monocrotaline and Heritable Pulmonary Arterial Hypertension

Topics: Adult; Aged; Animals; Benzamides; Cell Division; Dichloroacetic Acid; Disease Models, Animal; Drug Monitoring; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Gene Expression Profiling; Glycolysis; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Indoles; Lung; Male; Middle Aged; Monocrotaline; Piperazines; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sunitinib; Young Adult

Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fasting; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right; Ventricular Function, Right

Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Glucosides; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Sildenafil Citrate; Vascular Remodeling

Topics: Animals; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Humans; Monocrotaline; Protein-Tyrosine Kinases; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats

Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Imatinib Mesylate; MicroRNAs; Monocrotaline; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats

Topics: Animals; Atrial Natriuretic Factor; Cytokine Receptor gp130; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fibrosis; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammasomes; Macrophage Activation; Macrophages; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Pulmonary Arterial Hypertension; Rats; Ventricular Dysfunction, Right

Topics: Animals; Cell Proliferation; Familial Primary Pulmonary Hypertension; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Hypertension, Pulmonary; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; RNA; RNA-Binding Proteins

Topics: Animals; Antioxidants; Arginine Vasopressin; Cysteine; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hepatocyte Growth Factor; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Malondialdehyde; Melatonin; Monocrotaline; NF-E2-Related Factor 2; Proto-Oncogene Proteins; Pulmonary Arterial Hypertension; Rats; RNA, Small Interfering; Ventricular Remodeling

Topics: Actins; Animals; Autophagy; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Forkhead Box Protein M1; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Ki-67 Antigen; Monocrotaline; Phosphorylation; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley

Topics: Animals; Arrhythmias, Cardiac; Connexin 43; Disease Models, Animal; Endothelin-1; Familial Primary Pulmonary Hypertension; Monocrotaline; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rabbits

Topics: Angiotensin II; Animals; Antagomirs; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Mice; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Up-Regulation; Ventricular Remodeling

Topics: Animals; Cellular Senescence; Endothelial Cells; Familial Primary Pulmonary Hypertension; Forkhead Transcription Factors; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Senotherapeutics

Topics: Animals; Cell Transdifferentiation; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Glycogen Synthase Kinase 3 beta; Hypertension, Pulmonary; Male; Monocrotaline; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Signal Transduction

Topics: Animals; Familial Primary Pulmonary Hypertension; Fibronectins; Monocrotaline; Pulmonary Arterial Hypertension; Receptors, Notch; Serrate-Jagged Proteins; Up-Regulation; Vimentin

Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Minocycline; Monocrotaline; Neuroinflammatory Diseases; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Spinal Cord

Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Heat-Shock Proteins; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Vascular Remodeling

Topics: Animals; Antioxidants; Biological Availability; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Nitric Oxide; Oils, Volatile; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Wistar

Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fibrosis; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling

Topics: Animals; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Interleukin-11; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; RNA, Small Interfering

Topics: Adult; Animals; Biomarkers; Case-Control Studies; China; Chromatography, High Pressure Liquid; Discriminant Analysis; Familial Primary Pulmonary Hypertension; Fatty Acids; Female; Humans; Lipid Metabolism; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Monocrotaline; Rats; Rats, Sprague-Dawley

Topics: Animals; Cell Line; Cell Proliferation; Familial Primary Pulmonary Hypertension; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; rho-Associated Kinases; Up-Regulation; Vascular Remodeling

Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors

Topics: Actins; Adult; Animals; Antibodies, Neutralizing; Becaplermin; Case-Control Studies; Cell Dedifferentiation; Cell Proliferation; Collagen Type I; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Fibronectins; Gene Expression Regulation; Homeostasis; Humans; Integrin beta1; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mice; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Nuclear Proteins; Pulmonary Artery; Rats; Receptors, Platelet-Derived Growth Factor; RNA, Small Interfering; Signal Transduction; Tissue Culture Techniques; Trans-Activators

Topics: Animals; Autophagy; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hemodynamics; Histone-Lysine N-Methyltransferase; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling

Topics: Animals; Cell Line; Cyclin-Dependent Kinases; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Indoles; Lung; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Piperazines; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Pyrroles; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Treatment Outcome

Topics: Adult; Animals; Biomarkers; Case-Control Studies; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Hypoxia; Male; Metabolomics; Methionine; Monocrotaline; Rats, Sprague-Dawley; Urea

Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Codon, Nonsense; Epoprostenol; Familial Primary Pulmonary Hypertension; HEK293 Cells; Humans; Hypertension, Pulmonary; Lung; Male; MAP Kinase Signaling System; Mice; Monocrotaline; Myocytes, Smooth Muscle; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Smad3 Protein; Transforming Growth Factor beta1

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cholesterol, HDL; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Natriuretic Peptide, Brain; Phosphodiesterase 5 Inhibitors; Piperazines; Protein Kinase Inhibitors; Purines; Rats; Rats, Wistar; rho-Associated Kinases; Sildenafil Citrate; Sulfones; Vascular Endothelial Growth Factor A

Topics: Acetylation; Animals; Butyric Acid; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Chromones; Familial Primary Pulmonary Hypertension; Gene Expression; Histone Deacetylase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Morpholines; Myocytes, Smooth Muscle; Phosphorylation; Platelet-Derived Growth Factor; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Tissue Culture Techniques

Topics: Adult; Aged; Animals; Apoptosis; Arterial Pressure; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Glycation End Products, Advanced; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; S100 Proteins; Signal Transduction; STAT3 Transcription Factor; Transfection; Up-Regulation

Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Arterial Pressure; Caveolin 1; Endothelium, Vascular; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Interleukin-1beta; Male; Monocrotaline; NF-kappa B; Nitric Oxide Synthase Type III; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley; Spirostans; Thromboplastin

Topics: Animals; Antioxidants; Disease Models, Animal; Endothelium, Vascular; Erythrocytes; Familial Primary Pulmonary Hypertension; Hematocrit; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates

Topics: Animals; Antihypertensive Agents; Apoptosis; Benzamides; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Feedback, Physiological; Fibroblast Growth Factor 2; Hypertension, Pulmonary; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors; Tissue Plasminogen Activator; Transcription Factor RelA; Ventricular Function, Right; Ventricular Pressure

Topics: Adolescent; Adult; Animals; Case-Control Studies; Cell Proliferation; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Imidazoles; Male; Monocrotaline; Nitric Oxide; Oxidative Stress; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sulfones; Triazines; Vardenafil Dihydrochloride; Young Adult

Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Arterial Pressure; Cytoprotection; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Naphthalenes; Neointima; Peptide Fragments; Peptidyl-Dipeptidase A; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Resorcinols; Severity of Illness Index; Time Factors; Vasodilation

Topics: Adaptation, Physiological; Animals; Arteriovenous Shunt, Surgical; Constriction; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Heart Failure; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Models, Cardiovascular; Monocrotaline; Myocardial Contraction; Physical Exertion; Pulmonary Artery; Rats; Rats, Wistar; Stroke Volume; Time Factors; Ultrasonography; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure

Topics: Animals; Cells, Cultured; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Gene Transfer Techniques; Heart Ventricles; HEK293 Cells; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Random Allocation; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Treatment Outcome

Topics: Animals; Cyclooxygenase 1; Cytochrome P-450 Enzyme System; Disease Models, Animal; Endothelial Cells; Epoprostenol; Familial Primary Pulmonary Hypertension; Genetic Therapy; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Infusions, Intravenous; Intramolecular Oxidoreductases; Male; Monocrotaline; Rats; Rats, Inbred F344; Stem Cell Transplantation; Survival Rate; Tissue Engineering; Transfection; Treatment Outcome

Topics: Animals; Bone Marrow Cells; Cell Transplantation; Dogs; Familial Primary Pulmonary Hypertension; Female; Hypertension, Pulmonary; Leukocytes, Mononuclear; Male; Monocrotaline; Rats

Topics: Animals; Apoptosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Lineage; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Mice; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Phenotype; RNA, Messenger; Stem Cells; Time Factors; Transport Vesicles

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Male; Monocrotaline; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Treatment Outcome

Topics: Animals; Arginine; Arterial Pressure; Biomarkers; Biopterins; Exhalation; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide; Pneumonectomy; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley

Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; bcl-2-Associated X Protein; Caspase 3; Cell Cycle Checkpoints; Cell Line; Colchicine; Connexin 43; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Heart Ventricles; Hypertension, Pulmonary; Lung; Male; Matrix Metalloproteinase 9; Monocrotaline; Myocytes, Smooth Muscle; NF-kappa B; Nicorandil; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Smad3 Protein; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

Topics: Animals; Bone Marrow Cells; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Lung; Monocrotaline; Stem Cells; Transport Vesicles

Topics: Adult; Aged; Animals; Apoptosis; Benzimidazoles; Cell Proliferation; Cells, Cultured; Disease Models, Animal; DNA Damage; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Male; MicroRNAs; Middle Aged; Monocrotaline; NFATC Transcription Factors; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Signal Transduction

Topics: Animals; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Fenclonine; Hypertension, Pulmonary; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Phenylalanine; Pneumonia; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tryptophan Hydroxylase; Tumor Necrosis Factor-alpha

Topics: Adenoviridae; Animals; Arterial Pressure; Cells, Cultured; Chemokine CCL2; Chemokines, CXC; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Female; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages; Monocrotaline; Neutrophil Infiltration; Neutrophils; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovariectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-8; Transduction, Genetic; Up-Regulation; Ventricular Function, Right; Ventricular Remodeling

Topics: Adult; Aged, 80 and over; Animals; Antihypertensive Agents; Case-Control Studies; Cell Hypoxia; Cells, Cultured; Collagen; Disease Models, Animal; Elastin; Enzyme Inhibitors; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Isoenzymes; Male; Mice; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein-Lysine 6-Oxidase; Pulmonary Artery; Rats; RNA, Messenger; Ventricular Dysfunction, Right; Young Adult

Topics: Adventitia; Animals; Antihypertensive Agents; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fibroblasts; HEK293 Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection; Up-Regulation

Topics: Animals; Endothelial Cells; Familial Primary Pulmonary Hypertension; Female; Genetic Therapy; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Receptors, Interleukin-8

Topics: Angiotensin II; Animals; Blood Pressure; Denervation; Dogs; Echocardiography; Endothelin-1; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Kidney; Lung; Monocrotaline; Pulmonary Artery; Sympathectomy; Vascular Remodeling

Topics: Animals; Case-Control Studies; Cell-Derived Microparticles; Cells, Cultured; Disease Models, Animal; Exosomes; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Pulmonary Artery; Vascular Remodeling

Topics: Animals; Arterioles; Familial Primary Pulmonary Hypertension; GTP-Binding Protein alpha Subunits, Gq-G11; Hypertension, Pulmonary; Lung; Monocrotaline; Muscle, Smooth, Vascular; Osteopontin; Piperazines; Random Allocation; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Familial Primary Pulmonary Hypertension; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Piperazines; Pulmonary Artery; Purines; Rats; Sildenafil Citrate; Sulfonamides; Sulfones; Vasodilator Agents

Topics: Animals; Anti-Inflammatory Agents; Bone Morphogenetic Protein Receptors; Cell Proliferation; Dexamethasone; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Immunohistochemistry; Interleukin-6; Lung; Male; Monocrotaline; Muscle, Smooth; Rats; Rats, Wistar; Treatment Outcome

Topics: Animals; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Matrix Metalloproteinases; Monocrotaline; RNA, Small Interfering; Tissue Inhibitor of Metalloproteinases

Topics: Animals; Cytokines; Disease Models, Animal; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fluoxetine; Hypertension, Pulmonary; Inflammation; Lung; Male; Matrix Metalloproteinase Inhibitors; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Tissue Inhibitor of Metalloproteinases

Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; C-Reactive Protein; Constriction, Pathologic; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Hemodynamics; Hepatocyte Growth Factor; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Platelet-Derived Growth Factor; Pulmonary Artery; Rats; Rats, Wistar; Recombinant Proteins; Survival Analysis

Topics: Angiotensin I; Animals; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type III; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley

Topics: Animals; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Organ Size; Peptide Fragments; Pulmonary Artery; Rats; Rats, Wistar; Urotensins; Vasodilation

Topics: Animals; Arteries; Cell Movement; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kaplan-Meier Estimate; Monocrotaline; Rats; Rats, Nude; Stem Cell Transplantation; Stem Cells; Ventricular Remodeling

Topics: Animals; Blood Pressure; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Dexamethasone; Familial Primary Pulmonary Hypertension; Glucocorticoids; Hypertension, Pulmonary; Interferon-gamma; Interleukin-4; Lung; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar; Receptors, Chemokine

Topics: Animals; Cell Degranulation; Cromolyn Sodium; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mast Cells; Monocrotaline; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Rats; Rats, Sprague-Dawley; Ventricular Function, Right; Ventricular Remodeling

Topics: Animals; Cell Proliferation; Endothelial Cells; Familial Primary Pulmonary Hypertension; Fluorobenzenes; Hypertension, Pulmonary; Hypolipidemic Agents; Male; Monocrotaline; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type III; Proliferating Cell Nuclear Antigen; Pyrimidines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Rosuvastatin Calcium; Sulfonamides

Topics: Animals; Blood Coagulation; Enoxaparin; Factor Xa; Factor Xa Inhibitors; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Morpholines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Rivaroxaban; Thiophenes; Thrombosis; Warfarin

Topics: Animals; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Mice; Mice, Knockout; Monocrotaline; Mutation; Rats; Superoxide Dismutase

Topics: Animals; Etanercept; Familial Primary Pulmonary Hypertension; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypertension, Pulmonary; Immunoglobulin G; Inflammation Mediators; Ion Channel Gating; Ketone Oxidoreductases; Kv1.5 Potassium Channel; Models, Biological; Monocrotaline; Myocytes, Smooth Muscle; Phenotype; Pulmonary Artery; Rats; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha

Topics: Adult; Animals; Antihypertensive Agents; Apoptosis; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II; Calcium; Cell Proliferation; Cells, Cultured; Dehydroepiandrosterone; Disease Models, Animal; Enzyme Activation; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; In Situ Nick-End Labeling; Inhibitor of Apoptosis Proteins; Male; Membrane Potential, Mitochondrial; MicroRNAs; Microtubule-Associated Proteins; Middle Aged; Monocrotaline; Muscle, Smooth; Myocytes, Smooth Muscle; NFATC Transcription Factors; Proto-Oncogene Proteins c-pim-1; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Survivin; Vasodilator Agents

Topics: Animals; Arterioles; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood Proteins; Familial Primary Pulmonary Hypertension; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Male; Monocrotaline; Phenothiazines; Piperazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Serotonin 5-HT2 Receptor Antagonists

Topics: Animals; Ascorbic Acid; Cardiomegaly; Familial Primary Pulmonary Hypertension; Glutathione; Heart Ventricles; Hydrogen Peroxide; Hypertension, Pulmonary; Male; Monocrotaline; Oxidative Stress; Rats; Rats, Wistar; Thioredoxin-Disulfide Reductase; Ultrasonography

Topics: Animals; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Early Growth Response Protein 1; Familial Primary Pulmonary Hypertension; Heart Defects, Congenital; Hemodynamics; Humans; Hypertension, Pulmonary; Immunohistochemistry; Monocrotaline; Neointima; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Repressor Proteins

Topics: Animals; Chronic Disease; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Rats; Rats, Wistar; Tunica Media

Topics: Animals; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Monocrotaline; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Sulfonamides; Vasoactive Intestinal Peptide

Topics: Animals; Beverages; Caspase 3; Disease Models, Animal; Echocardiography; Familial Primary Pulmonary Hypertension; Hydrogen Peroxide; Hypertension, Pulmonary; Lipid Peroxidation; Male; Monocrotaline; Oxidation-Reduction; Rats; Rats, Wistar; Signal Transduction; Thioredoxins; Ventricular Remodeling; Vitis

Topics: Adolescent; Adult; Animals; Antibodies, Neutralizing; Becaplermin; Benzamides; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imatinib Mesylate; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oligopeptides; Piperazines; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptor, Platelet-Derived Growth Factor beta; RNA Interference; Signal Transduction; Time Factors; Transfection; Tryptases; Young Adult

Topics: Animals; Antihypertensive Agents; Apoptosis; Blotting, Western; Caspase 3; Cells, Cultured; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Familial Primary Pulmonary Hypertension; Glyburide; Human Umbilical Vein Endothelial Cells; Humans; Hypertension, Pulmonary; Injections, Intraperitoneal; Male; MAP Kinase Signaling System; Monocrotaline; NG-Nitroarginine Methyl Ester; Nicorandil; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction; Ventricular Pressure

Topics: Animals; Antihypertensive Agents; Case-Control Studies; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Cobalt; Cyclin B1; Disease Models, Animal; Dynamins; Enzyme Activation; Familial Primary Pulmonary Hypertension; Genetic Therapy; Glycolysis; GTP Phosphohydrolases; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microtubule-Associated Proteins; Mitochondria, Muscle; Mitochondrial Proteins; Mitosis; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pulmonary Artery; Quinazolinones; Rats; Rats, Sprague-Dawley; RNA Interference; Serine; Time Factors; Transfection

Topics: Animals; Antibodies; Blood Platelets; Blood Pressure; Bone Marrow Cells; Familial Primary Pulmonary Hypertension; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; P-Selectin; Platelet Glycoprotein GPIIb-IIIa Complex; Rats; Rats, Sprague-Dawley; Tirofiban; Tyrosine

Topics: Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Familial Primary Pulmonary Hypertension; Fluorobenzenes; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide Synthase Type III; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Time Factors

Topics: Animals; Benzenesulfonamides; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Sulfonamides; Ventricular Pressure

Topics: Aniline Compounds; Animals; Calcimimetic Agents; Calcium Signaling; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthalenes; Phenethylamines; Propylamines; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; RNA Interference; Spermine; Time Factors; Transfection; Vasoconstriction

Topics: Animals; Benzamides; Benzimidazoles; Case-Control Studies; Crk-Associated Substrate Protein; Disease Models, Animal; Endothelial Cells; Epidermal Growth Factor; Familial Primary Pulmonary Hypertension; Fibroblast Growth Factor 2; Gefitinib; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Mice; Monocrotaline; Myocytes, Smooth Muscle; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pulmonary Artery; Pyrimidines; Quinazolines; Quinolones; Rats; Signal Transduction

Topics: Animals; Annexins; Apoptosis; Blood Pressure; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Heart Ventricles; Humans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocardium; Perfusion; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Systole; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Ventricular Remodeling

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Disease Models, Animal; Etanercept; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Hypertension, Pulmonary; Immunoglobulin G; Inflammation; Lung; Male; Monocrotaline; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha

Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Case-Control Studies; Cells, Cultured; Disease Progression; Endothelium, Vascular; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Losartan; Male; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Proportional Hazards Models; Rats; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Up-Regulation

Topics: Animals; Endothelin-1; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; KATP Channels; Lung; Male; Monocrotaline; Natriuretic Peptide, Brain; Nitric Oxide; Propylamines; Rats; Rats, Wistar

Topics: Animals; Calcium; Diaphragm; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Contraction; Muscle Fibers, Skeletal; Muscle Weakness; Myosin Heavy Chains; Rats; Rats, Wistar; Sarcomeres

Topics: Animals; Antihypertensive Agents; Arterial Pressure; Arterioles; Carbolines; Disease Models, Animal; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Simvastatin; Tadalafil; Time Factors; Vasodilator Agents

Topics: Animals; Arterial Pressure; Arterioles; Endothelin-1; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Quinolines; Rats; Rats, Wistar; Transforming Growth Factor beta1; Urea; Urotensins

Topics: Animals; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Indoles; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Receptor, Serotonin, 5-HT2B; Rosiglitazone; Serotonin 5-HT2 Receptor Agonists; Thiazolidinediones; Thiophenes; Transcription Factor AP-1; Up-Regulation

Topics: Animals; Antihypertensive Agents; Binding Sites; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell Proliferation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Disease Models, Animal; Dose-Response Relationship, Drug; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Inhibitor of Differentiation Protein 1; Male; Monocrotaline; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Phosphodiesterase 5 Inhibitors; Phosphorylation; Piperazines; Promoter Regions, Genetic; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Sildenafil Citrate; Smad1 Protein; Smad5 Protein; Sulfones; Transfection; Vasodilator Agents

Topics: Airway Remodeling; Animals; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Fluoxetine; Hypertension, Pulmonary; Isoenzymes; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Selective Serotonin Reuptake Inhibitors

Topics: Animals; Cell- and Tissue-Based Therapy; Combined Modality Therapy; Endothelial Cells; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Stem Cell Transplantation; Stem Cells; Sulfones; Time; Vasodilator Agents

Topics: Acetylcholine; Animals; Benzodioxoles; Calcium Channel Blockers; Calcium Chloride; Cardiomegaly; Familial Primary Pulmonary Hypertension; Hydrazones; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Phenylephrine; Pulmonary Artery; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents