Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Glycyrrhizic Acid; HMGB1 Protein; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle, Smooth, Vascular; Pneumonia; Pulmonary Artery; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right | 2014 |
Effects of captopril on cardiovascular reflexes and respiratory mechanisms in rats submitted to monocrotaline-induced pulmonary arterial hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Baroreflex; Captopril; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Wistar; Vascular Remodeling | 2015 |
Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imidazoles; Lung; Male; Monocrotaline; Myocardium; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pulmonary Fibrosis; Pyridines; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Signal Transduction; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2015 |
Endothelial-to-mesenchymal transition in pulmonary hypertension.
Topics: Actins; Animals; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Cell Movement; Cell Transdifferentiation; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Gene Expression Profiling; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Mesoderm; Monocrotaline; Mutation; Rats; RNA, Messenger; Sirolimus; Vascular Remodeling; Vimentin | 2015 |
Therapeutic effects of baicalin on monocrotaline-induced pulmonary arterial hypertension by inhibiting inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cytokines; Disease Models, Animal; Flavonoids; Hypertension, Pulmonary; Immunohistochemistry; Lung; Monocrotaline; Pulmonary Artery; Rats, Wistar; Vascular Remodeling | 2015 |
Calorie Restriction Attenuates Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
Topics: Acetylation; Adenoviridae; Animals; Arterial Pressure; Caloric Restriction; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Genetic Vectors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Time Factors; Transduction, Genetic; Vascular Remodeling; Vasodilation; Vasodilator Agents | 2015 |
Transfer of human hepatocyte growth factor reduces inflammation and prevents pulmonary arterial remodeling in monocrotaline-induced.
Topics: Animals; Cell-Derived Microparticles; Endothelium, Vascular; Gene Transfer Techniques; Hepatocyte Growth Factor; Humans; Hypertension, Pulmonary; Inflammation; Interleukin-6; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2014 |
Nebivolol for improving endothelial dysfunction, pulmonary vascular remodeling, and right heart function in pulmonary hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Benzopyrans; Cell Communication; Cell Culture Techniques; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Ethanolamines; Humans; Hypertension, Pulmonary; Male; Metoprolol; Monocrotaline; Myocytes, Smooth Muscle; Nebivolol; Pulmonary Artery; Rats; Rats, Wistar; Vascular Remodeling | 2015 |
The Therapeutic Effects of Human Mesenchymal Stem Cells Primed with Sphingosine-1 Phosphate on Pulmonary Artery Hypertension.
Topics: Animals; Antimicrobial Cationic Peptides; Blood Pressure; Cathelicidins; Cell Movement; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Humans; Hypertension, Pulmonary; Lysophospholipids; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Monocrotaline; Neovascularization, Physiologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred Lew; Signal Transduction; Sphingosine; Transcription Factors; Vascular Remodeling | 2015 |
Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling.
Topics: Animals; Elongation Factor 2 Kinase; Hypertension, Pulmonary; Male; Matrix Metalloproteinase 2; Monocrotaline; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Pyridines; Pyrimidines; Rats; Rats, Wistar; Reactive Oxygen Species; Vascular Remodeling | 2015 |
Beneficial Effects of Renal Denervation on Pulmonary Vascular Remodeling in Experimental Pulmonary Artery Hypertension.
Topics: Angiotensin II; Animals; Collagen; Dimethylformamide; Dinoprostone; Dogs; Echocardiography; Electrocardiography; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Female; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Kidney; Lung; Male; Monocrotaline; Neurotransmitter Agents; Random Allocation; Renal Artery; Renin-Angiotensin System; Sympathectomy; Vascular Remodeling | 2015 |
[Beneficial effects of renal denervation on pulmonary vascular remodeling in experimental pulmonary artery hypertension].
Topics: Angiotensin II; Animals; Blood Pressure; Denervation; Dogs; Echocardiography; Endothelin-1; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Kidney; Lung; Monocrotaline; Pulmonary Artery; Sympathectomy; Vascular Remodeling | 2015 |
Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Cell Proliferation; Disease Models, Animal; Hydrogen; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NFATC Transcription Factors; Phosphorylation; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Vascular Remodeling | 2015 |
[Effect of sesamin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary hypertension].
Topics: Animals; Dioxoles; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Hypertension, Pulmonary; Lignans; Lung; Male; Membrane Glycoproteins; Monocrotaline; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2015 |
Activation of the phosphatidylinositol 3-kinase/Akt pathway is involved in lipocalin-2-promoted human pulmonary artery smooth muscle cell proliferation.
Topics: Acute-Phase Proteins; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Humans; Hypertension, Pulmonary; Lipocalin-2; Lipocalins; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Up-Regulation; Vascular Remodeling | 2015 |
Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspase 3; Cells, Cultured; Cytokines; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; I-kappa B Proteins; Inflammation Mediators; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pulmonary Artery; Rats; Rats, Wistar; Signal Transduction; Transcription Factor RelA; Vascular Remodeling | 2015 |
Farnesoid-X-receptor expression in monocrotaline-induced pulmonary arterial hypertension and right heart failure.
Topics: Animals; Disease Models, Animal; Gene Expression; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Vascular Remodeling; Ventricular Remodeling | 2015 |
Tetrandrine prevents monocrotaline-induced pulmonary arterial hypertension in rats through regulation of the protein expression of inducible nitric oxide synthase and cyclic guanosine monophosphate-dependent protein kinase type 1.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Benzylisoquinolines; Catalase; Cell Proliferation; Cyclic GMP-Dependent Protein Kinase Type I; Disease Models, Animal; Glutathione; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Oxidative Stress; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase; Time Factors; Vascular Remodeling; Ventricular Remodeling | 2016 |
Inhibition of FGFR Signaling With PD173074 Ameliorates Monocrotaline-induced Pulmonary Arterial Hypertension and Rescues BMPR-II Expression.
Topics: Adolescent; Adult; Animals; Apoptosis; Arterioles; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblast Growth Factor 2; Heart Ventricles; Hemodynamics; Humans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; Signal Transduction; Smad Proteins, Receptor-Regulated; Time Factors; Vascular Remodeling; Young Adult | 2015 |
Nestin-expressing vascular wall cells drive development of pulmonary hypertension.
Topics: Animals; Calcium-Binding Proteins; Calponins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Green Fluorescent Proteins; Humans; Hypertension, Pulmonary; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Monocrotaline; Muscle, Smooth, Vascular; Nestin; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Vascular Remodeling | 2016 |
Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline.
Topics: Action Potentials; Animals; Arterial Pressure; Cell Proliferation; Disease Models, Animal; Dogs; Gene Expression Regulation; Hypertension, Pulmonary; Monocrotaline; Neural Conduction; Pulmonary Artery; RNA, Messenger; Sympathectomy; Sympathetic Nervous System; Time Factors; Vascular Remodeling; Vascular Resistance; Vasoconstriction | 2015 |
Pioglitazone alleviates cardiac and vascular remodelling and improves survival in monocrotaline induced pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages, Alveolar; Male; Monocrotaline; Myocytes, Cardiac; Natriuretic Peptide, Brain; Osteopontin; Pioglitazone; PPAR gamma; Pulmonary Artery; Rats, Sprague-Dawley; Thiazolidinediones; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2016 |
Activation of AMPK Prevents Monocrotaline-Induced Extracellular Matrix Remodeling of Pulmonary Artery.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Enzyme Activation; Extracellular Matrix; Hypertension, Pulmonary; Male; Matrix Metalloproteinase 2; Metformin; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Vascular Remodeling | 2016 |
Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice.
Topics: Animals; Case-Control Studies; Cell-Derived Microparticles; Cells, Cultured; Disease Models, Animal; Exosomes; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Pulmonary Artery; Vascular Remodeling | 2016 |
Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Chalcone; Deoxyguanosine; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Male; Malondialdehyde; Monocrotaline; Oxidative Stress; Quinones; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Vascular Remodeling | 2016 |
Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model.
Topics: Animals; Apoptosis; Blood Pressure; Caffeic Acids; Drugs, Chinese Herbal; Heart; Hypertension, Pulmonary; Lactates; Lung; Male; Monocrotaline; Myocardium; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Vascular Remodeling | 2016 |
Microrna-26b attenuates monocrotaline-induced pulmonary vascular remodeling via targeting connective tissue growth factor (CTGF) and cyclin D1 (CCND1).
Topics: 3' Untranslated Regions; Animals; Cell Cycle; Cells, Cultured; Connective Tissue Growth Factor; Cyclin D1; Gene Expression Profiling; Gene Expression Regulation; Male; MicroRNAs; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; RNA Interference; RNA, Small Interfering; Vascular Remodeling | 2016 |
The role of PDGF-B/TGF-β1/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling.
Topics: Animals; Cattle; Cell Hypoxia; Down-Regulation; Endothelial Cells; Endothelium; Hypertension, Pulmonary; Imatinib Mesylate; Immunoprecipitation; Mesoderm; Monocrotaline; Neprilysin; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Rats; Signal Transduction; Transforming Growth Factor beta1; Vascular Remodeling | 2016 |
Association between endothelial function and micro-vascular remodeling measured by synchrotron radiation pulmonary micro-angiography in pulmonary arterial hypertension.
Topics: Angiography; Animals; Arterial Pressure; Arterioles; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Synchrotrons; Thrombosis; Vascular Endothelial Growth Factor A; Vascular Remodeling | 2016 |
Thymoquinone attenuates monocrotaline-induced pulmonary artery hypertension via inhibiting pulmonary arterial remodeling in rats.
Topics: Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Benzoquinones; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome; Vascular Remodeling | 2016 |
Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Endothelium, Vascular; Genetic Therapy; Hypertension, Pulmonary; Injections, Spinal; Lung; Mitochondrial Proton-Translocating ATPases; Monocrotaline; Neutrophil Infiltration; Oxidative Phosphorylation Coupling Factors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Vascular Remodeling; Ventricular Dysfunction, Right | 2016 |
A urotensin II receptor antagonist, KR36676, decreases vascular remodeling and inflammation in experimental pulmonary hypertension.
Topics: Acetamides; Animals; Anti-Inflammatory Agents; Benzoxazines; Collagen; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; MAP Kinase Signaling System; Monocrotaline; NF-kappa B; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2016 |
Sulfur Dioxide Protects Against Collagen Accumulation in Pulmonary Artery in Association With Downregulation of the Transforming Growth Factor β1/Smad Pathway in Pulmonary Hypertensive Rats.
Topics: Animals; Aspartate Aminotransferases; Cells, Cultured; Collagen; Disease Models, Animal; Down-Regulation; Fibroblasts; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Sulfur Dioxide; Transforming Growth Factor beta1; Vascular Remodeling | 2016 |
Lung tissue remodelling in MCT-induced pulmonary hypertension: a proposal for a novel scoring system and changes in extracellular matrix and fibrosis associated gene expression.
Topics: Actins; Animals; Disease Models, Animal; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Fibrosis; Gene Expression Profiling; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Lung; Monocrotaline; Oligonucleotide Array Sequence Analysis; Rats, Sprague-Dawley; Severity of Illness Index; Tenascin; Vascular Remodeling | 2016 |
Inhibition of endocan attenuates monocrotaline-induced connective tissue disease related pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Cells, Cultured; Connective Tissue; Disease Models, Animal; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Proteoglycans; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2017 |
HMGB1 down-regulation mediates terameprocol vascular anti-proliferative effect in experimental pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Hemodynamics; HMGB1 Protein; Hypertension; Male; Masoprocol; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Interaction Maps; Proteomics; Pulmonary Artery; Rats, Wistar; Recovery of Function; Time Factors; Vascular Remodeling; Ventricular Function, Left; Ventricular Function, Right; Ventricular Remodeling | 2017 |
Aspirin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing the ERK/MAPK pathway.
Topics: Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Flavonoids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; MAP Kinase Signaling System; Monocrotaline; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Systole; Vascular Remodeling | 2017 |
Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
Topics: Animals; Arterial Pressure; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Focal Adhesion Kinase 1; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Integrin alphaVbeta3; Male; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Osteoprotegerin; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; RNA Interference; Severity of Illness Index; Signal Transduction; Transfection; Vascular Remodeling; Walk Test | 2017 |
Inhibition of ubiquitin proteasome function prevents monocrotaline-induced pulmonary arterial remodeling.
Topics: Animals; Bortezomib; Endosomal Sorting Complexes Required for Transport; Gene Expression Regulation, Enzymologic; Hypertension, Pulmonary; Leupeptins; Male; Monocrotaline; Nedd4 Ubiquitin Protein Ligases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; PTEN Phosphohydrolase; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Ubiquitin-Protein Ligases; Vascular Remodeling | 2017 |
Dose-dependent therapeutic effects of 2-Methoxyestradiol on Monocrotaline-Induced pulmonary hypertension and vascular remodelling.
Topics: 2-Methoxyestradiol; Animals; Dose-Response Relationship, Drug; Estradiol; Hypertension, Pulmonary; Male; Monocrotaline; Rats, Sprague-Dawley; Tubulin Modulators; Vascular Remodeling | 2010 |