monocrotaline has been researched along with Hypertrophy, Right Ventricular in 326 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 35 (10.74) | 18.2507 |
2000's | 101 (30.98) | 29.6817 |
2010's | 150 (46.01) | 24.3611 |
2020's | 40 (12.27) | 2.80 |
Authors | Studies |
---|---|
Araujo, AS; Baldo, G; Belló-Klein, A; Campos-Carraro, C; Constantin, RL; Fernandes-Piedras, TRG; Schenkel, PC; Teixeira, RB; Türck, P; Visioli, F; Zimmer, A | 1 |
Brodaczewska, K; Kieda, C; Mackiewicz, U; Mączewski, M; Oknińska, M; Paterek, A; Szczylik, C; Torbicki, A; Zajda, K; Zambrowska, Z | 1 |
Crossman, DJ; Han, JC; Howe, K; Loiselle, DS; Ross, JM | 1 |
Ding, D; He, Y; Jiang, H; Li, X; Liu, X; Xu, Y | 1 |
Eklund, M; Khoruts, A; Moutsoglou, DM; Prins, KW; Prisco, AR; Prisco, SZ; Thenappan, T; Weir, EK | 1 |
Agulham, AP; Bertoldi, AS; Gewehr, DM; Giovanini, AF; Kubrusly, FB; Kubrusly, LF; Mattar, BA; Nagashima, S | 1 |
Goshima, Y; Goto, T; Hashimoto, T; Koga, M; Masukawa, D; Matsushita, N; Miyazaki, T; Mizuno, Y; Nakamura, F; Nakano, M; Niikura, R; Saito, M; Shimizu, T; Tamura, K; Uchimura, H; Zou, S | 1 |
Jasińska-Stroschein, M | 1 |
He, X; Hu, L; Li, L; Li, Q; Li, X; Shen, J; Tang, S; Tettey, AT; Wang, Y; Wang, Z; Wu, C; Yin, M; Zhao, C | 1 |
Al-Qazazi, R; Archer, SL; Bentley, RET; Bonnet, S; Chen, KH; Dasgupta, A; Jones, O; Lima, PDA; Martin, AY; Maurice, DH; Mewburn, J; Potus, F; Prins, KW; Prisco, SZ; Provencher, S; Tian, L; Wu, D | 1 |
Bai, X; Bi, YW; Bing, WD; Jiang, DT; Qu, QX; Song, GM; Sun, WY; Tuo, L; Zhao, X | 1 |
Chen, S; Cui, H; Du, GQ; Li, Y; Shen, W; Sun, P; Wang, C; Xue, JY; Zhao, P | 1 |
Cao, M; Li, S; Liu, H; Luan, J; Wang, J; Xue, Y; Zhai, C; Zhang, N; Zhang, Q; Zhu, Y | 1 |
Balakin, AA; Gerzen, OP; Kuznetsov, DA; Lisin, RV; Mukhlynina, EA; Nikitina, LV; Protsenko, YL | 1 |
Beserra, SS; de Lima Conceição, MR; Joviano-Santos, JV; Leal-Silva, P; Marques, LP; Roman-Campos, D; Souza, DS; Teixeira-Fonseca, JL | 1 |
Araujo, ASDR; Belló-Klein, A; Campos-Carraro, C; de Lima-Seolin, BG; Teixeira, RB; Turck, P; Zimmer, A | 1 |
Hanif, K; Jagavelu, K; Shafiq, M; Singh, N | 1 |
Affatato, R; Cantoni, S; Ceriani, S; De Giorgio, D; De Logu, F; Facchinetti, F; Fumagalli, F; Latini, R; Letizia, T; Masson, S; Milioli, M; Nassini, R; Novelli, D; Olivari, D; Ristagno, G; Russo, I; Salio, M; Staszewsky, L; Trevisani, M | 1 |
Cai, C; Lin, W; Wu, Y; Xiang, Y; Xu, J; Zeng, C; Zhao, H; Zhu, N | 1 |
Cook, T; Daniell, H; Fisher, A; Gonnella, PA; Habibi, P; Kawut, SM; Lahm, T; Mangu, V; Park, J; Shi, Y; Yakubov, B; Zeng, L | 1 |
An, N; Feng, W; Feng, Z; Guan, H; Hu, T; Hu, Y; Liu, J; Mao, Y; Mou, J; Zhang, D | 1 |
Huang, J; Iacobas, DA; Iacobas, S; Mathew, R | 1 |
Al-Omran, M; Bhatt, DL; Chowdhury, B; Connelly, KA; Hess, DA; Kabir, MG; Luu, AZ; Luu, VZ; Mazer, CD; Pan, Y; Quan, A; Sabongui, S; Teoh, H; Verma, S | 1 |
Chen, H; Gao, X; He, K; Li, C; Li, H; Li, X; Liu, C; Wei, Q; Zhang, Z | 1 |
Frede, W; Freichel, M; Gorenflo, M; Medert, R; Poth, T; Uhl, S; Vennekens, R | 1 |
Chen, X; Dong, F; Guo, Z; Peng, Y; Zhang, J; Zhang, S; Zhu, L | 1 |
Bialesova, L; Bouchard, A; Kinsella, BT; Mulvaney, EP; Reid, HM; Salvail, D | 1 |
Dianat, M; Mard, SA; Radan, M; Saryazdi, SSN; Sohrabi, F | 1 |
Jankowski, Z; Kocić, I; Sztormowska-Achranowicz, K | 1 |
Beik, A; Iranpour, M; Jafarinejad Farsangi, S; Joukar, S; Kordestani, Z; Najafipour, H; Rajabi, S | 1 |
Abe, K; Aoki, M; Aoki-Shoi, N; Bo, Z; Go, T; Hiraishi, K; Hirano, K; Inoue, R; Ishikawa, K; Kishi, H; Kobayashi, S; Koga, K; Kurahara, LH; Toru, S; Yahiro, E; Yamamura, A; Yokomise, H; Zhang, Y | 1 |
Al-Qazazi, R; Archer, SL; Eklund, M; Hartweck, L; Hsu, S; Neuber-Hess, M; Potus, F; Prins, KW; Prisco, SZ; Rose, L; Thenappan, T; Tian, L; Wu, D | 1 |
Bertoldi, AS; Coltro, GA; Gewehr, DM; Kubrusly, FB; Kubrusly, LF; Noronha, L; Preto, PC; Salgueiro, GR; Vieira, HI | 1 |
Aparicio Cordero, EA; Araujo, AS; Bahr, AC; Baldo, G; Belló-Klein, A; Campos-Carraro, C; Constantin, RL; Donatti, L; Gonzalez, E; Luz de Castro, A; Ortiz, VD; Teixeira, RB; Visioli, F; Zimmer, A | 1 |
Abdul-Salam, VB; Alvarez-Laviada, A; Dries, E; Faggian, G; Gorelik, J; Medvedev, R; Miragoli, M; Rossi, S; Sanchez-Alonso, JL; Schorn, T; Trayanova, N; Wojciak-Stothard, B | 1 |
Huang, B; Li, L; Li, S; Luo, Y; Tang, C; Xu, S | 1 |
Higuchi, T; Inagaki, T; Masaki, T; Nakaoka, Y; Pearson, JT; Saito, S; Schwenke, DO; Shirai, M; Tsuchimochi, H; Umetani, K | 1 |
Guo, J; Huo, S; Li, S; Lin, L; Luo, P; Lv, J; Peng, L; Shi, W; Wang, M; Yan, D; Zhang, C | 1 |
Borges, RS; Duarte, GP; Gonzaga-Costa, K; Lahlou, S; Magalhães, PJC; Rebouça, CDSM; Rodrigues-Silva, MJ; Vasconcelos-Silva, AA | 1 |
Cao, Y; Chen, F; Chu, C; Ding, J; Fulton, D; Hu, L; Huang, H; Li, K; Li, Y; Xu, P; Yu, Y | 1 |
Askaripour, M; Beik, A; Jafari, E; Jafarinejad-Farsangi, S; Joukar, S; Najafipour, H; Rajabi, S; Safi, Z | 1 |
Blackhurst, D; Cour, M; Diaba-Nuhoho, P; Hadebe, N; Lecour, S; Marais, D | 1 |
Choi, SJ; Hong, YM; Kim, KC; Lee, H | 1 |
Imoto, K; Okada, M; Yamawaki, H | 1 |
Chen, W; Dong, J; Gao, D; Guo, H; Lu, Y; Pan, X; Sun, Y; Xu, D; Xu, Y | 1 |
Cai, X; Huang, X; Jiang, Z; Lin, Z; Wang, H; Xie, L | 1 |
Bergmeister, H; Bonderman, D; Eilenberg, M; Kiss, A; Mascherbauer, J; Podesser, B; Schreiber, C | 1 |
Ji, W; Lin, C; Mi, L; Yu, W | 1 |
Ciambarella, BT; Fragoso, IT; Gomes, FODS; Oliveira, AC; Peixoto, CA; Ramos, IPR; Ribeiro, EL; Silva, AKSE; Silva, PME | 1 |
Li, Q; Wang, J; Wu, X; Xie, J; Xu, Y; Yu, J; Zeng, Z; Zhu, X | 1 |
Higuchi, M; Hikasa, Y; Leong, ZP; Okida, A; Yamano, Y | 1 |
Fu, N; Liang, Y; Shi, R; Wang, C; Wang, X; Wang, Y; Wei, Z; Xing, J; Yin, S; Zhu, D | 1 |
Crossman, DJ; Hickey, AJ; Loiselle, DS; Power, AS; Ward, ML | 1 |
Abdelmonsif, DA; ElAchy, SN; Hassaan, PS; Nassar, SZ | 1 |
Tan, HR; Yang, JM; Yu, JQ; Zhang, M; Zhou, R | 1 |
Bueno-Beti, C; Hadri, L; Hajjar, RJ; Sassi, Y | 1 |
Chai, L; Feng, W; Li, C; Li, M; Li, S; Liu, P; Shi, W; Wang, J; Wang, Q; Yan, X; Zhai, C; Zhang, Q; Zhu, Y | 1 |
Hikasa, Y; Leong, ZP | 1 |
Cheng, Y; He, M; Kong, H; Wang, H; Xie, W; Xu, J; Yu, M | 1 |
Du, A; Gong, J; Huang, B; Lian, G; Wang, H; Xiao, G; Xie, L; Xu, C; Zhuang, W | 1 |
Belló-Klein, A; Campos-Carraro, C; Corssac, GB; da Rosa Araujo, AS; de Lima-Seolin, BG; Dos Santos Lacerda, D; Hickmann, A; Llesuy, S; Tavares, AMV; Teixeira, RB; Turck, P | 1 |
Iesaki, K; Matsumura, Y; Murata, Y; Nakagawa, K; Ohkita, M; Sawano, T; Tanaka, R; Tawa, M; Yamanaka, M; Yano, Y | 1 |
Ding, XY; Guo, DC; Li, C; Li, YD; Lu, XZ; Shi, YP; Wang, YD; Wu, XP | 1 |
Abe, K; Hirano, K; Hirano, M; Hirooka, Y; Kuwabara, Y; Sunagawa, K; Tanaka-Ishikawa, M; Tsutsui, H | 1 |
Adthapanyawanich, K; Chootip, K; Demougeot, C; Ingkaninan, K; Temkitthawon, P; Totoson, P; Wisutthathum, S | 1 |
Chen, X; Hu, Q; Huang, L; Zhou, W | 1 |
Gao, P; Li, Y; Si, J; Yang, B; Yu, J | 1 |
Huang, CH; Huang, H; Li, YY; Liu, JC; Liu, ZB; Wu, QC; Xu, H; Xu, QR; Zeng, L; Zhou, XL; Zhu, RR | 1 |
Cai, KF; Chen, HQ | 1 |
Adams, V; Boekschoten, MV; Bowen, TS; van Norren, K; Vinke, P; Witkamp, RF | 1 |
Akers, S; Ambrosini, R; Champion, HC; Glickman, S; Haight, D; Lachant, DJ; Meoli, DF; Staicu, S; White, RJ | 1 |
Bendjelloul, F; Courtman, DW; Deng, Y; Ormiston, ML; Parker, TG; Rundle, N; Stewart, DJ; Tsoporis, JN | 1 |
Barrier, M; Biardel, S; Bisserier, M; Bonnet, P; Bonnet, S; Breuils-Bonnet, S; Carter, S; Courchesne, A; Courture, C; Deshaies, Y; Lauzon-Joset, JF; Majka, SM; Meloche, J; Paulin, R; Picard, F; Provencher, S; Racine, C; Tremblay, É | 1 |
Alencar, AK; Barreiro, EJ; Caruso-Neves, C; de Sant'Anna, CM; Ferraz, EB; Fraga, CA; Kümmerle, AE; Landgraf, SS; Maia, RC; Montagnoli, TL; Nascimento, JH; Pereira, SL; Sudo, RT; Tesch, R; Zapata-Sudo, G | 1 |
Comunoglu, C; Macit, A; Silan, C; Uzun, O; Yavuz, O; Yavuz, T; Yildirim, HA; Yuksel, H | 1 |
Li, G; Li, X; Li, Z; Liu, A; Liu, Y; Su, J; Sun, L; Xu, Y; Zhu, Y | 1 |
Eguchi, A; Hao, H; Hirota, S; Hirotani, S; Hosokawa, M; Iwasaku, T; Masuyama, T; Naito, Y; Ohyanagi, M; Okuhara, Y; Sawada, H; Tsujino, T | 1 |
Bartelds, B; Berger, RM; Borgdorff, MA; de Vroomen, M; Dickinson, MG; Steendijk, P | 1 |
Chen, GY; Hu, Y; Lin, MJ; Liu, Q; Liu, XR; Sham, JS | 1 |
Hayashi, T; Maruyama, J; Maruyama, K; Mitani, Y; Okada, A; Sawada, H; Suzuki, K; Yamada, Y; Yokochi, A; Zhang, E | 1 |
Atli, O; Bal, E; Ergun, B; Ilgin, S; Sirmagul, B | 1 |
Chen, Z; Dixon, RA; Ruan, KH; So, SP; Vanderslice, P; Willerson, JT; Zhou, L | 1 |
Aliotta, JM; Amaral, A; El-Bizri, R; Hasslinger, A; Igbinoba, Z; Klinger, JR; Pereira, M; Quesenberry, PJ; Rounds, SI; Sorokina, A | 1 |
He, B; Kang, B; Wang, Z; Xiao, J; Xie, B; Zhang, Y | 1 |
Baber, S; Kadowitz, PJ; Lasker, GF; Lasky, JA; Pankey, EA; Thammasiboon, S | 1 |
Fernandez, R; Guo, Q; Huang, JA; Yamamura, A; Yamamura, H; Yuan, JX; Zimnicka, AM | 1 |
Gu, WW; Li, HT; Liao, HX; Liu, BH; Liu, R; Qian, YX; Wu, QH; Zeng, GQ; Zhang, XF; Zhao, J | 1 |
Du, TX; Qin, N; Wei, LW | 1 |
Gupta, S; Janssen-Heininger, Y; Kim, IK; Li, L; Wei, C | 1 |
Alencar, AK; Barreiro, EJ; Caruso-Neves, C; Cunha, Vdo M; da Silva, FE; Ferraz, EB; Fraga, CA; Lima, LM; Mendes, LV; Montagnoli, TL; Nascimento, JH; Pereira, SL; Sant'anna, CM; Sudo, RT; Tesch, R; Zapata-Sudo, G | 1 |
Jasińska-Stroschein, M; Orszulak-Michalak, D; Owczarek, J; Plichta, P | 1 |
Chen, YF; Creighton, JR; Fu, J; Guo, Y; Hage, FG; Oparil, S; Xing, DD; Zhao, X | 1 |
Brinckmann, J; Herold, S; Mayer, K; Mižíková, I; Morty, RE; Nave, AH; Niess, G; Reichenberger, F; Seeger, W; Steenbock, H; Talavera, ML; Vadász, I; Veit, F; Weissmann, N | 1 |
Chen, IJ; Dai, ZK; Huang, CH; Liu, CP; Wu, BN; Wu, JR; Yeh, JL | 1 |
Goto, T; Kawakami, H; Koga, M; Mizuno, Y; Watanabe, I | 1 |
Asmis, R; Barabutis, N; Barman, SA; Black, SM; Catravas, JD; Chen, F; Dimitropoulou, C; Fulton, DJ; Giannis, A; Han, W; Jonigk, D; Keri, G; Orfi, L; Rafikov, R; Rafikova, O; Ramesh, G; Stepp, DW; Su, Y; Szabadkai, I; Szantai-Kis, C; Wang, Y | 1 |
Inoue, H; Ito, T; Kawahara, K; Maruyama, I; Noma, S; Oyama, Y; Sadamura-Takenaka, Y; Yamada, S | 1 |
Alemanni, M; Altomare, C; Barile, L; Cornaghi, L; Gobbi, M; Latini, R; Lucchetti, J; Mostacciuolo, G; Rizzetto, R; Rocchetti, M; Ronchi, C; Russo, I; Sala, L; Staszewsky, LI; Zambelli, V; Zaza, A | 1 |
Arvapalli, R; Blough, ER; Dornon, L; Hamlekhan, A; He, K; Kolli, MB; Ma, JY; Manne, NDPK; Nalabotu, SK; Nandyala, G; Para, R; Rice, KM; Shokuhfar, T; Wehner, PS | 1 |
Haga, S; Hamano, T; Hirai, T; Ishizaka, Y; Mimori, A; Tsuchiya, H | 1 |
Jasińska-Stroschein, M; Orszulak-Michalak, D; Owczarek, J; Wesołowska, A | 1 |
Chun, HJ; Comhair, SA; Erzurum, SC; Hu, X; Hwangbo, C; Ju, H; Kang, Y; Kim, J; McLean, DL; Mehrotra, D; Papangeli, I; Park, H | 1 |
Kuznetsov, D; Lookin, O; Protsenko, Y | 1 |
Gupta, S; Kim, IK; Li, L; Wei, C; Wu, L | 1 |
Chang, HJ; Kang, WJ; Kim, DH; Lee, SE; Lee, YJ; Shin, JS; Yang, PS | 1 |
Hanif, K; Kaur, G; Lingeshwar, P; Siddiqui, HH; Singh, N | 1 |
Bruce, E; Espejo, A; Francis, J; Horowitz, A; Katovich, MJ; Nair, A; Oswalt, A; Raizada, MK; Rathinasabapathy, A; Shenoy, V; Steckelings, UM; Sumners, C; Unger, T | 1 |
Jasińska-Stroschein, M; Kącikowska, J; Orszulak-Michalak, D; Owczarek, J; Surowiecka, A | 1 |
Dias-Neto, M; Eloy, C; Ferreira-Pinto, M; Gonçalves, D; Gonçalves, N; Henriques-Coelho, T; Leite-Moreira, AF; Lopes, JM; Luísa-Neves, A; Mendes, M; Pinho, S | 1 |
Qiu, M; Zhang, R; Zhang, W; Zheng, Y | 1 |
Furutani, Y; Hayama, E; Kawaguchi, N; Lan, B; Nakanishi, T | 1 |
Ding, M; Fu, E; Jin, F; Lei, J; Li, Z; Liu, S; Ma, F; Qu, Y; Xin, W; Zhang, H | 1 |
Balestra, GM; Eerbeek, O; Mik, EG; Specht, PA; van der Laarse, WJ; Zuurbier, CJ | 1 |
Huang, XN; Qin, N; Wei, LW | 1 |
Fukayama, T; Fukushima, R; Goya, S; Nakata, TM; Tanaka, R; Yoshiyuki, R | 1 |
Brown, MB; Chingombe, TJ; Cooney, SA; Fisher, AJ; Lahm, T; Novack, RA; Petrache, I; Presson, RG; Reddy, JG; Zinn, AB | 1 |
Araújo, AS; Belló-Klein, A; Colombo, R; Conzatti, A; Fernandes, TR; Siqueira, R; Tavares, AM | 1 |
Cho, MS; Choi, SJ; Hong, YM; Kim, KC; Kwon, JH; Lee, H; Lee, JC; Lee, SJ; Oh, W; Seo, ES; Wang, TJ; Yang, YS | 1 |
Antigny, F; Bonnet, S; Breuils-Bonnet, S; Johnson, I; Le Guen, M; Meloche, J; Perros, F; Potus, F; Provencher, S; Ranchoux, B; Tremblay, E; Vinck, J | 1 |
Eddahibi, S; Fadel, E; Humbert, M; Jacquin, S; Londoño-Vallejo, A; Mercier, O; Mignotte, B; Richard, S; Rincheval, V | 1 |
Blackhurst, D; Blauwet, L; Butrous, G; Davies, N; Lecour, S; Maarman, G; Sliwa, K; Thienemann, F | 1 |
Fan, F; Fan, Y; Feng, W; Ke, R; Li, F; Li, M; Li, S; Liu, L; Pan, Y; Song, Y; Wang, X; Xie, X; Zhai, C; Zhang, Y; Zhu, Y | 1 |
Cicha, K; Jasińska-Stroschein, M; Orszulak-Michalak, D; Owczarek, J | 1 |
Jiang, Y; Ye, L; Zuo, X | 1 |
Centala, A; Eghbali, M; Sharma, S; Umar, S | 1 |
Chen, C; Dong, W; Lin, X; Lv, S; Tong, G; Wang, X; Yang, D; Yang, Y | 1 |
Bhatta, RS; Hanif, K; Kaur, G; Laxman, TS; Lingeshwar, P; Mishra, A; Ramakrishna, R; Shukla, S; Siddiqui, HH; Singh, N; Singh, S | 1 |
Hara, Y; Hashizume, K; Ishiguro-Oonuma, T; Kizaki, K; Okada, M; Suemoto, M; Yoshioka, K | 1 |
Higano, S; Ishiyama, A; Kajimura, I; Minamisawa, S; Ono, Y; Yasuda, S | 1 |
Baldus, S; Behringer, A; Berghausen, EM; Blaschke, F; Caglayan, E; Er, F; Gassanov, N; Kappert, K; Odenthal, M; Rosenkranz, S; Ten Freyhaus, H; Trappiel, M; Wellnhofer, E | 1 |
Akagi, S; Egashira, K; Ito, H; Kondo, M; Matoba, T; Matsubara, H; Miura, D; Nakamura, K | 1 |
Ahmed, A; Gu, J; Gu, Y; Guo, D; Jiang, H; Zhang, Z | 1 |
Cheng, CC; Chiou, KR; Chiou, SH; Huang, WC; Ke, MW; Liu, CP; Mar, GY; Pan, HW; Shu, CW; Tseng, CJ; Wann, SR | 1 |
Gong, K; Hu, F; Mu, X; Sun, X; Wang, Y; Wu, F; Yang, D; Zhang, Z; Zheng, G | 1 |
Antigny, F; Belacel-Ouari, M; Bonnet, S; Bourgeois, A; Breuils-Bonnet, S; Dorfmüller, P; Fadel, E; Girerd, B; Hautefort, A; Humbert, M; Jourdon, P; Manoury, B; Meloche, J; Montani, D; Nadeau, V; Péchoux, C; Perros, F; Potus, F; Provencher, S; Ranchoux, B; Rucker-Martin, C; Ruffenach, G; Simonneau, G; Tremblay, E | 1 |
Black, SM; Desai, AA; Fineman, JR; Garcia, JG; Kinchen, JM; Maltepe, E; Meadows, ML; Mohney, RP; Rafikov, R; Rafikova, O; Yuan, JX | 1 |
Aliotta, JM; Baird, GL; Del Tatto, M; Dooner, MS; Goldberg, LR; Klinger, JR; Papa, E; Pereira, M; Quesenberry, PJ; Ventetuolo, CE; Wen, S | 1 |
Heo, J; Kim, IG; Kim, K; Kim, KH; Kim, Y; Lee, S; Lee, SW; Lim, J; Shin, DM | 1 |
Imoto, K; Kumatani, S; Okada, M; Yamawaki, H | 1 |
Han, X; Long, Y; Zhang, X; Zhang, Y; Zhou, Z | 1 |
Campos, DH; Carvalho, RF; Cicogna, AC; de Almeida Sabela, AK; Mariano, TB; Okoshi, K; Pacagnelli, FL; Vanderlei, LC | 1 |
Chen, Y; Duan, X; Jiang, Q; Li, M; Lu, W; Sun, D; Tang, H; Wang, J; Wang, Z; Xu, L; Yang, K; Zhang, J | 1 |
Hu, W; Huang, J; Lv, L; Xiang, Y; Ye, S; Zeng, C; Zhao, X; Zhu, N | 1 |
Adorini, L; Cellai, I; Comeglio, P; Filippi, S; Maggi, M; Maneschi, E; Morelli, A; Sarchielli, E; Vannelli, GB; Vignozzi, L | 1 |
Chlopicki, S; Fedorowicz, A; Jakubowski, A; Kopec, G; Kutryb-Zając, B; Mateuszuk, Ł; Skórka, T; Słomińska, E; Walczak, M; Zakrzewska, A; Łomnicka, M | 1 |
Lee, BH; Lee, JH; Lim, CJ; Oh, KS; Park, BK; Seo, HW; Yi, KY | 1 |
Ali, Q; Sun, Z; Varshney, R; Wu, C | 1 |
Roshchevskaya, IM; Smirnova, SL; Suslonova, OV | 1 |
Cheng, Y; Gao, H; Gong, B; Hu, J; Huang, L; Li, W; Liu, H; Qiao, C; Wang, X; Zhao, C; Zong, L | 1 |
Ahsan, F; Gupta, N; McMurtry, IF; Nozik-Grayck, E; Rashid, J; Stenmark, KR | 1 |
Cheng, G; He, L; Li, Y; Wang, X | 1 |
Cai, ZY; He, B; Li, J; Pu, J; Shen, JY; Sun, LY; Yang, CD | 1 |
Hao, Y; Niu, Y; Sun, T; Wu, F; Xu, Y; Yan, L; Yang, J; Yao, W; Yu, J; Zhou, R | 1 |
Cao, Y; Luo, H; Qin, G; Wang, E; Wang, L; Ye, Z; Yin, X; Zhang, J; Zhang, Z | 1 |
Bardou, M; Dumas, M; Goirand, F; Guerard, P; Lirussi, F; Rakotoniaina, Z; Rochette, L | 2 |
Brandão-Nogueira, A; Correia-Pinto, J; Henriques-Coelho, T; Leite-Moreira, AF; Moreira-Gonçalves, D | 1 |
Gong, QH; Huang, XN; Qin, N; Wei, LW; Wu, Q | 1 |
Amano, S; Arai, Y; Chandra, BI; Hirose, K; Ikeda, T; Kimura, Y; Komeda, M; Kushibiki, T; Marui, A; Sakaguchi, H; Tabata, Y; Yuang, H | 1 |
Hara, Y; Harada, T; Hori, Y; Kikuzuki, R; Okada, M; Yamawaki, H | 1 |
Iino, K; Ito, H; Koyama, T; Murakami, M; Ohba, T; Ono, K; Watanabe, H | 1 |
Beach, S; Budd, DC; Crosby, A; Davies, RJ; Docx, C; Duggan, N; England, K; Holmes, AM; Leblanc, C; Lebret, C; Morrell, NW; Raza, F; Schindler, F; Thomas, M; Walker, C | 1 |
Ellinghaus, P; Janssen, W; Kast, R; Klein, M; Kramer, F; Lustig, K; Milting, H; Schäfer, S | 1 |
He, JG; Tan, XY | 1 |
Gao, YH; Hao, XQ; Li, XH; Su, M; Wang, XQ; Xu, YL; Yang, DL; Yang, XJ; Zhang, HG | 1 |
Falcão-Pires, I; Gonçalves, N; Henriques-Coelho, T; Leite-Moreira, AF; Moreira-Gonçalves, D; Roncon-Albuquerque, R | 1 |
Hasegawa, Y; Inaji, H; Matsumura, Y; Nakagawa, E; Nishida, M; Ohkita, M; Tanida, I | 1 |
Gao, YH; Hao, XQ; Li, XH; Xu, YL; Yang, DL; Yang, XJ; Zhang, HG | 1 |
Chang, LT; Chua, S; Kao, YH; Ko, SF; Sheu, JJ; Sun, CK; Yen, CH; Yip, HK; Yuen, CM | 1 |
Abe, Y; Daicho, T; Marunouchi, T; Ohara, M; Takano, S; Takeo, S; Tanonaka, K; Yagi, T | 1 |
den Adel, B; Hessel, M; Schutte, C; Steendijk, P; van der Laarse, A | 1 |
Atsma, DE; Bax, WH; de Visser, YP; Laghmani, el H; Mantikou, E; Pijnappels, DA; Schalij, MJ; Schutte, CI; Steendijk, P; Umar, S; van der Laarse, A; van der Wall, EE; Wagenaar, GT | 1 |
Hara, Y; Harada, T; Kikuzuki, R; Okada, M; Yamawaki, H | 1 |
Asai, K; Ishikawa, M; Mizuno, K; Sato, N; Takano, T | 1 |
Liu, B; Liu, HM; Wang, XM; Wang, XQ; Yu, L; Zhou, TF | 1 |
Daicho, T; Daisho, Y; Kojima, S; Marunouchi, T; Takagi, N; Takano, S; Takeo, S; Tanonaka, K; Tejima, Y | 1 |
Musters, RJ; Paulus, WJ; Redout, EM; Simonides, WS; van de Kolk, CW; van der Toorn, A; van Echteld, CJ; van Hardeveld, C; Zuidwijk, MJ | 1 |
Jiang, W; Jiang, Z; Li, B; Li, Y; Wang, C; Zeng, Z | 1 |
Aoki, S; Boveda-Ruiz, D; D'Alessandro-Gabazza, CN; Gabazza, EC; Gil-Bernabe, P; Miyake, Y; Morser, J; Qin, L; Ramirez Marmol, AY; San Martin Montenegro, VT; Taguchi, O; Takagi, T; Takei, Y; Toda, M; Yano, Y | 1 |
Dackor, RT; Li, R; Ma, B; Tu, L; Wang, DW; Wang, L; Xu, X; Zeldin, DC; Zheng, C | 1 |
Cho, YK; Choi, WY; Eom, GH; Kee, HJ; Kim, HS; Kook, H; Ma, JS; Nam, KI | 1 |
de Boer, MA; Mouchaers, KT; Postmus, PE; Schalij, I; van der Laarse, WJ; van Hinsbergh, VW; van Nieuw Amerongen, GP; Vonk Noordegraaf, A | 1 |
Al-Mousily, F; Byrne, BJ; Embury, J; Gannon, KS; Germain, S; Jacques, V; Murray, J; Porvasnik, SL; Shacham, S | 1 |
Campian, ME; de Bakker, JM; de Bruin, K; Hardziyenka, M; Tan, HL; van Eck-Smit, BL; Verberne, HJ | 1 |
Archer, SL; Fang, YH; Haber, I; Thenappan, T; Urboniene, D | 1 |
Chung, MJ; Gao, S; Kim, SH; Lee, YH; Oh, YB; Park, WH; Shah, A | 1 |
Chen, JZ; Du, CQ; Hu, H; Hu, XS; Li, N; Wang, K; Yao, L; Zeng, CL; Zhang, FR | 1 |
Han, JJ; Jing, L; Qin, SC; Sun, XJ; Wang, Y; Wu, YP; Xia, ZL; Zhao, XM | 1 |
Angeli, FS; Bernstein, HS; Boyle, AJ; De Marco, T; Jahn, S; Koskenvuo, JW; Mirsky, R; Ritner, C; Sievers, RE; Yeghiazarians, Y; Yim, SM | 1 |
Benoist, D; Bernus, O; Drinkhill, M; Stones, R; White, E | 1 |
Endoh, H; Fukuda, K; Hirose, M; Miura, M; Nakano, M; Shimokawa, H; Shindoh, C; Shirato, K; Sugai, Y; Wakayama, Y | 1 |
Cornitescu, T; Dahal, BK; Ghofrani, HA; Grimminger, F; Hoffmann, J; Kaulen, C; Kosanovic, D; Kuebler, WM; Reiss, I; Savai, R; Schermuly, RT; Seeger, W; Weissmann, N | 1 |
Wang, HL; Wang, Y; Zhang, XH | 1 |
Delbeck, M; Ellinghaus, P; Kast, R; Laux, V; Nickel, KF; Perzborn, E; Schäfer, S; Schermuly, RT; Strassburger, J; von Degenfeld, G | 1 |
Brandes, RP; Cornitescu, T; Dahal, BK; Davie, N; Ghofrani, HA; Grimminger, F; Janssen, W; Kojonazarov, B; Kosanovic, D; Luitel, H; Schermuly, RT; Seeger, W; Sydykov, A; Weissmann, N | 1 |
Bache, RJ; Chen, Y; Fassett, J; Geurts, AM; Guo, H; Hu, D; Hu, X; Lu, Z; Ostertag, E; Somani, A; Tang, Q; Weir, EK; Xu, D; Xu, X; Xu, Y | 1 |
Eghbali, M; Li, J; Maltese, F; Nadadur, RD; Partownavid, P; Umar, S; van der Laarse, A | 1 |
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Anderson, ME; Chen, B; Grumbach, IM; Guo, A; Li, Y; Sanders, P; Song, LS; Wang, LC; Weiss, RM; Xie, YP; Zimmerman, K | 1 |
Baker, KM; Gupta, S; Jones, WK; Kim, IK; Kumar, R; Kumar, S; Seqqat, R; Thomas, CM; Wei, C | 1 |
Lu, Y; Luan, Y; Wang, YB; Wei, DE; Zhang, ZH | 1 |
Clozel, M; Hess, P; Rey, M | 1 |
Campen, MJ; Channell, MM; Lucas, SN; Naik, JS; Paffett, ML | 1 |
Badejo, AM; Casey, DB; Kadowitz, PJ; Lasker, GF; Murthy, SN; Nossaman, BD; Pankey, EA; Riehl, RA | 1 |
Berghausen, EM; Brandes, RP; Butrous, E; Butrous, G; Dabral, S; Dahal, BK; Ghofrani, HA; Grimminger, F; Pullamsetti, SS; Rosenkranz, S; Savai, R; Schermuly, RT; Seeger, W; Tretyn, A; Weissmann, N | 1 |
Guan, RJ; Li, JJ; Li, XL | 1 |
Dong, H; Fernandez, RA; Guo, Q; Makino, A; Pohl, NM; Smith, KA; Yamamura, A; Yamamura, H; Yuan, JX; Zeifman, A; Zimnicka, AM | 1 |
Blaudszun, G; Morel, DR | 1 |
Cui, W; Li, J; Long, C; Wang, H | 1 |
Ji, YQ; Liu, CP; Lu, WX; Zeng, Q; Zhang, WH; Zhang, YJ | 1 |
Ayon, RJ; Davis, AJ; Duan, DD; Forrest, AS; Freitas, N; Greenwood, IA; Huebner, ML; Joyce, J; Joyce, TC; Leblanc, N; Singer, CA; Valencik, ML; Wiwchar, M; Ye, L | 1 |
Ceribasi, AO; Demir, T; Kaplan, DS; Kisacik, B; Onat, AM; Orkmez, M; Pehlivan, Y; Sayarlioglu, M; Taysi, S; Turkbeyler, IH; Tutar, E | 1 |
Adamy, C; Chassagne, C; Eddahibi, S; Oliviero, P; Rappaport, L; Samuel, JL; Teiger, E | 1 |
Brindley, DN; DeAlmeida, J; Mitani, Y; Mutlu, A; Rabinovitch, M; Russell, JC | 1 |
Egashira, K; Ikeda, Y; Kataoka, C; Kitamoto, S; Nishida, K; Sueishi, K; Takeshita, A; Yamaoka, T; Yonemitsu, Y | 1 |
Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG; Qiu, D; Vaszar, LT | 1 |
Beilfuss, A; Brandt, K; Brodde, OE; Heinroth-Hoffmann, I; Leineweber, K; Pönicke, K; Wludyka, B | 1 |
Bernocchi, P; Boraso, A; Cargnoni, A; Ceconi, C; Dalla Libera, L; Ferrari, R; Parrinello, G; Vescovo, G | 1 |
Chen, MJ; Lai, YL | 1 |
Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG | 1 |
Cernacek, P; Dupuis, J; Jasmin, JF | 1 |
Brodde, OE; Hartmann, O; Hasenfuss, G; Kögler, H; Leineweber, K; Nguyen van, P; Schott, P | 1 |
Heslinga, JW; Sipkema, P; Versluis, JP; Westerhof, N | 1 |
Ahn, BH; Cho, HG; Lee, HA; Lee, WJ; Lee, YM; Park, HK; Yang, EK | 1 |
Hashimoto, K; Iwase, M; Kanazawa, H; Kato, Y; Kawata, N; Koike, Y; Nishimura, M; Nishizawa, T; Noda, A; Takagi, K; Yokoi, T; Yokota, M; Yoshimori, Y | 1 |
Bongrani, S; Cargnioni, A; Ferrari, R; Gitti, GL; Pasini, E; Pastore, F; Razzetti, R | 1 |
Abe, K; Hattori, T; Kaibuchi, K; Matsumoto, Y; Morikawa, K; Nakashima, Y; Oi, K; Shimokawa, H; Sueishi, K; Takeshit, A; Uwatoku, T | 1 |
Brunner, F; Stessel, H | 1 |
Austin, DJ; Elefteriades, JA; Goldstein, L; Keane, J; Kopf, GS; Lovoulos, C; Rocco, E; Singh, S; Tang, P; Tittle, S | 1 |
Cui, B; Dai, DZ; Zhang, TT | 1 |
Ermert, L; Ghofrani, HA; Grimminger, F; Kreisselmeier, KP; Pullamsetti, S; Samidurai, A; Schermuly, RT; Schudt, C; Seeger, W; Weissmann, N | 1 |
Eshiro, K; Matsumura, Y; Nishida, M; Okada, Y; Takaoka, M | 1 |
Baptista, MJ; Brandão-Nogueira, A; Correia-Pinto, J; Fortunato, JM; Henriques-Coelho, T; Leite-Moreira, AF; Lourenço, AP; Oliveira, SM; Roncon-Albuquerque, R; Teles, A | 1 |
Gewitz, M; Huang, J; Mathew, R; Patel, K; Sehgal, PB; Shah, M | 1 |
Bonnet, S; Dyck, JR; Haromy, A; Hashimoto, K; McMurtry, MS; Michelakis, ED; Wu, X | 1 |
Bonartsev, AP; Medvedeva, NA; Postnikov, AB; Slavutskaia, Av | 1 |
Fukushima, N; Matsuda, H; Nakamura, T; Ono, M; Sawa, Y; Suhara, H; Tanabe, T; Yokoyama, C | 1 |
Chong, AJ; Hampton, CR; Lu, J; Onoda, K; Pohlman, TH; Shimamoto, A; Shimpo, H; Spring, DJ; Takao, M; Verrier, ED; Yada, I; Yada, M | 1 |
Imaizumi, T; Kai, H; Matsui, H; Mori, T; Niiyama, H; Numaguchi, Y; Okumura, K; Sugi, Y; Tahara, N; Takayama, N; Yasukawa, H | 1 |
Brodde, OE; Dihazi, H; Hasenfuss, G; Kögler, H; Leineweber, K; Neddermeier, D; Regitz-Zagrosek, V; Schmidt, B; Schott, P; Singer, SS | 1 |
Colvin, K; Gebb, S; Imamura, M; Ivy, DD; Jones, PL; Lee, DS; McMurtry, IF; Oka, M | 1 |
Jackson, EK; Mady, HH; Melhem, MF; Salah, EM; Tofovic, SP | 1 |
Ku, DD; Sun, X | 3 |
Dai, ZK; Huang, XN; Jiang, QS; Shi, JS; Wu, Q; Yang, GZ; Zhou, QX | 2 |
Castro-Chaves, P; Henriques-Coelho, T; Leite-Moreira, AF; Rocha-Sousa, A; Soares, JB | 1 |
Fukuchi, Y; Homma, N; Morio, Y; Muramatsu, M; Sato, K; Suzuki, T; Takahashi, H; Yamamoto, A | 1 |
Bongalon, S; Dai, YP; Mutafova-Yambolieva, VN; Parks, SD; Tian, H; Yamboliev, IA | 1 |
Jin, D; Katayama, H; Kishi, K; Miyazaki, M; Muramatsu, M; Takai, S; Tamai, H | 1 |
Hadama, T; Hashimoto, Y; Inagaki, S; Kaku, T; Kimura, K; Li, Y; Miyamoto, S; Ono, K; Takebayashi, S | 1 |
den Adel, B; Hessel, MH; Schutte, CI; Steendijk, P; van der Laarse, A | 1 |
Dacic, S; Jackson, EK; Petrusevska, G; Tofovic, SP; Zhang, X | 1 |
Dupuis, J; Jasmin, JF; Lisanti, MP; Mercier, I; Tanowitz, HB | 1 |
Lamberts, RR; Stienen, GJ; Vaessen, RJ; Westerhof, N | 1 |
Hongo, M; Hoshikawa, Y; Ikeda, U; Ise, H; Ito, T; Izawa, A; Kobayashi, E; Miyashita, H; Morimoto, H; Shimada, K; Suzuki, C; Takahashi, M | 1 |
Baber, SR; Bunnell, BA; Deng, W; Hyman, AL; Kadowitz, PJ; Master, RG; Murthy, SN; Taylor, BK | 1 |
Endo, K; Hirota, M; Inai, Y; Iwasaki, T; Kajiya, F; Kajiya, M; Kiyooka, T; Mohri, S; Morimoto, T; Naruse, K; Ogasawara, Y; Ohe, T; Shimizu, J; Yada, T | 1 |
Azuma, H; Doi, S; Mizutani, S; Sasaki, A | 1 |
Fukuchi, Y; Homma, N; Morio, Y; Muramatsu, M; Nagaoka, T; Sato, K; Takahashi, H; Yamamoto, A | 1 |
Fukuda, K; Ieda, M; Kanazawa, H; Kimura, K; Kurosawa, H; Mochizuki, H; Ninomiya, S; Ogawa, S; Tsunoda, M; Yagi, T; Yamazaki, K; Yoshimi, K | 1 |
Draisma, HH; Henkens, IR; Maan, AC; Mouchaers, KT; Schalij, I; Schalij, MJ; Swenne, CA; van der Laarse, WJ; van der Wall, EE; Vliegen, HW; Vonk-Noordegraaf, A | 1 |
Blaxall, BC; Cool, CD; Galaria, II; Hall, CM; Harvey, JL; Kallop, DY; Meoli, DF; Miller, CM; Pierce, RA; Swarthout, RF; Taubman, MB; White, RJ | 1 |
Caldenhoven, E; Lamberts, RR; Lansink, M; St Cyr, JA; Stienen, GJ; Vaessen, RJ; Witte, G | 1 |
Ikeda, U; Ito, T; Kume, A; Mimuro, J; Miyashita, H; Mizukami, H; Okada, T; Ozawa, K; Sakata, Y; Shimada, K; Takahashi, M; Uchibori, R; Urabe, M | 1 |
Guan, Q; Liu, H; Liu, ZY | 1 |
Fukumoto, Y; Shimokawa, H; Tawara, S | 1 |
Atsma, D; Bax, W; Hessel, M; Schalij, M; Schutte, C; Steendijk, P; Umar, S; van der Laarse, A; van der Wall, E | 1 |
Liu, B; Liu, T; Wang, XM; Wei, L; Zhao, L; Zhou, TF | 1 |
Dony, E; Dumitrascu, R; Flockerzi, D; Ghofrani, HA; Grimminger, F; Lai, YJ; Pullamsetti, SS; Savai, R; Schermuly, RT; Schudt, C; Seeger, W; Weissmann, N | 1 |
Ikeda, M; Ito, K; Ito, KM; Kato, T; Nasu, T; Sonoda, H | 1 |
Edwards, JG; Frishman, WH; Gewitz, MH; Huang, J; Kaminski, PM; Mathew, R; Wolin, MS; Yeh, A | 1 |
Auzani, JA; Belló-Klein, A; Khaper, N; Picoral, M; Silva, LF; Souza-Rabbo, MP | 1 |
Enomoto, K; Hashimoto, M; Honda, M; Kuramochi, T; Morioka, S; Tanaka, K | 1 |
Onodera, S; Tobise, K; Yoshie, H | 1 |
Agnoletti, G; Albertini, A; Comini, L; Ferrari, R; Gaia, G; Mantero, G; Panzali, A; Pasini, E | 1 |
Arend, WP; Bridges, J; Tuder, RM; Voelkel, NF | 1 |
Enomoto, K; Hashimoto, M; Honda, M; Kuramochi, T; Mansoor, AM; Morioka, S; Tanaka, K | 1 |
Tuder, R; Voelkel, NF | 1 |
Doyle, MP; Martinez, JM; Resta, TC; Russ, RD; Walker, BR | 1 |
Arcot, SS; Gillespie, MN; Lipke, DW; Olson, JW | 1 |
Bhatti, T; Cathapermal, S; Chen, MF; Farhat, MY; Iqbal, A; Ramwell, PW | 1 |
Kikuchi, K; Mori, C; Ohie, T; Watanabe, K | 1 |
Goto, K; Miyauchi, T; Nishikibe, M; Okada, M; Sakai, S; Sakurai, T; Sugishita, Y; Yamaguchi, I; Yano, M; Yorikane, R | 1 |
Pan, LC; Segall, HJ; Wilson, DW | 1 |
Gewitz, MH; Mathew, R; Tun, H; Zeballos, GA | 1 |
Bachetti, T; Benigno, M; Ceconi, C; Comini, L; Curello, S; Ferrari, R; Gaia, G; Pasini, E | 1 |
Ashino, Y; Fujimura, S; Hoshikawa, Y; Koike, K; Nishimura, T; Noda, M; Ono, S; Tabata, T; Tanita, T; Ueda, S | 1 |
Eguchi, S; Miyamura, H; Sugawara, M; Tatebe, S; Watanabe, H | 1 |
Gewitz, MH; Gloster, ES; Mathew, R; Sundararajan, T; Thompson, CI; Zeballos, GA | 1 |
Anno, T; Honjo, H; Kamiya, K; Kodama, I; Lee, JK; Toyama, J | 1 |
Cernacek, P; Dupuis, J; Leung, TK; Prié, S; Ryan, JW | 1 |
Bernstein, M; Botney, MD; Okada, K; Patterson, GA; Tanaka, Y; Zhang, W | 1 |
Hill, NS; Klinger, JR; Pietras, L; Warburton, RR | 1 |
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Inoue, M; Iwamoto, A; Kanda, T; Kobayashi, I; Nagai, R; Sumino, H; Takahashi, T | 1 |
Horio, T; Kangawa, K; Matsuo, H; Nishikimi, T; Ohe, T; Takishita, S; Yoshihara, F; Yutani, C | 1 |
Jin, X; Liu, K; Wang, H; Xing, J; Zhang, X | 1 |
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Baybutt, RC; Molteni, A | 1 |
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Enomoto, M; Fukuta, Y; Iida, M; Ishii, K; Ishikawa, T; Iwata, H; Iwatsuki, Y; Kiyoshi, A; Nakayama, K | 1 |
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1 review(s) available for monocrotaline and Hypertrophy, Right Ventricular
Article | Year |
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A review of genetically-driven rodent models of pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Artery; Rodentia | 2022 |
325 other study(ies) available for monocrotaline and Hypertrophy, Right Ventricular
Article | Year |
---|---|
Thioredoxin system activation is associated with the progression of experimental pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Apoptosis; Cell Survival; Collagen; Disease Progression; Electrocardiography; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Rats, Wistar; Thioredoxins | 2021 |
Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Hemoglobins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Inositol Phosphates; Male; Monocrotaline; Myocardial Contraction; Rats; Rats, Wistar; Treatment Outcome; Ventricular Dysfunction, Right; Ventricular Function, Right | 2021 |
Right-sided heart failure is also associated with transverse tubule remodeling in the left ventricle.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Heart Failure; Heart Ventricles; Hypertrophy, Left Ventricular; Hypertrophy, Right Ventricular; Male; Membrane Proteins; Monocrotaline; Rats, Wistar; Ryanodine Receptor Calcium Release Channel; Sarcomeres; Ventricular Function, Left; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension.
Topics: Animals; Apoptosis; Arterial Pressure; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor CHOP; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right; X-Box Binding Protein 1 | 2021 |
Intermittent Fasting Enhances Right Ventricular Function in Preclinical Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fasting; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right; Ventricular Function, Right | 2021 |
Congestive Hepatopathy Secondary to Right Ventricular Hypertrophy Related to Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Hypertrophy, Right Ventricular; Liver Diseases; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2021 |
Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Disease Models, Animal; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Pulmonary Artery; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, G-Protein-Coupled; Receptors, Neurotransmitter; Systole; Vasoconstriction; Ventricular Dysfunction, Right; Ventricular Function, Right | 2022 |
TPN171H alleviates pulmonary hypertension via inhibiting inflammation in hypoxia and monocrotaline-induced rats.
Topics: Animals; Anti-Inflammatory Agents; Cathepsin B; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Inflammasomes; Inflammation; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Vascular Remodeling | 2022 |
Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension.
Topics: Animals; Atrial Natriuretic Factor; Cytokine Receptor gp130; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fibrosis; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammasomes; Macrophage Activation; Macrophages; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Pulmonary Arterial Hypertension; Rats; Ventricular Dysfunction, Right | 2022 |
Prostaglandin E1 reduces apoptosis and improves the homing of mesenchymal stem cells in pulmonary arterial hypertension by regulating hypoxia-inducible factor 1 alpha.
Topics: Alprostadil; Animals; Apoptosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Vascular Endothelial Growth Factor A | 2022 |
Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Arginine Vasopressin; Cysteine; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hepatocyte Growth Factor; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Malondialdehyde; Melatonin; Monocrotaline; NF-E2-Related Factor 2; Proto-Oncogene Proteins; Pulmonary Arterial Hypertension; Rats; RNA, Small Interfering; Ventricular Remodeling | 2022 |
Activation of Autophagy Induces Monocrotaline-Induced Pulmonary Arterial Hypertension by FOXM1-Mediated FAK Phosphorylation.
Topics: Actins; Animals; Autophagy; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Forkhead Box Protein M1; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Ki-67 Antigen; Monocrotaline; Phosphorylation; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2022 |
Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Heart Atria; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats | 2023 |
Exploring the involvement of TASK-1 in the control of isolated rat right atrium function from healthy animals and an experimental model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Atrial Fibrillation; Heart Atria; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Models, Theoretical; Monocrotaline; Rats; Rats, Wistar | 2023 |
Copaiba oil improves pulmonary nitric oxide bioavailability in monocrotaline-treated rats.
Topics: Animals; Antioxidants; Biological Availability; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Nitric Oxide; Oils, Volatile; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Wistar | 2023 |
Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension.
Topics: 4-Butyrolactone; Animals; Animals, Newborn; Cells, Cultured; Fatty Acid Synthase, Type I; Gene Expression Regulation, Enzymologic; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Ventricular Remodeling | 2019 |
Monocrotaline-induced pulmonary arterial hypertension: Time-course of injury and comparative evaluation of macitentan and Y-27632, a Rho kinase inhibitor.
Topics: Amides; Animals; Endothelin Receptor Antagonists; Heart Ventricles; Hemodynamics; Hypertrophy, Right Ventricular; Male; Monocrotaline; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyridines; Pyrimidines; Rats, Wistar; rho-Associated Kinases; Sulfonamides | 2019 |
Formononetin attenuates monocrotaline‑induced pulmonary arterial hypertension via inhibiting pulmonary vascular remodeling in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Disease Models, Animal; Hemodynamics; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Isoflavones; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Phosphatidylinositol 3-Kinases; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Survival Rate; Vascular Remodeling | 2019 |
Investigational new drug enabling angiotensin oral-delivery studies to attenuate pulmonary hypertension.
Topics: Animals; Drugs, Investigational; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2020 |
Alginate Oligosaccharide Alleviates Monocrotaline-Induced Pulmonary Hypertension via Anti-Oxidant and Anti-Inflammation Pathways in Rats.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertrophy, Right Ventricular; Injections, Intraperitoneal; Male; Malondialdehyde; Monocrotaline; Pulmonary Arterial Hypertension; Random Allocation; Rats; Vascular Remodeling | 2020 |
Pulmonary Hypertension Remodels the Genomic Fabrics of Major Functional Pathways.
Topics: Animals; Genomics; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction | 2020 |
The SGLT2 inhibitor empagliflozin reduces mortality and prevents progression in experimental pulmonary hypertension.
Topics: Animals; Benzhydryl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Fibrosis; Glucosides; Heart Ventricles; Hemodynamics; Humans; Hypertrophy, Right Ventricular; Lung; Male; Models, Animal; Monocrotaline; Mortality; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Risk Assessment; Sodium-Glucose Transporter 2 Inhibitors; Vascular Remodeling | 2020 |
Ursolic Acid Improves Monocrotaline-Induced Right Ventricular Remodeling by Regulating Metabolism.
Topics: Animals; Apoptosis; Carnitine O-Palmitoyltransferase; Cells, Cultured; Disease Models, Animal; Energy Metabolism; Fatty Acids; Fibrosis; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; PPAR alpha; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Triterpenes; Ursolic Acid; Ventricular Function, Right; Ventricular Remodeling | 2020 |
TRPM4 Modulates Right Ventricular Remodeling Under Pressure Load Accompanied With Decreased Expression Level.
Topics: Animals; Child; Heart Failure; Humans; Hypertrophy, Right Ventricular; Mice; Monocrotaline; Rats; Rats, Wistar; TRPM Cation Channels; Ventricular Function, Right; Ventricular Remodeling | 2020 |
Chrysin Alleviates Monocrotaline-Induced Pulmonary Hypertension in Rats Through Regulation of Intracellular Calcium Homeostasis in Pulmonary Arterial Smooth Muscle Cells.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Calcium Signaling; Disease Models, Animal; Flavonoids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats, Sprague-Dawley; TRPC Cation Channels; Vascular Remodeling; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2020 |
NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.
Topics: Acetamides; Animals; Antihypertensive Agents; Disease Models, Animal; Heart Ventricles; Hemodynamics; Humans; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrazines; Rats; Rats, Inbred WKY; Receptors, Thromboxane; Sildenafil Citrate; Vascular Remodeling | 2020 |
Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin.
Topics: Animals; Antioxidants; Carotenoids; Disease Models, Animal; Gene Expression Regulation; Hypertrophy, Right Ventricular; Lipid Peroxidation; Male; Mitochondrial Proteins; Monocrotaline; Oxidative Stress; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2020 |
Protective effect of nicotinamide and L-arginine against monocrotaline-induced pulmonary hypertension in rats: gender dependence.
Topics: Animals; Arginine; Female; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Niacinamide; Protective Agents; Pulmonary Artery; Rats; Rats, Wistar | 2020 |
Perillyle alcohol and Quercetin ameliorate monocrotaline-induced pulmonary artery hypertension in rats through PARP1-mediated miR-204 down-regulation and its downstream pathway.
Topics: Animals; Disease Models, Animal; Down-Regulation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia-Inducible Factor 1, alpha Subunit; Male; MicroRNAs; Monocrotaline; Monoterpenes; NFATC Transcription Factors; Poly (ADP-Ribose) Polymerase-1; Pulmonary Artery; Quercetin; Rats; Rats, Wistar | 2020 |
Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.
Topics: Animals; Cell Proliferation; Eicosapentaenoic Acid; Endothelial Cells; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-6; Male; Mesoderm; Monocrotaline; Myocardial Contraction; Myocytes, Smooth Muscle; Phosphorylation; Proto-Oncogene Proteins c-fyn; Pulmonary Artery; Rats, Sprague-Dawley; src-Family Kinases; STAT3 Transcription Factor; Survival Analysis; Transforming Growth Factor beta2; Vasodilation; Ventricular Remodeling | 2020 |
Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.
Topics: Acylation; Adult; Aged; AMP-Activated Protein Kinases; Animals; Cell Line; Cohort Studies; Colchicine; Diabetes Mellitus; Disease Models, Animal; Echocardiography; Gene Expression Regulation; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Hexosamines; Humans; Hypertrophy, Right Ventricular; Male; Metabolome; Middle Aged; Mitochondria; Monocrotaline; Myocytes, Cardiac; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right | 2020 |
Plexiform Lesions in an Experimental Model of Monocrotalin-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2020 |
The progression of pulmonary arterial hypertension induced by monocrotaline is characterized by lung nitrosative and oxidative stress, and impaired pulmonary artery reactivity.
Topics: Animals; Arterial Pressure; Disease Models, Animal; Disease Progression; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Nitrosative Stress; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pulmonary Edema; Rats, Wistar; Receptor, Endothelin A; Time Factors; Vascular Remodeling; Vasodilation | 2021 |
Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension.
Topics: Animals; Calcium; Calcium Signaling; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2021 |
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterial Pressure; Cytokines; Disease Models, Animal; Hypertrophy, Right Ventricular; Inflammation; Inflammation Mediators; Macrophages; Male; Monocrotaline; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Vascular Remodeling | 2021 |
Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography.
Topics: Animals; Antihypertensive Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Monocrotaline; Predictive Value of Tests; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Synchrotrons; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
S-Nitroso-L-Cysteine Ameliorated Pulmonary Hypertension in the MCT-Induced Rats through Anti-ROS and Anti-Inflammatory Pathways.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Movement; Collagen; Cysteine; Endoplasmic Reticulum Stress; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; MAP Kinase Signaling System; Matrix Metalloproteinases; Mitophagy; Monocrotaline; Muscle Contraction; Muscle, Smooth; Oxidative Stress; Phosphorylation; Rats, Sprague-Dawley; Reactive Oxygen Species; S-Nitrosothiols; STAT3 Transcription Factor; Vascular Remodeling; Wound Healing | 2021 |
Soluble guanylate cyclase stimulator, trans-4-methoxy-β-nitrostyrene, has a beneficial effect in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterioles; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Signal Transduction; Soluble Guanylyl Cyclase; Styrenes; Vascular Remodeling; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Bmi-1 alleviates adventitial fibroblast senescence by eliminating ROS in pulmonary hypertension.
Topics: Adventitia; Animals; Cell Line; Cell Proliferation; Cellular Senescence; Disease Models, Animal; Fibroblasts; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Monocrotaline; Polycomb Repressive Complex 1; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2021 |
Quercetin, Perillyl Alcohol, and Berberine Ameliorate Right Ventricular Disorders in Experimental Pulmonary Arterial Hypertension: Effects on miR-204, miR-27a, Fibrotic, Apoptotic, and Inflammatory Factors.
Topics: Animals; Antioxidants; Apoptosis; Berberine; Disease Models, Animal; Fibrosis; Hypertrophy, Right Ventricular; Male; MicroRNAs; Monocrotaline; Monoterpenes; Pulmonary Arterial Hypertension; Quercetin; Rats; Rats, Wistar; Ventricular Function, Right | 2021 |
Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension.
Topics: Animals; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Wine | 2021 |
Optimal Dose and Timing of Umbilical Stem Cells Treatment in Pulmonary Arterial Hypertensive Rats.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors | 2017 |
Expression profile of matricellular proteins in hypertrophied right ventricle of monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; CCN Intercellular Signaling Proteins; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Transcriptome | 2017 |
Valsartan attenuates pulmonary hypertension via suppression of mitogen activated protein kinase signaling and matrix metalloproteinase expression in rodents.
Topics: Animals; Blood Pressure; Cell Proliferation; Extracellular Matrix; Fibrosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; MAP Kinase Signaling System; Matrix Metalloproteinases; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Monocrotaline; Phosphorylation; Rats, Sprague-Dawley; Systole; Transforming Growth Factor beta1; Valsartan; Vascular Remodeling | 2017 |
Preventive treatment with atorvastatin ameliorates endothelial dysfunction of small pulmonary arteries in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Atorvastatin; Endothelium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Pulmonary Wedge Pressure; Random Allocation; Rats; Rats, Sprague-Dawley; Vasodilation | 2017 |
Preserved right ventricular integrity in a new telemetric rat model of severe pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Pulmonary Artery; Rats, Sprague-Dawley; Ventricular Function, Right | 2017 |
Mechanisms of N‑acetylcysteine in reducing monocrotaline‑induced pulmonary hypertension in rats: Inhibiting the expression of Nox1 in pulmonary vascular smooth muscle cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Proliferation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidase 1; Pulmonary Artery; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Vascular Remodeling | 2017 |
Diethylcarbamazine: A potential treatment drug for pulmonary hypertension?
Topics: Actins; Animals; Apoptosis; Apoptosis Regulatory Proteins; Bone Morphogenetic Protein Receptors, Type II; Collagen Type I; Diethylcarbamazine; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mice, Inbred C57BL; Monocrotaline; Pulmonary Artery; Ventricular Function, Left | 2017 |
Dihydromyricetin prevents monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Flavonols; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Vascular Remodeling | 2017 |
Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Indoles; Male; Monocrotaline; Nestin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pulmonary Artery; Pyrroles; Rats, Wistar; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting vascular remodeling in rats.
Topics: Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flavanones; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Male; MAP Kinase Signaling System; Monocrotaline; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2018 |
Calcium mishandling impairs contraction in right ventricular hypertrophy prior to overt heart failure.
Topics: Animals; Calcium; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoproterenol; Male; Monocrotaline; Myocardial Contraction; Rats; Rats, Wistar; Sarcoplasmic Reticulum | 2018 |
Cardioprotective effect of cerium oxide nanoparticles in monocrotaline rat model of pulmonary hypertension: A possible implication of endothelin-1.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cerium; Electrocardiography; Endothelin-1; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nanoparticles; Nucleosides; Organ Size; Oxidative Stress; Poisons; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Triazoles | 2018 |
Betaine Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibiting Inflammatory Response.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Betaine; Biomarkers; Chemokine CCL2; Cytokines; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Inflammation Mediators; Male; Monocrotaline; Myocardium; NF-kappa B; Pulmonary Artery; Rats | 2018 |
Pulmonary Artery Hypertension Model in Rats by Monocrotaline Administration.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Dysfunction, Right | 2018 |
Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Enzyme Activation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; NF-kappa B; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2018 |
Effects of toceranib compared with sorafenib on monocrotaline-induced pulmonary arterial hypertension and cardiopulmonary remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Autophagy; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Monocrotaline; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pulmonary Artery; Pyrroles; Rats, Wistar; Signal Transduction; Sorafenib; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Pulmonary arterial hypertension induced by a novel method: Twice-intraperitoneal injection of monocrotaline.
Topics: Animals; Cardiac Output; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Injections, Intraperitoneal; Interleukin-6; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha | 2018 |
Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Disease Models, Animal; Fabaceae; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; JNK Mitogen-Activated Protein Kinases; Male; Monocrotaline; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Plant Oils; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Signal Transduction; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Effects of Beet Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats.
Topics: Animals; Arterial Pressure; Beta vulgaris; Dietary Supplements; Disease Models, Animal; Fruit and Vegetable Juices; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Plant Roots; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right | 2019 |
17β-estradiol preserves right ventricular function in rats with pulmonary arterial hypertension: an echocardiographic and histochemical study.
Topics: Animals; Biomarkers; Disease Models, Animal; Echocardiography; Estradiol; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Natriuretic Peptide, Brain; Rats, Sprague-Dawley; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2019 |
Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imines; Male; Mice, Knockout; Monocrotaline; Pulmonary Artery; Pyridines; Rats, Sprague-Dawley; Receptor, PAR-1; Thrombin; Vascular Remodeling; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Eulophia macrobulbon extract relaxes rat isolated pulmonary artery and protects against monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Calcium; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Orchidaceae; Plant Extracts; Plant Tubers; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Thailand; Vasodilation | 2018 |
Exploration of the Notch3-HES5 signal pathway in monocrotaline-induced pulmonary hypertension using rat model.
Topics: Animals; Arterial Pressure; Arterioles; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats, Sprague-Dawley; Receptor, Notch3; Repressor Proteins; Signal Transduction; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2019 |
Effect of MiR-21 on pulmonary arterial hypertension via the TGF-β1/Smad2 signal pathway.
Topics: Animals; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Hypertension; Hypertrophy, Right Ventricular; Interleukin-1beta; Interleukin-6; Lung; MicroRNAs; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta1 | 2020 |
NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy.
Topics: Animals; Autophagy; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hemodynamics; Histone-Lysine N-Methyltransferase; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling | 2019 |
[The intervention of ginkgo biloba extract on monocrotaline-induced right ventricular hypertrophy in rats and its mechanism].
Topics: Animals; Ginkgo biloba; Hypertrophy, Right Ventricular; Male; Monocrotaline; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley | 2019 |
Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Female; Fibrosis; Heart; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Skeletal; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling; Ventricular Function, Right | 2019 |
Combination therapy improves vascular volume in female rats with pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Drug Therapy, Combination; Echocardiography; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Phenylpropionates; Pneumonectomy; Pulmonary Artery; Pyridazines; Rats; Rats, Sprague-Dawley; Tadalafil; Vascular Remodeling; Vasoconstriction; Ventricular Dysfunction, Right; X-Ray Microtomography | 2019 |
A lymphocyte-dependent mode of action for imatinib mesylate in experimental pulmonary hypertension.
Topics: Animals; Apoptosis; Benzamides; Cytokines; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Immunomodulation; Leukocyte Count; Lymphocyte Depletion; Lymphocytes; Male; Monocrotaline; Myocytes, Cardiac; Piperazines; Pyrimidines; Rats; Rats, Inbred F344; Rats, Nude | 2013 |
Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.
Topics: Adult; Aged; Animals; Apoptosis; Arterial Pressure; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Glycation End Products, Advanced; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; S100 Proteins; Signal Transduction; STAT3 Transcription Factor; Transfection; Up-Regulation | 2013 |
Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline-induced pulmonary hypertension in rats.
Topics: Adenosine A2 Receptor Agonists; Administration, Oral; Animals; Benzamides; Collagen; Endothelium, Vascular; Hemodynamics; Hydrazones; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Molecular Docking Simulation; Monocrotaline; Pulmonary Artery; Rats, Wistar; Receptors, Adenosine A2 | 2013 |
Pyrrolidine dithiocarbamate attenuates the development of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Disease Models, Animal; Endothelium, Vascular; Erythrocytes; Familial Primary Pulmonary Hypertension; Hematocrit; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates | 2013 |
ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Arterial Pressure; Cytoprotection; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Naphthalenes; Neointima; Peptide Fragments; Peptidyl-Dipeptidase A; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Resorcinols; Severity of Illness Index; Time Factors; Vasodilation | 2013 |
Impact of dietary iron restriction on the development of monocrotaline-induced pulmonary vascular remodeling and right ventricular failure in rats.
Topics: Animals; Antimicrobial Cationic Peptides; Gene Expression; Hepcidins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Iron, Dietary; Kaplan-Meier Estimate; Lung; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Transferrin; Reverse Transcriptase Polymerase Chain Reaction; Ventricular Dysfunction, Right; Ventricular Function, Right | 2013 |
Distinct loading conditions reveal various patterns of right ventricular adaptation.
Topics: Adaptation, Physiological; Animals; Arteriovenous Shunt, Surgical; Constriction; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Heart Failure; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Models, Cardiovascular; Monocrotaline; Myocardial Contraction; Physical Exertion; Pulmonary Artery; Rats; Rats, Wistar; Stroke Volume; Time Factors; Ultrasonography; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure | 2013 |
Down-regulation of TRPM8 in pulmonary arteries of pulmonary hypertensive rats.
Topics: Animals; Cations; Down-Regulation; Fura-2; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Manganese; Menthol; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; TRPM Cation Channels; Vasodilation | 2013 |
Effect of thrombomodulin on the development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Antithrombin III; Blotting, Western; Chemokine CCL2; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kaplan-Meier Estimate; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Peptide Hydrolases; Rats; Rats, Sprague-Dawley; Thrombomodulin | 2014 |
The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Catalase; Female; Glutathione; Glutathione Transferase; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Liver; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sex Characteristics; Superoxide Dismutase; Ventricular Pressure | 2013 |
Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits.
Topics: Animals; Cyclooxygenase 1; Cytochrome P-450 Enzyme System; Disease Models, Animal; Endothelial Cells; Epoprostenol; Familial Primary Pulmonary Hypertension; Genetic Therapy; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Infusions, Intravenous; Intramolecular Oxidoreductases; Male; Monocrotaline; Rats; Rats, Inbred F344; Stem Cell Transplantation; Survival Rate; Tissue Engineering; Transfection; Treatment Outcome | 2013 |
Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice.
Topics: Animals; Apoptosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Lineage; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Mice; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Phenotype; RNA, Messenger; Stem Cells; Time Factors; Transport Vesicles | 2013 |
Protection of oral hydrogen water as an antioxidant on pulmonary hypertension.
Topics: Administration, Oral; Analysis of Variance; Animals; Antioxidants; Atrial Natriuretic Factor; Blood Pressure; Blotting, Western; Hydrogen; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intercellular Adhesion Molecule-1; Models, Animal; Monocrotaline; Rats | 2013 |
Imatinib attenuates monocrotaline pulmonary hypertension and has potent vasodilator activity in pulmonary and systemic vascular beds in the rat.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Benzamides; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Muscle, Smooth, Vascular; Phosphodiesterase 4 Inhibitors; Piperazines; Potassium Channel Blockers; Protein Kinase Inhibitors; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Vasoconstriction; Vasodilation; Vasodilator Agents | 2013 |
Inhibition of the Ca(2+)-sensing receptor rescues pulmonary hypertension in rats and mice.
Topics: Animals; Blotting, Western; Calcium; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Myocardium; Poisons; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Calcium-Sensing | 2014 |
Single intraperitoneal injection of monocrotaline as a novel large animal model of chronic pulmonary hypertension in Tibet minipigs.
Topics: Animals; Disease Models, Animal; Echocardiography; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Artery; Swine; Swine, Miniature | 2013 |
[Inhibitory effect of nitric oxide-induced total ginsenosides on right ventricular hypertrophy in rats].
Topics: Animals; Ginsenosides; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Random Allocation; Rats; Rats, Sprague-Dawley | 2013 |
Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II; Cell Nucleus; Cytokines; Endothelial Cells; Gene Expression; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; I-kappa B Proteins; Lung; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Monocrotaline; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Receptor, Notch3; Receptors, Notch; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factor RelA | 2014 |
N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity.
Topics: Adenosine A2 Receptor Agonists; Animals; Benzamides; Exercise Tolerance; Hydrazones; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats, Wistar; Receptor, Adenosine A2A; Ultrasonography; Vasodilation | 2014 |
Concurrent rho-kinase and tyrosine kinase platelet-derived growth factor inhibition in experimental pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Becaplermin; Benzamides; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrimidines; Rats; Rats, Wistar; Receptors, Platelet-Derived Growth Factor; rho-Associated Kinases; Ventricular Pressure | 2014 |
Targeted delivery of pulmonary arterial endothelial cells overexpressing interleukin-8 receptors attenuates monocrotaline-induced pulmonary vascular remodeling.
Topics: Adenoviridae; Animals; Arterial Pressure; Cells, Cultured; Chemokine CCL2; Chemokines, CXC; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Female; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages; Monocrotaline; Neutrophil Infiltration; Neutrophils; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovariectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-8; Transduction, Genetic; Up-Regulation; Ventricular Function, Right; Ventricular Remodeling | 2014 |
Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension.
Topics: Adult; Aged, 80 and over; Animals; Antihypertensive Agents; Case-Control Studies; Cell Hypoxia; Cells, Cultured; Collagen; Disease Models, Animal; Elastin; Enzyme Inhibitors; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Isoenzymes; Male; Mice; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein-Lysine 6-Oxidase; Pulmonary Artery; Rats; RNA, Messenger; Ventricular Dysfunction, Right; Young Adult | 2014 |
Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model.
Topics: Animals; Blood Pressure; Body Weight; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelin-1; Guanylate Cyclase; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Nitric Oxide Synthase Type III; Piperazines; Piperidines; Pulmonary Artery; Purines; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfonamides; Vasoconstriction; Xanthines | 2014 |
Role of VPAC2 receptor in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Ligands; Male; Monocrotaline; Pituitary Adenylate Cyclase-Activating Polypeptide; Poisons; Rats; Rats, Sprague-Dawley; Receptors, Vasoactive Intestinal Peptide, Type II; Receptors, Vasoactive Intestinal Polypeptide, Type I; Vasoactive Intestinal Peptide | 2014 |
NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling.
Topics: Adventitia; Animals; Antihypertensive Agents; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fibroblasts; HEK293 Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection; Up-Regulation | 2014 |
HMGB1 promotes the development of pulmonary arterial hypertension in rats.
Topics: Animals; Bronchoalveolar Lavage Fluid; Chemokine CCL2; Disease Models, Animal; DNA-Binding Proteins; Endothelin-1; Hemodynamics; HMGB1 Protein; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Interleukin-1beta; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vascular Resistance; Ventricular Dysfunction, Right | 2014 |
Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension.
Topics: Acetanilides; Animals; Calcium Signaling; Collagen; Disease Models, Animal; Fibrosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Membrane Potentials; Monocrotaline; Myocytes, Cardiac; Myosin Heavy Chains; Piperazines; Pulmonary Artery; Ranolazine; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Sodium Channels; Time Factors; Vascular Remodeling; Vascular Resistance; Ventricular Function, Right; Ventricular Remodeling | 2014 |
Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Cerium; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nanoparticles; Rats; Rats, Sprague-Dawley | 2014 |
A novel ACE2 activator reduces monocrotaline-induced pulmonary hypertension by suppressing the JAK/STAT and TGF-β cascades with restored caveolin-1 expression.
Topics: Angiotensin-Converting Enzyme 2; Animals; Caveolin 1; Drug Evaluation, Preclinical; Enzyme Activation; Feedback, Physiological; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Janus Kinases; Male; Monocrotaline; Oxazoles; Peptidyl-Dipeptidase A; Pyrimidines; Rats, Sprague-Dawley; STAT Transcription Factors; Transforming Growth Factor beta | 2015 |
Rosuvastatin, sildenafil and their combination in monocrotaline-induced pulmonary hypertension in rat.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Biomarkers; Cholesterol, HDL; Disease Models, Animal; Drug Therapy, Combination; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Natriuretic Peptide, Brain; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Purines; Pyrimidines; Rats, Wistar; Rosuvastatin Calcium; Sildenafil Citrate; Sulfonamides; Time Factors; Vascular Endothelial Growth Factor A; Vascular Remodeling; Vasodilator Agents; Ventricular Function, Right; Ventricular Pressure | 2014 |
Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.
Topics: Animals; Apelin; Arterioles; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells; Fibroblast Growth Factor 2; Hemodynamics; Histone Deacetylase Inhibitors; Hydroxamic Acids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Intercellular Signaling Peptides and Proteins; Male; MEF2 Transcription Factors; MicroRNAs; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Transcription, Genetic | 2015 |
Sex differences in stretch-dependent effects on tension and Ca(2+) transient of rat trabeculae in monocrotaline pulmonary hypertension.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Endothelium, Vascular; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Pulmonary Veins; Rats; Rats, Wistar; Sex Characteristics | 2015 |
Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
Topics: Animals; Cells, Cultured; Collagen Type III; Connective Tissue Growth Factor; Disease Models, Animal; Endothelial Cells; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Intraperitoneal; Lung; Male; Mice; Monocrotaline; Receptor, Notch3; Receptors, Notch; Signal Transduction; Thymosin | 2014 |
Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Glycyrrhizic Acid; HMGB1 Protein; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle, Smooth, Vascular; Pneumonia; Pulmonary Artery; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right | 2014 |
Poly (ADP-ribose) polymerase-1: an emerging target in right ventricle dysfunction associated with pulmonary hypertension.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Isoquinolines; Male; Mitochondria; Mitochondrial Membranes; Monocrotaline; NAD; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-2; Ventricular Dysfunction, Right | 2015 |
Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imidazoles; Lung; Male; Monocrotaline; Myocardium; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pulmonary Fibrosis; Pyridines; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Signal Transduction; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2015 |
HMG-COA reductase inhibitors: An opportunity for the improvement of imatinib safety. An experimental study in rat pulmonary hypertension.
Topics: Animals; Drug Synergism; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Organ Size; Rats; Rats, Wistar; Rosuvastatin Calcium; Simvastatin | 2015 |
Pathophysiology of infantile pulmonary arterial hypertension induced by monocrotaline.
Topics: Animals; Animals, Newborn; Collagen Type I; Collagen Type III; Disease Models, Animal; Endothelin-1; Female; Heart; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Myocytes, Cardiac; Natriuretic Peptide, Brain; Pyrrolizidine Alkaloids; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Transcription Factors | 2015 |
[Glycoltic metabolism gene changes in left and right ventricles in experimental rat pulmonary arterial hypertension model].
Topics: Animals; Gene Expression; Heart Ventricles; Hemodynamics; Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Rats | 2014 |
Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hemodynamics; Histone Deacetylase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Valproic Acid | 2015 |
Calorie Restriction Attenuates Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
Topics: Acetylation; Adenoviridae; Animals; Arterial Pressure; Caloric Restriction; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Genetic Vectors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Time Factors; Transduction, Genetic; Vascular Remodeling; Vasodilation; Vasodilator Agents | 2015 |
Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure?
Topics: Administration, Inhalation; Animals; Arterial Pressure; Cardiotonic Agents; Disease Models, Animal; Disease Progression; Dobutamine; Energy Metabolism; Heart Failure; Hexokinase; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; L-Lactate Dehydrogenase; Male; Mitochondria, Heart; Monocrotaline; Oxygen; Oxygen Consumption; Protoporphyrins; Pulmonary Artery; Rats, Wistar; Ventricular Dysfunction, Right; Ventricular Function, Right | 2015 |
[Total ginsenosides fought against right ventricular hypertrophy through inhibiting calcineurin signal pathway].
Topics: Animals; Atrial Natriuretic Factor; Calcineurin; Calcineurin Inhibitors; Ginsenosides; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 2015 |
Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats With Monocrotaline-induced Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nicorandil; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 5 Inhibitors; Pyridazines; Rats, Wistar; Recovery of Function; Severity of Illness Index; Sildenafil Citrate; Vasodilator Agents; Ventricular Dysfunction, Right; Ventricular Function, Right | 2015 |
Novel assessment of haemodynamic kinetics with acute exercise in a rat model of pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Blood Pressure Monitoring, Ambulatory; Disease Models, Animal; Enzyme Activation; Exercise Therapy; Glycolysis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kinetics; Male; Monocrotaline; Muscle, Skeletal; Myocardium; Nitric Oxide Synthase Type III; Predictive Value of Tests; Pulmonary Artery; Rats, Sprague-Dawley; Telemetry; Ventricular Function, Right; Ventricular Pressure | 2015 |
Aerobic Exercise Promotes a Decrease in Right Ventricle Apoptotic Proteins in Experimental Cor Pulmonale.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Disease Models, Animal; Echocardiography; Hemodynamics; Hydrogen Peroxide; Hypertrophy, Right Ventricular; Male; Monocrotaline; Physical Conditioning, Animal; Pulmonary Artery; Pulmonary Heart Disease; Rats, Wistar; Vascular Resistance; Ventricular Function, Right; Ventricular Remodeling | 2015 |
The Effect of Umbilical Cord Blood Derived Mesenchymal Stem Cells in Monocrotaline-induced Pulmonary Artery Hypertension Rats.
Topics: Animals; Cytokines; Disease Models, Animal; Endothelin-1; Fetal Blood; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Matrix Metalloproteinase 2; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A | 2015 |
miR-223 reverses experimental pulmonary arterial hypertension.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; DNA Damage; Down-Regulation; Female; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; MicroRNAs; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2015 |
Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats.
Topics: Animals; Apoptosis; Benzothiazoles; Cell Proliferation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Wistar; Toluene; Tumor Suppressor Protein p53 | 2015 |
Melatonin as a preventive and curative therapy against pulmonary hypertension.
Topics: Animals; Antioxidants; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Melatonin; Monocrotaline; Rats; Rats, Long-Evans; Ventricular Dysfunction, Right | 2015 |
Inhibition of Notch3 prevents monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Notch3; Receptors, Notch; Signal Transduction | 2015 |
Influence of imatinib at a low dose and sildenafil on pulmonary hypertension in rats.
Topics: Animals; Blood Pressure; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Protein Kinase Inhibitors; Rats; Rats, Wistar; Sildenafil Citrate; Vasodilator Agents | 2015 |
Farnesoid-X-receptor expression in monocrotaline-induced pulmonary arterial hypertension and right heart failure.
Topics: Animals; Disease Models, Animal; Gene Expression; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Vascular Remodeling; Ventricular Remodeling | 2015 |
Role of miR206 in genistein-induced rescue of pulmonary hypertension in monocrotaline model.
Topics: Angiogenesis Inducing Agents; Animals; Capillaries; Electrocardiography; Gene Knockdown Techniques; Genistein; Heart Function Tests; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; MicroRNAs; Monocrotaline; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Vascular Endothelial Growth Factor A | 2015 |
Tetrandrine prevents monocrotaline-induced pulmonary arterial hypertension in rats through regulation of the protein expression of inducible nitric oxide synthase and cyclic guanosine monophosphate-dependent protein kinase type 1.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Benzylisoquinolines; Catalase; Cell Proliferation; Cyclic GMP-Dependent Protein Kinase Type I; Disease Models, Animal; Glutathione; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Oxidative Stress; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase; Time Factors; Vascular Remodeling; Ventricular Remodeling | 2016 |
A study on the involvement of GABA-transaminase in MCT induced pulmonary hypertension.
Topics: 4-Aminobutyrate Transaminase; Animals; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Norepinephrine; Oxidative Stress; Oxygen; Pneumonia; Rats; Rats, Sprague-Dawley; Survival Analysis; Vigabatrin | 2016 |
Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats.
Topics: Animals; Disease Models, Animal; Gene Expression; Glucuronidase; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Rats; Rats, Wistar | 2016 |
Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2015 |
Pioglitazone alleviates cardiac and vascular remodelling and improves survival in monocrotaline induced pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages, Alveolar; Male; Monocrotaline; Myocytes, Cardiac; Natriuretic Peptide, Brain; Osteopontin; Pioglitazone; PPAR gamma; Pulmonary Artery; Rats, Sprague-Dawley; Thiazolidinediones; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2016 |
Intratracheal Administration of Prostacyclin Analogue-incorporated Nanoparticles Ameliorates the Development of Monocrotaline and Sugen-Hypoxia-induced Pulmonary Arterial Hypertension.
Topics: Adolescent; Adult; Animals; Cell Hypoxia; Cell Proliferation; Child; Disease Models, Animal; Drug Delivery Systems; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Smooth Muscle; Nanoparticles; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors; Young Adult | 2016 |
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Topics: Acetophenones; Acetylcysteine; Animals; Apoptosis; Calcium; Calcium Channels, L-Type; Cell Proliferation; Gene Expression Regulation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Metalloporphyrins; Monocrotaline; Myocytes, Smooth Muscle; Organ Culture Techniques; Pentose Phosphate Pathway; Phosphorylation; Primary Cell Culture; Pulmonary Artery; Pyruvate Kinase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serine | 2016 |
Therapeutic Benefits of Induced Pluripotent Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Adult; Animals; Cells, Cultured; Culture Media, Conditioned; Cytokines; Disease Models, Animal; Down-Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Interferon-gamma; Interleukins; Lung; Macrophages; Male; Monocrotaline; NF-kappa B; Phosphorylation; Pluripotent Stem Cells; Pulmonary Artery; Rats | 2016 |
Protective effects of drag-reducing polymers in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-1beta; Interleukin-6; Male; Monocrotaline; Polyethylene Glycols; Polymers; Pulmonary Artery; Rats; Rats, Wistar; Surface-Active Agents | 2016 |
Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.
Topics: Adventitia; Animals; Bone Morphogenetic Protein Receptors, Type II; Cell Division; Endothelium, Vascular; Fibroblasts; Genetic Predisposition to Disease; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Male; Membrane Potentials; Monocrotaline; Mutation; Myocytes, Smooth Muscle; Nerve Tissue Proteins; ortho-Aminobenzoates; Patch-Clamp Techniques; Potassium Channels, Tandem Pore Domain; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfonamides; Vascular Resistance | 2016 |
Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.
Topics: Animals; Blood Pressure; Carnitine; Disease Models, Animal; Disease Progression; Glutathione; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Metabolic Networks and Pathways; Metabolome; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors | 2016 |
Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice.
Topics: Animals; Case-Control Studies; Cell-Derived Microparticles; Cells, Cultured; Disease Models, Animal; Exosomes; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Pulmonary Artery; Vascular Remodeling | 2016 |
Priming with ceramide-1 phosphate promotes the therapeutic effect of mesenchymal stem/stromal cells on pulmonary artery hypertension.
Topics: Animals; Anti-Inflammatory Agents; Cell Movement; Cell Proliferation; Ceramides; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; MAP Kinase Signaling System; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Inbred Lew; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells | 2016 |
Endostatin is protective against monocrotaline-induced right heart disease through the inhibition of T-type Ca(2+) channel.
Topics: Animals; Blood Pressure; Calcium Channels, T-Type; Cell Line; Echocardiography; Endostatins; Heart Failure; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Pulmonary Artery; Rats; Rats, Wistar; Systole | 2016 |
Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Chalcone; Deoxyguanosine; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Male; Malondialdehyde; Monocrotaline; Oxidative Stress; Quinones; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Vascular Remodeling | 2016 |
Preventive aerobic training exerts a cardioprotective effect on rats treated with monocrotaline.
Topics: Aerobiosis; Animals; Cardiotonic Agents; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Physical Conditioning, Animal; Rats, Wistar | 2016 |
Bortezomib alleviates experimental pulmonary hypertension by regulating intracellular calcium homeostasis in PASMCs.
Topics: Animals; Bone Morphogenetic Protein 4; Bortezomib; Calcium; Calcium Signaling; Cell Hypoxia; Cell Proliferation; Homeostasis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia-Inducible Factor 1, alpha Subunit; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Rats; Rats, Sprague-Dawley; TRPC Cation Channels; Up-Regulation | 2016 |
Thymoquinone attenuates monocrotaline-induced pulmonary artery hypertension via inhibiting pulmonary arterial remodeling in rats.
Topics: Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Benzoquinones; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome; Vascular Remodeling | 2016 |
Cardiopulmonary protective effects of the selective FXR agonist obeticholic acid in the rat model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Chenodeoxycholic Acid; Exercise Test; Gene Expression Profiling; Gene Expression Regulation; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Lung; Lung Injury; Male; Monocrotaline; Organ Size; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger | 2017 |
Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Case-Control Studies; Disease Models, Animal; Disease Progression; Endothelin-1; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Liver; Lung; Male; Middle Aged; Monocrotaline; Niacinamide; Nicotinamide N-Methyltransferase; Nitric Oxide; Rats, Wistar; Signal Transduction; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right | 2016 |
A urotensin II receptor antagonist, KR36676, decreases vascular remodeling and inflammation in experimental pulmonary hypertension.
Topics: Acetamides; Animals; Anti-Inflammatory Agents; Benzoxazines; Collagen; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; MAP Kinase Signaling System; Monocrotaline; NF-kappa B; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2016 |
Monocrotaline-Induced Pulmonary Hypertension Involves Downregulation of Antiaging Protein Klotho and eNOS Activity.
Topics: Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Down-Regulation; Glucuronidase; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Klotho Proteins; Male; Mesenchymal Stem Cells; Monocrotaline; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sirtuin 1; Transfection | 2016 |
Cardiac Body Surface Potentials in Rats with Experimental Pulmonary Hypertension during Ventricular Depolarization.
Topics: Animals; Blood Pressure; Electrocardiography; Electrodes; Female; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Lung; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar | 2016 |
Aspirin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing the ERK/MAPK pathway.
Topics: Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Flavonoids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; MAP Kinase Signaling System; Monocrotaline; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Systole; Vascular Remodeling | 2017 |
Cocktail of Superoxide Dismutase and Fasudil Encapsulated in Targeted Liposomes Slows PAH Progression at a Reduced Dosing Frequency.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arterial Pressure; Chemistry, Pharmaceutical; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Liposomes; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Superoxide Dismutase; Vasodilator Agents | 2017 |
Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling.
Topics: Adenoviridae; Animals; Bone Morphogenetic Protein Receptors, Type II; Coculture Techniques; Gene Expression Regulation; Genetic Vectors; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; MicroRNAs; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Inbred Lew; Signal Transduction; STAT3 Transcription Factor; Transfection | 2017 |
5-Aminosalicylic Acid Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats by Increasing the Expression of Nur77.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesalamine; Monocrotaline; NF-kappa B; Nuclear Receptor Subfamily 4, Group A, Member 1; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Survival Rate | 2017 |
Protective effects of aloperine on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Antioxidants; Biomarkers; Dose-Response Relationship, Drug; Echocardiography; Electrocardiography; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Oxidative Stress; Piperidines; Protective Agents; Pulmonary Artery; Pulmonary Circulation; Quinolizidines; Rats; Rats, Sprague-Dawley | 2017 |
Effects of Sevoflurane on Hemodynamics and Inducible Nitric Oxide Synthase/Soluble Guanylate Cyclase Signaling Pathway in a Rat Model of Pulmonary Arterial Hypertension.
Topics: Animals; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Methyl Ethers; Monocrotaline; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sevoflurane; Signal Transduction; Soluble Guanylyl Cyclase; Ventricular Function, Right | 2017 |
Celecoxib but not the combination of celecoxib+atorvastatin prevents the development of monocrotaline-induced pulmonary hypertension in the rat.
Topics: Acetylcholine; Animals; Atorvastatin; Blotting, Western; Body Weight; Caspase 3; Celecoxib; Cyclooxygenase Inhibitors; Disease Progression; Drug Combinations; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Nitric Oxide Synthase Type III; Pulmonary Artery; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Sulfonamides; Survival Analysis; Vasodilator Agents | 2008 |
Effects of TNF-alpha blockade in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Etanercept; Heart Failure; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunoglobulin G; Male; Monocrotaline; Random Allocation; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2008 |
Total ginsenosides inhibit the right ventricular hypertrophy induced by monocrotaline in rats.
Topics: Animals; Blood Pressure; Blotting, Western; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ginsenosides; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mitogen-Activated Protein Kinases; Monocrotaline; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Panax; Poisons; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction | 2008 |
Novel approach with intratracheal administration of microgelatin hydrogel microspheres incorporating basic fibroblast growth factor for rescue of rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Gas Analysis; Body Weight; Disease Progression; Fibroblast Growth Factor 2; Gelatin; Hemodynamics; Hydrogels; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Microspheres; Monocrotaline; Rats; Rats, Wistar; Trachea | 2008 |
Captopril attenuates matrix metalloproteinase-2 and -9 in monocrotaline-induced right ventricular hypertrophy in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blotting, Western; Captopril; Disease Models, Animal; Echocardiography; Fibrosis; Gene Expression Regulation; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Wistar; Ventricular Dysfunction, Right | 2008 |
Molecular and electrical remodeling of L- and T-type Ca(2+) channels in rat right atrium with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Calcium Channels, L-Type; Calcium Channels, T-Type; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Heart Atria; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Monocrotaline; Patch-Clamp Techniques; Rats; Rats, Wistar; RNA, Messenger | 2009 |
Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrot
Topics: Animals; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Image Processing, Computer-Assisted; Imidazoles; Immunohistochemistry; Monocrotaline; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pulmonary Artery; Quinoxalines; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Smad3 Protein; Transforming Growth Factor beta1 | 2009 |
Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling.
Topics: Administration, Oral; Animals; Blood Pressure; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Fibrillar Collagens; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Natriuretic Peptides; Osteopontin; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Rats, Wistar; RNA, Messenger; Sildenafil Citrate; Stroke Volume; Sulfones; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Ventricular Pressure; Ventricular Remodeling | 2009 |
The remodeling of connexin in the hypertrophied right ventricular in pulmonary arterial hypertension and the effect of a dual ET receptor antagonist (bosentan).
Topics: Animals; Bosentan; Connexin 43; Disease Models, Animal; Endothelin Receptor Antagonists; Gap Junctions; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microscopy, Confocal; Microscopy, Electron; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Sulfonamides; Ventricular Remodeling | 2009 |
Galphaq-protein carboxyl terminus imitation polypeptide (GCIP)-27 inhibits right ventricular hypertrophy induced by monocrotaline in rats.
Topics: Animals; GTP-Binding Protein alpha Subunits, Gq-G11; Hemodynamics; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle Cells; Myocardium; Peptide Fragments; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley | 2009 |
Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension.
Topics: Angiotensin I; Animals; Antihypertensive Agents; Apelin; Apelin Receptors; Carrier Proteins; Endothelin-1; Gene Expression Profiling; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intercellular Signaling Peptides and Proteins; Male; Monocrotaline; Myocardium; Peptide Fragments; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; RNA, Messenger; Ventricular Function, Right | 2009 |
Preventive effects of raloxifene, a selective estrogen receptor modulator, on monocrotaline-induced pulmonary hypertension in intact and ovariectomized female rats.
Topics: Animals; Blood Pressure; Body Weight; Endothelin-1; Female; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Organ Size; Ovariectomy; Pulmonary Artery; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Substrate Specificity; Time Factors; Ventricular Dysfunction, Right | 2009 |
Resveratrol inhibits right ventricular hypertrophy induced by monocrotaline in rats.
Topics: Animals; Apoptosis; Cardiotonic Agents; Heart; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes | 2010 |
Propylthiouracil attenuates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Antihypertensive Agents; Arterioles; Caspase 3; Connexin 43; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Matrix Metalloproteinase 9; Monocrotaline; Nitric Oxide Synthase Type III; Propylthiouracil; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha; Ventricular Function, Right; Ventricular Pressure | 2009 |
Alterations in pharmacological action of the right ventricle of monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Body Weight; Cardiotonic Agents; Disease Models, Animal; Electrocardiography; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Myocardial Contraction; Organ Size; Perfusion; Rats; Rats, Wistar; Ventricular Function, Right | 2009 |
Pressure overload-induced right ventricular failure is associated with re-expression of myocardial tenascin-C and elevated plasma tenascin-C levels.
Topics: Animals; Blood Pressure; Gene Expression; Heart Failure; Heart Ventricles; Hypertrophy, Right Ventricular; Immunohistochemistry; Integrins; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocardium; Rats; Rats, Wistar; Tenascin; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2009 |
Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.
Topics: Animals; Arterioles; Cardiac Output; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Extracellular Matrix Proteins; Female; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Lung; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Myocardial Contraction; Myocardium; Pulmonary Alveoli; Pulmonary Artery; Rats; Rats, Wistar; Recovery of Function; RNA, Messenger; Stroke Volume; Time Factors; Transplantation, Homologous; Vascular Endothelial Growth Factor A; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2009 |
Effects of telmisartan on right ventricular remodeling induced by monocrotaline in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Body Weight; Echocardiography; Fibrosis; Histocytochemistry; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocardium; Organ Size; Rats; Rats, Wistar; Stroke Volume; Systole; Telmisartan; Transforming Growth Factor beta1; Ventricular Remodeling | 2009 |
Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Propanolamines; Rats; Rats, Wistar; Sympathetic Nervous System; Ventricular Pressure | 2009 |
Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats.
Topics: Animals; Blood Pressure; Blotting, Western; Cell Proliferation; Disease Models, Animal; Down-Regulation; GATA6 Transcription Factor; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Time Factors | 2009 |
Alterations in dystrophin-related glycoproteins in development of right ventricular failure in rats.
Topics: Animals; Calpain; Dystroglycans; Dystrophin-Associated Protein Complex; Heart Failure; Heart Ventricles; Hemodynamics; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Monocrotaline; Myocardium; Rats; Rats, Wistar; Sarcoglycans; Time Factors; Ventricular Dysfunction, Right | 2009 |
Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure.
Topics: Animals; Antioxidants; Disease Models, Animal; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Organometallic Compounds; Rats; Rats, Wistar; Reactive Oxygen Species; Salicylates; Ventricular Dysfunction, Right; Ventricular Remodeling | 2010 |
The extracellular signal-regulated kinase is involved in the effects of sildenafil on pulmonary vascular remodeling.
Topics: Actins; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Dual Specificity Phosphatase 1; Fluorescent Antibody Technique; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocrotaline; Phosphorylation; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sildenafil Citrate; Sulfones; Vasodilator Agents | 2010 |
Pulmonary hypertension is ameliorated in mice deficient in thrombin-activatable fibrinolysis inhibitor.
Topics: Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Capillary Permeability; Carboxypeptidase B2; Chemokine CCL2; Disease Models, Animal; Fibrinolysis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocrotaline; Platelet-Derived Growth Factor; Pulmonary Artery; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Weight Loss | 2010 |
Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Bone Morphogenetic Protein Receptors, Type II; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endothelial Cells; Gene Transfer Techniques; Genetic Therapy; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-10; Interleukin-6; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Survival Analysis; Tissue Extracts; Transforming Growth Factor beta | 2010 |
Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Disease Models, Animal; Histone Deacetylase Inhibitors; Hypertrophy, Right Ventricular; Ligation; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Valproic Acid | 2010 |
Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Familial Primary Pulmonary Hypertension; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Piperazines; Pulmonary Artery; Purines; Rats; Sildenafil Citrate; Sulfonamides; Sulfones; Vasodilator Agents | 2010 |
PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats.
Topics: Animals; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Magnetic Resonance Imaging; Male; Monocrotaline; Myocardium; Organ Size; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Antagonists; Thiophenes | 2010 |
Early inflammatory response during the development of right ventricular heart failure in a rat model.
Topics: Animals; Autoradiography; Disease Models, Animal; Disease Progression; Gallium Radioisotopes; Gene Expression Profiling; Heart Failure; Hypertrophy, Right Ventricular; Immunochemistry; Inflammation; Male; Monocrotaline; Myocardium; Neutrophil Activation; Peroxidase; Radionuclide Imaging; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Right | 2010 |
Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiac Catheterization; Cardiac Output; Catheterization; Echocardiography; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Magnetic Resonance Imaging; Male; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Thermodilution | 2010 |
Urotensin II receptor antagonist attenuates monocrotaline-induced cardiac hypertrophy in rats.
Topics: Animals; Atrial Function; Atrial Natriuretic Factor; Cardiotonic Agents; Cell Hypoxia; Disease Models, Animal; Humans; Hypertrophy, Right Ventricular; Infusions, Intravenous; Infusions, Subcutaneous; Male; Monocrotaline; Myocardial Contraction; Myocardium; Peptide Fragments; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; Time Factors; Urotensins; Vasoconstriction; Ventricular Function, Right | 2010 |
Systemic evaluation of platelet and leukocyte activation and interaction in a rat model of pulmonary arterial hypertension.
Topics: Animals; Cell Communication; Disease Models, Animal; Flow Cytometry; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Leukocytes; Male; Monocrotaline; Platelet Activation; Rats; Rats, Sprague-Dawley | 2010 |
Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Biomarkers; Blood Pressure; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Male; Malondialdehyde; Monocrotaline; Rats; Rats, Sprague-Dawley; Sodium Chloride; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Treatment of pulmonary arterial hypertension with circulating angiogenic cells.
Topics: Animals; Arteries; Cell Movement; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kaplan-Meier Estimate; Monocrotaline; Rats; Rats, Nude; Stem Cell Transplantation; Stem Cells; Ventricular Remodeling | 2011 |
Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium Channels; Computer Simulation; Disease Models, Animal; Electric Stimulation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Potassium Channels; Rats; Rats, Wistar; Stroke Volume; Tachycardia, Ventricular | 2011 |
Acceleration of Ca2+ waves in monocrotaline-induced right ventricular hypertrophy in the rat.
Topics: Animals; Arrhythmias, Cardiac; Calcium Signaling; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kinetics; Membrane Potentials; Monocrotaline; Myocardial Contraction; Myocardium; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Ventricular Function, Right; Ventricular Pressure | 2011 |
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Cell Degranulation; Cromolyn Sodium; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mast Cells; Monocrotaline; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Rats; Rats, Sprague-Dawley; Ventricular Function, Right; Ventricular Remodeling | 2011 |
Involvement of BMPR2 in the protective effect of fluoxetine against monocrotaline-induced endothelial apoptosis in rats.
Topics: Animals; Apoptosis; beta Catenin; Blood Pressure; Bone Morphogenetic Protein Receptors, Type II; Caspase 3; Cyclic GMP-Dependent Protein Kinases; Endothelial Cells; Fluoxetine; Gene Expression; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Microvessels; Monocrotaline; Phosphorylation; Pulmonary Artery; Rats; Rats, Wistar; Smad1 Protein | 2011 |
A role for coagulation factor Xa in experimental pulmonary arterial hypertension.
Topics: Animals; Blood Coagulation; Enoxaparin; Factor Xa; Factor Xa Inhibitors; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Morpholines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Rivaroxaban; Thiophenes; Thrombosis; Warfarin | 2011 |
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Disease Models, Animal; Echocardiography, Doppler; Endothelin A Receptor Antagonists; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoxazoles; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfones; Time Factors; Ventricular Function, Right; Ventricular Remodeling | 2011 |
Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase.
Topics: Animals; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Mice; Mice, Knockout; Monocrotaline; Mutation; Rats; Superoxide Dismutase | 2011 |
Intralipid prevents and rescues fatal pulmonary arterial hypertension and right ventricular failure in rats.
Topics: Actins; Animals; Apoptosis; Blotting, Western; Caspase 3; Emulsions; Fat Emulsions, Intravenous; Fibrosis; Heart; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Microscopy, Confocal; Monocrotaline; Myocardium; Phospholipids; Platelet Endothelial Cell Adhesion Molecule-1; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Soybean Oil; Vascular Endothelial Growth Factor A | 2011 |
Simvastatin protects against the development of monocrotaline-induced pulmonary hypertension in rats via a heme oxygenase-1-dependent pathway.
Topics: Animals; Arterioles; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-6; Lung; Monocrotaline; Protoporphyrins; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin | 2011 |
Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.
Topics: Animals; Calcium; Disease Models, Animal; Excitation Contraction Coupling; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microscopy, Confocal; Monocrotaline; Myocardial Contraction; Myocytes, Cardiac; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Treatment Outcome; Ventricular Dysfunction, Right; Ventricular Remodeling | 2012 |
Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline.
Topics: Animals; Blotting, Western; Cell Adhesion Molecules; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; I-kappa B Proteins; Inflammation; Male; Mice; Monocrotaline; Myocardium; NF-kappa B; NF-KappaB Inhibitor alpha; Poisons; Real-Time Polymerase Chain Reaction; RNA; Signal Transduction; Ventricular Remodeling | 2012 |
Effects of autologous bone marrow mononuclear cells implantation in canine model of pulmonary hypertension.
Topics: Animals; Bone Marrow Transplantation; Cell Differentiation; Cell Separation; Cell Tracking; Disease Models, Animal; Dogs; Endothelial Cells; Endothelin-1; Flow Cytometry; Fluorescent Antibody Technique; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-6; Monocrotaline; Neovascularization, Physiologic; Pulmonary Artery; RNA, Messenger; Stem Cell Transplantation; Time Factors; Transplantation, Autologous; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Ventricular Function, Right | 2012 |
Monocrotaline-induced pulmonary hypertension in Wistar rats.
Topics: Animals; Antihypertensive Agents; Cardiac Output; Carotid Arteries; Catheterization, Swan-Ganz; Disease Models, Animal; Femoral Artery; Femoral Vein; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Wedge Pressure; Rats; Rats, Wistar | 2009 |
Cardiac and vascular atrogin-1 mRNA expression is not associated with dexamethasone efficacy in the monocrotaline model of pulmonary hypertension.
Topics: Animals; Blood Pressure; Dexamethasone; Disease Models, Animal; Drug Antagonism; Gene Expression; Glucocorticoids; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle Proteins; Myostatin; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; SKP Cullin F-Box Protein Ligases | 2012 |
Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Morpholines; Nitric Oxide; Nitroprusside; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium Nitrite; Tunica Media | 2012 |
Role of Src tyrosine kinases in experimental pulmonary hypertension.
Topics: Animals; Apoptosis; Becaplermin; Benzamides; Cell Proliferation; Cells, Cultured; Chemotaxis; Dasatinib; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Imatinib Mesylate; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Pyrimidines; Rats; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Thiazoles; Time Factors | 2012 |
Attenuation of monocrotaline-induced pulmonary arterial hypertension in rats by rosuvastatin.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Familial Primary Pulmonary Hypertension; Fluorobenzenes; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide Synthase Type III; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Time Factors | 2012 |
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
Topics: Aniline Compounds; Animals; Calcimimetic Agents; Calcium Signaling; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthalenes; Phenethylamines; Propylamines; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; RNA Interference; Spermine; Time Factors; Transfection; Vasoconstriction | 2012 |
Superiority of desflurane over sevoflurane and isoflurane in the presence of pressure-overload right ventricle hypertrophy in rats.
Topics: Anesthetics, Inhalation; Animals; Desflurane; Hypertrophy, Right Ventricular; Isoflurane; Male; Methyl Ethers; Monocrotaline; Random Allocation; Rats; Rats, Wistar; Sevoflurane | 2012 |
Iptakalim ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Endothelin-1; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; KATP Channels; Lung; Male; Monocrotaline; Natriuretic Peptide, Brain; Nitric Oxide; Propylamines; Rats; Rats, Wistar | 2013 |
Additive effect of tadalafil and simvastatin on monocrotaline-induced pulmonary hypertension rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Arterioles; Carbolines; Disease Models, Animal; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Simvastatin; Tadalafil; Time Factors; Vasodilator Agents | 2012 |
Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.
Topics: Animals; Anoctamin-1; Calcium Channel Blockers; Chloride Channel Agonists; Chloride Channels; Cyclooxygenase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indomethacin; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nifedipine; Niflumic Acid; Patch-Clamp Techniques; Pulmonary Artery; Pyrimidines; Rats; Rats, Wistar; Serotonin; Thiazoles | 2012 |
Urotensin inhibition with palosuran could be a promising alternative in pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Arterioles; Endothelin-1; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Quinolines; Rats; Rats, Wistar; Transforming Growth Factor beta1; Urea; Urotensins | 2013 |
Cardiac modulations of ANG II receptor expression in rats with hypoxic pulmonary hypertension.
Topics: Animals; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Ligands; Male; Monocrotaline; Myocardium; Organ Size; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger | 2002 |
Dexfenfluramine protects against pulmonary hypertension in rats.
Topics: Animals; Appetite Depressants; Body Weight; Dexfenfluramine; Eating; Endothelium, Vascular; Female; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Myocardium; Nitric Oxide Synthase; Obesity; Organ Size; Pancreatic Elastase; Pulmonary Artery; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Vascular Diseases | 2002 |
Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats.
Topics: Animals; Chemokine CCL2; Electroporation; Gene Expression; Genetic Therapy; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Intramuscular; Macrophages; Male; Monocrotaline; Monocytes; Plasmids; Pulmonary Circulation; Pulmonary Wedge Pressure; Rats; Rats, Sprague-Dawley; Survival Rate; Transgenes | 2002 |
Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.
Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Disease Models, Animal; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Organ Size; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Treatment Outcome; Tunica Intima | 2002 |
Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure.
Topics: Animals; Binding, Competitive; Cell Membrane; Disease Models, Animal; Eye Proteins; Fluoxetine; G-Protein-Coupled Receptor Kinase 1; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Size; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Neurotransmitter; Rhodopsin; Symporters | 2002 |
Skeletal muscle abnormalities in rats with experimentally induced heart hypertrophy and failure.
Topics: Animals; Disease Models, Animal; Heart Failure; Hypertrophy, Right Ventricular; Monocrotaline; Muscle, Skeletal; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley | 2003 |
Tachykinin dysfunction attenuates monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Body Weight; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Organ Size; Rats; Rats, Wistar; Receptors, Tachykinin; RNA Interference; RNA, Double-Stranded; Substance P; Tachykinins | 2003 |
Effect of a surgical aortocaval fistula on monocrotaline-induced pulmonary hypertension.
Topics: Animals; Aorta, Abdominal; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Blood Pressure; Cardiac Output; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Tunica Intima; Ultrasonography, Doppler; Vena Cava, Inferior | 2003 |
Activation of the right ventricular endothelin (ET) system in the monocrotaline model of pulmonary hypertension: response to chronic ETA receptor blockade.
Topics: Animals; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Endothelins; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Phenylpropionates; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A | 2003 |
Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat.
Topics: Actin Cytoskeleton; Adrenergic beta-Agonists; Animals; Biomechanical Phenomena; Body Weight; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Isoproterenol; Male; Monocrotaline; Myocardial Contraction; Norepinephrine; Organ Size; Rats; Rats, Wistar; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Stress, Mechanical | 2003 |
Contractile reserve but not tension is reduced in monocrotaline-induced right ventricular hypertrophy.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicarbonates; Buffers; Coronary Circulation; HEPES; Hydrogen-Ion Concentration; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardial Contraction; Rats; Rats, Wistar | 2004 |
Estrogen and enalapril attenuate the development of right ventricular hypertrophy induced by monocrotaline in ovariectomized rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Body Weight; Densitometry; Disease Progression; Enalapril; Endothelin-1; Estrogens; Female; Hypertrophy, Right Ventricular; Male; Microscopy, Electron; Monocrotaline; Ovariectomy; Rats; Rats, Sprague-Dawley; Renin; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Sex Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ventricular Remodeling | 2003 |
Progressive development of pulmonary hypertension leading to right ventricular hypertrophy assessed by echocardiography in rats.
Topics: Animals; Disease Models, Animal; Disease Progression; Echocardiography; Echocardiography, Doppler, Pulsed; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar | 2003 |
Effect of nolomirole on monocrotaline-induced heart failure.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Aldosterone; Animals; Ascitic Fluid; Atrial Natriuretic Factor; Body Weight; Disease Models, Animal; Dopamine Agonists; Drug Evaluation, Preclinical; Esters; Female; Heart Atria; Heart Failure; Heart Ventricles; Hypertrophy, Right Ventricular; Indoles; Monocrotaline; Norepinephrine; Pleural Effusion; Rats; Rats, Sprague-Dawley; Tetrahydronaphthalenes | 2004 |
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intracellular Signaling Peptides and Proteins; Male; Monocrotaline; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Survival Rate; Time Factors | 2004 |
Effect of endothelin antagonism on contractility, intracellular calcium regulation and calcium regulatory protein expression in right ventricular hypertrophy of the rat.
Topics: Animals; Blood Pressure; Body Weight; Calcium; Dioxoles; Endothelins; Female; Hypertrophy, Right Ventricular; Monocrotaline; Myocardial Contraction; Organ Size; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum | 2004 |
Right ventricle-sparing heart transplantation effective against iatrogenic pulmonary hypertension.
Topics: Alkylating Agents; Animals; Dogs; Heart Transplantation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Iatrogenic Disease; Monocrotaline | 2004 |
Downregulation of Kv4.2 and Kv4.3 channel gene expression in right ventricular hypertrophy induced by monocrotaline in rat.
Topics: Animals; Blood Pressure; Down-Regulation; Heart Septum; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Potassium Channels; Potassium Channels, Voltage-Gated; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Shal Potassium Channels | 2004 |
Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Therapy, Combination; Gelatinases; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Iloprost; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Muscle, Smooth, Vascular; Naphthyridines; Oxygen; Phosphodiesterase Inhibitors; Pulmonary Artery; Pulmonary Gas Exchange; Pulmonary Heart Disease; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Ventricular Remodeling | 2004 |
Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Atrasentan; Blood Pressure; Body Mass Index; Body Weight; Cardiomegaly; Drug Administration Schedule; Drug Therapy, Combination; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Intubation, Gastrointestinal; Lung; Male; Monocrotaline; Organ Size; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors; Tunica Media; Ventricular Pressure | 2004 |
Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Ghrelin; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Peptide Hormones; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Ventricular Function, Left; Ventricular Function, Right | 2004 |
Disruption of endothelial-cell caveolin-1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Caveolin 1; Caveolins; Disease Models, Animal; DNA-Binding Proteins; Endothelial Cells; Endothelium, Vascular; Heat-Shock Proteins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isomerases; Male; Membrane Microdomains; Mitosis; Monocrotaline; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Proliferating Cell Nuclear Antigen; Protein Disulfide-Isomerases; Protein Processing, Post-Translational; Pulmonary Artery; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Trans-Activators; von Willebrand Factor | 2004 |
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.
Topics: Animals; Apoptosis; Cell Division; Cells, Cultured; Dichloroacetic Acid; Drug Evaluation, Preclinical; Gene Expression Regulation; Heart Failure; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kv1.5 Potassium Channel; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organ Specificity; Oxidative Phosphorylation; Potassium Channels, Voltage-Gated; Pulmonary Artery; Rats; Shab Potassium Channels; Vascular Resistance | 2004 |
[Effect of chronic administration of aminoguanidine on the reactivity of pulmonary vessels in rats with monocrotaline-induced pulmonary hypertension].
Topics: Acetylcholine; Animals; Blood Pressure; Endothelium, Vascular; Guanidines; Guanylate Cyclase; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2004 |
Gene transfer of hepatocyte growth factor with prostacyclin synthase in severe pulmonary hypertension of rats.
Topics: Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Genetic Therapy; Heart Ventricles; Hepatocyte Growth Factor; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intramolecular Oxidoreductases; Monocrotaline; Organ Size; Pulmonary Artery; Rats; Rats, Wistar; Transfection | 2004 |
Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cyclic AMP; Cytochrome P-450 Enzyme System; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intramolecular Oxidoreductases; Lung; Monocrotaline; Muscle, Skeletal; Plasmids; Prognosis; Pulmonary Artery; Rats; Survival Rate; Time Factors | 2004 |
Pressure overload and neurohumoral activation differentially affect the myocardial proteome.
Topics: Amino Acid Sequence; Animals; Blood Pressure; Cell Cycle; Hypertrophy, Right Ventricular; Isoelectric Point; Male; Molecular Sequence Data; Monocrotaline; Muscle Proteins; Myocardium; Neurosecretory Systems; Proteome; Rats; Rats, Wistar | 2005 |
Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension.
Topics: Animals; Animals, Genetically Modified; Arterial Occlusive Diseases; Cell Proliferation; Disease Models, Animal; Hypertension; Hypertrophy, Right Ventricular; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Receptor, Endothelin B; Tunica Intima | 2005 |
Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats.
Topics: 2-Methoxyestradiol; Animals; Blood Pressure; Body Weight; Cell Proliferation; Disease Progression; Estradiol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Time Factors; Tubulin Modulators | 2005 |
Selective right, but not left, coronary endothelial dysfunction precedes development of pulmonary hypertension and right heart hypertrophy in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2006 |
Cardiac hypertrophy induced by prostaglandin F(2alpha) may be mediated by calcineurin signal transduction pathway in rats.
Topics: Animals; Calcineurin; Cells, Cultured; Dinoprost; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 2005 |
Inotropic and lusitropic effects of ghrelin and their modulation by the endocardial endothelium, NO, prostaglandins, GHS-R1a and KCa channels.
Topics: Animals; Apamin; Charybdotoxin; Endocardium; Ghrelin; Humans; Hypertrophy, Right Ventricular; Indomethacin; Monocrotaline; Nitric Oxide; Nitroarginine; Oligopeptides; Peptide Hormones; Peptides; Potassium Channels; Prostaglandins; Rats; Receptors, G-Protein-Coupled; Receptors, Ghrelin | 2006 |
Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blotting, Western; Down-Regulation; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Genistein; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Vascular Resistance | 2006 |
Upregulation of profilin, cofilin-2 and LIMK2 in cultured pulmonary artery smooth muscle cells and in pulmonary arteries of monocrotaline-treated rats.
Topics: Animals; Cells, Cultured; Cofilin 2; Disease Models, Animal; Dogs; Hyperplasia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Lim Kinases; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Profilins; Protein Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha; Up-Regulation | 2006 |
Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Proliferation; Chymases; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Peptidyl-Dipeptidase A; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; RNA, Messenger; Serine Endopeptidases; Tetrazoles; Tunica Media | 2006 |
Remodeling excitation-contraction coupling of hypertrophied ventricular myocytes is dependent on T-type calcium channels expression.
Topics: Animals; Calcium Channels, T-Type; Gene Expression; Heart; Hypertrophy, Right Ventricular; Monocrotaline; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stimulation, Chemical | 2006 |
Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats.
Topics: Animals; Coronary Vessels; Disulfides; Dose-Response Relationship, Drug; Endothelium, Vascular; Garlic; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Plant Extracts; Rats; Rats, Sprague-Dawley; Sulfinic Acids; Time Factors; Vasodilation | 2006 |
Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat.
Topics: Animals; Blood Pressure; Cardiac Output; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Male; Monocrotaline; Organ Size; Rats; Rats, Wistar; Stroke Volume; Time Factors; Ventricular Dysfunction, Right; Ventricular Pressure | 2006 |
2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension.
Topics: 2-Methoxyestradiol; Analysis of Variance; Animals; Blood Pressure; Disease Progression; Estradiol; Female; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Ovariectomy; Pulmonary Artery; Rats; Time Factors; Ventricular Function, Left; Ventricular Function, Right | 2006 |
The HMG-CoA reductase inhibitor, pravastatin, prevents the development of monocrotaline-induced pulmonary hypertension in the rat through reduction of endothelial cell apoptosis and overexpression of eNOS.
Topics: Acetylcholine; Animals; Apoptosis; Blood Pressure; Blotting, Western; Body Weight; Caspase 3; Disease Progression; Endothelial Cells; Heart Function Tests; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; In Situ Nick-End Labeling; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Nitroprusside; Poisons; Pravastatin; Pulmonary Artery; Rats; Rats, Wistar; Survival; Vasodilator Agents | 2006 |
Short-term administration of a cell-permeable caveolin-1 peptide prevents the development of monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
Topics: Amino Acid Sequence; Animals; Biotinylation; Caveolin 1; Cell Membrane Permeability; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Molecular Sequence Data; Monocrotaline; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2006 |
Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat.
Topics: Animals; Blood Pressure; Cardiac Volume; Collagen; Diastole; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Rats; Rats, Wistar; Ventricular Function, Left; Ventricular Function, Right; Ventricular Pressure | 2007 |
Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages; Male; Monocrotaline; Mycophenolic Acid; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley | 2006 |
Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction.
Topics: Acetylcholine; Animals; Blood Pressure; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Paracrine Communication; Phenotype; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Time Factors; Trachea; Vascular Resistance; Vasodilation; Vasodilator Agents | 2007 |
Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.
Topics: Acetylcholine; Animals; Biological Factors; Catalase; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microcirculation; Microscopy, Video; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2007 |
Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats.
Topics: Amidohydrolases; Animals; Arginase; Arginine; Cyclic GMP; Endothelial Cells; Enzyme Activation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isometric Contraction; Lung; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction | 2007 |
Inhibitory effect of ginsenoside Rb1 on cardiac hypertrophy induced by monocrotaline in rat.
Topics: Animals; Atrial Natriuretic Factor; Blotting, Western; Calcineurin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gene Expression Regulation; Ginsenosides; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Panax; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2007 |
Activity of endothelium-derived hyperpolarizing factor is augmented in monocrotaline-induced pulmonary hypertension of rat lungs.
Topics: Animals; Anti-Infective Agents; Apamin; Biological Factors; Charybdotoxin; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfaphenazole; Thapsigargin; Vascular Cell Adhesion Molecule-1; Vasodilation | 2007 |
Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy.
Topics: Adrenergic Fibers; Animals; Dopamine; Endothelin-1; GAP-43 Protein; Gene Expression Regulation; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kinetics; Male; Monocrotaline; Myocytes, Cardiac; Nerve Growth Factor; Neural Cell Adhesion Molecule L1; Norepinephrine; Rats; Rats, Wistar; Sialic Acids; Tubulin; Tyrosine 3-Monooxygenase; Up-Regulation | 2007 |
Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography.
Topics: Action Potentials; Animals; Body Surface Potential Mapping; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardial Contraction; Rats; Rats, Wistar; Severity of Illness Index; Systole; Time Factors; Ultrasonography; Ventricular Function, Right; Ventricular Pressure | 2007 |
Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension.
Topics: Angiography; Animals; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Thromboplastin; Vascular Endothelial Growth Factor Receptor-2; von Willebrand Factor | 2007 |
Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats.
Topics: Adenine Nucleotides; Animals; Blood Pressure; Collagen; Creatine; Dietary Supplements; Folic Acid; Heart Ventricles; Homocysteine; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardial Contraction; Random Allocation; Rats; Rats, Wistar; Ventricular Function, Left; Ventricular Function, Right | 2007 |
Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cell Line; Cytochrome P-450 Enzyme System; Dependovirus; Epoprostenol; Feasibility Studies; Gene Transfer Techniques; Genetic Vectors; Heart Rate; Humans; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Injections, Intramuscular; Intramolecular Oxidoreductases; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Survival Analysis | 2007 |
Oral sildenafil prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Lung Diseases, Interstitial; Male; Monocrotaline; Piperazines; Pulmonary Artery; Pulmonary Emphysema; Purines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sildenafil Citrate; Sulfones; Time Factors; Vasodilator Agents | 2007 |
Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Epoprostenol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Protein Kinase Inhibitors; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2007 |
Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension.
Topics: Animals; Cardiac Output; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Signal Transduction | 2007 |
[Effect of triptolide on the development of monocrotaline-induced pulmonary hypertension in pneumonectomized rat].
Topics: Animals; Antihypertensive Agents; Diterpenes; Epoxy Compounds; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Phenanthrenes; Pneumonectomy; Rats; Rats, Sprague-Dawley | 2007 |
Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.
Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthyridines; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rats | 2008 |
Rosuvastatin provides pleiotropic protection against pulmonary hypertension, right ventricular hypertrophy, and coronary endothelial dysfunction in rats.
Topics: Animals; Blood Pressure; Blotting, Western; Body Weight; Coronary Disease; Endothelium, Vascular; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Organ Size; Poisons; Pyrimidines; Rats; Rats, Sprague-Dawley; Rosuvastatin Calcium; Sulfonamides | 2008 |
Evaluation of olmesartan medoxomil in the rat monocrotaline model of pulmonary hypertension.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imidazoles; Lung; Male; Monocrotaline; Olmesartan Medoxomil; Pulmonary Artery; Rats; Rats, Wistar; Tetrazoles; Time Factors | 2008 |
Pyrrolidine dithiocarbamate restores endothelial cell membrane integrity and attenuates monocrotaline-induced pulmonary artery hypertension.
Topics: Acridines; Animals; Caveolin 1; Cell Membrane; Endothelial Cells; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; I-kappa B Proteins; Luminescent Measurements; Male; Monocrotaline; NF-kappa B; NF-KappaB Inhibitor alpha; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, TIE-2; STAT3 Transcription Factor; Superoxides; Thiocarbamates | 2008 |
Effects of a chronic exercise training protocol on oxidative stress and right ventricular hypertrophy in monocrotaline-treated rats.
Topics: Animals; Catalase; Glutathione Transferase; Hypertrophy, Right Ventricular; Male; Monocrotaline; Oxidative Stress; Physical Conditioning, Animal; Pulmonary Heart Disease; Rats; Rats, Wistar; Superoxide Dismutase; Weight Gain | 2008 |
Calcium transients in single myocytes and membranous ultrastructures during the development of cardiac hypertrophy and heart failure in rats.
Topics: Animals; Calcium; Cell Membrane; Heart Failure; Hypertrophy, Right Ventricular; Isometric Contraction; Isoproterenol; Male; Microscopy, Electron, Scanning; Mitochondria, Heart; Monocrotaline; Myocardial Contraction; Myocardium; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum | 1994 |
Intraventricular changes in the beta-adrenoceptor-adenylate cyclase system of the rat heart with the progress of monocrotaline-induced right ventricular hypertrophy.
Topics: 5'-Nucleotidase; Adenylyl Cyclases; Animals; Cell Membrane; Heart Septum; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Sodium-Potassium-Exchanging ATPase | 1994 |
Activation of ANP synthesis during congestive heart failure in rats treated with monocrotaline.
Topics: Animals; Ascitic Fluid; Atrial Natriuretic Factor; Cardiomegaly; Female; Gene Expression; Heart Failure; Hypertrophy, Right Ventricular; Monocrotaline; Myocardium; Organ Specificity; Pleural Effusion; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline.
Topics: Animals; Blood Pressure; Disease Models, Animal; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Interleukin; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins | 1994 |
Contrasting effects of an angiotensin converting enzyme inhibitor and a calcium antagonist on calcium transients in isolated rat cardiac myocytes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Hypertrophy, Right Ventricular; Indans; Male; Monocrotaline; Myocardial Contraction; Myocardium; Nifedipine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta | 1994 |
Interleukin-1 receptor antagonist inhibits pulmonary hypertension induced by inflammation.
Topics: Animals; Blood Pressure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lung; Male; Monocrotaline; Organ Size; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; RNA, Messenger; Sialoglycoproteins | 1994 |
Cardiovascular responses to hemorrhage during acute and chronic hypoxia.
Topics: Acute Disease; Animals; Blood Volume; Cardiovascular System; Chronic Disease; Gases; Hematocrit; Hemodynamics; Hemorrhage; Hypertrophy, Right Ventricular; Hypoxia; Male; Monocrotaline; Rats; Rats, Sprague-Dawley | 1994 |
Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Gene Expression; Growth Substances; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1993 |
Protection by oestradiol against the development of cardiovascular changes associated with monocrotaline pulmonary hypertension in rats.
Topics: Animals; Behavior, Animal; Body Weight; Drug Implants; Estradiol; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Organ Size; Pulmonary Artery; Pulmonary Circulation; Pulmonary Edema; Rats; Rats, Sprague-Dawley | 1993 |
Cardiac atrial natriuretic peptide in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Disease Models, Animal; Heart Atria; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Endothelin-1; Endothelins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Lung; Male; Monocrotaline; Peptides, Cyclic; Protein Precursors; Pulmonary Artery; Rats; Rats, Wistar; RNA, Messenger; Vasoconstriction | 1993 |
Strain differences in the response of Fischer 344 and Sprague-Dawley rats to monocrotaline induced pulmonary vascular disease.
Topics: Animals; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Species Specificity; Weight Gain | 1993 |
Role of nitric oxide and endothelin-1 in monocrotaline-induced pulmonary hypertension in rats.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arginine; Calcimycin; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Indomethacin; Male; Monocrotaline; Nitric Oxide; Nitroglycerin; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vasodilation | 1995 |
Right heart failure chronically stimulates heat shock protein 72 in heart and liver but not in other tissues.
Topics: Animals; Autoradiography; Blotting, Western; Female; Heart Failure; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Hypertrophy, Right Ventricular; Liver; Lung; Monocrotaline; Muscle, Skeletal; Myocardium; Norepinephrine; Rats; Rats, Sprague-Dawley | 1996 |
[Role of peptide leukotrienes in monocrotaline-induced lung disease].
Topics: Animals; Chromones; Hypertrophy, Right Ventricular; Leukotriene C4; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 1995 |
Induction of right ventricular hypertrophy in neonatal guinea pigs by monocrotaline.
Topics: Animals; Disease Models, Animal; Guinea Pigs; Humans; Hypertrophy, Right Ventricular; Monocrotaline; Poisons | 1996 |
Role of inhibition of nitric oxide production in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Arterioles; Blood Pressure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Male; Molsidomine; Monocrotaline; Nitrates; Nitric Oxide; Poisons; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Weight Gain | 1997 |
Stage-dependent changes in membrane currents in rats with monocrotaline-induced right ventricular hypertrophy.
Topics: Action Potentials; Animals; Electric Conductivity; Hypertrophy, Right Ventricular; Male; Membranes; Monocrotaline; Myocardium; Patch-Clamp Techniques; Rats; Rats, Wistar; Reference Values; Ventricular Function | 1997 |
The orally active ET(A) receptor antagonist (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphe nyl-propionic acid (LU 135252) prevents the development of pulmonary hypertension and endothelial metabolic dysfunction in monocrotaline-treated ra
Topics: Administration, Oral; Animals; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Peptidyl-Dipeptidase A; Phenylpropionates; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Ventricular Function, Right | 1997 |
Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension.
Topics: Actins; Animals; Disease Models, Animal; Hemodynamics; Hyperplasia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Tunica Intima | 1997 |
Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Antihypertensive Agents; Bosentan; Cardiac Output; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Neovascularization, Pathologic; Organ Size; Poisons; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
Cardiac and vascular responses after monocrotaline-induced hypertrophy in rats.
Topics: Animals; Body Weight; Disease Models, Animal; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardial Contraction; Poisons; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Stimulation, Chemical; Vasoconstriction | 1998 |
Endothelin converting enzyme inhibitor protects development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Aspartic Acid Endopeptidases; Blood Pressure; Endothelin-Converting Enzymes; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Male; Metalloendopeptidases; Monocrotaline; Organ Size; Poisons; Pulmonary Artery; Rats; Rats, Wistar; Tetracyclines | 1998 |
Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline.
Topics: Adrenomedullin; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Infusion Pumps, Implantable; Lung; Male; Monocrotaline; Organ Size; Peptides; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar | 1998 |
[Preventive effects of tetrandrine on pulmonary hypertension and right ventricular hypertrophy in rats induced by monocrotaline].
Topics: Alkaloids; Animals; Benzylisoquinolines; Blood Pressure; Calcium Channel Blockers; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Wistar | 1996 |
Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension.
Topics: Animals; Enzyme Inhibitors; Guanidines; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Male; Monocrotaline; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Pulmonary Circulation; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution; Vasomotor System | 1999 |
Endothelin-1 is elevated in monocrotaline pulmonary hypertension.
Topics: Angiotensin II; Animals; Drug Combinations; Endothelin-1; Endothelins; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Lung; Male; Monocrotaline; Oligopeptides; omega-N-Methylarginine; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Vasoconstriction | 1999 |
Tetrandrine inhibited chronic "inflammatory" pulmonary hypertension in rats.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylisoquinolines; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Wistar | 1997 |
Dietary retinol inhibits inflammatory responses of rats treated with monocrotaline.
Topics: Animals; Carcinogens; Diet; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Injections, Subcutaneous; Lung; Male; Monocrotaline; Pulmonary Artery; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; Vitamin A | 1999 |
Impaired endothelium-dependent relaxation by adrenomedullin in monocrotaline-treated rat arteries.
Topics: Acetylcholine; Adrenomedullin; Animals; Aorta, Thoracic; Body Weight; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Organ Size; Peptides; Pulmonary Artery; Rats; Rats, Wistar; Time Factors; Vasodilation; Vasodilator Agents | 1999 |
Dietary beta-carotene protects lung and liver parenchyma of rats treated with monocrotaline.
Topics: Animals; Antidotes; Antioxidants; beta Carotene; Chemical and Drug Induced Liver Injury; Collagen; Diet; Fatty Liver; Hemorrhage; Hypertrophy, Right Ventricular; Liver; Lung; Lung Diseases; Male; Monocrotaline; Poisons; Rats; Rats, Sprague-Dawley | 1999 |
Apoptosis and atrophy in rat slow skeletal muscles in chronic heart failure.
Topics: Animals; Apoptosis; Atrophy; Blotting, Western; Body Weight; Caspase 3; Caspases; Cell Nucleus; Chronic Disease; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Male; Monocrotaline; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Myosin Heavy Chains; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Ubiquitins | 1999 |
(+)-[3H]isradipine and [3H]glyburide bindings to heart and lung membranes from rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Calcium Channels, L-Type; Glyburide; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoglycemic Agents; In Vitro Techniques; Isradipine; KATP Channels; Kinetics; Lung; Male; Membranes; Monocrotaline; Myocardium; Poisons; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley | 1999 |
Cardiac endothelin and big endothelin in right-heart hypertrophy due to monocrotaline-induced pulmonary hypertension in rat.
Topics: Analysis of Variance; Angiotensin II; Animals; Atrial Natriuretic Factor; Endothelin-1; Endothelins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Myocardium; Perfusion; Poisons; Protein Precursors; Rats; Rats, Sprague-Dawley | 1999 |
Remodeling of gap junctional coupling in hypertrophied right ventricles of rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Cell Communication; Gap Junctions; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Male; Monocrotaline; Rats; Rats, Wistar | 2000 |
Effects of concentrated ambient particles in rats and hamsters: an exploratory study.
Topics: Age Factors; Air Pollutants; Air Pollution; Animals; Blood Cell Count; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart Rate; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Maximum Allowable Concentration; Mesocricetus; Monocrotaline; Mortality; Particle Size; Rats; Rats, Inbred F344; Time Factors | 2000 |
Calcium handling and role of endothelin-1 in monocrotaline right ventricular hypertrophy of the rat.
Topics: Animals; Calcium; Calcium Signaling; Diastole; Endothelin-1; Hypertrophy, Right Ventricular; Ion Transport; Monocrotaline; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Systole; Ventricular Function, Right | 2000 |
Enhanced expression and activity of xanthine oxidoreductase in the failing heart.
Topics: Animals; Coronary Vessels; Disease Models, Animal; Disease Progression; Enzyme Induction; Female; Free Radicals; Heart Failure; Heart Ventricles; Hypertrophy, Right Ventricular; Ligation; Monocrotaline; Muscle Proteins; Myocardial Infarction; Organ Size; Rats; Rats, Sprague-Dawley; Xanthine Oxidase | 2000 |
Chronic treatment with probucol effectively inhibits progression of pulmonary hypertension in rats.
Topics: Animals; Anticholesteremic Agents; Blood Pressure; Diet; Disease Progression; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Probucol; Rats; Rats, Wistar; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure | 2000 |
Endothelin-A-receptor antagonist and oral prostacyclin analog are comparably effective in ameliorating pulmonary hypertension and right ventricular hypertrophy in rats.
Topics: Administration, Oral; Animals; Endothelin Receptor Antagonists; Epoprostenol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Sulfonamides | 2000 |
Capsaicin pre- and post-treatment on rat monocrotaline pneumotoxicity.
Topics: Animals; Capsaicin; Functional Residual Capacity; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Neprilysin; Neurokinin A; Organ Size; Rats; Rats, Sprague-Dawley; Substance P; Total Lung Capacity | 2000 |
Beneficial effects on skeletal muscle of the angiotensin II type 1 receptor blocker irbesartan in experimental heart failure.
Topics: Angiotensin II; Animals; Apoptosis; Biphenyl Compounds; Calcium Channel Blockers; Drug Evaluation, Preclinical; Gene Expression Regulation; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Infusion Pumps, Implantable; Irbesartan; Male; Monocrotaline; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Nifedipine; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Tetrazoles; Tumor Necrosis Factor-alpha | 2001 |
Enhanced gene expression of renin-angiotensin system, TGF-beta1, endothelin-1 and nitric oxide synthase in right-ventricular hypertrophy.
Topics: Animals; Disease Models, Animal; Endothelin-1; Gene Expression; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Attenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+-H+ exchange inhibitor cariporide.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Natriuretic Factor; Cell Size; Enzyme Inhibitors; Guanidines; Heart Failure; Hemodynamics; Hypertrophy, Right Ventricular; Lung; Lung Diseases; Male; Monocrotaline; Myocardium; Organ Size; Poisons; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium-Hydrogen Exchangers; Sulfones | 2001 |
Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dietary Fats; Disease Models, Animal; Enalapril; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Lung; Magnetic Resonance Imaging; Male; Monocrotaline; Nitrates; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Perfusion; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2001 |
Time- and subunit-dependent differential mRNA expression of L-type Ca2+ channel during progression of right ventricular hypertrophy.
Topics: Animals; Blotting, Northern; Calcium Channels, L-Type; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2001 |
Defective intracellular calcium handling in monocrotaline-induced right ventricular hypertrophy: protective effect of long-term endothelin-A receptor blockade with 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy-phenyl-)- 4-oxobut-2-enoate-sodium (PD 155080
Topics: Aequorin; Animals; Calcium; Calcium Signaling; Dioxoles; Endothelin Receptor Antagonists; Endothelin-1; Female; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Luminescent Measurements; Monocrotaline; Myocardial Contraction; Perfusion; Poisons; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Ventricular Function, Right | 2002 |
Changes in alpha(1)-adrenergic vascular reactivity in monocrotaline-treated rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Mesenteric Arteries; Monocrotaline; Norepinephrine; Piperazines; Pulmonary Artery; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Thoracic Arteries; Vasoconstriction | 2002 |
The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Cardiopulmonary Bypass; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoproterenol; Male; Monocrotaline; Nitroglycerin; Propranolol; Rabbits; Vasoactive Intestinal Peptide; Vasodilator Agents; Verapamil | 2002 |
Attenuation of negatively regulated ANP secretion by calcium in hypertrophied atria.
Topics: Animals; Atrial Natriuretic Factor; Calcium; Calcium Signaling; Dose-Response Relationship, Drug; Feedback, Physiological; Heart Atria; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Myocardial Contraction; Myocardium; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 2002 |
Dietary fish oil protects against lung and liver inflammation and fibrosis in monocrotaline treated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dietary Fats; Fatty Acids, Unsaturated; Fish Oils; Histocytochemistry; Hypertrophy, Right Ventricular; Liver; Liver Cirrhosis; Lung; Male; Monocrotaline; Pneumonia; Pulmonary Fibrosis; Random Allocation; Rats; Rats, Sprague-Dawley | 2002 |
Monocrotaline-induced structural remodeling of the intra-acinar pulmonary arteries and pulmonary hypertension.
Topics: Animals; Arterioles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Alveoli; Pulmonary Artery; Rats; Rats, Wistar | 1992 |