monocrotaline has been researched along with Hypertension, Pulmonary in 1089 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 72 (6.61) | 18.7374 |
| 1990's | 147 (13.50) | 18.2507 |
| 2000's | 229 (21.03) | 29.6817 |
| 2010's | 496 (45.55) | 24.3611 |
| 2020's | 145 (13.31) | 2.80 |
| Authors | Studies |
|---|---|
| Ben Fadel, N; Deng, Y; Jankov, RP; Lesage, F; Renesme, L; Sauvestre, F; Stewart, DJ; Thébaud, B; Vadivel, A; Zhong, S | 1 |
| Brodaczewska, K; Kieda, C; Mackiewicz, U; Mączewski, M; Oknińska, M; Paterek, A; Szczylik, C; Torbicki, A; Zajda, K; Zambrowska, Z | 1 |
| Evlakhov, VI; Ovsiannikov, VI; Poiasov, IZ | 1 |
| Chen, W; Lian, G; Luo, L; Wang, H; Wang, T; Xiao, G; Xie, L; Zhuang, W | 1 |
| Araujo, A; Campos, C; Corssac, G; Klein, AB; Lacerda, D; Llesuy, S; Tavares, AMV; Turck, P | 1 |
| Ding, D; He, Y; Jiang, H; Li, X; Liu, X; Xu, Y | 1 |
| Eklund, M; Khoruts, A; Moutsoglou, DM; Prins, KW; Prisco, AR; Prisco, SZ; Thenappan, T; Weir, EK | 1 |
| Balis, P; Doka, G; Klimas, J; Kmecova, Z; Krenek, P; Malikova, E; Pivackova, LB; Trubacova, S; Velasova, E | 1 |
| Bagchi, AK; Farahmand, F; Malik, A; Sharma, A; Singal, PK | 1 |
| Azevedo, HS; He, W; Huang, F; Li, B; Li, Y; Lin, C; Teng, C; Xing, X; Yang, Y | 1 |
| Chen, W; Chen, Z; Cheng, S; Hu, S; Li, H; Ouyang, M; Peng, H; Xue, J; Yu, S; Zeng, W; Zhang, Y; Zhou, L | 1 |
| Bonnet, S; Lemay, SE; Potus, F | 1 |
| Dai, C; Fang, J; Huang, H; Kong, B; Qin, T; Shuai, W; Xiao, Z | 1 |
| Goshima, Y; Goto, T; Hashimoto, T; Koga, M; Masukawa, D; Matsushita, N; Miyazaki, T; Mizuno, Y; Nakamura, F; Nakano, M; Niikura, R; Saito, M; Shimizu, T; Tamura, K; Uchimura, H; Zou, S | 1 |
| Hu, Z; Jia, Q; Mao, W; Song, N | 1 |
| Chen, D; Chen, Y; Du, G; Fang, L; Niu, Z; Yuan, T; Zhang, H | 1 |
| Adekunle, AO; Adu-Amankwaah, J; Adzika, GK; Duah, M; Ma, Y; Mprah, R; Ndzie Noah, ML; Okwuma, JD; Qiao, W; Wang, C; Wowui, PI | 1 |
| Fujii, S; Fukuda, M; Kato, T; Kobayashi, S; Mikawa, M; Nakamura, Y; Nawata, J; Oda, T; Okamura, T; Okuda, S; Suetomi, T; Tanaka, S; Uchinoumi, H; Yamamoto, T; Yano, M | 1 |
| Jasińska-Stroschein, M | 1 |
| Chen, D; Du, GH; Fang, LH; Lyu, Y; Sun, SC; Wang, RR; Wang, SB; Yuan, TY; Zhang, HF | 1 |
| Huang, QH; Jiao, HX; Lai, SM; Lin, MJ; Yan, FR; Zheng, SY; Zhu, ZL; Zhuang, XL | 1 |
| Deng, Y; Guo, SL; Lan, WF; Li, JQ; Liao, J; Wu, DD; Xie, SS; Zhou, YC | 1 |
| Cao, Y; Jia, Z; Lin, S; Mao, J; Wang, C; Wang, L; Wang, S; Wang, X; Yan, H; Zhang, Z | 1 |
| Kabwe, JC; Kawai, M; Maruyama, J; Maruyama, K; Okada, A; Sawada, H; Zhang, E | 1 |
| Chen, S; Ge, J; Guan, L; Jin, Q; Li, M; Li, W; Long, Y; Yang, L; Zhang, L; Zhou, D | 1 |
| Chen, A; Chen, W; Gong, J; Lian, G; Luo, L; Wang, H; Wang, T; Xie, L; Ye, C | 1 |
| Bai, YZ; Cao, YQ; Dong, WP; Dong, Z; Liu, Y; Ma, XM; Wang, XW; Yang, B; Yang, DP; Yang, YC; Zeng, YY | 1 |
| Bai, P; Li, F; Li, M; Li, X; Liu, C; Liu, H; Liu, J; Lyu, A; Ou, Y; Rong, W; Wan, N; Wang, L; Wei, L; Wu, X; Xing, M; Zhang, H; Zhao, X; Zhu, W | 1 |
| Dohi, K; Hirayama, M; Ito, H; Kabwe, JC; Ko, H; Maruyama, J; Maruyama, K; Mashimo, T; Mitani, Y; Miyasaka, Y; Nishimura, Y; Ohashi, H; Okamoto, R; Oshita, H; Otsuki, S; Oya, K; Sawada, H; Tsuboya, N; Yodoya, N; Zhang, E | 1 |
| Fu, Q; He, J; Li, M; Peng, J; Tan, S; Tang, M; Tang, Y; Xie, W; Xu, X; Zhang, Q; Zhang, Y; Zheng, Z; Zhu, T | 1 |
| Lookin, O; Mukhlynina, E; Protsenko, Y | 1 |
| Chen, X; Han, X; Liu, X; Qu, C; Ran, Q; Shi, S; Sun, Y; Wan, W; Wang, X; Yang, B; Ye, T; Zhang, C; Zhao, X | 1 |
| Adeoti, AO; Channa, ML; Nadar, A | 1 |
| Cao, Y; Chen, F; Chu, C; Fulton, D; Hu, L; Huang, H; Li, K; Li, Y; Lin, D; Qin, L; Shen, Y; Wang, J; Wang, X; Yu, Y; Zhang, H | 1 |
| Han, H; He, M; Hu, S; Kong, H; Tan, Q; Wang, H; Wang, J; Wang, Y; Wu, X; Xie, W; Xu, J; Yang, M; Yu, M | 1 |
| Jiang, C; Lu, S; Ma, X; Wang, XE; Xie, LX | 1 |
| Fang, X; He, C; Li, Q; Long, W; Luo, Y; Ni, X; Wu, R; Zhang, T | 1 |
| Baranowska-Kuczko, M; Jastrząb, A; Kasacka, I; Kozłowska, H; Krzyżewska, A | 1 |
| Li, G; Liu, S; Sun, Y; Zhang, X | 1 |
| He, X; Hu, L; Li, L; Li, Q; Li, X; Shen, J; Tang, S; Tettey, AT; Wang, Y; Wang, Z; Wu, C; Yin, M; Zhao, C | 1 |
| Carter, LL; Clemons, B; Douthitt, A; Galkin, A; Gandjeva, A; Garcia, E; Guimond, D; Kennedy, M; Osterhout, R; Salter-Cid, L; Sitapara, R; Slee, D; Tuder, RM; Zisman, LS | 1 |
| Al-Qazazi, R; Archer, SL; Bentley, RET; Bonnet, S; Chen, KH; Dasgupta, A; Jones, O; Lima, PDA; Martin, AY; Maurice, DH; Mewburn, J; Potus, F; Prins, KW; Prisco, SZ; Provencher, S; Tian, L; Wu, D | 1 |
| Hu, X; Jiang, R; Liu, J; Wang, L; Wang, Q; Wu, W; Yuan, P; Zhao, H; Zhao, Q | 1 |
| Hu, Y; Jin, L; Pan, Y; Wang, Z; Zou, J | 1 |
| Bao, C; Chen, J; Han, Y; He, Q; Hu, Y; Liang, S; Luo, A; Nahar, T; Pan, Y; Sun, Y; Tang, H; Wang, H; Xu, Y; Zheng, S | 1 |
| Chen, X; Chen, XX; Gu, Q; He, JG; Huang, L; Li, L; Li, Y; Meng, XM; Qian, YL; Quan, RL; Wang, PH; Yang, J; Zhou, JJ | 1 |
| Bai, X; Bi, YW; Bing, WD; Jiang, DT; Qu, QX; Song, GM; Sun, WY; Tuo, L; Zhao, X | 1 |
| Feng, Y; Gao, X; Hao, X; Li, L; Long, Y; Zhang, J; Zhang, S; Zhang, X | 1 |
| Fang, C; Liu, C; Liu, K; Lv, X; Ma, Z; Wei, R | 1 |
| Chen, J; Chen, Y; Li, J; Li, Z; Luo, J; Qiu, H; Tang, Y; Yang, X | 1 |
| Aliotta, J; Baird, G; Banerjee, D; Braza, J; Choudhary, G; Harrington, EO; Klinger, JR; Lee, CG; Lu, Q; Nakajima, E; Norbrun, C; Pereira, M; Rounds, S; Sorkhdini, P; Sun, X; Vang, A; Ventetuolo, CE; Yang, AX; Yang, D; Yao, H; Zhou, Y | 1 |
| Feng, Z; Fu, G; Gong, Y; Jiang, D; Jin, T; Lu, J; Lv, Q; Wang, M; Ying, H | 1 |
| Guignabert, C; Humbert, M; Kolkhof, P; Lombès, M; Ottaviani, M; Perrot, J; Ponsardin, E; Thuillet, R; Tu, L; Viengchareun, S | 1 |
| Aryan, L; Eghbali, M; Li, M; Medzikovic, L; Ruffenach, G | 1 |
| Bharati, P; Gaikwad, AN; Hanif, K; Jagavelu, K; Khandelwal, N; Lone, ZR; Mahapatra, S; Rai, P; Shafiq, M | 1 |
| Bisserier, M; Bonnet, S; Boucherat, O; Hadri, L | 1 |
| Chuang, KH; Gui, LX; Jiang, YN; Lin, MJ; Yao, RH; Zheng, SY | 1 |
| Carneiro-Júnior, MA; Drummond, FR; Ervilha, LOG; Freitas, MO; Leite, LB; Natali, AJ; Neves, MM; Portes, AMO; Reis, ECC; Rezende, LMT; Silva, BAFD; Soares, LL | 1 |
| Chen, S; Cui, H; Du, GQ; Li, Y; Shen, W; Sun, P; Wang, C; Xue, JY; Zhao, P | 1 |
| Cao, M; Li, S; Liu, H; Luan, J; Wang, J; Xue, Y; Zhai, C; Zhang, N; Zhang, Q; Zhu, Y | 1 |
| Gokcen, T; Inci, EE; Inci, K; Serdar, U; Sevgen, O | 1 |
| Bao, C; Chen, A; Han, Y; Liang, S; Pan, Y; Tang, H; Wang, X | 1 |
| Duarte, JA; Ferreira, R; Leite-Moreira, A; Morais, F; Moreira-Gonçalves, D; Nogueira-Ferreira, R; Rocha, H; Santos, M; Silva, AF; Vilarinho, L | 1 |
| Gu, L; Liu, CJ; Liu, HM; Xie, L; Yu, L | 1 |
| Lin, S; Ma, H; Ye, P; Yu, WD; Zhang, AK; Zheng, YG | 1 |
| Carvalho, MR; Martinez, PF; Ogura, AY; Oliveira-Junior, SA | 1 |
| Bao, S; Lı, N; Lı, X; Lı, Y; Qı, L; Shı, Y; Sun, L; Wang, M; Xue, M; Yan, S; Yın, J; Zhang, J; Zhang, Q; Zhang, Y | 1 |
| Arava, SK; Arya, DS; Bhatia, J; Hote, MP; Mridha, AR; Seth, S; Shah, S; Vishwakarma, VK; Yadav, HN; Yadav, RK | 1 |
| Abid, S; Adnot, S; Beaulieu, D; Bernard, D; Born, E; Breau, M; Bulavin, DV; Delcroix, M; Derumeaux, G; Do Cruzeiro, M; Flaman, JM; Gil, J; Houssaini, A; Lefevre, M; Lipskaia, L; Marcos, E; Pierre, R; Quarck, R; Reen, V | 1 |
| Dai, P; Deng, Y; Lan, WF; Liao, J; Meng, H; Wu, DD; Xie, SS | 1 |
| Baranowska-Kuczko, M; Kasacka, I; Kozłowska, H; Krzyżewska, A | 2 |
| Liu, Y; Nie, X; Qi, Y; Shang, J; Wu, Z; Zhu, L | 1 |
| Abdulkareem, AO; Chanda, D; Gupta, S; Hanif, K; Iqbal, H; Jagavelu, K; Jha, RK; Lone, ZR; Tiwari, P | 1 |
| Gralinski, MR; Neves, LAA; Rosas, PC; Senese, PB | 1 |
| de Lima Conceição, MR; Leal-Silva, P; Roman-Campos, D; Teixeira-Fonseca, JL | 1 |
| Li, Y; Liu, Y; Qin, H; Xue, Z; Yang, J; Zhou, M; Zhu, Y | 1 |
| Ajijola, OA; Banerjee, S; Fishbein, G; Hong, J; Magaki, S; Razee, A; Umar, S | 1 |
| Cui, L; Li, L; Ma, Q; Mou, J; Sun, G; Wang, M; Zhang, Q; Zhang, X | 1 |
| Fan, C; Li, J; Mei, F; Wang, S; Xi, R; Yang, J; Yin, Q; Yu, Y; Zhang, S; Zhang, X | 1 |
| Chen, L; Fan, F; Guan, Y; He, H; Liu, M; Qiu, L; Yang, G; Zheng, F | 1 |
| Balakin, AA; Gerzen, OP; Kuznetsov, DA; Lisin, RV; Mukhlynina, EA; Nikitina, LV; Protsenko, YL | 1 |
| Musch, TI; Schulze, KM | 1 |
| Chai, L; Chen, H; Chen, Y; Feng, W; Li, D; Li, M; Liu, J; Qiu, Y; Shen, N; Shi, X; Wang, Q; Wang, Y; Xie, X; Zhang, Q | 1 |
| Beserra, SS; de Lima Conceição, MR; Joviano-Santos, JV; Leal-Silva, P; Marques, LP; Roman-Campos, D; Souza, DS; Teixeira-Fonseca, JL | 1 |
| Li, Y; Su, H; Wang, J; Wang, S; Yan, C; Ying, K; Zhu, H | 1 |
| Araujo, ASDR; Belló-Klein, A; Campos-Carraro, C; de Lima-Seolin, BG; Teixeira, RB; Turck, P; Zimmer, A | 1 |
| Cao, N; Chen, AD; Han, Y; Liu, XX; Pan, Y; Qi, ZB; Zhang, F | 1 |
| Song, ZY; Tian, YN; Wang, WT; Wang, XT; Wang, XY; Xu, JP; Yuan, LB; Zhang, S | 1 |
| Conceição, MRL; Joviano-Santos, JV; Machado, FS; Roman-Campos, D; Silva, PLD; Teixeira-Fonseca, JL | 1 |
| Artigues, E; Cortijo, J; Escrivá, J; Milara, J; Montero, P; Perez-Vizcaino, F; Roger, I | 1 |
| Cai, Q; Chen, L; Li, X; Tang, L; Wang, X; Yang, Y | 1 |
| Chen, J; Chen, X; Feng, J; Liu, Z; Luo, Y; Teng, X; Yan, X; Yang, S; Zhang, L; Zhao, S | 1 |
| Hanif, K; Jagavelu, K; Shafiq, M; Singh, N | 1 |
| Bu, D; Chen, S; Du, J; Huang, Y; Jin, H; Kong, W; Liu, X; Tang, C; Tang, X; Tao, Y; Wang, X; Yang, G; Yu, W; Zhang, D; Zhang, H | 1 |
| Campagnac, M; Cardouat, G; Cussac, LA; Ducret, T; Gailly, P; Guibert, C; Marthan, R; Montillaud, A; Quignard, JF; Robillard, P; Savineau, JP; Tiruchellvam Pillai, N | 1 |
| Feng, Q; Qian, X; Zhao, H | 1 |
| Cook, T; Daniell, H; Fisher, A; Gonnella, PA; Habibi, P; Kawut, SM; Lahm, T; Mangu, V; Park, J; Shi, Y; Yakubov, B; Zeng, L | 1 |
| Goshima, M; Kakuda, C; Kodama, T; Okada, M; Omori, A; Otani, K; Yamawaki, H | 1 |
| Black, SM; Chen, J; Chen, X; Chen, Y; Desai, AA; Duan, X; Garcia, JGN; He, W; Hong, C; Hou, C; Kuang, M; Li, M; Liao, J; Liu, C; Liu, S; Lu, W; Makino, A; Rischard, F; Tang, H; Vanderpool, RR; Wang, J; Wu, X; Yang, K; Yuan, JX; Zhang, J; Zhang, N; Zhang, Z; Zheng, Q; Zhong, N; Zou, G | 1 |
| Huang, J; Iacobas, DA; Iacobas, S; Mathew, R | 1 |
| Chen, W; Lei, C; Ouyang, S; Zeng, G | 1 |
| Dong, L; Li, CW; Li, SQ; Wei, XM; Wumaier, G; Xia, JW; Zhang, P; Zhang, XJ; Zhang, YY; Zhang, YZ; Zhu, N | 1 |
| Chen, X; Dong, F; Guo, Z; Peng, Y; Zhang, J; Zhang, S; Zhu, L | 1 |
| Ba, HX; Cao, YY; Li, XH; Li, Y; Luo, ZQ; Tang, SY | 1 |
| Eccles, CA; James, J; Kurdyukov, S; Niihori, M; Rafikov, R; Rafikova, O; Varghese, MV | 1 |
| Araujo, ASDR; Bassani, VL; Belló-Klein, A; Bianchi, S; Campos-Carraro, C; de Castro, AL; Hickmann, A; Lacerda, D; Ortiz, V; Türck, P | 1 |
| Archer, SL; Bonnet, S; Chen, KH; Dasgupta, A; Hindmarch, CCT; Hong, Z; Kutty, S; Lima, PDA; Mewburn, J; Potus, F; Provencher, S; Sutendra, G; Tian, L; Wu, D; Zhao, YY | 1 |
| Huang, W; Kong, H; Liu, P; Peng, LY; Xie, WP; Yang, MX; Yu, M; Zhou, H | 1 |
| Bai, L; Chen, S; Chou, CH; Cui, X; Fan, F; Gongol, B; Gu, M; He, M; He, Y; Huang, HD; Jing, ZC; Lei, Y; Li, Z; Malhotra, A; Miao, Y; Rabinovitch, M; Shen, Y; Shyy, JY; Wang, X; Yan, X; Zhang, J; Zhang, Y | 1 |
| Huang, B; Jiang, B; Miao, H; Qiu, F; Yuan, Y; Zhang, Y; Zhu, L | 1 |
| Avdeev, S; Ergün, S; Ghofrani, HA; Herden, C; Karnati, S; Kosanovic, D; Neupane, B; Pradhan, K; Schermuly, RT; Sydykov, A; Vroom, C | 1 |
| Arent, Z; Bielawska, J; Frączek, P; Hołda, MK; Kopeć, G; Nowakowski, M; Palka, N; Podolec, P; Sowińska, N; Szczepanek, E; Wojtysiak, D | 1 |
| Jankowski, Z; Kocić, I; Sztormowska-Achranowicz, K | 1 |
| Beik, A; Iranpour, M; Jafarinejad Farsangi, S; Joukar, S; Kordestani, Z; Najafipour, H; Rajabi, S | 1 |
| Abe, K; Aoki, M; Aoki-Shoi, N; Bo, Z; Go, T; Hiraishi, K; Hirano, K; Inoue, R; Ishikawa, K; Kishi, H; Kobayashi, S; Koga, K; Kurahara, LH; Toru, S; Yahiro, E; Yamamura, A; Yokomise, H; Zhang, Y | 1 |
| Kaisho, M; Okada, M; Otani, K; Sugiyama, A; Yamawaki, H | 1 |
| Cheng, TT; Chiu, MH; Fang, SY; Hsu, CH; Huang, CC; Lam, CF; Lin, MW; Roan, JN | 1 |
| Baranowska-Kuczko, M; Biernacki, M; Gromotowicz-Popławska, A; Kasacka, I; Kicman, A; Kozłowska, H; Krzyżewska, A; Malinowska, B; Sadowska, O | 1 |
| Bertoldi, AS; Coltro, GA; Gewehr, DM; Kubrusly, FB; Kubrusly, LF; Noronha, L; Preto, PC; Salgueiro, GR; Vieira, HI | 1 |
| Chen, S; Jiang, X; Li, L; Luo, J; Wang, J; Zhang, J; Zhou, L | 1 |
| Alda, MA; Balancin, M; Batah, SS; Capelozzi, VL; Cruvinel, HR; Fabro, AT; Machado-Rugolo, J; Perdoná Rodrigues da Silva, L; Rodrigues Lopes Roslindo Figueira, R; Silva, PL; Teodoro, WR; Velosa, AP | 1 |
| Deng, Y; Guo, SL; Li, JQ; Wang, F; Wang, Q; Wei, B; Xie, SS; Zhou, YC | 1 |
| Hu, J; Liu, S; Liu, W; Lu, S; Wang, Y; Wang, Z; Zeng, X | 1 |
| Chuang, KH; Gui, LX; Lin, DC; Lin, MJ; Sham, JSK; Wang, D; Yao, RH; Zheng, SY; Zhu, WJ; Zhu, ZL | 1 |
| Abdul-Salam, VB; Alvarez-Laviada, A; Dries, E; Faggian, G; Gorelik, J; Medvedev, R; Miragoli, M; Rossi, S; Sanchez-Alonso, JL; Schorn, T; Trayanova, N; Wojciak-Stothard, B | 1 |
| Akagi, S; Amioka, N; Ejiri, K; Fukami, K; Higashimoto, Y; Ito, H; Kondo, M; Matsubara, H; Miyoshi, T; Nakamura, K; Nakayama, R; Sakaguchi, M; Suastika, LOS; Takaya, Y; Yoshida, M | 1 |
| Ge, L; Jiang, W; Li, K; Luan, Y; Qi, T; Sun, C; Wang, J; Xin, Q; Zhang, S | 1 |
| Guo, L; Jiao, Y; Jin, H; Kim, SC; Li, X; Liu, J; Ma, Y; Shen, L; Zhao, R; Zhou, Z | 1 |
| Akagi, S; Berrebeh, N; Boucly, A; Chaouat, A; Cottin, V; Cumont, A; Fadel, E; Guignabert, C; Huertas, A; Humbert, M; Jaïs, X; Jutant, EM; Le Vely, B; Mercier, O; Montani, D; Phan, C; Savale, L; Sitbon, O; Tamura, Y; Thuillet, R; Tromeur, C; Tu, L | 1 |
| Ghofrani, HA; Grimminger, F; Kojonazarov, B; Novoyatleva, T; Schermuly, RT; Seeger, W; Veeroju, S; Weiss, A; Weissmann, N | 1 |
| Abrahamson, MD; Acosta, MF; Black, SM; Carver, M; Fineman, JR; Grijalva, CL; Klinger, C; Mansour, HM; Muralidhran, P; Tang, H | 1 |
| Akagi, S; Amioka, N; Ito, H; Kobayashi, K; Kondo, M; Miyoshi, T; Nakamura, K; Nakayama, R; Ohno, Y; Takaya, Y; Yoshida, M | 1 |
| Guo, J; Huo, S; Li, S; Lin, L; Luo, P; Lv, J; Peng, L; Shi, W; Wang, M; Yan, D; Zhang, C | 1 |
| Borges, RS; Duarte, GP; Gonzaga-Costa, K; Lahlou, S; Magalhães, PJC; Rebouça, CDSM; Rodrigues-Silva, MJ; Vasconcelos-Silva, AA | 1 |
| Cao, Y; Chen, F; Chu, C; Ding, J; Fulton, D; Hu, L; Huang, H; Li, K; Li, Y; Xu, P; Yu, Y | 1 |
| Dignam, JP; Hobbs, AJ; Kemp-Harper, BK; Scott, TE | 1 |
| Changcheng, L; Chen, W; Gaofeng, Z; Guoping, T; Luo, J; Min, Y; Minyan, Z; Ouyang, S; Yang, L | 1 |
| Abe, K; Hirano, K; Hirano, M; Hosokawa, K; Imakiire, S; Ishikawa, T; Takana-Ishikawa, M; Tsutsui, H; Watanabe, T; Yoshida, K | 1 |
| Awada, C; Bonnet, S; Boucherat, O; Bourgeois, A; Breuils-Bonnet, S; Grobs, Y; Lemay, SE; Nadeau, V; Orcholski, M; Paulin, R; Provencher, S; Romanet, C; Shimauchi, K; Toro, V; Tremblay, E | 1 |
| Matsumura, Y; Nagata, R; Nakagawa, K; Ohkita, M; Sawano, T; Sumi, Y; Tawa, M | 1 |
| Belló-Klein, A; Bonetto, JP; Campos-Carraro, C; Carregal, VM; Cechinel, LR; Corssac, GB; Grings, M; Leipnitz, G; Massensini, AR; Parmeggiani, B; Siqueira, I; Zimmer, A | 1 |
| Gao, G; Lian, G; Lin, T; Luo, L; Wang, H; Wu, J; Xie, L | 1 |
| Acharya, AP; Bertero, T; Chan, SY; Harvey, LD; Königshoff, M; Little, SR; Mitash, N; Pineda, R; Sun, W; Tai, YY; Tang, Y; Woodcock, CC | 1 |
| Antigny, F; Boët, A; Colsch, B; Delaporte, A; Fadel, E; Fenaille, F; Haddad, F; Hautbergue, T; Humbert, M; Junot, C; Lambert, M; Masson, B; Menager, JB; Mercier, O; Pavec, JL; Savale, L | 1 |
| Fujiwara, M; Hiraku, A; Horii, C; Kawade, A; Kobayashi, S; Kondo, R; Mori, S; Ohara, N; Suzuki, Y; Suzumura, S; Tsukamoto, K; Yamamura, A; Yamamura, H | 1 |
| Harper, R; Hodge, S; Maiolo, S; Reynolds, PN; Tran, HB; Zalewski, PD | 1 |
| Blackhurst, D; Cour, M; Diaba-Nuhoho, P; Hadebe, N; Lecour, S; Marais, D | 1 |
| Feng, T; Hu, Q; Li, J; Liu, B; Lu, Y; Su, Y; Sun, M; Wang, T; Xiao, R; Zhang, J; Zhu, L | 1 |
| Choi, SJ; Hong, YM; Kim, KC; Lee, H | 1 |
| Chen, Y; Deng, Y; Gao, X; Guo, S; Liu, C; Wei, B; Wu, W | 1 |
| Jasińska-Stroschein, M; Orszulak-Michalak, D; Oszajca, K; Ruchwa, J; Świtlik, W | 1 |
| Arase, H; Irahara, M; Kinoshita, H; Kitagawa, T; Kitaichi, T; Kurobe, H; Maeda, K; Nakayama, S; Sugano, M; Sugasawa, N; Yoshida, H | 1 |
| He, J; Li, T; Li, X; Liu, Y; Luo, H; Qi, Q; Yu, Z; Zhao, L | 1 |
| Aliotta, JM; Cheng, Y; Del Tatto, M; Dooner, MS; Goldberg, L; Klinger, JR; Liang, O; Papa, E; Pereira, M; Quesenberry, PJ; Ventetuolo, CE; Wen, S | 1 |
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| Chandrasekhar, B; Kadavil, EA; Oriowo, MA | 1 |
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| Cardoso, WV; Jones, JE; Loscalzo, J; Song, Y; Tuder, RM; Walker, JL; Weiss, N; Zhang, YY | 1 |
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| Bonartsev, AP; D'iakonov, KB; Medvedeva, NA; Postnikov, AB; Slavutskaia, AV | 1 |
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| Jin, D; Katayama, H; Kishi, K; Miyazaki, M; Muramatsu, M; Takai, S; Tamai, H | 1 |
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| Fletcher, BS; Liu, H; Liu, L; Visner, G | 1 |
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| Archer, SL; Bonnet, S; Hashimoto, K; McMurtry, MS; Michelakis, ED; Moudgil, R | 1 |
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| Liu, B; Liu, HM; Sun, XJ; Wang, XM; Wei, L; Yu, L; Zhou, TF | 1 |
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| Fukuchi, Y; Homma, N; Morio, Y; Muramatsu, M; Nagaoka, T; Sato, K; Takahashi, H; Yamamoto, A | 1 |
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| Draisma, HH; Henkens, IR; Maan, AC; Mouchaers, KT; Schalij, I; Schalij, MJ; Swenne, CA; van der Laarse, WJ; van der Wall, EE; Vliegen, HW; Vonk-Noordegraaf, A | 1 |
| Hongo, M; Ikeda, U; Kinoshita, O; Mawatari, E; Sakai, A; Takahashi, M; Terasawa, F; Yazaki, Y | 1 |
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| Hirose, T; Kido, M; Kurozumi, T; Shoyama, Y; Tanaka, K | 1 |
| Horwitz, LD; Kuriyama, T; Latham, LP; Sawada, A; Sugita, T; Wagner, WW; Watanabe, S | 1 |
| Suzuki, H; Twarog, BM | 1 |
| Widimský, J | 1 |
| Kay, JM; Keane, PM; Suyama, KL | 2 |
| Ashino, Y; Fujimura, S; Hoshikawa, Y; Maeda, S; Noda, M; Ono, S; Song, C; Tabata, T; Tanita, T; Ueda, S | 1 |
| Lin, BP; MacNicol, BJ; Tabrizchi, R | 1 |
| Eto, T; Kangawa, K; Kitamura, K; Matsuo, H; Sakata, J; Shimokubo, T | 1 |
| Honda, M; Ishinaga, Y; Kuramochi, T; Maeda, A; Mansoor, AM; Mitsui, Y; Saida, K; Takabatake, T | 1 |
| Goto, K; Miyauchi, T; Sakai, S; Sakurai, T; Sugishita, Y; Yamaguchi, I; Yorikane, R | 1 |
| Lai, YL; Zhou, KR | 1 |
| Kay, CS; O'Donnell, SR; Wanstall, JC | 2 |
| Ishikawa, H; Kasukawa, R; Miyata, M; Nishimaki, T; Sakuma, F; Yoshimura, A | 1 |
| Alvarez, TA; Choy, JS; Hacker, AD; Keller, PA; Madden, JA | 1 |
| Okada, K; Okada, M; Yamashita, C | 4 |
| Imai, S; Kanda, T; Murata, K; Suzuki, T; Takahashi, T | 1 |
| Kakusaka, I; Kaneko, N; Kiyatake, K; Kuriyama, T; Nakano, K; Suzuki, A | 2 |
| Hashimoto, H; Ishikawa, K; Ito, T; Mitani, S; Okumura, K; Toki, Y | 1 |
| Che, D; Wu, Y; Zhang, W | 1 |
| Arisaka, Y; Kato, S; Sato, S; Tomoike, H; Yuki, H | 1 |
| Inoue, M; Mori, C; Tanaka, O; Watanabe, K | 1 |
| Arend, WP; Bridges, J; Tuder, RM; Voelkel, NF | 1 |
| Hatanaka, K; Hayashi, T; Katayama, Y; Kitabatake, M; Kusagawa, M; Maruyama, K; Namikawa, S; Onoda, K; Yada, I; Yuasa, H | 1 |
| Heath, D; King, A; Smith, P | 1 |
| Hirokawa, E; Kotani, T; Kuwamura, M; Sakuma, S; Yamate, J | 1 |
| Hosoda, Y; Kanai, Y | 1 |
| Tuder, R; Voelkel, NF | 1 |
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| Ashino, Y; Fujimura, S; Hoshikawa, Y; Nishimura, T; Noda, M; Ono, S; Tabata, S; Tanita, T; Ueda, S | 1 |
| Kakusaka, I; Kaneko, N; Kasahara, Y; Kitada, M; Kiyatake, K; Kuriyama, T; Nakano, K; Qi, TM; Suzuki, A | 1 |
| Goto, K; Miyauchi, T; Sakai, S; Sakurai, T; Yorikane, R | 1 |
| Arcot, SS; Gillespie, MN; Lipke, DW; Olson, JW | 2 |
| Bhatti, T; Cathapermal, S; Chen, MF; Farhat, MY; Iqbal, A; Ramwell, PW | 1 |
| Ishibashi-Ueda, H; Kawaguchi, AT; Kawashima, Y; Kunieda, T; Murakami, T; Yagihara, T; Yanase, M | 1 |
| Aikawa, N; Hori, S; Hosoda, Y; Kanai, Y; Tanaka, T; Watanabe, K; Yasuoka, M | 1 |
| Morice, AH; Thompson, JS; Wanstall, JC | 1 |
| Hacker, AD | 2 |
| Harada, Y; Inoue, M; Mori, C; Tanaka, O; Watanabe, K | 1 |
| Kikuchi, K; Mori, C; Ohie, T; Watanabe, K | 1 |
| Goto, K; Miyauchi, T; Nishikibe, M; Okada, M; Sakai, S; Sakurai, T; Sugishita, Y; Yamaguchi, I; Yano, M; Yorikane, R | 1 |
| Pan, LC; Segall, HJ; Wilson, DW | 1 |
| Chao, J; Chao, L; Chen, LM; Chung, P; Simson, JA | 1 |
| Gewitz, MH; Mathew, R; Tun, H; Zeballos, GA | 1 |
| Emeis, JJ; Roth, RA; Schultze, AE | 1 |
| Ito, O; Kasukawa, R; Koike, H; Miyata, M; Nishimaki, T; Nishio, S; Sakuma, F; Sekine, H; Ueno, Y | 1 |
| Arcot, SS; Fagerland, JA; Gillespie, MN; Lipke, DW; Olson, JW | 1 |
| Imai, S; Kanda, T; Kobayashi, I; Murata, K; Suzuki, T; Takahashi, T | 1 |
| Cheng, D; Lei, S; Li, F; Li, T; Sun, B; Tan, Y; Yang, X; Yao, X; Zhang, J; Zhang, S | 1 |
| Arcot, SS; Aziz, SM; Fagerland, JA; Lipke, DL; Majesky, M | 1 |
| Bernstein, ML; Botney, MD; Cooper, JD; Mecham, RP; Patterson, GA; Tanaka, Y | 1 |
| Banner, W; Burch, GH; Hammond, EH; Jensen, LR; Pappas, J; Shaddy, RE | 1 |
| Diana, JN; Lai, YL; Thacker, AA | 1 |
| Archer, SL; Hampl, V; Hutsell, TC; Tristani-Firouzi, M | 1 |
| Clozel, JP; Clozel, M; Hess, P | 1 |
| Morita, K; Ogawa, Y; Tobise, K | 1 |
| Baradarian, R; Chiu, DT; Kim, ES; Smith, CR; Smith, ML; Smith, TJ; Yano, OJ | 1 |
| Inoue, M; Kanda, T; Kobayashi, I; Kodama, K; Nagai, R; Suzuki, T; Takahashi, T | 1 |
| Bittner, HB; Chen, EP; Davis, RD; Van Trigt, P | 5 |
| Kitabatake, M; Maruyama, J; Maruyama, K; Mitani, Y; Miyasaka, K; Yamauchi, T | 1 |
| Bittner, HB; Chen, EP; Craig, DM; Davis, RD; Van Trigt, P | 1 |
| Fujimura, S; Noda, M; Ono, S; Song, C; Suzuki, S; Tabata, T; Tanita, T | 1 |
| Dail, WG; Gonzales, RJ; Resta, TC; Sanders, TC; Walker, BR | 1 |
| Gewitz, MH; Gloster, ES; Mathew, R; Sundararajan, T; Thompson, CI; Zeballos, GA | 1 |
| Bittner, HB; Chen, EP; Craig, D; Davis, RD; Tull, F; Van Trigt, P | 1 |
| Nohara, H; Okada, K; Okada, M; Wakiyama, H; Yamagishi, H; Yamashita, C | 1 |
| Biswas, SS; Bittner, HB; Chen, EP; Davis, RD; Tull, F; Van Trigt, P | 1 |
| Lamé, MW; Morin, D; Reid, MJ; Segall, HJ; Wilson, DW | 1 |
| Chen, L; Chen, W; Lei, S; Li, F; Li, P; Sun, B; Tang, Y; Zhang, J; Zhang, S | 1 |
| Colice, GL; Du, H; Hill, N; Klinger, J; Lee, YJ; Leiter, JC; Ou, LC | 1 |
| Maruyama, K; Mitani, Y; Sakurai, M | 1 |
| Kakusaka, I; Kasahara, Y; Kitada, M; Kiyatake, K; Kuriyama, T; Ohmori, S; Sugito, K; Tatsumi, K; Yamagata, S | 1 |
| Baughn, J; Cassis, L; Fettinger, M; Gillespie, M; Lipke, D; Shenoy, U | 1 |
| Cernacek, P; Dupuis, J; Leung, TK; Prié, S; Ryan, JW | 1 |
| Bernstein, M; Botney, MD; Okada, K; Patterson, GA; Tanaka, Y; Zhang, W | 1 |
| Hill, NS; Klinger, JR; Pietras, L; Warburton, RR | 1 |
| Cui, S; Ding, W; Wang, B; Yang, B; Zhou, C | 1 |
| Frank, DU; Horstman, DJ; Rich, GF | 1 |
| Brown, L; Dagger, A; Miller, J; Sernia, C | 1 |
| Goto, A; Hara, K; Hazama, H; Hisada, T; Igarashi, K; Kimura, K; Nagata, T; Omata, M; Uehara, Y | 1 |
| Daemen, MJ; Smits, JF; van Suylen, RJ | 1 |
| Kasahara, Y; Kimura, H; Kuriyama, T; Kurosu, K; Matsushima, K; Mikata, A; Mukaida, N; Natsume, M; Sugito, K; Takiguchi, Y; Terai, M | 1 |
| Dupuis, J; Prié, S; Stewart, DJ | 1 |
| Inoue, M; Iwamoto, A; Kanda, T; Kobayashi, I; Nagai, R; Sakamaki, T; Sato, K; Sumino, H; Takahashi, T | 1 |
| Kasahara, Y; Kimura, H; Kuriyama, T; Kurosu, K; Matsushima, K; Mukaida, N; Sugito, K | 1 |
| Bernstein, ML; Botney, MD; Okada, K; Schuster, DP; Zhang, W | 1 |
| Inoue, M; Iwamoto, A; Kanda, T; Kobayashi, I; Nagai, R; Sumino, H; Takahashi, T | 1 |
| Horio, T; Kangawa, K; Matsuo, H; Nishikimi, T; Ohe, T; Takishita, S; Yoshihara, F; Yutani, C | 1 |
| Jin, X; Liu, K; Wang, H; Xing, J; Zhang, X | 1 |
| Chen, LC; Gordon, T; Nadziejko, C; Schlesinger, R | 2 |
| Adnot, S; Dreyfus, P; Eddahibi, S; Frelin, C; Levame, M; Partovian, C; Raffestin, B; Teiger, E | 1 |
| Madl, AK; Pinkerton, KE; Segall, HJ; Wilson, DW | 1 |
| Kasukawa, R; Miyata, M; Sakuma, F | 1 |
| Abman, SH; Bloch, KD; McMurtry, IF; Muramatsu, M; Rodman, DM; Stelzner, TJ; Tyler, RC | 1 |
| Frasch, HF; Marshall, BE; Marshall, C | 1 |
| Hill, LL; Pearl, RG | 1 |
| Akhter, SA; Bittner, HB; Chen, EP; Davis, RD; Koch, WJ; Van Trigt, P | 1 |
| Jin, X; Wang, HL; Xing, J; Zhang, DR; Zhang, XH | 1 |
| Al Tayeh, AU; Kanj, NA; Khoury, MY; Medawar, WA; Nassar, CF; Nasser, MG | 1 |
| Basaraba, RJ; Baybutt, RC; Swamidas, GP | 1 |
| Adachi, H; Kodama, K | 1 |
| Frank, DU; Horstman, DJ; McCall, DA; Rich, GF | 1 |
| Gout, B; Khandoudi, N; Le Dantec, C; Quiniou, MJ; Saïag, B | 1 |
| Campen, MJ; Costa, DL; Gardner, SY; Jackson, MC; Kodavanti, UP; Ledbetter, AD; Richards, JR; Watkinson, WP | 1 |
| Campbell, AI; Kuliszewski, MA; Stewart, DJ | 1 |
| Hori, M; Karaki, H; Nakazawa, H; Ozaki, H | 1 |
| Ambrosio, GB; Libera, LD; Sandri, M; Vescovo, G; Zennaro, R | 1 |
| Goto, K; Kobayashi, T; Miyauchi, T; Sakai, S; Ueno, M; Yamaguchi, I | 1 |
| Enomoto, M; Fukuta, Y; Iida, M; Ishii, K; Ishikawa, T; Iwata, H; Iwatsuki, Y; Kiyoshi, A; Nakayama, K | 1 |
| Brunner, F | 1 |
| Ito, M; Kasukawa, R; Miyata, M; Ohira, H; Sakuma, F; Sato, Y | 1 |
| Ito, M; Kasukawa, R; Miyata, M; Ohira, H; Sasajima, T; Sato, Y | 1 |
| Emdad, L; Honjo, H; Kodama, I; Magee, AI; Severs, NJ; Takagishi, Y; Uzzaman, M | 1 |
| Block, N; Brock, TA; Chen, SJ; Chen, YF; Dixon, RA; Munsch, CL; Sherwood, SJ; Tilton, RG; Wu, C | 1 |
| Cowan, KN; Heilbut, A; Humpl, T; Ito, S; Lam, C; Rabinovitch, M | 1 |
| Ito, K; Ito, KM; Nakai, M; Sato, M; Ushijima, K | 1 |
| Kaneda, Y; Kyotani, S; Miyatake, K; Morishita, R; Nagaya, N; Nakanishi, N; Nishikimi, T; Ogihara, T; Shimonishi, M; Tanabe, T; Uematsu, M; Yamagishi, M; Yokoyama, C | 1 |
| Irukayama-Tomobe, Y; Miyauchi, T; Sakai, S | 1 |
| Goto, K; Miyauchi, T; Sakai, S; Ueno, M; Yamaguchi, I | 1 |
| Goto, K; Kawano, S; Kobayashi, T; Kondo, H; Miyauchi, T; Sakai, S; Sato, R; Ueno, M; Yamaguchi, I | 1 |
| Benson, GV; Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG | 1 |
| Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG; Veve, I | 1 |
| Nakamura, M; Nakayama, K; Saito, M; Takeishi, K; Tanabe, Y; Ueno, A | 1 |
| Cernacek, P; Dupuis, J; Jasmin, JF; Lucas, M | 1 |
| Chen, MJ; Chiang, LY; Lai, YL | 1 |
| Hatanaka, K; Hayashi, T; Katayama, Y; Kusagawa, M; Namikawa, S; Yada, I; Yuasa, H | 1 |
| Katzman, NJ; Lai, YL | 1 |
| Cai, R; Cheng, X; Liu, Z | 1 |
| Angelini, A; Battista Ambrosio, G; Dalla Libera, L; Ravara, B; Rossini, K; Sandri, M; Thiene, G; Vescovo, G | 1 |
| Tanino, Y | 1 |
| Nakanishi, N; Sato, N | 1 |
| Hori, M; Karaki, H; Murata, T; Nakazawa, H; Ozaki, H | 1 |
| Billiar, TR; Ho, C; Kanno, S; Lee, PC; Wu, YJ | 1 |
| Abe, T; Muraki, S; Nagashima, M; Seki, S; Tohse, N; Yabu, H; Yamada, Y | 1 |
| Campbell, AI; Sandhu, R; Stewart, DJ; Zhao, Y | 1 |
| Dong, X; Wang, HL; Xing, J; Zhang, XH | 1 |
| Adnot, S; Dortho, MP; Eddahibi, S; Frisdal, E; Gest, V; Harf, A; Lafuma, C; Lepetit, H; Levame, M; Vieillard-Baron, A | 1 |
| Ben, X; Li, F; Liang, Y; Qin, Y; Shen, J; Zhou, A | 1 |
| Brunner, F; Haleen, S; Wölkart, G | 1 |
| Brodde, OE; Dhein, S; Giessler, C; Heinroth-Hoffmann, I; Leineweber, K; Seyfarth, T | 1 |
| Li, ZC; Mei, QB; Song, JC; Zhang, FQ; Zhao, DH | 1 |
| Chang, D; Gunaydin, S; Hagino, I; Imai, Y; Seo, K; Shinoka, T; Takanashi, Y | 1 |
| Kaneko, N; Kato, S; Kishiro, I; Machida, M; Sugimura, H; Suzuki, H | 1 |
| Johnson, WD; Lalich, JL; Raczniak, TJ; Shumaker, RC | 1 |
| Hashimoto, H; Ito, T; Kondo, J; Okumura, K; Shimizu, K; Toki, Y; Yoshino, M | 1 |
| Che, DY; Li, WY | 1 |
| Ono, S; Voelkel, NF | 2 |
| Onodera, S | 1 |
| Ishibashi-Ueda, H; Kanosue, K; Kawaguchi, AT; Kawashima, Y; Matsuda, H; Mizuta, T; Shirakura, R | 1 |
| Lu, ZS | 1 |
| Miyata, M; Takeshita, M; Yoshida, H; Yoshida, S | 1 |
| Che, DY; Li, WY; Wang, HY | 1 |
| Cassis, LA; Fitz, R; Gillespie, MN; Painter, DJ; Rippetoe, PE; Soltis, EE | 1 |
| Kawaguchi, AT; Kawashima, Y; Matsuda, H; Mizuta, T; Nakahara, K; Shirakura, R; Tanaka, H | 2 |
| Honda, M; Ishikawa, S; Ishinaga, Y; Morioka, S; Moriyama, K; Tanaka, K; Yano, S | 1 |
| Hayakawa, H; Hirata, Y; Kangawa, K; Kojima, M; Matsuo, H; Matsuoka, H; Sugimoto, T; Suzuki, E | 1 |
| Heath, D | 1 |
| O'Donnell, SR; Wanstall, JC | 2 |
| Dodo, H; Keeley, FW; McCready, L; Rabinovitch, M; Todorovich-Hunter, L; Ye, C | 1 |
| Ceconi, C; Ferrari, R; Harris, P; Heath, D; O'Neill, D; Rodella, A; Smith, P | 1 |
| Hashimoto, H; Ito, T; Okumura, K; Satake, T; Yamada, Y | 1 |
| Caslin, A; Heath, D; Smith, P | 1 |
| Gillespie, MN; Lai, YL; Olson, JW | 1 |
| Reindel, JF; Roth, RA | 1 |
| Sun, BT | 2 |
| Rabinovitch, M; Ye, CL | 1 |
| Ogawa, Y; Takenaka, T; Tobise, K | 1 |
| Archer, SL; Cowan, N; DeMaster, EG; Nelson, DP; Rist, K; Weir, EK | 1 |
| Ganey, PE; Reindel, JF; Roth, RA; Slocombe, RF; Wagner, JG | 1 |
| Cohen, DA; Gillespie, MN; Goldblum, SE; Hennig, B; McClain, CJ; Olson, JW | 1 |
| Ilkiw, R; Maruyama, K; Rabinovitch, M; Shin, J; Todorovich-Hunter, L | 1 |
| Kanisawa, M; Kato, T; Kitamura, H | 1 |
| Fujita, A; Kakusaka, I; Kaneko, N; Kiyatake, K; Kuriyama, T; Nakano, K; Okada, O; Sugita, T; Suzuki, A; Watanabe, S | 1 |
| Dunston, SK; Pan, LC; Segall, HJ; Wilson, DW | 1 |
| Gillespie, MN; Olson, JW; Orlinska, U | 2 |
| Gillespie, MN; Haven, CA; Maley, BE; Olson, JW; Orlinska, U; Rippetoe, PE; Shiao, RT | 1 |
| Gerdes, AM; McDonough, KH; Summer, WR; Werchan, PM | 1 |
| Gagnon, J; Hill, NS; Jederlinic, P | 1 |
| Altura, BM; Altura, BT; Mathew, R | 1 |
| Ito, T; Kira, Y; Murata, M; Okabe, F; Sekine, I; Takahashi, M | 1 |
| Baron, DA; Currie, MG; Kurtz, DT; Oehlenschlager, WF | 1 |
| Roth, RA; Wagner, JG; White, SM | 1 |
| Ganey, PE; Roth, RA | 6 |
| Altiere, RJ; Gillespie, MN; O'Connor, WN; Olson, JW; Reinsel, CN | 1 |
| Cottrill, CM; Gillespie, MN; Johnson, GL | 1 |
| Akimoto, K; Hayakawa, K; Kangawa, K; Matsuo, H; Miyata, A | 1 |
| Roth, RA; White, SM | 1 |
| Altura, BM; Altura, BT; Gloster, ES; Mathew, R | 1 |
| Lappe, RW; Lee, KC | 1 |
| Molteni, A; Solliday, N; Ts'ao, C; Ward, W | 1 |
| Czer, GT; Konopka, R; Marsh, J; Moser, KM | 1 |
| Carvalho, AC; Langleben, D; Reid, LM | 1 |
| Hoffman, EA; Liu, YH; Ritman, EL | 1 |
| Guzowski, DE; Salgado, ED | 1 |
| Kataoka, R; Tobise, K | 1 |
| Johnson, DJ; Keeley, FW; Rabinovitch, M; Ranger, P; Todorovich-Hunter, L | 1 |
| Cohen, DA; Gillespie, MN; Goldblum, SE; McClain, CJ | 1 |
| Banner, W; Huxtable, RJ; Shubat, PJ | 1 |
| Rabinovitch, M; Rosenberg, HC | 1 |
| Coflesky, JT; Evans, JN; Jones, RC; Langleben, D; Reid, LM; Szarek, JL | 1 |
| Langleben, D; Reid, LM | 1 |
| Ganey, PE; Roth, RA; Sprugel, KH; Wagner, JG; White, SM | 1 |
| Bruner, LH; Johnson, KJ; Roth, RA; Till, GO | 1 |
| Bruner, LH; Bull, RW; Roth, RA | 1 |
| Henson, PM; Mathias, MM; Morganroth, ML; Murphy, RC; Reeves, JT; Remigio, LK; Stenmark, KR; Voelkel, NF | 1 |
| Altiere, RJ; Frederick, WB; Gillespie, MN; Kimmel, EC; Olson, JW | 1 |
| Kuriyama, T; Sawada, A; Sugita, T; Watanabe, S | 1 |
| Hayashi, Y; Hiroshima, K; Kuriyama, T; Sawada, A; Shen, SY; Sugita, T; Watanabe, S | 1 |
| Kakusaka, I; Kohchi, F; Kuriyama, T; Naitoh, T; Ogata, T; Okada, O; Sawada, A; Sugita, T; Watanabe, S; Yamagishi, F | 1 |
| Hilliker, KS; Roth, RA | 1 |
15 review(s) available for monocrotaline and Hypertension, Pulmonary
| Article | Year |
|---|---|
[Pulmonary artery denervation in pulmonary hypertension: physiological and clinical aspects].
Topics: Animals; Denervation; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Vascular Resistance | 2021 |
A review of genetically-driven rodent models of pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Artery; Rodentia | 2022 |
Animal models of pulmonary hypertension: Getting to the heart of the problem.
Topics: Animals; Disease Models, Animal; Heart Failure; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Ventricular Dysfunction, Right; Ventricular Function, Right | 2022 |
A New Stem Cell Biology: Transplantation and Baseline, Cell Cycle and Exosomes.
Topics: Animals; Antigens, Differentiation; Bone Marrow Cells; Cell Cycle; Cell Lineage; Cell Separation; Cell Survival; Cell-Derived Microparticles; Clone Cells; Erythroid Cells; Exosomes; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Hypertension, Pulmonary; Mesenchymal Stem Cells; Mice; Models, Biological; Monocrotaline; Myeloid Cells; Radiation Chimera | 2018 |
Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Mice; Monocrotaline; Rats | 2015 |
Polyamine regulatory pathways as pharmacologic targets in pulmonary arterial hypertension.
Topics: Animals; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Monocrotaline; Polyamines | 2010 |
Novel approaches to treat experimental pulmonary arterial hypertension: a review.
Topics: Animals; Antihypertensive Agents; Cell- and Tissue-Based Therapy; Disease Models, Animal; Genetic Therapy; Hypertension, Pulmonary; Monocrotaline | 2010 |
The monocrotaline model of pulmonary hypertension in perspective.
Topics: Acute Lung Injury; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Humans; Hypertension, Pulmonary; Lung; Monocrotaline; Myocarditis | 2012 |
Matrix metalloproteinases and their inhibitors in pulmonary hypertension.
Topics: Airway Remodeling; Animals; Capillary Permeability; Humans; Hypertension, Pulmonary; Lung; Matrix Metalloproteinases; Mice; Monocrotaline; Rats; Tissue Inhibitor of Metalloproteinases | 2012 |
How valid are animal models to evaluate treatments for pulmonary hypertension?
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Ductus Arteriosus; Embolism; Humans; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Poisons | 2006 |
[Animal models of pulmonary arterial hypertension].
Topics: Animals; Animals, Genetically Modified; Arteriovenous Shunt, Surgical; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline | 2007 |
[Monocrotaline-induced pulmonary hypertension in animals].
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline; Rats; Rats, Sprague-Dawley | 2001 |
[Drug induced pulmonary hypertension].
Topics: Aminorex; Appetite Depressants; Diagnosis, Differential; Female; Humans; Hypertension, Pulmonary; Monocrotaline | 2001 |
[Pulmonary vasoconstrictor responses].
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Calcium; Dogs; Histamine; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Monocrotaline; Potassium Channels; Pulmonary Circulation; Pulmonary Embolism; Rats; Serotonin; Vasoconstriction | 1992 |
Lung vascular injury from monocrotaline pyrrole, a putative hepatic metabolite.
Topics: Animals; Biotransformation; Endothelium, Vascular; Hypertension, Pulmonary; Liver; Lung; Monocrotaline; Pyrrolizidine Alkaloids | 1991 |
1 trial(s) available for monocrotaline and Hypertension, Pulmonary
| Article | Year |
|---|---|
Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.
Topics: Adult; Aged; Animals; Benzamides; Cell Division; Dichloroacetic Acid; Disease Models, Animal; Drug Monitoring; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Gene Expression Profiling; Glycolysis; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Indoles; Lung; Male; Middle Aged; Monocrotaline; Piperazines; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sunitinib; Young Adult | 2013 |
1073 other study(ies) available for monocrotaline and Hypertension, Pulmonary
| Article | Year |
|---|---|
Characterization of a New Monocrotaline Rat Model to Study Chronic Neonatal Pulmonary Hypertension.
Topics: Animals; Animals, Newborn; Chronic Disease; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Rats | 2021 |
Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Hemoglobins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Inositol Phosphates; Male; Monocrotaline; Myocardial Contraction; Rats; Rats, Wistar; Treatment Outcome; Ventricular Dysfunction, Right; Ventricular Function, Right | 2021 |
Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension.
Topics: Animals; Cation Transport Proteins; Cell Movement; Cell Proliferation; CREB-Binding Protein; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Smooth Muscle; Protein Phosphatase 2; Pulmonary Artery; Rats; Transcriptional Activation; Tumor Hypoxia; Zinc | 2021 |
Effects of Copaiba Oil in Peripheral Markers of Oxidative Stress in a Model of Cor Pulmonale in Rats.
Topics: Animals; Hypertension, Pulmonary; Male; Monocrotaline; Oxidative Stress; Pulmonary Heart Disease; Rats; Rats, Wistar | 2021 |
Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension.
Topics: Animals; Apoptosis; Arterial Pressure; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor CHOP; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right; X-Box Binding Protein 1 | 2021 |
Intermittent Fasting Enhances Right Ventricular Function in Preclinical Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fasting; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right; Ventricular Function, Right | 2021 |
Pioglitazone restores phosphorylation of downregulated caveolin-1 in right ventricle of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Caveolin 1; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Phosphorylation; Pioglitazone; Rats; Rats, Wistar | 2022 |
Role of oxidative stress versus lipids in monocrotaline-induced pulmonary hypertension and right heart failure.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Catalase; Echocardiography; Glutathione Peroxidase; Heart; Heart Failure; Hemodynamics; Hypertension, Pulmonary; Lipid Peroxidation; Lovastatin; Lung; Monocrotaline; Myocardium; Organ Size; Oxidative Stress; Probucol; Rats; Superoxide Dismutase; Ventricular Dysfunction, Right | 2021 |
Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension.
Topics: Animals; Drug Delivery Systems; Flavanones; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Tumor Suppressor Protein p53 | 2022 |
The therapeutic effect and mechanism of Rapamycin combined with HO-3867 on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline; Piperidones; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sirolimus | 2022 |
Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension.
Topics: Apoptosis; DNA Damage; Endoplasmic Reticulum Stress; Humans; Hypertension, Pulmonary; Monocrotaline; Transcription Factor CHOP; X-Box Binding Protein 1 | 2022 |
Protective effects of Dapagliflozin on the vulnerability of ventricular arrhythmia in rats with pulmonary artery hypertension induced by monocrotaline.
Topics: Animals; Arrhythmias, Cardiac; Benzhydryl Compounds; Disease Models, Animal; Glucosides; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2022 |
Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Disease Models, Animal; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Pulmonary Artery; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, G-Protein-Coupled; Receptors, Neurotransmitter; Systole; Vasoconstriction; Ventricular Dysfunction, Right; Ventricular Function, Right | 2022 |
Flavopiridol Mitigates the Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Targeting Cyclin-Dependent Kinase 9.
Topics: Animals; Cyclin-Dependent Kinase 9; Humans; Hypertension, Pulmonary; Monocrotaline; Myeloid Cell Leukemia Sequence 1 Protein; Pulmonary Artery; Rats; RNA Polymerase II; Survivin | 2023 |
DL0805-1, a novel Rho-kinase inhibitor, attenuates lung injury and vasculopathy in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bosentan; Disease Models, Animal; Hypertension, Pulmonary; Indazoles; Male; Monocrotaline; Nitriles; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents | 2022 |
Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Phosphatidylinositol 3-Kinases; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Vascular Endothelial Growth Factor A; Ventricular Remodeling | 2022 |
Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.
Topics: Animals; Arrhythmias, Cardiac; Dantrolene; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Prognosis; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Ventricular Dysfunction, Right; Ventricular Function, Right | 2022 |
Puerarin-V prevents the progression of hypoxia- and monocrotaline-induced pulmonary hypertension in rodent models.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Isoflavones; Mice; Monocrotaline; Phosphatidylinositol 3-Kinases; Pulmonary Artery; Rats; Rodentia; Vascular Remodeling | 2022 |
High magnesium mitigates the vasoconstriction mediated by different types of calcium influx from monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Calcium; Endothelial Cells; Hypertension, Pulmonary; Magnesium; Mice; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction | 2022 |
Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation.
Topics: Animals; Bacterial Toxins; Cells, Cultured; Cyclohexylamines; Down-Regulation; Endothelial Cells; Ferroptosis; Heart Ventricles; Hemodynamics; HMGB1 Protein; Hypertension, Pulmonary; Inflammasomes; Inflammation; Lung; Macrophages; Male; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Phenylenediamines; Rats, Sprague-Dawley; Toll-Like Receptor 4; Up-Regulation | 2022 |
Shufeiya Recipe Improves Monocrotaline-Induced Pulmonary Hypertension in Rats by Regulating SIRT3/FOXO3a and Its Downstream Signaling Pathways.
Topics: Animals; Blood Pressure; Cyclooxygenase 1; Cyclooxygenase 2; Drugs, Chinese Herbal; Forkhead Box Protein O3; Hypertension, Pulmonary; Male; Membrane Proteins; Monocrotaline; Nitric Oxide Synthase; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Sirtuin 3; Superoxide Dismutase | 2022 |
Lung damage created by high tidal volume ventilation in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Hypertension, Pulmonary; Lung Diseases; Male; Monocrotaline; Random Allocation; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Tidal Volume | 2022 |
Efficacy of interatrial shunt devices: an opening window to acute pulmonary hypertensive crisis and chronic pulmonary arterial hypertension.
Topics: Animals; Dogs; Hemodynamics; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Arterial Hypertension | 2022 |
The zinc transporter ZIP12 regulates monocrotaline-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/ERK signaling pathways.
Topics: Animals; Carrier Proteins; Cation Transport Proteins; Cell Movement; Cell Proliferation; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Signal Transduction | 2022 |
Tetramethylpyrazine Improves Monocrotaline-Induced Pulmonary Hypertension through the ROS/iNOS/PKG-1 Axis.
Topics: Animals; Hypertension, Pulmonary; Monocrotaline; Nitric Oxide Synthase Type II; Protein Kinases; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2022 |
Caspase-8 Promotes Pulmonary Hypertension by Activating Macrophage-Associated Inflammation and IL-1β (Interleukin 1β) Production.
Topics: Animals; Caspase 1; Caspase 8; Hypertension, Pulmonary; Hypoxia; Inflammasomes; Inflammation; Interleukin-1beta; Macrophages; Mice; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Rats | 2022 |
CRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Clustered Regularly Interspaced Short Palindromic Repeats; Fibrosis; Humans; Hypertension, Pulmonary; Lung; Mice; Monocrotaline; Point Mutation; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Tadalafil | 2022 |
Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Glucosides; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Sildenafil Citrate; Vascular Remodeling | 2022 |
Contractile Behavior of Right Atrial Myocardium of Healthy Rats and Rats with the Experimental Model of Pulmonary Hypertension.
Topics: Animals; Hypertension, Pulmonary; Models, Theoretical; Monocrotaline; Myocardial Contraction; Myocardium; Rats; Rats, Wistar | 2022 |
Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension.
Topics: Animals; Fluvoxamine; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right; Ventricular Remodeling | 2022 |
Targeting Apoptosis Signal-Regulating Kinase-1 (ASK-1) As a Biomarker of Monocrotaline-Induced Pulmonary Hypertension following Administration of Antiretroviral Medications in Rat Model.
Topics: Animals; Anti-Retroviral Agents; Apoptosis; Biomarkers; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Ritonavir; Zidovudine | 2022 |
Mesenchymal Stem Cell-derived Nanovesicles as a Credible Agent for Therapy of Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Extracellular Vesicles; Hypertension, Pulmonary; Mesenchymal Stem Cells; MicroRNAs; Monocrotaline; Rats | 2022 |
Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-κB pathways.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Glucosides; Hypertension, Pulmonary; MAP Kinase Kinase Kinases; Monocrotaline; Monoterpenes; NF-kappa B; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2022 |
The Levels of TNF-
Topics: Animals; Blood Coagulation; Disease Models, Animal; Drug Carriers; Hypertension, Pulmonary; Monocrotaline; Nanoparticles; Pulmonary Artery; Rats; Sildenafil Citrate; Thromboplastin; Tumor Necrosis Factor-alpha | 2022 |
A potential model of systemic sclerosis with pulmonary hypertension induced by monocrotaline plus bleomycin.
Topics: Animals; Bleomycin; Hypertension, Pulmonary; Lung; Monocrotaline; Rabbits; Scleroderma, Systemic | 2022 |
Cannabidiol Improves Antioxidant Capacity and Reduces Inflammation in the Lungs of Rats with Monocrotaline-Induced Pulmonary Hypertension.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cannabidiol; Hypertension, Pulmonary; Inflammation; Lung; Monocrotaline; NF-kappa B; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2022 |
[Tanshinone IIA alleviates monocrotaline-induced pulmonary hypertension in rats through the PI3K/Akt-eNOS signaling pathway].
Topics: Abietanes; Animals; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2022 |
TPN171H alleviates pulmonary hypertension via inhibiting inflammation in hypoxia and monocrotaline-induced rats.
Topics: Animals; Anti-Inflammatory Agents; Cathepsin B; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Inflammasomes; Inflammation; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Vascular Remodeling | 2022 |
Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Imatinib Mesylate; MicroRNAs; Monocrotaline; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2022 |
Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension.
Topics: Animals; Atrial Natriuretic Factor; Cytokine Receptor gp130; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fibrosis; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammasomes; Macrophage Activation; Macrophages; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Pulmonary Arterial Hypertension; Rats; Ventricular Dysfunction, Right | 2022 |
Role of miR-21-5p/FilGAP axis in estradiol alleviating the progression of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Estradiol; Estrogen Receptor beta; GTPase-Activating Proteins; Humans; Hypertension, Pulmonary; Male; MicroRNAs; Monocrotaline; Rats | 2022 |
Apela gene therapy alleviates pulmonary hypertension in rats.
Topics: Animals; Apelin Receptors; Genetic Therapy; Hypertension, Pulmonary; Kruppel-Like Transcription Factors; Monocrotaline; Peptide Hormones; Pulmonary Artery; Rats | 2022 |
Artemisinin and Its Derivate Alleviate Pulmonary Hypertension and Vasoconstriction in Rodent Models.
Topics: Animals; Artemisinins; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Myocytes, Smooth Muscle; NADPH Oxidases; Nitric Oxide; Rats; Reactive Oxygen Species; Rodentia; Signal Transduction; Vascular Remodeling; Vasoconstriction | 2022 |
Transgelin exacerbates pulmonary artery smooth muscle cell dysfunction in shunt-related pulmonary arterial hypertension.
Topics: Animals; Cell Proliferation; Humans; Hypertension, Pulmonary; Microfilament Proteins; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Transforming Growth Factor beta1 | 2022 |
Prostaglandin E1 reduces apoptosis and improves the homing of mesenchymal stem cells in pulmonary arterial hypertension by regulating hypoxia-inducible factor 1 alpha.
Topics: Alprostadil; Animals; Apoptosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Vascular Endothelial Growth Factor A | 2022 |
Astragaloside IV in Hypoxic Pulmonary Hypertension: an In Vivo and In Vitro Experiments.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Rats; Saponins; Tumor Necrosis Factor-alpha | 2022 |
Silencing TUFM Inhibits Development of Monocrotaline-Induced Pulmonary Hypertension by Regulating Mitochondrial Autophagy via AMPK/mTOR Signal Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; bcl-2-Associated X Protein; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases | 2022 |
Apolipoprotein A5 ameliorates MCT induced pulmonary hypertension by inhibiting ER stress in a GRP78 dependent mechanism.
Topics: Animals; Apolipoprotein A-V; Cell Proliferation; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley | 2022 |
Chitinase 3 like 1 contributes to the development of pulmonary vascular remodeling in pulmonary hypertension.
Topics: Animals; Bleomycin; Chitinase-3-Like Protein 1; Humans; Hypertension, Pulmonary; Mice; Mice, Knockout; Mice, Transgenic; Monocrotaline; Vascular Remodeling | 2022 |
Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline.
Topics: Animals; Autophagy; Cell Proliferation; Endothelial Cells; Geranyltranstransferase; Hypertension, Pulmonary; Mevalonic Acid; Monocrotaline; Monomeric GTP-Binding Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases | 2022 |
Mineralocorticoid Receptor Antagonism by Finerenone Attenuates Established Pulmonary Hypertension in Rats.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Mice; Mineralocorticoid Receptor Antagonists; Monocrotaline; Naphthyridines; Pulmonary Artery; Rats; Receptors, Mineralocorticoid; Vascular Remodeling | 2022 |
HNRNPA2B1: RNA-Binding Protein That Orchestrates Smooth Muscle Cell Phenotype in Pulmonary Arterial Hypertension.
Topics: Animals; Cell Proliferation; Familial Primary Pulmonary Hypertension; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Hypertension, Pulmonary; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; RNA; RNA-Binding Proteins | 2022 |
Pyrroloquinoline quinone (PQQ) improves pulmonary hypertension by regulating mitochondrial and metabolic functions.
Topics: Animals; Endothelial Cells; Humans; Hypertension, Pulmonary; Inflammation; Monocrotaline; PQQ Cofactor; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2022 |
Intra-Airway Gene Delivery for Pulmonary Hypertension in Rodent Models.
Topics: Animals; Disease Models, Animal; Genetic Therapy; Heart Failure; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Rats; Rodentia | 2022 |
Attenuating effect of magnesium on pulmonary arterial calcification in rodent models of pulmonary hypertension.
Topics: Animals; Calcium; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Magnesium; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; RNA, Messenger; Rodentia; Transcription Factors | 2022 |
Resistance Exercise Training Mitigates Left Ventricular Dysfunctions in Pulmonary Artery Hypertension Model.
Topics: Animals; Collagen Type I; Collagen Type III; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Physical Conditioning, Animal; Pulmonary Artery; Rats; Rats, Wistar; Resistance Training; Ventricular Dysfunction, Left | 2022 |
Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Arginine Vasopressin; Cysteine; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hepatocyte Growth Factor; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Malondialdehyde; Melatonin; Monocrotaline; NF-E2-Related Factor 2; Proto-Oncogene Proteins; Pulmonary Arterial Hypertension; Rats; RNA, Small Interfering; Ventricular Remodeling | 2022 |
Activation of Autophagy Induces Monocrotaline-Induced Pulmonary Arterial Hypertension by FOXM1-Mediated FAK Phosphorylation.
Topics: Actins; Animals; Autophagy; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Forkhead Box Protein M1; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Ki-67 Antigen; Monocrotaline; Phosphorylation; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2022 |
Allopurinol treatment reduced vascular remodeling and improved vascular functions in monocrotaline-induced pulmonary hypertensive rats.
Topics: Allopurinol; Animals; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Uric Acid; Vascular Remodeling | 2022 |
Saluisn-β contributes to endothelial dysfunction in monocrotaline-induced pulmonary arterial hypertensive rats.
Topics: Acetylcholine; Animals; Antioxidants; Disease Models, Animal; Hypertension; Hypertension, Pulmonary; Immunoglobulin G; Monocrotaline; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Superoxides | 2022 |
Exercise training counteracts the cardiac metabolic remodelling induced by experimental pulmonary arterial hypertension.
Topics: Amino Acids; Animals; Disease Models, Animal; Fatty Acids; Glucose; Glucose Transporter Type 4; Hypertension, Pulmonary; Lactate Dehydrogenases; Male; Monocrotaline; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2022 |
[Pulmonary Vascular Remodeling Characteristics of Pulmonary Arterial Hypertension Mouse Model Induced by Left Pneumonectomy and Jugular Vein Injection of Monocrotaline Pyrrole].
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Jugular Veins; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Neointima; Pneumonectomy; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling | 2022 |
Upregulation of miR-335-5p Contributes to Right Ventricular Remodeling via Calumenin in Pulmonary Arterial Hypertension.
Topics: Angiotensin II; Animals; Antagomirs; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Mice; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Up-Regulation; Ventricular Remodeling | 2022 |
Cardioprotective Effect of Resistance Exercise on Left Ventricular Remodeling Associated with Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Resistance Training; Vascular Remodeling; Ventricular Remodeling | 2022 |
Impact of ATP synthase/coupling factor 6 in hypoxic pulmonary arterial hypertension: An experimental rat model.
Topics: Adenosine Triphosphate; Animals; Hypertension, Pulmonary; Hypoxia; Male; Mitochondrial Proton-Translocating ATPases; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Wistar; RNA, Messenger | 2022 |
Differential effect of basal vitamin D status in monocrotaline induced pulmonary arterial hypertension in normal and vitamin D deficient rats: Possible involvement of eNOS/TGF-β/α-SMA signaling pathways.
Topics: Animals; Calcitriol; Human Umbilical Vein Endothelial Cells; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor beta; Vitamin D; Vitamin D Deficiency; Vitamins | 2023 |
Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.
Topics: Animals; Cellular Senescence; Endothelial Cells; Familial Primary Pulmonary Hypertension; Forkhead Transcription Factors; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Senotherapeutics | 2023 |
PRDX6-mediated pulmonary artery endothelial cell ferroptosis contributes to monocrotaline-induced pulmonary hypertension.
Topics: Animals; Endothelial Cells; Ferroptosis; HMGB1 Protein; Hypertension, Pulmonary; Inflammasomes; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Peroxiredoxin VI; Pulmonary Artery; Rats; Reactive Oxygen Species; Toll-Like Receptor 4; Vascular Remodeling | 2023 |
Cannabidiol inhibits lung proliferation in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Cannabidiol; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Lung; Monocrotaline; Procollagen; Rats; Transforming Growth Factor beta1 | 2023 |
Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3β signaling pathway and alleviates pulmonary arterial hypertension in rats.
Topics: Animals; Cell Transdifferentiation; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Glycogen Synthase Kinase 3 beta; Hypertension, Pulmonary; Male; Monocrotaline; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Signal Transduction | 2023 |
Ormeloxifene, a selective estrogen receptor modulator, protects against pulmonary hypertension.
Topics: Animals; Estradiol; Estrogen Receptor alpha; Female; Humans; Hypertension, Pulmonary; Hypoxia; Inflammation; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators | 2023 |
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Echocardiography; Heart Ventricles; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Ventricular Dysfunction, Right; Ventricular Function, Right | 2023 |
Ranolazine exerts atrial antiarrhythmic effects in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Heart Atria; Hypertension, Pulmonary; Monocrotaline; Ranolazine; Rats; Rats, Wistar | 2023 |
A modified Fangji Huangqi decoction ameliorates pulmonary artery hypertension via phosphatidylinositide 3-kinases/protein kinase B-mediated regulation of proliferation and apoptosis of smooth muscle cells in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Proliferation; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA; Vascular Remodeling | 2023 |
Thoracic Spinal Cord Neuroinflammation as a Novel Therapeutic Target in Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Minocycline; Monocrotaline; Neuroinflammatory Diseases; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Spinal Cord | 2023 |
Jiedu Quyu Decoction mitigates monocrotaline-induced right-sided heart failure associated with pulmonary artery hypertension by inhibiting NLRP3 inflammasome in rats.
Topics: Animals; Biomarkers; Heart Failure; Hypertension, Pulmonary; Inflammasomes; Interleukin-18; Interleukin-1beta; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2023 |
Nobiletin attenuates monocrotaline-induced pulmonary arterial hypertension through PI3K/Akt/STAT3 pathway.
Topics: Animals; Cytokines; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2023 |
Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor β pathway in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Cannabidiol; Fibronectins; Fibrosis; Heart Failure; Hypertension, Pulmonary; Monocrotaline; Rats; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2023 |
Maresin-1 protects against pulmonary arterial hypertension by improving mitochondrial homeostasis through ALXR/HSP90α axis.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Heat-Shock Proteins; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Vascular Remodeling | 2023 |
Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Heart Atria; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats | 2023 |
Skeletal muscle blood flow during exercise is reduced in a rat model of pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Lung; Monocrotaline; Muscle, Skeletal; Pulmonary Artery; Rats | 2023 |
HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo.
Topics: Animals; Cell Proliferation; Cells, Cultured; HMGB1 Protein; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Protein Serine-Threonine Kinases; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2023 |
Exploring the involvement of TASK-1 in the control of isolated rat right atrium function from healthy animals and an experimental model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Atrial Fibrillation; Heart Atria; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Models, Theoretical; Monocrotaline; Rats; Rats, Wistar | 2023 |
CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Cells, Cultured; Hypertension, Pulmonary; Integrin beta Chains; Male; MicroRNAs; Monocrotaline; Myoblasts, Smooth Muscle; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; RNA, Circular; TOR Serine-Threonine Kinases; Up-Regulation; Vascular Remodeling | 2023 |
Copaiba oil improves pulmonary nitric oxide bioavailability in monocrotaline-treated rats.
Topics: Animals; Antioxidants; Biological Availability; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Nitric Oxide; Oils, Volatile; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Wistar | 2023 |
[Angiotensin-(1-7) improves endothelium-dependent vasodilation in rats with monocrotaline-induced pulmonary arterial hypertension].
Topics: Acetylcholine; Animals; Endothelial Cells; Endothelium; Humans; Hypertension, Pulmonary; Monocrotaline; Nitroprusside; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasodilation | 2023 |
[Panax notoginseng saponins improve monocrotaline-induced pulmonary arterial hypertension in rats by inhibiting ADAM10/Notch3 signaling pathway].
Topics: Animals; Caspase 3; Collagen; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Panax notoginseng; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Notch3; RNA, Messenger; Saline Solution; Saponins; Signal Transduction | 2023 |
Isolated Left Atrium Morphofunctional Study of an Experimental Pulmonary Hypertension Model in Rats.
Topics: Animals; Arrhythmias, Cardiac; Heart Atria; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2023 |
Targeting IL-11 system as a treatment of pulmonary arterial hypertension.
Topics: Animals; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Interleukin-11; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; RNA, Small Interfering | 2023 |
Canagliflozin ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting pulmonary arterial smooth muscle cell proliferation.
Topics: Animals; Canagliflozin; Cell Proliferation; Glucose; Humans; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling | 2023 |
CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension.
Topics: Animals; CD146 Antigen; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Feedback, Physiological; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Knockout; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Pulmonary Artery; Rats; Severity of Illness Index; Up-Regulation; Vascular Remodeling | 2019 |
Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension.
Topics: 4-Butyrolactone; Animals; Animals, Newborn; Cells, Cultured; Fatty Acid Synthase, Type I; Gene Expression Regulation, Enzymologic; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Ventricular Remodeling | 2019 |
Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation.
Topics: Animals; Cells, Cultured; Cysteine; Cytokines; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Humans; Hydrogen Sulfide; Hypertension, Pulmonary; I-kappa B Kinase; Inflammation; Inflammation Mediators; Intercellular Adhesion Molecule-1; Male; Monocrotaline; NF-kappa B; Pulmonary Artery; Rats, Wistar; Signal Transduction | 2019 |
TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension.
Topics: Adventitia; Animals; Cell Proliferation; Cells, Cultured; Fibroblasts; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; TRPV Cation Channels; Up-Regulation | 2020 |
Involvement of miR-200b-PKCα signalling in pulmonary hypertension in cor pulmonale model.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Protein Kinase C-alpha; Pulmonary Heart Disease; Signal Transduction | 2020 |
Investigational new drug enabling angiotensin oral-delivery studies to attenuate pulmonary hypertension.
Topics: Animals; Drugs, Investigational; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2020 |
Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats.
Topics: Animals; Chemokines; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth; Pulmonary Artery; Rats; Rats, Wistar; Receptors, CCR; Receptors, Chemokine; Signal Transduction; Up-Regulation | 2020 |
Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Pharmaceutical Preparations; Pulmonary Artery; Pyrazines; Rats; Rats, Sprague-Dawley | 2020 |
Pulmonary Hypertension Remodels the Genomic Fabrics of Major Functional Pathways.
Topics: Animals; Genomics; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction | 2020 |
Aquaporin-2 expression in the kidney and urine is elevated in rats with monocrotaline-induced pulmonary heart disease.
Topics: Animals; Aquaporin 2; Arginine Vasopressin; Biomarkers; Disease Models, Animal; Humans; Hypertension, Pulmonary; Kidney; Male; Monocrotaline; Pulmonary Heart Disease; Rats; Renal Elimination | 2020 |
Protein tyrosine phosphatase L1 represses endothelial-mesenchymal transition by inhibiting IL-1β/NF-κB/Snail signaling.
Topics: Animals; Cell Transdifferentiation; Down-Regulation; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Hypertension, Pulmonary; Interleukin-1beta; Male; Monocrotaline; NF-kappa B p50 Subunit; NF-KappaB Inhibitor alpha; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Rats, Sprague-Dawley; Signal Transduction; Snail Family Transcription Factors | 2020 |
Chrysin Alleviates Monocrotaline-Induced Pulmonary Hypertension in Rats Through Regulation of Intracellular Calcium Homeostasis in Pulmonary Arterial Smooth Muscle Cells.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Calcium Signaling; Disease Models, Animal; Flavonoids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats, Sprague-Dawley; TRPC Cation Channels; Vascular Remodeling; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2020 |
Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats.
Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Gene Silencing; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Prohibitins; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Repressor Proteins; RNA, Small Interfering | 2020 |
Early progression of pulmonary hypertension in the monocrotaline model in males is associated with increased lung permeability.
Topics: Animals; Blood Pressure; Capillary Permeability; Disease Models, Animal; Disease Progression; Endothelial Cells; Female; Heme; Hemolysis; HSP27 Heat-Shock Proteins; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Rats, Sprague-Dawley; Sex Characteristics; Tight Junctions | 2020 |
Pterostilbene improves cardiac function in a rat model of right heart failure through modulation of calcium handling proteins and oxidative stress.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antioxidants; Calcium; Echocardiography; Glutathione; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Lipid Peroxidation; Male; Monocrotaline; Oxidative Stress; Rats; Rats, Wistar; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Stilbenes; Stroke Volume | 2020 |
Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.
Topics: Animals; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferase 1; Epigenesis, Genetic; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mitochondria, Heart; Mitochondrial Dynamics; Monocrotaline; Myofibroblasts; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2020 |
Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction.
Topics: Animals; Cell Movement; Cell Proliferation; Crown Ethers; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Hypertension, Pulmonary; In Vitro Techniques; MAP Kinase Signaling System; Microfilament Proteins; Monocrotaline; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteopontin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Quinazolines; Rats; Signal Transduction; Vascular Remodeling; Ventricular Function, Right; Ventricular Pressure; Vimentin | 2020 |
MicroRNA-483 amelioration of experimental pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; MicroRNAs; Monocrotaline; Rats | 2020 |
Novel angiogenesis strategy to ameliorate pulmonary hypertension.
Topics: Animals; Hepatocyte Growth Factor; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Neovascularization, Physiologic; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2021 |
Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice.
Topics: Animals; Female; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Monocrotaline; Obesity; Rats; Rats, Zucker; Sex Characteristics; Vascular Remodeling; Ventricular Function, Right | 2020 |
Changes in heart morphometric parameters over the course of a monocrotaline-induced pulmonary arterial hypertension rat model.
Topics: Animals; Heart Ventricles; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2020 |
Protective effect of nicotinamide and L-arginine against monocrotaline-induced pulmonary hypertension in rats: gender dependence.
Topics: Animals; Arginine; Female; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Niacinamide; Protective Agents; Pulmonary Artery; Rats; Rats, Wistar | 2020 |
Perillyle alcohol and Quercetin ameliorate monocrotaline-induced pulmonary artery hypertension in rats through PARP1-mediated miR-204 down-regulation and its downstream pathway.
Topics: Animals; Disease Models, Animal; Down-Regulation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia-Inducible Factor 1, alpha Subunit; Male; MicroRNAs; Monocrotaline; Monoterpenes; NFATC Transcription Factors; Poly (ADP-Ribose) Polymerase-1; Pulmonary Artery; Quercetin; Rats; Rats, Wistar | 2020 |
Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.
Topics: Animals; Cell Proliferation; Eicosapentaenoic Acid; Endothelial Cells; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-6; Male; Mesoderm; Monocrotaline; Myocardial Contraction; Myocytes, Smooth Muscle; Phosphorylation; Proto-Oncogene Proteins c-fyn; Pulmonary Artery; Rats, Sprague-Dawley; src-Family Kinases; STAT3 Transcription Factor; Survival Analysis; Transforming Growth Factor beta2; Vasodilation; Ventricular Remodeling | 2020 |
Decreased Expression of Canstatin in Rat Model of Monocrotaline-Induced Pulmonary Arterial Hypertension: Protective Effect of Canstatin on Right Ventricular Remodeling.
Topics: Animals; Body Weight; Cardiotonic Agents; Collagen Type IV; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Kidney; Lung; Male; Monocrotaline; Organ Size; Peptide Fragments; Rats; Rats, Wistar; Recombinant Proteins; Ventricular Remodeling | 2020 |
Transplantation of viable mitochondria improves right ventricular performance and pulmonary artery remodeling in rats with pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Vascular Remodeling; Ventricular Remodeling | 2022 |
Cannabidiol Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats.
Topics: Animals; Blood Pressure; Cannabidiol; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Ventricular Function, Right | 2020 |
Plexiform Lesions in an Experimental Model of Monocrotalin-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2020 |
Sympathetic innervation of canine pulmonary artery and morphometric and functional analysis in dehydromonocrotaline-induced models after pulmonary artery denervation.
Topics: Animals; Disease Models, Animal; Dogs; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Artery; Sympathectomy; Sympathetic Nervous System; Vascular Resistance | 2020 |
In situ Evidence of Collagen V and Interleukin-6/Interleukin-17 Activation in Vascular Remodeling of Experimental Pulmonary Hypertension.
Topics: Animals; Collagen; Disease Models, Animal; Hypertension, Pulmonary; Interleukin-17; Interleukin-6; Male; Monocrotaline; Rats; Rats, Wistar; Vascular Remodeling | 2020 |
Interferon regulatory factor 7 inhibits rat vascular smooth muscle cell proliferation and inflammation in monocrotaline-induced pulmonary hypertension.
Topics: Activating Transcription Factor 3; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Cyclin D1; Dependovirus; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Inflammation; Interferon Regulatory Factor-7; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Proliferating Cell Nuclear Antigen; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Signal Transduction; Survivin; Up-Regulation; Vascular Remodeling | 2021 |
Sacubitril/valsartan treatment relieved the progression of established pulmonary hypertension in rat model and its mechanism.
Topics: Aminobutyrates; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Body Weight; Disease Models, Animal; Disease Progression; Drug Combinations; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Tetrazoles; Valsartan | 2021 |
Magnesium Supplementation Attenuates Pulmonary Hypertension via Regulation of Magnesium Transporters.
Topics: Animals; Apoptosis; Cation Transport Proteins; Cell Movement; Cell Proliferation; Down-Regulation; Hypertension, Pulmonary; Hypoxia; Magnesium; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Up-Regulation; Vascular Remodeling | 2021 |
Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension.
Topics: Animals; Calcium; Calcium Signaling; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2021 |
Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Receptor for Advanced Glycation End Products | 2021 |
Mesenchymal Stromal Cell-derived Exosomes Attenuate Experimental Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Exosomes; Hypertension, Pulmonary; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Arterial Hypertension; Rats | 2021 |
Astragaloside IV blocks monocrotaline‑induced pulmonary arterial hypertension by improving inflammation and pulmonary artery remodeling.
Topics: Animals; Hypertension, Pulmonary; Inflammation; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes; Vascular Remodeling | 2021 |
Serum and pulmonary uric acid in pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Uric Acid | 2021 |
Therapeutic Potential of Regorafenib-A Multikinase Inhibitor in Pulmonary Hypertension.
Topics: Animals; Cell Division; Cell Movement; Drug Evaluation, Preclinical; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hypertension, Pulmonary; Hypoxia; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylurea Compounds; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2021 |
Comparison of l-Carnitine and l-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultures, and in vivo MCT-Rat model of PH.
Topics: Administration, Inhalation; Aerosols; Animals; Carnitine; Cell Culture Techniques; Dry Powder Inhalers; Hypertension, Pulmonary; Lung; Monocrotaline; Particle Size; Powders; Rats; Rats, Sprague-Dawley | 2020 |
Efficacy of shear wave elastography for evaluating right ventricular myocardial fibrosis in monocrotaline-induced pulmonary hypertension rats.
Topics: Animals; Elasticity Imaging Techniques; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Monocrotaline; Myocardium; Rats | 2021 |
S-Nitroso-L-Cysteine Ameliorated Pulmonary Hypertension in the MCT-Induced Rats through Anti-ROS and Anti-Inflammatory Pathways.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Movement; Collagen; Cysteine; Endoplasmic Reticulum Stress; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; MAP Kinase Signaling System; Matrix Metalloproteinases; Mitophagy; Monocrotaline; Muscle Contraction; Muscle, Smooth; Oxidative Stress; Phosphorylation; Rats, Sprague-Dawley; Reactive Oxygen Species; S-Nitrosothiols; STAT3 Transcription Factor; Vascular Remodeling; Wound Healing | 2021 |
Soluble guanylate cyclase stimulator, trans-4-methoxy-β-nitrostyrene, has a beneficial effect in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterioles; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Signal Transduction; Soluble Guanylyl Cyclase; Styrenes; Vascular Remodeling; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Bmi-1 alleviates adventitial fibroblast senescence by eliminating ROS in pulmonary hypertension.
Topics: Adventitia; Animals; Cell Line; Cell Proliferation; Cellular Senescence; Disease Models, Animal; Fibroblasts; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Monocrotaline; Polycomb Repressive Complex 1; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2021 |
Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline via the TGF‑β1/p38 MAPK/CREB signaling pathway.
Topics: Animals; Anthocyanins; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Monocrotaline; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Rats; Transforming Growth Factor beta1; Vascular Remodeling | 2021 |
Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats.
Topics: Animals; Antirheumatic Agents; Chloroquine; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 9; Vascular Remodeling | 2021 |
Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension.
Topics: Animals; Antipsychotic Agents; Cardiovascular Agents; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Repositioning; Female; Forkhead Box Protein O3; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Survivin; Trifluoperazine | 2021 |
Preventive effects of nitrate-rich beetroot juice supplementation on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Beta vulgaris; Blood Pressure; Dietary Supplements; Fruit and Vegetable Juices; Hypertension, Pulmonary; Male; Monocrotaline; Nitrates; Rats; Rats, Sprague-Dawley | 2021 |
Pulmonary arterial hypertension induces the release of circulating extracellular vesicles with oxidative content and alters redox and mitochondrial homeostasis in the brains of rats.
Topics: Animals; Brain; Disease Models, Animal; Extracellular Vesicles; Homeostasis; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Oxidation-Reduction; Oxidative Stress; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2021 |
Influence of atorvastatin on metabolic pattern of rats with pulmonary hypertension.
Topics: Animals; Arterial Pressure; Atorvastatin; Disease Models, Animal; Fatty Acids; Glycolysis; Humans; Hypertension, Pulmonary; Lung; Male; Metabolomics; Monocrotaline; Oxidation-Reduction; Pulmonary Artery; Rats; Vascular Remodeling | 2021 |
Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension.
Topics: Administration, Inhalation; Animals; Benzeneacetamides; Cells, Cultured; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Combinations; Drug Compounding; Enzyme Inhibitors; Glutaminase; Hemodynamics; Humans; Hypertension, Pulmonary; Intracellular Signaling Peptides and Proteins; Lung; Male; Mechanotransduction, Cellular; Monocrotaline; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Sprague-Dawley; Thiadiazoles; Time Factors; Vascular Remodeling; Ventricular Function, Right; Verteporfin; YAP-Signaling Proteins | 2021 |
Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure.
Topics: Animals; Chronic Disease; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Rats; Rats, Wistar; Ventricular Remodeling | 2021 |
Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats.
Topics: Adult; Age Factors; Animals; Calcium Channels; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Monocrotaline; Pulmonary Artery; Rats, Sprague-Dawley; Receptors, Calcium-Sensing | 2021 |
Dysregulated zinc and sphingosine-1-phosphate signaling in pulmonary hypertension: Potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Cation Transport Proteins; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Lung; Lysophospholipids; Male; Microvessels; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Vascular Remodeling; Zinc | 2021 |
Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension.
Topics: Animals; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Wine | 2021 |
Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Genetic Predisposition to Disease; Hypertension, Pulmonary; Male; Monocrotaline; Nuclear Magnetic Resonance, Biomolecular; Parathyroid Hormone; Phenotype; Protein Binding; Pulmonary Artery; Rats, Sprague-Dawley; Rats, Transgenic; Receptors, Calcium-Sensing; RNA Interference; Signal Transduction; Transfection | 2017 |
Optimal Dose and Timing of Umbilical Stem Cells Treatment in Pulmonary Arterial Hypertensive Rats.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors | 2017 |
Altered mTOR and Beclin-1 mediated autophagic activation during right ventricular remodeling in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Autophagy; Beclin-1; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases; Ventricular Dysfunction, Right; Ventricular Remodeling | 2017 |
Treatment with platelet-derived growth factor (PDGF) and rock inhibitors is related to declined nerve growth factor (NGF) signaling in an experimental model of rat pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Imatinib Mesylate; Male; Monocrotaline; Nerve Growth Factor; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; RNA, Messenger; Signal Transduction | 2017 |
Effects of Transplanted Human Cord Blood-Mononuclear Cells on Pulmonary Hypertension in Immunodeficient Mice and Their Distribution.
Topics: Animals; Cord Blood Stem Cell Transplantation; Disease Models, Animal; Fetal Blood; Heterografts; Humans; Hypertension, Pulmonary; Lung; Mice; Mice, Inbred BALB C; Mice, Nude; Monocrotaline; Pulmonary Artery | 2017 |
Galectin-3 mediates the pulmonary arterial hypertension-induced right ventricular remodeling through interacting with NADPH oxidase 4.
Topics: Adult; Animals; Biomarkers; Collagen Type III; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Galectin 3; Gene Knockdown Techniques; Heart Ventricles; Humans; Hypertension, Pulmonary; Male; Middle Aged; Monocrotaline; Myocardium; Myofibroblasts; NADPH Oxidase 4; Oxidative Stress; Primary Cell Culture; Rats; Transforming Growth Factor beta1; Up-Regulation; Ventricular Remodeling; Young Adult | 2017 |
Bone Marrow Endothelial Progenitor Cells Are the Cellular Mediators of Pulmonary Hypertension in the Murine Monocrotaline Injury Model.
Topics: Animals; Cells, Cultured; Endothelial Progenitor Cells; Extracellular Vesicles; Hypertension, Pulmonary; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Vascular Endothelial Growth Factor Receptor-2 | 2017 |
Expression profile of matricellular proteins in hypertrophied right ventricle of monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; CCN Intercellular Signaling Proteins; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Transcriptome | 2017 |
Astragalus Polysaccharides Attenuate Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Astragalus Plant; Cytokines; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type III; Polysaccharides; Rats, Sprague-Dawley; Signal Transduction; Vascular Resistance | 2017 |
The protective effects of PCPA against monocrotaline-induced pulmonary arterial hypertension are mediated through the downregulation of NFAT-1 and NF-κB.
Topics: Animals; Disease Models, Animal; Fenclonine; Hypertension, Pulmonary; Male; Monocrotaline; NFATC Transcription Factors; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Tryptophan Hydroxylase | 2017 |
RP5063, a novel, multimodal, serotonin receptor modulator, prevents monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Cytokines; Dose-Response Relationship, Drug; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Receptors, Serotonin | 2017 |
Valsartan attenuates pulmonary hypertension via suppression of mitogen activated protein kinase signaling and matrix metalloproteinase expression in rodents.
Topics: Animals; Blood Pressure; Cell Proliferation; Extracellular Matrix; Fibrosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; MAP Kinase Signaling System; Matrix Metalloproteinases; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Monocrotaline; Phosphorylation; Rats, Sprague-Dawley; Systole; Transforming Growth Factor beta1; Valsartan; Vascular Remodeling | 2017 |
Preventive treatment with atorvastatin ameliorates endothelial dysfunction of small pulmonary arteries in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Atorvastatin; Endothelium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Pulmonary Wedge Pressure; Random Allocation; Rats; Rats, Sprague-Dawley; Vasodilation | 2017 |
Crotalaria (Monocrotaline) Pulmonary Hypertension: The Fiftieth Anniversary.
Topics: Anniversaries and Special Events; Crotalaria; Humans; Hypertension, Pulmonary; Monocrotaline | 2017 |
Osthole attenuates pulmonary arterial hypertension in monocrotaline‑treated rats.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Coumarins; Disease Models, Animal; Hypertension, Pulmonary; Lung; Male; Monocrotaline; NF-kappa B; Organ Size; Pulmonary Artery; Rats, Sprague-Dawley | 2017 |
Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cardiomegaly; Catalase; Echocardiography; Glutathione Peroxidase; Heart Ventricles; Hypertension, Pulmonary; Liver; Lung; Male; Monocrotaline; NADPH Oxidases; Oxidative Stress; Rats, Wistar; Stilbenes; Superoxide Dismutase; Systole; Ventricular Function | 2017 |
Visceral adipose tissue-derived serine protease inhibitor prevents the development of monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Apoptosis; Disease Models, Animal; Fibrosis; Hypertension, Pulmonary; Intra-Abdominal Fat; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Wistar; Reactive Oxygen Species; Serine Proteinase Inhibitors; Signal Transduction | 2017 |
Preserved right ventricular integrity in a new telemetric rat model of severe pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Pulmonary Artery; Rats, Sprague-Dawley; Ventricular Function, Right | 2017 |
Cysteine-rich 61 (Cyr61) upregulated in pulmonary arterial hypertension promotes the proliferation of pulmonary artery smooth muscle cells.
Topics: Adult; Aged; Animals; Cell Proliferation; Cysteine-Rich Protein 61; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Signal Transduction | 2017 |
Mechanisms of N‑acetylcysteine in reducing monocrotaline‑induced pulmonary hypertension in rats: Inhibiting the expression of Nox1 in pulmonary vascular smooth muscle cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Proliferation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidase 1; Pulmonary Artery; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Vascular Remodeling | 2017 |
Diethylcarbamazine: A potential treatment drug for pulmonary hypertension?
Topics: Actins; Animals; Apoptosis; Apoptosis Regulatory Proteins; Bone Morphogenetic Protein Receptors, Type II; Collagen Type I; Diethylcarbamazine; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mice, Inbred C57BL; Monocrotaline; Pulmonary Artery; Ventricular Function, Left | 2017 |
Effects of ovariectomy on antioxidant defence systems in the right ventricle of female rats with pulmonary arterial hypertension induced by monocrotaline.
Topics: Adaptation, Physiological; Animals; Antioxidants; Female; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Ovariectomy; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rats, Wistar; Ventricular Remodeling | 2018 |
The Long Noncoding RNA LnRPT Is Regulated by PDGF-BB and Modulates the Proliferation of Pulmonary Artery Smooth Muscle Cells.
Topics: Animals; Becaplermin; Cell Proliferation; Cells, Cultured; Cyclin A2; Down-Regulation; Hypertension, Pulmonary; Indazoles; Jagged-1 Protein; Male; Monocrotaline; Myocytes, Smooth Muscle; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Notch3; RNA Interference; RNA, Long Noncoding; RNA, Small Interfering; Sulfonamides | 2018 |
Protective effects of aloperin on monocroline-induced pulmonary hypertension via regulation of Rho A/Rho kinsase pathway in rats.
Topics: Animals; bcl-2-Associated X Protein; Cardiomegaly; Cyclin-Dependent Kinase Inhibitor p27; Electrocardiography; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Piperidines; Proliferating Cell Nuclear Antigen; Protective Agents; Pulmonary Artery; Quinolizidines; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Vascular Remodeling | 2017 |
Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension.
Topics: Adipose Tissue; Animals; Antigens, CD; Cell Proliferation; Collagen; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Interleukin-6; Lung; Macrophages; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Microtubule-Associated Proteins; Monocrotaline; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Smad1 Protein; Survivin; Vascular Endothelial Growth Factor A; Vascular Remodeling | 2017 |
Expression of key enzymes in the mevalonate pathway are altered in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hemodynamics; Hypertension, Pulmonary; Metabolic Networks and Pathways; Mevalonic Acid; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; rhoA GTP-Binding Protein | 2017 |
Clinical and histopathological relationship of sildenafil and bosentan treatments in rats with monocrotaline induced pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Rats; Rats, Wistar; Sildenafil Citrate; Sulfonamides | 2017 |
Dihydromyricetin prevents monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Flavonols; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Vascular Remodeling | 2017 |
Docosahexaenoic acid inhibits monocrotaline-induced pulmonary hypertension via attenuating endoplasmic reticulum stress and inflammation.
Topics: Animals; Cells, Cultured; Docosahexaenoic Acids; Endoplasmic Reticulum Stress; Hypertension, Pulmonary; Inflammation; Macrophages; Male; Monocrotaline; Rats; Rats, Sprague-Dawley | 2018 |
Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Indoles; Male; Monocrotaline; Nestin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pulmonary Artery; Pyrroles; Rats, Wistar; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting vascular remodeling in rats.
Topics: Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flavanones; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Male; MAP Kinase Signaling System; Monocrotaline; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2018 |
Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.
Topics: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; Endothelium, Vascular; Enzyme Activators; Humans; Hypertension, Pulmonary; Imidazoles; Leucine; Lung; Male; Monocrotaline; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peptidyl-Dipeptidase A; Phosphorylation; Pulmonary Artery; Pyrans; Rats; Rats, Sprague-Dawley; Signal Transduction; Specific Pathogen-Free Organisms; Spiro Compounds; Xanthenes | 2017 |
Heart rate reduction improves biventricular function and interactions in experimental pulmonary hypertension.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Carvedilol; Disease Models, Animal; Drug Therapy, Combination; Heart Rate; Hypertension, Pulmonary; Ivabradine; Male; Monocrotaline; Rats, Sprague-Dawley; Recovery of Function; Time Factors; Ventricular Function, Left; Ventricular Function, Right | 2018 |
PPARγ Alleviates Right Ventricular Failure Secondary to Pulmonary Arterial Hypertension in Rats.
Topics: Animals; Apoptosis; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells; Heart Failure; Hypertension, Pulmonary; Lipid Metabolism; Male; Monocrotaline; Myocytes, Cardiac; PPAR gamma; Random Allocation; Rats, Sprague-Dawley | 2017 |
Fifty Years of Monocrotaline-Induced Pulmonary Hypertension: What Has It Meant to the Field?
Topics: Anniversaries and Special Events; Crotalaria; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery | 2017 |
Exendin-4 improves cardiovascular function and survival in flow-induced pulmonary hypertension.
Topics: Actins; Animals; Antihypertensive Agents; Aorta; Arterial Pressure; Arteriovenous Shunt, Surgical; Cyclic AMP; Disease Models, Animal; Exenatide; Hypertension, Pulmonary; Interleukin-1beta; Male; Monocrotaline; Myosin Heavy Chains; Myosin Type II; Phosphorylation; Pulmonary Artery; Pulmonary Circulation; Rats, Sprague-Dawley; Regional Blood Flow; Vascular Remodeling; Vena Cava, Inferior; Ventricular Function, Right | 2018 |
Protection against monocrotaline-induced pulmonary arterial hypertension and caveolin-1 downregulation by fluvastatin in rats.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Antihypertensive Agents; Caveolin 1; Drug Administration Schedule; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Indoles; Injections, Subcutaneous; Male; Monocrotaline; Rats; Rats, Wistar; Signal Transduction | 2018 |
Fluorescent Imaging Analysis for Distribution of Fluorescent Dye Labeled- or Encapsulated-Liposome in Monocrotaline-Induced Pulmonary Hypertension Model Rat.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Drug Liberation; Fluorescent Dyes; Hypertension, Pulmonary; Liposomes; Lung; Male; Monocrotaline; Optical Imaging; Particle Size; Permeability; Polyethylene Glycols; Pulmonary Surfactant-Associated Protein D; Rats; Rats, Wistar; Reactive Oxygen Species; Surface Properties | 2018 |
Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Cell Proliferation; Cells, Cultured; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Male; Mevalonic Acid; Monocrotaline; Polyisoprenyl Phosphates; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Signal Transduction; Simvastatin; Vascular Remodeling | 2018 |
Urantide improves the structure and function of right ventricle as determined by echocardiography in monocrotaline-induced pulmonary hypertension rat model.
Topics: Animals; Disease Models, Animal; Echocardiography, Doppler; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Peptide Fragments; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Urotensins; Ventricular Function, Right | 2019 |
Low dose monocrotaline causes a selective pulmonary vascular lesion in male and female pneumonectomized rats.
Topics: Acute Lung Injury; Animals; Apoptosis; Endothelial Cells; Female; Hypertension, Pulmonary; Lung; Lung Diseases; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats | 2018 |
Stage‑dependent changes of β2‑adrenergic receptor signaling in right ventricular remodeling in monocrotaline‑induced pulmonary arterial hypertension.
Topics: Animals; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Rats, Wistar; Receptors, Adrenergic, beta-2; Signal Transduction; Ventricular Dysfunction, Right; Ventricular Remodeling | 2018 |
Lumped-parameter models of the pulmonary vasculature during the progression of pulmonary arterial hypertension.
Topics: Animals; Hemodynamics; Hypertension, Pulmonary; Male; Models, Cardiovascular; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2018 |
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Topics: Animals; Apoptosis; Calcinosis; Calcium Channels; Cell Differentiation; Gene Expression Regulation; Granzymes; Hypertension, Pulmonary; Hypoxia; Killer Cells, Natural; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteoblasts; Primary Cell Culture; Pulmonary Artery; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction; T-Lymphocytes, Cytotoxic | 2018 |
Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension by down-regulating HSP70.
Topics: Animals; Grape Seed Extract; HSP70 Heat-Shock Proteins; Hypertension, Pulmonary; Male; Monocrotaline; Proanthocyanidins; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling; Vitis | 2018 |
EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension.
Topics: Animals; Epithelial-Mesenchymal Transition; Fibrosis; Heart Ventricles; Human Umbilical Vein Endothelial Cells; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E, EP4 Subtype; Tetrazoles; Transforming Growth Factor beta | 2018 |
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Topics: Animals; Becaplermin; Cell Movement; Cell Proliferation; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; HEK293 Cells; Histone Deacetylases; Humans; Hypertension, Pulmonary; Male; MicroRNAs; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Pulmonary Artery; Rats, Sprague-Dawley; Repressor Proteins; Signal Transduction; Vascular Remodeling | 2018 |
Calcium mishandling impairs contraction in right ventricular hypertrophy prior to overt heart failure.
Topics: Animals; Calcium; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoproterenol; Male; Monocrotaline; Myocardial Contraction; Rats; Rats, Wistar; Sarcoplasmic Reticulum | 2018 |
Fasudil and DETA NONOate, Loaded in a Peptide-Modified Liposomal Carrier, Slow PAH Progression upon Pulmonary Delivery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chemistry, Pharmaceutical; Disease Progression; Hypertension, Pulmonary; Liposomes; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Nitric Oxide Donors; Peptides; Polyamines; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents | 2018 |
Cardioprotective effect of cerium oxide nanoparticles in monocrotaline rat model of pulmonary hypertension: A possible implication of endothelin-1.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cerium; Electrocardiography; Endothelin-1; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nanoparticles; Nucleosides; Organ Size; Oxidative Stress; Poisons; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Triazoles | 2018 |
Cystamine slows but not inverses the progression of monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterioles; Cystamine; Heart Septum; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pressure; Protein Glutamine gamma Glutamyltransferase 2; Pulmonary Artery; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Survival Analysis; Transglutaminases; Vascular Remodeling | 2018 |
Trapidil improves hemodynamic, echocardiographic and redox state parameters of right ventricle in monocrotaline-induced pulmonary arterial hypertension model.
Topics: Animals; Blood Pressure; Calcium; Cardiac Catheterization; Cardiomegaly; Disease Models, Animal; Echocardiography; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Oxidation-Reduction; Rats, Wistar; Trapidil | 2018 |
3,7-Bis(2-hydroxyethyl)icaritin, a potent inhibitor of phosphodiesterase-5, prevents monocrotaline-induced pulmonary arterial hypertension via NO/cGMP activation in rats.
Topics: Animals; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelin-1; Flavonoids; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2018 |
A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Bone Morphogenetic Protein Receptors, Type II; Cell Movement; Cell Proliferation; Cell Shape; Disease Models, Animal; Endothelial Cells; Exosomes; Humans; Hypertension, Pulmonary; Lentivirus; Lung; Male; Monocrotaline; Mutation; Myocytes, Smooth Muscle; Protein Transport; Pulmonary Artery; Rats, Sprague-Dawley; Tumor Protein, Translationally-Controlled 1; Vascular Remodeling | 2018 |
Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats.
Topics: Adenosine A2 Receptor Agonists; Animals; Benzamides; Drug Synergism; Hydrazones; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Wistar; Sildenafil Citrate; Vasodilator Agents | 2018 |
Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung.
Topics: Animals; Antimycin A; Electron Transport Complex III; Female; Glycolysis; Humans; Hypertension, Pulmonary; Lung; Male; Mitochondria; Monocrotaline; Rats; Rats, Sprague-Dawley; Vasoconstriction; Ventricular Dysfunction, Right | 2018 |
MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3 signaling pathways.
Topics: Animals; Apoptosis; Cells, Cultured; Down-Regulation; Gene Expression Regulation; Hypertension, Pulmonary; Interleukin-6; Male; MicroRNAs; Monocrotaline; Pulmonary Artery; Rats; Signal Transduction; STAT3 Transcription Factor; Transforming Growth Factor beta; Vascular Remodeling | 2018 |
Stimulation of nitric oxide-sensitive soluble guanylate cyclase in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Blood Pressure; Bronchodilator Agents; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Soluble Guanylyl Cyclase | 2018 |
Bucindolol attenuates the vascular remodeling of pulmonary arteries by modulating the expression of the endothelin-1 A receptor in rats with pulmonary arterial hypertension.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Echocardiography; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type III; Oxidative Stress; Propanolamines; Pulmonary Artery; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Vascular Remodeling | 2018 |
Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension.
Topics: Animals; Cytokines; Disease Models, Animal; Hypertension, Pulmonary; Male; Microglia; Monocrotaline; Paraventricular Hypothalamic Nucleus; Pulmonary Wedge Pressure; Rats; Rats, Sprague-Dawley | 2018 |
Metabolic reprogramming of the urea cycle pathway in experimental pulmonary arterial hypertension rats induced by monocrotaline.
Topics: Animals; Hypertension, Pulmonary; Male; Metabolomics; Monocrotaline; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction; Urea | 2018 |
Beneficial effects of fenofibrate in pulmonary hypertension in rats.
Topics: Animals; Female; Fenofibrate; Hypertension, Pulmonary; Inflammation; Monocrotaline; Oxidative Stress; Rats; Rats, Wistar | 2018 |
Dipeptidyl peptidase IV (DPP-4) inhibition alleviates pulmonary arterial remodeling in experimental pulmonary hypertension.
Topics: Animals; Becaplermin; Bleomycin; Cell Movement; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Hypertension, Pulmonary; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Myocytes, Smooth Muscle; PTEN Phosphohydrolase; Random Allocation; Rats, Wistar; Sitagliptin Phosphate; Tunica Intima; Vascular Remodeling; Ventricular Remodeling | 2018 |
Cardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Estrogens; Exercise Tolerance; Female; Hypertension, Pulmonary; Monocrotaline; Muscle, Skeletal; Ovariectomy; Pulmonary Artery; Rats; Receptors, G-Protein-Coupled; Ventricular Dysfunction; Ventricular Remodeling | 2018 |
Betaine Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibiting Inflammatory Response.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Betaine; Biomarkers; Chemokine CCL2; Cytokines; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Inflammation Mediators; Male; Monocrotaline; Myocardium; NF-kappa B; Pulmonary Artery; Rats | 2018 |
Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition.
Topics: Acetylcholine; Animals; Endothelium; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Flavanones; Hemodynamics; Hypertension, Pulmonary; Male; Mesoderm; Monocrotaline; NF-kappa B; Rats; Rats, Sprague-Dawley; Up-Regulation | 2018 |
Pulmonary Artery Hypertension Model in Rats by Monocrotaline Administration.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Dysfunction, Right | 2018 |
Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Enzyme Activation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; NF-kappa B; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2018 |
Involvement of S100A4/Mts1 and associated proteins in the protective effect of fluoxetine against MCT - Induced pulmonary hypertension in rats.
Topics: Animals; Dose-Response Relationship, Drug; Fluoxetine; Hypertension, Pulmonary; Male; Monocrotaline; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; S100 Calcium-Binding Protein A4; Tumor Suppressor Protein p53 | 2018 |
Dysregulation of miR-135a-5p promotes the development of rat pulmonary arterial hypertension in vivo and in vitro.
Topics: Animals; Cell Proliferation; Cells, Cultured; Hypertension, Pulmonary; Hypoxia; Male; MicroRNAs; Monocrotaline; Rats; Rats, Sprague-Dawley | 2019 |
Effects of toceranib compared with sorafenib on monocrotaline-induced pulmonary arterial hypertension and cardiopulmonary remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Autophagy; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Monocrotaline; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pulmonary Artery; Pyrroles; Rats, Wistar; Signal Transduction; Sorafenib; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
P2X7 receptor is involved in lung injuries induced by ischemia-reperfusion in pulmonary arterial hypertension rats.
Topics: Animals; Cytokines; Disease Models, Animal; Humans; Hypertension, Pulmonary; Inflammation Mediators; Lung Injury; MAP Kinase Signaling System; Monocrotaline; Pulmonary Artery; Purinergic P2X Receptor Antagonists; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Reperfusion Injury | 2018 |
Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Pulmonary arterial hypertension induced by a novel method: Twice-intraperitoneal injection of monocrotaline.
Topics: Animals; Cardiac Output; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Injections, Intraperitoneal; Interleukin-6; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha | 2018 |
Analyses of long non-coding RNA and mRNA profiles in right ventricle myocardium of acute right heart failure in pulmonary arterial hypertension rats.
Topics: Animals; Computational Biology; Databases, Genetic; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Lipopolysaccharides; Male; Monocrotaline; Rats, Sprague-Dawley; RNA, Long Noncoding; RNA, Messenger; Transcriptome; Ventricular Dysfunction, Right; Ventricular Function, Right | 2018 |
Calcineurin/NFAT Signaling Modulates Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Apoptosis in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats.
Topics: Animals; Apoptosis; Calcineurin; Cell Hypoxia; Cell Movement; Cell Proliferation; Cyclosporine; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Smooth Muscle; Nerve Tissue Proteins; NFATC Transcription Factors; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Signal Transduction | 2018 |
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Hypertension, Pulmonary; Male; Monocrotaline; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Sprague-Dawley; Resveratrol; Signal Transduction; Stilbenes; Vascular Remodeling | 2018 |
Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Disease Models, Animal; Fabaceae; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; JNK Mitogen-Activated Protein Kinases; Male; Monocrotaline; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Plant Oils; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Signal Transduction; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Oxygen therapy may worsen the survival rate in rats with monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Oxygen Inhalation Therapy; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Survival Rate | 2018 |
Bone Marrow-Derived Endothelial Progenitor Cells Contribute to Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibition of Store-Operated Ca
Topics: Animals; Bone Marrow Cells; Calcium Channels; Endothelial Progenitor Cells; Gene Expression Regulation; Hypertension, Pulmonary; Monocrotaline; Rats; Rats, Sprague-Dawley | 2018 |
17β-estradiol preserves right ventricular function in rats with pulmonary arterial hypertension: an echocardiographic and histochemical study.
Topics: Animals; Biomarkers; Disease Models, Animal; Echocardiography; Estradiol; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Natriuretic Peptide, Brain; Rats, Sprague-Dawley; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2019 |
Nanoparticle-Mediated Targeting of Pitavastatin to Small Pulmonary Arteries and Leukocytes by Intravenous Administration Attenuates the Progression of Monocrotaline-Induced Established Pulmonary Arterial Hypertension in Rats.
Topics: Administration, Intravenous; Animals; Disease Progression; Drug Delivery Systems; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Leukocytes; Male; Monocrotaline; Nanoparticles; Pulmonary Artery; Quinolines; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2018 |
miR‑371b‑5p inhibits endothelial cell apoptosis in monocrotaline‑induced pulmonary arterial hypertension via PTEN/PI3K/Akt signaling pathways.
Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Gene Expression Profiling; Genes, Reporter; Humans; Hypertension, Pulmonary; Male; MicroRNAs; Models, Biological; Monocrotaline; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Signal Transduction; Transcription Factor AP-1 | 2018 |
Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imines; Male; Mice, Knockout; Monocrotaline; Pulmonary Artery; Pyridines; Rats, Sprague-Dawley; Receptor, PAR-1; Thrombin; Vascular Remodeling; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Eulophia macrobulbon extract relaxes rat isolated pulmonary artery and protects against monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Calcium; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Orchidaceae; Plant Extracts; Plant Tubers; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Thailand; Vasodilation | 2018 |
LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT
Topics: Angiogenesis Inducing Agents; Animals; Becaplermin; Cell Proliferation; Hypertension, Pulmonary; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; RNA, Long Noncoding | 2018 |
AOS ameliorates monocrotaline-induced pulmonary hypertension by restraining the activation of P-selectin/p38MAPK/NF-κB pathway in rats.
Topics: Alginates; Animals; Cell Nucleus; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; NF-kappa B; NF-KappaB Inhibitor alpha; Oligosaccharides; P-Selectin; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
CLIC4/Arf6 Pathway.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Antihypertensive Agents; Bone Morphogenetic Protein Receptors, Type II; Cells, Cultured; Chloride Channels; Disease Models, Animal; Endothelial Cells; Humans; Hypertension, Pulmonary; Hypoxia; Inflammation Mediators; Mice, Inbred C57BL; Mitochondrial Proteins; Molecular Targeted Therapy; Monocrotaline; Proteomics; Pulmonary Artery; Rats; RNA, Small Interfering; RNAi Therapeutics; Signal Transduction; Triazoles | 2019 |
C-Type Natriuretic Peptide Ameliorates Lipopolysaccharide-Induced Cardiac Dysfunction in Rats with Pulmonary Arterial Hypertension.
Topics: Animals; Cyclic GMP; Heart Diseases; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lipopolysaccharides; Male; Monocrotaline; Natriuretic Peptide, C-Type; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2018 |
Therapeutic effects of the selective farnesoid X receptor agonist obeticholic acid in a monocrotaline-induced pulmonary hypertension rat model.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Chenodeoxycholic Acid; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 2019 |
Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-β1 Signaling.
Topics: Animals; Caspase Inhibitors; Cysteine Endopeptidases; Extracellular Matrix Proteins; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Inflammation; Lung; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Middle Aged; Monocrotaline; Pyrroles; Rats; Severity of Illness Index; Signal Transduction; Transforming Growth Factor beta1; Vascular Remodeling | 2019 |
Monocrotaline pyrrole induces pulmonary endothelial damage through binding to and release from erythrocytes in lung during venous blood reoxygenation.
Topics: Animals; Endothelial Cells; Endothelium; Erythrocytes; Hypertension, Pulmonary; Lung; Monocrotaline; Oxygen; Rats; Rats, Sprague-Dawley | 2019 |
Exploration of the Notch3-HES5 signal pathway in monocrotaline-induced pulmonary hypertension using rat model.
Topics: Animals; Arterial Pressure; Arterioles; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats, Sprague-Dawley; Receptor, Notch3; Repressor Proteins; Signal Transduction; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2019 |
Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMP/cGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Collagen Type I; Collagen Type I, alpha 1 Chain; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Epithelium; Fibronectins; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Inflammation; Lung; Monocrotaline; Phosphodiesterase 5 Inhibitors; Rats, Wistar; Transforming Growth Factor beta | 2019 |
Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition.
Topics: Animals; Beer; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Enzymologic; Hypertension, Pulmonary; Male; Monocrotaline; Propiophenones; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Vascular Remodeling | 2019 |
Effects of vasopressin during a pulmonary hypertensive crisis induced by acute hypoxia in a rat model of pulmonary hypertension.
Topics: Acute Disease; Animals; Drug Evaluation, Preclinical; Echocardiography; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Nordefrin; Oxygen; Partial Pressure; Phenylephrine; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasopressins | 2019 |
MicroRNA‑132 mediates proliferation and migration of pulmonary smooth muscle cells via targeting PTEN.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Humans; Hypertension, Pulmonary; Male; MicroRNAs; Monocrotaline; Muscle, Smooth, Vascular; PTEN Phosphohydrolase; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley | 2019 |
Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment.
Topics: Adenosine Triphosphatases; Administration, Oral; Adrenergic beta-1 Receptor Antagonists; Animals; Disease Models, Animal; Energy Metabolism; Heart Failure; Hypertension, Pulmonary; Male; Metoprolol; Mitochondria; Monocrotaline; Myocytes, Cardiac; Myofibrils; Oxidative Phosphorylation; Placebo Effect; Rats; Rats, Wistar; Reactive Oxygen Species; Ventricular Function, Right | 2019 |
Energy Metabolism in the Failing Right Ventricle: Limitations of Oxygen Delivery and the Creatine Kinase System.
Topics: Adrenergic beta-Antagonists; Animals; Creatine Kinase; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Heart Failure; Hypertension, Pulmonary; Hypoxia; Male; Mitochondria; Monocrotaline; Muscle Cells; Oxygen; Rats; Ventricular Dysfunction, Right | 2019 |
Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Protective Agents; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Silybin; Treatment Outcome | 2019 |
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Gene Expression Regulation; Gene Ontology; Hypertension, Pulmonary; Metformin; Microarray Analysis; Monocrotaline; Pulmonary Artery; Rats, Wistar; RNA, Long Noncoding; RNA, Messenger; Vascular Remodeling | 2019 |
Function of Adipose-Derived Mesenchymal Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension through miR-191 via Regulation of BMPR2.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Cell Line; Cell Proliferation; Endothelial Cells; Exosomes; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Mesenchymal Stem Cells; MicroRNAs; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2019 |
Attenuating Pulmonary Hypertension by Protecting the Integrity of Glycocalyx in Rats Model of Pulmonary Artery Hypertension.
Topics: Animals; Biomarkers; Disease Models, Animal; Glycocalyx; Heparin; Hyaluronic Acid; Hypertension, Pulmonary; Monocrotaline; Proteoglycans; Rats; Syndecan-1 | 2019 |
Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Female; Fibrosis; Heart; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Skeletal; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling; Ventricular Function, Right | 2019 |
Combination therapy improves vascular volume in female rats with pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Drug Therapy, Combination; Echocardiography; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Phenylpropionates; Pneumonectomy; Pulmonary Artery; Pyridazines; Rats; Rats, Sprague-Dawley; Tadalafil; Vascular Remodeling; Vasoconstriction; Ventricular Dysfunction, Right; X-Ray Microtomography | 2019 |
Protective effects of 18β-glycyrrhetinic acid on pulmonary arterial hypertension via regulation of Rho A/Rho kinsase pathway.
Topics: Animals; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation; Glycyrrhetinic Acid; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Smooth Muscle; Protective Agents; Protein Phosphatase 1; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vascular Remodeling | 2019 |
Circulating Plasma Metabolomic Profiles Differentiate Rodent Models of Pulmonary Hypertension and Idiopathic Pulmonary Arterial Hypertension Patients.
Topics: Adult; Animals; Biomarkers; Case-Control Studies; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Hypoxia; Male; Metabolomics; Methionine; Monocrotaline; Rats, Sprague-Dawley; Urea | 2019 |
Letter by Wang and Guo regarding article Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Topics: Humans; Hypertension, Pulmonary; Metformin; Monocrotaline; Pulmonary Artery; RNA, Long Noncoding; RNA, Messenger; Vascular Remodeling | 2019 |
Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway.
Topics: 2-Methoxyestradiol; Anilides; Animals; Atrial Natriuretic Factor; Bosentan; Gene Expression Regulation; Glyburide; Heart Atria; Hydrogen Sulfide; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; KATP Channels; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Organ Culture Techniques; Oxygen; Pinacidil; Potassium Channel Blockers; PPAR gamma; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfides | 2019 |
Inhibition of overactive transforming growth factor-β signaling by prostacyclin analogs in pulmonary arterial hypertension.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Codon, Nonsense; Epoprostenol; Familial Primary Pulmonary Hypertension; HEK293 Cells; Humans; Hypertension, Pulmonary; Lung; Male; MAP Kinase Signaling System; Mice; Monocrotaline; Myocytes, Smooth Muscle; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Smad3 Protein; Transforming Growth Factor beta1 | 2013 |
The beneficial impact of fasudil and sildenafil on monocrotaline-induced pulmonary hypertension in rats: a hemodynamic and biochemical study.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cholesterol, HDL; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Natriuretic Peptide, Brain; Phosphodiesterase 5 Inhibitors; Piperazines; Protein Kinase Inhibitors; Purines; Rats; Rats, Wistar; rho-Associated Kinases; Sildenafil Citrate; Sulfones; Vascular Endothelial Growth Factor A | 2013 |
Sodium butyrate inhibits platelet-derived growth factor-induced proliferation and migration in pulmonary artery smooth muscle cells through Akt inhibition.
Topics: Acetylation; Animals; Butyric Acid; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Chromones; Familial Primary Pulmonary Hypertension; Gene Expression; Histone Deacetylase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Morpholines; Myocytes, Smooth Muscle; Phosphorylation; Platelet-Derived Growth Factor; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Tissue Culture Techniques | 2013 |
Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension.
Topics: Animals; Apoptosis; Benzamides; Cell Proliferation; Cells, Cultured; Fluoxetine; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hypertension, Pulmonary; Imatinib Mesylate; Male; Monocrotaline; Myocytes, Smooth Muscle; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrimidines; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
A lymphocyte-dependent mode of action for imatinib mesylate in experimental pulmonary hypertension.
Topics: Animals; Apoptosis; Benzamides; Cytokines; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Immunomodulation; Leukocyte Count; Lymphocyte Depletion; Lymphocytes; Male; Monocrotaline; Myocytes, Cardiac; Piperazines; Pyrimidines; Rats; Rats, Inbred F344; Rats, Nude | 2013 |
Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.
Topics: Adult; Aged; Animals; Apoptosis; Arterial Pressure; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Glycation End Products, Advanced; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; S100 Proteins; Signal Transduction; STAT3 Transcription Factor; Transfection; Up-Regulation | 2013 |
Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline-induced pulmonary hypertension in rats.
Topics: Adenosine A2 Receptor Agonists; Administration, Oral; Animals; Benzamides; Collagen; Endothelium, Vascular; Hemodynamics; Hydrazones; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Molecular Docking Simulation; Monocrotaline; Pulmonary Artery; Rats, Wistar; Receptors, Adenosine A2 | 2013 |
Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Arterial Pressure; Caveolin 1; Endothelium, Vascular; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Interleukin-1beta; Male; Monocrotaline; NF-kappa B; Nitric Oxide Synthase Type III; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley; Spirostans; Thromboplastin | 2013 |
Pyrrolidine dithiocarbamate attenuates the development of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Disease Models, Animal; Endothelium, Vascular; Erythrocytes; Familial Primary Pulmonary Hypertension; Hematocrit; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates | 2013 |
Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model.
Topics: Animals; Benzimidazoles; Carbocyanines; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Disease Models, Animal; Fluorescent Dyes; Free Radical Scavengers; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypoxia; Ion Channels; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitochondrial Proteins; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Pulmonary Artery; Rats; Reactive Oxygen Species; RNA, Small Interfering; Uncoupling Protein 2 | 2013 |
Right ventricular electrical remodeling and arrhythmogenic substrate in rat pulmonary hypertension.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Collagen Type I; Connexin 43; Death, Sudden, Cardiac; Drug Therapy, Combination; Epoprostenol; Gene Expression Regulation; Heart; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Organ Culture Techniques; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Ventricular Dysfunction, Right; Ventricular Remodeling; Voltage-Sensitive Dye Imaging | 2013 |
Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension.
Topics: Animals; Atrophy; Body Weight; Diaphragm; Disease Models, Animal; Eating; Hypertension, Pulmonary; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle Contraction | 2013 |
Pathophysiological roles of nuclear factor kappaB (NF-kB) in pulmonary arterial hypertension: effects of synthetic selective NF-kB inhibitor IMD-0354.
Topics: Animals; Antihypertensive Agents; Apoptosis; Benzamides; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Feedback, Physiological; Fibroblast Growth Factor 2; Hypertension, Pulmonary; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors; Tissue Plasminogen Activator; Transcription Factor RelA; Ventricular Function, Right; Ventricular Pressure | 2013 |
The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension.
Topics: Adolescent; Adult; Animals; Case-Control Studies; Cell Proliferation; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Imidazoles; Male; Monocrotaline; Nitric Oxide; Oxidative Stress; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sulfones; Triazines; Vardenafil Dihydrochloride; Young Adult | 2013 |
ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Arterial Pressure; Cytoprotection; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Naphthalenes; Neointima; Peptide Fragments; Peptidyl-Dipeptidase A; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Resorcinols; Severity of Illness Index; Time Factors; Vasodilation | 2013 |
Diminazene aceturate improves autonomic modulation in pulmonary hypertension.
Topics: Angiotensin-Converting Enzyme 2; Animals; Antihypertensive Agents; Arterial Pressure; Autonomic Nervous System; Diminazene; Heart Rate; Hypertension, Pulmonary; Male; Monocrotaline; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley | 2013 |
Oral administration of a novel long-acting prostacyclin agonist with thromboxane synthase inhibitory activity for pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Epoprostenol; Hepatocyte Growth Factor; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Pyridines; Rats; Rats, Wistar; Thromboxane B2; Thromboxane-A Synthase | 2013 |
Impact of dietary iron restriction on the development of monocrotaline-induced pulmonary vascular remodeling and right ventricular failure in rats.
Topics: Animals; Antimicrobial Cationic Peptides; Gene Expression; Hepcidins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Iron, Dietary; Kaplan-Meier Estimate; Lung; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Transferrin; Reverse Transcriptase Polymerase Chain Reaction; Ventricular Dysfunction, Right; Ventricular Function, Right | 2013 |
Distinct loading conditions reveal various patterns of right ventricular adaptation.
Topics: Adaptation, Physiological; Animals; Arteriovenous Shunt, Surgical; Constriction; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Heart Failure; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Models, Cardiovascular; Monocrotaline; Myocardial Contraction; Physical Exertion; Pulmonary Artery; Rats; Rats, Wistar; Stroke Volume; Time Factors; Ultrasonography; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure | 2013 |
Novel oral prostacyclin analog with thromboxane synthase inhibitory activity for management of pulmonary arterial hypertension.
Topics: Animals; Epoprostenol; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Pyridines; Thromboxane-A Synthase | 2013 |
Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Gene Transfer Techniques; Heart Ventricles; HEK293 Cells; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Random Allocation; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Treatment Outcome | 2013 |
Down-regulation of TRPM8 in pulmonary arteries of pulmonary hypertensive rats.
Topics: Animals; Cations; Down-Regulation; Fura-2; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Manganese; Menthol; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; TRPM Cation Channels; Vasodilation | 2013 |
Effect of thrombomodulin on the development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Antithrombin III; Blotting, Western; Chemokine CCL2; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kaplan-Meier Estimate; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Peptide Hydrolases; Rats; Rats, Sprague-Dawley; Thrombomodulin | 2014 |
The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Catalase; Female; Glutathione; Glutathione Transferase; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Liver; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sex Characteristics; Superoxide Dismutase; Ventricular Pressure | 2013 |
[Changes of apelin and its receptor in lung tissue of rats with pulmonary hypertension induced by monocrotaline].
Topics: Animals; Apelin; Apelin Receptors; Hypertension, Pulmonary; Intercellular Signaling Peptides and Proteins; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled | 2013 |
Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits.
Topics: Animals; Cyclooxygenase 1; Cytochrome P-450 Enzyme System; Disease Models, Animal; Endothelial Cells; Epoprostenol; Familial Primary Pulmonary Hypertension; Genetic Therapy; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Infusions, Intravenous; Intramolecular Oxidoreductases; Male; Monocrotaline; Rats; Rats, Inbred F344; Stem Cell Transplantation; Survival Rate; Tissue Engineering; Transfection; Treatment Outcome | 2013 |
[Research on effects of bone marrow mononuclear cells implantation on model of experimental pulmonary artery hypertension].
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Dogs; Familial Primary Pulmonary Hypertension; Female; Hypertension, Pulmonary; Leukocytes, Mononuclear; Male; Monocrotaline; Rats | 2013 |
Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice.
Topics: Animals; Apoptosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Lineage; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Mice; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Phenotype; RNA, Messenger; Stem Cells; Time Factors; Transport Vesicles | 2013 |
[Fasudil reverses monocrotaline-induced pulmonary hypertension in rats].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Male; Monocrotaline; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Treatment Outcome | 2013 |
Exhaled nitric oxide measurement to monitor pulmonary hypertension in a pneumonectomy-monocrotaline rat model.
Topics: Animals; Arginine; Arterial Pressure; Biomarkers; Biopterins; Exhalation; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide; Pneumonectomy; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley | 2013 |
Reversibility of the monocrotaline pulmonary hypertension rat model.
Topics: Animals; Arterioles; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Echocardiography; Hemodynamics; Hypertension, Pulmonary; Liver; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar | 2013 |
Suppression of cyclin D1 by plasmid-based short hairpin RNA ameliorated experimental pulmonary vascular remodeling.
Topics: Animals; Cell Proliferation; Cyclin D1; Disease Models, Animal; Down-Regulation; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Transfection | 2013 |
Benefit of combined therapy with nicorandil and colchicine in preventing monocrotaline-induced rat pulmonary arterial hypertension.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; bcl-2-Associated X Protein; Caspase 3; Cell Cycle Checkpoints; Cell Line; Colchicine; Connexin 43; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Heart Ventricles; Hypertension, Pulmonary; Lung; Male; Matrix Metalloproteinase 9; Monocrotaline; Myocytes, Smooth Muscle; NF-kappa B; Nicorandil; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Smad3 Protein; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2013 |
Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension.
Topics: Acetylcholine; Angiography; Animals; Disease Models, Animal; Endothelium, Vascular; Fluoxetine; Humans; Hypertension, Pulmonary; Lung; Male; Molecular Targeted Therapy; Monocrotaline; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Vasodilation | 2013 |
Protection of oral hydrogen water as an antioxidant on pulmonary hypertension.
Topics: Administration, Oral; Analysis of Variance; Animals; Antioxidants; Atrial Natriuretic Factor; Blood Pressure; Blotting, Western; Hydrogen; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intercellular Adhesion Molecule-1; Models, Animal; Monocrotaline; Rats | 2013 |
Long-term research of stem cells in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Histocytochemistry; Hypertension, Pulmonary; Immunohistochemistry; Injections, Subcutaneous; Lung; Male; Mesenchymal Stem Cells; Microscopy; Monocrotaline; Rats, Sprague-Dawley; Stem Cell Transplantation; Treatment Outcome | 2014 |
Imatinib attenuates monocrotaline pulmonary hypertension and has potent vasodilator activity in pulmonary and systemic vascular beds in the rat.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Benzamides; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Muscle, Smooth, Vascular; Phosphodiesterase 4 Inhibitors; Piperazines; Potassium Channel Blockers; Protein Kinase Inhibitors; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Vasoconstriction; Vasodilation; Vasodilator Agents | 2013 |
SDF-1α in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats.
Topics: Aerosols; Animals; Chemokine CXCL12; Chitosan; Dextran Sulfate; Humans; Hypertension, Pulmonary; Jurkat Cells; Male; Monocrotaline; Nanoparticles; Polysaccharides; Rats; Rats, Sprague-Dawley; Time Factors | 2013 |
Soluble JAGGED1 inhibits pulmonary hypertension by attenuating notch signaling.
Topics: Adenoviridae; Animals; Binding Sites; Calcium-Binding Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypoxia; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Male; Membrane Proteins; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Phenotype; Promoter Regions, Genetic; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Notch1; Receptor, Notch3; Receptors, Notch; Serrate-Jagged Proteins; Signal Transduction; Time Factors; Trans-Activators; Transduction, Genetic; Transfection | 2013 |
Inhibition of the Ca(2+)-sensing receptor rescues pulmonary hypertension in rats and mice.
Topics: Animals; Blotting, Western; Calcium; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Myocardium; Poisons; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Calcium-Sensing | 2014 |
[Protective effects of beraprost plus simvastatin on monocrotaline-induced pulmonary arterial hypertension in rats].
Topics: Animals; Drug Therapy, Combination; Epoprostenol; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Simvastatin | 2013 |
The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Apoptosis; Cell Proliferation; Enzyme Activation; Humans; Hypertension, Pulmonary; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocrotaline; Muscle, Smooth, Vascular; Phosphorylation; Pulmonary Artery; Rats; Receptor Protein-Tyrosine Kinases; Suramin | 2013 |
Extracellular vesicles: small but strong.
Topics: Animals; Bone Marrow Cells; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Lung; Monocrotaline; Stem Cells; Transport Vesicles | 2013 |
Endothelial fate mapping in mice with pulmonary hypertension.
Topics: Actins; Alkylating Agents; Animals; Antigens, CD; Cadherins; Cell Lineage; Disease Models, Animal; Endothelium, Vascular; Hemodynamics; Humans; Hypertension, Pulmonary; Integrases; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocrotaline; Neointima; Pneumonectomy; Pulmonary Artery; von Willebrand Factor | 2014 |
Single intraperitoneal injection of monocrotaline as a novel large animal model of chronic pulmonary hypertension in Tibet minipigs.
Topics: Animals; Disease Models, Animal; Echocardiography; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Artery; Swine; Swine, Miniature | 2013 |
Telmisartan attenuates monocrotaline-induced pulmonary artery endothelial dysfunction through a PPAR gamma-dependent PI3K/Akt/eNOS pathway.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; PPAR gamma; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Telmisartan | 2014 |
Role for DNA damage signaling in pulmonary arterial hypertension.
Topics: Adult; Aged; Animals; Apoptosis; Benzimidazoles; Cell Proliferation; Cells, Cultured; Disease Models, Animal; DNA Damage; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Male; MicroRNAs; Middle Aged; Monocrotaline; NFATC Transcription Factors; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Signal Transduction | 2014 |
Cervical ganglion block attenuates the progression of pulmonary hypertension via nitric oxide and arginase pathways.
Topics: Amides; Anesthetics, Local; Animals; Arginase; Autonomic Nerve Block; Blood Pressure; Cardiomegaly; Ganglia, Sympathetic; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Ropivacaine; Superior Cervical Ganglion | 2014 |
4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation.
Topics: Animals; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Fenclonine; Hypertension, Pulmonary; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Phenylalanine; Pneumonia; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tryptophan Hydroxylase; Tumor Necrosis Factor-alpha | 2014 |
Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.
Topics: Animals; Arachidonate 15-Lipoxygenase; Blood Pressure; Cell Cycle; Cell Proliferation; Cells, Cultured; Feedback, Physiological; Gene Expression Regulation; Humans; Hydroxyeicosatetraenoic Acids; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Myocytes, Smooth Muscle; Protein Binding; Pulmonary Artery; Rats; Rats, Wistar; Signal Transduction; Telomerase | 2013 |
Oxymatrine prevents hypoxia- and monocrotaline-induced pulmonary hypertension in rats.
Topics: Alkaloids; Animals; Cell Proliferation; Heme Oxygenase-1; Humans; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Myocytes, Smooth Muscle; NF-E2-Related Factor 2; Pulmonary Artery; Quinolizines; Rats; Superoxide Dismutase; Superoxide Dismutase-1 | 2014 |
Ethyl pyruvate ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Administration Schedule; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Hypertension, Pulmonary; Injections, Intraperitoneal; Interleukin-6; Male; Monocrotaline; Pyruvates; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2014 |
Inhalation of the BK(Ca)-opener NS1619 attenuates right ventricular pressure and improves oxygenation in the rat monocrotaline model of pulmonary hypertension.
Topics: Administration, Inhalation; Animals; Becaplermin; Benzimidazoles; Blotting, Western; Cell Proliferation; Cells, Cultured; Hemodynamics; Hypertension, Pulmonary; Large-Conductance Calcium-Activated Potassium Channels; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocrotaline; Myocytes, Smooth Muscle; Oxygen; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right; Ventricular Pressure | 2014 |
Attenuation of monocrotaline-induced pulmonary hypertension by luminal adeno-associated virus serotype 9 gene transfer of prostacyclin synthase.
Topics: Animals; Cytochrome P-450 Enzyme System; Dependovirus; Enzyme Induction; Gene Expression; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Intramolecular Oxidoreductases; Monocrotaline; Promoter Regions, Genetic; Rats, Inbred F344; Rats, Sprague-Dawley; Transduction, Genetic; Vascular Remodeling | 2014 |
Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension and survival in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Drug Therapy, Combination; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones | 2014 |
Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension.
Topics: Animals; Autoradiography; Azepines; Binding, Competitive; Case-Control Studies; Heart Failure; Heart Ventricles; Humans; Hypertension, Pulmonary; Indoles; Kinetics; Lung; Male; Monocrotaline; Pulmonary Artery; Rats, Sprague-Dawley; Receptors, Endothelin | 2014 |
Palosuran treatment effective as bosentan in the treatment model of pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Quinolines; Rats; Rats, Wistar; Sulfonamides; Urea; Urotensins | 2014 |
Preventive and remedial application of etanercept attenuate monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Anti-Infective Agents; Arterial Pressure; Disease Models, Animal; Etanercept; Hypertension, Pulmonary; Interleukin-6; Lung; Male; Monocrotaline; Pulmonary Artery; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2016 |
Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II; Cell Nucleus; Cytokines; Endothelial Cells; Gene Expression; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; I-kappa B Proteins; Lung; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Monocrotaline; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Receptor, Notch3; Receptors, Notch; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factor RelA | 2014 |
N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity.
Topics: Adenosine A2 Receptor Agonists; Animals; Benzamides; Exercise Tolerance; Hydrazones; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats, Wistar; Receptor, Adenosine A2A; Ultrasonography; Vasodilation | 2014 |
Concurrent rho-kinase and tyrosine kinase platelet-derived growth factor inhibition in experimental pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Becaplermin; Benzamides; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrimidines; Rats; Rats, Wistar; Receptors, Platelet-Derived Growth Factor; rho-Associated Kinases; Ventricular Pressure | 2014 |
NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension.
Topics: Adult; Animals; Arginine; Cell Proliferation; Epinephrine; Female; Humans; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Indoles; Lung; Male; Mice, Inbred C57BL; Monocrotaline; Myocytes, Smooth Muscle; Neuropeptide Y; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Vasoconstriction; Vasoconstrictor Agents; Young Adult | 2014 |
Myocardial and anti-inflammatory effects of chronic bosentan therapy in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Heart Ventricles; Hypertension, Pulmonary; Inflammation; Male; Monocrotaline; Rats; Rats, Wistar; Sulfonamides | 2014 |
Targeted delivery of pulmonary arterial endothelial cells overexpressing interleukin-8 receptors attenuates monocrotaline-induced pulmonary vascular remodeling.
Topics: Adenoviridae; Animals; Arterial Pressure; Cells, Cultured; Chemokine CCL2; Chemokines, CXC; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Female; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages; Monocrotaline; Neutrophil Infiltration; Neutrophils; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovariectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-8; Transduction, Genetic; Up-Regulation; Ventricular Function, Right; Ventricular Remodeling | 2014 |
Serum-glucocorticoid regulated kinase 1 regulates macrophage recruitment and activation contributing to monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Hypertension, Pulmonary; Immediate-Early Proteins; Inflammation; Macrophages; Mice; Mice, Knockout; Monocrotaline; Myocytes, Smooth Muscle; Protein Serine-Threonine Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vascular Remodeling | 2014 |
Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension.
Topics: Adult; Aged, 80 and over; Animals; Antihypertensive Agents; Case-Control Studies; Cell Hypoxia; Cells, Cultured; Collagen; Disease Models, Animal; Elastin; Enzyme Inhibitors; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Isoenzymes; Male; Mice; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein-Lysine 6-Oxidase; Pulmonary Artery; Rats; RNA, Messenger; Ventricular Dysfunction, Right; Young Adult | 2014 |
Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model.
Topics: Animals; Blood Pressure; Body Weight; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelin-1; Guanylate Cyclase; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Nitric Oxide Synthase Type III; Piperazines; Piperidines; Pulmonary Artery; Purines; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfonamides; Vasoconstriction; Xanthines | 2014 |
Adipose-derived regenerative cell therapy inhibits the progression of monocrotaline-induced pulmonary hypertension in rats.
Topics: Adipose Tissue; Animals; Disease Progression; Gene Expression Profiling; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Rats, Wistar; Regenerative Medicine; RNA, Messenger; Stem Cell Transplantation; Survival Analysis; Vascular Remodeling; Weight Gain | 2014 |
Naringenin adds to the protective effect of L-arginine in monocrotaline-induced pulmonary hypertension in rats: favorable modulation of oxidative stress, inflammation and nitric oxide.
Topics: Animals; Anti-Inflammatory Agents; Arginine; Caspase 3; Flavanones; Hypertension, Pulmonary; Inflammation; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxidase; Pulmonary Artery; Rats, Wistar; Tumor Necrosis Factor-alpha | 2014 |
N-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats.
Topics: Acetylcysteine; Animals; Cells, Cultured; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2014 |
Role of VPAC2 receptor in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Ligands; Male; Monocrotaline; Pituitary Adenylate Cyclase-Activating Polypeptide; Poisons; Rats; Rats, Sprague-Dawley; Receptors, Vasoactive Intestinal Peptide, Type II; Receptors, Vasoactive Intestinal Polypeptide, Type I; Vasoactive Intestinal Peptide | 2014 |
NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling.
Topics: Adventitia; Animals; Antihypertensive Agents; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fibroblasts; HEK293 Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection; Up-Regulation | 2014 |
Endothelial cell global positioning system for pulmonary arterial hypertension: homing in on vascular repair.
Topics: Animals; Endothelial Cells; Familial Primary Pulmonary Hypertension; Female; Genetic Therapy; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Receptors, Interleukin-8 | 2014 |
Fasudil reversed MCT-induced and chronic hypoxia-induced pulmonary hypertension by attenuating oxidative stress and inhibiting the expression of Trx1 and HIF-1α.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Hemodynamics; Hydrogen Peroxide; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Malondialdehyde; Monocrotaline; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thioredoxins; Vasodilator Agents | 2014 |
[Tanshinone IIA sulfonate upregulated pulmonary artery smooth muscle peroxisome proliferator-activated receptor γ expression in monocrotaline induced pulmonary hypertension rat].
Topics: Animals; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Phenanthrenes; PPAR gamma; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2014 |
Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline.
Topics: Animals; Arrhythmias, Cardiac; Elastic Modulus; Excitation Contraction Coupling; Heart Conduction System; Hypertension, Pulmonary; Ion Channel Gating; Ion Channels; Mechanotransduction, Cellular; Monocrotaline; Physical Stimulation; Rats; Rats, Wistar; Stress, Mechanical; Systems Biology; Ventricular Dysfunction, Right; Ventricular Remodeling | 2014 |
HMGB1 promotes the development of pulmonary arterial hypertension in rats.
Topics: Animals; Bronchoalveolar Lavage Fluid; Chemokine CCL2; Disease Models, Animal; DNA-Binding Proteins; Endothelin-1; Hemodynamics; HMGB1 Protein; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Interleukin-1beta; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vascular Resistance; Ventricular Dysfunction, Right | 2014 |
Role of oxidative stress, inflammation, nitric oxide and transforming growth factor-beta in the protective effect of diosgenin in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Caspase 3; Diosgenin; Glutathione; Heart Ventricles; Hypertension, Pulmonary; Inflammation; Lung; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxidase; Protective Agents; Pulmonary Artery; Rats, Wistar; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2014 |
Plasmid-based short hairpin RNA against connective tissue growth factor attenuated monocrotaline-induced pulmonary vascular remodeling in rats.
Topics: Animals; Connective Tissue Growth Factor; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Vascular Remodeling | 2014 |
Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension.
Topics: Acetanilides; Animals; Calcium Signaling; Collagen; Disease Models, Animal; Fibrosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Membrane Potentials; Monocrotaline; Myocytes, Cardiac; Myosin Heavy Chains; Piperazines; Pulmonary Artery; Ranolazine; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Sodium Channels; Time Factors; Vascular Remodeling; Vascular Resistance; Ventricular Function, Right; Ventricular Remodeling | 2014 |
A novel adipocytokine, omentin, inhibits monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Cytokines; Hypertension, Pulmonary; Lectins; Male; Monocrotaline; Rats; Rats, Wistar | 2014 |
[Early treatment with hepatocyte growth factor improves pulmonary artery and right ventricular remodeling in rats with pulmonary artery hypertension by modulating cytokines expression].
Topics: Adenoviridae; Animals; Blood Pressure; Cytokines; Disease Models, Animal; Heart Ventricles; Hepatocyte Growth Factor; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Transfection; Ventricular Remodeling | 2014 |
[Hepatocyte growth factor intervention on rats with pulmonary hypertension and effect of endothelial cell membrane microparticles].
Topics: Adenoviridae; Animals; Blood Pressure; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Hepatocyte Growth Factor; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Transfection | 2014 |
Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Cerium; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nanoparticles; Rats; Rats, Sprague-Dawley | 2014 |
Withania somnifera shows a protective effect in monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Cardiotonic Agents; Dose-Response Relationship, Drug; Endothelium, Vascular; Heart; Hypertension, Pulmonary; Lung; Male; Medicine, Ayurvedic; Monocrotaline; Organ Size; Plant Preparations; Plant Roots; Powders; Rats, Sprague-Dawley; Withania | 2015 |
Peptide-micelle hybrids containing fasudil for targeted delivery to the pulmonary arteries and arterioles to treat pulmonary arterial hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Inhalation; Animals; Antihypertensive Agents; Arterial Pressure; Arterioles; Cell-Penetrating Peptides; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Ethanolamines; Hypertension, Pulmonary; Injections, Intravenous; Magnetic Resonance Spectroscopy; Male; Micelles; Monocrotaline; Oligopeptides; Particle Size; Polyethylene Glycols; Pulmonary Artery; Rats, Sprague-Dawley; Solubility; Technology, Pharmaceutical | 2014 |
Adipose-derived stem cells attenuate pulmonary arterial hypertension and ameliorate pulmonary arterial remodeling in monocrotaline-induced pulmonary hypertensive rats.
Topics: Adipose Tissue; Alkaloids; Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Treatment Outcome; Vascular Remodeling | 2015 |
A novel ACE2 activator reduces monocrotaline-induced pulmonary hypertension by suppressing the JAK/STAT and TGF-β cascades with restored caveolin-1 expression.
Topics: Angiotensin-Converting Enzyme 2; Animals; Caveolin 1; Drug Evaluation, Preclinical; Enzyme Activation; Feedback, Physiological; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Janus Kinases; Male; Monocrotaline; Oxazoles; Peptidyl-Dipeptidase A; Pyrimidines; Rats, Sprague-Dawley; STAT Transcription Factors; Transforming Growth Factor beta | 2015 |
Up-regulation of hexokinase1 in the right ventricle of monocrotaline induced pulmonary hypertension.
Topics: Animals; Heart Ventricles; Hexokinase; Hypertension, Pulmonary; Male; Monocrotaline; Random Allocation; Rats; Rats, Sprague-Dawley; Up-Regulation | 2014 |
Rosuvastatin, sildenafil and their combination in monocrotaline-induced pulmonary hypertension in rat.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Biomarkers; Cholesterol, HDL; Disease Models, Animal; Drug Therapy, Combination; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Natriuretic Peptide, Brain; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Purines; Pyrimidines; Rats, Wistar; Rosuvastatin Calcium; Sildenafil Citrate; Sulfonamides; Time Factors; Vascular Endothelial Growth Factor A; Vascular Remodeling; Vasodilator Agents; Ventricular Function, Right; Ventricular Pressure | 2014 |
Intratracheal administration of cyclooxygenase-1-transduced adipose tissue-derived stem cells ameliorates monocrotaline-induced pulmonary hypertension in rats.
Topics: Adipose Tissue; Adult Stem Cells; Animals; Cell Differentiation; Cyclooxygenase 1; Genetic Vectors; Humans; Hypertension, Pulmonary; Lentivirus; Monocrotaline; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation | 2014 |
Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.
Topics: Animals; Apelin; Arterioles; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells; Fibroblast Growth Factor 2; Hemodynamics; Histone Deacetylase Inhibitors; Hydroxamic Acids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Intercellular Signaling Peptides and Proteins; Male; MEF2 Transcription Factors; MicroRNAs; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Transcription, Genetic | 2015 |
Determination of the effects of pulmonary arterial hypertension and therapy on the cardiovascular system of rats by impedance cardiography.
Topics: Animals; Blood Pressure; Bosentan; Cardiography, Impedance; Disease Models, Animal; Drug Therapy, Combination; Echocardiography; Endothelin Receptor Antagonists; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Purines; Rats, Wistar; Sildenafil Citrate; Sulfonamides | 2014 |
Sex differences in stretch-dependent effects on tension and Ca(2+) transient of rat trabeculae in monocrotaline pulmonary hypertension.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Endothelium, Vascular; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Pulmonary Veins; Rats; Rats, Wistar; Sex Characteristics | 2015 |
Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
Topics: Animals; Cells, Cultured; Collagen Type III; Connective Tissue Growth Factor; Disease Models, Animal; Endothelial Cells; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Intraperitoneal; Lung; Male; Mice; Monocrotaline; Receptor, Notch3; Receptors, Notch; Signal Transduction; Thymosin | 2014 |
Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Glycyrrhizic Acid; HMGB1 Protein; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle, Smooth, Vascular; Pneumonia; Pulmonary Artery; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right | 2014 |
Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3 inflammasome activation in rats.
Topics: Animals; Blotting, Western; Carrier Proteins; Disease Models, Animal; Ellagic Acid; Enzyme-Linked Immunosorbent Assay; Hypertension, Pulmonary; Inflammasomes; Male; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 2015 |
Encapsulation of beraprost sodium in nanoparticles: analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension.
Topics: Animals; Capillary Permeability; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Epoprostenol; Hypertension, Pulmonary; Lactic Acid; Male; Mice, Inbred C57BL; Monocrotaline; Nanoparticles; Polyesters; Polyethylene Glycols; Polymers; Pulmonary Artery; Rats, Wistar; Rhodamines | 2015 |
Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Disease Models, Animal; Endothelium, Vascular; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Lung Injury; Macrophages; Male; Mevalonic Acid; Monocrotaline; Nitric Oxide Synthase Type III; Oxygen; Phosphorylation; Pulmonary Edema; Pyrimidines; Rats, Sprague-Dawley; Reperfusion Injury; Rosuvastatin Calcium; Sulfonamides; Up-Regulation | 2015 |
Effects of captopril on cardiovascular reflexes and respiratory mechanisms in rats submitted to monocrotaline-induced pulmonary arterial hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Baroreflex; Captopril; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Wistar; Vascular Remodeling | 2015 |
Poly (ADP-ribose) polymerase-1: an emerging target in right ventricle dysfunction associated with pulmonary hypertension.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Isoquinolines; Male; Mitochondria; Mitochondrial Membranes; Monocrotaline; NAD; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-2; Ventricular Dysfunction, Right | 2015 |
Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imidazoles; Lung; Male; Monocrotaline; Myocardium; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pulmonary Fibrosis; Pyridines; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Signal Transduction; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2015 |
HMG-COA reductase inhibitors: An opportunity for the improvement of imatinib safety. An experimental study in rat pulmonary hypertension.
Topics: Animals; Drug Synergism; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Organ Size; Rats; Rats, Wistar; Rosuvastatin Calcium; Simvastatin | 2015 |
[Effects of rutaecarpine on right ventriclar remodeling in rats with monocrotaline-induced pulmonary hypertension].
Topics: Animals; Antioxidants; Heart Ventricles; Hypertension, Pulmonary; Indole Alkaloids; Male; Malondialdehyde; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Quinazolines; Rats; Ventricular Remodeling | 2014 |
Endothelial-to-mesenchymal transition in pulmonary hypertension.
Topics: Actins; Animals; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Cell Movement; Cell Transdifferentiation; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Gene Expression Profiling; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Mesoderm; Monocrotaline; Mutation; Rats; RNA, Messenger; Sirolimus; Vascular Remodeling; Vimentin | 2015 |
Therapeutic effects of baicalin on monocrotaline-induced pulmonary arterial hypertension by inhibiting inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cytokines; Disease Models, Animal; Flavonoids; Hypertension, Pulmonary; Immunohistochemistry; Lung; Monocrotaline; Pulmonary Artery; Rats, Wistar; Vascular Remodeling | 2015 |
Pathophysiology of infantile pulmonary arterial hypertension induced by monocrotaline.
Topics: Animals; Animals, Newborn; Collagen Type I; Collagen Type III; Disease Models, Animal; Endothelin-1; Female; Heart; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Myocytes, Cardiac; Natriuretic Peptide, Brain; Pyrrolizidine Alkaloids; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Transcription Factors | 2015 |
[Glycoltic metabolism gene changes in left and right ventricles in experimental rat pulmonary arterial hypertension model].
Topics: Animals; Gene Expression; Heart Ventricles; Hemodynamics; Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Rats | 2014 |
Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hemodynamics; Histone Deacetylase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Valproic Acid | 2015 |
Abnormal expression of vesicular transport proteins in pulmonary arterial hypertension in monocrotaline-treated rats.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Caspase 3; Caveolin 1; Disease Models, Animal; Enzyme Activation; Gene Expression; Hypertension, Pulmonary; Male; Monocrotaline; N-Ethylmaleimide-Sensitive Proteins; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; RNA, Messenger; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; Vesicular Transport Proteins | 2015 |
Calorie Restriction Attenuates Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
Topics: Acetylation; Adenoviridae; Animals; Arterial Pressure; Caloric Restriction; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Genetic Vectors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Time Factors; Transduction, Genetic; Vascular Remodeling; Vasodilation; Vasodilator Agents | 2015 |
Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure?
Topics: Administration, Inhalation; Animals; Arterial Pressure; Cardiotonic Agents; Disease Models, Animal; Disease Progression; Dobutamine; Energy Metabolism; Heart Failure; Hexokinase; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; L-Lactate Dehydrogenase; Male; Mitochondria, Heart; Monocrotaline; Oxygen; Oxygen Consumption; Protoporphyrins; Pulmonary Artery; Rats, Wistar; Ventricular Dysfunction, Right; Ventricular Function, Right | 2015 |
Chlorogenic acid inhibits hypoxia-induced pulmonary artery smooth muscle cells proliferation via c-Src and Shc/Grb2/ERK2 signaling pathway.
Topics: Animals; Cell Cycle Proteins; Cell Hypoxia; Cell Proliferation; Chlorogenic Acid; CSK Tyrosine-Protein Kinase; DNA; Down-Regulation; G1 Phase; GRB2 Adaptor Protein; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Monocrotaline; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; src-Family Kinases; Transcription, Genetic; Transcriptional Activation | 2015 |
Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat.
Topics: Animals; Drug Discovery; Humans; Hypertension, Pulmonary; Monocrotaline; Platelet Aggregation; Rats; Receptors, Prostaglandin | 2015 |
Transfer of human hepatocyte growth factor reduces inflammation and prevents pulmonary arterial remodeling in monocrotaline-induced.
Topics: Animals; Cell-Derived Microparticles; Endothelium, Vascular; Gene Transfer Techniques; Hepatocyte Growth Factor; Humans; Hypertension, Pulmonary; Inflammation; Interleukin-6; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2014 |
Nebivolol for improving endothelial dysfunction, pulmonary vascular remodeling, and right heart function in pulmonary hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Benzopyrans; Cell Communication; Cell Culture Techniques; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Ethanolamines; Humans; Hypertension, Pulmonary; Male; Metoprolol; Monocrotaline; Myocytes, Smooth Muscle; Nebivolol; Pulmonary Artery; Rats; Rats, Wistar; Vascular Remodeling | 2015 |
The Therapeutic Effects of Human Mesenchymal Stem Cells Primed with Sphingosine-1 Phosphate on Pulmonary Artery Hypertension.
Topics: Animals; Antimicrobial Cationic Peptides; Blood Pressure; Cathelicidins; Cell Movement; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Humans; Hypertension, Pulmonary; Lysophospholipids; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Monocrotaline; Neovascularization, Physiologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred Lew; Signal Transduction; Sphingosine; Transcription Factors; Vascular Remodeling | 2015 |
Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling.
Topics: Animals; Elongation Factor 2 Kinase; Hypertension, Pulmonary; Male; Matrix Metalloproteinase 2; Monocrotaline; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Pyridines; Pyrimidines; Rats; Rats, Wistar; Reactive Oxygen Species; Vascular Remodeling | 2015 |
Ginsenoside Rb1 attenuates agonist-induced contractile response via inhibition of store-operated calcium entry in pulmonary arteries of normal and pulmonary hypertensive rats.
Topics: Animals; Calcium; Calcium Channels; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Endothelin-1; Gadolinium; Ginsenosides; Hypertension, Pulmonary; Indoles; Male; Monocrotaline; Muscle Contraction; Myocytes, Smooth Muscle; Nifedipine; Panax; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum | 2015 |
Beneficial Effects of Renal Denervation on Pulmonary Vascular Remodeling in Experimental Pulmonary Artery Hypertension.
Topics: Angiotensin II; Animals; Collagen; Dimethylformamide; Dinoprostone; Dogs; Echocardiography; Electrocardiography; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Female; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Kidney; Lung; Male; Monocrotaline; Neurotransmitter Agents; Random Allocation; Renal Artery; Renin-Angiotensin System; Sympathectomy; Vascular Remodeling | 2015 |
Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats With Monocrotaline-induced Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nicorandil; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 5 Inhibitors; Pyridazines; Rats, Wistar; Recovery of Function; Severity of Illness Index; Sildenafil Citrate; Vasodilator Agents; Ventricular Dysfunction, Right; Ventricular Function, Right | 2015 |
Novel assessment of haemodynamic kinetics with acute exercise in a rat model of pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Blood Pressure Monitoring, Ambulatory; Disease Models, Animal; Enzyme Activation; Exercise Therapy; Glycolysis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kinetics; Male; Monocrotaline; Muscle, Skeletal; Myocardium; Nitric Oxide Synthase Type III; Predictive Value of Tests; Pulmonary Artery; Rats, Sprague-Dawley; Telemetry; Ventricular Function, Right; Ventricular Pressure | 2015 |
Delivery of imatinib-incorporated nanoparticles into lungs suppresses the development of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Benzamides; Cells, Cultured; Disease Models, Animal; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nanoparticles; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor | 2015 |
The Effect of Umbilical Cord Blood Derived Mesenchymal Stem Cells in Monocrotaline-induced Pulmonary Artery Hypertension Rats.
Topics: Animals; Cytokines; Disease Models, Animal; Endothelin-1; Fetal Blood; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Matrix Metalloproteinase 2; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A | 2015 |
The effects of mycophenolate mofetil on cytokines and their receptors in pulmonary arterial hypertension in rats.
Topics: Animals; Blood Pressure; Cell Proliferation; Cytokines; Disease Models, Animal; Endothelin-1; Fibroblast Growth Factor 2; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Mycophenolic Acid; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Cytokine; Receptors, Fibroblast Growth Factor | 2015 |
Interruption of CD40 Pathway Improves Efficacy of Transplanted Endothelial Progenitor Cells in Monocrotaline Induced Pulmonary Arterial Hypertension.
Topics: Animals; CD40 Antigens; CD40 Ligand; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelial Progenitor Cells; Hypertension, Pulmonary; Intercellular Adhesion Molecule-1; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Signal Transduction; Stem Cell Transplantation; Vascular Endothelial Growth Factor A | 2015 |
Anti-Endothelin Receptor Type A Autoantibodies in Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension.
Topics: Adult; Animals; Autoantibodies; Cell Proliferation; Cohort Studies; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Profiling; Humans; Hypertension, Pulmonary; In Vitro Techniques; Lupus Erythematosus, Systemic; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Permeability; Proto-Oncogene Proteins c-sis; Rats; Receptor, Endothelin A; Receptor, Platelet-Derived Growth Factor beta; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Vascular Endothelial Growth Factor A | 2015 |
Salvia Miltiorrhiza Bge.f.alba Ameliorates the Progression of Monocrotaline-Induced Pulmonary Hypertension by Protecting Endothelial Injury in Rats.
Topics: Animals; Endothelin-1; Endothelium, Vascular; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Plant Extracts; Poisons; Prostaglandins I; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Thromboxane A2; Transforming Growth Factor beta1; Ventricular Function, Right | 2015 |
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.
Topics: Aging; Animals; Apoptosis; Bone Morphogenetic Protein Receptors, Type II; Cell Membrane Permeability; Densitometry; Endothelial Cells; Gene Expression Profiling; Gene Knock-In Techniques; Growth Differentiation Factor 2; Heart Ventricles; Humans; Hypertension, Pulmonary; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Male; Mice, Inbred C57BL; Monocrotaline; Phosphorylation; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Systole; Transcription, Genetic | 2015 |
[Beneficial effects of renal denervation on pulmonary vascular remodeling in experimental pulmonary artery hypertension].
Topics: Angiotensin II; Animals; Blood Pressure; Denervation; Dogs; Echocardiography; Endothelin-1; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Kidney; Lung; Monocrotaline; Pulmonary Artery; Sympathectomy; Vascular Remodeling | 2015 |
miR-223 reverses experimental pulmonary arterial hypertension.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; DNA Damage; Down-Regulation; Female; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; MicroRNAs; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2015 |
Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Cell Proliferation; Disease Models, Animal; Hydrogen; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NFATC Transcription Factors; Phosphorylation; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Vascular Remodeling | 2015 |
Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats.
Topics: Animals; Apoptosis; Benzothiazoles; Cell Proliferation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Wistar; Toluene; Tumor Suppressor Protein p53 | 2015 |
Melatonin as a preventive and curative therapy against pulmonary hypertension.
Topics: Animals; Antioxidants; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Melatonin; Monocrotaline; Rats; Rats, Long-Evans; Ventricular Dysfunction, Right | 2015 |
Diverse contribution of bone marrow-derived late-outgrowth endothelial progenitor cells to vascular repair under pulmonary arterial hypertension and arterial neointimal formation.
Topics: Animals; Arterioles; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Proliferation; Endothelial Progenitor Cells; Endothelium, Vascular; Femoral Artery; Humans; Hypertension, Pulmonary; Monocrotaline; Neointima; Rats; Vascular Diseases | 2015 |
[Effect of sesamin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary hypertension].
Topics: Animals; Dioxoles; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Hypertension, Pulmonary; Lignans; Lung; Male; Membrane Glycoproteins; Monocrotaline; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2015 |
Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.
Topics: Animals; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex III; Gene Expression Regulation; Glycolysis; Hypertension, Pulmonary; Lung; Male; Membrane Potential, Mitochondrial; Mitochondria; Monocrotaline; Myocytes, Smooth Muscle; Oxidative Phosphorylation; Primary Cell Culture; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2015 |
Inhibition of Notch3 prevents monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Notch3; Receptors, Notch; Signal Transduction | 2015 |
Activation of the phosphatidylinositol 3-kinase/Akt pathway is involved in lipocalin-2-promoted human pulmonary artery smooth muscle cell proliferation.
Topics: Acute-Phase Proteins; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Humans; Hypertension, Pulmonary; Lipocalin-2; Lipocalins; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Up-Regulation; Vascular Remodeling | 2015 |
Influence of imatinib at a low dose and sildenafil on pulmonary hypertension in rats.
Topics: Animals; Blood Pressure; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Protein Kinase Inhibitors; Rats; Rats, Wistar; Sildenafil Citrate; Vasodilator Agents | 2015 |
Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspase 3; Cells, Cultured; Cytokines; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; I-kappa B Proteins; Inflammation Mediators; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pulmonary Artery; Rats; Rats, Wistar; Signal Transduction; Transcription Factor RelA; Vascular Remodeling | 2015 |
Farnesoid-X-receptor expression in monocrotaline-induced pulmonary arterial hypertension and right heart failure.
Topics: Animals; Disease Models, Animal; Gene Expression; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Vascular Remodeling; Ventricular Remodeling | 2015 |
Percutaneous Carbon Dioxide Treatment Using a Gas Mist Generator Attenuates the Development of Right Ventricular Dysfunction in Monocrotaline-induced Pulmonary Hypertensive Rats.
Topics: Aerosols; Animals; Carbon Dioxide; Cardiovascular Agents; Disease Models, Animal; Hemodynamics; HSP72 Heat-Shock Proteins; Hypertension, Pulmonary; Male; Monocrotaline; Myocardium; Nebulizers and Vaporizers; Nitric Oxide Synthase Type III; Phosphorylation; Rats, Wistar; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right | 2015 |
Cardioprotective effects of early and late aerobic exercise training in experimental pulmonary arterial hypertension.
Topics: Animals; Biomarkers; Exercise Tolerance; Hypertension, Pulmonary; Male; Monocrotaline; Physical Conditioning, Animal; Random Allocation; Rats, Wistar; Ventricular Function, Right; Ventricular Remodeling | 2015 |
Role of miR206 in genistein-induced rescue of pulmonary hypertension in monocrotaline model.
Topics: Angiogenesis Inducing Agents; Animals; Capillaries; Electrocardiography; Gene Knockdown Techniques; Genistein; Heart Function Tests; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; MicroRNAs; Monocrotaline; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Vascular Endothelial Growth Factor A | 2015 |
Tetrandrine prevents monocrotaline-induced pulmonary arterial hypertension in rats through regulation of the protein expression of inducible nitric oxide synthase and cyclic guanosine monophosphate-dependent protein kinase type 1.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Benzylisoquinolines; Catalase; Cell Proliferation; Cyclic GMP-Dependent Protein Kinase Type I; Disease Models, Animal; Glutathione; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Oxidative Stress; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase; Time Factors; Vascular Remodeling; Ventricular Remodeling | 2016 |
Inhibition of FGFR Signaling With PD173074 Ameliorates Monocrotaline-induced Pulmonary Arterial Hypertension and Rescues BMPR-II Expression.
Topics: Adolescent; Adult; Animals; Apoptosis; Arterioles; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblast Growth Factor 2; Heart Ventricles; Hemodynamics; Humans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; Signal Transduction; Smad Proteins, Receptor-Regulated; Time Factors; Vascular Remodeling; Young Adult | 2015 |
Effect of all-trans retinoic acids (ATRA) on the expression of α-smooth muscle actin (α-SMA) in the lung tissues of rats with pulmonary arterial hypertension (PAH).
Topics: Actins; Animals; Disease Models, Animal; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tretinoin | 2015 |
A study on the involvement of GABA-transaminase in MCT induced pulmonary hypertension.
Topics: 4-Aminobutyrate Transaminase; Animals; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Norepinephrine; Oxidative Stress; Oxygen; Pneumonia; Rats; Rats, Sprague-Dawley; Survival Analysis; Vigabatrin | 2016 |
Nestin-expressing vascular wall cells drive development of pulmonary hypertension.
Topics: Animals; Calcium-Binding Proteins; Calponins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Green Fluorescent Proteins; Humans; Hypertension, Pulmonary; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Monocrotaline; Muscle, Smooth, Vascular; Nestin; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Vascular Remodeling | 2016 |
Ruscogenin exerts beneficial effects on monocrotaline-induced pulmonary hypertension by inhibiting NF-κB expression.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Humans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Platelet-Derived Growth Factor; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spirostans | 2015 |
Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2015 |
Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline.
Topics: Action Potentials; Animals; Arterial Pressure; Cell Proliferation; Disease Models, Animal; Dogs; Gene Expression Regulation; Hypertension, Pulmonary; Monocrotaline; Neural Conduction; Pulmonary Artery; RNA, Messenger; Sympathectomy; Sympathetic Nervous System; Time Factors; Vascular Remodeling; Vascular Resistance; Vasoconstriction | 2015 |
Pioglitazone alleviates cardiac and vascular remodelling and improves survival in monocrotaline induced pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages, Alveolar; Male; Monocrotaline; Myocytes, Cardiac; Natriuretic Peptide, Brain; Osteopontin; Pioglitazone; PPAR gamma; Pulmonary Artery; Rats, Sprague-Dawley; Thiazolidinediones; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2016 |
Intratracheal Administration of Prostacyclin Analogue-incorporated Nanoparticles Ameliorates the Development of Monocrotaline and Sugen-Hypoxia-induced Pulmonary Arterial Hypertension.
Topics: Adolescent; Adult; Animals; Cell Hypoxia; Cell Proliferation; Child; Disease Models, Animal; Drug Delivery Systems; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Smooth Muscle; Nanoparticles; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors; Young Adult | 2016 |
[Effect of chrysin on expression of NOX4 and NF-κB in right ventricle of monocrotaline-induced pulmonary arterial hypertension of rats].
Topics: Animals; Blotting, Western; Collagen; Disease Models, Animal; Flavonoids; Heart Ventricles; Hypertension, Pulmonary; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Rats; Ventricular Remodeling | 2015 |
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Topics: Acetophenones; Acetylcysteine; Animals; Apoptosis; Calcium; Calcium Channels, L-Type; Cell Proliferation; Gene Expression Regulation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Metalloporphyrins; Monocrotaline; Myocytes, Smooth Muscle; Organ Culture Techniques; Pentose Phosphate Pathway; Phosphorylation; Primary Cell Culture; Pulmonary Artery; Pyruvate Kinase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serine | 2016 |
Reversal of MicroRNA Dysregulation in an Animal Model of Pulmonary Hypertension.
Topics: Animals; Antagomirs; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Gene Expression Regulation; Genetic Therapy; Humans; Hypertension, Pulmonary; Intramolecular Oxidoreductases; Lung; MicroRNAs; Monocrotaline; Oligonucleotides; Rats, Sprague-Dawley | 2016 |
Therapeutic Benefits of Induced Pluripotent Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Adult; Animals; Cells, Cultured; Culture Media, Conditioned; Cytokines; Disease Models, Animal; Down-Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Interferon-gamma; Interleukins; Lung; Macrophages; Male; Monocrotaline; NF-kappa B; Phosphorylation; Pluripotent Stem Cells; Pulmonary Artery; Rats | 2016 |
Development of a servo pump system for in vivo loading of pathological pulmonary artery impedance on the right ventricle of normal rats.
Topics: Animals; Arterial Pressure; Blood Flow Velocity; Cardiac Pacing, Artificial; Disease Models, Animal; Electronics, Medical; Equipment Design; Hemodynamics; Hypertension, Pulmonary; Male; Models, Cardiovascular; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats, Sprague-Dawley; Regional Blood Flow; Time Factors; Vascular Resistance; Ventricular Function, Right | 2016 |
Preventive effect of sildenafil on right ventricular function in rats with monocrotaline-induced pulmonary arterial hypertension.
Topics: Administration, Ophthalmic; Animals; Echocardiography; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats, Sprague-Dawley; Sildenafil Citrate; Vasodilator Agents; Ventricular Function, Right | 2016 |
Protective effects of drag-reducing polymers in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-1beta; Interleukin-6; Male; Monocrotaline; Polyethylene Glycols; Polymers; Pulmonary Artery; Rats; Rats, Wistar; Surface-Active Agents | 2016 |
Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.
Topics: Adventitia; Animals; Bone Morphogenetic Protein Receptors, Type II; Cell Division; Endothelium, Vascular; Fibroblasts; Genetic Predisposition to Disease; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Male; Membrane Potentials; Monocrotaline; Mutation; Myocytes, Smooth Muscle; Nerve Tissue Proteins; ortho-Aminobenzoates; Patch-Clamp Techniques; Potassium Channels, Tandem Pore Domain; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfonamides; Vascular Resistance | 2016 |
Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension.
Topics: Animals; ErbB Receptors; Humans; Hypertension, Pulmonary; Monocrotaline; Muscle, Smooth, Vascular; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Protein Multimerization; Pulmonary Artery; Rats; Signal Transduction; Tyrosine | 2016 |
Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.
Topics: Animals; Blood Pressure; Carnitine; Disease Models, Animal; Disease Progression; Glutathione; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Metabolic Networks and Pathways; Metabolome; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors | 2016 |
Modafinil improves monocrotaline-induced pulmonary hypertension rat model.
Topics: Animals; Benzhydryl Compounds; Body Weight; Cyclic AMP; Disease Models, Animal; Endothelin-1; Gene Expression Regulation; Heart Ventricles; Humans; Hypertension, Pulmonary; Intermediate-Conductance Calcium-Activated Potassium Channels; Male; Modafinil; Monocrotaline; Myocytes, Smooth Muscle; Pressure; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Vasoconstriction | 2016 |
Activation of AMPK Prevents Monocrotaline-Induced Extracellular Matrix Remodeling of Pulmonary Artery.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Enzyme Activation; Extracellular Matrix; Hypertension, Pulmonary; Male; Matrix Metalloproteinase 2; Metformin; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Vascular Remodeling | 2016 |
Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice.
Topics: Animals; Case-Control Studies; Cell-Derived Microparticles; Cells, Cultured; Disease Models, Animal; Exosomes; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Pulmonary Artery; Vascular Remodeling | 2016 |
Priming with ceramide-1 phosphate promotes the therapeutic effect of mesenchymal stem/stromal cells on pulmonary artery hypertension.
Topics: Animals; Anti-Inflammatory Agents; Cell Movement; Cell Proliferation; Ceramides; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; MAP Kinase Signaling System; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Inbred Lew; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells | 2016 |
[Biomarker screening of rat pulmonary hypertension model by transcriptome sequencing].
Topics: Animals; Biomarkers; Focal Adhesion Kinase 1; Hypertension, Pulmonary; Lung; Monocrotaline; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Receptor, TIE-2; Thrombospondin 1; Transcriptome | 2016 |
(1)H NMR-Based Analysis of Serum Metabolites in Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats.
Topics: Animals; Arterial Pressure; Disease Models, Animal; Disease Progression; Energy Metabolism; Glycolysis; Hypertension, Pulmonary; Lipid Metabolism; Male; Metabolome; Methionine; Monocrotaline; Proton Magnetic Resonance Spectroscopy; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2016 |
Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Chalcone; Deoxyguanosine; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Male; Malondialdehyde; Monocrotaline; Oxidative Stress; Quinones; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Vascular Remodeling | 2016 |
Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by activating PI3K/Akt/eNOS signaling.
Topics: Animals; Blotting, Western; Disease Models, Animal; Genistein; Heart Ventricles; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phytoestrogens; Proto-Oncogene Proteins c-akt; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction | 2017 |
Glycoprotein 130 Inhibitor Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Cytokines; Extracellular Signal-Regulated MAP Kinases; Glycoproteins; Hypertension, Pulmonary; Lung; Microtubule-Associated Proteins; Monocrotaline; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Rats, Sprague-Dawley; Survivin; Up-Regulation; Vascular Endothelial Growth Factor A | 2016 |
Nebivolol has a beneficial effect in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiac Output; Hypertension, Pulmonary; Monocrotaline; Nebivolol; Rats; Rats, Sprague-Dawley; Treatment Outcome; Vasodilator Agents | 2016 |
Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model.
Topics: Animals; Apoptosis; Blood Pressure; Caffeic Acids; Drugs, Chinese Herbal; Heart; Hypertension, Pulmonary; Lactates; Lung; Male; Monocrotaline; Myocardium; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Vascular Remodeling | 2016 |
Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Everolimus; Hypertension, Pulmonary; Male; Matrix Metalloproteinases; Monocrotaline; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Thiazoles; Vasodilator Agents | 2017 |
Fractal Dimension in Quantifying Experimental-Pulmonary-Hypertension-Induced Cardiac Dysfunction in Rats.
Topics: Animals; Disease Models, Animal; Echocardiography; Fractals; Heart Failure; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Cardiac; Rats, Wistar; Reference Values; Reproducibility of Results; Stroke Volume; Ventricular Dysfunction, Left; Ventricular Dysfunction, Right | 2016 |
Vascular endothelial-cadherin downregulation as a feature of endothelial transdifferentiation in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Antigens, CD; Apoptosis; Cadherins; Cell Transdifferentiation; Cells, Cultured; Down-Regulation; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Enzyme Activation; Gene Silencing; Hypertension, Pulmonary; Lung; Monocrotaline; Nitric Oxide Synthase Type III; Rats, Wistar; Transcription, Genetic | 2016 |
4-Phenylbutyric Acid Induces Protection against Pulmonary Arterial Hypertension in Rats.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum Stress; Gene Expression; Heat-Shock Proteins; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Phenylbutyrates; Protective Agents; Pulmonary Artery; Random Allocation; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction | 2016 |
Comparison of preventive effect of sildenafil and therapeutic effect of sildenafil treatment in rats with monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Echocardiography; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Ventricular Function, Right; Ventricular Pressure | 2016 |
Local and systemic renin-angiotensin system participates in cardiopulmonary-renal interactions in monocrotaline-induced pulmonary hypertension in the rat.
Topics: Animals; Heart Ventricles; Hypertension, Pulmonary; Kidney; Lung; Male; Monocrotaline; Myocardium; Organ Specificity; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Renin-Angiotensin System | 2016 |
Salusin-β contributes to vascular inflammation associated with pulmonary arterial hypertension in rats.
Topics: Animals; Blotting, Western; Fluorescent Antibody Technique; Hypertension, Pulmonary; Immunoglobulin G; Immunohistochemistry; Inflammation; Intercellular Signaling Peptides and Proteins; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction | 2016 |
[Gα11 expression and effect of sildenafil in muscularization of non-muscular pulmonary arterioles in rat with pulmonary arterial hypertension].
Topics: Animals; Arterioles; Familial Primary Pulmonary Hypertension; GTP-Binding Protein alpha Subunits, Gq-G11; Hypertension, Pulmonary; Lung; Monocrotaline; Muscle, Smooth, Vascular; Osteopontin; Piperazines; Random Allocation; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasodilator Agents | 2016 |
Exercise training contributes to H
Topics: Animals; Exercise; Hydrogen Peroxide; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Rats, Wistar; Vascular Endothelial Growth Factor A | 2016 |
Preventive aerobic training exerts a cardioprotective effect on rats treated with monocrotaline.
Topics: Aerobiosis; Animals; Cardiotonic Agents; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Physical Conditioning, Animal; Rats, Wistar | 2016 |
The role of PDGF-B/TGF-β1/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling.
Topics: Animals; Cattle; Cell Hypoxia; Down-Regulation; Endothelial Cells; Endothelium; Hypertension, Pulmonary; Imatinib Mesylate; Immunoprecipitation; Mesoderm; Monocrotaline; Neprilysin; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Rats; Signal Transduction; Transforming Growth Factor beta1; Vascular Remodeling | 2016 |
Association between endothelial function and micro-vascular remodeling measured by synchrotron radiation pulmonary micro-angiography in pulmonary arterial hypertension.
Topics: Angiography; Animals; Arterial Pressure; Arterioles; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Synchrotrons; Thrombosis; Vascular Endothelial Growth Factor A; Vascular Remodeling | 2016 |
Bortezomib alleviates experimental pulmonary hypertension by regulating intracellular calcium homeostasis in PASMCs.
Topics: Animals; Bone Morphogenetic Protein 4; Bortezomib; Calcium; Calcium Signaling; Cell Hypoxia; Cell Proliferation; Homeostasis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia-Inducible Factor 1, alpha Subunit; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Rats; Rats, Sprague-Dawley; TRPC Cation Channels; Up-Regulation | 2016 |
Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension.
Topics: Animals; Cell Differentiation; Cell Proliferation; Culture Media, Conditioned; Gene Deletion; Humans; Hypertension, Pulmonary; Inflammation; Interleukin 1 Receptor Antagonist Protein; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocrotaline; Myeloid Differentiation Factor 88; Myocytes, Smooth Muscle; NF-kappa B; Rats; Rats, Wistar; Receptors, Interleukin-1 Type I; Signal Transduction | 2016 |
Thymoquinone attenuates monocrotaline-induced pulmonary artery hypertension via inhibiting pulmonary arterial remodeling in rats.
Topics: Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Benzoquinones; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome; Vascular Remodeling | 2016 |
Cardiopulmonary protective effects of the selective FXR agonist obeticholic acid in the rat model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Chenodeoxycholic Acid; Exercise Test; Gene Expression Profiling; Gene Expression Regulation; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Lung; Lung Injury; Male; Monocrotaline; Organ Size; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger | 2017 |
Therapeutic potential of adipose stem cell-derived conditioned medium against pulmonary hypertension and lung fibrosis.
Topics: Adipocytes; Animals; Bleomycin; Culture Media, Conditioned; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Stem Cells | 2016 |
Right ventricular end-diastolic stiffness heralds right ventricular failure in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Diastole; Elasticity; Hypertension, Pulmonary; Male; Monocrotaline; Multivariate Analysis; Rats; Rats, Wistar; ROC Curve; Stroke Volume; Vascular Stiffness; Ventricular Dysfunction, Right; Ventricular Pressure | 2016 |
Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Endothelium, Vascular; Genetic Therapy; Hypertension, Pulmonary; Injections, Spinal; Lung; Mitochondrial Proton-Translocating ATPases; Monocrotaline; Neutrophil Infiltration; Oxidative Phosphorylation Coupling Factors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Vascular Remodeling; Ventricular Dysfunction, Right | 2016 |
Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension.
Topics: Animals; Antihypertensive Agents; Cell Line; Endothelial Cells; Epigenesis, Genetic; Fibroblasts; Genes, Reporter; HEK293 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hypertension, Pulmonary; Isoenzymes; Luciferases; Male; Mice; Monocrotaline; NADPH Oxidase 2; p300-CBP Transcription Factors; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA Polymerase II; Signal Transduction; Transcription, Genetic | 2016 |
Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Case-Control Studies; Disease Models, Animal; Disease Progression; Endothelin-1; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Liver; Lung; Male; Middle Aged; Monocrotaline; Niacinamide; Nicotinamide N-Methyltransferase; Nitric Oxide; Rats, Wistar; Signal Transduction; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right | 2016 |
Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways.
Topics: Animals; Becaplermin; Cell Cycle; Cell Movement; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelin-1; Flow Cytometry; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Liraglutide; Male; Monocrotaline; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-sis; Rats; Rats, Wistar; rho-Associated Kinases | 2016 |
A urotensin II receptor antagonist, KR36676, decreases vascular remodeling and inflammation in experimental pulmonary hypertension.
Topics: Acetamides; Animals; Anti-Inflammatory Agents; Benzoxazines; Collagen; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; MAP Kinase Signaling System; Monocrotaline; NF-kappa B; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2016 |
Monocrotaline-Induced Pulmonary Hypertension Involves Downregulation of Antiaging Protein Klotho and eNOS Activity.
Topics: Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Down-Regulation; Glucuronidase; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Klotho Proteins; Male; Mesenchymal Stem Cells; Monocrotaline; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sirtuin 1; Transfection | 2016 |
Biaxial Properties of the Left and Right Pulmonary Arteries in a Monocrotaline Rat Animal Model of Pulmonary Arterial Hypertension.
Topics: Animals; Anisotropy; Blood Pressure; Compressive Strength; Computer Simulation; Elastic Modulus; Hypertension, Pulmonary; Male; Models, Cardiovascular; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Shear Strength; Stress, Mechanical; Tensile Strength | 2016 |
Sulfur Dioxide Protects Against Collagen Accumulation in Pulmonary Artery in Association With Downregulation of the Transforming Growth Factor β1/Smad Pathway in Pulmonary Hypertensive Rats.
Topics: Animals; Aspartate Aminotransferases; Cells, Cultured; Collagen; Disease Models, Animal; Down-Regulation; Fibroblasts; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Sulfur Dioxide; Transforming Growth Factor beta1; Vascular Remodeling | 2016 |
Effect of Free and Nanoencapsulated Copaiba Oil on Monocrotaline-induced Pulmonary Arterial Hypertension.
Topics: Animals; Fabaceae; Hypertension, Pulmonary; Male; Monocrotaline; Nanocapsules; Plant Oils; Rats; Rats, Wistar; Treatment Outcome | 2017 |
In Vitro and In Vivo Performance of Novel Spray Dried Andrographolide Loaded Scleroglucan Based Formulation for Dry Powder Inhaler.
Topics: Administration, Inhalation; Animals; Antihypertensive Agents; Diterpenes; Drug Carriers; Drug Liberation; Dry Powder Inhalers; Glucans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Particle Size; Rats, Wistar | 2017 |
Lung tissue remodelling in MCT-induced pulmonary hypertension: a proposal for a novel scoring system and changes in extracellular matrix and fibrosis associated gene expression.
Topics: Actins; Animals; Disease Models, Animal; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Fibrosis; Gene Expression Profiling; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Lung; Monocrotaline; Oligonucleotide Array Sequence Analysis; Rats, Sprague-Dawley; Severity of Illness Index; Tenascin; Vascular Remodeling | 2016 |
Evaluation and Treatment of Endoplasmic Reticulum (ER) Stress in Right Ventricular Dysfunction during Monocrotaline-Induced Rat Pulmonary Arterial Hypertension.
Topics: Activating Transcription Factor 6; Animals; Apoptosis; eIF-2 Kinase; Endoplasmic Reticulum Stress; Heart Ventricles; Heat-Shock Proteins; Hypertension, Pulmonary; Male; Membrane Proteins; Monocrotaline; Myocytes, Cardiac; Natriuretic Peptide, Brain; Peptide Fragments; Phenylbutyrates; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factor CHOP; Ventricular Dysfunction, Right | 2016 |
Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model.
Topics: Animals; Disease Models, Animal; Fibrosis; Galectin 3; Hypertension, Pulmonary; Male; Matrix Metalloproteinase 9; Monocrotaline; Rats; Rats, Wistar; STAT3 Transcription Factor; Transforming Growth Factor beta1; Vascular Diseases | 2017 |
Cardiac Body Surface Potentials in Rats with Experimental Pulmonary Hypertension during Ventricular Depolarization.
Topics: Animals; Blood Pressure; Electrocardiography; Electrodes; Female; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Lung; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar | 2016 |
Inhibition of endocan attenuates monocrotaline-induced connective tissue disease related pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Cells, Cultured; Connective Tissue; Disease Models, Animal; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Proteoglycans; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2017 |
Coupling Factor 6 Is Upregulated in Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
Topics: Animals; Epoprostenol; Hemodynamics; Hypertension, Pulmonary; Immunohistochemistry; Mitochondrial Proton-Translocating ATPases; Monocrotaline; Oxidative Phosphorylation Coupling Factors; Random Allocation; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2016 |
Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension.
Topics: Animals; Atrioventricular Node; Disease Models, Animal; Down-Regulation; Echocardiography; Electrocardiography; Electrophysiologic Techniques, Cardiac; Heart Block; Hypertension, Pulmonary; Ion Channels; Male; Monocrotaline; Polymerase Chain Reaction; Rats; Rats, Wistar; Transcriptome | 2016 |
Bucindolol improves right ventricle function in rats with pulmonary arterial hypertension through the reversal of autonomic imbalance.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Electrocardiography; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Propanolamines; Rats; Rats, Wistar; Ventricular Pressure | 2017 |
Aldehyde dehydrogenase 2 protects against oxidative stress associated with pulmonary arterial hypertension.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Animals; Antihypertensive Agents; Benzamides; Benzodioxoles; Cell Line; Cell Movement; Cell Proliferation; Cyclin D1; Gene Expression Regulation; Hypertension, Pulmonary; Male; Malondialdehyde; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocytes, Smooth Muscle; NF-kappa B; Oxidative Stress; Proto-Oncogene Proteins c-myc; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2017 |
Aspirin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing the ERK/MAPK pathway.
Topics: Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Flavonoids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; MAP Kinase Signaling System; Monocrotaline; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Systole; Vascular Remodeling | 2017 |
Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
Topics: Animals; Arterial Pressure; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Focal Adhesion Kinase 1; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Integrin alphaVbeta3; Male; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Osteoprotegerin; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; RNA Interference; Severity of Illness Index; Signal Transduction; Transfection; Vascular Remodeling; Walk Test | 2017 |
Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension.
Topics: Actins; Animals; Antioxidants; Biomimetic Materials; Catalase; Diaphragm; Disease Models, Animal; Glutathione; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Contraction; Muscle Weakness; Organometallic Compounds; Oxidative Stress; Rats; Rats, Wistar; Salicylates; Superoxide Dismutase | 2017 |
Cocktail of Superoxide Dismutase and Fasudil Encapsulated in Targeted Liposomes Slows PAH Progression at a Reduced Dosing Frequency.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arterial Pressure; Chemistry, Pharmaceutical; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Liposomes; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Superoxide Dismutase; Vasodilator Agents | 2017 |
Effects of aerobic exercise training on metabolism of nitric oxide and endothelin-1 in lung parenchyma of rats with pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Parenchymal Tissue; Physical Conditioning, Animal; Rats; Rats, Wistar; Vascular Resistance | 2017 |
Effects of renal denervation on monocrotaline induced pulmonary remodeling.
Topics: Airway Remodeling; Animals; Blood Vessels; Denervation; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Kaplan-Meier Estimate; Kidney; Lung; Male; Monocrotaline; Rats; Renin-Angiotensin System | 2017 |
Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling.
Topics: Adenoviridae; Animals; Bone Morphogenetic Protein Receptors, Type II; Coculture Techniques; Gene Expression Regulation; Genetic Vectors; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; MicroRNAs; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Inbred Lew; Signal Transduction; STAT3 Transcription Factor; Transfection | 2017 |
Inhibition of ubiquitin proteasome function prevents monocrotaline-induced pulmonary arterial remodeling.
Topics: Animals; Bortezomib; Endosomal Sorting Complexes Required for Transport; Gene Expression Regulation, Enzymologic; Hypertension, Pulmonary; Leupeptins; Male; Monocrotaline; Nedd4 Ubiquitin Protein Ligases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; PTEN Phosphohydrolase; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Ubiquitin-Protein Ligases; Vascular Remodeling | 2017 |
5-Aminosalicylic Acid Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats by Increasing the Expression of Nur77.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesalamine; Monocrotaline; NF-kappa B; Nuclear Receptor Subfamily 4, Group A, Member 1; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Survival Rate | 2017 |
Protective effects of aloperine on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Antioxidants; Biomarkers; Dose-Response Relationship, Drug; Echocardiography; Electrocardiography; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Oxidative Stress; Piperidines; Protective Agents; Pulmonary Artery; Pulmonary Circulation; Quinolizidines; Rats; Rats, Sprague-Dawley | 2017 |
Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease.
Topics: Animals; Arterial Pressure; Chronic Disease; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Severity of Illness Index; Vascular Resistance | 2017 |
Effects of Sevoflurane on Hemodynamics and Inducible Nitric Oxide Synthase/Soluble Guanylate Cyclase Signaling Pathway in a Rat Model of Pulmonary Arterial Hypertension.
Topics: Animals; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Methyl Ethers; Monocrotaline; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sevoflurane; Signal Transduction; Soluble Guanylyl Cyclase; Ventricular Function, Right | 2017 |
Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway.
Topics: Animals; Cytokines; Down-Regulation; Drug Evaluation, Preclinical; Heart; Hemodynamics; Hypertension, Pulmonary; Inflammation Mediators; Interleukin-6; Lung; Male; MAP Kinase Signaling System; Monocrotaline; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Thymic Factor, Circulating | 2008 |
Celecoxib but not the combination of celecoxib+atorvastatin prevents the development of monocrotaline-induced pulmonary hypertension in the rat.
Topics: Acetylcholine; Animals; Atorvastatin; Blotting, Western; Body Weight; Caspase 3; Celecoxib; Cyclooxygenase Inhibitors; Disease Progression; Drug Combinations; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Nitric Oxide Synthase Type III; Pulmonary Artery; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Sulfonamides; Survival Analysis; Vasodilator Agents | 2008 |
[Contribution of circulating platelet and leukocyte activation to primary pulmonary hypertension in rats].
Topics: Animals; Blood Platelets; Fibrinogen; Hypertension, Pulmonary; Leukocytes; Male; Monocrotaline; Platelet Aggregation; Platelet Count; Random Allocation; Rats; Rats, Sprague-Dawley | 2008 |
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Immunohistochemistry; Mice; Monocrotaline; Pulmonary Artery; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
Effects of TNF-alpha blockade in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Etanercept; Heart Failure; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunoglobulin G; Male; Monocrotaline; Random Allocation; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2008 |
Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.
Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; B-Lymphocytes; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Chemokines; Disease Models, Animal; Endothelium, Vascular; Heterozygote; Hypertension, Pulmonary; Inflammation; Lung; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocrotaline; Mutation; Pressure; Pulmonary Artery; Receptors, Transforming Growth Factor beta; RNA, Messenger; T-Lymphocytes; Time Factors; Transduction, Genetic; Ventricular Function, Right | 2008 |
Total ginsenosides inhibit the right ventricular hypertrophy induced by monocrotaline in rats.
Topics: Animals; Blood Pressure; Blotting, Western; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ginsenosides; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mitogen-Activated Protein Kinases; Monocrotaline; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Panax; Poisons; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction | 2008 |
Endothelin-3-dependent pulmonary vasoconstriction in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Endothelin-3; Fluorescent Antibody Technique; Hypertension, Pulmonary; Lung; Male; Microscopy, Confocal; Monocrotaline; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Vasoconstriction | 2008 |
Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Hemodynamics; Hypertension, Pulmonary; Lipid Peroxidation; Lung; Male; Monocrotaline; Rats; Rats, Wistar; Sulfur Dioxide | 2008 |
[Quantitative and functional changes of circulating endothelial progenitor cells in dogs with dehydromonocrotaline-induced pulmonary artery hypertension].
Topics: Animals; Cell Count; Cells, Cultured; Disease Models, Animal; Dogs; Endothelial Cells; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Circulation; Stem Cells | 2008 |
CPU0213, a non-selective ETA/ETB receptor antagonist, improves pulmonary arteriolar remodeling of monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Arterioles; Calcium Channel Blockers; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Female; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nifedipine; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B | 2009 |
Hemin treatment abrogates monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Blotting, Northern; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Hemin; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pneumonia; Poisons; Rats; Rats, Sprague-Dawley; RNA; Tumor Necrosis Factor-alpha | 2008 |
Novel approach with intratracheal administration of microgelatin hydrogel microspheres incorporating basic fibroblast growth factor for rescue of rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Gas Analysis; Body Weight; Disease Progression; Fibroblast Growth Factor 2; Gelatin; Hemodynamics; Hydrogels; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Microspheres; Monocrotaline; Rats; Rats, Wistar; Trachea | 2008 |
Upregulation of GLUT-4 in right ventricle of rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Glucose Transporter Type 4; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Up-Regulation | 2008 |
Marrow cell infusion attenuates vascular remodeling in a murine model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Blood Vessels; Bone Marrow Cells; Bone Marrow Transplantation; Disease Models, Animal; Female; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Sodium Chloride; Vimentin; Whole-Body Irradiation | 2009 |
Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Injections, Subcutaneous; Lung; Lung Compliance; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Monocrotaline; Neutrophils; Rats; Rats, Sprague-Dawley; Survival Rate | 2008 |
Molecular and electrical remodeling of L- and T-type Ca(2+) channels in rat right atrium with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Calcium Channels, L-Type; Calcium Channels, T-Type; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Heart Atria; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Monocrotaline; Patch-Clamp Techniques; Rats; Rats, Wistar; RNA, Messenger | 2009 |
Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrot
Topics: Animals; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Image Processing, Computer-Assisted; Imidazoles; Immunohistochemistry; Monocrotaline; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pulmonary Artery; Quinoxalines; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Smad3 Protein; Transforming Growth Factor beta1 | 2009 |
m-Nisoldipine attenuates monocrotaline-induced pulmonary hypertension by suppressing 5-HT/ERK MAPK pathway.
Topics: Animals; Antihypertensive Agents; Extracellular Signal-Regulated MAP Kinases; Hypertension, Pulmonary; Male; Monocrotaline; Nisoldipine; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar; Serotonin; Signal Transduction; Superoxide Dismutase | 2008 |
Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling.
Topics: Administration, Oral; Animals; Blood Pressure; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Fibrillar Collagens; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Natriuretic Peptides; Osteopontin; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Rats, Wistar; RNA, Messenger; Sildenafil Citrate; Stroke Volume; Sulfones; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Ventricular Pressure; Ventricular Remodeling | 2009 |
Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease.
Topics: Animals; Benzamides; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell Movement; Chronic Disease; Disease Models, Animal; Disease Progression; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta | 2009 |
3-Hydroxy-3-methylglutaryl (HMG)-COA reductase inhibitors and phosphodiesterase type V inhibitors attenuate right ventricular pressure and remodeling in a rat model of pulmonary hypertension.
Topics: Animals; Atorvastatin; Disease Models, Animal; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Pravastatin; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Simvastatin | 2009 |
Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Proliferation; Cells, Cultured; Epoxide Hydrolases; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Inbred WKY | 2009 |
The remodeling of connexin in the hypertrophied right ventricular in pulmonary arterial hypertension and the effect of a dual ET receptor antagonist (bosentan).
Topics: Animals; Bosentan; Connexin 43; Disease Models, Animal; Endothelin Receptor Antagonists; Gap Junctions; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microscopy, Confocal; Microscopy, Electron; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Sulfonamides; Ventricular Remodeling | 2009 |
Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Apoptosis; Collagen; Diastole; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Male; Monocrotaline; Myocardial Contraction; Myocardium; Myosin Heavy Chains; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; RNA, Messenger; Systole; Tenascin; Time Factors; Ventricular Dysfunction, Left; Ventricular Pressure | 2009 |
Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of Kv1.5 channels in rats.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Hypertension, Pulmonary; Kv1.5 Potassium Channel; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Time Factors; Up-Regulation | 2009 |
Nanoparticle-mediated delivery of nuclear factor kappaB decoy into lungs ameliorates monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Drug Delivery Systems; Humans; Hypertension, Pulmonary; Monocrotaline; Nanoparticles; NF-kappa B; Oligodeoxyribonucleotides; Rats | 2009 |
Cirrhosis ameliorates monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Common Bile Duct; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Hypertension, Pulmonary; Ligation; Liver Cirrhosis, Biliary; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasodilation | 2009 |
Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats.
Topics: Adrenomedullin; Animals; Genetic Therapy; Hemodynamics; Hypertension, Pulmonary; Male; Mice; Mice, Inbred ICR; Micelles; Monocrotaline; Nanostructures; Polymers; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension.
Topics: Angiotensin I; Animals; Antihypertensive Agents; Apelin; Apelin Receptors; Carrier Proteins; Endothelin-1; Gene Expression Profiling; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intercellular Signaling Peptides and Proteins; Male; Monocrotaline; Myocardium; Peptide Fragments; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; RNA, Messenger; Ventricular Function, Right | 2009 |
Preventive effects of raloxifene, a selective estrogen receptor modulator, on monocrotaline-induced pulmonary hypertension in intact and ovariectomized female rats.
Topics: Animals; Blood Pressure; Body Weight; Endothelin-1; Female; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Organ Size; Ovariectomy; Pulmonary Artery; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Substrate Specificity; Time Factors; Ventricular Dysfunction, Right | 2009 |
Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in rats.
Topics: Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rats; Rats, Wistar | 2009 |
Discriminating pulmonary hypertension caused by monocrotaline toxicity from chronic hypoxia by near-infrared spectroscopy and multivariate methods of analysis.
Topics: Animals; Chronic Disease; Hypertension, Pulmonary; Hypoxia; Least-Squares Analysis; Lung; Monocrotaline; Multivariate Analysis; Rats; Rats, Sprague-Dawley; Spectroscopy, Near-Infrared | 2009 |
Pulmonary hypertension modifies responsiveness of sinoatrial cells of rat hearts to adrenomimetics and activators of ATP-sensitive K+ channels in a gender-dependent way.
Topics: Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Chromans; Disease Models, Animal; Female; Guinea Pigs; Heart Rate; Hypertension, Pulmonary; Isoproterenol; KATP Channels; Male; Monocrotaline; Pyrrolidines; Rats; Sex Factors; Sinoatrial Node; Tumor Necrosis Factor-alpha | 2009 |
The effects and mechanisms of mycophenolate mofetil on pulmonary arterial hypertension in rats.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypertrophy; Immunosuppressive Agents; Male; Monocrotaline; Muscle, Smooth, Vascular; Mycophenolic Acid; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2010 |
Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats.
Topics: Animals; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Secondary Prevention; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Time Factors | 2009 |
Change in pharmacological effect of endothelin receptor antagonists in rats with pulmonary hypertension: role of ETB-receptor expression levels.
Topics: Animals; Basilar Artery; Blotting, Western; Endothelin B Receptor Antagonists; Endothelin-1; Fluorescent Antibody Technique; Hypertension, Pulmonary; Male; Microscopy, Confocal; Monocrotaline; Poisons; Pulmonary Artery; Pulmonary Veins; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Vascular Resistance | 2009 |
Molecular imaging of monocrotaline-induced pulmonary vascular disease with radiolabeled linear adrenomedullin.
Topics: Adrenomedullin; Animals; Hypertension, Pulmonary; Isotope Labeling; Lung; Male; Metabolic Clearance Rate; Monocrotaline; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Technetium; Tissue Distribution | 2009 |
Early combined treatment with cilostazol and bone marrow-derived endothelial progenitor cells markedly attenuates pulmonary arterial hypertension in rats.
Topics: Animals; Bone Marrow Transplantation; Cilostazol; Combined Modality Therapy; Endothelial Cells; Fluorescent Dyes; Hematopoietic Stem Cell Transplantation; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Membrane Proteins; Monocrotaline; Myocardium; Phenotype; Poisons; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles; Vasodilator Agents | 2009 |
Opposite effects of training in rats with stable and progressive pulmonary hypertension.
Topics: Adaptation, Physiological; Animals; Biopsy; Capillaries; Cardiac Catheterization; Cardiac Output; Coronary Circulation; Disease Models, Animal; Disease Progression; Echocardiography; Heart Failure; Hypertension, Pulmonary; Male; Monocrotaline; Myocarditis; Physical Conditioning, Animal; Physical Endurance; Rats; Rats, Wistar; Rest; Survival Rate | 2009 |
Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme 2; Animals; Disease Models, Animal; Gene Transfer Techniques; Hypertension, Pulmonary; Infusions, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Peptidyl-Dipeptidase A; Probability; Random Allocation; Renin-Angiotensin System; RNA, Messenger; Sensitivity and Specificity | 2009 |
[Simvastatin prevents the development of pulmonary hypertension in the rats through reduction of inflammation].
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Hypertension, Pulmonary; Interleukin-6; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Necrosis Factor-alpha | 2009 |
Is resveratrol the magic bullet for pulmonary hypertension?
Topics: Animals; Blood Pressure; Cell Proliferation; Dose-Response Relationship, Drug; Endothelium, Vascular; Gene Expression; Hypertension, Pulmonary; Models, Biological; Monocrotaline; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Pulmonary Artery; Rats; Resveratrol; Stilbenes; Tumor Necrosis Factors; Vasodilation; Vasodilator Agents | 2009 |
Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Blood Pressure; Blotting, Western; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Gene Expression; Hypertension, Pulmonary; Interleukin-6; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Stilbenes; Tumor Necrosis Factors; Vasodilation; Vasodilator Agents | 2009 |
Propylthiouracil attenuates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Antihypertensive Agents; Arterioles; Caspase 3; Connexin 43; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Matrix Metalloproteinase 9; Monocrotaline; Nitric Oxide Synthase Type III; Propylthiouracil; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha; Ventricular Function, Right; Ventricular Pressure | 2009 |
Syngeneic bone marrow mononuclear cells improve pulmonary arterial hypertension through vascular endothelial growth factor upregulation.
Topics: Animals; Bone Marrow Transplantation; Cells, Cultured; Disease Models, Animal; Female; Genetic Therapy; Hypertension, Pulmonary; Immunohistochemistry; Mice; Mice, Inbred C57BL; Monocrotaline; Monocytes; Receptors, Vascular Endothelial Growth Factor; Transplantation, Isogeneic; Up-Regulation; Vascular Endothelial Growth Factors | 2009 |
Senescent endothelial progenitor cells from dogs with pulmonary arterial hypertension: a before-after self-controlled study.
Topics: Animals; Cell Culture Techniques; Cell Separation; Cells, Cultured; Cellular Senescence; Disease Models, Animal; Dogs; Endothelial Cells; Endothelium, Vascular; Flow Cytometry; Hypertension, Pulmonary; Male; Monocrotaline; Neovascularization, Physiologic; Stem Cells | 2009 |
Establishment of rat model of cardiopulmonary bypass in pulmonary hypertension.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Cardiopulmonary Bypass; Disease Models, Animal; Hematocrit; Hypertension, Pulmonary; Interleukin-6; Male; Monocrotaline; Oxygen; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha | 2009 |
Alterations in pharmacological action of the right ventricle of monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Body Weight; Cardiotonic Agents; Disease Models, Animal; Electrocardiography; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Myocardial Contraction; Organ Size; Perfusion; Rats; Rats, Wistar; Ventricular Function, Right | 2009 |
Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Blotting, Western; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; Monocrotaline; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, TIE-2; Vascular Endothelial Growth Factor A | 2009 |
Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart.
Topics: Animals; Cardiac Pacing, Artificial; Chronic Disease; Disease Models, Animal; Heart Failure; Heart Septum; Hypertension, Pulmonary; In Vitro Techniques; Magnetic Resonance Imaging; Male; Monocrotaline; Myocardial Contraction; Perfusion; Rats; Reproducibility of Results; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Left; Ventricular Function, Right; Ventricular Pressure | 2009 |
Progesterone inhibits vascular remodeling and attenuates monocrotaline-induced pulmonary hypertension in estrogen-deficient rats.
Topics: Animals; Female; Hypertension, Pulmonary; Monocrotaline; Ovariectomy; Progesterone; Progestins; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Ventricular Function, Right | 2009 |
Possible involvement of mitochondrial energy-producing ability in the development of right ventricular failure in monocrotaline-induced pulmonary hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Cardiomyopathy, Dilated; Heart; Heart Failure; Hemodynamics; Hypertension, Pulmonary; Male; Mitochondria, Heart; Monocrotaline; Myocardium; Organ Size; Oxygen Consumption; Phosphocreatine; Random Allocation; Rats; Rats, Wistar; Ultrasonography | 2009 |
Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.
Topics: Animals; Arterioles; Cardiac Output; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Extracellular Matrix Proteins; Female; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Lung; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Myocardial Contraction; Myocardium; Pulmonary Alveoli; Pulmonary Artery; Rats; Rats, Wistar; Recovery of Function; RNA, Messenger; Stroke Volume; Time Factors; Transplantation, Homologous; Vascular Endothelial Growth Factor A; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2009 |
Effects of telmisartan on right ventricular remodeling induced by monocrotaline in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Body Weight; Echocardiography; Fibrosis; Histocytochemistry; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocardium; Organ Size; Rats; Rats, Wistar; Stroke Volume; Systole; Telmisartan; Transforming Growth Factor beta1; Ventricular Remodeling | 2009 |
Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Propanolamines; Rats; Rats, Wistar; Sympathetic Nervous System; Ventricular Pressure | 2009 |
Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats.
Topics: Animals; Blood Pressure; Blotting, Western; Cell Proliferation; Disease Models, Animal; Down-Regulation; GATA6 Transcription Factor; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Time Factors | 2009 |
Tadalafil, a long-acting inhibitor of PDE5, improves pulmonary hemodynamics and survival rate of monocrotaline-induced pulmonary artery hypertension in rats.
Topics: Animals; Blood Gas Analysis; Carbolines; Cyclic GMP; Disease Progression; Dose-Response Relationship, Drug; Hemodynamics; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Organ Size; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Poisons; Pulmonary Circulation; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Survival; Tadalafil | 2009 |
Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mesenteric Arteries; Monocrotaline; Myocardium; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2010 |
The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension.
Topics: Animals; Disease Progression; Glucuronosyltransferase; Hyaluronan Synthases; Hyaluronic Acid; Hyaluronoglucosaminidase; Hypertension, Pulmonary; Lung; Male; Molecular Weight; Monocrotaline; Rats; Rats, Inbred F344 | 2010 |
Innate immunity in the therapeutic actions of endothelial progenitor cells in pulmonary hypertension.
Topics: Animals; Biomarkers; Blood Pressure; Cell Death; Cells, Cultured; Coculture Techniques; Dendritic Cells; Disease Models, Animal; Endothelial Cells; Flow Cytometry; Humans; Hypertension, Pulmonary; Immunity, Innate; Killer Cells, Natural; Lung; Monocrotaline; Monocytes; Rats; Rats, Nude; Spleen; Stem Cells | 2010 |
Pulmonary hemodynamic response to acute combination and monotherapy with sildenafil and brain natriuretic peptide in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Drug Therapy, Combination; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Natriuretic Peptide, Brain; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Time Factors | 2010 |
Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation.
Topics: Administration, Inhalation; Animals; Cell Division; Cells, Cultured; Chronic Disease; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocrotaline; Myocytes, Smooth Muscle; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sodium Nitrite; Xanthine Dehydrogenase | 2010 |
Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure.
Topics: Animals; Antioxidants; Disease Models, Animal; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Organometallic Compounds; Rats; Rats, Wistar; Reactive Oxygen Species; Salicylates; Ventricular Dysfunction, Right; Ventricular Remodeling | 2010 |
The extracellular signal-regulated kinase is involved in the effects of sildenafil on pulmonary vascular remodeling.
Topics: Actins; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Dual Specificity Phosphatase 1; Fluorescent Antibody Technique; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocrotaline; Phosphorylation; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sildenafil Citrate; Sulfones; Vasodilator Agents | 2010 |
Pulmonary hypertension is ameliorated in mice deficient in thrombin-activatable fibrinolysis inhibitor.
Topics: Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Capillary Permeability; Carboxypeptidase B2; Chemokine CCL2; Disease Models, Animal; Fibrinolysis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocrotaline; Platelet-Derived Growth Factor; Pulmonary Artery; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Weight Loss | 2010 |
Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelial Cells; Fibroblasts; Gene Expression Profiling; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Male; MicroRNAs; Monocrotaline; Muscle, Smooth, Vascular; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Ribonuclease III; Time Factors | 2010 |
Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Bone Morphogenetic Protein Receptors, Type II; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endothelial Cells; Gene Transfer Techniques; Genetic Therapy; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-10; Interleukin-6; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Survival Analysis; Tissue Extracts; Transforming Growth Factor beta | 2010 |
Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes.
Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy; Male; Monocrotaline; Muscle Relaxation; Myocardial Contraction; Myocytes, Cardiac; Oxygen; Papillary Muscles; Rats; Rats, Wistar | 2010 |
Progressive endothelial cell damage in an inflammatory model of pulmonary hypertension.
Topics: Animals; Cytosol; Disease Progression; Endothelial Cells; Gene Expression; Hypertension, Pulmonary; Inflammation; Male; Membrane Proteins; Monocrotaline; Nitric Oxide; Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 2010 |
A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat model.
Topics: Analysis of Variance; Animals; Blood Flow Velocity; Cardiac Catheterization; Disease Models, Animal; Echocardiography, Doppler; Female; Hypertension, Pulmonary; Monocrotaline; Predictive Value of Tests; Rats; Rats, Nude; ROC Curve; Sensitivity and Specificity; Tricuspid Valve Insufficiency; Vascular Resistance | 2010 |
[TRPC6 mediates the enhancements of pulmonary arterial tone and intracellular Ca2+ concentration of pulmonary arterial smooth muscle cells in pulmonary hypertension rats].
Topics: Animals; Calcium; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; TRPC Cation Channels | 2010 |
Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Anticholesteremic Agents; Disease Models, Animal; Drug Therapy, Combination; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Simvastatin; Sulfones | 2010 |
L-arginine restores endothelial nitric oxide synthase-coupled activity and attenuates monocrotaline-induced pulmonary artery hypertension in rats.
Topics: Animals; Arginine; Blood Pressure; Blotting, Western; Body Weight; HSP90 Heat-Shock Proteins; Hypertension, Pulmonary; Immunoprecipitation; Kaplan-Meier Estimate; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2010 |
Sildenafil limits monocrotaline-induced pulmonary hypertension in rats through suppression of pulmonary vascular remodeling.
Topics: Animals; Arterioles; Blood Vessels; Caspase 3; Connexin 43; Hypertension; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Piperazines; Purines; Random Allocation; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Tumor Necrosis Factor-alpha; Ventricular Myosins | 2010 |
KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel.
Topics: Animals; Blotting, Western; Calcium; Chronic Disease; Female; Hypertension, Pulmonary; Monocrotaline; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Piperidines; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Up-Regulation; Xanthines | 2010 |
Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Familial Primary Pulmonary Hypertension; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Piperazines; Pulmonary Artery; Purines; Rats; Sildenafil Citrate; Sulfonamides; Sulfones; Vasodilator Agents | 2010 |
Downregulation of oxytocin receptors in right ventricle of rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blotting, Western; Down-Regulation; Gene Expression; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats.
Topics: Animals; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Magnetic Resonance Imaging; Male; Monocrotaline; Myocardium; Organ Size; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Antagonists; Thiophenes | 2010 |
Analysis of responses to the Rho-kinase inhibitor Y-27632 in the pulmonary and systemic vascular bed of the rat.
Topics: Amides; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Injections, Intravenous; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; rho-Associated Kinases; Soluble Guanylyl Cyclase; Time Factors; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2010 |
Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.
Topics: Animals; Antihypertensive Agents; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epoprostenol; Humans; Hypertension, Pulmonary; Iloprost; Inhibitor of Differentiation Protein 1; Male; Monocrotaline; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Phosphorylation; Promoter Regions, Genetic; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Interference; Smad Proteins; Smad1 Protein; Smad5 Protein; Smad6 Protein; Transfection; Up-Regulation | 2010 |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Electrocardiography; Entropy; Heart Rate; Hypertension, Pulmonary; Injections, Subcutaneous; Ketamine; Monocrotaline; Rats; Rats, Wistar; Time Factors | 2010 |
Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension.
Topics: Animals; Blotting, Western; Bone Morphogenetic Protein Receptors; Disease Models, Animal; Down-Regulation; Enzyme Induction; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Smad7 Protein; Ubiquitin-Protein Ligases; Ubiquitination | 2010 |
Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiac Catheterization; Cardiac Output; Catheterization; Echocardiography; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Magnetic Resonance Imaging; Male; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Thermodilution | 2010 |
A high-calorie diet attenuates cachexia and adipose tissue inflammation in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Cachexia; Energy Intake; Hypertension, Pulmonary; Male; Monocrotaline; Panniculitis; Rats; Rats, Wistar | 2010 |
Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents; Bone Morphogenetic Protein Receptors; Cell Proliferation; Dexamethasone; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Immunohistochemistry; Interleukin-6; Lung; Male; Monocrotaline; Muscle, Smooth; Rats; Rats, Wistar; Treatment Outcome | 2011 |
Dose-dependent therapeutic effects of 2-Methoxyestradiol on Monocrotaline-Induced pulmonary hypertension and vascular remodelling.
Topics: 2-Methoxyestradiol; Animals; Dose-Response Relationship, Drug; Estradiol; Hypertension, Pulmonary; Male; Monocrotaline; Rats, Sprague-Dawley; Tubulin Modulators; Vascular Remodeling | 2010 |
Effects of atorvastatin and L-arginine treatments on electrical field stimulation-mediated relaxations in pulmonary arterial rings of monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Arginine; Atorvastatin; Electric Stimulation; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilation | 2010 |
The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats.
Topics: Animals; Atorvastatin; COP9 Signalosome Complex; Gene Expression Regulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Intracellular Signaling Peptides and Proteins; Male; Monocrotaline; p38 Mitogen-Activated Protein Kinases; Pneumonectomy; Proliferating Cell Nuclear Antigen; Proteins; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar | 2010 |
Synergistic therapeutic effects of 2-methoxyestradiol with either sildenafil or bosentan on amelioration of monocrotaline-induced pulmonary hypertension and vascular remodeling.
Topics: 2-Methoxyestradiol; Animals; Antihypertensive Agents; Bosentan; Drug Synergism; Drug Therapy, Combination; Estradiol; Female; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfonamides; Sulfones; Vasodilator Agents | 2010 |
Systemic evaluation of platelet and leukocyte activation and interaction in a rat model of pulmonary arterial hypertension.
Topics: Animals; Cell Communication; Disease Models, Animal; Flow Cytometry; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Leukocytes; Male; Monocrotaline; Platelet Activation; Rats; Rats, Sprague-Dawley | 2010 |
Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.
Topics: Adult; Animals; Cell Proliferation; Cells, Cultured; Dopamine Agonists; Female; Humans; Hypertension, Pulmonary; Lisuride; Lung; Lung Transplantation; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Serotonin 5-HT2 Receptor Antagonists | 2011 |
Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.
Topics: Animals; Animals, Newborn; Antiretroviral Therapy, Highly Active; Antiviral Agents; Blood Pressure; Carbamates; Cell Division; Furans; Hemodynamics; HIV Protease Inhibitors; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Nelfinavir; Pulmonary Artery; Rats; Rats, Wistar; Ritonavir; Sulfonamides | 2010 |
Rapid quantification of myocardial fibrosis: A new macro-based automated analysis.
Topics: Aged; Animals; Automation, Laboratory; Azo Compounds; Cardiomyopathies; Coloring Agents; Disease Models, Animal; Fibrosis; Humans; Hypertension, Pulmonary; Image Interpretation, Computer-Assisted; Male; Microscopy, Polarization; Monocrotaline; Myocardium; Rats; Rats, Wistar | 2010 |
Transgenic expression of human matrix metalloproteinase-9 augments monocrotaline-induced pulmonary arterial hypertension in mice.
Topics: Actins; Animals; Antigens, Differentiation; Base Sequence; Blood Pressure; Disease Models, Animal; DNA Primers; Gene Expression; Humans; Hypertension, Pulmonary; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Monocrotaline; Recombinant Proteins; RNA, Messenger | 2011 |
Effects of simvastatin on pulmonary C-fiber sensitivity in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Heme Oxygenase (Decyclizing); Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Nerve Fibers, Unmyelinated; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Simvastatin | 2011 |
Effects of atorvastatin and losartan on monocrotaline-induced pulmonary artery remodeling in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Atorvastatin; Base Sequence; Calcium Channels, L-Type; Disease Models, Animal; DNA Primers; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Inositol 1,4,5-Trisphosphate Receptors; Losartan; Male; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2010 |
Suppression of tissue inhibitors of metalloproteinases may reverse severe pulmonary arterial hypertension.
Topics: Animals; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Matrix Metalloproteinases; Monocrotaline; RNA, Small Interfering; Tissue Inhibitor of Metalloproteinases | 2011 |
Mast cells promote lung vascular remodelling in pulmonary hypertension.
Topics: Animals; Gene Expression Profiling; Histamine H1 Antagonists; Hypertension, Pulmonary; Ketotifen; Lung; Male; Mast Cells; Monocrotaline; Rats; Rats, Sprague-Dawley; Up-Regulation; Ventricular Dysfunction, Left | 2011 |
Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Angiography; Animals; Endothelium, Vascular; Enzyme Inhibitors; Hypertension, Pulmonary; Lung; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitroprusside; Rats; Rats, Sprague-Dawley; Regional Blood Flow; rho-Associated Kinases; Signal Transduction; Vasoconstriction; Vasodilator Agents | 2011 |
Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzoates; Biphenyl Compounds; Guanylate Cyclase; Heme; Hydrocarbons, Fluorinated; Hypertension, Pulmonary; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2011 |
Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats.
Topics: Animals; Cytokines; Disease Models, Animal; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fluoxetine; Hypertension, Pulmonary; Inflammation; Lung; Male; Matrix Metalloproteinase Inhibitors; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Tissue Inhibitor of Metalloproteinases | 2011 |
Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension.
Topics: Animals; Cell Line; Cell Proliferation; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Drug Delivery Systems; Fluorescein-5-isothiocyanate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Kaplan-Meier Estimate; Lung; Male; Microscopy, Fluorescence; Monocrotaline; Myocytes, Smooth Muscle; Nanoparticles; NF-kappa B; Nitric Oxide Synthase; Pulmonary Artery; Quinolines; Rats; Rats, Sprague-Dawley; Remission Induction | 2011 |
Hepatocyte growth factor improves the survival of rats with pulmonary arterial hypertension via the amelioration of pulmonary hemodynamics.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; C-Reactive Protein; Constriction, Pathologic; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Hemodynamics; Hepatocyte Growth Factor; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Platelet-Derived Growth Factor; Pulmonary Artery; Rats; Rats, Wistar; Recombinant Proteins; Survival Analysis | 2011 |
Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels.
Topics: Animals; Aspirin; Blood Pressure; Body Weight; Disease Models, Animal; Heart Rate; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Serotonin; Survival Analysis | 2011 |
Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Biomarkers; Blood Pressure; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Male; Malondialdehyde; Monocrotaline; Rats; Rats, Sprague-Dawley; Sodium Chloride; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Ang-(1-7) might prevent the development of monocrotaline induced pulmonary arterial hypertension in rats.
Topics: Angiotensin I; Animals; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type III; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley | 2011 |
Urantide alleviates monocrotaline induced pulmonary arterial hypertension in Wistar rats.
Topics: Animals; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Organ Size; Peptide Fragments; Pulmonary Artery; Rats; Rats, Wistar; Urotensins; Vasodilation | 2011 |
Treatment of pulmonary arterial hypertension with circulating angiogenic cells.
Topics: Animals; Arteries; Cell Movement; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kaplan-Meier Estimate; Monocrotaline; Rats; Rats, Nude; Stem Cell Transplantation; Stem Cells; Ventricular Remodeling | 2011 |
Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium Channels; Computer Simulation; Disease Models, Animal; Electric Stimulation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Potassium Channels; Rats; Rats, Wistar; Stroke Volume; Tachycardia, Ventricular | 2011 |
Doppler flow spectra of the superior vena cava in a rat model of chronic pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Echocardiography, Doppler; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Rats; Rats, Sprague-Dawley; Systole; Vena Cava, Superior | 2011 |
Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension.
Topics: Analysis of Variance; Animals; Blood Pressure; Blotting, Western; Connexin 43; Connexins; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Fluorescent Antibody Technique; Gap Junction alpha-4 Protein; Gap Junction alpha-5 Protein; Gap Junctions; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Muscle, Smooth, Vascular; Phenylephrine; Pulmonary Artery; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Serotonin; Vasoconstriction; Vasoconstrictor Agents | 2011 |
Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Dexamethasone; Familial Primary Pulmonary Hypertension; Glucocorticoids; Hypertension, Pulmonary; Interferon-gamma; Interleukin-4; Lung; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar; Receptors, Chemokine | 2011 |
Acceleration of Ca2+ waves in monocrotaline-induced right ventricular hypertrophy in the rat.
Topics: Animals; Arrhythmias, Cardiac; Calcium Signaling; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kinetics; Membrane Potentials; Monocrotaline; Myocardial Contraction; Myocardium; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Ventricular Function, Right; Ventricular Pressure | 2011 |
[A sharp increase in the density of pulmonary and pericardial mast cells under monocrotaline-induced pulmonary hypertension in rats].
Topics: Alcian Blue; Animals; Cell Count; Cell Movement; Echocardiography; Hypertension, Pulmonary; Lung; Male; Mast Cells; Microtomy; Monocrotaline; Myocardium; Organ Size; Paraffin Embedding; Pericardium; Phenazines; Pulmonary Artery; Rats; Rats, Wistar | 2011 |
Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling.
Topics: Animals; Cell Proliferation; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic Nucleotide Phosphodiesterases, Type 7; Gene Expression Regulation, Enzymologic; Gene Knockdown Techniques; Humans; Hypertension, Pulmonary; Intracellular Space; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Papaverine; Phosphoric Diester Hydrolases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Tissue Donors; Up-Regulation | 2011 |
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Cell Degranulation; Cromolyn Sodium; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mast Cells; Monocrotaline; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Rats; Rats, Sprague-Dawley; Ventricular Function, Right; Ventricular Remodeling | 2011 |
Rapid quantification of myocardial fibrosis: a new macro-based automated analysis.
Topics: Animals; Automation; Azo Compounds; Body Weight; Electrocardiography; Fibrosis; Hemodynamics; Humans; Hypertension, Pulmonary; Image Processing, Computer-Assisted; Microscopy, Polarization; Monocrotaline; Myocardium; Organ Size; Paraffin Embedding; Rats; Rats, Wistar; Time Factors; Ultrasonography | 2011 |
Peptide-directed highly selective targeting of pulmonary arterial hypertension.
Topics: Amino Acid Sequence; Animals; Drug Delivery Systems; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Molecular Sequence Data; Monocrotaline; Peptides; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Time Factors | 2011 |
[Effects of rosuvastatin on monocrotaline-induced pulmonary artery hypertension in rats].
Topics: Animals; Cell Proliferation; Endothelial Cells; Familial Primary Pulmonary Hypertension; Fluorobenzenes; Hypertension, Pulmonary; Hypolipidemic Agents; Male; Monocrotaline; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type III; Proliferating Cell Nuclear Antigen; Pyrimidines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Rosuvastatin Calcium; Sulfonamides | 2011 |
Involvement of BMPR2 in the protective effect of fluoxetine against monocrotaline-induced endothelial apoptosis in rats.
Topics: Animals; Apoptosis; beta Catenin; Blood Pressure; Bone Morphogenetic Protein Receptors, Type II; Caspase 3; Cyclic GMP-Dependent Protein Kinases; Endothelial Cells; Fluoxetine; Gene Expression; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Microvessels; Monocrotaline; Phosphorylation; Pulmonary Artery; Rats; Rats, Wistar; Smad1 Protein | 2011 |
Rosuvastatin attenuates monocrotaline-induced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism.
Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Body Weight; Fluorobenzenes; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Organ Size; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-akt; Pyrimidines; Rats; Rats, Sprague-Dawley; Rosuvastatin Calcium; Signal Transduction; Sulfonamides; Ventricular Dysfunction, Right | 2011 |
Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: 4-Aminobenzoic Acid; Animals; Body Weight; Cardiomegaly; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; para-Aminobenzoates; Pulmonary Artery; Rats; Rats, Wistar; Survival Analysis | 2011 |
A role for coagulation factor Xa in experimental pulmonary arterial hypertension.
Topics: Animals; Blood Coagulation; Enoxaparin; Factor Xa; Factor Xa Inhibitors; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Morpholines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Rivaroxaban; Thiophenes; Thrombosis; Warfarin | 2011 |
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Disease Models, Animal; Echocardiography, Doppler; Endothelin A Receptor Antagonists; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoxazoles; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfones; Time Factors; Ventricular Function, Right; Ventricular Remodeling | 2011 |
Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase.
Topics: Animals; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Mice; Mice, Knockout; Monocrotaline; Mutation; Rats; Superoxide Dismutase | 2011 |
Intralipid prevents and rescues fatal pulmonary arterial hypertension and right ventricular failure in rats.
Topics: Actins; Animals; Apoptosis; Blotting, Western; Caspase 3; Emulsions; Fat Emulsions, Intravenous; Fibrosis; Heart; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Microscopy, Confocal; Monocrotaline; Myocardium; Phospholipids; Platelet Endothelial Cell Adhesion Molecule-1; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Soybean Oil; Vascular Endothelial Growth Factor A | 2011 |
Transgenic expression of human matrix metalloproteinase-1 attenuates pulmonary arterial hypertension in mice.
Topics: Actins; Animals; Antigens, Differentiation; Cell Proliferation; Collagen; Disease Models, Animal; Humans; Hyperplasia; Hypertension, Pulmonary; Macrophages; Matrix Metalloproteinase 1; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Up-Regulation | 2012 |
Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension.
Topics: Animals; Etanercept; Familial Primary Pulmonary Hypertension; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypertension, Pulmonary; Immunoglobulin G; Inflammation Mediators; Ion Channel Gating; Ketone Oxidoreductases; Kv1.5 Potassium Channel; Models, Biological; Monocrotaline; Myocytes, Smooth Muscle; Phenotype; Pulmonary Artery; Rats; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2011 |
Effects of everolimus in combination with sildenafil in monocrotaline-induced pulmonary hypertension in rats.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelin-1; Everolimus; Female; Hypertension, Pulmonary; Monocrotaline; Nitroprusside; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sirolimus; Sulfones; Vasoconstrictor Agents; Vasodilator Agents; Ventricular Dysfunction, Right; Ventricular Remodeling | 2012 |
Alteration of pulmonary artery integrin levels in chronic hypoxia and monocrotaline-induced pulmonary hypertension.
Topics: Animals; Calcium Signaling; Chronic Disease; Disease Models, Animal; Focal Adhesion Kinase 1; Hypertension, Pulmonary; Hypoxia; Integrins; Male; Monocrotaline; Muscle, Smooth, Vascular; Phosphorylation; Pulmonary Artery; Rats; Rats, Wistar | 2011 |
Pulmonary oxidative stress is increased in cyclooxygenase-2 knockdown mice with mild pulmonary hypertension induced by monocrotaline.
Topics: Animals; Cyclooxygenase 2; Female; Hypertension, Pulmonary; Male; Mice; Mice, Knockout; Monocrotaline; Oxidative Stress | 2011 |
Simvastatin protects against the development of monocrotaline-induced pulmonary hypertension in rats via a heme oxygenase-1-dependent pathway.
Topics: Animals; Arterioles; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-6; Lung; Monocrotaline; Protoporphyrins; Rats; Rats, Sprague-Dawley; Signal Transduction; Simvastatin | 2011 |
Implantation of mesenchymal stem cells improves right ventricular impairments caused by experimental pulmonary hypertension.
Topics: Animals; Bone Marrow Cells; Hemodynamics; Hypertension, Pulmonary; Injections, Subcutaneous; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right | 2012 |
Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension.
Topics: Adult; Animals; Antihypertensive Agents; Apoptosis; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II; Calcium; Cell Proliferation; Cells, Cultured; Dehydroepiandrosterone; Disease Models, Animal; Enzyme Activation; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; In Situ Nick-End Labeling; Inhibitor of Apoptosis Proteins; Male; Membrane Potential, Mitochondrial; MicroRNAs; Microtubule-Associated Proteins; Middle Aged; Monocrotaline; Muscle, Smooth; Myocytes, Smooth Muscle; NFATC Transcription Factors; Proto-Oncogene Proteins c-pim-1; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Survivin; Vasodilator Agents | 2011 |
C-122, a novel antagonist of serotonin receptor 5-HT2B, prevents monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterioles; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood Proteins; Familial Primary Pulmonary Hypertension; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Male; Monocrotaline; Phenothiazines; Piperazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Serotonin 5-HT2 Receptor Antagonists | 2011 |
Association of the time course of pulmonary arterial hypertension with changes in oxidative stress in the left ventricle.
Topics: Animals; Ascorbic Acid; Cardiomegaly; Familial Primary Pulmonary Hypertension; Glutathione; Heart Ventricles; Hydrogen Peroxide; Hypertension, Pulmonary; Male; Monocrotaline; Oxidative Stress; Rats; Rats, Wistar; Thioredoxin-Disulfide Reductase; Ultrasonography | 2011 |
Egr-1 expression during neointimal development in flow-associated pulmonary hypertension.
Topics: Animals; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Early Growth Response Protein 1; Familial Primary Pulmonary Hypertension; Heart Defects, Congenital; Hemodynamics; Humans; Hypertension, Pulmonary; Immunohistochemistry; Monocrotaline; Neointima; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Repressor Proteins | 2011 |
Enhanced store-operated Ca²+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Hypertension, Pulmonary; Male; Monocrotaline; Organ Culture Techniques; Pulmonary Artery; Rats; Rats, Sprague-Dawley; TRPC Cation Channels | 2012 |
Mast cell inhibition improves pulmonary vascular remodeling in pulmonary hypertension.
Topics: Animals; Cell Proliferation; Chymases; Cromolyn Sodium; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Mast Cells; Monocrotaline; Muscle, Smooth, Vascular; Neovascularization, Pathologic; Rats; Rats, Wistar; Sulfonamides; Thiophenes | 2012 |
Evidence of diminished coronary flow in pulmonary hypertension: explaining angina pectoris in this patient group?
Topics: Angina Pectoris; Animals; Blood Flow Velocity; Blood Pressure; Cardiac Catheterization; Cardiac Output; Coronary Circulation; Dilatation, Pathologic; Disease Models, Animal; Echocardiography, Doppler; Female; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Nude; Time Factors; Ventricular Function, Left | 2011 |
Development and characterization of an animal model of severe pulmonary arterial hypertension.
Topics: Animals; Chronic Disease; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Rats; Rats, Wistar; Tunica Media | 2012 |
Influence of estrogen on pulmonary arterial hypertension: role of oxidative stress.
Topics: Animals; Blotting, Western; Body Weight; Diestrus; Estradiol; Female; Glutathione; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Ovariectomy; Oxidative Stress; Plant Oils; Pulmonary Artery; Rats; Rats, Wistar; Sunflower Oil | 2011 |
VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension.
Topics: Animals; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Monocrotaline; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Sulfonamides; Vasoactive Intestinal Peptide | 2011 |
Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antihypertensive Agents; Bisoprolol; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Echocardiography; Fibrosis; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Wistar; Signal Transduction; Vascular Resistance | 2012 |
Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.
Topics: Animals; Calcium; Disease Models, Animal; Excitation Contraction Coupling; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microscopy, Confocal; Monocrotaline; Myocardial Contraction; Myocytes, Cardiac; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Treatment Outcome; Ventricular Dysfunction, Right; Ventricular Remodeling | 2012 |
Dysregulation of PTEN in cardiopulmonary vascular remodeling induced by pulmonary hypertension.
Topics: Animals; Cell Cycle Proteins; Cell Proliferation; Gene Expression Regulation; Heart; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Monocrotaline; Myocardium; Myocytes, Smooth Muscle; Proteasome Endopeptidase Complex; Proteolysis; PTEN Phosphohydrolase; Rats | 2013 |
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.
Topics: Animals; Case-Control Studies; Caveolin 1; CD47 Antigen; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocrotaline; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Thrombospondin 1; Up-Regulation | 2012 |
Attenuation of the extract from Moringa oleifera on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Drug Evaluation, Preclinical; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Moringa oleifera; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase | 2012 |
Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline.
Topics: Animals; Blotting, Western; Cell Adhesion Molecules; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; I-kappa B Proteins; Inflammation; Male; Mice; Monocrotaline; Myocardium; NF-kappa B; NF-KappaB Inhibitor alpha; Poisons; Real-Time Polymerase Chain Reaction; RNA; Signal Transduction; Ventricular Remodeling | 2012 |
Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension.
Topics: Acetylcholine; Acidosis, Respiratory; Airway Remodeling; Ammonium Chloride; Animals; Antihypertensive Agents; Blood Pressure; Carbon Dioxide; Cholinergic Agonists; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Hypoxia; In Vitro Techniques; Lung; Male; Monocrotaline; Nitroprusside; Organ Size; Phenylephrine; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents | 2012 |
Effects of autologous bone marrow mononuclear cells implantation in canine model of pulmonary hypertension.
Topics: Animals; Bone Marrow Transplantation; Cell Differentiation; Cell Separation; Cell Tracking; Disease Models, Animal; Dogs; Endothelial Cells; Endothelin-1; Flow Cytometry; Fluorescent Antibody Technique; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-6; Monocrotaline; Neovascularization, Physiologic; Pulmonary Artery; RNA, Messenger; Stem Cell Transplantation; Time Factors; Transplantation, Autologous; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Ventricular Function, Right | 2012 |
Monocrotaline-induced pulmonary hypertension in Wistar rats.
Topics: Animals; Antihypertensive Agents; Cardiac Output; Carotid Arteries; Catheterization, Swan-Ganz; Disease Models, Animal; Femoral Artery; Femoral Vein; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Wedge Pressure; Rats; Rats, Wistar | 2009 |
Cardiac and vascular atrogin-1 mRNA expression is not associated with dexamethasone efficacy in the monocrotaline model of pulmonary hypertension.
Topics: Animals; Blood Pressure; Dexamethasone; Disease Models, Animal; Drug Antagonism; Gene Expression; Glucocorticoids; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle Proteins; Myostatin; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; SKP Cullin F-Box Protein Ligases | 2012 |
[Determination of pulmonary vascular resistance by improved right heart catheter in rat].
Topics: Animals; Cardiac Catheters; Hypertension, Pulmonary; Monocrotaline; Rats; Rats, Sprague-Dawley; Vascular Resistance | 2011 |
[Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by up-regulating heme oxygenase-1 expression].
Topics: Animals; Genistein; Heme Oxygenase (Decyclizing); Hypertension, Pulmonary; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Up-Regulation | 2012 |
Treatment with LA-419 prevents monocrotaline-induced pulmonary hypertension and lung injury in the rat.
Topics: Animals; Blood Pressure; Hypertension, Pulmonary; Isosorbide Dinitrate; Male; Monocrotaline; Nitric Oxide Donors; Rats; Rats, Wistar | 2011 |
Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Morpholines; Nitric Oxide; Nitroprusside; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium Nitrite; Tunica Media | 2012 |
Effects of purple grape juice in the redox-sensitive modulation of right ventricular remodeling in a pulmonary arterial hypertension model.
Topics: Animals; Beverages; Caspase 3; Disease Models, Animal; Echocardiography; Familial Primary Pulmonary Hypertension; Hydrogen Peroxide; Hypertension, Pulmonary; Lipid Peroxidation; Male; Monocrotaline; Oxidation-Reduction; Rats; Rats, Wistar; Signal Transduction; Thioredoxins; Ventricular Remodeling; Vitis | 2012 |
Fluoxetine protects against monocrotaline-induced pulmonary arterial remodeling by inhibition of hypoxia-inducible factor-1α and vascular endothelial growth factor.
Topics: Animals; Antihypertensive Agents; Cell Proliferation; Disease Models, Animal; Fluoxetine; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vascular Endothelial Growth Factor A | 2012 |
PAR-2 inhibition reverses experimental pulmonary hypertension.
Topics: Adolescent; Adult; Animals; Antibodies, Neutralizing; Becaplermin; Benzamides; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imatinib Mesylate; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oligopeptides; Piperazines; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptor, Platelet-Derived Growth Factor beta; RNA Interference; Signal Transduction; Time Factors; Transfection; Tryptases; Young Adult | 2012 |
Relation of bosentan, iloprost, and sildenafil with growth factor levels in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Female; Hypertension, Pulmonary; Iloprost; Monocrotaline; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfonamides; Sulfones; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vasodilator Agents | 2012 |
Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension.
Topics: Animals; Antihypertensive Agents; Apoptosis; Blotting, Western; Caspase 3; Cells, Cultured; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Familial Primary Pulmonary Hypertension; Glyburide; Human Umbilical Vein Endothelial Cells; Humans; Hypertension, Pulmonary; Injections, Intraperitoneal; Male; MAP Kinase Signaling System; Monocrotaline; NG-Nitroarginine Methyl Ester; Nicorandil; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction; Ventricular Pressure | 2012 |
Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.
Topics: Aminopeptidases; Animals; Cell Proliferation; Cells, Cultured; Cyclohexanes; Disease Models, Animal; Fatty Acids, Unsaturated; Gene Expression Regulation; Glycoproteins; Heart Ventricles; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Cardiac; Myocytes, Smooth Muscle; Myofibroblasts; Platelet-Derived Growth Factor; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2012 |
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Case-Control Studies; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Cobalt; Cyclin B1; Disease Models, Animal; Dynamins; Enzyme Activation; Familial Primary Pulmonary Hypertension; Genetic Therapy; Glycolysis; GTP Phosphohydrolases; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microtubule-Associated Proteins; Mitochondria, Muscle; Mitochondrial Proteins; Mitosis; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pulmonary Artery; Quinazolinones; Rats; Rats, Sprague-Dawley; RNA Interference; Serine; Time Factors; Transfection | 2012 |
Role of Src tyrosine kinases in experimental pulmonary hypertension.
Topics: Animals; Apoptosis; Becaplermin; Benzamides; Cell Proliferation; Cells, Cultured; Chemotaxis; Dasatinib; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Imatinib Mesylate; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Pyrimidines; Rats; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Thiazoles; Time Factors | 2012 |
Platelet-mediated mesenchymal stem cells homing to the lung reduces monocrotaline-induced rat pulmonary hypertension.
Topics: Animals; Antibodies; Blood Platelets; Blood Pressure; Bone Marrow Cells; Familial Primary Pulmonary Hypertension; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; P-Selectin; Platelet Glycoprotein GPIIb-IIIa Complex; Rats; Rats, Sprague-Dawley; Tirofiban; Tyrosine | 2012 |
Beneficial effects of γ-aminobutyric acid on right ventricular pressure and pulmonary vascular remodeling in experimental pulmonary hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelin-1; gamma-Aminobutyric Acid; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Norepinephrine; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Ventricular Pressure | 2012 |
Erythropoietin, but not asialoerythropoietin or carbamyl-erythropoietin, attenuates monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Asialoglycoproteins; Disease Models, Animal; Erythropoietin; Hypertension, Pulmonary; Male; Monocrotaline; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Erythropoietin; RNA, Messenger; Treatment Outcome | 2012 |
Oxygen radicals and substance P in perinatal hypoxia-exaggerated, monocrotaline-induced pulmonary hypertension.
Topics: Animals; Antioxidants; Atmosphere Exposure Chambers; Blood Pressure; Body Weight; Capsaicin; Female; Heart Rate; Humans; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reactive Oxygen Species; Sensory System Agents; Substance P | 2012 |
Smooth muscle myosin inhibition: a novel therapeutic approach for pulmonary hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Epoprostenol; Female; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Monocrotaline; Nitroprusside; Piperazines; Pulmonary Artery; Purines; Rats; Sildenafil Citrate; Smooth Muscle Myosins; Sulfones; Swine; Vascular Resistance; Vasoconstriction; Vasodilator Agents | 2012 |
The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Pressure; Cardiac Output; Cardiovascular System; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Protein Kinase Inhibitors; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents | 2012 |
Attenuation of monocrotaline-induced pulmonary arterial hypertension in rats by rosuvastatin.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Familial Primary Pulmonary Hypertension; Fluorobenzenes; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide Synthase Type III; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Time Factors | 2012 |
Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension.
Topics: ADAM Proteins; ADAM17 Protein; Angiotensin II; Animals; Cells, Cultured; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Extracellular Matrix; Female; Fibroblasts; Hypertension, Pulmonary; Male; Membrane Proteins; Monocrotaline; Nitriles; Osteopontin; Phenols; Propionates; Pyrazoles; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Ventricular Remodeling | 2012 |
Acute effects of vardenafil on pulmonary artery responsiveness in pulmonary hypertension.
Topics: Animals; Hypertension, Pulmonary; Imidazoles; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Rats; Sulfones; Triazines; Vardenafil Dihydrochloride | 2012 |
Changes of gene expression after bone marrow cell transfusion in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cytokines; Enzymes; Gene Expression Regulation; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Survival Rate; Ventricular Function | 2012 |
[Pathological changes of monocrotaline-induced pulmonary hypertension in miniature pigs].
Topics: Animals; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocardium; Swine; Swine, Miniature | 2012 |
Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model.
Topics: Animals; Benzenesulfonamides; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Sulfonamides; Ventricular Pressure | 2012 |
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
Topics: Aniline Compounds; Animals; Calcimimetic Agents; Calcium Signaling; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthalenes; Phenethylamines; Propylamines; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; RNA Interference; Spermine; Time Factors; Transfection; Vasoconstriction | 2012 |
Role of secretory phospholipase A(2) in rhythmic contraction of pulmonary arteries of rats with monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Carbamates; Cyclooxygenase 2 Inhibitors; Hypertension, Pulmonary; Indolizines; Male; Monocrotaline; Nitrobenzenes; Phospholipases A2, Secretory; Pulmonary Artery; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Vasoconstriction | 2012 |
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.
Topics: Animals; Benzamides; Benzimidazoles; Case-Control Studies; Crk-Associated Substrate Protein; Disease Models, Animal; Endothelial Cells; Epidermal Growth Factor; Familial Primary Pulmonary Hypertension; Fibroblast Growth Factor 2; Gefitinib; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Mice; Monocrotaline; Myocytes, Smooth Muscle; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pulmonary Artery; Pyrimidines; Quinazolines; Quinolones; Rats; Signal Transduction | 2012 |
Longitudinal in vivo SPECT/CT imaging reveals morphological changes and cardiopulmonary apoptosis in a rodent model of pulmonary arterial hypertension.
Topics: Animals; Annexins; Apoptosis; Blood Pressure; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Heart Ventricles; Humans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocardium; Perfusion; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Systole; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Ventricular Remodeling | 2012 |
Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.
Topics: Actins; Animals; Arterioles; Blood Vessels; Cell Proliferation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Immunochemistry; Immunohistochemistry; KATP Channels; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pinacidil; Poisons; Polymerase Chain Reaction; Pulmonary Circulation; Rats; Simvastatin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Vasodilator Agents | 2012 |
Bortezomib alleviates experimental pulmonary arterial hypertension.
Topics: Animals; Boronic Acids; Bortezomib; Caspase 3; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Heart Ventricles; Humans; Hypertension, Pulmonary; Liver; Liver Function Tests; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Nitric Oxide Synthase Type III; Proteasome Inhibitors; Pulmonary Artery; Pyrazines; Rats; Rats, Sprague-Dawley | 2012 |
Monocrotaline-induced pulmonary arterial hypertension is attenuated by TNF-α antagonists via the suppression of TNF-α expression and NF-κB pathway in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Disease Models, Animal; Etanercept; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Hypertension, Pulmonary; Immunoglobulin G; Inflammation; Lung; Male; Monocrotaline; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2013 |
Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Case-Control Studies; Cells, Cultured; Disease Progression; Endothelium, Vascular; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Losartan; Male; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Proportional Hazards Models; Rats; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Up-Regulation | 2012 |
[Pathophysiological characteristics of rat pulmonary hypertension and cor pulmonale induced by monocrotaline].
Topics: Animals; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide; Pulmonary Heart Disease; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2012 |
Atorvastatin prevents dehydromonocrotaline-induced pulmonary hypertension in beagles.
Topics: Alkylating Agents; Animals; Atorvastatin; Cell Proliferation; Cytokines; Dogs; Endothelium, Vascular; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Pyrroles | 2012 |
Caveolin-1 expression during the progression of pulmonary hypertension.
Topics: Animals; Caveolin 1; Disease Models, Animal; Endothelial Cells; Gene Expression Profiling; Hypertension, Pulmonary; Lung; Male; Matrix Metalloproteinase 2; Monocrotaline; Myocardium; Rats; Rats, Sprague-Dawley | 2012 |
Oestradiol ameliorates monocrotaline pulmonary hypertension via NO, prostacyclin and endothelin-1 pathways.
Topics: Animals; Aromatase; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Endothelin-1; Epoprostenol; Estradiol; Female; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Nitric Oxide; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction | 2013 |
Iptakalim ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Endothelin-1; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; KATP Channels; Lung; Male; Monocrotaline; Natriuretic Peptide, Brain; Nitric Oxide; Propylamines; Rats; Rats, Wistar | 2013 |
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction.
Topics: Animals; Calcium; Diaphragm; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Contraction; Muscle Fibers, Skeletal; Muscle Weakness; Myosin Heavy Chains; Rats; Rats, Wistar; Sarcomeres | 2012 |
Assessment of the endothelial functions in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Aorta, Thoracic; Arginine; Disease Models, Animal; Endothelium, Vascular; Hydrogen Sulfide; Hypertension, Pulmonary; Iloprost; Male; Monocrotaline; Nitric Oxide; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2013 |
Additive effect of tadalafil and simvastatin on monocrotaline-induced pulmonary hypertension rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Arterioles; Carbolines; Disease Models, Animal; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Simvastatin; Tadalafil; Time Factors; Vasodilator Agents | 2012 |
Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.
Topics: Animals; Anoctamin-1; Calcium Channel Blockers; Chloride Channel Agonists; Chloride Channels; Cyclooxygenase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indomethacin; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nifedipine; Niflumic Acid; Patch-Clamp Techniques; Pulmonary Artery; Pyrimidines; Rats; Rats, Wistar; Serotonin; Thiazoles | 2012 |
BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cell Proliferation; Disease Models, Animal; DNA; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Indoles; Ligands; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Monocrotaline; Myocytes, Smooth Muscle; Protein Binding; Pyrroles; Rats; Receptor, trkB; Signal Transduction | 2012 |
Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension.
Topics: Animals; Citrate (si)-Synthase; Gene Expression; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Male; Mitochondria, Muscle; Monocrotaline; Muscle, Skeletal; Nuclear Respiratory Factor 1; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Wistar; RNA-Binding Proteins; Sirtuin 1; Transcription Factors; Ventricular Dysfunction, Right | 2013 |
Urotensin inhibition with palosuran could be a promising alternative in pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Arterioles; Endothelin-1; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Quinolines; Rats; Rats, Wistar; Transforming Growth Factor beta1; Urea; Urotensins | 2013 |
Peroxisome proliferator-activated receptor-γ ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor.
Topics: Animals; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Indoles; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Receptor, Serotonin, 5-HT2B; Rosiglitazone; Serotonin 5-HT2 Receptor Agonists; Thiazolidinediones; Thiophenes; Transcription Factor AP-1; Up-Regulation | 2012 |
Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Binding Sites; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell Proliferation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Disease Models, Animal; Dose-Response Relationship, Drug; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Inhibitor of Differentiation Protein 1; Male; Monocrotaline; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Phosphodiesterase 5 Inhibitors; Phosphorylation; Piperazines; Promoter Regions, Genetic; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Sildenafil Citrate; Smad1 Protein; Smad5 Protein; Sulfones; Transfection; Vasodilator Agents | 2013 |
[Protective effects of rosiglitazone intervention on monocrotaline-induced pulmonary arterial hypertension in rats and related inflammatory mechanisms].
Topics: Animals; Hypertension, Pulmonary; Inflammation; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones | 2012 |
Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA-Rho kinase and Akt signalling pathways in rats.
Topics: Airway Remodeling; Animals; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Fluoxetine; Hypertension, Pulmonary; Isoenzymes; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Selective Serotonin Reuptake Inhibitors | 2012 |
Improvement of exercise capacity in monocrotaline-induced pulmonary hypertension by the phosphodiesterase-5 inhibitor Vardenafil.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Imidazoles; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Physical Conditioning, Animal; Piperazines; Rats; Rats, Wistar; Sulfones; Triazines; Vardenafil Dihydrochloride | 2013 |
Effect of small hairpin RNA targeting endothelin-converting enzyme-1 in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Aspartic Acid Endopeptidases; Body Weight; Endothelin-Converting Enzymes; Heart Ventricles; Hypertension, Pulmonary; Lentivirus; Lung; Male; Metalloendopeptidases; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; RNA, Small Interfering; Survival Rate; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2012 |
Microtubule proliferation in right ventricular myocytes of rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Cells, Cultured; Colchicine; Heart Ventricles; Hypertension, Pulmonary; Male; Microtubules; Monocrotaline; Myocytes, Cardiac; Organ Size; Protein Multimerization; Protein Processing, Post-Translational; Rats; Rats, Wistar; Sarcomeres; Tubulin; Tubulin Modulators | 2013 |
Mesenchymal stem cells attenuate vascular remodeling in monocrotaline-induced pulmonary hypertension rats.
Topics: Animals; Atrial Remodeling; Hypertension, Pulmonary; Male; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2012 |
Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Cytosol; Disease Progression; Humans; Hypertension, Pulmonary; Inositol Phosphates; Male; Monocrotaline; Myocytes, Smooth Muscle; Naphthalenes; Nifedipine; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; Recombinant Fusion Proteins; Signal Transduction; Transfection; Up-Regulation; Vasoconstriction | 2013 |
Sildenafil improves long-term effect of endothelial progenitor cell-based treatment for monocrotaline-induced rat pulmonary arterial hypertension.
Topics: Animals; Cell- and Tissue-Based Therapy; Combined Modality Therapy; Endothelial Cells; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Stem Cell Transplantation; Stem Cells; Sulfones; Time; Vasodilator Agents | 2013 |
A novel Ca2+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension.
Topics: Acetylcholine; Animals; Benzodioxoles; Calcium Channel Blockers; Calcium Chloride; Cardiomegaly; Familial Primary Pulmonary Hypertension; Hydrazones; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Phenylephrine; Pulmonary Artery; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents | 2013 |
Effects of diesel exhaust enriched concentrated PM2.5 in ozone preexposed or monocrotaline-treated rats.
Topics: Air Pollutants; Animals; Blood Cell Count; Bronchoalveolar Lavage Fluid; Hypertension, Pulmonary; Inhalation Exposure; Lung; Macrophages, Alveolar; Male; Monocrotaline; Nasal Cavity; Ozone; Particle Size; Pneumonia; Proteins; Rats; Rats, Inbred Strains; Rats, Wistar; Uteroglobin; Vehicle Emissions | 2002 |
Cardiac modulations of ANG II receptor expression in rats with hypoxic pulmonary hypertension.
Topics: Animals; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Ligands; Male; Monocrotaline; Myocardium; Organ Size; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger | 2002 |
Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium.
Topics: Animals; Calibration; Cardiomegaly; Disease Models, Animal; Histocytochemistry; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Male; Monocrotaline; Myocardium; Myocytes, Cardiac; Myoglobin; Oxygen Consumption; Rats; Rats, Wistar; Succinate Dehydrogenase; Time Factors; Transcription Factors | 2002 |
Heme oxygenase-1 reduces murine monocrotaline-induced pulmonary inflammatory responses and resultant right ventricular overload.
Topics: Animals; Body Weight; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypertension, Pulmonary; Inflammation; Lung; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Monocrotaline; Myocytes, Cardiac; Rats; Stress, Mechanical; Ventricular Function, Right | 2002 |
Dexfenfluramine protects against pulmonary hypertension in rats.
Topics: Animals; Appetite Depressants; Body Weight; Dexfenfluramine; Eating; Endothelium, Vascular; Female; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Myocardium; Nitric Oxide Synthase; Obesity; Organ Size; Pancreatic Elastase; Pulmonary Artery; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Vascular Diseases | 2002 |
Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats.
Topics: Animals; Chemokine CCL2; Electroporation; Gene Expression; Genetic Therapy; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Intramuscular; Macrophages; Male; Monocrotaline; Monocytes; Plasmids; Pulmonary Circulation; Pulmonary Wedge Pressure; Rats; Rats, Sprague-Dawley; Survival Rate; Transgenes | 2002 |
Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.
Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Disease Models, Animal; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Organ Size; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Treatment Outcome; Tunica Intima | 2002 |
Acute and chronic effects of T-1032, a novel selective phosphodiesterase type 5 inhibitor, on monocrotaline-induced pulmonary hypertension in rats.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Drug Administration Schedule; Hypertension, Pulmonary; Isoquinolines; Male; Monocrotaline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridines; Rats; Rats, Wistar | 2002 |
[The effect and mechanism of felodipine on monocrotaline induced pulmonary hypertension in rats].
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Endothelins; Felodipine; Hypertension, Pulmonary; Male; Monocrotaline; Myocardium; Rats; Rats, Wistar; Systole | 2002 |
Pulmonary effects of ultrafine and fine ammonium salts aerosols in healthy and monocrotaline-treated rats following short-term exposure.
Topics: Administration, Inhalation; Aerosols; Air Pollutants; Ammonium Sulfate; Animals; Bronchoalveolar Lavage Fluid; Ferrous Compounds; Hypertension, Pulmonary; Lung; Macrophages, Alveolar; Male; Monocrotaline; Nitrates; Particle Size; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 2002 |
Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure.
Topics: Animals; Binding, Competitive; Cell Membrane; Disease Models, Animal; Eye Proteins; Fluoxetine; G-Protein-Coupled Receptor Kinase 1; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Size; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Neurotransmitter; Rhodopsin; Symporters | 2002 |
Tachykinin dysfunction attenuates monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Body Weight; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Organ Size; Rats; Rats, Wistar; Receptors, Tachykinin; RNA Interference; RNA, Double-Stranded; Substance P; Tachykinins | 2003 |
Effect of a surgical aortocaval fistula on monocrotaline-induced pulmonary hypertension.
Topics: Animals; Aorta, Abdominal; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Blood Pressure; Cardiac Output; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Tunica Intima; Ultrasonography, Doppler; Vena Cava, Inferior | 2003 |
Protective role of angiopoietin-1 in experimental pulmonary hypertension.
Topics: Angiogenesis Inducing Agents; Angiopoietin-1; Angiopoietin-2; Animals; Apoptosis; Body Weight; Caspase 3; Caspases; Cell Transplantation; Cells, Cultured; Cytoprotection; Genetic Therapy; Hypertension, Pulmonary; Lung; Membrane Glycoproteins; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; RNA, Messenger; Transfection; Transgenes; Ventricular Pressure | 2003 |
Activation of the right ventricular endothelin (ET) system in the monocrotaline model of pulmonary hypertension: response to chronic ETA receptor blockade.
Topics: Animals; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Endothelins; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Phenylpropionates; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A | 2003 |
Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats.
Topics: Adenoviridae; Animals; Apoptosis; Gene Transfer Techniques; Genetic Vectors; Humans; Hypertension, Pulmonary; Lung; Matrix Metalloproteinase Inhibitors; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-1 | 2003 |
Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells.
Topics: Adrenomedullin; Animals; Cells, Cultured; Disease Models, Animal; DNA; Drug Carriers; Endothelium, Vascular; Fetal Blood; Gelatin; Gene Transfer Techniques; Genetic Therapy; Green Fluorescent Proteins; Humans; Hybrid Cells; Hypertension, Pulmonary; Luminescent Proteins; Male; Monocrotaline; Peptides; Phagocytosis; Pulmonary Circulation; Rats; Rats, Nude; Stem Cell Transplantation; Stem Cells; Survival Rate; Vascular Resistance | 2003 |
Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat.
Topics: Actin Cytoskeleton; Adrenergic beta-Agonists; Animals; Biomechanical Phenomena; Body Weight; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Isoproterenol; Male; Monocrotaline; Myocardial Contraction; Norepinephrine; Organ Size; Rats; Rats, Wistar; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Stress, Mechanical | 2003 |
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats.
Topics: Administration, Oral; Animals; Biopsy, Needle; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Hemodynamics; Hypertension, Pulmonary; Immunohistochemistry; Male; Monocrotaline; Phosphodiesterase Inhibitors; Piperazines; Probability; Pulmonary Heart Disease; Purines; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sildenafil Citrate; Sulfones; Survival Rate; Time Factors | 2004 |
DA-8159, a potent cGMP phosphodiesterase inhibitor, attenuates monocrotaline-induced pulmonary hypertension in rats.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Heart; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocardium; Organ Size; Phosphodiesterase Inhibitors; Pyrimidines; Rats; Rats, Sprague-Dawley; Sulfonamides | 2003 |
Augmented pulmonary vascular and venous constrictions to N(G)-nitro-L-arginine methyl ester in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstriction | 2003 |
Gender differences in pulmonary arterial reactivity to dilatory agonists in pulmonary hypertension.
Topics: Acetylcholine; Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Endothelins; Female; Hypertension, Pulmonary; Male; Monocrotaline; Norepinephrine; Peptides; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sex; Vasodilation; Vasodilator Agents | 2003 |
Rhythmical contractions in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Endothelins; Hypertension, Pulmonary; Male; Monocrotaline; Periodicity; Prostaglandins; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction | 2003 |
Repeated inhalation of adrenomedullin ameliorates pulmonary hypertension and survival in monocrotaline rats.
Topics: Administration, Inhalation; Adrenomedullin; Animals; Antihypertensive Agents; Hypertension, Pulmonary; Male; Monocrotaline; Peptides; Prognosis; Pulmonary Artery; Rats; Rats, Wistar; Survival Rate; Vascular Resistance | 2003 |
Progressive development of pulmonary hypertension leading to right ventricular hypertrophy assessed by echocardiography in rats.
Topics: Animals; Disease Models, Animal; Disease Progression; Echocardiography; Echocardiography, Doppler, Pulsed; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar | 2003 |
Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats.
Topics: Animals; Endothelium, Vascular; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; P-Selectin; Rats; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Succinates; Survival Rate | 2003 |
Alpha 1-adrenoceptor subtypes mediating noradrenaline-induced contraction of pulmonary artery from pulmonary hypertensive rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Male; Monocrotaline; Norepinephrine; Prazosin; Pulmonary Artery; Rats; Receptors, Adrenergic, alpha-1; Vasoconstriction | 2003 |
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intracellular Signaling Peptides and Proteins; Male; Monocrotaline; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Survival Rate; Time Factors | 2004 |
Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats.
Topics: Animals; Arachidonate 5-Lipoxygenase; Drug Synergism; Gene Transfer Techniques; Heart Septum; Heart Ventricles; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocardium; Organ Size; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Distribution | 2004 |
Right ventricle-sparing heart transplantation effective against iatrogenic pulmonary hypertension.
Topics: Alkylating Agents; Animals; Dogs; Heart Transplantation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Iatrogenic Disease; Monocrotaline | 2004 |
[Involvement of tetrahydrobiopterin in local change of endothelium-dependent vasorelaxation in pulmonary hypertension].
Topics: Animals; Biopterins; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide Synthase; Oxygen; Pulmonary Artery; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |
Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Therapy, Combination; Gelatinases; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Iloprost; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Muscle, Smooth, Vascular; Naphthyridines; Oxygen; Phosphodiesterase Inhibitors; Pulmonary Artery; Pulmonary Gas Exchange; Pulmonary Heart Disease; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Ventricular Remodeling | 2004 |
Cell therapy for pulmonary hypertension: what is the true potential of endothelial progenitor cells?
Topics: Adrenomedullin; Animals; Cell Movement; Cells, Cultured; Endothelium, Vascular; Genetic Therapy; Hybrid Cells; Hypertension, Pulmonary; Male; Monocrotaline; Peptides; Rats; Rats, Nude; Regeneration; Stem Cell Transplantation | 2004 |
Longitudinal transcriptional analysis of developing neointimal vascular occlusion and pulmonary hypertension in rats.
Topics: Animals; Arterial Occlusive Diseases; Blotting, Northern; Cluster Analysis; Diterpenes; Epoxy Compounds; Gene Expression Profiling; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Longitudinal Studies; Male; Monocrotaline; Phenanthrenes; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Transcription, Genetic; Tunica Intima | 2004 |
Comparison of strength properties of normotensive and hypertensive rat pulmonary arteries.
Topics: Animals; Compressive Strength; Elasticity; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Long-Evans; Receptor, Endothelin B; Reference Values; Shear Strength; Stress, Mechanical; Tensile Strength | 2004 |
Emission-particle-induced ventilatory abnormalities in a rat model of pulmonary hypertension.
Topics: Animals; Carbon; Coal Ash; Disease Models, Animal; Hypertension, Pulmonary; Inflammation; Inhalation Exposure; Lung; Male; Monocrotaline; Particle Size; Particulate Matter; Rats; Rats, Sprague-Dawley; Respiratory Function Tests | 2004 |
[Effect of elastase inhibitor on pulmonary hypertension induced by monocrotaline].
Topics: Animals; Hypertension, Pulmonary; Male; Monocrotaline; Pancreatic Elastase; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2004 |
Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Atrasentan; Blood Pressure; Body Mass Index; Body Weight; Cardiomegaly; Drug Administration Schedule; Drug Therapy, Combination; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Intubation, Gastrointestinal; Lung; Male; Monocrotaline; Organ Size; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors; Tunica Media; Ventricular Pressure | 2004 |
The orally active nonpeptide selective endothelin ETA receptor antagonist YM598 prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats.
Topics: Administration, Oral; Animals; Blood Pressure; Endothelin A Receptor Antagonists; Heart Rate; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Sulfonamides | 2004 |
JTV-506, a new K(ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Chromans; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Channels; Pulmonary Artery; Rats; Rats, Wistar; Vasodilation | 2004 |
Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Ghrelin; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Peptide Hormones; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Ventricular Function, Left; Ventricular Function, Right | 2004 |
C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Antihypertensive Agents; Apoptosis; Cell Proliferation; Chemotaxis, Leukocyte; Fibrinolysis; Hemodynamics; Hypertension, Pulmonary; Injections, Subcutaneous; Male; Models, Animal; Monocrotaline; Natriuretic Peptide, C-Type; Pulmonary Artery; Rats; Rats, Wistar; Respiratory Mucosa; Survival Analysis; Toxins, Biological; Treatment Outcome | 2004 |
Disruption of endothelial-cell caveolin-1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Caveolin 1; Caveolins; Disease Models, Animal; DNA-Binding Proteins; Endothelial Cells; Endothelium, Vascular; Heat-Shock Proteins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isomerases; Male; Membrane Microdomains; Mitosis; Monocrotaline; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Proliferating Cell Nuclear Antigen; Protein Disulfide-Isomerases; Protein Processing, Post-Translational; Pulmonary Artery; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Trans-Activators; von Willebrand Factor | 2004 |
Role of endothelin ETB receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Animals, Genetically Modified; Atrasentan; Endothelin B Receptor Antagonists; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Pyrrolidines; Rats; Rats, Mutant Strains; Receptor, Endothelin B; Ventricular Function, Right | 2004 |
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.
Topics: Animals; Apoptosis; Cell Division; Cells, Cultured; Dichloroacetic Acid; Drug Evaluation, Preclinical; Gene Expression Regulation; Heart Failure; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kv1.5 Potassium Channel; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organ Specificity; Oxidative Phosphorylation; Potassium Channels, Voltage-Gated; Pulmonary Artery; Rats; Shab Potassium Channels; Vascular Resistance | 2004 |
[Effect of chronic administration of aminoguanidine on the reactivity of pulmonary vessels in rats with monocrotaline-induced pulmonary hypertension].
Topics: Acetylcholine; Animals; Blood Pressure; Endothelium, Vascular; Guanidines; Guanylate Cyclase; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2004 |
Hepatocyte growth factor suppresses vascular medial hyperplasia and matrix accumulation in advanced pulmonary hypertension of rats.
Topics: Animals; Arterioles; Collagen; Endothelin-1; Extracellular Matrix; Fibrosis; Genetic Therapy; Hepatocyte Growth Factor; Humans; Hyperplasia; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Proto-Oncogene Proteins c-met; Rats; Rats, Wistar; Transfection; Transforming Growth Factor beta; Tunica Media | 2004 |
Gene transfer of hepatocyte growth factor with prostacyclin synthase in severe pulmonary hypertension of rats.
Topics: Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Genetic Therapy; Heart Ventricles; Hepatocyte Growth Factor; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intramolecular Oxidoreductases; Monocrotaline; Organ Size; Pulmonary Artery; Rats; Rats, Wistar; Transfection | 2004 |
Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
Chloride channels and alpha1-adrenoceptor-mediated pulmonary artery smooth muscle contraction: effect of pulmonary hypertension.
Topics: Animals; Bumetanide; Calcium Channel Blockers; Chloride Channels; Chloride-Bicarbonate Antiporters; Hypertension, Pulmonary; Isometric Contraction; Male; Monocrotaline; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Niflumic Acid; Norepinephrine; Poisons; Pulmonary Artery; Rats; Receptors, Adrenergic, alpha-1; Sodium Potassium Chloride Symporter Inhibitors | 2004 |
Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cyclic AMP; Cytochrome P-450 Enzyme System; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intramolecular Oxidoreductases; Lung; Monocrotaline; Muscle, Skeletal; Plasmids; Prognosis; Pulmonary Artery; Rats; Survival Rate; Time Factors | 2004 |
Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease.
Topics: Animals; Arterioles; Bone Marrow Transplantation; Cell Differentiation; Cells, Cultured; Combined Modality Therapy; Endothelial Cells; Genetic Therapy; Genetic Vectors; Graft Survival; Humans; Hypertension, Pulmonary; Lung; Microscopy, Fluorescence; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Inbred F344; Stem Cell Transplantation; Transduction, Genetic | 2005 |
Monocrotaline-induced pulmonary hypertension correlates with upregulation of connective tissue growth factor expression in the lung.
Topics: Animals; Blood Pressure; Bronchi; Connective Tissue Growth Factor; Endothelial Cells; Epithelial Cells; Hypertension, Pulmonary; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Lung; Male; Monocrotaline; Pulmonary Alveoli; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2005 |
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Isoenzymes; Lung; Male; Monocrotaline; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2005 |
[Decrease of nitric oxide (NO)-cGMP-dependent vasodilatation in the vessels of lesser circulation in endothelial dysfunction].
Topics: Animals; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Guanidines; Hypertension, Pulmonary; Lung; Monocrotaline; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Pulmonary Circulation; Rats; Rats, Wistar; Vasodilation | 2005 |
YM598, an orally active ET(A) receptor antagonist, ameliorates the progression of cardiopulmonary changes and both-side heart failure in rats with cor pulmonale and myocardial infarction.
Topics: Administration, Oral; Animals; Cardiovascular Agents; Coronary Vessels; Disease Models, Animal; Disease Progression; Endothelin A Receptor Antagonists; Heart Failure; Hemodynamics; Hypertension, Pulmonary; Ligation; Male; Monocrotaline; Myocardial Infarction; Pulmonary Heart Disease; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Sulfonamides | 2004 |
Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension.
Topics: Administration, Inhalation; Animals; Disease Models, Animal; Hypertension, Pulmonary; Iloprost; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Vasodilator Agents; Ventricular Pressure | 2005 |
Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Cell Proliferation; Fluoxetine; Hypertension, Pulmonary; Lung; Monocrotaline; Muscle, Smooth, Vascular; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Plasma Membrane Transport Proteins; Up-Regulation | 2005 |
Macro- and micropulmonary hemodynamic changes to nitric oxide blockade in monocrotaline-induced pulmonary hypertension in rats--an in vivo approach.
Topics: Animals; Enzyme Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstriction | 2005 |
[Effects of peroxisome proliferator-activated receptor gamma ligands on monocrotaline-induced pulmonary hypertension in rats].
Topics: Animals; Apoptosis; Cell Proliferation; Hypertension, Pulmonary; Ligands; Male; Monocrotaline; Peroxisome Proliferator-Activated Receptors; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2005 |
The role of increased pulmonary blood flow in pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Atria; Heart Bypass, Right; Heart Valves; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Ultrasonography | 2005 |
Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats.
Topics: 2-Methoxyestradiol; Animals; Blood Pressure; Body Weight; Cell Proliferation; Disease Progression; Estradiol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Time Factors; Tubulin Modulators | 2005 |
Effects of nicorandil on monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Blotting, Western; Endothelium, Vascular; Follow-Up Studies; Heart Rate; Hypertension, Pulmonary; Immunohistochemistry; Leukocyte Common Antigens; Male; Monocrotaline; Nicorandil; Nitric Oxide Synthase; P-Selectin; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2005 |
Selective right, but not left, coronary endothelial dysfunction precedes development of pulmonary hypertension and right heart hypertrophy in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2006 |
Increased pulmonary heme oxygenase-1 and delta-aminolevulinate synthase expression in monocrotaline-induced pulmonary hypertension.
Topics: 5-Aminolevulinate Synthetase; Animals; DNA; Gene Expression; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Lung; Male; Monocrotaline; NF-kappa B; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2005 |
A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension.
Topics: Animals; Blood Pressure; Epoprostenol; Heart Rate; Hypertension, Pulmonary; Injections, Subcutaneous; Male; Monocrotaline; Pyridines; Rats; Rats, Wistar; Thromboxane B2; Thromboxane-A Synthase | 2005 |
[The effect of compound macrostem onion capsule on metabolism of arachidonic acid in a rat model of monocrotaline-induced pulmonary artery hypertension].
Topics: Animals; Arachidonic Acid; Drugs, Chinese Herbal; Hypertension, Pulmonary; Male; Monocrotaline; Onions; Phytotherapy; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2005 |
CPU 86017, p-chlorobenzyltetrahydroberberine chloride, attenuates monocrotaline-induced pulmonary hypertension by suppressing endothelin pathway.
Topics: Animals; Berberine; Blood Pressure; Calcium Channel Blockers; Endothelin-1; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vasoconstriction | 2005 |
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration.
Topics: Administration, Inhalation; Animals; Cell Movement; Dose-Response Relationship, Drug; Extracellular Matrix; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Smooth Muscle; Naphthyridines; Rats | 2005 |
Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blotting, Northern; Cell Cycle; Cell Proliferation; Heme Oxygenase (Decyclizing); Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Sirolimus | 2006 |
Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blotting, Western; Down-Regulation; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Genistein; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Vascular Resistance | 2006 |
Upregulation of profilin, cofilin-2 and LIMK2 in cultured pulmonary artery smooth muscle cells and in pulmonary arteries of monocrotaline-treated rats.
Topics: Animals; Cells, Cultured; Cofilin 2; Disease Models, Animal; Dogs; Hyperplasia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Lim Kinases; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Profilins; Protein Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha; Up-Regulation | 2006 |
Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer.
Topics: Animals; Fluorescein Angiography; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Lung; Monocrotaline; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Inbred F344; Regeneration; Time Factors; Vascular Endothelial Growth Factors | 2006 |
Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension.
Topics: Acute Disease; Animals; Blood Pressure; Blood Vessels; Humans; Hydroxyindoleacetic Acid; Hypertension, Pulmonary; Hypoxia; Lung; Mice; Mice, Transgenic; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Serotonin Plasma Membrane Transport Proteins; Tissue Distribution; Transgenes; Vasoconstriction; Ventricular Function, Right | 2006 |
Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats.
Topics: Angiotensinogen; Animals; Antihypertensive Agents; Bosentan; Cytochrome P-450 CYP11B2; Endothelin-1; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Myocardial Contraction; Natriuretic Peptide, Brain; Neurotransmitter Agents; Peptides, Cyclic; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Ventricular Function; Ventricular Remodeling | 2006 |
Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Proliferation; Chymases; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Peptidyl-Dipeptidase A; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; RNA, Messenger; Serine Endopeptidases; Tetrazoles; Tunica Media | 2006 |
Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats.
Topics: Animals; Coronary Vessels; Disulfides; Dose-Response Relationship, Drug; Endothelium, Vascular; Garlic; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Plant Extracts; Rats; Rats, Sprague-Dawley; Sulfinic Acids; Time Factors; Vasodilation | 2006 |
Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat.
Topics: Animals; Blood Pressure; Cardiac Output; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Male; Monocrotaline; Organ Size; Rats; Rats, Wistar; Stroke Volume; Time Factors; Ventricular Dysfunction, Right; Ventricular Pressure | 2006 |
Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats.
Topics: Animals; Bosentan; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfonamides; Sulfones | 2006 |
Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension.
Topics: Adenoviridae; Animals; Cells, Cultured; Disease Models, Animal; DNA, Complementary; Femoral Vein; Genetic Therapy; Genetic Vectors; Humans; Hypertension, Pulmonary; Injections, Intravenous; Male; Mesenchymal Stem Cell Transplantation; Monocrotaline; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right | 2006 |
2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension.
Topics: 2-Methoxyestradiol; Analysis of Variance; Animals; Blood Pressure; Disease Progression; Estradiol; Female; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Ovariectomy; Pulmonary Artery; Rats; Time Factors; Ventricular Function, Left; Ventricular Function, Right | 2006 |
The HMG-CoA reductase inhibitor, pravastatin, prevents the development of monocrotaline-induced pulmonary hypertension in the rat through reduction of endothelial cell apoptosis and overexpression of eNOS.
Topics: Acetylcholine; Animals; Apoptosis; Blood Pressure; Blotting, Western; Body Weight; Caspase 3; Disease Progression; Endothelial Cells; Heart Function Tests; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; In Situ Nick-End Labeling; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Nitroprusside; Poisons; Pravastatin; Pulmonary Artery; Rats; Rats, Wistar; Survival; Vasodilator Agents | 2006 |
Upregulated neurohumoral factors are associated with left ventricular remodeling and poor prognosis in rats with monocrotaline-induced pulmonary arterial hypertension.
Topics: Angiotensin II; Animals; Hypertension, Pulmonary; Hypertrophy, Left Ventricular; Male; Monocrotaline; Natriuretic Peptide, Brain; Norepinephrine; Prognosis; Rats; Rats, Wistar; Up-Regulation; Ventricular Remodeling | 2006 |
Short-term administration of a cell-permeable caveolin-1 peptide prevents the development of monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
Topics: Amino Acid Sequence; Animals; Biotinylation; Caveolin 1; Cell Membrane Permeability; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Molecular Sequence Data; Monocrotaline; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2006 |
Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages; Male; Monocrotaline; Mycophenolic Acid; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley | 2006 |
Myocyte morphological characteristics differ between the phases of pulmonary hypertension-induced ventricular hypertrophy and failure.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Disease Progression; Heart Failure; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Cells; Myocardium; Prognosis; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Ventricular Pressure; Ventricular Remodeling | 2006 |
Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction.
Topics: Acetylcholine; Animals; Blood Pressure; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Paracrine Communication; Phenotype; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Time Factors; Trachea; Vascular Resistance; Vasodilation; Vasodilator Agents | 2007 |
Sertraline protects against monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Gene Expression Regulation; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Wistar; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Sertraline | 2006 |
Protective role of protein C inhibitor in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Bronchoalveolar Lavage Fluid; Humans; Hypertension, Pulmonary; Intercellular Signaling Peptides and Proteins; Lung; Mice; Mice, Transgenic; Monocrotaline; Protein C Inhibitor; Thrombin | 2006 |
Sleeping Beauty-mediated eNOS gene therapy attenuates monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; DNA Transposable Elements; Gene Expression Regulation, Enzymologic; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley | 2006 |
The protective effect of HMG-CoA reductase inhibitors against monocrotaline-induced pulmonary hypertension in the rat might not be a class effect: comparison of pravastatin and atorvastatin.
Topics: Acetylcholine; Animals; Apoptosis; Atorvastatin; Caspase 3; Endothelial Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Nitroprusside; Pravastatin; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Ventricular Pressure | 2006 |
Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension.
Topics: Animals; Antigens, Differentiation; Cell Adhesion Molecules; Dendritic Cells; Disease Models, Animal; Humans; Hypertension, Pulmonary; Immunoenzyme Techniques; Lectins, C-Type; Lung; Male; Microscopy, Fluorescence; Monocrotaline; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Receptors, Cell Surface | 2007 |
Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Bone Morphogenetic Protein Receptors, Type II; Cardiac Output; Genetic Therapy; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Resistance | 2007 |
Propofol increases pulmonary vascular resistance during alpha-adrenoreceptor activation in normal and monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Hypertension, Pulmonary; Male; Monocrotaline; Propofol; Pulmonary Circulation; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Vascular Resistance | 2007 |
Granulocyte colony-stimulating factor prevents progression of monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Echocardiography; Endothelium, Vascular; Granulocyte Colony-Stimulating Factor; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Inbred F344 | 2007 |
Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.
Topics: Acetylcholine; Animals; Biological Factors; Catalase; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microcirculation; Microscopy, Video; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2007 |
[Expression of GATA6 gene in lung tissue of rat with pulmonary hypertension].
Topics: Animals; Blood Pressure; GATA6 Transcription Factor; Gene Expression Regulation; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ventricular Dysfunction, Right | 2006 |
Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation.
Topics: Animals; Animals, Genetically Modified; Arterioles; Bone Marrow Cells; Bone Marrow Transplantation; Capillaries; Cell Differentiation; Disease Models, Animal; Femoral Artery; Green Fluorescent Proteins; Hypertension, Pulmonary; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Pulmonary Embolism; Rats; Rats, Sprague-Dawley; Thrombosis; Tunica Intima; Ventricular Dysfunction, Right | 2007 |
Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Disease Models, Animal; Female; Green Fluorescent Proteins; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocrotaline; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Artery; Stem Cell Transplantation; Stem Cells; Time Factors; Ventricular Function, Right; Ventricular Pressure | 2007 |
Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Rate; Hypertension, Pulmonary; Intracellular Signaling Peptides and Proteins; Male; Monocrotaline; Poisons; Protein Serine-Threonine Kinases; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilation | 2007 |
Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats.
Topics: Amidohydrolases; Animals; Arginase; Arginine; Cyclic GMP; Endothelial Cells; Enzyme Activation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isometric Contraction; Lung; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction | 2007 |
Dysfunction of Golgi tethers, SNAREs, and SNAPs in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Cell Line; Cytoplasmic Vesicles; Endothelial Cells; Fluorescent Antibody Technique; Glycoside Hydrolases; Golgi Apparatus; Humans; Hypertension, Pulmonary; Male; Membrane Fusion; Monocrotaline; Phenotype; Protein Transport; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Respiratory Mucosa; SNARE Proteins; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins | 2007 |
Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Apoptosis; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Disease Models, Animal; Disease Progression; Down-Regulation; Hypertension, Pulmonary; Immunoblotting; Immunohistochemistry; Male; Monocrotaline; Polymerase Chain Reaction; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA; Signal Transduction; Smad4 Protein; Smad5 Protein; Smad6 Protein; Smad8 Protein | 2007 |
[Pulmonary hypertension treatment: future prospects].
Topics: Administration, Intranasal; Administration, Oral; Animals; Bosentan; Drug Evaluation, Preclinical; Endothelin A Receptor Antagonists; Epoprostenol; Forecasting; Humans; Hypertension, Pulmonary; Iloprost; Infusions, Intravenous; Isoxazoles; Life Expectancy; Lung Transplantation; Monocrotaline; Piperazines; Platelet-Derived Growth Factor; Purines; Randomized Controlled Trials as Topic; Rats; Sheep; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Vasodilator Agents | 2007 |
The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension.
Topics: Animals; Apoptosis; Disease Models, Animal; Hypertension, Pulmonary; Lung; Models, Biological; Monocrotaline; Mutation; Pulmonary Artery; Rats; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2007 |
Activity of endothelium-derived hyperpolarizing factor is augmented in monocrotaline-induced pulmonary hypertension of rat lungs.
Topics: Animals; Anti-Infective Agents; Apamin; Biological Factors; Charybdotoxin; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfaphenazole; Thapsigargin; Vascular Cell Adhesion Molecule-1; Vasodilation | 2007 |
Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy.
Topics: Adrenergic Fibers; Animals; Dopamine; Endothelin-1; GAP-43 Protein; Gene Expression Regulation; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kinetics; Male; Monocrotaline; Myocytes, Cardiac; Nerve Growth Factor; Neural Cell Adhesion Molecule L1; Norepinephrine; Rats; Rats, Wistar; Sialic Acids; Tubulin; Tyrosine 3-Monooxygenase; Up-Regulation | 2007 |
Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography.
Topics: Action Potentials; Animals; Body Surface Potential Mapping; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardial Contraction; Rats; Rats, Wistar; Severity of Illness Index; Systole; Time Factors; Ultrasonography; Ventricular Function, Right; Ventricular Pressure | 2007 |
Amlodipine prevents monocrotaline-induced pulmonary arterial hypertension and prolongs survival in rats independent of blood pressure lowering.
Topics: Amlodipine; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Blotting, Western; Cell Proliferation; Cytokines; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; Matrix Metalloproteinase 2; Monocrotaline; Nitric Oxide Synthase Type III; P-Selectin; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2007 |
[Changes of pulmonary artery protein kinase C activity in rats with chronic inflammatory pulmonary hypertension].
Topics: Animals; Chronic Disease; Hypertension, Pulmonary; Inflammation; Male; Monocrotaline; Protein Kinase C; Pulmonary Artery; Rats; Rats, Wistar | 2007 |
Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension.
Topics: Angiography; Animals; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Thromboplastin; Vascular Endothelial Growth Factor Receptor-2; von Willebrand Factor | 2007 |
[Effect of simvastatin on rat pulmonary hypertension induced by high pulmonary blood flow and injected monocrotaline].
Topics: Animals; Cholesterol; Hemodynamics; Hypertension, Pulmonary; Immunohistochemistry; Injections; Male; Monocrotaline; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Simvastatin | 2007 |
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted.
Topics: Animals; Apoptosis; Calcium Channels; Cell Line; Cyclosporine; Gene Targeting; Humans; Hypertension, Pulmonary; Kv1.5 Potassium Channel; Lung; Male; Mitochondrial Size; Monocrotaline; NFATC Transcription Factors; Oligopeptides; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley | 2007 |
Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cell Line; Cytochrome P-450 Enzyme System; Dependovirus; Epoprostenol; Feasibility Studies; Gene Transfer Techniques; Genetic Vectors; Heart Rate; Humans; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Injections, Intramuscular; Intramolecular Oxidoreductases; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Survival Analysis | 2007 |
Rodent models of PAH: are we there yet?
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Pneumonectomy; Pulmonary Artery; Radiography; Rats; Thromboplastin; Vascular Endothelial Growth Factor Receptor-2 | 2007 |
Oral sildenafil prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Lung Diseases, Interstitial; Male; Monocrotaline; Piperazines; Pulmonary Artery; Pulmonary Emphysema; Purines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sildenafil Citrate; Sulfones; Time Factors; Vasodilator Agents | 2007 |
Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Adenoviridae; Animals; Cells, Cultured; Chickens; Genetic Vectors; Humans; Hypertension, Pulmonary; Interleukin-10; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar | 2007 |
Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study.
Topics: Animals; Atorvastatin; Blood Pressure; Disease Progression; Dose-Response Relationship, Drug; Drug Synergism; Echocardiography; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphorylation; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Simvastatin; Sirolimus | 2007 |
Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Epoprostenol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Protein Kinase Inhibitors; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2007 |
[Changes of thrombomodulin in rats with pulmonary hypertension induced by monocrotaline].
Topics: Animals; Hypertension, Pulmonary; Monocrotaline; Rats; Rats, Sprague-Dawley; Thrombomodulin | 2007 |
Effects of erythropoietin on advanced pulmonary vascular remodelling.
Topics: Animals; Erythropoietin; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Neovascularization, Pathologic; Pulmonary Circulation; Rats; Rats, Wistar; Stem Cells; Time Factors; Vascular Endothelial Growth Factor A; Ventricular Remodeling | 2008 |
Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension.
Topics: Animals; Cardiac Output; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Signal Transduction | 2007 |
A nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate ameliorates pulmonary hypertension in rats.
Topics: Animals; Antioxidants; Disease Progression; Hypertension, Pulmonary; Immunohistochemistry; Lung; Macrophages; Male; Monocrotaline; NF-kappa B; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Vascular Cell Adhesion Molecule-1 | 2007 |
[Effect of triptolide on the development of monocrotaline-induced pulmonary hypertension in pneumonectomized rat].
Topics: Animals; Antihypertensive Agents; Diterpenes; Epoxy Compounds; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Phenanthrenes; Pneumonectomy; Rats; Rats, Sprague-Dawley | 2007 |
Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats.
Topics: Adenoviridae; Animals; beta-Galactosidase; Blood Pressure; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Heart Rate; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2008 |
Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats.
Topics: Animals; Antihypertensive Agents; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Epoprostenol; Extracellular Signal-Regulated MAP Kinases; Hemodynamics; Hypertension, Pulmonary; Injections, Subcutaneous; Male; Microspheres; Monocrotaline; Pyridines; Rats; Rats, Wistar; Thromboxane-A Synthase | 2008 |
Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.
Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthyridines; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rats | 2008 |
Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Disease Models, Animal; Female; Green Fluorescent Proteins; Heart; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocardium; Rats; Stem Cells; Wound Healing | 2008 |
Rosuvastatin provides pleiotropic protection against pulmonary hypertension, right ventricular hypertrophy, and coronary endothelial dysfunction in rats.
Topics: Animals; Blood Pressure; Blotting, Western; Body Weight; Coronary Disease; Endothelium, Vascular; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Organ Size; Poisons; Pyrimidines; Rats; Rats, Sprague-Dawley; Rosuvastatin Calcium; Sulfonamides | 2008 |
Cytoplasmic provenance of STAT3 and PY-STAT3 in the endolysosomal compartments in pulmonary arterial endothelial and smooth muscle cells: implications in pulmonary arterial hypertension.
Topics: Animals; Cattle; Caveolin 1; Cell Compartmentation; Cells, Cultured; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Lysosomes; Male; Monocrotaline; Muscle, Smooth, Vascular; Protein Disulfide-Isomerases; Protein Transport; Rats; STAT3 Transcription Factor | 2008 |
Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Hepatocytes; Hypertension, Pulmonary; Male; Monocrotaline; Plant Extracts; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured | 2008 |
Evaluation of olmesartan medoxomil in the rat monocrotaline model of pulmonary hypertension.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imidazoles; Lung; Male; Monocrotaline; Olmesartan Medoxomil; Pulmonary Artery; Rats; Rats, Wistar; Tetrazoles; Time Factors | 2008 |
Smad signaling in the rat model of monocrotaline pulmonary hypertension.
Topics: Activin Receptors; Animals; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Injections, Intraperitoneal; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad1 Protein; Smad2 Protein; Smad4 Protein; Transforming Growth Factor beta | 2008 |
Pyrrolidine dithiocarbamate restores endothelial cell membrane integrity and attenuates monocrotaline-induced pulmonary artery hypertension.
Topics: Acridines; Animals; Caveolin 1; Cell Membrane; Endothelial Cells; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; I-kappa B Proteins; Luminescent Measurements; Male; Monocrotaline; NF-kappa B; NF-KappaB Inhibitor alpha; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, TIE-2; STAT3 Transcription Factor; Superoxides; Thiocarbamates | 2008 |
Autologous transplantation of bone marrow-derived endothelial progenitor cells attenuates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Bone Marrow Transplantation; Endothelial Cells; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Sprague-Dawley | 2008 |
Cilostazol therapy attenuates monocrotaline-induced pulmonary arterial hypertension in rat model.
Topics: Animals; Blood Pressure; Body Weight; Cilostazol; Connexin 43; Disease Models, Animal; Endothelium, Vascular; Gene Expression; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasodilator Agents | 2008 |
Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone.
Topics: Adjuvants, Immunologic; Animals; Blood Pressure; Dehydroepiandrosterone; Enzyme Activation; Gene Expression Regulation, Enzymologic; Hypertension, Pulmonary; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Time Factors | 2008 |
Chemical sympathectomy and serotonin inhibition reduce monocrotaline-induced right ventricular hypertrophy in rats.
Topics: Animals; Cardiomegaly; Fenclonine; Hydroxydopamines; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Oxidopamine; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin Antagonists; Sympathectomy, Chemical | 1983 |
Pulmonary hypertension and ECG changes from monocrotaline pyrrole in the rat.
Topics: Animals; Blood Cell Count; Body Weight; Cardiomegaly; Electrocardiography; Heart; Heart Ventricles; Hypertension, Pulmonary; Kinetics; Lung; Male; Monocrotaline; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1983 |
Angiotensin converting enzyme activity and evolution of pulmonary vascular disease in rats with monocrotaline pulmonary hypertension.
Topics: Animals; Arterioles; Blood Pressure; Cardiomegaly; Female; Hypertension, Pulmonary; Lung; Monocrotaline; Muscle, Smooth, Vascular; Peptidyl-Dipeptidase A; Pulmonary Artery; Pulmonary Heart Disease; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1982 |
Lung angiotensin converting enzyme activity in monocrotaline pulmonary hypertension.
Topics: Animals; Hypertension, Pulmonary; Lung; Monocrotaline; Peptidyl-Dipeptidase A; Pyrrolizidine Alkaloids; Rats | 1984 |
[Morphological study of monocrotaline-induced pulmonary hypertension in rats].
Topics: Animals; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Alveoli; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1983 |
Abnormal alveolar cells in monocrotaline induced pulmonary hypertension.
Topics: Animals; Dose-Response Relationship, Drug; Foam Cells; Hypertension, Pulmonary; Leukocyte Count; Macrophages; Microscopy, Electron; Monocrotaline; Plants, Toxic; Pulmonary Alveoli; Pyrrolizidine Alkaloids; Rats; Senecio | 1983 |
Aggregation of platelets from monocrotaline pyrrole-treated rats.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Collagen; Hypertension, Pulmonary; Male; Monocrotaline; Platelet Aggregation; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Effects of monocrotaline treatment on norepinephrine removal by isolated, perfused rat lungs.
Topics: Animals; Biological Transport; Hypertension, Pulmonary; In Vitro Techniques; Lung; Male; Monocrotaline; Norepinephrine; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin | 1984 |
Polyamines and the development of monocrotaline-induced pulmonary hypertension.
Topics: Adenosylmethionine Decarboxylase; Animals; Blood Pressure; Eflornithine; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Kinetics; Lung; Male; Monocrotaline; Ornithine; Ornithine Decarboxylase Inhibitors; Plants, Toxic; Polyamines; Putrescine; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio; Spermidine; Spermine | 1984 |
Prolonged activation of rat lung ornithine decarboxylase in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Enzyme Activation; Hypertension, Pulmonary; Kinetics; Lung; Male; Monocrotaline; Ornithine Decarboxylase; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Development of Crotalaria pulmonary hypertension: hemodynamic and structural study.
Topics: Animals; Blood Gas Analysis; Body Temperature; Cardiomegaly; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Circulation; Pyrroles; Pyrrolizidine Alkaloids; Rats | 1980 |
Monocrotaline pyrrole-induced pulmonary hypertension in fawn-hooded rats with platelet storage pool deficiency: 5-hydroxytryptamine uptake by isolated, perfused lungs.
Topics: Animals; Blood Cell Count; Blood Platelets; Heart; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Organ Size; Perfusion; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin | 1983 |
Effects of thrombocytopenia on monocrotaline pyrrole-induced pulmonary hypertension.
Topics: Animals; Blood Platelets; Body Weight; Hypertension, Pulmonary; Immune Sera; Lung; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Thrombocytosis | 1984 |
Experimental study on monocrotaline induced pulmonary hypertensive rats. (1) Effect of long-term injection of immunosuppressant.
Topics: Animals; Blood Pressure; Heart Ventricles; Hypertension, Pulmonary; Immunosuppressive Agents; Injections; Male; Monocrotaline; Prednisolone; Pyrrolizidine Alkaloids; Rats | 1981 |
[Pathophysiological study on monocrotaline-induced pulmonary hypertension in rats (author's transl].
Topics: Animals; Capillary Permeability; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Alveoli; Pyrrolizidine Alkaloids; Rats | 1981 |
[Pulmonary circulatory disturbance due to pulmonary peripheral lesions--etiology of experimental pulmonary hypertension and cor pulmonale].
Topics: Animals; Hypertension, Pulmonary; Monocrotaline; Pulmonary Heart Disease; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1981 |
Increased alveolar-capillary membrane permeability by monocrotaline.
Topics: Animals; Blood Pressure; Capillaries; Capillary Permeability; Endothelium; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Alveoli; Pulmonary Artery; Pulmonary Edema; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1981 |
[Experimental pulmonary hypertension (author's transl)].
Topics: Animals; Cattle; Dogs; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Pyrroles; Pyrrolizidine Alkaloids; Rabbits; Rats; Sheep; Species Specificity; Swine | 1981 |
Membrane properties of smooth muscle cells in pulmonary hypertensive rats.
Topics: Animals; Cell Membrane; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Male; Membrane Potentials; Monocrotaline; Muscle, Smooth, Vascular; Organ Size; Plants, Toxic; Potassium; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio | 1982 |
Primary pulmonary hypertension, a review.
Topics: Aminorex; Animals; Cardiovascular Agents; Dogs; Dyspnea; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Prognosis; Pyrrolizidine Alkaloids; Rats | 1982 |
Failure to show decrease in small pulmonary blood vessels in rats with experimental pulmonary hypertension.
Topics: Animals; Arterioles; Chronic Disease; Female; Hypertension, Pulmonary; Hypoxia; Lung; Monocrotaline; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Venules | 1982 |
[Effects of prostaglandin E1 (PGE1) on pulmonary hypertension and lung vascular remodeling in a rat monocrotaline model of human pulmonary hypertension].
Topics: Alprostadil; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1995 |
Effects of calcium channel antagonists and pertussis toxin on noradrenaline-induced contractions in pulmonary artery from pulmonary hypertensive rats.
Topics: Animals; Aorta; Cadmium; Calcium Channel Blockers; Felodipine; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pertussis Toxin; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Virulence Factors, Bordetella | 1995 |
Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension.
Topics: Adrenomedullin; Animals; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Immunoblotting; Lung; Male; Monocrotaline; Myocardium; Peptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reference Values; RNA; RNA, Messenger; Ventricular Function, Right | 1995 |
Endothelin induced collagen remodeling in experimental pulmonary hypertension.
Topics: Animals; Collagen; Endothelins; Gene Expression; Hypertension, Pulmonary; Hypertrophy, Left Ventricular; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1995 |
Altered expression of ETB-receptor mRNA in the lung of rats with pulmonary hypertension.
Topics: Animals; Blood Pressure; Blotting, Northern; Endothelins; Hypertension, Pulmonary; Immunoenzyme Techniques; Lung; Male; Monocrotaline; Rats; Rats, Wistar; Receptors, Endothelin; RNA, Messenger | 1993 |
Capsaicin pretreatment attenuates monocrotaline-induced ventilatory dysfunction and pulmonary hypertension.
Topics: Animals; Blood Pressure; Body Weight; Capsaicin; Cardiomegaly; Endopeptidases; Hypertension, Pulmonary; Monocrotaline; Nerve Fibers; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Respiratory Tract Diseases; Substance P | 1993 |
Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Guanidines; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Male; Monocrotaline; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Pinacidil; Pulmonary Artery; Rats; Rats, Wistar; Vasoconstrictor Agents | 1994 |
[Pulmonary lobe transplantation in pulmonary hypertensive dogs under cardiopulmonary bypass].
Topics: Animals; Cardiopulmonary Bypass; Dogs; Hypertension, Pulmonary; Lung Transplantation; Monocrotaline | 1995 |
Pulmonary hypertension in rats. 1. Role of bromodeoxyuridine-positive mononuclear cells and alveolar macrophages.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Cytokines; Hypertension, Pulmonary; Leukocytes, Mononuclear; Macrophages, Alveolar; Male; Monocrotaline; Rats; Rats, Sprague-Dawley | 1995 |
L-arginine-related responses to pressure and vasoactive agents in monocrotaline-treated rat pulmonary arteries.
Topics: Air Pressure; Animals; Arginine; Calcium; Enzyme Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 1995 |
Establishment of canine pulmonary hypertension with dehydromonocrotaline. Importance of larger animal model for lung transplantation.
Topics: Animals; Disease Models, Animal; Dogs; Hemodynamics; Hypertension, Pulmonary; Lung Transplantation; Monocrotaline; Pulmonary Artery; Rats | 1995 |
A dehydromonocrotaline-induced pulmonary hypertension model in the beagle.
Topics: Animals; Disease Models, Animal; Dogs; Hypertension, Pulmonary; Monocrotaline | 1995 |
Sandostatin inhibits development of medial proliferation of pulmonary arteries in a rat model of pulmonary hypertension.
Topics: Animals; Cell Division; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Octreotide; Pulmonary Artery; Rats; Rats, Wistar | 1995 |
[Interleukin-2 activity in monocrotaline-treated rat lungs].
Topics: Animals; Hypertension, Pulmonary; Interleukin-2; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley | 1995 |
Enalapril improves heart failure induced by monocrotaline without reducing pulmonary hypertension in rats: roles of preserved myocardial creatine kinase and lactate dehydrogenase isoenzymes.
Topics: Animals; Atrial Natriuretic Factor; Cardiomyopathy, Hypertrophic; Creatine Kinase; Enalapril; Heart; Hypertension, Pulmonary; Isoenzymes; L-Lactate Dehydrogenase; Male; Monocrotaline; Myocardium; Norepinephrine; Rats; Rats, Wistar | 1995 |
[Changes in smooth muscle cell proliferation in pulmonary arteries of rats given monocrotaline].
Topics: Animals; Cell Division; DNA Replication; Hypertension, Pulmonary; Injections, Subcutaneous; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 1995 |
[The relationship of intraacinar pulmonary arterial structural remodelling with pulmonary hypertension].
Topics: Animals; Female; Hypertension, Pulmonary; Image Processing, Computer-Assisted; Monocrotaline; Pulmonary Alveoli; Pulmonary Artery; Rats; Rats, Wistar | 1995 |
Role of endothelin-1 in beagles with dehydromonocrotaline-induced pulmonary hypertension.
Topics: Animals; Azepines; Dogs; Endothelins; Hemodynamics; Hypertension, Pulmonary; Indoles; Monocrotaline; Peptides, Cyclic; Viper Venoms | 1995 |
Orally administered beraprost sodium inhibits pulmonary hypertension induced by monocrotaline in rats.
Topics: Administration, Oral; Animals; Blood Pressure; Dose-Response Relationship, Drug; Epoprostenol; Hypertension, Pulmonary; Injections, Subcutaneous; Monocrotaline; Platelet Aggregation Inhibitors; Rats; Rats, Wistar | 1994 |
Endothelin receptor antagonists in a beagle model of pulmonary hypertension: contribution to possible potential therapy?
Topics: Alprostadil; Animals; Azepines; Dogs; Endothelin Receptor Antagonists; Hemodynamics; Hypertension, Pulmonary; Indoles; Monocrotaline; Nitroglycerin; Peptides, Cyclic; Pulmonary Circulation | 1995 |
The effect of bunazosin on monocrotaline-induced pulmonary hypertension in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Quinazolines; Rats; Rats, Sprague-Dawley | 1994 |
Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline.
Topics: Animals; Blood Pressure; Disease Models, Animal; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Interleukin; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins | 1994 |
Effects of inhaled nitric oxide in rats with chemically induced pulmonary hypertension.
Topics: Administration, Inhalation; Animals; Blood Pressure; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Pulmonary Artery; Rats; Rats, Inbred F344 | 1994 |
Ultrastructural differences between pulmonary arteriolar muscularization induced by hypoxia and monocrotaline.
Topics: Animals; Arterioles; Female; Hypertension, Pulmonary; Hypoxia; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 1994 |
Myocardiopathy and expression of atrial natriuretic peptide in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Atrial Natriuretic Factor; Cardiomyopathies; Hypertension, Pulmonary; Immunohistochemistry; Male; Monocrotaline; Rats; Time Factors | 1994 |
[Role of serotonin in the progression of pulmonary hypertension].
Topics: Animals; Blood Platelets; Disease Models, Animal; Hypertension, Pulmonary; In Vitro Techniques; Lung; Male; Monocrotaline; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Triazines; Vasoconstriction | 1994 |
Interleukin-1 receptor antagonist inhibits pulmonary hypertension induced by inflammation.
Topics: Animals; Blood Pressure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lung; Male; Monocrotaline; Organ Size; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; RNA, Messenger; Sialoglycoproteins | 1994 |
Pathology of pulmonary hypertension: a human and experimental study.
Topics: Adult; Animals; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Japan; Male; Microscopy, Electron; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 1994 |
The endogenous vascular elastase that governs development and progression of monocrotaline-induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Western; Cattle; Complement Factor D; DNA Primers; Gene Expression; Humans; Hypertension, Pulmonary; Microscopy, Immunoelectron; Molecular Sequence Data; Monocrotaline; Muscle, Smooth, Vascular; Pancreatic Elastase; Polymerase Chain Reaction; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Homology, Amino Acid; Serine Endopeptidases | 1994 |
[Lung 3H-thymidine incorporation in monocrotaline (MCT)-treated rats--role of platelet-activating factor (PAF)].
Topics: Animals; Azepines; DNA; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thymidine; Triazoles | 1994 |
[Relationship between the converting ability of liver microsomes and monocrotaline-induced pulmonary hypertension in male, female and castrated male rats].
Topics: Animals; Castration; Female; Hypertension, Pulmonary; Male; Microsomes, Liver; Monocrotaline; Rats; Rats, Sprague-Dawley; Sex Factors | 1994 |
Possible involvement of endothelin-1 in cardiac hypertrophy.
Topics: Animals; Aorta, Thoracic; Aortic Valve Insufficiency; Cardiomegaly; Endothelins; Hypertension, Pulmonary; Hypertrophy, Left Ventricular; Male; Models, Biological; Monocrotaline; Myocardium; Rats; Rats, Wistar; RNA, Messenger | 1994 |
Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Gene Expression; Growth Substances; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1993 |
Protection by oestradiol against the development of cardiovascular changes associated with monocrotaline pulmonary hypertension in rats.
Topics: Animals; Behavior, Animal; Body Weight; Drug Implants; Estradiol; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Organ Size; Pulmonary Artery; Pulmonary Circulation; Pulmonary Edema; Rats; Rats, Sprague-Dawley | 1993 |
Right-to-left interatrial shunt in rats with progressive pulmonary hypertension.
Topics: Animals; Arteriovenous Shunt, Surgical; Heart Atria; Heart Function Tests; Hypertension, Pulmonary; Male; Monocrotaline; Prospective Studies; Rats; Rats, Inbred Lew; Respiratory Function Tests; Retrospective Studies; Vena Cava, Superior | 1993 |
Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats.
Topics: Animals; Blood Platelets; Culture Techniques; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Piperidines; Platelet Count; Pulmonary Artery; Rats; Serotonin; Serotonin Antagonists; Triazines | 1993 |
Effects of atrial natriuretic peptide and nitroprusside on isolated pulmonary resistance and conduit arteries from rats with pulmonary hypertension.
Topics: Animals; Atrial Natriuretic Factor; Dinoprost; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Nitroprusside; Pulmonary Artery; Rats; Rats, Wistar; Vasodilation | 1993 |
Dietary restriction, polyamines and monocrotaline-induced pulmonary hypertension.
Topics: Animals; Body Weight; DNA; Energy Intake; Heart Ventricles; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Organ Size; Ornithine Decarboxylase; Polyamines; Rats; Rats, Sprague-Dawley | 1993 |
The effect of nifedipine on monocrotaline-induced pulmonary hypertension in rats.
Topics: Acute Disease; Animals; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Injections, Intraperitoneal; Monocrotaline; Nifedipine; Organ Size; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley | 1993 |
Cardiac atrial natriuretic peptide in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Disease Models, Animal; Heart Atria; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Temporal alterations in specific basement membrane components in lungs from monocrotaline-treated rats.
Topics: Analysis of Variance; Animals; Basement Membrane; Blotting, Northern; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; Membrane Proteins; Monocrotaline; Rats; Rats, Sprague-Dawley | 1993 |
Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Endothelin-1; Endothelins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Lung; Male; Monocrotaline; Peptides, Cyclic; Protein Precursors; Pulmonary Artery; Rats; Rats, Wistar; RNA, Messenger; Vasoconstriction | 1993 |
Strain differences in the response of Fischer 344 and Sprague-Dawley rats to monocrotaline induced pulmonary vascular disease.
Topics: Animals; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Species Specificity; Weight Gain | 1993 |
Regulation of kininogen gene expression and localization in the lung after monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Blotting, Northern; Blotting, Western; DNA Probes; Endothelium, Vascular; Gene Expression Regulation; Hypertension, Pulmonary; Kidney; Kininogens; Liver; Lung; Monocrotaline; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1993 |
Role of nitric oxide and endothelin-1 in monocrotaline-induced pulmonary hypertension in rats.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arginine; Calcimycin; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Indomethacin; Male; Monocrotaline; Nitric Oxide; Nitroglycerin; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vasodilation | 1995 |
Cellular fibronectin and von Willebrand factor concentrations in plasma of rats treated with monocrotaline pyrrole.
Topics: Animals; Endothelium, Vascular; Fibronectins; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Time Factors; von Willebrand Factor | 1996 |
Protective effect of beraprost sodium, a stable prostacyclin analogue, in development of monocrotaline-induced pulmonary hypertension.
Topics: Alprostadil; Animals; Endothelium, Vascular; Epoprostenol; Hypertension, Pulmonary; Interleukin-1; Interleukin-6; Male; Mice; Monocrotaline; Platelet Aggregation Inhibitors; Poisons; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vasodilator Agents | 1996 |
Basic fibroblast growth factor alterations during development of monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Base Sequence; Blotting, Northern; Blotting, Western; Fibroblast Growth Factor 2; Hypertension, Pulmonary; Immunohistochemistry; Kinetics; Lung; Male; Molecular Sequence Data; Monocrotaline; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Tissue Distribution | 1995 |
Semotiadil improves survival of rats with monocrotaline-induced pulmonary hypertension: comparison with diltiazem.
Topics: Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Heart; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Wistar; Thiazoles | 1996 |
[Effect of tetrandrine on pulmonary hypertension induced by monocrotaline in rats].
Topics: Alkaloids; Animals; Benzylisoquinolines; Blood Pressure; Calcium Channel Blockers; Female; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Wistar | 1995 |
Tenascin synthesis, deposition, and isoforms in monocrotaline-induced pulmonary hypertensive rat lungs.
Topics: Animals; Blotting, Northern; Hypertension, Pulmonary; Immunohistochemistry; Isomerism; Lung; Male; Monocrotaline; Poisons; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tenascin | 1996 |
Site-specific responses to monocrotaline-induced vascular injury: evidence for two distinct mechanisms of remodeling.
Topics: Animals; Blotting, Northern; Endothelium, Vascular; Extracellular Matrix Proteins; Gene Expression; Hemodynamics; Hypertension, Pulmonary; In Situ Hybridization; Lung; Male; Monocrotaline; Poisons; Procollagen; Pulmonary Artery; Rats; Rats, Inbred F344; RNA, Messenger; Specific Pathogen-Free Organisms; Transforming Growth Factor beta; Tropoelastin | 1996 |
Growth factor expression and effects of amrinone in monocrotaline-induced pulmonary hypertension in rats.
Topics: Amrinone; Animals; Body Weight; Bronchi; Cardiotonic Agents; Fibroblast Growth Factor 2; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; Monocrotaline; Myocardium; Organ Size; Phosphodiesterase Inhibitors; Platelet-Derived Growth Factor; Poisons; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1996 |
Hypoxemia and elevated tachykinins in rat monocrotaline pneumotoxicity.
Topics: Animals; Hypertension, Pulmonary; Hypoxia; Lung; Male; Monocrotaline; Neprilysin; Pulmonary Gas Exchange; Rats; Rats, Sprague-Dawley; Substance P; Time Factors | 1996 |
Nebulized nitric oxide/nucleophile adduct reduces chronic pulmonary hypertension.
Topics: Aerosols; Animals; Chronic Disease; Drug Combinations; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Perfusion; Polyamines; Rats; Rats, Sprague-Dawley; Vasoconstriction | 1996 |
Telemetry monitoring of pulmonary arterial pressure in freely moving rats.
Topics: Animals; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Bosentan; Cardiac Catheterization; Hypertension, Pulmonary; Male; Monocrotaline; Motor Activity; Organ Size; Pulmonary Artery; Rats; Rats, Wistar; Sulfonamides; Telemetry; Weight Gain | 1996 |
Effect of endothelium of pulmonary artery vasoreactivity in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Endothelium, Vascular; Hypertension, Pulmonary; Male; Monocrotaline; Poisons; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 1996 |
Microsurgery in a rat lung transplant model: analysis of benefit.
Topics: Animals; Cardiac Output; Cost-Benefit Analysis; Disease Models, Animal; Graft Rejection; Heart Rate; Hypertension, Pulmonary; Lung Transplantation; Male; Microsurgery; Monocrotaline; Pulmonary Circulation; Rats; Rats, Wistar; Vascular Resistance | 1996 |
A selective type V phosphodiesterase inhibitor, E4021, protects the development of right ventricular overload and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Organ Size; Phosphodiesterase Inhibitors; Piperidines; Pulmonary Artery; Quinazolines; Rats; Rats, Wistar | 1996 |
Right ventricular failure--insights provided by a new model of chronic pulmonary hypertension.
Topics: Administration, Inhalation; Animals; Blood Pressure; Cardiac Output; Dogs; Heart Rate; Hemodynamics; Hypertension, Pulmonary; Infusions, Intravenous; Milrinone; Monocrotaline; Nitric Oxide; Pulmonary Artery; Pyridones; Vascular Resistance; Vasodilator Agents; Ventricular Dysfunction, Right; Ventricular Function, Right | 1997 |
Continuous low-dose NO inhalation does not prevent monocrotaline-induced pulmonary hypertension in rats.
Topics: Administration, Inhalation; Animals; Blood Pressure; Body Water; Dose-Response Relationship, Drug; Gases; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitrates; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sodium Chloride; Time Factors | 1997 |
Pulmonary hemodynamics and blood flow characteristics in chronic pulmonary hypertension.
Topics: Animals; Blood Flow Velocity; Chronic Disease; Disease Models, Animal; Dogs; Fourier Analysis; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Circulation; Pulmonary Wedge Pressure; Signal Processing, Computer-Assisted; Ultrasonography; Vascular Resistance | 1997 |
Milrinone improves pulmonary hemodynamics and right ventricular function in chronic pulmonary hypertension.
Topics: Animals; Cardiotonic Agents; Chronic Disease; Dogs; Fourier Analysis; Hypertension, Pulmonary; Milrinone; Monocrotaline; Pulmonary Circulation; Pulmonary Wedge Pressure; Pyridones; Signal Processing, Computer-Assisted; Ultrasonography; Vascular Resistance; Vasodilator Agents; Ventricular Function, Right | 1997 |
[Role of leukotriene B4 in monocrotaline-induced pulmonary hypertension].
Topics: Animals; Hypertension, Pulmonary; Leukotriene B4; Monocrotaline; Rats; Rats, Sprague-Dawley | 1997 |
Selective upregulation of arterial endothelial nitric oxide synthase in pulmonary hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine Vasopressin; Blood Pressure; Chronic Disease; Endothelium, Vascular; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Ionomycin; Lung; Male; Monocrotaline; Nitric Oxide Synthase; Prostaglandin Endoperoxides, Synthetic; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vascular Resistance; Vasoconstrictor Agents | 1997 |
Role of inhibition of nitric oxide production in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Arterioles; Blood Pressure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Male; Molsidomine; Monocrotaline; Nitrates; Nitric Oxide; Poisons; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Weight Gain | 1997 |
Nitric oxide improves pulmonary vascular impedance, transpulmonary efficiency, and left ventricular filling in chronic pulmonary hypertension.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dogs; Fourier Analysis; Hemodynamics; Hypertension, Pulmonary; Lung; Monocrotaline; Nitric Acid; Pulmonary Artery; Regional Blood Flow; Ventricular Function, Left | 1997 |
Single lung transplantation for canine pulmonary hypertension.
Topics: Animals; Cardiopulmonary Bypass; Disease Models, Animal; Dogs; Hemodynamics; Hypertension, Pulmonary; Lung Transplantation; Monocrotaline; Organ Size; Pulmonary Circulation; Reproducibility of Results | 1997 |
An adult canine model of chronic pulmonary hypertension for cardiopulmonary transplantation.
Topics: Age Factors; Animals; Catheterization, Swan-Ganz; Chronic Disease; Disease Models, Animal; Dogs; Heart-Lung Transplantation; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Reproducibility of Results; Ventricular Function | 1997 |
Monocrotaline metabolism and distribution in Fisher 344 and Sprague-Dawley rats.
Topics: Animals; Bile; Biotransformation; Carboxylesterase; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Feces; Glutathione; Hypertension, Pulmonary; Liver; Male; Microsomes, Liver; Monocrotaline; Perfusion; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Species Specificity; Tissue Distribution | 1997 |
[Effect of tetrandrine on intraacinar pulmonary arterial structural remodelling and pulmonary hypertension].
Topics: Alkaloids; Animals; Benzylisoquinolines; Calcium Channel Blockers; Female; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar | 1996 |
Exaggerated pulmonary hypertension with monocrotaline in rats susceptible to chronic mountain sickness.
Topics: Altitude; Altitude Sickness; Animals; Blood Gas Analysis; Blood Pressure; Heart Ventricles; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Organ Size; Poisons; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Respiratory Mechanics | 1997 |
Hemodynamic and inotropic effects of nitric oxide in pulmonary hypertension.
Topics: Animals; Body Weight; Disease Models, Animal; Dogs; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Myocardial Contraction; Nitric Oxide; Pulmonary Circulation; Regional Blood Flow; Vascular Resistance | 1997 |
Prolonged administration of L-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats.
Topics: Animals; Arginine; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Injections, Intraperitoneal; Monocrotaline; Poisons; Pulmonary Artery; Pulmonary Circulation; Rats | 1997 |
Bioactivation of monocrotaline by P-450 3A in rat liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Heart; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Immunoglobulin G; Liver; Male; Microsomes, Liver; Monocrotaline; Orchiectomy; Organ Size; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Sex Factors; Ventricular Pressure | 1997 |
Lung angiotensin receptor binding characteristics during the development of monocrotaline-induced pulmonary hypertension.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Biphenyl Compounds; Hypertension, Pulmonary; Imidazoles; Losartan; Lung; Male; Monocrotaline; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1997 |
The orally active ET(A) receptor antagonist (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphe nyl-propionic acid (LU 135252) prevents the development of pulmonary hypertension and endothelial metabolic dysfunction in monocrotaline-treated ra
Topics: Administration, Oral; Animals; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Peptidyl-Dipeptidase A; Phenylpropionates; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Ventricular Function, Right | 1997 |
Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension.
Topics: Actins; Animals; Disease Models, Animal; Hemodynamics; Hyperplasia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Tunica Intima | 1997 |
Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Antihypertensive Agents; Bosentan; Cardiac Output; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Neovascularization, Pathologic; Organ Size; Poisons; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
[Observation of relationship between function and structure of experimental pulmonary artery hypertension in rats and inhibitory effect of garlicin and other herbal medicines].
Topics: Alkaloids; Allyl Compounds; Animals; Antihypertensive Agents; Benzylisoquinolines; Blood Pressure; Disulfides; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Pyrazines; Random Allocation; Rats; Rats, Wistar; Vasodilator Agents | 1996 |
Pulmonary vascular impedance and recipient chronic pulmonary hypertension following cardiac transplantation.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dogs; Electric Impedance; Fourier Analysis; Heart Transplantation; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Poisons; Prospective Studies; Pulmonary Artery | 1997 |
Prolonged inhaled NO attenuates hypoxic, but not monocrotaline-induced, pulmonary vascular remodeling in rats.
Topics: Administration, Inhalation; Animals; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 1998 |
Cardiac and vascular responses after monocrotaline-induced hypertrophy in rats.
Topics: Animals; Body Weight; Disease Models, Animal; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardial Contraction; Poisons; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Stimulation, Chemical; Vasoconstriction | 1998 |
Thromboxane inhibition and monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Bridged Bicyclo Compounds; Disease Models, Animal; Eicosanoids; Fatty Acids, Monounsaturated; Hypertension, Pulmonary; Male; Methacrylates; Monocrotaline; Prostaglandin Antagonists; Rats; Rats, Wistar; Reference Values; Thromboxane A2; Thromboxane-A Synthase | 1997 |
Pulmonary artery remodeling differs in hypoxia- and monocrotaline-induced pulmonary hypertension.
Topics: Adaptation, Physiological; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Blood Pressure; Captopril; Hypertension, Pulmonary; Hypertrophy, Left Ventricular; Hypoxia; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar | 1998 |
Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1.
Topics: Animals; Antibodies; Cell Movement; Chemokine CCL2; Hypertension, Pulmonary; Immunohistochemistry; Injections, Subcutaneous; Macrophages; Male; Monocrotaline; Rats; Rats, Sprague-Dawley | 1998 |
EndothelinA receptor blockade improves nitric oxide-mediated vasodilation in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Endothelin Receptor Antagonists; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phenylpropionates; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Vasodilation | 1998 |
Type V phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Immunohistochemistry; Male; Monocrotaline; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Pulmonary Artery; Quinazolines; Rats; Rats, Wistar; Receptors, Endothelin | 1998 |
MCAF/MCP-1 protein expression in a rat model for pulmonary hypertension induced by monocrotaline.
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Hypertension, Pulmonary; Macrophages, Alveolar; Male; Monocrotaline; Rats; Rats, Sprague-Dawley | 1998 |
Hemodynamic and inotropic effects of milrinone after heart transplantation in the setting of recipient pulmonary hypertension.
Topics: Animals; Dogs; Heart Transplantation; Hemodynamics; Hypertension, Pulmonary; Milrinone; Monocrotaline; Myocardial Contraction; Phosphodiesterase Inhibitors; Pulmonary Circulation; Pyridones; Ventricular Dysfunction, Right; Ventricular Function, Right | 1998 |
Angiotensin-converting enzyme inhibition delays pulmonary vascular neointimal formation.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Northern; Cell Division; Disease Models, Animal; Elastic Tissue; Feasibility Studies; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; In Situ Hybridization; Male; Monocrotaline; Organ Size; Pneumonectomy; Poisons; Procollagen; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Tropoelastin; Tunica Intima; Tunica Media | 1998 |
Endothelin converting enzyme inhibitor protects development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Aspartic Acid Endopeptidases; Blood Pressure; Endothelin-Converting Enzymes; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Male; Metalloendopeptidases; Monocrotaline; Organ Size; Poisons; Pulmonary Artery; Rats; Rats, Wistar; Tetracyclines | 1998 |
Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline.
Topics: Adrenomedullin; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Infusion Pumps, Implantable; Lung; Male; Monocrotaline; Organ Size; Peptides; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar | 1998 |
[Preventive effects of tetrandrine on pulmonary hypertension and right ventricular hypertrophy in rats induced by monocrotaline].
Topics: Alkaloids; Animals; Benzylisoquinolines; Blood Pressure; Calcium Channel Blockers; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Wistar | 1996 |
Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats.
Topics: Air Pollutants; Air Pollution, Indoor; Animals; Body Temperature; Cardiovascular System; Disease Models, Animal; Heart Rate; Hypertension, Pulmonary; Leukocyte Count; Lung; Monocrotaline; Particle Size; Rats; Reproducibility of Results | 1998 |
Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension.
Topics: Animals; Chronic Disease; Endothelial Growth Factors; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Lung; Lymphokines; Male; Monocrotaline; Myocardium; Organ Size; Rats; Rats, Wistar; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Alteration in lung particle translocation, macrophage function, and microfilament arrangement in monocrotaline-treated rats.
Topics: Actin Cytoskeleton; Animals; Hypertension, Pulmonary; Lung; Macrophages, Alveolar; Male; Microscopy, Confocal; Microspheres; Monocrotaline; Phagocytosis; Rats; Rats, Sprague-Dawley | 1998 |
Suppressive effect of prostaglandin E1 on pulmonary hypertension induced by monocrotaline in rats.
Topics: Alprostadil; Animals; Calcium; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Septum; Heart Ventricles; Hypertension, Pulmonary; Macrophages, Alveolar; Male; Monocrotaline; Pulmonary Wedge Pressure; Rats; Rats, Sprague-Dawley | 1999 |
Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension.
Topics: Animals; Enzyme Inhibitors; Guanidines; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Male; Monocrotaline; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Pulmonary Circulation; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution; Vasomotor System | 1999 |
Endothelin-1 is elevated in monocrotaline pulmonary hypertension.
Topics: Angiotensin II; Animals; Drug Combinations; Endothelin-1; Endothelins; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Lung; Male; Monocrotaline; Oligopeptides; omega-N-Methylarginine; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Vasoconstriction | 1999 |
Combined inhaled nitric oxide and inhaled prostacyclin during experimental chronic pulmonary hypertension.
Topics: Administration, Inhalation; Animals; Blood Pressure; Chronic Disease; Drug Synergism; Epoprostenol; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasodilation | 1999 |
Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Animals; Chronic Disease; Dogs; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Myocardium; Pulmonary Circulation; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Stroke Volume; Ventricular Function, Right | 1999 |
Tetrandrine inhibited chronic "inflammatory" pulmonary hypertension in rats.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylisoquinolines; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Wistar | 1997 |
Reversal of impaired calcium homeostasis in the rat diaphragm subjected to Monocrotaline-induced pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Carcinogens; Diaphragm; Homeostasis; Hypertension, Pulmonary; In Vitro Techniques; Indapamide; Male; Monocrotaline; Rats; Rats, Sprague-Dawley | 1999 |
Dietary retinol inhibits inflammatory responses of rats treated with monocrotaline.
Topics: Animals; Carcinogens; Diet; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Injections, Subcutaneous; Lung; Male; Monocrotaline; Pulmonary Artery; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; Vitamin A | 1999 |
Improvement of mortality by long-term E4010 treatment in monocrotaline-induced pulmonary hypertensive rats.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Atrial Natriuretic Factor; Body Weight; Calcium Signaling; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Hypertension, Pulmonary; Ligands; Male; Monocrotaline; Nitric Oxide; Nitriles; Organ Size; Phosphodiesterase Inhibitors; Piperidines; Rats; Rats, Wistar; Survival Rate | 1999 |
Inhaled nitric oxide and nifedipine have similar effects on lung cGMP levels in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Inhalation; Animals; Bronchodilator Agents; Cyclic AMP; Cyclic GMP; Down-Regulation; Enzyme Inhibitors; Epoprostenol; Hypertension, Pulmonary; Hypoxia; Lung; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Poisons; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1999 |
Impaired endothelium-dependent relaxation by adrenomedullin in monocrotaline-treated rat arteries.
Topics: Acetylcholine; Adrenomedullin; Animals; Aorta, Thoracic; Body Weight; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Organ Size; Peptides; Pulmonary Artery; Rats; Rats, Wistar; Time Factors; Vasodilation; Vasodilator Agents | 1999 |
Lung injury from intratracheal and inhalation exposures to residual oil fly ash in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: Administration, Inhalation; Air Pollutants; Animals; Bronchoalveolar Lavage Fluid; Carbon; Coal Ash; Cytokines; Disease Models, Animal; DNA, Complementary; Hypertension, Pulmonary; Intubation, Intratracheal; Lung; Lung Diseases; Male; Monocrotaline; Particulate Matter; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Survival Rate | 1999 |
Cell-based gene transfer to the pulmonary vasculature: Endothelial nitric oxide synthase overexpression inhibits monocrotaline-induced pulmonary hypertension.
Topics: Animals; beta-Galactosidase; Blood Pressure; Cell Transplantation; Cells, Cultured; Flow Cytometry; Fluorescent Dyes; Gene Expression; Gene Transfer Techniques; Hypertension, Pulmonary; Lung; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Inbred F344; Rhodamines; Time Factors; Transfection; Ventricular Function, Right | 1999 |
Mechanisms underlying the impairment of endothelium-dependent relaxation in the pulmonary artery of monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Body Weight; Calcium; Carbachol; Cyclic GMP; Endothelium, Vascular; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Muscarinic Agonists; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
Apoptosis and atrophy in rat slow skeletal muscles in chronic heart failure.
Topics: Animals; Apoptosis; Atrophy; Blotting, Western; Body Weight; Caspase 3; Caspases; Cell Nucleus; Chronic Disease; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Male; Monocrotaline; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Myosin Heavy Chains; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Ubiquitins | 1999 |
Effects of physiological or pathological pressure load in vivo on myocardial expression of ET-1 and receptors.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; DNA, Complementary; Endothelin-1; Endothelins; Gene Expression; Hypertension, Pulmonary; Male; Monocrotaline; Myocardium; Natriuretic Peptide, Brain; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; RNA, Messenger; Ventricular Function, Left; Ventricular Function, Right | 1999 |
(+)-[3H]isradipine and [3H]glyburide bindings to heart and lung membranes from rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Calcium Channels, L-Type; Glyburide; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoglycemic Agents; In Vitro Techniques; Isradipine; KATP Channels; Kinetics; Lung; Male; Membranes; Monocrotaline; Myocardium; Poisons; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley | 1999 |
Cardiac endothelin and big endothelin in right-heart hypertrophy due to monocrotaline-induced pulmonary hypertension in rat.
Topics: Analysis of Variance; Angiotensin II; Animals; Atrial Natriuretic Factor; Endothelin-1; Endothelins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Myocardium; Perfusion; Poisons; Protein Precursors; Rats; Rats, Sprague-Dawley | 1999 |
Athymic nude rats develop severe pulmonary hypertension following monocrotaline administration.
Topics: Animals; Hypertension, Pulmonary; Injections, Subcutaneous; Lung; Male; Mast Cells; Monocrotaline; Pulmonary Artery; Rats; Rats, Inbred F344; Rats, Nude; Thymus Gland | 2000 |
Development of monocrotaline-induced pulmonary hypertension is attenuated by a serotonin receptor antagonist.
Topics: Animals; Cell Division; Endothelium, Vascular; Hypertension, Pulmonary; Male; Monocrotaline; Proliferating Cell Nuclear Antigen; Pulmonary Alveoli; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Succinates | 2000 |
Remodeling of gap junctional coupling in hypertrophied right ventricles of rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Cell Communication; Gap Junctions; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Male; Monocrotaline; Rats; Rats, Wistar | 2000 |
Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Isoxazoles; Male; Monocrotaline; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Thiophenes; Vasoconstriction; Weight Gain | 2000 |
Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pancreatic Elastase; Protease Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2000 |
Effects of concentrated ambient particles in rats and hamsters: an exploratory study.
Topics: Age Factors; Air Pollutants; Air Pollution; Animals; Blood Cell Count; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart Rate; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Maximum Allowable Concentration; Mesocricetus; Monocrotaline; Mortality; Particle Size; Rats; Rats, Inbred F344; Time Factors | 2000 |
Alterations of endothelium and smooth muscle function in monocrotaline-induced pulmonary hypertensive arteries.
Topics: Animals; Calcium; Culture Media; Endothelium, Vascular; Hypertension, Pulmonary; Intracellular Membranes; Male; Membrane Potentials; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide; Osmolar Concentration; Pulmonary Artery; Rats; Rats, Wistar; Vasodilator Agents; Vasomotor System | 2000 |
Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Humans; Hypertension, Pulmonary; Immunohistochemistry; Intramolecular Oxidoreductases; Liposomes; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Respirovirus; Survival Analysis | 2000 |
Chronic treatment with probucol effectively inhibits progression of pulmonary hypertension in rats.
Topics: Animals; Anticholesteremic Agents; Blood Pressure; Diet; Disease Progression; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Probucol; Rats; Rats, Wistar; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure | 2000 |
Endothelin-A-receptor antagonist and oral prostacyclin analog are comparably effective in ameliorating pulmonary hypertension and right ventricular hypertrophy in rats.
Topics: Administration, Oral; Animals; Endothelin Receptor Antagonists; Epoprostenol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Sulfonamides | 2000 |
Endothelin-1 and right-sided heart failure in rats: effects of an endothelin receptor antagonist on the failing right ventricle.
Topics: Animals; Cardiac Output, Low; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Male; Monocrotaline; Oxazoles; Rats; Rats, Wistar; Receptor, Endothelin A; Sulfonamides | 2000 |
Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Diterpenes; Drug Evaluation, Preclinical; Epoxy Compounds; Hemodynamics; Hypertension, Pulmonary; Immunosuppressive Agents; Male; Monocrotaline; Neovascularization, Pathologic; Phenanthrenes; Pneumonectomy; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Time Factors; Tunica Intima | 2000 |
40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats.
Topics: Animals; Cell Division; Disease Models, Animal; Everolimus; Fibromuscular Dysplasia; Hemodynamics; Hypertension, Pulmonary; Immunosuppressive Agents; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Sirolimus; Tunica Intima | 2001 |
Mechanical stretch augments PDGF receptor beta expression and protein tyrosine phosphorylation in pulmonary artery tissue and smooth muscle cells.
Topics: Animals; Blood Pressure; Blotting, Southern; Blotting, Western; Cells, Cultured; DNA, Complementary; Endothelium; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hypertension, Pulmonary; Luminescent Measurements; Male; Monocrotaline; Muscle, Smooth; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Pulmonary Artery; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; RNA, Messenger; Stress, Mechanical; Time Factors | 2000 |
Effectiveness of a nonselective ET(A/B) and a selective ET(A) antagonist in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Phenylpropionates; Pulmonary Circulation; Pyrimidines; Rats; Rats, Sprague-Dawley; Vascular Resistance | 2001 |
Reactive oxygen species and substance P in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Body Weight; Carbon; Free Radical Scavengers; Hematocrit; Hypertension, Pulmonary; Immunoenzyme Techniques; Luminescent Measurements; Male; Monocrotaline; Muscle, Smooth, Vascular; Poisons; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Reactive Oxygen Species; Substance P; Thiourea | 2001 |
The effects of single lung transplantation in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Hypertension, Pulmonary; Lung Transplantation; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Inbred F344; Time Factors | 1994 |
Capsaicin pre- and post-treatment on rat monocrotaline pneumotoxicity.
Topics: Animals; Capsaicin; Functional Residual Capacity; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Neprilysin; Neurokinin A; Organ Size; Rats; Rats, Sprague-Dawley; Substance P; Total Lung Capacity | 2000 |
[Effects of an extract of salviae miltiorrhizae (764-3) on structural remodeling of intra-acinar pulmonary artery in pulmonary hypertension due to chronic hypoxia and monocrotaline in rats].
Topics: Animals; Collagen; Drugs, Chinese Herbal; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Pulmonary Alveoli; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar | 1998 |
Beneficial effects on skeletal muscle of the angiotensin II type 1 receptor blocker irbesartan in experimental heart failure.
Topics: Angiotensin II; Animals; Apoptosis; Biphenyl Compounds; Calcium Channel Blockers; Drug Evaluation, Preclinical; Gene Expression Regulation; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Infusion Pumps, Implantable; Irbesartan; Male; Monocrotaline; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Nifedipine; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Tetrazoles; Tumor Necrosis Factor-alpha | 2001 |
Contribution of chloride channel activation to the elevated muscular tone of the pulmonary artery in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Base Sequence; Calcium; Chloride Channels; Cytosol; DNA Primers; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Tonus; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Verapamil | 2001 |
Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dietary Fats; Disease Models, Animal; Enalapril; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Lung; Magnetic Resonance Imaging; Male; Monocrotaline; Nitrates; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Perfusion; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2001 |
Decrease in the Ca2+-activated K+ current of pulmonary arterial smooth muscle in pulmonary hypertension rats.
Topics: Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Egtazic Acid; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Nisoldipine; Patch-Clamp Techniques; Peptides; Potassium Channels; Rats; Rats, Wistar | 2001 |
Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension.
Topics: Animals; Cell Transplantation; Cells, Cultured; Disease Models, Animal; Endothelial Growth Factors; Fluorescent Dyes; Gene Transfer Techniques; Genetic Therapy; Hypertension, Pulmonary; Lung; Lymphokines; Microcirculation; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Circulation; Rats; Rats, Inbred F344; Transplantation, Isogeneic; Treatment Outcome; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
5-HT1B receptor augmented 5-HT vasoconstrictor response of pulmonary artery in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; RNA, Messenger; Serotonin; Vasoconstriction | 2001 |
Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension.
Topics: Animals; Disease Progression; Hypertension, Pulmonary; Hypoxia; Male; Matrix Metalloproteinase 2; Models, Animal; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction | 2001 |
All-trans retinoic acid in pulmonary vascular structural remodeling in rats with pulmonary hypertension induced by monocrotaline.
Topics: Animals; Blood Pressure; Hydroxyproline; Hypertension, Pulmonary; Lung; Male; Matrix Metalloproteinase 1; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tretinoin | 2001 |
Defective intracellular calcium handling in monocrotaline-induced right ventricular hypertrophy: protective effect of long-term endothelin-A receptor blockade with 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy-phenyl-)- 4-oxobut-2-enoate-sodium (PD 155080
Topics: Aequorin; Animals; Calcium; Calcium Signaling; Dioxoles; Endothelin Receptor Antagonists; Endothelin-1; Female; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Luminescent Measurements; Monocrotaline; Myocardial Contraction; Perfusion; Poisons; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Ventricular Function, Right | 2002 |
Changes in alpha(1)-adrenergic vascular reactivity in monocrotaline-treated rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Mesenteric Arteries; Monocrotaline; Norepinephrine; Piperazines; Pulmonary Artery; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Thoracic Arteries; Vasoconstriction | 2002 |
Therapeutic effects of DCDDP, a calcium channel blocker, on chronic pulmonary hypertension in rat.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Division; Cells, Cultured; Chronic Disease; Dicarboxylic Acids; Dihydropyridines; Endothelins; Hemodynamics; Hypertension, Pulmonary; Male; Malondialdehyde; Monocrotaline; Muscle, Smooth, Vascular; Nitrendipine; Nitric Oxide; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Serotonin; Superoxide Dismutase; Vasoconstriction | 2002 |
The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Cardiopulmonary Bypass; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoproterenol; Male; Monocrotaline; Nitroglycerin; Propranolol; Rabbits; Vasoactive Intestinal Peptide; Vasodilator Agents; Verapamil | 2002 |
Suppressive effect of pulmonary hypertension and leukocyte activation by inhaled prostaglandin E1 in rats with monocrotaline-induced pulmonary hypertension.
Topics: Administration, Inhalation; Alprostadil; Animals; Disease Models, Animal; Drug Administration Schedule; Hypertension, Pulmonary; L-Selectin; Leukocytes; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2002 |
Fibrin thrombosis in monocrotaline pyrrole-induced cor pulmonale in rats.
Topics: Animals; Cardiomegaly; Endothelium; Fibrin; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Embolism; Pulmonary Heart Disease; Pyrroles; Pyrrolizidine Alkaloids; Rats | 1977 |
Changes in ventricular 1,2-diacylglycerol content in rats following monocrotaline treatment.
Topics: Animals; Cardiomegaly; Diglycerides; DNA; Fatty Acids; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Lipid Metabolism; Male; Monocrotaline; Myocardium; Osmolar Concentration; Rats; Rats, Wistar; RNA | 1992 |
Monocrotaline-induced structural remodeling of the intra-acinar pulmonary arteries and pulmonary hypertension.
Topics: Animals; Arterioles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Alveoli; Pulmonary Artery; Rats; Rats, Wistar | 1992 |
PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model.
Topics: Animals; Azepines; Blood Pressure; Hydroxyproline; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Artery; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thymidine; Triazoles | 1992 |
Single lung transplantation in rats with fatal pulmonary hypertension.
Topics: Animals; Cardiac Output; Cardiomegaly; Exercise Test; Follow-Up Studies; Hypertension, Pulmonary; Lung Transplantation; Male; Monocrotaline; Oxygen Consumption; Postoperative Complications; Pulmonary Edema; Rats; Rats, Inbred Lew; Time Factors; Transplantation, Isogeneic | 1992 |
[Changes in acetylcholine and acetylcholinesterase in blood during pulmonary hypertension].
Topics: Acetylcholine; Acetylcholinesterase; Animals; Female; Humans; Hypertension, Pulmonary; Lung Diseases, Obstructive; Male; Monocrotaline; Pulmonary Heart Disease; Rats; Rats, Wistar; Tobacco Smoke Pollution | 1992 |
Analysis of factors in hypertension: change of membrane fluidity in the arteries of spontaneously hypertensive and monocrotaline-injected rats.
Topics: Animals; Arteries; Hypertension; Hypertension, Pulmonary; Hypoxia, Brain; Membrane Fluidity; Monocrotaline; Phospholipases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spectrophotometry, Infrared | 1992 |
The preventive effect of radix Salciae miltiorrhizae on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Cardiomegaly; Drug Combinations; Drugs, Chinese Herbal; Female; Hypertension, Pulmonary; Male; Monocrotaline; Phenanthrolines; Plant Extracts; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 1992 |
Angiotensin II and monocrotaline-induced pulmonary hypertension: effect of losartan (DuP 753), a nonpeptide angiotensin type 1 receptor antagonist.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Body Weight; Hypertension, Pulmonary; Imidazoles; Losartan; Male; Monocrotaline; Pressoreceptors; Rats; Rats, Inbred Strains; Renin; Tetrazoles | 1992 |
Inhibition of deoxyribonucleic acid synthesis by difluoromethylornithine. Role of polyamine metabolism in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Biogenic Polyamines; Blood Pressure; DNA; DNA Replication; Eflornithine; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Ornithine; Rats; Rats, Inbred Strains; Thymidine | 1992 |
Single lung transplantation in rats with chemically induced pulmonary hypertension.
Topics: Animals; Cardiomegaly; Exercise Test; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung Transplantation; Male; Monocrotaline; Oxygen Consumption; Rats; Rats, Inbred Lew | 1992 |
Changes in contractile and non-contractile proteins, intracellular Ca2+ and ultrastructures during the development of right ventricular hypertrophy and failure in rats.
Topics: Animals; Calcium; Cardiomegaly; Collagen; Heart Failure; Hypertension, Pulmonary; Male; Microscopy, Electron, Scanning; Mitochondria, Heart; Monocrotaline; Myocardial Contraction; Myocardium; Myosins; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum | 1992 |
Role of endogenous ANP in sodium excretion in rats with experimental pulmonary hypertension.
Topics: Animals; Atrial Natriuretic Factor; Hypertension, Pulmonary; Immune Sera; Male; Monocrotaline; Natriuresis; Rats; Rats, Inbred Strains; Thiorphan | 1992 |
The rat is a poor animal model for the study of human pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats | 1992 |
Responses to vasodilator drugs on pulmonary artery preparations from pulmonary hypertensive rats.
Topics: Animals; Aorta; Hypertension, Pulmonary; Male; Monocrotaline; Oxygen; Pulmonary Artery; Rats; Rats, Inbred Strains; Vasodilator Agents | 1992 |
Increased pulmonary artery elastolytic activity in adult rats with monocrotaline-induced progressive hypertensive pulmonary vascular disease compared with infant rats with nonprogressive disease.
Topics: Age Factors; Animals; Collagen; Elastin; Hypertension, Pulmonary; Hypertrophy; Male; Monocrotaline; Pancreatic Elastase; Pulmonary Artery; Rats; Rats, Inbred Strains | 1992 |
Increased relaxation by felodipine on pulmonary artery from rats with monocrotaline-induced pulmonary hypertension does not reflect functional impairment of the endothelium.
Topics: Animals; Drug Interactions; Endothelins; Endothelium, Vascular; Felodipine; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Pulmonary Artery; Rats; Rats, Inbred Strains; Serotonin | 1991 |
Effects of single-lung transplantation on chemically induced pulmonary hypertension in the rat.
Topics: Animals; Cardiomegaly; Hypertension, Pulmonary; Lung Transplantation; Monocrotaline; Oxygen Consumption; Physical Exertion; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Lew | 1991 |
Pulmonary peptides, norepinephrine and endocrine cells in monocrotaline pulmonary hypertension.
Topics: Animals; Bombesin; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; Monocrotaline; Neuropeptides; Neurosecretory Systems; Neurotensin; Norepinephrine; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Ubiquitin Thiolesterase | 1991 |
Altered myocardial acetylcholine and norepinephrine concentrations in right ventricular hypertrophy and failure.
Topics: Acetylcholine; Animals; Cardiomegaly; Heart; Heart Failure; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Myocardial Contraction; Norepinephrine; Rats; Rats, Inbred Strains | 1991 |
PAF antagonists inhibit monocrotaline-induced lung injury and pulmonary hypertension.
Topics: Animals; Azepines; Cardiomegaly; Hypertension, Pulmonary; Lung; Lung Injury; Male; Monocrotaline; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Influence of hypobaric hypoxia in infancy on the subsequent development of vasoconstrictive pulmonary vascular disease in the Wistar albino rat.
Topics: Adult; Animals; Arterioles; Atmospheric Pressure; Constriction, Pathologic; Decompression; Female; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Male; Monocrotaline; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1991 |
Ventilatory dysfunction precedes pulmonary vascular changes in monocrotaline-treated rats.
Topics: Airway Resistance; Animals; Hypertension, Pulmonary; Lung Compliance; Male; Monocrotaline; Pulmonary Circulation; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Respiratory Mechanics; Time Factors | 1991 |
[Relation of intra-acinar arteries and their regression with changes of pulmonary artery pressure and blood gas values].
Topics: Animals; Blood Pressure; Carbon Dioxide; Hypertension, Pulmonary; Macaca mulatta; Monocrotaline; Muscle, Smooth, Vascular; Oxygen; Pulmonary Artery | 1991 |
Inhibition of elastolysis by SC-37698 reduces development and progression of monocrotaline pulmonary hypertension.
Topics: Animals; Chlorobenzoates; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Male; Microscopy, Electron, Scanning; Monocrotaline; Muscle, Smooth, Vascular; Myocardium; Organ Size; Pancreatic Elastase; Pulmonary Artery; Rats; Rats, Inbred Strains | 1991 |
Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension.
Topics: Acetylcholine; Animals; Endothelins; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Peptides; Potassium Chloride; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin | 1990 |
Ca2(+)-induced contraction and hyperreactivity of pulmonary arterial smooth muscle in monocrotaline-treated rats.
Topics: Animals; Calcium Chloride; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Chloride; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Regression Analysis; Serotonin; Vasoconstriction | 1990 |
Comparison of the hemodynamic effects of nitric oxide and endothelium-dependent vasodilators in intact lungs.
Topics: Acetylcholine; Animals; Bradykinin; Cyclic GMP; Endothelium, Vascular; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Lung; Male; Methylene Blue; Monocrotaline; Nitric Oxide; Pulmonary Circulation; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Vasodilation | 1990 |
Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrrole.
Topics: Animals; Biomarkers; Body Weight; Bronchoalveolar Lavage Fluid; Dimethylformamide; Hemodynamics; Hypertension, Pulmonary; Injections, Intravenous; L-Lactate Dehydrogenase; Lung; Male; Monocrotaline; Organ Size; Proteins; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Time Factors | 1990 |
Monokine-induced lung injury in rats: similarities to monocrotaline-induced pneumotoxicity.
Topics: Animals; Biological Factors; Cells, Cultured; Endothelium, Vascular; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Monokines; Organ Size; Ornithine Decarboxylase; Perfusion; Pulmonary Edema; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serum Albumin | 1989 |
SC-39026, a serine elastase inhibitor, prevents muscularization of peripheral arteries, suggesting a mechanism of monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Arteries; Chlorobenzoates; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pancreatic Elastase; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats | 1989 |
Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Hypertension, Pulmonary; Indomethacin; Isosorbide Dinitrate; Lung; Male; Monocrotaline; Pancreatic Elastase; Plants, Toxic; Prednisolone; Pulmonary Circulation; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio | 1989 |
[Effects of various doses of monocrotaline administration on the development of pulmonary hypertension and its regression in rats].
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Systole | 1989 |
Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline-treated rats.
Topics: Animals; Collagen; Extracellular Matrix; Hypertension, Pulmonary; Inflammation; Male; Microscopy, Electron; Monocrotaline; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1989 |
Polyamine synthesis blockade in monocrotaline-induced pneumotoxicity.
Topics: Animals; Biogenic Polyamines; Body Weight; Eflornithine; Heart; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1989 |
Polyamines and epidermal growth factor in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Epidermal Growth Factor; Hypertension, Pulmonary; Immunohistochemistry; Infusions, Intravenous; Male; Monocrotaline; Plants, Toxic; Polyamines; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio | 1989 |
Right ventricular performance after monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiomegaly; Heart; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Myocardium; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1989 |
Supplemental oxygen reduces right ventricular hypertrophy in monocrotaline-injected rats.
Topics: Animals; Cardiomegaly; Hypertension, Pulmonary; Hypoxia; Lung Injury; Male; Monocrotaline; Oxygen Inhalation Therapy; Plants, Toxic; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio | 1989 |
Strain differences in pulmonary hypertensive response to monocrotaline alkaloid and the beneficial effect of oral magnesium treatment.
Topics: Animals; Cardiomegaly; Hypertension, Pulmonary; Magnesium; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Species Specificity; Weight Gain | 1989 |
Pathological analysis of the right ventricular hypertrophy and ventricular interdependence in autopsied hearts with cor pulmonale and pulmonary hypertensive rat hearts.
Topics: Adult; Aged; Animals; Blood Pressure; Cardiomegaly; Female; Heart; Heart Septum; Heart Ventricles; Humans; Hypertension, Pulmonary; Male; Middle Aged; Monocrotaline; Myocardium; Organ Size; Pulmonary Heart Disease; Pulmonary Wedge Pressure; Pyrrolizidine Alkaloids; Rats | 1989 |
Enhanced activity of the cardiac endocrine system during right ventricular hypertrophy.
Topics: Animals; Atrial Natriuretic Factor; Autoradiography; Cardiomegaly; Hypertension, Pulmonary; Immunoblotting; Male; Monocrotaline; Myocardium; Pyrrolizidine Alkaloids; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; RNA, Messenger | 1989 |
Effects of altered platelet number on pulmonary hypertension and platelet sequestration in monocrotaline pyrrole-treated rats.
Topics: Animals; Blood Platelets; Body Weight; Dimethylformamide; Hemoglobins; Hypertension, Pulmonary; Indium Radioisotopes; Injections, Intravenous; Lung; Male; Monocrotaline; Platelet Count; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Splenectomy | 1989 |
Arachidonic acid metabolites and the mechanisms of monocrotaline pneumotoxicity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Hypertension, Pulmonary; Leukotriene B4; Lung; Monocrotaline; Pyrrolizidine Alkaloids; Rats; SRS-A; Thromboxane A2 | 1987 |
Vascular hyperresponsiveness in perfused lungs from monocrotaline-treated rats.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Perfusion; Pulmonary Artery; Pulmonary Circulation; Pulmonary Edema; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Vasoconstriction | 1986 |
Thromboxane does not mediate pulmonary vascular response to monocrotaline pyrrole.
Topics: Animals; Cyclooxygenase Inhibitors; Dibenzothiepins; Hypertension, Pulmonary; Ibuprofen; Imidazoles; Male; Monocrotaline; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Pyrrolizidine Alkaloids; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane-A Synthase; Thromboxanes | 1987 |
Echocardiographic detection of pulmonary hypertension in anesthetized rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Echocardiography; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1988 |
Plasma and atrial levels of atrial natriuretic peptide (ANP) in pulmonary hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Heart; Heart Atria; Hypertension, Pulmonary; Male; Monocrotaline; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1988 |
Pulmonary platelet sequestration is increased following monocrotaline pyrrole treatment of rats.
Topics: Animals; Blood Platelets; Cardiomegaly; Cell Survival; Hemoglobins; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 1988 |
Magnesium aspartate hydrochloride attenuates monocrotaline-induced pulmonary artery hypertension in rats.
Topics: Animals; Aspartic Acid; Blood Pressure; Cardiomegaly; Hypertension, Pulmonary; Magnesium; Male; Monocrotaline; Organ Size; Plants, Toxic; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio | 1988 |
Hypotensive response to atrial natriuretic factor in conscious chronic pulmonary hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Hypertension, Pulmonary; Male; Monocrotaline; Peptide Fragments; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1988 |
Monocrotaline-induced cardiopulmonary injury in rats: modification by thiol and nonthiol ACE inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Cardiomegaly; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Organ Size; Peptidyl-Dipeptidase A; Pyrrolizidine Alkaloids; Rats; Sulfhydryl Compounds | 1987 |
Altered pulmonary vascular smooth muscle responsiveness in monocrotaline-induced pulmonary hypertension.
Topics: Acetylcholine; Angiotensin II; Animals; Dose-Response Relationship, Drug; Hypertension, Pulmonary; In Vitro Techniques; Isoproterenol; Male; Monocrotaline; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Vasoconstriction | 1986 |
Low-dose PGI2 prevents monocrotaline-induced thromboxane production and lung injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Cell Count; Blood Platelets; Body Water; Dogs; Epoprostenol; Hemodynamics; Hypertension, Pulmonary; Lung; Lung Injury; Monocrotaline; Pyrrolizidine Alkaloids; Thrombocytopenia; Thromboxane B2 | 1986 |
The platelet thromboxane inhibitor, dazmegrel, does not reduce monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Platelets; Hypertension, Pulmonary; Imidazoles; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Thromboxanes | 1986 |
Measurement of three-dimensional anatomy and function of pulmonary arteries with high-speed x-ray computed tomography.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiac Volume; Dogs; Functional Residual Capacity; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Pyrrolizidine Alkaloids; Tomography, X-Ray Computed; Total Lung Capacity; Vascular Resistance | 1987 |
6-keto prostaglandin F1 alpha and thromboxane B2 in isolated, buffer-perfused lungs from monocrotaline pyrrole-treated rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Body Weight; Hydrostatic Pressure; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Organ Size; Perfusion; Pyrrolizidine Alkaloids; Rats; Thromboxane B2; Time Factors | 1987 |
Changes in main pulmonary artery of rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Hypertension, Pulmonary; Liver; Male; Microscopy, Electron; Monocrotaline; Muscle, Smooth, Vascular; Plants, Toxic; Pulmonary Artery; Pulmonary Wedge Pressure; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio; Time Factors | 1987 |
[The mechanism of the development of pulmonary hypertension induced by monocrotaline in rats].
Topics: Animals; Hypertension, Pulmonary; In Vitro Techniques; Monocrotaline; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1987 |
Altered elastin and collagen synthesis associated with progressive pulmonary hypertension induced by monocrotaline. A biochemical and ultrastructural study.
Topics: Animals; Aorta; Collagen; Elastin; Endothelium, Vascular; Hypertension, Pulmonary; Male; Microscopy, Electron; Monocrotaline; Plants, Toxic; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Senecio | 1988 |
Interleukin 1 bioactivity in the lungs of rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Bronchoalveolar Lavage Fluid; Hypertension, Pulmonary; Interleukin-1; Kinetics; Lung; Male; Monocrotaline; Pneumonia; Pulmonary Edema; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1988 |
Pulmonary vascular responses induced by the pyrrolizidine alkaloid, monocrotaline, in rats.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Male; Monocrotaline; Norepinephrine; Organ Size; Pulmonary Circulation; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin; Vasoconstriction | 1987 |
[Effect of hydralazine on the pulmonary arterial hypertension in monocrotaline induced cor pulmonale in Macacus rhesus].
Topics: Animals; Arterioles; Hydralazine; Hypertension, Pulmonary; Lung; Macaca mulatta; Monocrotaline; Pulmonary Heart Disease; Pyrrolizidine Alkaloids | 1987 |
Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension.
Topics: Animals; Blood Pressure; Body Weight; Carbon Dioxide; Endothelium, Vascular; Heart Ventricles; Hematocrit; Hypertension, Pulmonary; Male; Monocrotaline; Organ Size; Oxygen; Partial Pressure; Plants, Toxic; Pulmonary Artery; Pulmonary Circulation; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio; Vascular Resistance | 1988 |
Altered artery mechanics and structure in monocrotaline pulmonary hypertension.
Topics: Animals; Biomechanical Phenomena; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Muscle Contraction; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Vascular Resistance | 1988 |
Polyamine content in pulmonary arteries from rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Polyamines; Pulmonary Artery; Putrescine; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Spermidine; Spermine | 1988 |
Effect of methylprednisolone on monocrotaline-induced pulmonary vascular disease and right ventricular hypertrophy.
Topics: Animals; Body Weight; Cardiomegaly; Heart Ventricles; Hypertension, Pulmonary; Male; Methylprednisolone; Monocrotaline; Pulmonary Heart Disease; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1985 |
Pulmonary hypertension induced in rats by monocrotaline and chronic hypoxia is reduced by p-chlorophenylalanine.
Topics: Animals; Chronic Disease; Female; Fenclonine; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin | 1985 |
Pulmonary hypertension due to monocrotaline pyrrole is reduced by moderate thrombocytopenia.
Topics: Animals; Blood Platelets; Blood Pressure; Hypertension, Pulmonary; Immunization, Passive; L-Lactate Dehydrogenase; Male; Monocrotaline; Platelet-Derived Growth Factor; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Thrombocytopenia | 1988 |
6-Ketoprostaglandin F1 alpha and thromboxane B2 in isolated, blood-perfused lungs from monocrotaline pyrrole-treated rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Thromboxane B2 | 1988 |
Complement is not involved in monocrotaline pyrrole-induced pulmonary injury.
Topics: Animals; Complement Activation; Dimethylformamide; Elapid Venoms; Hemolysis; Hypertension, Pulmonary; Isoenzymes; L-Lactate Dehydrogenase; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1988 |
5-Hydroxytryptamine and thromboxane in platelets from rats treated with monocrotaline pyrrole.
Topics: Animals; Blood Platelets; Hypertension, Pulmonary; Male; Monocrotaline; Platelet Aggregation; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin; Thromboxane B2; Thromboxanes; Time Factors | 1987 |
The effect of immunosuppressants and adoptive transfer in monocrotaline pyrrole pneumotoxicity.
Topics: Animals; Antilymphocyte Serum; Body Weight; Bronchoalveolar Lavage Fluid; Cyclosporins; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy; Immunization, Passive; Immunosuppressive Agents; L-Lactate Dehydrogenase; Lung; Lymphocytes; Male; Monocrotaline; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1987 |
Elevated serum copper concentration in monocrotaline pyrrole treated rats with pulmonary hypertension.
Topics: Animals; Copper; Hypertension, Pulmonary; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1987 |
Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Biological Assay; Diethylcarbamazine; Enzyme Activation; Guinea Pigs; Hypertension, Pulmonary; Indomethacin; Leukocyte Count; Lipoxygenase; Male; Monocrotaline; Muscle Contraction; Pneumonia; Prostaglandin-Endoperoxide Synthases; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; SRS-A; Therapeutic Irrigation; Thromboxane B2; Time Factors | 1985 |
Pulmonary mechanical, ventilatory, and gas exchange abnormalities in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Gas Analysis; Hypertension, Pulmonary; Lung; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Respiration; Tidal Volume | 1985 |
[Monocrotaline-induced pulmonary hypertension with special reference to the influence of dose, age, and sex].
Topics: Age Factors; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypertension, Pulmonary; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Sex Factors | 1985 |
[Mast cell hyperplasia in monocrotaline-induced pulmonary changes in rats].
Topics: Animals; Cell Count; Histamine; Hyperplasia; Hypertension, Pulmonary; Lung; Male; Mast Cells; Monocrotaline; Pulmonary Fibrosis; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1985 |
[Reduction of the development of monocrotaline-induced pulmonary hypertension in rats by artificial unilateral pneumothorax].
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline; Pneumothorax, Artificial; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1985 |
Increased vascular responsiveness in lungs of rats with pulmonary hypertension induced by monocrotaline pyrrole.
Topics: Angiotensin II; Animals; Blood Vessels; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Male; Monocrotaline; Perfusion; Pulmonary Circulation; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin | 1985 |