monocrotaline has been researched along with Pulmonary Arterial Hypertension in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 21 (16.54) | 24.3611 |
| 2020's | 106 (83.46) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L; Li, F; Sun, X; Wan, Y; Wang, D; Wang, H | 1 |
| Araujo, AS; Baldo, G; Belló-Klein, A; Campos-Carraro, C; Constantin, RL; Fernandes-Piedras, TRG; Schenkel, PC; Teixeira, RB; Türck, P; Visioli, F; Zimmer, A | 1 |
| Eklund, M; Khoruts, A; Moutsoglou, DM; Prins, KW; Prisco, AR; Prisco, SZ; Thenappan, T; Weir, EK | 1 |
| Agulham, AP; Bertoldi, AS; Gewehr, DM; Giovanini, AF; Kubrusly, FB; Kubrusly, LF; Mattar, BA; Nagashima, S | 1 |
| Gong, X; Liu, Y; Sheng, Y; Yuan, Y; Zhao, J | 1 |
| Adekunle, AO; Adu-Amankwaah, J; Adzika, GK; Duah, M; Ma, Y; Mprah, R; Ndzie Noah, ML; Okwuma, JD; Qiao, W; Wang, C; Wowui, PI | 1 |
| Adi, D; Aierken, A; Gai, MT; Li, MY; Li, Q; Uddin, MN; Wang, J; Wang, R; Wu, Y; Yan, QZ | 1 |
| Chen, S; Ge, J; Guan, L; Jin, Q; Li, M; Li, W; Long, Y; Yang, L; Zhang, L; Zhou, D | 1 |
| Dohi, K; Hirayama, M; Ito, H; Kabwe, JC; Ko, H; Maruyama, J; Maruyama, K; Mashimo, T; Mitani, Y; Miyasaka, Y; Nishimura, Y; Ohashi, H; Okamoto, R; Oshita, H; Otsuki, S; Oya, K; Sawada, H; Tsuboya, N; Yodoya, N; Zhang, E | 1 |
| Fu, Q; He, J; Li, M; Peng, J; Tan, S; Tang, M; Tang, Y; Xie, W; Xu, X; Zhang, Q; Zhang, Y; Zheng, Z; Zhu, T | 1 |
| Chen, X; Han, X; Liu, X; Qu, C; Ran, Q; Shi, S; Sun, Y; Wan, W; Wang, X; Yang, B; Ye, T; Zhang, C; Zhao, X | 1 |
| Amazit, L; Berrebeh, N; Chaumais, MC; Chelgham, MK; Guignabert, C; Huertas, A; Humbert, M; Le Vely, B; Ottaviani, M; Phan, C; Thuillet, R; Tu, L | 1 |
| Han, H; He, M; Hu, S; Kong, H; Tan, Q; Wang, H; Wang, J; Wang, Y; Wu, X; Xie, W; Xu, J; Yang, M; Yu, M | 1 |
| Carter, LL; Clemons, B; Douthitt, A; Galkin, A; Gandjeva, A; Garcia, E; Guimond, D; Kennedy, M; Osterhout, R; Salter-Cid, L; Sitapara, R; Slee, D; Tuder, RM; Zisman, LS | 1 |
| Al-Qazazi, R; Archer, SL; Bentley, RET; Bonnet, S; Chen, KH; Dasgupta, A; Jones, O; Lima, PDA; Martin, AY; Maurice, DH; Mewburn, J; Potus, F; Prins, KW; Prisco, SZ; Provencher, S; Tian, L; Wu, D | 1 |
| Chai, L; Chen, H; Chen, Y; Li, M; Liu, J; Shen, N; Wang, J; Wang, Q; Wang, Y; Xie, X; Zhang, Q | 1 |
| Chen, X; Chen, XX; Gu, Q; He, JG; Huang, L; Li, L; Li, Y; Meng, XM; Qian, YL; Quan, RL; Wang, PH; Yang, J; Zhou, JJ | 1 |
| Bai, X; Bi, YW; Bing, WD; Jiang, DT; Qu, QX; Song, GM; Sun, WY; Tuo, L; Zhao, X | 1 |
| Boersma, E; Boomars, KA; Cai, Z; de Rijke, YB; Duncker, DJ; Geenen, LW; Guignabert, C; Kema, I; Klein, T; Koudstaal, T; Merkus, D; Reiss, IKM; Tian, S; Tran-Lundmark, K; Tu, L; van den Bosch, AE; van der Ley, C; Van Faassen, M | 1 |
| Chen, T; Li, Z; Lu, D; Su, S; Yang, Z; Zhang, D | 1 |
| Fang, C; Liu, C; Liu, K; Lv, X; Ma, Z; Wei, R | 1 |
| Feng, Z; Fu, G; Gong, Y; Jiang, D; Jin, T; Lu, J; Lv, Q; Wang, M; Ying, H | 1 |
| Aryan, L; Eghbali, M; Li, M; Medzikovic, L; Ruffenach, G | 1 |
| Kong, H; Peng, L; Wang, H; Wang, J; Wu, X; Xie, W; Xu, J; Yang, M; Yu, M; Zhou, H | 1 |
| Chen, S; Cui, H; Du, GQ; Li, Y; Shen, W; Sun, P; Wang, C; Xue, JY; Zhao, P | 1 |
| Cao, M; Li, S; Liu, H; Luan, J; Wang, J; Xue, Y; Zhai, C; Zhang, N; Zhang, Q; Zhu, Y | 1 |
| Chang, R; Cui, B; Fan, Z; Hiram, R; Huang, C; Huang, H; Liu, T; Shi, S; Su, X; Tang, Y; Wu, G; Wu, J; Xiong, F; Yan, M; Zhang, W | 1 |
| Duarte, JA; Ferreira, R; Leite-Moreira, A; Morais, F; Moreira-Gonçalves, D; Nogueira-Ferreira, R; Rocha, H; Santos, M; Silva, AF; Vilarinho, L | 1 |
| Gu, L; Liu, CJ; Liu, HM; Xie, L; Yu, L | 1 |
| Chen, SA; Chen, YC; Chen, YJ; Higa, S; Kao, YH; Lin, FJ; Lu, YY | 1 |
| Lin, S; Ma, H; Ye, P; Yu, WD; Zhang, AK; Zheng, YG | 1 |
| Carvalho, MR; Martinez, PF; Ogura, AY; Oliveira-Junior, SA | 1 |
| Bao, S; Lı, N; Lı, X; Lı, Y; Qı, L; Shı, Y; Sun, L; Wang, M; Xue, M; Yan, S; Yın, J; Zhang, J; Zhang, Q; Zhang, Y | 1 |
| Arava, SK; Arya, DS; Bhatia, J; Hote, MP; Mridha, AR; Seth, S; Shah, S; Vishwakarma, VK; Yadav, HN; Yadav, RK | 1 |
| Abid, S; Adnot, S; Beaulieu, D; Bernard, D; Born, E; Breau, M; Bulavin, DV; Delcroix, M; Derumeaux, G; Do Cruzeiro, M; Flaman, JM; Gil, J; Houssaini, A; Lefevre, M; Lipskaia, L; Marcos, E; Pierre, R; Quarck, R; Reen, V | 1 |
| Liu, Y; Nie, X; Qi, Y; Shang, J; Wu, Z; Zhu, L | 1 |
| Chen, W; Huang, T; Li, W; Liu, J; Peng, H; Song, Q; Wang, X; Xiao, Y; Xiao, Z; Zeng, Y | 1 |
| Gralinski, MR; Neves, LAA; Rosas, PC; Senese, PB | 1 |
| Chen, YL; Chiang, JY; Guo, J; Huang, CR; Lin, KC; Shao, PL; Sung, PH; Yeh, JN; Yip, HK | 1 |
| Boehm, M; Bonnet, S; Bourgeois, A; Dabral, S; de Man, F; Friedrich, A; Grobs, Y; Guenther, S; Jafari, L; Janssen, W; Khassafi, F; Kojonazarov, B; Kuenne, C; Looso, M; Maroli, G; Nayakanti, SR; Provencher, S; Pullamsetti, SS; Sarode, P; Savai, R; Schermuly, RT; Seeger, W; Tello, K; Weiss, A; Wietelmann, A; Wilhelm, J | 1 |
| Ajijola, OA; Banerjee, S; Fishbein, G; Hong, J; Magaki, S; Razee, A; Umar, S | 1 |
| Cui, L; Li, L; Ma, Q; Mou, J; Sun, G; Wang, M; Zhang, Q; Zhang, X | 1 |
| Fan, C; Li, J; Mei, F; Wang, S; Xi, R; Yang, J; Yin, Q; Yu, Y; Zhang, S; Zhang, X | 1 |
| Chen, L; Fan, F; Guan, Y; He, H; Liu, M; Qiu, L; Yang, G; Zheng, F | 1 |
| Balakin, AA; Gerzen, OP; Kuznetsov, DA; Lisin, RV; Mukhlynina, EA; Nikitina, LV; Protsenko, YL | 1 |
| Chai, L; Chen, H; Chen, Y; Feng, W; Li, D; Li, M; Liu, J; Qiu, Y; Shen, N; Shi, X; Wang, Q; Wang, Y; Xie, X; Zhang, Q | 1 |
| Araujo, ASDR; Belló-Klein, A; Campos-Carraro, C; de Lima-Seolin, BG; Teixeira, RB; Turck, P; Zimmer, A | 1 |
| Cao, N; Chen, AD; Han, Y; Liu, XX; Pan, Y; Qi, ZB; Zhang, F | 1 |
| Song, ZY; Tian, YN; Wang, WT; Wang, XT; Wang, XY; Xu, JP; Yuan, LB; Zhang, S | 1 |
| Bo, Y; Cui, Z; Tianxin, Y; Weiguo, W; Yi, Y; Zhangchi, L | 1 |
| Artigues, E; Cortijo, J; Escrivá, J; Milara, J; Montero, P; Perez-Vizcaino, F; Roger, I | 1 |
| Cai, Q; Chen, L; Li, X; Tang, L; Wang, X; Yang, Y | 1 |
| Carlström, M; Henrohn, D; Klimas, J; Kmecova, Z; Krenek, P; Malikova, E; Marusakova, M; Zsigmondova, B | 1 |
| Chen, X; Gong, S; Guo, L; Jiang, Z; Li, Y; Peng, T; Tian, Y; Wang, A | 1 |
| Lin, Y; Ma, Y; Wang, C; Zhang, H; Zhang, J | 1 |
| Guo, Y; Sun, Y; Wang, X; Zhang, N; Zhao, H | 1 |
| Affatato, R; Cantoni, S; Ceriani, S; De Giorgio, D; De Logu, F; Facchinetti, F; Fumagalli, F; Latini, R; Letizia, T; Masson, S; Milioli, M; Nassini, R; Novelli, D; Olivari, D; Ristagno, G; Russo, I; Salio, M; Staszewsky, L; Trevisani, M | 1 |
| Cai, C; Lin, W; Wu, Y; Xiang, Y; Xu, J; Zeng, C; Zhao, H; Zhu, N | 1 |
| Guo, Y; Wang, X; Wang, Y; Zhang, X; Zhao, H | 1 |
| Agostini, F; Bahr, A; Belló-Klein, A; Campos-Carraro, C; da Rosa Araujo, AS; Fraga, S; Henriques, A; Hickmann, A; Koetz, M; Lacerda, D; Ortiz, V; Salvador, I; Türck, P | 1 |
| Hu, XH; Wang, LM; Yu, RH | 1 |
| Feng, W; Li, M; Shi, W; Wang, J; Wang, Q; Yan, X; Zhai, C; Zhang, Q | 2 |
| Han, F; Liu, W; Luo, F; Shu, J | 1 |
| Cai, C; Wu, Y; Xiang, Y; Yang, L; Zeng, C; Zhao, H | 1 |
| Liu, J; Qi, XM; Sha, YH; Wang, L; Wang, W; Yang, T | 1 |
| An, N; Feng, W; Feng, Z; Guan, H; Hu, T; Hu, Y; Liu, J; Mao, Y; Mou, J; Zhang, D | 1 |
| Al-Omran, M; Bhatt, DL; Chowdhury, B; Connelly, KA; Hess, DA; Kabir, MG; Luu, AZ; Luu, VZ; Mazer, CD; Pan, Y; Quan, A; Sabongui, S; Teoh, H; Verma, S | 1 |
| Wang, Y; Wu, Q; Zhang, M; Zhong, B; Zhu, T | 1 |
| Chen, H; Gao, X; He, K; Li, C; Li, H; Li, X; Liu, C; Wei, Q; Zhang, Z | 1 |
| Lian, G; Luo, L; Wang, H; Wang, T; Xiao, G; Xie, L; Ye, C; Zhuang, W | 2 |
| Bialesova, L; Bouchard, A; Kinsella, BT; Mulvaney, EP; Reid, HM; Salvail, D | 1 |
| Gao, L; Li, SD; Liu, Y; Yang, MH; Zhang, Y | 1 |
| Chen, J; Chen, W; Dong, Q; Feng, P; Huang, W; Li, A; Li, H; Tang, M; Wang, R; Zhao, Y | 1 |
| Dianat, M; Mard, SA; Radan, M; Saryazdi, SSN; Sohrabi, F | 1 |
| Guo, Y; He, Y; Liu, X; Ouyang, F; Qiu, H; Zhang, Y | 1 |
| Arent, Z; Bielawska, J; Frączek, P; Hołda, MK; Kopeć, G; Nowakowski, M; Palka, N; Podolec, P; Sowińska, N; Szczepanek, E; Wojtysiak, D | 1 |
| Dong, S; Feng, Y; Jiang, Q; Li, J; Li, S; Li, T; Lin, W; Liu, B; Luo, H; Ou, Z; Qi, Q; Xu, Q; Yu, Z; Zeng, X; Zha, L; Zhang, M; Zhao, L | 1 |
| Antigny, F; Cohen-Kaminsky, S; Courboulin, A; Ghigna, MR; Hautefort, A; Humbert, M; Lambert, M; Le Ribeuz, H; Montani, D; Perros, F | 1 |
| Antunes, MA; Bose, RM; Braga, CL; Caruso-Neves, C; Cruz, FF; Felix, NS; Rocco, PRM; Rocha, NN; Silva, PL; Silva-Aguiar, RP; Teixeira, DE; Vieira, JB | 1 |
| Kang, JH; Kim, DW; Kim, JY; Kwon, YB; Lee, HJ; Oh, DW; Park, CW; Park, ES; Rhee, YS; Shin, DH | 1 |
| Chen, SS; Feng, YY; Ma, Y; Wang, HL | 1 |
| Cheng, TT; Chiu, MH; Fang, SY; Hsu, CH; Huang, CC; Lam, CF; Lin, MW; Roan, JN | 1 |
| Chen, XX; He, JG; Jing, XL; Li, H; Li, L; Li, Y; Meng, XM; Qian, YL; Quan, RL; Wang, PH; Zhou, JJ | 1 |
| Bertoldi, AS; Coltro, GA; Gewehr, DM; Kubrusly, FB; Kubrusly, LF; Noronha, L; Preto, PC; Salgueiro, GR; Vieira, HI | 1 |
| Gui, LX; Guo, JY; He, RL; Jiao, HX; Lin, MJ; Liu, XR; Wang, RX; Wu, ZJ; Zhang, RT | 1 |
| Nayeem, MJ; Sato, M; Yamamura, A | 1 |
| Aparicio Cordero, EA; Araujo, AS; Bahr, AC; Baldo, G; Belló-Klein, A; Campos-Carraro, C; Constantin, RL; Donatti, L; Gonzalez, E; Luz de Castro, A; Ortiz, VD; Teixeira, RB; Visioli, F; Zimmer, A | 1 |
| Huang, B; Li, L; Li, S; Luo, Y; Tang, C; Xu, S | 1 |
| Akagi, S; Amioka, N; Ejiri, K; Fukami, K; Higashimoto, Y; Ito, H; Kondo, M; Matsubara, H; Miyoshi, T; Nakamura, K; Nakayama, R; Sakaguchi, M; Suastika, LOS; Takaya, Y; Yoshida, M | 1 |
| Ge, L; Jiang, W; Li, K; Luan, Y; Qi, T; Sun, C; Wang, J; Xin, Q; Zhang, S | 1 |
| Akagi, S; Berrebeh, N; Boucly, A; Chaouat, A; Cottin, V; Cumont, A; Fadel, E; Guignabert, C; Huertas, A; Humbert, M; Jaïs, X; Jutant, EM; Le Vely, B; Mercier, O; Montani, D; Phan, C; Savale, L; Sitbon, O; Tamura, Y; Thuillet, R; Tromeur, C; Tu, L | 1 |
| Higuchi, T; Inagaki, T; Masaki, T; Nakaoka, Y; Pearson, JT; Saito, S; Schwenke, DO; Shirai, M; Tsuchimochi, H; Umetani, K | 1 |
| Cui, X; Dai, C; Feng, H; Guo, X; Jiang, F; Lu, W; Wang, J; Xu, X; Yin, Q; Zhang, J | 1 |
| He, JG; Li, H; Li, L; Li, Y; Meng, XM; Wang, PH; Zhou, JJ | 1 |
| Banerjee, S; Clark, VR; Fishbein, G; Hong, J; Park, JF; Razee, A; Saddic, L; Umar, S; Williams, T | 1 |
| Fan, Y; Gao, D; Hao, Y; Li, G; Zhang, Z | 1 |
| Borges, RS; Caetano-Souza, MM; da Silva, JKR; Dos Santos, AA; Duarte, GP; Gonzaga-Costa, K; Lahlou, S; Magalhães, PJC; Martins, CS; Roque, CR; Sousa-Brito, HL; Vasconcelos-Silva, AA | 1 |
| Chen, A; Ding, S; He, F; Kong, L; Lin, X; Ru, C; Xu, J | 1 |
| Ke, X; Liu, J; Wang, L; Yang, J; Zhang, Y | 1 |
| Li, X; Liu, H; Lu, X; Ma, W; Ren, F; Tan, X; Wang, S; Yu, L; Zhang, J | 1 |
| Belló-Klein, A; Bonetto, JP; Campos-Carraro, C; Carregal, VM; Cechinel, LR; Corssac, GB; Grings, M; Leipnitz, G; Massensini, AR; Parmeggiani, B; Siqueira, I; Zimmer, A | 1 |
| Antigny, F; Becq, F; Boet, A; Bouligand, J; Burgel, PR; Cottart, CH; Dreano, E; Ghigna, MR; Girerd, B; Hoetzenecker, K; Humbert, M; Issard, J; Lambert, M; Le Ribeuz, H; Manoury, B; Martin, C; Mercier, O; Montani, D; Nagaraj, C; Olschewski, A; Pechoux, C; Perros, F; Rucker-Martin, C; Sermet-Gaudelus, I; To, L | 1 |
| Askaripour, M; Beik, A; Jafari, E; Jafarinejad-Farsangi, S; Joukar, S; Najafipour, H; Rajabi, S; Safi, Z | 1 |
| Fan, J; Lv, Y; Ma, P; Wang, J; Xu, Q; Yan, L; Zhou, R | 1 |
| Chen, Z; Huang, T; Liu, N; Liu, Q; Wang, D; Wang, X; Xiao, Y; Xiao, Z; Xie, Y; Zeng, Y; Zuo, W | 1 |
| Dong, S; Du, H; Guo, Z; Li, P; Lu, Y; Qin, Y; Song, J; Wu, H; Zhao, X; Zhou, S; Zhu, N | 1 |
| Gao, M; Hong, W; Li, B; Li, H; Liang, C; Mo, Q; Peng, F; Peng, G; Pu, J; Ran, P; Sun, R; Wang, L; Zhao, D; Zheng, M; Zhou, Y; Zou, W | 1 |
| Blackhurst, D; Cour, M; Diaba-Nuhoho, P; Hadebe, N; Lecour, S; Marais, D | 1 |
| Ben-Batalla, I; Caruso, P; Gall, H; Ghofrani, HA; Götz, E; Grimminger, F; Herpel, S; Kojonazarov, B; Lepper, C; Loges, S; Manaud, G; Morrell, NW; Novoyatleva, T; Perros, F; Presser, N; Rai, N; Schermuly, RT; Seeger, W; Shihan, M; Upton, PD; Veeroju, S; Weissmann, N; Wharton, J; Wilkins, M | 1 |
| Iesaki, K; Matsumura, Y; Murata, Y; Nakagawa, K; Ohkita, M; Sawano, T; Tanaka, R; Tawa, M; Yamanaka, M; Yano, Y | 1 |
| Chen, H; Liu, Y; Ma, C; Wang, S; Yan, L; Zhang, H; Zhang, M; Zheng, X; Zhu, D | 1 |
| Li, P; Liu, YH; Song, P; Xu, J; Yin, YL; Zhang, MX; Zhang, WF; Zhu, TT | 1 |
| Fang, L; Huang, P; Li, QL; Xin, WX; Zheng, XW; Zhong, LK | 1 |
| Buonincontri, G; Crosby, A; Davenport, AP; Glen, RC; Kuc, RE; Maguire, JJ; Morrell, NW; Nyimanu, D; Read, C; Sawiak, SJ; Southwood, M; Williams, TL; Yang, P | 1 |
| Huang, Y; Jing, ZC; Li, J; Liu, YW; Meng, J; Pan, HZ; Wang, PH; Xiang, L; Yang, J; Zhang, H; Zhang, XL | 1 |
| Duan, YL; Ge, SL; Gong, WH; Liu, Z; Xu, JJ; Zhang, CX | 1 |
| Gao, P; Li, Y; Si, J; Yang, B; Yu, J | 1 |
| Chen, F; Chen, L; Meng, H; Wang, H; Yan, J; Yuan, L; Zhan, H; Zhao, J | 1 |
| Dong, F; Li, J; Luo, L; Ni, S; Tang, Z; Wang, P; Zhang, C; Zhang, S | 1 |
| Chang, CJ; Chang, GJ; Chen, WJ; Ho, WJ; Hsu, HC; Huang, CC; Lai, YJ; Pang, JS | 1 |
| Huang, CH; Huang, H; Li, YY; Liu, JC; Liu, ZB; Wu, QC; Xu, H; Xu, QR; Zeng, L; Zhou, XL; Zhu, RR | 1 |
| Fukumitsu, M; Suzuki, K | 1 |
| Al-Mamun, ME; Aoki, J; Doi, T; Kano, K; Kikuchi, H; Kikuchi, N; Kurosawa, R; Matsumoto, Y; Miyata, S; Nogi, M; Numano, K; Omura, J; Oshima, Y; Saigusa, D; Satoh, K; Satoh, T; Shimokawa, H; Siddique, MAH; Sunamura, S; Uruno, A; Yamamoto, M | 1 |
| Adams, V; Boekschoten, MV; Bowen, TS; van Norren, K; Vinke, P; Witkamp, RF | 1 |
| Braga, CL; Cruz, F; da Silva, JS; de Mendonça, L; Felix, NS; Rocco, PRM; Rocha, NN; Samary, CDS; Silva, PL; Vieira, JB; Zapata-Sudo, G | 1 |
1 review(s) available for monocrotaline and Pulmonary Arterial Hypertension
| Article | Year |
|---|---|
Mesenchymal stem/stromal cell therapy for pulmonary arterial hypertension: Comprehensive review of preclinical studies.
Topics: Animals; Disease Models, Animal; Hemodynamics; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Arterial Hypertension; Vascular Remodeling | 2019 |
1 trial(s) available for monocrotaline and Pulmonary Arterial Hypertension
| Article | Year |
|---|---|
Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium handling.
Topics: Animals; Arrhythmias, Cardiac; Benzhydryl Compounds; Calcium; Connexin 43; Disease Models, Animal; Fura-2; Glucose; Glucosides; Heart Failure; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Sodium; Ventricular Dysfunction, Right; Ventricular Remodeling | 2022 |
125 other study(ies) available for monocrotaline and Pulmonary Arterial Hypertension
| Article | Year |
|---|---|
Inhibition of HDAC1 alleviates monocrotaline-induced pulmonary arterial remodeling through up-regulation of miR-34a.
Topics: Animals; Benzamides; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Male; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Up-Regulation; Vascular Remodeling | 2021 |
Thioredoxin system activation is associated with the progression of experimental pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Apoptosis; Cell Survival; Collagen; Disease Progression; Electrocardiography; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Rats, Wistar; Thioredoxins | 2021 |
Intermittent Fasting Enhances Right Ventricular Function in Preclinical Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fasting; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right; Ventricular Function, Right | 2021 |
Congestive Hepatopathy Secondary to Right Ventricular Hypertrophy Related to Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Hypertrophy, Right Ventricular; Liver Diseases; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2021 |
Effects of Crocin on CCL2/CCR2 Inflammatory Pathway in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats.
Topics: Animals; Carotenoids; Chemokine CCL2; Disease Models, Animal; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Receptors, CCR2; Vascular Remodeling | 2022 |
Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Phosphatidylinositol 3-Kinases; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Vascular Endothelial Growth Factor A; Ventricular Remodeling | 2022 |
Identifying Potential Mitochondrial Proteome Signatures Associated with the Pathogenesis of Pulmonary Arterial Hypertension in the Rat Model.
Topics: Animals; Biomarkers; Disease Models, Animal; Down-Regulation; Gene Ontology; Gene Regulatory Networks; Lung; Male; MicroRNAs; Mitochondria; Monocrotaline; Protein Interaction Maps; Proteome; Proteomics; Pulmonary Arterial Hypertension; Rats; Rats, Wistar; Signal Transduction; Transcriptome; Up-Regulation | 2022 |
Efficacy of interatrial shunt devices: an opening window to acute pulmonary hypertensive crisis and chronic pulmonary arterial hypertension.
Topics: Animals; Dogs; Hemodynamics; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Arterial Hypertension | 2022 |
CRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Clustered Regularly Interspaced Short Palindromic Repeats; Fibrosis; Humans; Hypertension, Pulmonary; Lung; Mice; Monocrotaline; Point Mutation; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Tadalafil | 2022 |
Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Glucosides; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Sildenafil Citrate; Vascular Remodeling | 2022 |
Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension.
Topics: Animals; Fluvoxamine; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right; Ventricular Remodeling | 2022 |
Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Humans; Monocrotaline; Protein-Tyrosine Kinases; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2022 |
Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-κB pathways.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Glucosides; Hypertension, Pulmonary; MAP Kinase Kinase Kinases; Monocrotaline; Monoterpenes; NF-kappa B; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2022 |
Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Imatinib Mesylate; MicroRNAs; Monocrotaline; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2022 |
Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension.
Topics: Animals; Atrial Natriuretic Factor; Cytokine Receptor gp130; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fibrosis; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammasomes; Macrophage Activation; Macrophages; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Pulmonary Arterial Hypertension; Rats; Ventricular Dysfunction, Right | 2022 |
Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension.
Topics: Animals; Cell Proliferation; Endothelin-1; F-Box-WD Repeat-Containing Protein 7; Kruppel-Like Transcription Factors; MicroRNAs; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Receptor, Endothelin A; Zinc Finger Protein GLI1 | 2022 |
Transgelin exacerbates pulmonary artery smooth muscle cell dysfunction in shunt-related pulmonary arterial hypertension.
Topics: Animals; Cell Proliferation; Humans; Hypertension, Pulmonary; Microfilament Proteins; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Transforming Growth Factor beta1 | 2022 |
Prostaglandin E1 reduces apoptosis and improves the homing of mesenchymal stem cells in pulmonary arterial hypertension by regulating hypoxia-inducible factor 1 alpha.
Topics: Alprostadil; Animals; Apoptosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Vascular Endothelial Growth Factor A | 2022 |
Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα.
Topics: Animals; Endothelial Cells; Humans; Hypoxia; Interleukin-6; Kynurenic Acid; Kynurenine; Monocrotaline; Pulmonary Arterial Hypertension; Quinolinic Acid; Rats; Receptors, Interleukin-6 | 2022 |
Srolo Bzhtang reduces inflammation and vascular remodeling via suppression of the MAPK/NF-κB signaling pathway in rats with pulmonary arterial hypertension.
Topics: Animals; Cytokines; Disease Models, Animal; Hypoxia; Inflammation; Mitogen-Activated Protein Kinases; Monocrotaline; NF-kappa B; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2022 |
Silencing TUFM Inhibits Development of Monocrotaline-Induced Pulmonary Hypertension by Regulating Mitochondrial Autophagy via AMPK/mTOR Signal Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; bcl-2-Associated X Protein; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases | 2022 |
Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline.
Topics: Animals; Autophagy; Cell Proliferation; Endothelial Cells; Geranyltranstransferase; Hypertension, Pulmonary; Mevalonic Acid; Monocrotaline; Monomeric GTP-Binding Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases | 2022 |
HNRNPA2B1: RNA-Binding Protein That Orchestrates Smooth Muscle Cell Phenotype in Pulmonary Arterial Hypertension.
Topics: Animals; Cell Proliferation; Familial Primary Pulmonary Hypertension; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Hypertension, Pulmonary; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; RNA; RNA-Binding Proteins | 2022 |
Inhibition of Bruton's Tyrosine Kinase Alleviates Monocrotaline-Induced Pulmonary Arterial Hypertension by Modulating Macrophage Polarization.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Culture Media, Conditioned; Lipopolysaccharides; Macrophage Activation; Macrophages; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley | 2022 |
Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Arginine Vasopressin; Cysteine; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hepatocyte Growth Factor; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Malondialdehyde; Melatonin; Monocrotaline; NF-E2-Related Factor 2; Proto-Oncogene Proteins; Pulmonary Arterial Hypertension; Rats; RNA, Small Interfering; Ventricular Remodeling | 2022 |
Activation of Autophagy Induces Monocrotaline-Induced Pulmonary Arterial Hypertension by FOXM1-Mediated FAK Phosphorylation.
Topics: Actins; Animals; Autophagy; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Forkhead Box Protein M1; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Ki-67 Antigen; Monocrotaline; Phosphorylation; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2022 |
Exercise training counteracts the cardiac metabolic remodelling induced by experimental pulmonary arterial hypertension.
Topics: Amino Acids; Animals; Disease Models, Animal; Fatty Acids; Glucose; Glucose Transporter Type 4; Hypertension, Pulmonary; Lactate Dehydrogenases; Male; Monocrotaline; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2022 |
[Pulmonary Vascular Remodeling Characteristics of Pulmonary Arterial Hypertension Mouse Model Induced by Left Pneumonectomy and Jugular Vein Injection of Monocrotaline Pyrrole].
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Jugular Veins; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Neointima; Pneumonectomy; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling | 2022 |
Role of Endothelin-1 in Right Atrial Arrhythmogenesis in Rabbits with Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Arrhythmias, Cardiac; Connexin 43; Disease Models, Animal; Endothelin-1; Familial Primary Pulmonary Hypertension; Monocrotaline; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rabbits | 2022 |
Upregulation of miR-335-5p Contributes to Right Ventricular Remodeling via Calumenin in Pulmonary Arterial Hypertension.
Topics: Angiotensin II; Animals; Antagomirs; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Mice; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Up-Regulation; Ventricular Remodeling | 2022 |
Cardioprotective Effect of Resistance Exercise on Left Ventricular Remodeling Associated with Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Resistance Training; Vascular Remodeling; Ventricular Remodeling | 2022 |
Impact of ATP synthase/coupling factor 6 in hypoxic pulmonary arterial hypertension: An experimental rat model.
Topics: Adenosine Triphosphate; Animals; Hypertension, Pulmonary; Hypoxia; Male; Mitochondrial Proton-Translocating ATPases; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Wistar; RNA, Messenger | 2022 |
Differential effect of basal vitamin D status in monocrotaline induced pulmonary arterial hypertension in normal and vitamin D deficient rats: Possible involvement of eNOS/TGF-β/α-SMA signaling pathways.
Topics: Animals; Calcitriol; Human Umbilical Vein Endothelial Cells; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor beta; Vitamin D; Vitamin D Deficiency; Vitamins | 2023 |
Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.
Topics: Animals; Cellular Senescence; Endothelial Cells; Familial Primary Pulmonary Hypertension; Forkhead Transcription Factors; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Senotherapeutics | 2023 |
Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3β signaling pathway and alleviates pulmonary arterial hypertension in rats.
Topics: Animals; Cell Transdifferentiation; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Glycogen Synthase Kinase 3 beta; Hypertension, Pulmonary; Male; Monocrotaline; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Signal Transduction | 2023 |
Shikonin improves pulmonary vascular remodeling in monocrotaline‑induced pulmonary arterial hypertension via regulation of PKM2.
Topics: Animals; Disease Models, Animal; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyruvate Kinase; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2023 |
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Echocardiography; Heart Ventricles; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Ventricular Dysfunction, Right; Ventricular Function, Right | 2023 |
Jagged/Notch proteins promote endothelial-mesenchymal transition-mediated pulmonary arterial hypertension via upregulation of the expression of GATAs.
Topics: Animals; Familial Primary Pulmonary Hypertension; Fibronectins; Monocrotaline; Pulmonary Arterial Hypertension; Receptors, Notch; Serrate-Jagged Proteins; Up-Regulation; Vimentin | 2023 |
Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling.
Topics: Animals; beta Catenin; Catenins; Disease Models, Animal; Heart Failure; Mice; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Signal Transduction; Ventricular Function, Right; Ventricular Remodeling | 2023 |
Thoracic Spinal Cord Neuroinflammation as a Novel Therapeutic Target in Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Minocycline; Monocrotaline; Neuroinflammatory Diseases; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Spinal Cord | 2023 |
Jiedu Quyu Decoction mitigates monocrotaline-induced right-sided heart failure associated with pulmonary artery hypertension by inhibiting NLRP3 inflammasome in rats.
Topics: Animals; Biomarkers; Heart Failure; Hypertension, Pulmonary; Inflammasomes; Interleukin-18; Interleukin-1beta; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2023 |
Nobiletin attenuates monocrotaline-induced pulmonary arterial hypertension through PI3K/Akt/STAT3 pathway.
Topics: Animals; Cytokines; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2023 |
Maresin-1 protects against pulmonary arterial hypertension by improving mitochondrial homeostasis through ALXR/HSP90α axis.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Heat-Shock Proteins; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Vascular Remodeling | 2023 |
Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Heart Atria; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats | 2023 |
HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo.
Topics: Animals; Cell Proliferation; Cells, Cultured; HMGB1 Protein; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Protein Serine-Threonine Kinases; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2023 |
Copaiba oil improves pulmonary nitric oxide bioavailability in monocrotaline-treated rats.
Topics: Animals; Antioxidants; Biological Availability; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Nitric Oxide; Oils, Volatile; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Wistar | 2023 |
[Angiotensin-(1-7) improves endothelium-dependent vasodilation in rats with monocrotaline-induced pulmonary arterial hypertension].
Topics: Acetylcholine; Animals; Endothelial Cells; Endothelium; Humans; Hypertension, Pulmonary; Monocrotaline; Nitroprusside; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasodilation | 2023 |
[Panax notoginseng saponins improve monocrotaline-induced pulmonary arterial hypertension in rats by inhibiting ADAM10/Notch3 signaling pathway].
Topics: Animals; Caspase 3; Collagen; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Panax notoginseng; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Notch3; RNA, Messenger; Saline Solution; Saponins; Signal Transduction | 2023 |
Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fibrosis; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2023 |
Targeting IL-11 system as a treatment of pulmonary arterial hypertension.
Topics: Animals; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Interleukin-11; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; RNA, Small Interfering | 2023 |
Canagliflozin ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting pulmonary arterial smooth muscle cell proliferation.
Topics: Animals; Canagliflozin; Cell Proliferation; Glucose; Humans; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling | 2023 |
Effects of inorganic nitrate in a rat model of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Lung; Male; Monocrotaline; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitrites; Pulmonary Arterial Hypertension; Rats; Rats, Wistar; Superoxide Dismutase | 2020 |
eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats.
Topics: Animals; Apoptosis; Cell Proliferation; eIF-2 Kinase; Male; Monocrotaline; Muscle, Smooth; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2019 |
Protective effect of hydrogen sulfide on monocrotaline‑induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition.
Topics: Animals; Endothelial Cells; Glycine; Humans; Hydrogen Sulfide; Monocrotaline; NF-kappa B; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Signal Transduction; Snail Family Transcription Factors; Transforming Growth Factor beta1; Vascular Remodeling | 2019 |
miR-181a/b-5p ameliorates inflammatory response in monocrotaline-induced pulmonary arterial hypertension by targeting endocan.
Topics: Animals; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Inflammation; MicroRNAs; Monocrotaline; Proteoglycans; Pulmonary Arterial Hypertension; Rats; Tumor Necrosis Factor-alpha; Ventricular Remodeling | 2020 |
Monocrotaline-induced pulmonary arterial hypertension: Time-course of injury and comparative evaluation of macitentan and Y-27632, a Rho kinase inhibitor.
Topics: Amides; Animals; Endothelin Receptor Antagonists; Heart Ventricles; Hemodynamics; Hypertrophy, Right Ventricular; Male; Monocrotaline; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyridines; Pyrimidines; Rats, Wistar; rho-Associated Kinases; Sulfonamides | 2019 |
Formononetin attenuates monocrotaline‑induced pulmonary arterial hypertension via inhibiting pulmonary vascular remodeling in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Disease Models, Animal; Hemodynamics; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Isoflavones; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Phosphatidylinositol 3-Kinases; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Survival Rate; Vascular Remodeling | 2019 |
miR-181b-5p inhibits endothelial-mesenchymal transition in monocrotaline-induced pulmonary arterial hypertension by targeting endocan and TGFBR1.
Topics: Animals; Cells, Cultured; Endothelium, Vascular; Epithelial-Mesenchymal Transition; Fluorescent Antibody Technique; Male; MicroRNAs; Monocrotaline; Proteoglycans; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I | 2020 |
Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Arterial Pressure; Blueberry Plants; Disease Models, Animal; Lung; Male; Monocrotaline; Oxidation-Reduction; Plant Extracts; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Wistar | 2020 |
MiR-135a inhibitor alleviates pulmonary arterial hypertension through β-Catenin/GSK-3β signaling pathway.
Topics: Animals; beta Catenin; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Injections, Intraperitoneal; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
Topics: Animals; Apoptosis Regulatory Proteins; Immunoblotting; Male; Monocrotaline; Muscle, Smooth, Vascular; Nuclear Proteins; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ubiquitin-Protein Ligases; Vascular Remodeling; YAP-Signaling Proteins | 2020 |
Trimethoxystilbene Reduces Nuclear Factor Kappa B, Interleukin-6, and Tumor Necrosis Factor-
Topics: Animals; Cytokines; Disease Models, Animal; Female; Immunohistochemistry; Interleukin-6; Lung; Male; Monocrotaline; NF-kappa B; Pregnancy; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2019 |
Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension in rats.
Topics: Animals; Cytokines; Hemodynamics; Isoflavones; Male; MAP Kinase Signaling System; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley | 2020 |
3-Bromopyruvate alleviates the development of monocrotaline-induced rat pulmonary arterial hypertension by decreasing aerobic glycolysis, inducing apoptosis, and suppressing inflammation.
Topics: Animals; Apoptosis; Blood Pressure; Blotting, Western; Cytochromes c; Fluorescent Antibody Technique; Glycolysis; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pyruvates; Rats; Rats, Sprague-Dawley | 2020 |
Alginate Oligosaccharide Alleviates Monocrotaline-Induced Pulmonary Hypertension via Anti-Oxidant and Anti-Inflammation Pathways in Rats.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertrophy, Right Ventricular; Injections, Intraperitoneal; Male; Malondialdehyde; Monocrotaline; Pulmonary Arterial Hypertension; Random Allocation; Rats; Vascular Remodeling | 2020 |
The SGLT2 inhibitor empagliflozin reduces mortality and prevents progression in experimental pulmonary hypertension.
Topics: Animals; Benzhydryl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Heart Ventricles; Hemodynamics; Humans; Hypertrophy, Right Ventricular; Lung; Male; Models, Animal; Monocrotaline; Mortality; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Risk Assessment; Sodium-Glucose Transporter 2 Inhibitors; Vascular Remodeling | 2020 |
Aldosterone Contributed to Pulmonary Arterial Hypertension Development via Stimulating Aquaporin Expression and Pulmonary Arterial Smooth Muscle Cells Proliferation.
Topics: Aldosterone; Animals; Aquaporin 1; beta Catenin; Cell Proliferation; Disease Models, Animal; Female; Mineralocorticoid Receptor Antagonists; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Spironolactone | 2020 |
Ursolic Acid Improves Monocrotaline-Induced Right Ventricular Remodeling by Regulating Metabolism.
Topics: Animals; Apoptosis; Carnitine O-Palmitoyltransferase; Cells, Cultured; Disease Models, Animal; Energy Metabolism; Fatty Acids; Fibrosis; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; PPAR alpha; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Triterpenes; Ursolic Acid; Ventricular Function, Right; Ventricular Remodeling | 2020 |
RNA sequencing analysis of monocrotaline-induced PAH reveals dysregulated chemokine and neuroactive ligand receptor pathways.
Topics: Animals; Chemokines; Gene Expression; Inflammation; Ligands; Monocrotaline; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Sequence Analysis, RNA; Signal Transduction | 2020 |
NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.
Topics: Acetamides; Animals; Antihypertensive Agents; Disease Models, Animal; Heart Ventricles; Hemodynamics; Humans; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrazines; Rats; Rats, Inbred WKY; Receptors, Thromboxane; Sildenafil Citrate; Vascular Remodeling | 2020 |
Early Intervention of Tongxinluo () on Right Ventricular Function Assessed by Echocardiography in Rats with Pulmonary Arterial Hypertension Induced by Monocrotaline.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Echocardiography; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Function, Right | 2020 |
Dihydroartemisinin Attenuates Pulmonary Hypertension Through Inhibition of Pulmonary Vascular Remodeling in Rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antihypertensive Agents; Artemisinins; Arterial Pressure; beta Catenin; Carrier Proteins; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling; Wnt Signaling Pathway | 2020 |
Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin.
Topics: Animals; Antioxidants; Carotenoids; Disease Models, Animal; Gene Expression Regulation; Hypertrophy, Right Ventricular; Lipid Peroxidation; Male; Mitochondrial Proteins; Monocrotaline; Oxidative Stress; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2020 |
3-Bromopyruvate ameliorates pulmonary arterial hypertension by improving mitochondrial metabolism.
Topics: Animals; Disease Models, Animal; Male; Mitochondria; Monocrotaline; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyruvates; Rats; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases | 2020 |
Changes in heart morphometric parameters over the course of a monocrotaline-induced pulmonary arterial hypertension rat model.
Topics: Animals; Heart Ventricles; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2020 |
Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling.
Topics: Animals; Apoptosis; Atorvastatin; Cardiomegaly; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Endoplasmic Reticulum Stress; Hemodynamics; Inflammation; Macrophages; Male; Mitochondria; Models, Biological; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Signal Transduction | 2020 |
In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression.
Topics: Administration, Inhalation; Animals; Antagomirs; Arterial Pressure; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Male; MicroRNAs; Monocrotaline; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Potassium Channels, Tandem Pore Domain; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Wistar; Signal Transduction; Vascular Remodeling | 2020 |
Niclosamide attenuates lung vascular remodeling in experimental pulmonary arterial hypertension.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Niclosamide; Pulmonary Arterial Hypertension; Rats; Rats, Wistar; Vascular Remodeling | 2020 |
Transcriptomic analysis identifies Toll-like and Nod-like pathways and necroptosis in pulmonary arterial hypertension.
Topics: Alarmins; Animals; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation; Immunity; Inflammation; Models, Biological; Monocrotaline; Necroptosis; NLR Proteins; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptors; Transcriptome | 2020 |
Inhaled bosentan microparticles for the treatment of monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Administration, Inhalation; Animals; Bosentan; Dry Powder Inhalers; Monocrotaline; Particle Size; Pulmonary Arterial Hypertension; Rats | 2021 |
Identification of novel biomarkers involved in pulmonary arterial hypertension based on multiple-microarray analysis.
Topics: Animals; Biomarkers; Computational Biology; Datasets as Topic; Disease Models, Animal; Gene Expression Profiling; Gene Regulatory Networks; Humans; Microarray Analysis; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; RNA, Messenger | 2020 |
Transplantation of viable mitochondria improves right ventricular performance and pulmonary artery remodeling in rats with pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Vascular Remodeling; Ventricular Remodeling | 2022 |
Nestin represents a potential marker of pulmonary vascular remodeling in pulmonary arterial hypertension associated with congenital heart disease.
Topics: Adolescent; Adult; Aged; Animals; Biomarkers; Child; Child, Preschool; Endothelial Cells; Female; Heart Defects, Congenital; Humans; Lung; Male; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Nestin; Phenotype; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling; Wnt Signaling Pathway; Young Adult | 2020 |
Plexiform Lesions in an Experimental Model of Monocrotalin-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2020 |
Preventive treatment with ginsenoside Rb1 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats and involves store-operated calcium entry inhibition.
Topics: Animals; Calcium; Disease Models, Animal; Ginsenosides; Male; Monocrotaline; Panax; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction | 2020 |
The Rho kinase 2 (ROCK2)-specific inhibitor KD025 ameliorates the development of pulmonary arterial hypertension.
Topics: Animals; Cell Line; Cell Proliferation; Familial Primary Pulmonary Hypertension; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; rho-Associated Kinases; Up-Regulation; Vascular Remodeling | 2021 |
The progression of pulmonary arterial hypertension induced by monocrotaline is characterized by lung nitrosative and oxidative stress, and impaired pulmonary artery reactivity.
Topics: Animals; Arterial Pressure; Disease Models, Animal; Disease Progression; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Nitrosative Stress; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pulmonary Edema; Rats, Wistar; Receptor, Endothelin A; Time Factors; Vascular Remodeling; Vasodilation | 2021 |
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterial Pressure; Cytokines; Disease Models, Animal; Hypertrophy, Right Ventricular; Inflammation; Inflammation Mediators; Macrophages; Male; Monocrotaline; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Vascular Remodeling | 2021 |
Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Receptor for Advanced Glycation End Products | 2021 |
Mesenchymal Stromal Cell-derived Exosomes Attenuate Experimental Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Exosomes; Hypertension, Pulmonary; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Arterial Hypertension; Rats | 2021 |
Serum and pulmonary uric acid in pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Uric Acid | 2021 |
Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography.
Topics: Animals; Antihypertensive Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Monocrotaline; Predictive Value of Tests; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Synchrotrons; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX-5461 on pulmonary arterial hypertension and associated vascular remodelling.
Topics: Animals; Benzothiazoles; Cell Proliferation; Disease Models, Animal; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthyridines; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Polymerase I; Vascular Remodeling | 2021 |
CYLD mediates human pulmonary artery smooth muscle cell dysfunction in congenital heart disease-associated pulmonary arterial hypertension.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Biomarkers; Cell Movement; Cell Proliferation; Child; Child, Preschool; Deubiquitinating Enzyme CYLD; Female; Heart Defects, Congenital; Hemodynamics; Humans; Lung; Male; MAP Kinase Signaling System; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; NF-kappa B; Phenotype; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Serum; Ubiquitin Thiolesterase; Vascular Remodeling; Young Adult | 2021 |
Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Heart Failure; Heart Ventricles; Humans; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; RNA-Seq; Transcriptome; Ventricular Dysfunction, Right; Ventricular Remodeling | 2021 |
Phenotype and function of macrophage polarization in monocrotaline-induced pulmonary arterial hypertension rat model.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokines; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Macrophages; Male; Mannose Receptor; Monocrotaline; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Phenotype; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling | 2021 |
The soluble guanylate cyclase stimulator, 1-nitro-2-phenylethane, reverses monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Benzene Derivatives; Echocardiography; Endothelium, Vascular; Hemodynamics; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Wistar; Soluble Guanylyl Cyclase; Vascular Remodeling | 2021 |
Safflower injection inhibits pulmonary arterial remodeling in a monocrotaline-induced pulmonary arterial hypertension rat model.
Topics: Animals; Blood Pressure; Carthamus tinctorius; Cell Proliferation; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fibronectins; Injections; Integrins; Lung; Male; Monocrotaline; Myocardium; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Ventricular Remodeling | 2021 |
Deficiency of cold-inducible RNA-binding protein exacerbated monocrotaline-induced pulmonary artery hypertension through Caveolin1 and CAVIN1.
Topics: Animals; Animals, Genetically Modified; Caveolin 1; Cold Shock Proteins and Peptides; Endothelium, Vascular; Gene Expression Regulation; Male; Membrane Proteins; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Signal Transduction | 2021 |
Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function.
Topics: Animals; Cannabidiol; Cell Proliferation; Disease Models, Animal; Glycolysis; Hypoxia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Reactive Oxygen Species; Vascular Remodeling | 2021 |
Pulmonary arterial hypertension induces the release of circulating extracellular vesicles with oxidative content and alters redox and mitochondrial homeostasis in the brains of rats.
Topics: Animals; Brain; Disease Models, Animal; Extracellular Vesicles; Homeostasis; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Oxidation-Reduction; Oxidative Stress; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2021 |
Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension.
Topics: Animals; Cystic Fibrosis Transmembrane Conductance Regulator; Endothelial Cells; Humans; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Swine | 2021 |
Quercetin, Perillyl Alcohol, and Berberine Ameliorate Right Ventricular Disorders in Experimental Pulmonary Arterial Hypertension: Effects on miR-204, miR-27a, Fibrotic, Apoptotic, and Inflammatory Factors.
Topics: Animals; Antioxidants; Apoptosis; Berberine; Disease Models, Animal; Fibrosis; Hypertrophy, Right Ventricular; Male; MicroRNAs; Monocrotaline; Monoterpenes; Pulmonary Arterial Hypertension; Quercetin; Rats; Rats, Wistar; Ventricular Function, Right | 2021 |
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Topics: Actins; Administration, Oral; Animals; Apoptosis; Arterioles; Betaine; Cardiotonic Agents; Disease Models, Animal; Electrocardiography; Heart Failure; Heart Ventricles; Male; Monocrotaline; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Vascular Remodeling | 2021 |
Integrated analysis of m
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Down-Regulation; Fluorescent Antibody Technique; Male; Methylation; Methyltransferases; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; RNA Stability; RNA-Binding Proteins; RNA, Messenger | 2021 |
MicroRNA-663 prevents monocrotaline-induced pulmonary arterial hypertension by targeting TGF-β1/smad2/3 signaling.
Topics: Aged; Animals; Becaplermin; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Humans; Male; MicroRNAs; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Vascular Remodeling | 2021 |
Changes in the gut microbiome and metabolome in a rat model of pulmonary arterial hypertension.
Topics: Animals; Calcium; Gastrointestinal Microbiome; Male; Metabolome; Monocrotaline; Naphthalenes; Pulmonary Arterial Hypertension; Rats; Rats, Wistar; Receptors, Calcium-Sensing | 2021 |
Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension.
Topics: Animals; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Wine | 2021 |
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.
Topics: Angiogenesis Inhibitors; Animals; Bone Morphogenetic Protein Receptors, Type II; Gene Expression Regulation; Indoles; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases | 2021 |
Effects of Beet Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats.
Topics: Animals; Arterial Pressure; Beta vulgaris; Dietary Supplements; Disease Models, Animal; Fruit and Vegetable Juices; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Plant Roots; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right | 2019 |
Long noncoding RNA Hoxaas3 contributes to hypoxia-induced pulmonary artery smooth muscle cell proliferation.
Topics: Acetylation; Animals; Cell Cycle; Cell Hypoxia; Cell Line; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Histones; Homeodomain Proteins; Lysine; Male; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Processing, Post-Translational; Pulmonary Arterial Hypertension; Pulmonary Artery; RNA, Long Noncoding; Signal Transduction; Up-Regulation | 2019 |
MicroRNA-140-5p targeting tumor necrosis factor-α prevents pulmonary arterial hypertension.
Topics: Animals; Antagomirs; Base Sequence; Cell Hypoxia; Cell Movement; Cell Proliferation; Disease Models, Animal; Down-Regulation; HEK293 Cells; Humans; Male; MicroRNAs; Monocrotaline; Myocytes, Smooth Muscle; Phenotype; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation | 2019 |
Preventive Effect and Mechanism of Ethyl Acetate Extract of Sceptridium ternatum in Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Acetates; Animals; Disease Models, Animal; Female; Lung; Male; Monocrotaline; Plant Extracts; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Streptophyta | 2020 |
Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy.
Topics: Animals; Antihypertensive Agents; Autophagy; Cells, Cultured; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Nerve Tissue Proteins; Paclitaxel; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley | 2019 |
A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.
Topics: Animals; Apelin Receptors; Disease Models, Animal; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley | 2019 |
Transthoracic Pulmonary Artery Denervation for Pulmonary Arterial Hypertension.
Topics: Adolescent; Aldosterone; Animals; Child, Preschool; Cytokines; Disease Progression; Female; Fibrosis; Gene Expression Regulation; Humans; Hypertrophy; Lung; Male; Middle Aged; Monocrotaline; Neurotransmitter Agents; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Renin-Angiotensin System; Sympathectomy; Sympathetic Nervous System | 2019 |
Effect of estrogen on right ventricular remodeling of monocrotaline-induced pulmonary arterial hypertension in rats and its mechanism.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Heart Ventricles; Injections, Subcutaneous; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2019 |
Effect of MiR-21 on pulmonary arterial hypertension via the TGF-β1/Smad2 signal pathway.
Topics: Animals; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Hypertension; Hypertrophy, Right Ventricular; Interleukin-1beta; Interleukin-6; Lung; MicroRNAs; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta1 | 2020 |
Grape seed proanthocyanidin inhibits monocrotaline-induced pulmonary arterial hypertension via attenuating inflammation: in vivo and in vitro studies.
Topics: Animals; Calcium; Cell Proliferation; Cells, Cultured; Grape Seed Extract; Heart Failure; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type III; Pneumonia; Proanthocyanidins; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Vascular Remodeling | 2019 |
Adipose-derived mesenchymal stromal cells improve hemodynamic function in pulmonary arterial hypertension: identification of microRNAs implicated in modulating endothelial function.
Topics: Adipose Tissue; Animals; Apoptosis; Cell Proliferation; Cell Survival; Coculture Techniques; Disease Models, Animal; Endothelial Cells; Endothelium; Gene Ontology; Hemodynamics; Humans; Hypertrophy, Left Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Vascular Endothelial Growth Factor A | 2019 |
Cathepsin S promotes the development of pulmonary arterial hypertension.
Topics: Aged; Animals; Antihypertensive Agents; Cathepsins; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Pancreatic Elastase; PPAR gamma; Primary Cell Culture; Protease Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction | 2019 |
NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy.
Topics: Animals; Autophagy; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hemodynamics; Histone-Lysine N-Methyltransferase; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling | 2019 |
Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension.
Topics: Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Metabolism; High-Throughput Screening Assays; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Male; Metabolome; Mice; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthoquinones; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Reactive Oxygen Species; Resorcinols; Transcription Factors | 2019 |
Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Female; Fibrosis; Heart; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Skeletal; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling; Ventricular Function, Right | 2019 |
Effects of the FGF receptor-1 inhibitor, infigratinib, with or without sildenafil, in experimental pulmonary arterial hypertension.
Topics: Animals; Antihypertensive Agents; Injections, Intraperitoneal; Male; Monocrotaline; Phenylurea Compounds; Pulmonary Arterial Hypertension; Pyrimidines; Rats; Rats, Wistar; Receptor, Fibroblast Growth Factor, Type 1; Sildenafil Citrate | 2019 |