monocrotaline has been researched along with Disease Models, Animal in 540 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (1.67) | 18.7374 |
| 1990's | 35 (6.48) | 18.2507 |
| 2000's | 111 (20.56) | 29.6817 |
| 2010's | 269 (49.81) | 24.3611 |
| 2020's | 116 (21.48) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Ben Fadel, N; Deng, Y; Jankov, RP; Lesage, F; Renesme, L; Sauvestre, F; Stewart, DJ; Thébaud, B; Vadivel, A; Zhong, S | 1 |
| Brodaczewska, K; Kieda, C; Mackiewicz, U; Mączewski, M; Oknińska, M; Paterek, A; Szczylik, C; Torbicki, A; Zajda, K; Zambrowska, Z | 1 |
| Crossman, DJ; Han, JC; Howe, K; Loiselle, DS; Ross, JM | 1 |
| Chen, W; Lian, G; Luo, L; Wang, H; Wang, T; Xiao, G; Xie, L; Zhuang, W | 1 |
| Ding, D; He, Y; Jiang, H; Li, X; Liu, X; Xu, Y | 1 |
| Eklund, M; Khoruts, A; Moutsoglou, DM; Prins, KW; Prisco, AR; Prisco, SZ; Thenappan, T; Weir, EK | 1 |
| Balis, P; Doka, G; Klimas, J; Kmecova, Z; Krenek, P; Malikova, E; Pivackova, LB; Trubacova, S; Velasova, E | 1 |
| Agulham, AP; Bertoldi, AS; Gewehr, DM; Giovanini, AF; Kubrusly, FB; Kubrusly, LF; Mattar, BA; Nagashima, S | 1 |
| Gong, X; Liu, Y; Sheng, Y; Yuan, Y; Zhao, J | 1 |
| Chen, W; Chen, Z; Cheng, S; Hu, S; Li, H; Ouyang, M; Peng, H; Xue, J; Yu, S; Zeng, W; Zhang, Y; Zhou, L | 1 |
| An, L; Chu, X; L, X; Liu, X; Liu, Y; Wang, Y; Zhang, Y | 1 |
| Dai, C; Fang, J; Huang, H; Kong, B; Qin, T; Shuai, W; Xiao, Z | 1 |
| Goshima, Y; Goto, T; Hashimoto, T; Koga, M; Masukawa, D; Matsushita, N; Miyazaki, T; Mizuno, Y; Nakamura, F; Nakano, M; Niikura, R; Saito, M; Shimizu, T; Tamura, K; Uchimura, H; Zou, S | 1 |
| Chen, D; Chen, Y; Du, G; Fang, L; Niu, Z; Yuan, T; Zhang, H | 1 |
| Adekunle, AO; Adu-Amankwaah, J; Adzika, GK; Duah, M; Ma, Y; Mprah, R; Ndzie Noah, ML; Okwuma, JD; Qiao, W; Wang, C; Wowui, PI | 1 |
| Fujii, S; Fukuda, M; Kato, T; Kobayashi, S; Mikawa, M; Nakamura, Y; Nawata, J; Oda, T; Okamura, T; Okuda, S; Suetomi, T; Tanaka, S; Uchinoumi, H; Yamamoto, T; Yano, M | 1 |
| Jasińska-Stroschein, M | 1 |
| Chen, D; Du, GH; Fang, LH; Lyu, Y; Sun, SC; Wang, RR; Wang, SB; Yuan, TY; Zhang, HF | 1 |
| Adi, D; Aierken, A; Gai, MT; Li, MY; Li, Q; Uddin, MN; Wang, J; Wang, R; Wu, Y; Yan, QZ | 1 |
| Fu, Q; He, J; Li, M; Peng, J; Tan, S; Tang, M; Tang, Y; Xie, W; Xu, X; Zhang, Q; Zhang, Y; Zheng, Z; Zhu, T | 1 |
| Makino, I; Miyashita, T; Munesue, S; Nakanuma, S; Ohbatake, Y; Ohta, T; Okazaki, M; Tajima, H; Takamura, H; Yamamoto, Y; Yamazaki, H | 1 |
| Cao, Y; Chen, F; Chu, C; Fulton, D; Hu, L; Huang, H; Li, K; Li, Y; Lin, D; Qin, L; Shen, Y; Wang, J; Wang, X; Yu, Y; Zhang, H | 1 |
| Amazit, L; Berrebeh, N; Chaumais, MC; Chelgham, MK; Guignabert, C; Huertas, A; Humbert, M; Le Vely, B; Ottaviani, M; Phan, C; Thuillet, R; Tu, L | 1 |
| Han, H; He, M; Hu, S; Kong, H; Tan, Q; Wang, H; Wang, J; Wang, Y; Wu, X; Xie, W; Xu, J; Yang, M; Yu, M | 1 |
| Jiang, C; Lu, S; Ma, X; Wang, XE; Xie, LX | 1 |
| Carter, LL; Clemons, B; Douthitt, A; Galkin, A; Gandjeva, A; Garcia, E; Guimond, D; Kennedy, M; Osterhout, R; Salter-Cid, L; Sitapara, R; Slee, D; Tuder, RM; Zisman, LS | 1 |
| Al-Qazazi, R; Archer, SL; Bentley, RET; Bonnet, S; Chen, KH; Dasgupta, A; Jones, O; Lima, PDA; Martin, AY; Maurice, DH; Mewburn, J; Potus, F; Prins, KW; Prisco, SZ; Provencher, S; Tian, L; Wu, D | 1 |
| Bao, C; Chen, J; Han, Y; He, Q; Hu, Y; Liang, S; Luo, A; Nahar, T; Pan, Y; Sun, Y; Tang, H; Wang, H; Xu, Y; Zheng, S | 1 |
| Chen, T; Li, Z; Lu, D; Su, S; Yang, Z; Zhang, D | 1 |
| Feng, Y; Gao, X; Hao, X; Li, L; Long, Y; Zhang, J; Zhang, S; Zhang, X | 1 |
| Fang, C; Liu, C; Liu, K; Lv, X; Ma, Z; Wei, R | 1 |
| Chen, J; Chen, Y; Li, J; Li, Z; Luo, J; Qiu, H; Tang, Y; Yang, X | 1 |
| Guignabert, C; Humbert, M; Kolkhof, P; Lombès, M; Ottaviani, M; Perrot, J; Ponsardin, E; Thuillet, R; Tu, L; Viengchareun, S | 1 |
| Bisserier, M; Bonnet, S; Boucherat, O; Hadri, L | 1 |
| Chuang, KH; Gui, LX; Jiang, YN; Lin, MJ; Yao, RH; Zheng, SY | 1 |
| Carneiro-Júnior, MA; Drummond, FR; Ervilha, LOG; Freitas, MO; Leite, LB; Natali, AJ; Neves, MM; Portes, AMO; Reis, ECC; Rezende, LMT; Silva, BAFD; Soares, LL | 1 |
| Chen, S; Cui, H; Du, GQ; Li, Y; Shen, W; Sun, P; Wang, C; Xue, JY; Zhao, P | 1 |
| Cao, M; Li, S; Liu, H; Luan, J; Wang, J; Xue, Y; Zhai, C; Zhang, N; Zhang, Q; Zhu, Y | 1 |
| Chang, R; Cui, B; Fan, Z; Hiram, R; Huang, C; Huang, H; Liu, T; Shi, S; Su, X; Tang, Y; Wu, G; Wu, J; Xiong, F; Yan, M; Zhang, W | 1 |
| Bao, C; Chen, A; Han, Y; Liang, S; Pan, Y; Tang, H; Wang, X | 1 |
| Duarte, JA; Ferreira, R; Leite-Moreira, A; Morais, F; Moreira-Gonçalves, D; Nogueira-Ferreira, R; Rocha, H; Santos, M; Silva, AF; Vilarinho, L | 1 |
| Gu, L; Liu, CJ; Liu, HM; Xie, L; Yu, L | 1 |
| Chen, SA; Chen, YC; Chen, YJ; Higa, S; Kao, YH; Lin, FJ; Lu, YY | 1 |
| Carvalho, MR; Martinez, PF; Ogura, AY; Oliveira-Junior, SA | 1 |
| Baranowska-Kuczko, M; Kasacka, I; Kozłowska, H; Krzyżewska, A | 1 |
| Liu, Y; Nie, X; Qi, Y; Shang, J; Wu, Z; Zhu, L | 1 |
| Chen, W; Huang, T; Li, W; Liu, J; Peng, H; Song, Q; Wang, X; Xiao, Y; Xiao, Z; Zeng, Y | 1 |
| Gralinski, MR; Neves, LAA; Rosas, PC; Senese, PB | 1 |
| de Lima Conceição, MR; Leal-Silva, P; Roman-Campos, D; Teixeira-Fonseca, JL | 1 |
| Boehm, M; Bonnet, S; Bourgeois, A; Dabral, S; de Man, F; Friedrich, A; Grobs, Y; Guenther, S; Jafari, L; Janssen, W; Khassafi, F; Kojonazarov, B; Kuenne, C; Looso, M; Maroli, G; Nayakanti, SR; Provencher, S; Pullamsetti, SS; Sarode, P; Savai, R; Schermuly, RT; Seeger, W; Tello, K; Weiss, A; Wietelmann, A; Wilhelm, J | 1 |
| Ajijola, OA; Banerjee, S; Fishbein, G; Hong, J; Magaki, S; Razee, A; Umar, S | 1 |
| Fan, C; Li, J; Mei, F; Wang, S; Xi, R; Yang, J; Yin, Q; Yu, Y; Zhang, S; Zhang, X | 1 |
| Chen, L; Fan, F; Guan, Y; He, H; Liu, M; Qiu, L; Yang, G; Zheng, F | 1 |
| Balakin, AA; Gerzen, OP; Kuznetsov, DA; Lisin, RV; Mukhlynina, EA; Nikitina, LV; Protsenko, YL | 1 |
| Musch, TI; Schulze, KM | 1 |
| Araujo, ASDR; Belló-Klein, A; Campos-Carraro, C; de Lima-Seolin, BG; Teixeira, RB; Turck, P; Zimmer, A | 1 |
| Song, ZY; Tian, YN; Wang, WT; Wang, XT; Wang, XY; Xu, JP; Yuan, LB; Zhang, S | 1 |
| Bo, Y; Cui, Z; Tianxin, Y; Weiguo, W; Yi, Y; Zhangchi, L | 1 |
| Chen, J; Chen, X; Feng, J; Liu, Z; Luo, Y; Teng, X; Yan, X; Yang, S; Zhang, L; Zhao, S | 1 |
| Carlström, M; Henrohn, D; Klimas, J; Kmecova, Z; Krenek, P; Malikova, E; Marusakova, M; Zsigmondova, B | 1 |
| Cai, C; Lin, W; Wu, Y; Xiang, Y; Xu, J; Zeng, C; Zhao, H; Zhu, N | 1 |
| Feng, Q; Qian, X; Zhao, H | 1 |
| Agostini, F; Bahr, A; Belló-Klein, A; Campos-Carraro, C; da Rosa Araujo, AS; Fraga, S; Henriques, A; Hickmann, A; Koetz, M; Lacerda, D; Ortiz, V; Salvador, I; Türck, P | 1 |
| Fan, ZR; Li, L; Li, XZ; Liu, LQ; Ma, KT; Si, JQ; Wang, L; Zhang, LΖ | 1 |
| Hu, XH; Wang, LM; Yu, RH | 1 |
| Han, F; Liu, W; Luo, F; Shu, J | 1 |
| An, N; Feng, W; Feng, Z; Guan, H; Hu, T; Hu, Y; Liu, J; Mao, Y; Mou, J; Zhang, D | 1 |
| Black, SM; Chen, J; Chen, X; Chen, Y; Desai, AA; Duan, X; Garcia, JGN; He, W; Hong, C; Hou, C; Kuang, M; Li, M; Liao, J; Liu, C; Liu, S; Lu, W; Makino, A; Rischard, F; Tang, H; Vanderpool, RR; Wang, J; Wu, X; Yang, K; Yuan, JX; Zhang, J; Zhang, N; Zhang, Z; Zheng, Q; Zhong, N; Zou, G | 1 |
| Wang, Y; Wu, Q; Zhang, M; Zhong, B; Zhu, T | 1 |
| Chen, W; Lei, C; Ouyang, S; Zeng, G | 1 |
| Chen, H; Gao, X; He, K; Li, C; Li, H; Li, X; Liu, C; Wei, Q; Zhang, Z | 1 |
| Chen, X; Dong, F; Guo, Z; Peng, Y; Zhang, J; Zhang, S; Zhu, L | 1 |
| Ba, HX; Cao, YY; Li, XH; Li, Y; Luo, ZQ; Tang, SY | 1 |
| Eccles, CA; James, J; Kurdyukov, S; Niihori, M; Rafikov, R; Rafikova, O; Varghese, MV | 1 |
| Bialesova, L; Bouchard, A; Kinsella, BT; Mulvaney, EP; Reid, HM; Salvail, D | 1 |
| Huang, W; Kong, H; Liu, P; Peng, LY; Xie, WP; Yang, MX; Yu, M; Zhou, H | 1 |
| Bai, L; Chen, S; Chou, CH; Cui, X; Fan, F; Gongol, B; Gu, M; He, M; He, Y; Huang, HD; Jing, ZC; Lei, Y; Li, Z; Malhotra, A; Miao, Y; Rabinovitch, M; Shen, Y; Shyy, JY; Wang, X; Yan, X; Zhang, J; Zhang, Y | 1 |
| Gao, L; Li, SD; Liu, Y; Yang, MH; Zhang, Y | 1 |
| Chen, J; Chen, W; Dong, Q; Feng, P; Huang, W; Li, A; Li, H; Tang, M; Wang, R; Zhao, Y | 1 |
| Dianat, M; Mard, SA; Radan, M; Saryazdi, SSN; Sohrabi, F | 1 |
| Guo, Y; He, Y; Liu, X; Ouyang, F; Qiu, H; Zhang, Y | 1 |
| Beik, A; Iranpour, M; Jafarinejad Farsangi, S; Joukar, S; Kordestani, Z; Najafipour, H; Rajabi, S | 1 |
| Antigny, F; Cohen-Kaminsky, S; Courboulin, A; Ghigna, MR; Hautefort, A; Humbert, M; Lambert, M; Le Ribeuz, H; Montani, D; Perros, F | 1 |
| Cheng, Y; Huang, C; Li, H; Li, J; Luo, J; Rao, P; Wang, L; Wang, X | 1 |
| Chen, SS; Feng, YY; Ma, Y; Wang, HL | 1 |
| Cheng, TT; Chiu, MH; Fang, SY; Hsu, CH; Huang, CC; Lam, CF; Lin, MW; Roan, JN | 1 |
| Al-Qazazi, R; Archer, SL; Eklund, M; Hartweck, L; Hsu, S; Neuber-Hess, M; Potus, F; Prins, KW; Prisco, SZ; Rose, L; Thenappan, T; Tian, L; Wu, D | 1 |
| Chen, S; Jiang, X; Li, L; Luo, J; Wang, J; Zhang, J; Zhou, L | 1 |
| Gui, LX; Guo, JY; He, RL; Jiao, HX; Lin, MJ; Liu, XR; Wang, RX; Wu, ZJ; Zhang, RT | 1 |
| Alda, MA; Balancin, M; Batah, SS; Capelozzi, VL; Cruvinel, HR; Fabro, AT; Machado-Rugolo, J; Perdoná Rodrigues da Silva, L; Rodrigues Lopes Roslindo Figueira, R; Silva, PL; Teodoro, WR; Velosa, AP | 1 |
| Aparicio Cordero, EA; Araujo, AS; Bahr, AC; Baldo, G; Belló-Klein, A; Campos-Carraro, C; Constantin, RL; Donatti, L; Gonzalez, E; Luz de Castro, A; Ortiz, VD; Teixeira, RB; Visioli, F; Zimmer, A | 1 |
| Hu, J; Liu, S; Liu, W; Lu, S; Wang, Y; Wang, Z; Zeng, X | 1 |
| Huang, B; Li, L; Li, S; Luo, Y; Tang, C; Xu, S | 1 |
| Akagi, S; Amioka, N; Ejiri, K; Fukami, K; Higashimoto, Y; Ito, H; Kondo, M; Matsubara, H; Miyoshi, T; Nakamura, K; Nakayama, R; Sakaguchi, M; Suastika, LOS; Takaya, Y; Yoshida, M | 1 |
| Ge, L; Jiang, W; Li, K; Luan, Y; Qi, T; Sun, C; Wang, J; Xin, Q; Zhang, S | 1 |
| Akagi, S; Berrebeh, N; Boucly, A; Chaouat, A; Cottin, V; Cumont, A; Fadel, E; Guignabert, C; Huertas, A; Humbert, M; Jaïs, X; Jutant, EM; Le Vely, B; Mercier, O; Montani, D; Phan, C; Savale, L; Sitbon, O; Tamura, Y; Thuillet, R; Tromeur, C; Tu, L | 1 |
| Higuchi, T; Inagaki, T; Masaki, T; Nakaoka, Y; Pearson, JT; Saito, S; Schwenke, DO; Shirai, M; Tsuchimochi, H; Umetani, K | 1 |
| Cui, X; Dai, C; Feng, H; Guo, X; Jiang, F; Lu, W; Wang, J; Xu, X; Yin, Q; Zhang, J | 1 |
| Banerjee, S; Clark, VR; Fishbein, G; Hong, J; Park, JF; Razee, A; Saddic, L; Umar, S; Williams, T | 1 |
| Borges, RS; Duarte, GP; Gonzaga-Costa, K; Lahlou, S; Magalhães, PJC; Rebouça, CDSM; Rodrigues-Silva, MJ; Vasconcelos-Silva, AA | 1 |
| Cao, Y; Chen, F; Chu, C; Ding, J; Fulton, D; Hu, L; Huang, H; Li, K; Li, Y; Xu, P; Yu, Y | 1 |
| Fan, Y; Gao, D; Hao, Y; Li, G; Zhang, Z | 1 |
| Dignam, JP; Hobbs, AJ; Kemp-Harper, BK; Scott, TE | 1 |
| Changcheng, L; Chen, W; Gaofeng, Z; Guoping, T; Luo, J; Min, Y; Minyan, Z; Ouyang, S; Yang, L | 1 |
| Abe, K; Hirano, K; Hirano, M; Hosokawa, K; Imakiire, S; Ishikawa, T; Takana-Ishikawa, M; Tsutsui, H; Watanabe, T; Yoshida, K | 1 |
| Li, XT; Li, YL; Li, YQ; Lin, XY; Ren, XQ; Yang, DL; Zeng, FQ | 1 |
| Awada, C; Bonnet, S; Boucherat, O; Bourgeois, A; Breuils-Bonnet, S; Grobs, Y; Lemay, SE; Nadeau, V; Orcholski, M; Paulin, R; Provencher, S; Romanet, C; Shimauchi, K; Toro, V; Tremblay, E | 1 |
| Hatano, E; Iwaisako, K; Kasai, Y; Nishino, H; Okuno, M; Satoh, M; Seo, S; Taura, K; Toda, R; Yoshino, K | 1 |
| Li, X; Liu, H; Lu, X; Ma, W; Ren, F; Tan, X; Wang, S; Yu, L; Zhang, J | 1 |
| Belló-Klein, A; Bonetto, JP; Campos-Carraro, C; Carregal, VM; Cechinel, LR; Corssac, GB; Grings, M; Leipnitz, G; Massensini, AR; Parmeggiani, B; Siqueira, I; Zimmer, A | 1 |
| Gao, G; Lian, G; Lin, T; Luo, L; Wang, H; Wu, J; Xie, L | 1 |
| Askaripour, M; Beik, A; Jafari, E; Jafarinejad-Farsangi, S; Joukar, S; Najafipour, H; Rajabi, S; Safi, Z | 1 |
| Acharya, AP; Bertero, T; Chan, SY; Harvey, LD; Königshoff, M; Little, SR; Mitash, N; Pineda, R; Sun, W; Tai, YY; Tang, Y; Woodcock, CC | 1 |
| Antigny, F; Boët, A; Colsch, B; Delaporte, A; Fadel, E; Fenaille, F; Haddad, F; Hautbergue, T; Humbert, M; Junot, C; Lambert, M; Masson, B; Menager, JB; Mercier, O; Pavec, JL; Savale, L | 1 |
| Fan, J; Lv, Y; Ma, P; Wang, J; Xu, Q; Yan, L; Zhou, R | 1 |
| Fujiwara, M; Hiraku, A; Horii, C; Kawade, A; Kobayashi, S; Kondo, R; Mori, S; Ohara, N; Suzuki, Y; Suzumura, S; Tsukamoto, K; Yamamura, A; Yamamura, H | 1 |
| Dong, S; Du, H; Guo, Z; Li, P; Lu, Y; Qin, Y; Song, J; Wu, H; Zhao, X; Zhou, S; Zhu, N | 1 |
| Harper, R; Hodge, S; Maiolo, S; Reynolds, PN; Tran, HB; Zalewski, PD | 1 |
| Feng, T; Hu, Q; Li, J; Liu, B; Lu, Y; Su, Y; Sun, M; Wang, T; Xiao, R; Zhang, J; Zhu, L | 1 |
| Choi, SJ; Hong, YM; Kim, KC; Lee, H | 1 |
| Jasińska-Stroschein, M; Orszulak-Michalak, D; Oszajca, K; Ruchwa, J; Świtlik, W | 1 |
| Arase, H; Irahara, M; Kinoshita, H; Kitagawa, T; Kitaichi, T; Kurobe, H; Maeda, K; Nakayama, S; Sugano, M; Sugasawa, N; Yoshida, H | 1 |
| He, J; Li, T; Li, X; Liu, Y; Luo, H; Qi, Q; Yu, Z; Zhao, L | 1 |
| Dai, M; Gao, S; Hu, QH; Hua, CY; Li, PP; Meng, HY; Yang, ZX; Yin, YL; Yuan, LB | 1 |
| Bai, Y; Li, ZX; Lian, GC; Wang, HL; Wang, Y | 1 |
| Li, Y; Qian, Z; Wang, Y; Yang, D; Zhu, L | 1 |
| Kakuda, C; Kameshima, S; Kodama, T; Okada, M; Okamura, Y; Sakamoto, Y; Yamawaki, H | 1 |
| Bergmeister, H; Bonderman, D; Eilenberg, M; Kiss, A; Mascherbauer, J; Podesser, B; Schreiber, C | 1 |
| Fan, Y; Gao, L; Hao, Y; Jing, Z; Liu, D; Yuan, P; Zhang, Z | 1 |
| Fushida, S; Harada, SI; Hayashi, H; Hirata, M; Iseki, S; Makino, I; Miyashita, T; Miyata, T; Nakanuma, SI; Ninomiya, I; Ohta, T; Oyama, K; Tajima, H; Takamura, H; Wakayama, T | 1 |
| Chen, Y; Fu, G; Jiang, D; Xu, S; Zhu, Y | 1 |
| Li, Q; Wang, J; Wu, X; Xie, J; Xu, Y; Yu, J; Zeng, Z; Zhu, X | 1 |
| Higuchi, M; Hikasa, Y; Leong, ZP; Okida, A; Yamano, Y | 1 |
| Fu, N; Liang, Y; Shi, R; Wang, C; Wang, X; Wang, Y; Wei, Z; Xing, J; Yin, S; Zhu, D | 1 |
| Li, G; Liu, Y; Yan, D; Zhang, H; Zhang, Y; Zhao, L | 1 |
| Bijnens, B; Friedberg, MK; Gomez, O; Honjo, O; Ishii, R; Okumura, K; Sun, M | 1 |
| Gu, Q; Hao, Y; Liu, N; Qu, C; Xu, Y; Yan, Y; Yang, X | 1 |
| Fang, SY; Hsu, CH; Huang, CC; Lam, CF; Luo, CY; Roan, JN; Tsai, HW | 1 |
| Fujita, J; Ishida, A; Ohya, Y; Yamazato, M; Yamazato, Y | 1 |
| Mei, Y; Tian, W; Wang, S; Wang, Y; Xiu, C; Yan, M | 1 |
| Chen, J; Gou, D; Li, L; Li, Y; Lin, B; Luo, Y; Qian, Z; Qu, J; Raj, JU | 1 |
| Belló-Klein, A; Carraro, CC; Colombo, R; da Rosa Araujo, AS; de Lima-Seolin, BG; Lacerda, DS; Poletto Bonetto, JH; Schenkel, PC; Teixeira, RB; Türck, P | 1 |
| Deighton, J; Dunmore, BJ; Ferrer, E; Hassan, D; Long, L; Moore, S; Morrell, NW; Ormiston, ML; Stewart, DJ; Yang, XD | 1 |
| Belló-Klein, A; Bonetto, JHP; Colombo, R; de Lima-Seolin, BG; Fernandes, RO; Godoy, AEG; Hennemann, MM; Khaper, N; Litvin, IE; Sander da Rosa Araujo, A; Schenkel, PC; Teixeira, RB | 1 |
| Aquino, V; Katovich, MJ; Khoshbouei, H; Kim, S; Kumar, A; Lebowitz, JJ; Lobaton, G; Oliveira, AC; Raizada, MK; Rathinasabapathy, A; Richards, EM; Rigatto, K; Sharma, RK; Shenoy, V; Zubcevic, J | 1 |
| Alencar, AKN; Costa, DG; Cunha, VDMN; Fraga, AGM; Fraga, CAM; Groban, L; Martinez, ST; Mendes, LVP; Montagnoli, TL; Montes, GC; Silva, AMS; Sudo, RT; Trachez, MM; Wang, H; Zapata-Sudo, G | 1 |
| Tan, HR; Yang, JM; Yu, JQ; Zhang, M; Zhou, R | 1 |
| Bueno-Beti, C; Hadri, L; Hajjar, RJ; Sassi, Y | 1 |
| Chai, L; Feng, W; Li, C; Li, M; Li, S; Liu, P; Shi, W; Wang, J; Wang, Q; Yan, X; Zhai, C; Zhang, Q; Zhu, Y | 1 |
| Oda, S; Takeuchi, M; Tsuneyama, K; Yokoi, T | 1 |
| Ding, JX; Liu, Q; Qin, X; Song, FM; Su, YJ; Wei, CM; Xu, J; Zhao, JM; Zhou, B; Zong, SH | 1 |
| Hikasa, Y; Leong, ZP | 1 |
| Duan, L; Hu, GH; Jiang, M; Li, YJ; Zhang, CL | 1 |
| Cheng, Y; He, M; Kong, H; Wang, H; Xie, W; Xu, J; Yu, M | 1 |
| Du, A; Gong, J; Huang, B; Lian, G; Wang, H; Xiao, G; Xie, L; Xu, C; Zhuang, W | 1 |
| Cao, Y; Dai, S; Gao, X; Guo, Q; Li, L; Peng, YG; Wang, E; Wang, L; Yang, Y; Zhang, J; Zhang, Y | 1 |
| Gui, LX; He, RL; Lin, MJ; Liu, XR; Wang, RX; Wu, ZJ | 1 |
| Belló-Klein, A; Campos-Carraro, C; Corssac, GB; da Rosa Araujo, AS; de Lima-Seolin, BG; Dos Santos Lacerda, D; Hickmann, A; Llesuy, S; Tavares, AMV; Teixeira, RB; Turck, P | 1 |
| Asaeda, M; Eto, K; Fujita, N; Imagita, H; Kuwahara, W; Yamasaki, N | 1 |
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| Ellinghaus, P; Janssen, W; Kast, R; Klein, M; Kramer, F; Lustig, K; Milting, H; Schäfer, S | 1 |
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| Wang, HL; Zhai, FG; Zhang, XH | 1 |
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| Bradford, CN; Ferreira, AJ; Francis, J; Hong, KH; Katovich, MJ; Oh, SP; Raizada, MK; Shenoy, V; Sriramula, S; Yamazato, M; Yamazato, Y; Yuan, L | 1 |
| Ji, YQ; Li, G; Liu, CP; Lu, WX; Zhang, WH; Zhang, YJ | 1 |
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| Asai, K; Ishikawa, M; Mizuno, K; Sato, N; Takano, T | 1 |
| Liu, B; Liu, HM; Wang, XM; Wang, XQ; Yu, L; Zhou, TF | 1 |
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| Jiang, W; Jiang, Z; Li, B; Li, Y; Wang, C; Zeng, Z | 1 |
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| Baker, AH; Caruso, P; Dempsie, Y; Denby, L; Greig, JA; Khanin, R; Long, L; MacDonald, RA; MacLean, MR; Masson, R; McClure, J; Morrell, NW; Robertson, KE; Soon, E; Southgate, M | 1 |
| de Man, FS; Handoko, ML; Mouchaers, KT; van der Laarse, WJ; Vonk-Noordegraaf, A; Wong, YY | 1 |
| Alastalo, TP; Angeli, FS; Boyle, AJ; Chatterjee, K; De Marco, T; Jahn, S; Koskenvuo, JW; Mirsky, R; Schiller, NB; Yeghiazarians, Y; Zhang, Y | 1 |
| Burg, ED; Huang, X; Kuang, T; Pang, B; Wang, C; Wang, J; Yuan, JX | 1 |
| Cho, YK; Choi, WY; Eom, GH; Kee, HJ; Kim, HS; Kook, H; Ma, JS; Nam, KI | 1 |
| Atsma, DE; Schalij, MJ; Steendijk, P; Umar, S; van der Laarse, A; van der Wall, EE; Ypey, DL | 1 |
| Badejo, AM; Casey, DB; Dhaliwal, JS; Fokin, A; Golwala, NH; Greco, AJ; Hyman, AL; Kadowitz, PJ; Murthy, SN; Nossaman, BD; Sikora, JL | 1 |
| Campian, ME; de Bakker, JM; de Bruin, K; Hardziyenka, M; Tan, HL; van Eck-Smit, BL; Verberne, HJ | 1 |
| Al-Lamki, RS; Grimminger, F; Lever, AM; Li, X; Morrell, NW; Schermuly, RT; Southwood, M; Yang, J; Zhao, J | 1 |
| Bernardes, J; Brandão-Nogueira, A; Gonçalves, H; Henriques-Coelho, T; Leite-Moreira, A; Rocha, AP | 1 |
| Etlinger, JD; Farahani, R; Huang, J; Mathew, R; Murakami, K; Olson, SC; Peng, H | 1 |
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| Chen, JZ; Du, CQ; Hu, H; Hu, XS; Li, N; Wang, K; Yao, L; Zeng, CL; Zhang, FR | 1 |
| Beliën, JA; Grunberg, K; Hadi, AM; Meijer, GA; Mouchaers, KT; Schalij, I; van der Laarse, WJ; Vonk-Noordegraaf, A | 1 |
| D'Armiento, J; George, J | 1 |
| Chen, CF; Chen, JS; Hsu, HH; Hsu, JY; Ko, WJ; Lai, IR; Lee, YC; Ruan, T | 1 |
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| Han, DD; Li, XQ; Wang, HL; Wang, HM; Yang, CG; Zhang, XH | 1 |
| Abdel-Bakky, MS; Ashfaq, MK; Hammad, MA; Walker, LA | 1 |
| Amin, KA; Awad, el-ST; Hashem, KS; Hassan, MS | 1 |
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| Chen, HM; Duan, YY; Liang, NN; Sun, DD; Wang, YM; Yuan, LJ | 1 |
| Billaud, M; Dahan, D; Guibert, C; Marthan, R; Savineau, JP | 1 |
| Endoh, H; Fukuda, K; Hirose, M; Miura, M; Nakano, M; Shimokawa, H; Shindoh, C; Shirato, K; Sugai, Y; Wakayama, Y | 1 |
| Cornitescu, T; Dahal, BK; Ghofrani, HA; Grimminger, F; Hoffmann, J; Kaulen, C; Kosanovic, D; Kuebler, WM; Reiss, I; Savai, R; Schermuly, RT; Seeger, W; Weissmann, N | 1 |
| Beretta, L; Fumagalli, F; Latini, R; Masson, S; Santaniello, A; Scorza, R; Zambelli, V | 1 |
| Brandes, RP; Cornitescu, T; Dahal, BK; Davie, N; Ghofrani, HA; Grimminger, F; Janssen, W; Kojonazarov, B; Kosanovic, D; Luitel, H; Schermuly, RT; Seeger, W; Sydykov, A; Weissmann, N | 1 |
| D'Armiento, J; George, J; Sun, J | 1 |
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| Bisserier, M; Bonnet, S; Courboulin, A; Jacob, MH; Meloche, J; Paulin, R | 1 |
| Bartelds, B; Berger, RMF; Boersma, B; Dickinson, MG; Mohaupt, S; Takens, J; van Albada, M; van Loon, RLE; Wijnberg, H | 1 |
| Alhussaini, AA; Bogaard, HJ; Farkas, D; Farkas, L; Gomez-Arroyo, JG; Kraskauskas, D; Voelkel, NF | 1 |
| Angeli, FS; Boyle, AJ; De Marco, T; Helenius, H; Koskenvuo, JW; Mirsky, R; Yeghiazarians, Y; Zhang, Y | 1 |
| Dahan, D; Guibert, C; Komohara, Y; Marthan, R; Masuda, H; Morimatsu, Y; Ohnishi, K; Sakashita, N; Takeya, M | 1 |
| Bogaards, SJ; de Man, FS; Handoko, ML; Paulus, WJ; Postmus, PE; Schalij, I; van Ballegoij, JJ; van der Velden, J; Vonk-Noordegraaf, A; Westerhof, N | 1 |
| Anderson, ME; Chen, B; Grumbach, IM; Guo, A; Li, Y; Sanders, P; Song, LS; Wang, LC; Weiss, RM; Xie, YP; Zimmerman, K | 1 |
| Bauer, EM; Bauer, PM; Calzada, MJ; Champion, HC; Feijoo-Cuaresma, M; Isenberg, JS; Pilewski, JM; Rogers, NM; Yao, M; Zuckerbraun, BS | 1 |
| Lu, Y; Luan, Y; Wang, YB; Wei, DE; Zhang, ZH | 1 |
| Clozel, M; Hess, P; Rey, M | 1 |
| Campen, MJ; Channell, MM; Lucas, SN; Naik, JS; Paffett, ML | 1 |
| Araujo, AS; Belló-Klein, A; Caron-Lienert, R; Colombo, R; Mosele, F; Ribeiro, MF; Tavares, AM | 1 |
| Han, DD; Liu, JR; Wang, HL; Wang, Y; Zhang, XH | 1 |
| Dahal, BK; Ghofrani, HA; Kojonazarov, B; Kwapiszewska, G; Markart, P; Marsh, LM; Meinhardt, A; Olschewski, A; Preissner, KT; Schermuly, RT; Seeger, W; Steinhoff, M; Taube, C; Weissmann, N; Wygrecka, M | 1 |
| Ahmad, F; Champion, HC; Kahloon, R; Kass, DJ; Loh, K; Markowski, M; Rajkumar, R; Rattigan, E; Saqi, A; Savir, A; Yu, L | 1 |
| Archer, SL; Chen, Y; Fang, YH; Hong, Z; Marsboom, G; Morrow, E; Piao, L; Pogoriler, J; Rehman, J; Ryan, JJ; Thenappan, T; Toth, PT; Weir, EK; Wu, X; Zhang, HJ | 1 |
| Berghausen, EM; Brandes, RP; Butrous, E; Butrous, G; Dabral, S; Dahal, BK; Ghofrani, HA; Grimminger, F; Pullamsetti, SS; Rosenkranz, S; Savai, R; Schermuly, RT; Seeger, W; Tretyn, A; Weissmann, N | 1 |
| Kobuchi, S; Maehara, R; Matsumura, Y; Ohkita, M; Suzuki, R; Tanaka, R | 1 |
| Aizawa, Y; Asami, F; Hanawa, H; Higuchi, M; Ikarashi, N; Kato, K; Kobayashi, H; Nakazawa, M; Nomoto, M; Oda, M; Ozawa, T; Saito, H; Suzuki, T; Takayama, T; Toba, K; Yanagawa, T | 1 |
| Guan, RJ; Li, JJ; Li, XL | 1 |
| Aziz, A; Kanter, EM; Lee, AM; Moon, CJ; Moon, MR; Okada, S; Yamada, KA | 1 |
| Barreiro, EJ; da Silva, JS; Lima, LM; Nunes, IK; Pontes, LB; Sudo, RT; Zapata-Sudo, G | 1 |
| Dong, H; Fernandez, RA; Guo, Q; Makino, A; Pohl, NM; Smith, KA; Yamamura, A; Yamamura, H; Yuan, JX; Zeifman, A; Zimnicka, AM | 1 |
| Hatano, E; Iwaisako, K; Koyama, Y; Miyagawa-Hayashino, A; Nagata, H; Nakamura, K; Narita, M; Taura, K; Uemoto, S | 1 |
| Chaumais, MC; De Man, FS; Dorfmüller, P; Eddahibi, S; Fadel, E; François, C; Girerd, B; Guignabert, C; Huertas, A; Humbert, M; Lecerf, F; Montani, D; Perros, F; Tu, L | 1 |
| Anderson, T; Campen, MJ; Candelaria, G; Hesterman, J; Hoppin, J; Irwin, D; Lucas, S; Norenberg, J; Paffett, ML | 1 |
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| Cui, WY; Li, JS; Lng, CL; Wang, H | 1 |
| Gewitz, MH; Huang, J; Mathew, R; Wolk, JH | 1 |
| Atli, O; Demirel-Yilmaz, E; Ilgin, S; Sirmagul, B; Usanmaz, SE | 1 |
| Ji, YQ; Liu, CP; Lu, WX; Zeng, Q; Zhang, WH; Zhang, YJ | 1 |
| Best, J; Chwalek, K; Egemnazarov, B; Eickelberg, O; Fink, L; Kwapiszewska, G; Marsh, LM; Olschewski, A; Osswald, SL; Schermuly, RT; Seeger, W; Weisel, FC; Weissmann, N; Wilhelm, J; Wygrecka, M | 1 |
| Furuichi, K; Iwata, Y; Kaneko, S; Sakai, Y; Shimizu, M; Wada, T; Yokoyama, H | 1 |
| Al-Lamki, RS; Berk, J; Li, X; Morrell, NW; Schermuly, RT; Weiss, A; Wu, C; Yang, J | 1 |
| Bai, Y; Liu, M; Sun, YX; Wang, HL; Wang, HM; Wang, Y; Zhang, XH | 1 |
| Blumberg, F; Pfeifer, M; Popara, V; Schroll, S; Sebah, D; Wagner, M | 1 |
| Angelini, A; Calvani, M; Dalla Libera, L; Della Barbera, M; Dona, M; Gobbo, V; Mosconi, L; Peluso, G; Ravara, B; Sandri, M; Vescovo, G | 1 |
| Des Tombe, AL; Lee-De Groot, MB; Van Beek-Harmsen, BJ; Van Der Laarse, WJ | 1 |
| Goto, J; Ishikawa, K; Kawamura, K; Maruyama, Y; Matumoto, H; Sugawara, D; Watanabe, Y | 1 |
| Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG; Qiu, D; Vaszar, LT | 1 |
| Beilfuss, A; Brandt, K; Brodde, OE; Heinroth-Hoffmann, I; Leineweber, K; Pönicke, K; Wludyka, B | 1 |
| Bethea, NW; DeLeve, LD; Ito, Y; McCuskey, MK; McCuskey, RS; Wang, X | 1 |
| Bernocchi, P; Boraso, A; Cargnoni, A; Ceconi, C; Dalla Libera, L; Ferrari, R; Parrinello, G; Vescovo, G | 1 |
| Cernacek, P; Dupuis, J; Jasmin, JF | 1 |
| Asahara, T; Chiba, Y; Fukuyama, N; Hara, H; Harada-Shiba, M; Hino, J; Horio, T; Kanda, M; Kangawa, K; Miyatake, K; Mochizuki, N; Mori, H; Nagaya, N; Nishioka, K; Okumura, H; Tabata, Y; Uematsu, M | 1 |
| Brodde, OE; Hartmann, O; Hasenfuss, G; Kögler, H; Leineweber, K; Nguyen van, P; Schott, P | 1 |
| Butrous, G; Ermert, L; Ermert, M; Ghofrani, HA; Grimminger, F; Guenther, A; Kreisselmeier, KP; Rose, F; Schermuly, RT; Seeger, W; Walmrath, D; Weissmann, N; Yilmaz, H | 1 |
| Hashimoto, K; Iwase, M; Kanazawa, H; Kato, Y; Kawata, N; Koike, Y; Nishimura, M; Nishizawa, T; Noda, A; Takagi, K; Yokoi, T; Yokota, M; Yoshimori, Y | 1 |
| Bongrani, S; Cargnioni, A; Ferrari, R; Gitti, GL; Pasini, E; Pastore, F; Razzetti, R | 1 |
| D'iakonov, KB; Davydova, MP; Liubitskiĭ, OB; Medvedeva, HA; Postnikov, AB | 1 |
| Costa, DL; Doerfler, DL; Everitt, JI; Gardner, SY; Kodavanti, UP; Ledbetter, A; McGee, JK; Winsett, DW | 1 |
| Farahmand, F; Hill, MF; Singal, PK | 1 |
| Gewitz, M; Huang, J; Mathew, R; Patel, K; Sehgal, PB; Shah, M | 1 |
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| Chachques, JC; Monnet, E | 1 |
| Aigner, C; Fink, L; Ghofrani, HA; Grimminger, F; Haredza, P; Kiss, L; Klepetko, W; Muyal, JP; Pullamsetti, S; Schermuly, RT; Seeger, W; Voswinckel, R; Weissmann, N | 1 |
| Bonartsev, AP; D'iakonov, KB; Medvedeva, NA; Postnikov, AB; Slavutskaia, AV | 1 |
| Fujimori, A; Goto, K; Iemitsu, M; Miyauchi, T; Sakai, S; Sanagi, M; Shikama, H; Sudoh, K; Yamaguchi, I; Yuyama, H | 1 |
| Dumitrascu, R; Gessler, T; Ghofrani, HA; Grimminger, F; Pullamsetti, S; Schermuly, RT; Schulz, A; Seeger, W; Weissmann, N; Woyda, K; Yilmaz, H | 1 |
| Colvin, K; Gebb, S; Imamura, M; Ivy, DD; Jones, PL; Lee, DS; McMurtry, IF; Oka, M | 1 |
| Berger, RM; Cromme-Dijkhuis, AH; Kemna, MS; Schoemaker, RG; van Albada, ME; van Veghel, R | 1 |
| Bongalon, S; Dai, YP; Mutafova-Yambolieva, VN; Parks, SD; Tian, H; Yamboliev, IA | 1 |
| Endo, H; Hirose, M; Kagaya, Y; Miura, M; Nakano, M; Shimokawa, H; Shirato, K; Sugai, Y; Takahashi, J; Wakayama, Y; Watanabe, J | 1 |
| Binkert, C; Clozel, M; Hess, P; Iglarz, M; Qiu, C; Rey, M | 1 |
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| Campian, ME; Hardziyenka, M; Michel, MC; Tan, HL | 1 |
| Dupuis, J; Jasmin, JF; Lisanti, MP; Mercier, I; Tanowitz, HB | 1 |
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| Baber, SR; Bunnell, BA; Deng, W; Hyman, AL; Kadowitz, PJ; Master, RG; Murthy, SN; Taylor, BK | 1 |
| Campian, ME; de Bruin-Bon, HA; Hardziyenka, M; Michel, MC; Tan, HL | 1 |
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| Hirata, Y; Morita, T; Nagai, R; Nakamura, K; Sahara, M; Sata, M | 1 |
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| Dumitrascu, R; Eickelberg, O; Hecker, M; Knaus, P; Kouri, FM; Kwapiszewska, G; Morty, RE; Nejman, B; Peters, DM; Schermuly, RT; Seeger, W; Zakrzewicz, A | 1 |
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| Baybutt, RC; Halder, A; Herndon, BL; Kamal, R; Mein, J; Molteni, A; Reppert, S; Umbehr, J; Van Dillen, C; Xue, Y | 1 |
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| Blaxall, BC; Cool, CD; Galaria, II; Hall, CM; Harvey, JL; Kallop, DY; Meoli, DF; Miller, CM; Pierce, RA; Swarthout, RF; Taubman, MB; White, RJ | 1 |
| Christians, U; Jonscher, K; Kaisers, U; Laudi, S; Schniedewind, B; Schöning, W; Steudel, W; Trump, S | 1 |
| Bauer, NR; McMurtry, IF; Moore, TM | 1 |
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| Bertipaglia, L; Calò, LA; Corradini, R; Dalla Libera, L; Davis, PA; Naso, A; Pagnin, E; Piccoli, A; Savica, V; Spinello, M | 1 |
| Adachi, T; Kamezaki, F; Koide, S; Nakata, S; Okazaki, M; Otsuji, Y; Sasaguri, Y; Tanimoto, A; Tasaki, H; Tsutsui, M; Yamashita, K | 1 |
| Aizawa, Y; Kangawa, K; Kodama, M; Mori, H; Nagaya, N; Obata, H; Ohnishi, S; Sakai, Y; Takeshita, S | 1 |
| Dony, E; Dumitrascu, R; Flockerzi, D; Ghofrani, HA; Grimminger, F; Lai, YJ; Pullamsetti, SS; Savai, R; Schermuly, RT; Schudt, C; Seeger, W; Weissmann, N | 1 |
| Laboy, M; Lasky, JA; Prockop, DJ; Spees, JL; Sullivan, DE; Whitney, MJ; Ylostalo, J | 1 |
| Chakravarty, S; Champion, HC; Gordy, K; Higgins, L; Medicherla, S; Murphy, A; Neptune, E; Podowski, M; Protter, A; Sehgal, PB; Shimoda, LA; Tuder, RM; Xu, F; Zaiman, AL; Zhen, L | 1 |
| Ikeda, M; Ito, K; Ito, KM; Kato, T; Nasu, T; Sonoda, H | 1 |
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| Bradley, BL; Kopecky, SL; Miller, WC; Rice, DL; Unger, KM | 1 |
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| Imai, S; Kanda, T; Murata, K; Suzuki, T; Takahashi, T | 1 |
| Arend, WP; Bridges, J; Tuder, RM; Voelkel, NF | 1 |
| Hosoda, Y; Kanai, Y | 1 |
| Hosoda, Y | 1 |
| Harada, Y; Inoue, M; Mori, C; Tanaka, O; Watanabe, K | 1 |
| Kikuchi, K; Mori, C; Ohie, T; Watanabe, K | 1 |
| Eguchi, S; Miyamura, H; Sugawara, M; Tatebe, S; Watanabe, H | 1 |
| Baradarian, R; Chiu, DT; Kim, ES; Smith, CR; Smith, ML; Smith, TJ; Yano, OJ | 1 |
| Bernocchi, P; Ceconi, C; Curello, S; Ferrari, R; Pasini, E; Pedersini, P | 1 |
| Inoue, M; Kanda, T; Kobayashi, I; Kodama, K; Nagai, R; Suzuki, T; Takahashi, T | 1 |
| Bittner, HB; Chen, EP; Craig, DM; Davis, RD; Van Trigt, P | 1 |
| Bittner, HB; Chen, EP; Craig, D; Davis, RD; Tull, F; Van Trigt, P | 1 |
| Nohara, H; Okada, K; Okada, M; Wakiyama, H; Yamagishi, H; Yamashita, C | 1 |
| Biswas, SS; Bittner, HB; Chen, EP; Davis, RD; Tull, F; Van Trigt, P | 1 |
| Bittner, HB; Chen, EP; Davis, RD; Van Trigt, P | 2 |
| Bernstein, M; Botney, MD; Okada, K; Patterson, GA; Tanaka, Y; Zhang, W | 1 |
| Brown, L; Dagger, A; Miller, J; Sernia, C | 1 |
| Goto, A; Hara, K; Hazama, H; Hisada, T; Igarashi, K; Kimura, K; Nagata, T; Omata, M; Uehara, Y | 1 |
| Inoue, M; Iwamoto, A; Kanda, T; Kobayashi, I; Nagai, R; Sakamaki, T; Sato, K; Sumino, H; Takahashi, T | 1 |
| Kasahara, Y; Kimura, H; Kuriyama, T; Kurosu, K; Matsushima, K; Mukaida, N; Sugito, K | 1 |
| Bernstein, ML; Botney, MD; Okada, K; Schuster, DP; Zhang, W | 1 |
| Chen, LC; Gordon, T; Nadziejko, C; Schlesinger, R | 2 |
| Kasukawa, R; Miyata, M; Sakuma, F | 1 |
| Segall, HJ; Wilson, DW; Woods, LW | 1 |
| DeLeve, LD; Epstein, RB; Hu, L; Kanel, GC; McCuskey, MK; McCuskey, RS; Wang, X | 1 |
| Campen, MJ; Costa, DL; Gardner, SY; Jackson, MC; Kodavanti, UP; Ledbetter, AD; Richards, JR; Watkinson, WP | 1 |
| Block, N; Brock, TA; Chen, SJ; Chen, YF; Dixon, RA; Munsch, CL; Sherwood, SJ; Tilton, RG; Wu, C | 1 |
| Cowan, KN; Heilbut, A; Humpl, T; Ito, S; Lam, C; Rabinovitch, M | 1 |
| Kaneda, Y; Kyotani, S; Miyatake, K; Morishita, R; Nagaya, N; Nakanishi, N; Nishikimi, T; Ogihara, T; Shimonishi, M; Tanabe, T; Uematsu, M; Yamagishi, M; Yokoyama, C | 1 |
| Bernocchi, P; Ceconi, C; de Jong, JW; de Jonge, R; Harrison, R; Keijzer, E; Schoemaker, RG; Sharma, HS | 1 |
| Benson, GV; Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG | 1 |
| Brodde, OE; Gerbershagen, HP; Giessler, C; Heinroth-Hoffmann, I; Leineweber, K; Pönicke, K; Seyfarth, T | 1 |
| Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG; Veve, I | 1 |
| Kim, CS; Lee, JU; Lee, WJ; Paek, YW; Park, HK; Park, SJ | 1 |
| Tanino, Y | 1 |
| Ambrosio, GB; Dalla Libera, L; Vescovo, G | 1 |
| Billiar, TR; Ho, C; Kanno, S; Lee, PC; Wu, YJ | 1 |
| Cho, KW; Kim, SH; Kim, SZ; Kim, YA; Lee, KS; Seul, KH | 1 |
| Campbell, AI; Sandhu, R; Stewart, DJ; Zhao, Y | 1 |
| Kaneko, N; Kato, S; Kishiro, I; Machida, M; Sugimura, H; Suzuki, H | 1 |
| Goto, Y; Honda, M; Ishikawa, S; Ishinaga, Y; Kuzuo, H; Morioka, S; Moriyama, K; Yamada, S; Yoshikane, H | 1 |
| Heath, D | 1 |
| Anderson, SL; Epstein, RB; Min, KW; Syzek, L | 1 |
| Ceconi, C; Ferrari, R; Harris, P; Heath, D; O'Neill, D; Rodella, A; Smith, P | 1 |
| Kanisawa, M; Kato, T; Kitamura, H | 1 |
| Fujita, A; Kakusaka, I; Kaneko, N; Kiyatake, K; Kuriyama, T; Nakano, K; Okada, O; Sugita, T; Suzuki, A; Watanabe, S | 1 |
| Harding, SE; Jones, SM; Poole-Wilson, PA; Vescovo, G | 1 |
| Cottrill, CM; Gillespie, MN; Johnson, GL | 1 |
| Deeg, HJ; Luk, K; Shulman, HM; Shuman, WB; Storb, R | 1 |
| Bruner, LH; Bull, RW; Roth, RA | 1 |
| Kuriyama, T; Sawada, A; Sugita, T; Watanabe, S | 1 |
| Kakusaka, I; Kohchi, F; Kuriyama, T; Naitoh, T; Ogata, T; Okada, O; Sawada, A; Sugita, T; Watanabe, S; Yamagishi, F | 1 |
12 review(s) available for monocrotaline and Disease Models, Animal
| Article | Year |
|---|---|
A review of genetically-driven rodent models of pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Artery; Rodentia | 2022 |
Animal models of pulmonary hypertension: Getting to the heart of the problem.
Topics: Animals; Disease Models, Animal; Heart Failure; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Ventricular Dysfunction, Right; Ventricular Function, Right | 2022 |
Mesenchymal stem/stromal cell therapy for pulmonary arterial hypertension: Comprehensive review of preclinical studies.
Topics: Animals; Disease Models, Animal; Hemodynamics; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Arterial Hypertension; Vascular Remodeling | 2019 |
Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Mice; Monocrotaline; Rats | 2015 |
Novel approaches to treat experimental pulmonary arterial hypertension: a review.
Topics: Animals; Antihypertensive Agents; Cell- and Tissue-Based Therapy; Disease Models, Animal; Genetic Therapy; Hypertension, Pulmonary; Monocrotaline | 2010 |
The monocrotaline model of pulmonary hypertension in perspective.
Topics: Acute Lung Injury; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Humans; Hypertension, Pulmonary; Lung; Monocrotaline; Myocarditis | 2012 |
Nodular lesions and mesangiolysis in diabetic nephropathy.
Topics: Animals; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Endothelial Cells; Extracellular Matrix; Glomerular Mesangium; Humans; Kidney; Monocrotaline; Renal Insufficiency, Chronic | 2013 |
Animal models of heart failure: what is new?
Topics: Animals; Blood Pressure; Cardiac Volume; Cardiomyopathy, Dilated; Disease Models, Animal; Doxorubicin; Heart Failure; Humans; Imipramine; Ligation; Monocrotaline; Myocardial Ischemia | 2005 |
How valid are animal models to evaluate treatments for pulmonary hypertension?
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Ductus Arteriosus; Embolism; Humans; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Poisons | 2006 |
[Animal models of pulmonary arterial hypertension].
Topics: Animals; Animals, Genetically Modified; Arteriovenous Shunt, Surgical; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline | 2007 |
[Monocrotaline-induced pulmonary hypertension in animals].
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline; Rats; Rats, Sprague-Dawley | 2001 |
Apoptosis and changes in contractile protein pattern in the skeletal muscle in heart failure.
Topics: Angiotensin Receptor Antagonists; Animals; Apoptosis; Biphenyl Compounds; Contractile Proteins; Disease Models, Animal; Heart Failure; Humans; Irbesartan; Monocrotaline; Muscle, Skeletal; Muscular Atrophy; Myosin Heavy Chains; Rats; Sphingosine; Tetrazoles; Tumor Necrosis Factor-alpha | 2001 |
2 trial(s) available for monocrotaline and Disease Models, Animal
| Article | Year |
|---|---|
Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium handling.
Topics: Animals; Arrhythmias, Cardiac; Benzhydryl Compounds; Calcium; Connexin 43; Disease Models, Animal; Fura-2; Glucose; Glucosides; Heart Failure; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Sodium; Ventricular Dysfunction, Right; Ventricular Remodeling | 2022 |
Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.
Topics: Adult; Aged; Animals; Benzamides; Cell Division; Dichloroacetic Acid; Disease Models, Animal; Drug Monitoring; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Gene Expression Profiling; Glycolysis; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Indoles; Lung; Male; Middle Aged; Monocrotaline; Piperazines; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sunitinib; Young Adult | 2013 |
526 other study(ies) available for monocrotaline and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Characterization of a New Monocrotaline Rat Model to Study Chronic Neonatal Pulmonary Hypertension.
Topics: Animals; Animals, Newborn; Chronic Disease; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Rats | 2021 |
Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Hemoglobins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Inositol Phosphates; Male; Monocrotaline; Myocardial Contraction; Rats; Rats, Wistar; Treatment Outcome; Ventricular Dysfunction, Right; Ventricular Function, Right | 2021 |
Right-sided heart failure is also associated with transverse tubule remodeling in the left ventricle.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Heart Failure; Heart Ventricles; Hypertrophy, Left Ventricular; Hypertrophy, Right Ventricular; Male; Membrane Proteins; Monocrotaline; Rats, Wistar; Ryanodine Receptor Calcium Release Channel; Sarcomeres; Ventricular Function, Left; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension.
Topics: Animals; Cation Transport Proteins; Cell Movement; Cell Proliferation; CREB-Binding Protein; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Smooth Muscle; Protein Phosphatase 2; Pulmonary Artery; Rats; Transcriptional Activation; Tumor Hypoxia; Zinc | 2021 |
Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension.
Topics: Animals; Apoptosis; Arterial Pressure; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor CHOP; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right; X-Box Binding Protein 1 | 2021 |
Intermittent Fasting Enhances Right Ventricular Function in Preclinical Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fasting; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right; Ventricular Function, Right | 2021 |
Pioglitazone restores phosphorylation of downregulated caveolin-1 in right ventricle of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Caveolin 1; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Phosphorylation; Pioglitazone; Rats; Rats, Wistar | 2022 |
Congestive Hepatopathy Secondary to Right Ventricular Hypertrophy Related to Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Hypertrophy, Right Ventricular; Liver Diseases; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2021 |
Effects of Crocin on CCL2/CCR2 Inflammatory Pathway in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats.
Topics: Animals; Carotenoids; Chemokine CCL2; Disease Models, Animal; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Receptors, CCR2; Vascular Remodeling | 2022 |
The therapeutic effect and mechanism of Rapamycin combined with HO-3867 on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline; Piperidones; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sirolimus | 2022 |
The mouse model of hepatic veno-occlusive disease.
Topics: Animals; Cytokines; Disease Models, Animal; Hepatic Veno-Occlusive Disease; Inflammation Mediators; Liver; Liver Cirrhosis; Male; Mice, Inbred BALB C; Monocrotaline; Necrosis; Platelet Activation; Time Factors | 2021 |
Protective effects of Dapagliflozin on the vulnerability of ventricular arrhythmia in rats with pulmonary artery hypertension induced by monocrotaline.
Topics: Animals; Arrhythmias, Cardiac; Benzhydryl Compounds; Disease Models, Animal; Glucosides; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2022 |
Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Disease Models, Animal; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Pulmonary Artery; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, G-Protein-Coupled; Receptors, Neurotransmitter; Systole; Vasoconstriction; Ventricular Dysfunction, Right; Ventricular Function, Right | 2022 |
DL0805-1, a novel Rho-kinase inhibitor, attenuates lung injury and vasculopathy in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bosentan; Disease Models, Animal; Hypertension, Pulmonary; Indazoles; Male; Monocrotaline; Nitriles; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents | 2022 |
Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Phosphatidylinositol 3-Kinases; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Vascular Endothelial Growth Factor A; Ventricular Remodeling | 2022 |
Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.
Topics: Animals; Arrhythmias, Cardiac; Dantrolene; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Prognosis; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Ventricular Dysfunction, Right; Ventricular Function, Right | 2022 |
Puerarin-V prevents the progression of hypoxia- and monocrotaline-induced pulmonary hypertension in rodent models.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Isoflavones; Mice; Monocrotaline; Phosphatidylinositol 3-Kinases; Pulmonary Artery; Rats; Rodentia; Vascular Remodeling | 2022 |
Identifying Potential Mitochondrial Proteome Signatures Associated with the Pathogenesis of Pulmonary Arterial Hypertension in the Rat Model.
Topics: Animals; Biomarkers; Disease Models, Animal; Down-Regulation; Gene Ontology; Gene Regulatory Networks; Lung; Male; MicroRNAs; Mitochondria; Monocrotaline; Protein Interaction Maps; Proteome; Proteomics; Pulmonary Arterial Hypertension; Rats; Rats, Wistar; Signal Transduction; Transcriptome; Up-Regulation | 2022 |
Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Glucosides; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Sildenafil Citrate; Vascular Remodeling | 2022 |
Thrombopoietin accumulation in hepatocytes induces a decrease in its serum levels in a sinusoidal obstruction syndrome model.
Topics: Animals; Biomarkers; Disease Models, Animal; Female; Hepatic Veno-Occlusive Disease; Hepatocytes; Humans; Mice; Mice, Inbred ICR; Monocrotaline; Rats; Thrombopoietin | 2022 |
Mesenchymal Stem Cell-derived Nanovesicles as a Credible Agent for Therapy of Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Extracellular Vesicles; Hypertension, Pulmonary; Mesenchymal Stem Cells; MicroRNAs; Monocrotaline; Rats | 2022 |
Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Humans; Monocrotaline; Protein-Tyrosine Kinases; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2022 |
Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-κB pathways.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Glucosides; Hypertension, Pulmonary; MAP Kinase Kinase Kinases; Monocrotaline; Monoterpenes; NF-kappa B; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2022 |
The Levels of TNF-
Topics: Animals; Blood Coagulation; Disease Models, Animal; Drug Carriers; Hypertension, Pulmonary; Monocrotaline; Nanoparticles; Pulmonary Artery; Rats; Sildenafil Citrate; Thromboplastin; Tumor Necrosis Factor-alpha | 2022 |
Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Imatinib Mesylate; MicroRNAs; Monocrotaline; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2022 |
Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension.
Topics: Animals; Atrial Natriuretic Factor; Cytokine Receptor gp130; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fibrosis; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammasomes; Macrophage Activation; Macrophages; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Pulmonary Arterial Hypertension; Rats; Ventricular Dysfunction, Right | 2022 |
Artemisinin and Its Derivate Alleviate Pulmonary Hypertension and Vasoconstriction in Rodent Models.
Topics: Animals; Artemisinins; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Myocytes, Smooth Muscle; NADPH Oxidases; Nitric Oxide; Rats; Reactive Oxygen Species; Rodentia; Signal Transduction; Vascular Remodeling; Vasoconstriction | 2022 |
Srolo Bzhtang reduces inflammation and vascular remodeling via suppression of the MAPK/NF-κB signaling pathway in rats with pulmonary arterial hypertension.
Topics: Animals; Cytokines; Disease Models, Animal; Hypoxia; Inflammation; Mitogen-Activated Protein Kinases; Monocrotaline; NF-kappa B; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2022 |
Astragaloside IV in Hypoxic Pulmonary Hypertension: an In Vivo and In Vitro Experiments.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Rats; Saponins; Tumor Necrosis Factor-alpha | 2022 |
Silencing TUFM Inhibits Development of Monocrotaline-Induced Pulmonary Hypertension by Regulating Mitochondrial Autophagy via AMPK/mTOR Signal Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; bcl-2-Associated X Protein; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases | 2022 |
Apolipoprotein A5 ameliorates MCT induced pulmonary hypertension by inhibiting ER stress in a GRP78 dependent mechanism.
Topics: Animals; Apolipoprotein A-V; Cell Proliferation; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley | 2022 |
Mineralocorticoid Receptor Antagonism by Finerenone Attenuates Established Pulmonary Hypertension in Rats.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Mice; Mineralocorticoid Receptor Antagonists; Monocrotaline; Naphthyridines; Pulmonary Artery; Rats; Receptors, Mineralocorticoid; Vascular Remodeling | 2022 |
Intra-Airway Gene Delivery for Pulmonary Hypertension in Rodent Models.
Topics: Animals; Disease Models, Animal; Genetic Therapy; Heart Failure; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Rats; Rodentia | 2022 |
Attenuating effect of magnesium on pulmonary arterial calcification in rodent models of pulmonary hypertension.
Topics: Animals; Calcium; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Magnesium; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; RNA, Messenger; Rodentia; Transcription Factors | 2022 |
Resistance Exercise Training Mitigates Left Ventricular Dysfunctions in Pulmonary Artery Hypertension Model.
Topics: Animals; Collagen Type I; Collagen Type III; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Physical Conditioning, Animal; Pulmonary Artery; Rats; Rats, Wistar; Resistance Training; Ventricular Dysfunction, Left | 2022 |
Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Arginine Vasopressin; Cysteine; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hepatocyte Growth Factor; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Malondialdehyde; Melatonin; Monocrotaline; NF-E2-Related Factor 2; Proto-Oncogene Proteins; Pulmonary Arterial Hypertension; Rats; RNA, Small Interfering; Ventricular Remodeling | 2022 |
Activation of Autophagy Induces Monocrotaline-Induced Pulmonary Arterial Hypertension by FOXM1-Mediated FAK Phosphorylation.
Topics: Actins; Animals; Autophagy; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Forkhead Box Protein M1; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Ki-67 Antigen; Monocrotaline; Phosphorylation; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2022 |
Saluisn-β contributes to endothelial dysfunction in monocrotaline-induced pulmonary arterial hypertensive rats.
Topics: Acetylcholine; Animals; Antioxidants; Disease Models, Animal; Hypertension; Hypertension, Pulmonary; Immunoglobulin G; Monocrotaline; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Superoxides | 2022 |
Exercise training counteracts the cardiac metabolic remodelling induced by experimental pulmonary arterial hypertension.
Topics: Amino Acids; Animals; Disease Models, Animal; Fatty Acids; Glucose; Glucose Transporter Type 4; Hypertension, Pulmonary; Lactate Dehydrogenases; Male; Monocrotaline; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2022 |
[Pulmonary Vascular Remodeling Characteristics of Pulmonary Arterial Hypertension Mouse Model Induced by Left Pneumonectomy and Jugular Vein Injection of Monocrotaline Pyrrole].
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Jugular Veins; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Neointima; Pneumonectomy; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling | 2022 |
Role of Endothelin-1 in Right Atrial Arrhythmogenesis in Rabbits with Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Arrhythmias, Cardiac; Connexin 43; Disease Models, Animal; Endothelin-1; Familial Primary Pulmonary Hypertension; Monocrotaline; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rabbits | 2022 |
Cardioprotective Effect of Resistance Exercise on Left Ventricular Remodeling Associated with Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Resistance Training; Vascular Remodeling; Ventricular Remodeling | 2022 |
Cannabidiol inhibits lung proliferation in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Cannabidiol; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Lung; Monocrotaline; Procollagen; Rats; Transforming Growth Factor beta1 | 2023 |
Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3β signaling pathway and alleviates pulmonary arterial hypertension in rats.
Topics: Animals; Cell Transdifferentiation; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Glycogen Synthase Kinase 3 beta; Hypertension, Pulmonary; Male; Monocrotaline; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Signal Transduction | 2023 |
Shikonin improves pulmonary vascular remodeling in monocrotaline‑induced pulmonary arterial hypertension via regulation of PKM2.
Topics: Animals; Disease Models, Animal; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyruvate Kinase; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2023 |
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Echocardiography; Heart Ventricles; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Ventricular Dysfunction, Right; Ventricular Function, Right | 2023 |
Ranolazine exerts atrial antiarrhythmic effects in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Heart Atria; Hypertension, Pulmonary; Monocrotaline; Ranolazine; Rats; Rats, Wistar | 2023 |
Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling.
Topics: Animals; beta Catenin; Catenins; Disease Models, Animal; Heart Failure; Mice; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Signal Transduction; Ventricular Function, Right; Ventricular Remodeling | 2023 |
Thoracic Spinal Cord Neuroinflammation as a Novel Therapeutic Target in Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Minocycline; Monocrotaline; Neuroinflammatory Diseases; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Spinal Cord | 2023 |
Nobiletin attenuates monocrotaline-induced pulmonary arterial hypertension through PI3K/Akt/STAT3 pathway.
Topics: Animals; Cytokines; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats | 2023 |
Maresin-1 protects against pulmonary arterial hypertension by improving mitochondrial homeostasis through ALXR/HSP90α axis.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Heat-Shock Proteins; Hypertension, Pulmonary; Hypoxia; Mice; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Vascular Remodeling | 2023 |
Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Heart Atria; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats | 2023 |
Skeletal muscle blood flow during exercise is reduced in a rat model of pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Lung; Monocrotaline; Muscle, Skeletal; Pulmonary Artery; Rats | 2023 |
Copaiba oil improves pulmonary nitric oxide bioavailability in monocrotaline-treated rats.
Topics: Animals; Antioxidants; Biological Availability; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Nitric Oxide; Oils, Volatile; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Wistar | 2023 |
[Panax notoginseng saponins improve monocrotaline-induced pulmonary arterial hypertension in rats by inhibiting ADAM10/Notch3 signaling pathway].
Topics: Animals; Caspase 3; Collagen; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Panax notoginseng; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Notch3; RNA, Messenger; Saline Solution; Saponins; Signal Transduction | 2023 |
Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Fibrosis; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2023 |
CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension.
Topics: Animals; CD146 Antigen; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Feedback, Physiological; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Knockout; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Pulmonary Artery; Rats; Severity of Illness Index; Up-Regulation; Vascular Remodeling | 2019 |
Effects of inorganic nitrate in a rat model of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Lung; Male; Monocrotaline; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitrites; Pulmonary Arterial Hypertension; Rats; Rats, Wistar; Superoxide Dismutase | 2020 |
Formononetin attenuates monocrotaline‑induced pulmonary arterial hypertension via inhibiting pulmonary vascular remodeling in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Disease Models, Animal; Hemodynamics; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Isoflavones; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Phosphatidylinositol 3-Kinases; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Survival Rate; Vascular Remodeling | 2019 |
Involvement of miR-200b-PKCα signalling in pulmonary hypertension in cor pulmonale model.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Protein Kinase C-alpha; Pulmonary Heart Disease; Signal Transduction | 2020 |
Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Arterial Pressure; Blueberry Plants; Disease Models, Animal; Lung; Male; Monocrotaline; Oxidation-Reduction; Plant Extracts; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Wistar | 2020 |
Carbenoxolone decreases monocrotaline‑induced pulmonary inflammation and pulmonary arteriolar remodeling in rats by decreasing the expression of connexins in T lymphocytes.
Topics: Animals; Biopsy; Carbenoxolone; Connexin 43; Connexins; Cytokines; Disease Models, Animal; Echocardiography; Gene Expression Regulation; Hemodynamics; Immunophenotyping; Inflammation Mediators; Male; Monocrotaline; Pneumonia; Pulmonary Fibrosis; Rats; T-Lymphocytes; Vascular Remodeling | 2020 |
MiR-135a inhibitor alleviates pulmonary arterial hypertension through β-Catenin/GSK-3β signaling pathway.
Topics: Animals; beta Catenin; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Injections, Intraperitoneal; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Trimethoxystilbene Reduces Nuclear Factor Kappa B, Interleukin-6, and Tumor Necrosis Factor-
Topics: Animals; Cytokines; Disease Models, Animal; Female; Immunohistochemistry; Interleukin-6; Lung; Male; Monocrotaline; NF-kappa B; Pregnancy; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2019 |
Alginate Oligosaccharide Alleviates Monocrotaline-Induced Pulmonary Hypertension via Anti-Oxidant and Anti-Inflammation Pathways in Rats.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertrophy, Right Ventricular; Injections, Intraperitoneal; Male; Malondialdehyde; Monocrotaline; Pulmonary Arterial Hypertension; Random Allocation; Rats; Vascular Remodeling | 2020 |
Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Pharmaceutical Preparations; Pulmonary Artery; Pyrazines; Rats; Rats, Sprague-Dawley | 2020 |
Aldosterone Contributed to Pulmonary Arterial Hypertension Development via Stimulating Aquaporin Expression and Pulmonary Arterial Smooth Muscle Cells Proliferation.
Topics: Aldosterone; Animals; Aquaporin 1; beta Catenin; Cell Proliferation; Disease Models, Animal; Female; Mineralocorticoid Receptor Antagonists; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Spironolactone | 2020 |
Aquaporin-2 expression in the kidney and urine is elevated in rats with monocrotaline-induced pulmonary heart disease.
Topics: Animals; Aquaporin 2; Arginine Vasopressin; Biomarkers; Disease Models, Animal; Humans; Hypertension, Pulmonary; Kidney; Male; Monocrotaline; Pulmonary Heart Disease; Rats; Renal Elimination | 2020 |
Ursolic Acid Improves Monocrotaline-Induced Right Ventricular Remodeling by Regulating Metabolism.
Topics: Animals; Apoptosis; Carnitine O-Palmitoyltransferase; Cells, Cultured; Disease Models, Animal; Energy Metabolism; Fatty Acids; Fibrosis; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; PPAR alpha; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Triterpenes; Ursolic Acid; Ventricular Function, Right; Ventricular Remodeling | 2020 |
Chrysin Alleviates Monocrotaline-Induced Pulmonary Hypertension in Rats Through Regulation of Intracellular Calcium Homeostasis in Pulmonary Arterial Smooth Muscle Cells.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Calcium Signaling; Disease Models, Animal; Flavonoids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats, Sprague-Dawley; TRPC Cation Channels; Vascular Remodeling; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2020 |
Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats.
Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Gene Silencing; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Prohibitins; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Repressor Proteins; RNA, Small Interfering | 2020 |
Early progression of pulmonary hypertension in the monocrotaline model in males is associated with increased lung permeability.
Topics: Animals; Blood Pressure; Capillary Permeability; Disease Models, Animal; Disease Progression; Endothelial Cells; Female; Heme; Hemolysis; HSP27 Heat-Shock Proteins; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Rats, Sprague-Dawley; Sex Characteristics; Tight Junctions | 2020 |
NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.
Topics: Acetamides; Animals; Antihypertensive Agents; Disease Models, Animal; Heart Ventricles; Hemodynamics; Humans; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrazines; Rats; Rats, Inbred WKY; Receptors, Thromboxane; Sildenafil Citrate; Vascular Remodeling | 2020 |
Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction.
Topics: Animals; Cell Movement; Cell Proliferation; Crown Ethers; Disease Models, Animal; Epidermal Growth Factor; ErbB Receptors; Hypertension, Pulmonary; In Vitro Techniques; MAP Kinase Signaling System; Microfilament Proteins; Monocrotaline; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteopontin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Quinazolines; Rats; Signal Transduction; Vascular Remodeling; Ventricular Function, Right; Ventricular Pressure; Vimentin | 2020 |
MicroRNA-483 amelioration of experimental pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; MicroRNAs; Monocrotaline; Rats | 2020 |
Early Intervention of Tongxinluo () on Right Ventricular Function Assessed by Echocardiography in Rats with Pulmonary Arterial Hypertension Induced by Monocrotaline.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Echocardiography; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Function, Right | 2020 |
Dihydroartemisinin Attenuates Pulmonary Hypertension Through Inhibition of Pulmonary Vascular Remodeling in Rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antihypertensive Agents; Artemisinins; Arterial Pressure; beta Catenin; Carrier Proteins; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling; Wnt Signaling Pathway | 2020 |
Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin.
Topics: Animals; Antioxidants; Carotenoids; Disease Models, Animal; Gene Expression Regulation; Hypertrophy, Right Ventricular; Lipid Peroxidation; Male; Mitochondrial Proteins; Monocrotaline; Oxidative Stress; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2020 |
3-Bromopyruvate ameliorates pulmonary arterial hypertension by improving mitochondrial metabolism.
Topics: Animals; Disease Models, Animal; Male; Mitochondria; Monocrotaline; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyruvates; Rats; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases | 2020 |
Perillyle alcohol and Quercetin ameliorate monocrotaline-induced pulmonary artery hypertension in rats through PARP1-mediated miR-204 down-regulation and its downstream pathway.
Topics: Animals; Disease Models, Animal; Down-Regulation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia-Inducible Factor 1, alpha Subunit; Male; MicroRNAs; Monocrotaline; Monoterpenes; NFATC Transcription Factors; Poly (ADP-Ribose) Polymerase-1; Pulmonary Artery; Quercetin; Rats; Rats, Wistar | 2020 |
In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression.
Topics: Administration, Inhalation; Animals; Antagomirs; Arterial Pressure; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Male; MicroRNAs; Monocrotaline; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Potassium Channels, Tandem Pore Domain; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Wistar; Signal Transduction; Vascular Remodeling | 2020 |
Optical capture and defibrillation in rats with monocrotaline-induced myocardial fibrosis 1 year after a single intravenous injection of adeno-associated virus channelrhodopsin-2.
Topics: Animals; Animals, Newborn; Arrhythmias, Cardiac; Cardiomyopathies; Channelrhodopsins; Dependovirus; Disease Models, Animal; Female; Fibrosis; Genetic Therapy; Heart Rate; Injections, Intravenous; Male; Monocrotaline; Myocardium; Optogenetics; Rats | 2021 |
Identification of novel biomarkers involved in pulmonary arterial hypertension based on multiple-microarray analysis.
Topics: Animals; Biomarkers; Computational Biology; Datasets as Topic; Disease Models, Animal; Gene Expression Profiling; Gene Regulatory Networks; Humans; Microarray Analysis; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; RNA, Messenger | 2020 |
Transplantation of viable mitochondria improves right ventricular performance and pulmonary artery remodeling in rats with pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Vascular Remodeling; Ventricular Remodeling | 2022 |
Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.
Topics: Acylation; Adult; Aged; AMP-Activated Protein Kinases; Animals; Cell Line; Cohort Studies; Colchicine; Diabetes Mellitus; Disease Models, Animal; Echocardiography; Gene Expression Regulation; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Hexosamines; Humans; Hypertrophy, Right Ventricular; Male; Metabolome; Middle Aged; Mitochondria; Monocrotaline; Myocytes, Cardiac; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right | 2020 |
Sympathetic innervation of canine pulmonary artery and morphometric and functional analysis in dehydromonocrotaline-induced models after pulmonary artery denervation.
Topics: Animals; Disease Models, Animal; Dogs; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Artery; Sympathectomy; Sympathetic Nervous System; Vascular Resistance | 2020 |
Preventive treatment with ginsenoside Rb1 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats and involves store-operated calcium entry inhibition.
Topics: Animals; Calcium; Disease Models, Animal; Ginsenosides; Male; Monocrotaline; Panax; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction | 2020 |
In situ Evidence of Collagen V and Interleukin-6/Interleukin-17 Activation in Vascular Remodeling of Experimental Pulmonary Hypertension.
Topics: Animals; Collagen; Disease Models, Animal; Hypertension, Pulmonary; Interleukin-17; Interleukin-6; Male; Monocrotaline; Rats; Rats, Wistar; Vascular Remodeling | 2020 |
The progression of pulmonary arterial hypertension induced by monocrotaline is characterized by lung nitrosative and oxidative stress, and impaired pulmonary artery reactivity.
Topics: Animals; Arterial Pressure; Disease Models, Animal; Disease Progression; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Nitrosative Stress; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pulmonary Edema; Rats, Wistar; Receptor, Endothelin A; Time Factors; Vascular Remodeling; Vasodilation | 2021 |
Sacubitril/valsartan treatment relieved the progression of established pulmonary hypertension in rat model and its mechanism.
Topics: Aminobutyrates; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Body Weight; Disease Models, Animal; Disease Progression; Drug Combinations; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Tetrazoles; Valsartan | 2021 |
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterial Pressure; Cytokines; Disease Models, Animal; Hypertrophy, Right Ventricular; Inflammation; Inflammation Mediators; Macrophages; Male; Monocrotaline; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Vascular Remodeling | 2021 |
Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Receptor for Advanced Glycation End Products | 2021 |
Mesenchymal Stromal Cell-derived Exosomes Attenuate Experimental Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Exosomes; Hypertension, Pulmonary; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Arterial Hypertension; Rats | 2021 |
Serum and pulmonary uric acid in pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Uric Acid | 2021 |
Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography.
Topics: Animals; Antihypertensive Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Monocrotaline; Predictive Value of Tests; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Synchrotrons; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX-5461 on pulmonary arterial hypertension and associated vascular remodelling.
Topics: Animals; Benzothiazoles; Cell Proliferation; Disease Models, Animal; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthyridines; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Polymerase I; Vascular Remodeling | 2021 |
Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Heart Failure; Heart Ventricles; Humans; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; RNA-Seq; Transcriptome; Ventricular Dysfunction, Right; Ventricular Remodeling | 2021 |
Soluble guanylate cyclase stimulator, trans-4-methoxy-β-nitrostyrene, has a beneficial effect in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterioles; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Signal Transduction; Soluble Guanylyl Cyclase; Styrenes; Vascular Remodeling; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Bmi-1 alleviates adventitial fibroblast senescence by eliminating ROS in pulmonary hypertension.
Topics: Adventitia; Animals; Cell Line; Cell Proliferation; Cellular Senescence; Disease Models, Animal; Fibroblasts; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Monocrotaline; Polycomb Repressive Complex 1; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2021 |
Phenotype and function of macrophage polarization in monocrotaline-induced pulmonary arterial hypertension rat model.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokines; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Macrophages; Male; Mannose Receptor; Monocrotaline; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Phenotype; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling | 2021 |
Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline via the TGF‑β1/p38 MAPK/CREB signaling pathway.
Topics: Animals; Anthocyanins; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Monocrotaline; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Rats; Transforming Growth Factor beta1; Vascular Remodeling | 2021 |
Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats.
Topics: Animals; Antirheumatic Agents; Chloroquine; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 9; Vascular Remodeling | 2021 |
Sildenafil improves right ventricular remodelling in monocrotaline-induced rats by decreasing myocardial apoptosis and activating peroxisome proliferator-activated receptors.
Topics: Animals; Apoptosis; Disease Models, Animal; Heart Ventricles; In Situ Nick-End Labeling; Monocrotaline; Myocardium; Peroxisome Proliferator-Activated Receptors; Phosphodiesterase 5 Inhibitors; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Ventricular Remodeling | 2021 |
Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension.
Topics: Animals; Antipsychotic Agents; Cardiovascular Agents; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Repositioning; Female; Forkhead Box Protein O3; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Survivin; Trifluoperazine | 2021 |
Sinusoidal Obstruction Syndrome Promotes Liver Metastatic Seeding of Colorectal Cancer Cells in a Rat Model.
Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Hepatic Veno-Occlusive Disease; Intercellular Adhesion Molecule-1; Liver Neoplasms; Male; Matrix Metalloproteinase 9; Monocrotaline; Rats, Inbred F344; Tumor Burden; Vascular Endothelial Growth Factor A | 2021 |
Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function.
Topics: Animals; Cannabidiol; Cell Proliferation; Disease Models, Animal; Glycolysis; Hypoxia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Reactive Oxygen Species; Vascular Remodeling | 2021 |
Pulmonary arterial hypertension induces the release of circulating extracellular vesicles with oxidative content and alters redox and mitochondrial homeostasis in the brains of rats.
Topics: Animals; Brain; Disease Models, Animal; Extracellular Vesicles; Homeostasis; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Oxidation-Reduction; Oxidative Stress; Pulmonary Arterial Hypertension; Rats; Rats, Wistar | 2021 |
Influence of atorvastatin on metabolic pattern of rats with pulmonary hypertension.
Topics: Animals; Arterial Pressure; Atorvastatin; Disease Models, Animal; Fatty Acids; Glycolysis; Humans; Hypertension, Pulmonary; Lung; Male; Metabolomics; Monocrotaline; Oxidation-Reduction; Pulmonary Artery; Rats; Vascular Remodeling | 2021 |
Quercetin, Perillyl Alcohol, and Berberine Ameliorate Right Ventricular Disorders in Experimental Pulmonary Arterial Hypertension: Effects on miR-204, miR-27a, Fibrotic, Apoptotic, and Inflammatory Factors.
Topics: Animals; Antioxidants; Apoptosis; Berberine; Disease Models, Animal; Fibrosis; Hypertrophy, Right Ventricular; Male; MicroRNAs; Monocrotaline; Monoterpenes; Pulmonary Arterial Hypertension; Quercetin; Rats; Rats, Wistar; Ventricular Function, Right | 2021 |
Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension.
Topics: Administration, Inhalation; Animals; Benzeneacetamides; Cells, Cultured; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Combinations; Drug Compounding; Enzyme Inhibitors; Glutaminase; Hemodynamics; Humans; Hypertension, Pulmonary; Intracellular Signaling Peptides and Proteins; Lung; Male; Mechanotransduction, Cellular; Monocrotaline; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Sprague-Dawley; Thiadiazoles; Time Factors; Vascular Remodeling; Ventricular Function, Right; Verteporfin; YAP-Signaling Proteins | 2021 |
Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure.
Topics: Animals; Chronic Disease; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Rats; Rats, Wistar; Ventricular Remodeling | 2021 |
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Topics: Actins; Administration, Oral; Animals; Apoptosis; Arterioles; Betaine; Cardiotonic Agents; Disease Models, Animal; Electrocardiography; Heart Failure; Heart Ventricles; Male; Monocrotaline; Proliferating Cell Nuclear Antigen; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Vascular Remodeling | 2021 |
Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats.
Topics: Adult; Age Factors; Animals; Calcium Channels; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Monocrotaline; Pulmonary Artery; Rats, Sprague-Dawley; Receptors, Calcium-Sensing | 2021 |
MicroRNA-663 prevents monocrotaline-induced pulmonary arterial hypertension by targeting TGF-β1/smad2/3 signaling.
Topics: Aged; Animals; Becaplermin; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Humans; Male; MicroRNAs; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Vascular Remodeling | 2021 |
Dysregulated zinc and sphingosine-1-phosphate signaling in pulmonary hypertension: Potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Cation Transport Proteins; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Lung; Lysophospholipids; Male; Microvessels; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Vascular Remodeling; Zinc | 2021 |
Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Genetic Predisposition to Disease; Hypertension, Pulmonary; Male; Monocrotaline; Nuclear Magnetic Resonance, Biomolecular; Parathyroid Hormone; Phenotype; Protein Binding; Pulmonary Artery; Rats, Sprague-Dawley; Rats, Transgenic; Receptors, Calcium-Sensing; RNA Interference; Signal Transduction; Transfection | 2017 |
Optimal Dose and Timing of Umbilical Stem Cells Treatment in Pulmonary Arterial Hypertensive Rats.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors | 2017 |
Treatment with platelet-derived growth factor (PDGF) and rock inhibitors is related to declined nerve growth factor (NGF) signaling in an experimental model of rat pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Imatinib Mesylate; Male; Monocrotaline; Nerve Growth Factor; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; rho-Associated Kinases; RNA, Messenger; Signal Transduction | 2017 |
Effects of Transplanted Human Cord Blood-Mononuclear Cells on Pulmonary Hypertension in Immunodeficient Mice and Their Distribution.
Topics: Animals; Cord Blood Stem Cell Transplantation; Disease Models, Animal; Fetal Blood; Heterografts; Humans; Hypertension, Pulmonary; Lung; Mice; Mice, Inbred BALB C; Mice, Nude; Monocrotaline; Pulmonary Artery | 2017 |
Galectin-3 mediates the pulmonary arterial hypertension-induced right ventricular remodeling through interacting with NADPH oxidase 4.
Topics: Adult; Animals; Biomarkers; Collagen Type III; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Galectin 3; Gene Knockdown Techniques; Heart Ventricles; Humans; Hypertension, Pulmonary; Male; Middle Aged; Monocrotaline; Myocardium; Myofibroblasts; NADPH Oxidase 4; Oxidative Stress; Primary Cell Culture; Rats; Transforming Growth Factor beta1; Up-Regulation; Ventricular Remodeling; Young Adult | 2017 |
Astragalus Polysaccharides Attenuate Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Astragalus Plant; Cytokines; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type III; Polysaccharides; Rats, Sprague-Dawley; Signal Transduction; Vascular Resistance | 2017 |
The protective effects of PCPA against monocrotaline-induced pulmonary arterial hypertension are mediated through the downregulation of NFAT-1 and NF-κB.
Topics: Animals; Disease Models, Animal; Fenclonine; Hypertension, Pulmonary; Male; Monocrotaline; NFATC Transcription Factors; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Tryptophan Hydroxylase | 2017 |
Osthole attenuates pulmonary arterial hypertension in monocrotaline‑treated rats.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Coumarins; Disease Models, Animal; Hypertension, Pulmonary; Lung; Male; Monocrotaline; NF-kappa B; Organ Size; Pulmonary Artery; Rats, Sprague-Dawley | 2017 |
Visceral adipose tissue-derived serine protease inhibitor prevents the development of monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Apoptosis; Disease Models, Animal; Fibrosis; Hypertension, Pulmonary; Intra-Abdominal Fat; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Wistar; Reactive Oxygen Species; Serine Proteinase Inhibitors; Signal Transduction | 2017 |
Preserved right ventricular integrity in a new telemetric rat model of severe pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Pulmonary Artery; Rats, Sprague-Dawley; Ventricular Function, Right | 2017 |
Cysteine-rich 61 (Cyr61) upregulated in pulmonary arterial hypertension promotes the proliferation of pulmonary artery smooth muscle cells.
Topics: Adult; Aged; Animals; Cell Proliferation; Cysteine-Rich Protein 61; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Signal Transduction | 2017 |
Phosphodiesterase III inhibitor attenuates rat sinusoidal obstruction syndrome through inhibition of platelet aggregation in Disse's space.
Topics: Animals; Antigens, CD34; Capillaries; Cilostazol; Disease Models, Animal; Epithelial Cells; Hepatic Veno-Occlusive Disease; Liver; Male; Monocrotaline; Phosphodiesterase 3 Inhibitors; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Platelet Membrane Glycoprotein IIb; Rats, Wistar; Tetrazoles; Time Factors | 2018 |
Expression of key enzymes in the mevalonate pathway are altered in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hemodynamics; Hypertension, Pulmonary; Metabolic Networks and Pathways; Mevalonic Acid; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; rhoA GTP-Binding Protein | 2017 |
Dihydromyricetin prevents monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Flavonols; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Vascular Remodeling | 2017 |
Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Indoles; Male; Monocrotaline; Nestin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pulmonary Artery; Pyrroles; Rats, Wistar; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting vascular remodeling in rats.
Topics: Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flavanones; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Situ Nick-End Labeling; Male; MAP Kinase Signaling System; Monocrotaline; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2018 |
Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.
Topics: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; Endothelium, Vascular; Enzyme Activators; Humans; Hypertension, Pulmonary; Imidazoles; Leucine; Lung; Male; Monocrotaline; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peptidyl-Dipeptidase A; Phosphorylation; Pulmonary Artery; Pyrans; Rats; Rats, Sprague-Dawley; Signal Transduction; Specific Pathogen-Free Organisms; Spiro Compounds; Xanthenes | 2017 |
Heart rate reduction improves biventricular function and interactions in experimental pulmonary hypertension.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Carvedilol; Disease Models, Animal; Drug Therapy, Combination; Heart Rate; Hypertension, Pulmonary; Ivabradine; Male; Monocrotaline; Rats, Sprague-Dawley; Recovery of Function; Time Factors; Ventricular Function, Left; Ventricular Function, Right | 2018 |
PPARγ Alleviates Right Ventricular Failure Secondary to Pulmonary Arterial Hypertension in Rats.
Topics: Animals; Apoptosis; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells; Heart Failure; Hypertension, Pulmonary; Lipid Metabolism; Male; Monocrotaline; Myocytes, Cardiac; PPAR gamma; Random Allocation; Rats, Sprague-Dawley | 2017 |
Exendin-4 improves cardiovascular function and survival in flow-induced pulmonary hypertension.
Topics: Actins; Animals; Antihypertensive Agents; Aorta; Arterial Pressure; Arteriovenous Shunt, Surgical; Cyclic AMP; Disease Models, Animal; Exenatide; Hypertension, Pulmonary; Interleukin-1beta; Male; Monocrotaline; Myosin Heavy Chains; Myosin Type II; Phosphorylation; Pulmonary Artery; Pulmonary Circulation; Rats, Sprague-Dawley; Regional Blood Flow; Vascular Remodeling; Vena Cava, Inferior; Ventricular Function, Right | 2018 |
Intratracheal Administration of Autologous Bone Marrow-Derived Cells Ameliorates Monocrotaline-Induced Pulmonary Vessel Remodeling and Lung Inflammation in Rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone Marrow Transplantation; Cells, Cultured; Cellular Microenvironment; Disease Models, Animal; Interleukin-10; Lung; Macrophage Activation; Macrophages, Alveolar; Male; Monocrotaline; Phenotype; Pneumonia; Rats, Sprague-Dawley; Receptors, Cell Surface; Transplantation, Autologous; Vascular Remodeling | 2018 |
Urantide improves the structure and function of right ventricle as determined by echocardiography in monocrotaline-induced pulmonary hypertension rat model.
Topics: Animals; Disease Models, Animal; Echocardiography, Doppler; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Peptide Fragments; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Urotensins; Ventricular Function, Right | 2019 |
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Topics: Animals; Becaplermin; Cell Movement; Cell Proliferation; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; HEK293 Cells; Histone Deacetylases; Humans; Hypertension, Pulmonary; Male; MicroRNAs; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Pulmonary Artery; Rats, Sprague-Dawley; Repressor Proteins; Signal Transduction; Vascular Remodeling | 2018 |
Trapidil improves hemodynamic, echocardiographic and redox state parameters of right ventricle in monocrotaline-induced pulmonary arterial hypertension model.
Topics: Animals; Blood Pressure; Calcium; Cardiac Catheterization; Cardiomegaly; Disease Models, Animal; Echocardiography; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Oxidation-Reduction; Rats, Wistar; Trapidil | 2018 |
A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Bone Morphogenetic Protein Receptors, Type II; Cell Movement; Cell Proliferation; Cell Shape; Disease Models, Animal; Endothelial Cells; Exosomes; Humans; Hypertension, Pulmonary; Lentivirus; Lung; Male; Monocrotaline; Mutation; Myocytes, Smooth Muscle; Protein Transport; Pulmonary Artery; Rats, Sprague-Dawley; Tumor Protein, Translationally-Controlled 1; Vascular Remodeling | 2018 |
Bucindolol attenuates the vascular remodeling of pulmonary arteries by modulating the expression of the endothelin-1 A receptor in rats with pulmonary arterial hypertension.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Echocardiography; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type III; Oxidative Stress; Propanolamines; Pulmonary Artery; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Vascular Remodeling | 2018 |
Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension.
Topics: Animals; Cytokines; Disease Models, Animal; Hypertension, Pulmonary; Male; Microglia; Monocrotaline; Paraventricular Hypothalamic Nucleus; Pulmonary Wedge Pressure; Rats; Rats, Sprague-Dawley | 2018 |
Cardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Estrogens; Exercise Tolerance; Female; Hypertension, Pulmonary; Monocrotaline; Muscle, Skeletal; Ovariectomy; Pulmonary Artery; Rats; Receptors, G-Protein-Coupled; Ventricular Dysfunction; Ventricular Remodeling | 2018 |
Betaine Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibiting Inflammatory Response.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Betaine; Biomarkers; Chemokine CCL2; Cytokines; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Inflammation Mediators; Male; Monocrotaline; Myocardium; NF-kappa B; Pulmonary Artery; Rats | 2018 |
Pulmonary Artery Hypertension Model in Rats by Monocrotaline Administration.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Dysfunction, Right | 2018 |
Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Enzyme Activation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; NF-kappa B; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2018 |
Comprehensive analysis of serum microRNAs in hepatic sinusoidal obstruction syndrome (SOS) in rats: implication as early phase biomarkers for SOS.
Topics: Animals; Biomarkers; Disease Models, Animal; Gene Expression; Hepatic Veno-Occlusive Disease; Hepatocytes; Liver; Male; MicroRNAs; Monocrotaline; Rats, Sprague-Dawley; Reproducibility of Results | 2018 |
Monocrotaline Suppresses RANKL-Induced Osteoclastogenesis In Vitro and Prevents LPS-Induced Bone Loss In Vivo.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Monocrotaline; Osteoclasts; Osteogenesis; Osteolysis; p38 Mitogen-Activated Protein Kinases; Protective Agents; Proto-Oncogene Proteins c-fos; Proton-Translocating ATPases; RANK Ligand; Skull | 2018 |
Effects of toceranib compared with sorafenib on monocrotaline-induced pulmonary arterial hypertension and cardiopulmonary remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Autophagy; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Monocrotaline; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pulmonary Artery; Pyrroles; Rats, Wistar; Signal Transduction; Sorafenib; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
P2X7 receptor is involved in lung injuries induced by ischemia-reperfusion in pulmonary arterial hypertension rats.
Topics: Animals; Cytokines; Disease Models, Animal; Humans; Hypertension, Pulmonary; Inflammation Mediators; Lung Injury; MAP Kinase Signaling System; Monocrotaline; Pulmonary Artery; Purinergic P2X Receptor Antagonists; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Reperfusion Injury | 2018 |
Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Pulmonary arterial hypertension induced by a novel method: Twice-intraperitoneal injection of monocrotaline.
Topics: Animals; Cardiac Output; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Injections, Intraperitoneal; Interleukin-6; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha | 2018 |
Analyses of long non-coding RNA and mRNA profiles in right ventricle myocardium of acute right heart failure in pulmonary arterial hypertension rats.
Topics: Animals; Computational Biology; Databases, Genetic; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Lipopolysaccharides; Male; Monocrotaline; Rats, Sprague-Dawley; RNA, Long Noncoding; RNA, Messenger; Transcriptome; Ventricular Dysfunction, Right; Ventricular Function, Right | 2018 |
Calcineurin/NFAT Signaling Modulates Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Apoptosis in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats.
Topics: Animals; Apoptosis; Calcineurin; Cell Hypoxia; Cell Movement; Cell Proliferation; Cyclosporine; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Smooth Muscle; Nerve Tissue Proteins; NFATC Transcription Factors; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Signal Transduction | 2018 |
Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Disease Models, Animal; Fabaceae; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; JNK Mitogen-Activated Protein Kinases; Male; Monocrotaline; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Plant Oils; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Signal Transduction; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Oxygen therapy may worsen the survival rate in rats with monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Oxygen Inhalation Therapy; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Survival Rate | 2018 |
Effects of Beet Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats.
Topics: Animals; Arterial Pressure; Beta vulgaris; Dietary Supplements; Disease Models, Animal; Fruit and Vegetable Juices; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Plant Roots; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right | 2019 |
Long noncoding RNA Hoxaas3 contributes to hypoxia-induced pulmonary artery smooth muscle cell proliferation.
Topics: Acetylation; Animals; Cell Cycle; Cell Hypoxia; Cell Line; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Histones; Homeodomain Proteins; Lysine; Male; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Processing, Post-Translational; Pulmonary Arterial Hypertension; Pulmonary Artery; RNA, Long Noncoding; Signal Transduction; Up-Regulation | 2019 |
17β-estradiol preserves right ventricular function in rats with pulmonary arterial hypertension: an echocardiographic and histochemical study.
Topics: Animals; Biomarkers; Disease Models, Animal; Echocardiography; Estradiol; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Natriuretic Peptide, Brain; Rats, Sprague-Dawley; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2019 |
MicroRNA-140-5p targeting tumor necrosis factor-α prevents pulmonary arterial hypertension.
Topics: Animals; Antagomirs; Base Sequence; Cell Hypoxia; Cell Movement; Cell Proliferation; Disease Models, Animal; Down-Regulation; HEK293 Cells; Humans; Male; MicroRNAs; Monocrotaline; Myocytes, Smooth Muscle; Phenotype; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation | 2019 |
Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice.
Topics: Animals; Blotting, Western; Cardiomyopathies; Disease Models, Animal; Down-Regulation; Fatty Acids; Heart Ventricles; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Myocardium; Oxidation-Reduction; Pyruvate Dehydrogenase Complex | 2019 |
miR‑371b‑5p inhibits endothelial cell apoptosis in monocrotaline‑induced pulmonary arterial hypertension via PTEN/PI3K/Akt signaling pathways.
Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Gene Expression Profiling; Genes, Reporter; Humans; Hypertension, Pulmonary; Male; MicroRNAs; Models, Biological; Monocrotaline; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Signal Transduction; Transcription Factor AP-1 | 2018 |
Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imines; Male; Mice, Knockout; Monocrotaline; Pulmonary Artery; Pyridines; Rats, Sprague-Dawley; Receptor, PAR-1; Thrombin; Vascular Remodeling; Ventricular Function, Left; Ventricular Remodeling | 2019 |
AOS ameliorates monocrotaline-induced pulmonary hypertension by restraining the activation of P-selectin/p38MAPK/NF-κB pathway in rats.
Topics: Alginates; Animals; Cell Nucleus; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; NF-kappa B; NF-KappaB Inhibitor alpha; Oligosaccharides; P-Selectin; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
CLIC4/Arf6 Pathway.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Antihypertensive Agents; Bone Morphogenetic Protein Receptors, Type II; Cells, Cultured; Chloride Channels; Disease Models, Animal; Endothelial Cells; Humans; Hypertension, Pulmonary; Hypoxia; Inflammation Mediators; Mice, Inbred C57BL; Mitochondrial Proteins; Molecular Targeted Therapy; Monocrotaline; Proteomics; Pulmonary Artery; Rats; RNA, Small Interfering; RNAi Therapeutics; Signal Transduction; Triazoles | 2019 |
Preventive Effect and Mechanism of Ethyl Acetate Extract of Sceptridium ternatum in Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Acetates; Animals; Disease Models, Animal; Female; Lung; Male; Monocrotaline; Plant Extracts; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Streptophyta | 2020 |
Therapeutic effects of the selective farnesoid X receptor agonist obeticholic acid in a monocrotaline-induced pulmonary hypertension rat model.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Chenodeoxycholic Acid; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 2019 |
A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.
Topics: Animals; Apelin Receptors; Disease Models, Animal; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley | 2019 |
Exploration of the Notch3-HES5 signal pathway in monocrotaline-induced pulmonary hypertension using rat model.
Topics: Animals; Arterial Pressure; Arterioles; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats, Sprague-Dawley; Receptor, Notch3; Repressor Proteins; Signal Transduction; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2019 |
Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMP/cGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Collagen Type I; Collagen Type I, alpha 1 Chain; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Epithelium; Fibronectins; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Inflammation; Lung; Monocrotaline; Phosphodiesterase 5 Inhibitors; Rats, Wistar; Transforming Growth Factor beta | 2019 |
Effect of estrogen on right ventricular remodeling of monocrotaline-induced pulmonary arterial hypertension in rats and its mechanism.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Heart Ventricles; Injections, Subcutaneous; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2019 |
Adipose-derived mesenchymal stromal cells improve hemodynamic function in pulmonary arterial hypertension: identification of microRNAs implicated in modulating endothelial function.
Topics: Adipose Tissue; Animals; Apoptosis; Cell Proliferation; Cell Survival; Coculture Techniques; Disease Models, Animal; Endothelial Cells; Endothelium; Gene Ontology; Hemodynamics; Humans; Hypertrophy, Left Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Vascular Endothelial Growth Factor A | 2019 |
The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley | 2019 |
LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension.
Topics: Actins; Adult; Animals; Antibodies, Neutralizing; Becaplermin; Case-Control Studies; Cell Dedifferentiation; Cell Proliferation; Collagen Type I; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Fibronectins; Gene Expression Regulation; Homeostasis; Humans; Integrin beta1; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mice; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Nuclear Proteins; Pulmonary Artery; Rats; Receptors, Platelet-Derived Growth Factor; RNA, Small Interfering; Signal Transduction; Tissue Culture Techniques; Trans-Activators | 2019 |
Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment.
Topics: Adenosine Triphosphatases; Administration, Oral; Adrenergic beta-1 Receptor Antagonists; Animals; Disease Models, Animal; Energy Metabolism; Heart Failure; Hypertension, Pulmonary; Male; Metoprolol; Mitochondria; Monocrotaline; Myocytes, Cardiac; Myofibrils; Oxidative Phosphorylation; Placebo Effect; Rats; Rats, Wistar; Reactive Oxygen Species; Ventricular Function, Right | 2019 |
Energy Metabolism in the Failing Right Ventricle: Limitations of Oxygen Delivery and the Creatine Kinase System.
Topics: Adrenergic beta-Antagonists; Animals; Creatine Kinase; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Heart Failure; Hypertension, Pulmonary; Hypoxia; Male; Mitochondria; Monocrotaline; Muscle Cells; Oxygen; Rats; Ventricular Dysfunction, Right | 2019 |
Cathepsin S promotes the development of pulmonary arterial hypertension.
Topics: Aged; Animals; Antihypertensive Agents; Cathepsins; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Pancreatic Elastase; PPAR gamma; Primary Cell Culture; Protease Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction | 2019 |
Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Protective Agents; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Silybin; Treatment Outcome | 2019 |
NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy.
Topics: Animals; Autophagy; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hemodynamics; Histone-Lysine N-Methyltransferase; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Vascular Remodeling | 2019 |
Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension.
Topics: Animals; Cell Line; Cyclin-Dependent Kinases; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Indoles; Lung; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Piperazines; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Pyrroles; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Treatment Outcome | 2019 |
Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension.
Topics: Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Metabolism; High-Throughput Screening Assays; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Male; Metabolome; Mice; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthoquinones; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Reactive Oxygen Species; Resorcinols; Transcription Factors | 2019 |
Attenuating Pulmonary Hypertension by Protecting the Integrity of Glycocalyx in Rats Model of Pulmonary Artery Hypertension.
Topics: Animals; Biomarkers; Disease Models, Animal; Glycocalyx; Heparin; Hyaluronic Acid; Hypertension, Pulmonary; Monocrotaline; Proteoglycans; Rats; Syndecan-1 | 2019 |
Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Female; Fibrosis; Heart; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Skeletal; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling; Ventricular Function, Right | 2019 |
Combination therapy improves vascular volume in female rats with pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Drug Therapy, Combination; Echocardiography; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Phenylpropionates; Pneumonectomy; Pulmonary Artery; Pyridazines; Rats; Rats, Sprague-Dawley; Tadalafil; Vascular Remodeling; Vasoconstriction; Ventricular Dysfunction, Right; X-Ray Microtomography | 2019 |
Circulating Plasma Metabolomic Profiles Differentiate Rodent Models of Pulmonary Hypertension and Idiopathic Pulmonary Arterial Hypertension Patients.
Topics: Adult; Animals; Biomarkers; Case-Control Studies; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Hypoxia; Male; Metabolomics; Methionine; Monocrotaline; Rats, Sprague-Dawley; Urea | 2019 |
A lymphocyte-dependent mode of action for imatinib mesylate in experimental pulmonary hypertension.
Topics: Animals; Apoptosis; Benzamides; Cytokines; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Immunomodulation; Leukocyte Count; Lymphocyte Depletion; Lymphocytes; Male; Monocrotaline; Myocytes, Cardiac; Piperazines; Pyrimidines; Rats; Rats, Inbred F344; Rats, Nude | 2013 |
Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.
Topics: Adult; Aged; Animals; Apoptosis; Arterial Pressure; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Glycation End Products, Advanced; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; S100 Proteins; Signal Transduction; STAT3 Transcription Factor; Transfection; Up-Regulation | 2013 |
Pyrrolidine dithiocarbamate attenuates the development of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Disease Models, Animal; Endothelium, Vascular; Erythrocytes; Familial Primary Pulmonary Hypertension; Hematocrit; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates | 2013 |
Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model.
Topics: Animals; Benzimidazoles; Carbocyanines; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Disease Models, Animal; Fluorescent Dyes; Free Radical Scavengers; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypoxia; Ion Channels; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitochondrial Proteins; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Pulmonary Artery; Rats; Reactive Oxygen Species; RNA, Small Interfering; Uncoupling Protein 2 | 2013 |
Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension.
Topics: Animals; Atrophy; Body Weight; Diaphragm; Disease Models, Animal; Eating; Hypertension, Pulmonary; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle Contraction | 2013 |
Pathophysiological roles of nuclear factor kappaB (NF-kB) in pulmonary arterial hypertension: effects of synthetic selective NF-kB inhibitor IMD-0354.
Topics: Animals; Antihypertensive Agents; Apoptosis; Benzamides; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Feedback, Physiological; Fibroblast Growth Factor 2; Hypertension, Pulmonary; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors; Tissue Plasminogen Activator; Transcription Factor RelA; Ventricular Function, Right; Ventricular Pressure | 2013 |
The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension.
Topics: Adolescent; Adult; Animals; Case-Control Studies; Cell Proliferation; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Imidazoles; Male; Monocrotaline; Nitric Oxide; Oxidative Stress; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sulfones; Triazines; Vardenafil Dihydrochloride; Young Adult | 2013 |
ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Arterial Pressure; Cytoprotection; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Naphthalenes; Neointima; Peptide Fragments; Peptidyl-Dipeptidase A; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Resorcinols; Severity of Illness Index; Time Factors; Vasodilation | 2013 |
Distinct loading conditions reveal various patterns of right ventricular adaptation.
Topics: Adaptation, Physiological; Animals; Arteriovenous Shunt, Surgical; Constriction; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Heart Failure; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Models, Cardiovascular; Monocrotaline; Myocardial Contraction; Physical Exertion; Pulmonary Artery; Rats; Rats, Wistar; Stroke Volume; Time Factors; Ultrasonography; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure | 2013 |
Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Gene Transfer Techniques; Heart Ventricles; HEK293 Cells; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Random Allocation; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Treatment Outcome | 2013 |
Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits.
Topics: Animals; Cyclooxygenase 1; Cytochrome P-450 Enzyme System; Disease Models, Animal; Endothelial Cells; Epoprostenol; Familial Primary Pulmonary Hypertension; Genetic Therapy; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Infusions, Intravenous; Intramolecular Oxidoreductases; Male; Monocrotaline; Rats; Rats, Inbred F344; Stem Cell Transplantation; Survival Rate; Tissue Engineering; Transfection; Treatment Outcome | 2013 |
Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice.
Topics: Animals; Apoptosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Lineage; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Mice; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Phenotype; RNA, Messenger; Stem Cells; Time Factors; Transport Vesicles | 2013 |
[Fasudil reverses monocrotaline-induced pulmonary hypertension in rats].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Male; Monocrotaline; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Treatment Outcome | 2013 |
Reversibility of the monocrotaline pulmonary hypertension rat model.
Topics: Animals; Arterioles; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Echocardiography; Hemodynamics; Hypertension, Pulmonary; Liver; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar | 2013 |
Suppression of cyclin D1 by plasmid-based short hairpin RNA ameliorated experimental pulmonary vascular remodeling.
Topics: Animals; Cell Proliferation; Cyclin D1; Disease Models, Animal; Down-Regulation; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Transfection | 2013 |
Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension.
Topics: Acetylcholine; Angiography; Animals; Disease Models, Animal; Endothelium, Vascular; Fluoxetine; Humans; Hypertension, Pulmonary; Lung; Male; Molecular Targeted Therapy; Monocrotaline; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Vasodilation | 2013 |
Imatinib attenuates monocrotaline pulmonary hypertension and has potent vasodilator activity in pulmonary and systemic vascular beds in the rat.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Benzamides; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Muscle, Smooth, Vascular; Phosphodiesterase 4 Inhibitors; Piperazines; Potassium Channel Blockers; Protein Kinase Inhibitors; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Vasoconstriction; Vasodilation; Vasodilator Agents | 2013 |
Soluble JAGGED1 inhibits pulmonary hypertension by attenuating notch signaling.
Topics: Adenoviridae; Animals; Binding Sites; Calcium-Binding Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypoxia; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Male; Membrane Proteins; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Phenotype; Promoter Regions, Genetic; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Notch1; Receptor, Notch3; Receptors, Notch; Serrate-Jagged Proteins; Signal Transduction; Time Factors; Trans-Activators; Transduction, Genetic; Transfection | 2013 |
Endothelial fate mapping in mice with pulmonary hypertension.
Topics: Actins; Alkylating Agents; Animals; Antigens, CD; Cadherins; Cell Lineage; Disease Models, Animal; Endothelium, Vascular; Hemodynamics; Humans; Hypertension, Pulmonary; Integrases; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocrotaline; Neointima; Pneumonectomy; Pulmonary Artery; von Willebrand Factor | 2014 |
Single intraperitoneal injection of monocrotaline as a novel large animal model of chronic pulmonary hypertension in Tibet minipigs.
Topics: Animals; Disease Models, Animal; Echocardiography; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Artery; Swine; Swine, Miniature | 2013 |
Telmisartan attenuates monocrotaline-induced pulmonary artery endothelial dysfunction through a PPAR gamma-dependent PI3K/Akt/eNOS pathway.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; PPAR gamma; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Telmisartan | 2014 |
Role for DNA damage signaling in pulmonary arterial hypertension.
Topics: Adult; Aged; Animals; Apoptosis; Benzimidazoles; Cell Proliferation; Cells, Cultured; Disease Models, Animal; DNA Damage; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Male; MicroRNAs; Middle Aged; Monocrotaline; NFATC Transcription Factors; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Signal Transduction | 2014 |
4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation.
Topics: Animals; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Fenclonine; Hypertension, Pulmonary; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Phenylalanine; Pneumonia; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tryptophan Hydroxylase; Tumor Necrosis Factor-alpha | 2014 |
Metabolomic analysis of arginine metabolism in acute hepatic injury in rats.
Topics: Alanine Transaminase; Animals; Arginase; Arginine; Biomarkers; Chemical and Drug Induced Liver Injury; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; Isocyanates; Male; Metabolomics; Monocrotaline; Naphthalenes; Ornithine; Rats; Rats, Inbred F344; Tetramethylphenylenediamine | 2014 |
Ethyl pyruvate ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Administration Schedule; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Hypertension, Pulmonary; Injections, Intraperitoneal; Interleukin-6; Male; Monocrotaline; Pyruvates; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2014 |
Palosuran treatment effective as bosentan in the treatment model of pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Quinolines; Rats; Rats, Wistar; Sulfonamides; Urea; Urotensins | 2014 |
Preventive and remedial application of etanercept attenuate monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Anti-Infective Agents; Arterial Pressure; Disease Models, Animal; Etanercept; Hypertension, Pulmonary; Interleukin-6; Lung; Male; Monocrotaline; Pulmonary Artery; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2016 |
Concurrent rho-kinase and tyrosine kinase platelet-derived growth factor inhibition in experimental pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Becaplermin; Benzamides; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Male; Monocrotaline; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrimidines; Rats; Rats, Wistar; Receptors, Platelet-Derived Growth Factor; rho-Associated Kinases; Ventricular Pressure | 2014 |
Myocardial and anti-inflammatory effects of chronic bosentan therapy in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Heart Ventricles; Hypertension, Pulmonary; Inflammation; Male; Monocrotaline; Rats; Rats, Wistar; Sulfonamides | 2014 |
Targeted delivery of pulmonary arterial endothelial cells overexpressing interleukin-8 receptors attenuates monocrotaline-induced pulmonary vascular remodeling.
Topics: Adenoviridae; Animals; Arterial Pressure; Cells, Cultured; Chemokine CCL2; Chemokines, CXC; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Female; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages; Monocrotaline; Neutrophil Infiltration; Neutrophils; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovariectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-8; Transduction, Genetic; Up-Regulation; Ventricular Function, Right; Ventricular Remodeling | 2014 |
Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension.
Topics: Adult; Aged, 80 and over; Animals; Antihypertensive Agents; Case-Control Studies; Cell Hypoxia; Cells, Cultured; Collagen; Disease Models, Animal; Elastin; Enzyme Inhibitors; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Isoenzymes; Male; Mice; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein-Lysine 6-Oxidase; Pulmonary Artery; Rats; RNA, Messenger; Ventricular Dysfunction, Right; Young Adult | 2014 |
Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model.
Topics: Animals; Blood Pressure; Body Weight; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelin-1; Guanylate Cyclase; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Nitric Oxide Synthase Type III; Piperazines; Piperidines; Pulmonary Artery; Purines; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfonamides; Vasoconstriction; Xanthines | 2014 |
NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling.
Topics: Adventitia; Animals; Antihypertensive Agents; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fibroblasts; HEK293 Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection; Up-Regulation | 2014 |
Fasudil reversed MCT-induced and chronic hypoxia-induced pulmonary hypertension by attenuating oxidative stress and inhibiting the expression of Trx1 and HIF-1α.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Hemodynamics; Hydrogen Peroxide; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Malondialdehyde; Monocrotaline; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thioredoxins; Vasodilator Agents | 2014 |
HMGB1 promotes the development of pulmonary arterial hypertension in rats.
Topics: Animals; Bronchoalveolar Lavage Fluid; Chemokine CCL2; Disease Models, Animal; DNA-Binding Proteins; Endothelin-1; Hemodynamics; HMGB1 Protein; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Interleukin-1beta; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vascular Resistance; Ventricular Dysfunction, Right | 2014 |
Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension.
Topics: Acetanilides; Animals; Calcium Signaling; Collagen; Disease Models, Animal; Fibrosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Membrane Potentials; Monocrotaline; Myocytes, Cardiac; Myosin Heavy Chains; Piperazines; Pulmonary Artery; Ranolazine; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Sodium Channels; Time Factors; Vascular Remodeling; Vascular Resistance; Ventricular Function, Right; Ventricular Remodeling | 2014 |
[Early treatment with hepatocyte growth factor improves pulmonary artery and right ventricular remodeling in rats with pulmonary artery hypertension by modulating cytokines expression].
Topics: Adenoviridae; Animals; Blood Pressure; Cytokines; Disease Models, Animal; Heart Ventricles; Hepatocyte Growth Factor; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Transfection; Ventricular Remodeling | 2014 |
[Hepatocyte growth factor intervention on rats with pulmonary hypertension and effect of endothelial cell membrane microparticles].
Topics: Adenoviridae; Animals; Blood Pressure; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Hepatocyte Growth Factor; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Transfection | 2014 |
Peptide-micelle hybrids containing fasudil for targeted delivery to the pulmonary arteries and arterioles to treat pulmonary arterial hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Inhalation; Animals; Antihypertensive Agents; Arterial Pressure; Arterioles; Cell-Penetrating Peptides; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Ethanolamines; Hypertension, Pulmonary; Injections, Intravenous; Magnetic Resonance Spectroscopy; Male; Micelles; Monocrotaline; Oligopeptides; Particle Size; Polyethylene Glycols; Pulmonary Artery; Rats, Sprague-Dawley; Solubility; Technology, Pharmaceutical | 2014 |
Regorafenib suppresses sinusoidal obstruction syndrome in rats.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Extracellular Signal-Regulated MAP Kinases; Hepatectomy; Hepatic Veno-Occlusive Disease; Liver; Male; Matrix Metalloproteinase 9; Monocrotaline; Necrosis; Phenylurea Compounds; Phosphorylation; Pyridines; Rats, Sprague-Dawley | 2015 |
Adipose-derived stem cells attenuate pulmonary arterial hypertension and ameliorate pulmonary arterial remodeling in monocrotaline-induced pulmonary hypertensive rats.
Topics: Adipose Tissue; Alkaloids; Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Treatment Outcome; Vascular Remodeling | 2015 |
Rosuvastatin, sildenafil and their combination in monocrotaline-induced pulmonary hypertension in rat.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Biomarkers; Cholesterol, HDL; Disease Models, Animal; Drug Therapy, Combination; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Natriuretic Peptide, Brain; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Purines; Pyrimidines; Rats, Wistar; Rosuvastatin Calcium; Sildenafil Citrate; Sulfonamides; Time Factors; Vascular Endothelial Growth Factor A; Vascular Remodeling; Vasodilator Agents; Ventricular Function, Right; Ventricular Pressure | 2014 |
Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.
Topics: Animals; Apelin; Arterioles; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells; Fibroblast Growth Factor 2; Hemodynamics; Histone Deacetylase Inhibitors; Hydroxamic Acids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Intercellular Signaling Peptides and Proteins; Male; MEF2 Transcription Factors; MicroRNAs; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Transcription, Genetic | 2015 |
Determination of the effects of pulmonary arterial hypertension and therapy on the cardiovascular system of rats by impedance cardiography.
Topics: Animals; Blood Pressure; Bosentan; Cardiography, Impedance; Disease Models, Animal; Drug Therapy, Combination; Echocardiography; Endothelin Receptor Antagonists; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Purines; Rats, Wistar; Sildenafil Citrate; Sulfonamides | 2014 |
Sex differences in stretch-dependent effects on tension and Ca(2+) transient of rat trabeculae in monocrotaline pulmonary hypertension.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Endothelium, Vascular; Female; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Pulmonary Veins; Rats; Rats, Wistar; Sex Characteristics | 2015 |
Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
Topics: Animals; Cells, Cultured; Collagen Type III; Connective Tissue Growth Factor; Disease Models, Animal; Endothelial Cells; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Intraperitoneal; Lung; Male; Mice; Monocrotaline; Receptor, Notch3; Receptors, Notch; Signal Transduction; Thymosin | 2014 |
Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Glycyrrhizic Acid; HMGB1 Protein; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle, Smooth, Vascular; Pneumonia; Pulmonary Artery; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right | 2014 |
Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3 inflammasome activation in rats.
Topics: Animals; Blotting, Western; Carrier Proteins; Disease Models, Animal; Ellagic Acid; Enzyme-Linked Immunosorbent Assay; Hypertension, Pulmonary; Inflammasomes; Male; Monocrotaline; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 2015 |
Encapsulation of beraprost sodium in nanoparticles: analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension.
Topics: Animals; Capillary Permeability; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Epoprostenol; Hypertension, Pulmonary; Lactic Acid; Male; Mice, Inbred C57BL; Monocrotaline; Nanoparticles; Polyesters; Polyethylene Glycols; Polymers; Pulmonary Artery; Rats, Wistar; Rhodamines | 2015 |
Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Disease Models, Animal; Endothelium, Vascular; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Lung Injury; Macrophages; Male; Mevalonic Acid; Monocrotaline; Nitric Oxide Synthase Type III; Oxygen; Phosphorylation; Pulmonary Edema; Pyrimidines; Rats, Sprague-Dawley; Reperfusion Injury; Rosuvastatin Calcium; Sulfonamides; Up-Regulation | 2015 |
Effects of captopril on cardiovascular reflexes and respiratory mechanisms in rats submitted to monocrotaline-induced pulmonary arterial hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Baroreflex; Captopril; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Wistar; Vascular Remodeling | 2015 |
Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imidazoles; Lung; Male; Monocrotaline; Myocardium; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pulmonary Fibrosis; Pyridines; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Signal Transduction; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2015 |
Endothelial-to-mesenchymal transition in pulmonary hypertension.
Topics: Actins; Animals; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Cell Movement; Cell Transdifferentiation; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Gene Expression Profiling; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Mesoderm; Monocrotaline; Mutation; Rats; RNA, Messenger; Sirolimus; Vascular Remodeling; Vimentin | 2015 |
Therapeutic effects of baicalin on monocrotaline-induced pulmonary arterial hypertension by inhibiting inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cytokines; Disease Models, Animal; Flavonoids; Hypertension, Pulmonary; Immunohistochemistry; Lung; Monocrotaline; Pulmonary Artery; Rats, Wistar; Vascular Remodeling | 2015 |
Pathophysiology of infantile pulmonary arterial hypertension induced by monocrotaline.
Topics: Animals; Animals, Newborn; Collagen Type I; Collagen Type III; Disease Models, Animal; Endothelin-1; Female; Heart; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Myocytes, Cardiac; Natriuretic Peptide, Brain; Pyrrolizidine Alkaloids; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Transcription Factors | 2015 |
Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hemodynamics; Histone Deacetylase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Valproic Acid | 2015 |
Abnormal expression of vesicular transport proteins in pulmonary arterial hypertension in monocrotaline-treated rats.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Caspase 3; Caveolin 1; Disease Models, Animal; Enzyme Activation; Gene Expression; Hypertension, Pulmonary; Male; Monocrotaline; N-Ethylmaleimide-Sensitive Proteins; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; RNA, Messenger; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; Vesicular Transport Proteins | 2015 |
Calorie Restriction Attenuates Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
Topics: Acetylation; Adenoviridae; Animals; Arterial Pressure; Caloric Restriction; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Genetic Vectors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Time Factors; Transduction, Genetic; Vascular Remodeling; Vasodilation; Vasodilator Agents | 2015 |
Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure?
Topics: Administration, Inhalation; Animals; Arterial Pressure; Cardiotonic Agents; Disease Models, Animal; Disease Progression; Dobutamine; Energy Metabolism; Heart Failure; Hexokinase; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; L-Lactate Dehydrogenase; Male; Mitochondria, Heart; Monocrotaline; Oxygen; Oxygen Consumption; Protoporphyrins; Pulmonary Artery; Rats, Wistar; Ventricular Dysfunction, Right; Ventricular Function, Right | 2015 |
Nebivolol for improving endothelial dysfunction, pulmonary vascular remodeling, and right heart function in pulmonary hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Benzopyrans; Cell Communication; Cell Culture Techniques; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Ethanolamines; Humans; Hypertension, Pulmonary; Male; Metoprolol; Monocrotaline; Myocytes, Smooth Muscle; Nebivolol; Pulmonary Artery; Rats; Rats, Wistar; Vascular Remodeling | 2015 |
Ginsenoside Rb1 attenuates agonist-induced contractile response via inhibition of store-operated calcium entry in pulmonary arteries of normal and pulmonary hypertensive rats.
Topics: Animals; Calcium; Calcium Channels; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Endothelin-1; Gadolinium; Ginsenosides; Hypertension, Pulmonary; Indoles; Male; Monocrotaline; Muscle Contraction; Myocytes, Smooth Muscle; Nifedipine; Panax; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum | 2015 |
Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats With Monocrotaline-induced Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nicorandil; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 5 Inhibitors; Pyridazines; Rats, Wistar; Recovery of Function; Severity of Illness Index; Sildenafil Citrate; Vasodilator Agents; Ventricular Dysfunction, Right; Ventricular Function, Right | 2015 |
Novel assessment of haemodynamic kinetics with acute exercise in a rat model of pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Blood Pressure Monitoring, Ambulatory; Disease Models, Animal; Enzyme Activation; Exercise Therapy; Glycolysis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kinetics; Male; Monocrotaline; Muscle, Skeletal; Myocardium; Nitric Oxide Synthase Type III; Predictive Value of Tests; Pulmonary Artery; Rats, Sprague-Dawley; Telemetry; Ventricular Function, Right; Ventricular Pressure | 2015 |
Delivery of imatinib-incorporated nanoparticles into lungs suppresses the development of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Benzamides; Cells, Cultured; Disease Models, Animal; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nanoparticles; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor | 2015 |
Aerobic Exercise Promotes a Decrease in Right Ventricle Apoptotic Proteins in Experimental Cor Pulmonale.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Disease Models, Animal; Echocardiography; Hemodynamics; Hydrogen Peroxide; Hypertrophy, Right Ventricular; Male; Monocrotaline; Physical Conditioning, Animal; Pulmonary Artery; Pulmonary Heart Disease; Rats, Wistar; Vascular Resistance; Ventricular Function, Right; Ventricular Remodeling | 2015 |
The Effect of Umbilical Cord Blood Derived Mesenchymal Stem Cells in Monocrotaline-induced Pulmonary Artery Hypertension Rats.
Topics: Animals; Cytokines; Disease Models, Animal; Endothelin-1; Fetal Blood; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Matrix Metalloproteinase 2; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A | 2015 |
The effects of mycophenolate mofetil on cytokines and their receptors in pulmonary arterial hypertension in rats.
Topics: Animals; Blood Pressure; Cell Proliferation; Cytokines; Disease Models, Animal; Endothelin-1; Fibroblast Growth Factor 2; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Mycophenolic Acid; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Cytokine; Receptors, Fibroblast Growth Factor | 2015 |
Anti-Endothelin Receptor Type A Autoantibodies in Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension.
Topics: Adult; Animals; Autoantibodies; Cell Proliferation; Cohort Studies; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Profiling; Humans; Hypertension, Pulmonary; In Vitro Techniques; Lupus Erythematosus, Systemic; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Permeability; Proto-Oncogene Proteins c-sis; Rats; Receptor, Endothelin A; Receptor, Platelet-Derived Growth Factor beta; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Vascular Endothelial Growth Factor A | 2015 |
Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Cell Proliferation; Disease Models, Animal; Hydrogen; Hypertension, Pulmonary; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NFATC Transcription Factors; Phosphorylation; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Vascular Remodeling | 2015 |
The length-dependent activation of contraction is equally impaired in impuberal male and female rats in monocrotaline-induced right ventricular failure.
Topics: Action Potentials; Age Factors; Animals; Calcium Signaling; Disease Models, Animal; Female; Heart Failure; Heart Ventricles; Isometric Contraction; Male; Monocrotaline; Myocardial Contraction; Rats, Wistar; Sex Factors; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right | 2015 |
[Effect of sesamin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary hypertension].
Topics: Animals; Dioxoles; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Hypertension, Pulmonary; Lignans; Lung; Male; Membrane Glycoproteins; Monocrotaline; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2015 |
Inhibition of Notch3 prevents monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Notch3; Receptors, Notch; Signal Transduction | 2015 |
Activation of the phosphatidylinositol 3-kinase/Akt pathway is involved in lipocalin-2-promoted human pulmonary artery smooth muscle cell proliferation.
Topics: Acute-Phase Proteins; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Humans; Hypertension, Pulmonary; Lipocalin-2; Lipocalins; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Up-Regulation; Vascular Remodeling | 2015 |
Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspase 3; Cells, Cultured; Cytokines; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; I-kappa B Proteins; Inflammation Mediators; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pulmonary Artery; Rats; Rats, Wistar; Signal Transduction; Transcription Factor RelA; Vascular Remodeling | 2015 |
Farnesoid-X-receptor expression in monocrotaline-induced pulmonary arterial hypertension and right heart failure.
Topics: Animals; Disease Models, Animal; Gene Expression; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Vascular Remodeling; Ventricular Remodeling | 2015 |
Percutaneous Carbon Dioxide Treatment Using a Gas Mist Generator Attenuates the Development of Right Ventricular Dysfunction in Monocrotaline-induced Pulmonary Hypertensive Rats.
Topics: Aerosols; Animals; Carbon Dioxide; Cardiovascular Agents; Disease Models, Animal; Hemodynamics; HSP72 Heat-Shock Proteins; Hypertension, Pulmonary; Male; Monocrotaline; Myocardium; Nebulizers and Vaporizers; Nitric Oxide Synthase Type III; Phosphorylation; Rats, Wistar; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right | 2015 |
Tetrandrine prevents monocrotaline-induced pulmonary arterial hypertension in rats through regulation of the protein expression of inducible nitric oxide synthase and cyclic guanosine monophosphate-dependent protein kinase type 1.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Benzylisoquinolines; Catalase; Cell Proliferation; Cyclic GMP-Dependent Protein Kinase Type I; Disease Models, Animal; Glutathione; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Oxidative Stress; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase; Time Factors; Vascular Remodeling; Ventricular Remodeling | 2016 |
Inhibition of FGFR Signaling With PD173074 Ameliorates Monocrotaline-induced Pulmonary Arterial Hypertension and Rescues BMPR-II Expression.
Topics: Adolescent; Adult; Animals; Apoptosis; Arterioles; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblast Growth Factor 2; Heart Ventricles; Hemodynamics; Humans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; Signal Transduction; Smad Proteins, Receptor-Regulated; Time Factors; Vascular Remodeling; Young Adult | 2015 |
Exercise preconditioning prevents MCT-induced right ventricle remodeling through the regulation of TNF superfamily cytokines.
Topics: Animals; Cytokines; Disease Models, Animal; Exercise Therapy; Male; Monocrotaline; Myocardium; Physical Exertion; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2016 |
Effect of all-trans retinoic acids (ATRA) on the expression of α-smooth muscle actin (α-SMA) in the lung tissues of rats with pulmonary arterial hypertension (PAH).
Topics: Actins; Animals; Disease Models, Animal; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tretinoin | 2015 |
Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats.
Topics: Animals; Disease Models, Animal; Gene Expression; Glucuronidase; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Rats; Rats, Wistar | 2016 |
Time course of ubiquitin-proteasome and macroautophagy-lysosome pathways in skeletal muscle in rats with heart failure.
Topics: Animals; Autophagy; Body Weight; Disease Models, Animal; Heart; Heart Failure; Lung; Lysosomes; Male; Monocrotaline; Muscle, Skeletal; Muscular Atrophy; Organ Size; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Ubiquitin | 2015 |
Ruscogenin exerts beneficial effects on monocrotaline-induced pulmonary hypertension by inhibiting NF-κB expression.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Humans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Platelet-Derived Growth Factor; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spirostans | 2015 |
Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2015 |
Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline.
Topics: Action Potentials; Animals; Arterial Pressure; Cell Proliferation; Disease Models, Animal; Dogs; Gene Expression Regulation; Hypertension, Pulmonary; Monocrotaline; Neural Conduction; Pulmonary Artery; RNA, Messenger; Sympathectomy; Sympathetic Nervous System; Time Factors; Vascular Remodeling; Vascular Resistance; Vasoconstriction | 2015 |
Pioglitazone alleviates cardiac and vascular remodelling and improves survival in monocrotaline induced pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages, Alveolar; Male; Monocrotaline; Myocytes, Cardiac; Natriuretic Peptide, Brain; Osteopontin; Pioglitazone; PPAR gamma; Pulmonary Artery; Rats, Sprague-Dawley; Thiazolidinediones; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2016 |
Intratracheal Administration of Prostacyclin Analogue-incorporated Nanoparticles Ameliorates the Development of Monocrotaline and Sugen-Hypoxia-induced Pulmonary Arterial Hypertension.
Topics: Adolescent; Adult; Animals; Cell Hypoxia; Cell Proliferation; Child; Disease Models, Animal; Drug Delivery Systems; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Smooth Muscle; Nanoparticles; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors; Young Adult | 2016 |
[Effect of chrysin on expression of NOX4 and NF-κB in right ventricle of monocrotaline-induced pulmonary arterial hypertension of rats].
Topics: Animals; Blotting, Western; Collagen; Disease Models, Animal; Flavonoids; Heart Ventricles; Hypertension, Pulmonary; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Rats; Ventricular Remodeling | 2015 |
Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis.
Topics: Animals; Apoptosis; Arterial Pressure; Dichloroacetic Acid; Disease Models, Animal; Heart Ventricles; Hemodynamics; Male; Mitochondria; Monocrotaline; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2016 |
Reversal of MicroRNA Dysregulation in an Animal Model of Pulmonary Hypertension.
Topics: Animals; Antagomirs; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Gene Expression Regulation; Genetic Therapy; Humans; Hypertension, Pulmonary; Intramolecular Oxidoreductases; Lung; MicroRNAs; Monocrotaline; Oligonucleotides; Rats, Sprague-Dawley | 2016 |
Therapeutic Benefits of Induced Pluripotent Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Adult; Animals; Cells, Cultured; Culture Media, Conditioned; Cytokines; Disease Models, Animal; Down-Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation; Interferon-gamma; Interleukins; Lung; Macrophages; Male; Monocrotaline; NF-kappa B; Phosphorylation; Pluripotent Stem Cells; Pulmonary Artery; Rats | 2016 |
Development of a servo pump system for in vivo loading of pathological pulmonary artery impedance on the right ventricle of normal rats.
Topics: Animals; Arterial Pressure; Blood Flow Velocity; Cardiac Pacing, Artificial; Disease Models, Animal; Electronics, Medical; Equipment Design; Hemodynamics; Hypertension, Pulmonary; Male; Models, Cardiovascular; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats, Sprague-Dawley; Regional Blood Flow; Time Factors; Vascular Resistance; Ventricular Function, Right | 2016 |
Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.
Topics: Animals; Blood Pressure; Carnitine; Disease Models, Animal; Disease Progression; Glutathione; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Metabolic Networks and Pathways; Metabolome; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors | 2016 |
Modafinil improves monocrotaline-induced pulmonary hypertension rat model.
Topics: Animals; Benzhydryl Compounds; Body Weight; Cyclic AMP; Disease Models, Animal; Endothelin-1; Gene Expression Regulation; Heart Ventricles; Humans; Hypertension, Pulmonary; Intermediate-Conductance Calcium-Activated Potassium Channels; Male; Modafinil; Monocrotaline; Myocytes, Smooth Muscle; Pressure; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Vasoconstriction | 2016 |
Activation of AMPK Prevents Monocrotaline-Induced Extracellular Matrix Remodeling of Pulmonary Artery.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Enzyme Activation; Extracellular Matrix; Hypertension, Pulmonary; Male; Matrix Metalloproteinase 2; Metformin; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Vascular Remodeling | 2016 |
Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice.
Topics: Animals; Case-Control Studies; Cell-Derived Microparticles; Cells, Cultured; Disease Models, Animal; Exosomes; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; MicroRNAs; Monocrotaline; Pulmonary Artery; Vascular Remodeling | 2016 |
(1)H NMR-Based Analysis of Serum Metabolites in Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats.
Topics: Animals; Arterial Pressure; Disease Models, Animal; Disease Progression; Energy Metabolism; Glycolysis; Hypertension, Pulmonary; Lipid Metabolism; Male; Metabolome; Methionine; Monocrotaline; Proton Magnetic Resonance Spectroscopy; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2016 |
Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by activating PI3K/Akt/eNOS signaling.
Topics: Animals; Blotting, Western; Disease Models, Animal; Genistein; Heart Ventricles; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phytoestrogens; Proto-Oncogene Proteins c-akt; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction | 2017 |
Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Everolimus; Hypertension, Pulmonary; Male; Matrix Metalloproteinases; Monocrotaline; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Thiazoles; Vasodilator Agents | 2017 |
Fractal Dimension in Quantifying Experimental-Pulmonary-Hypertension-Induced Cardiac Dysfunction in Rats.
Topics: Animals; Disease Models, Animal; Echocardiography; Fractals; Heart Failure; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Cardiac; Rats, Wistar; Reference Values; Reproducibility of Results; Stroke Volume; Ventricular Dysfunction, Left; Ventricular Dysfunction, Right | 2016 |
4-Phenylbutyric Acid Induces Protection against Pulmonary Arterial Hypertension in Rats.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum Stress; Gene Expression; Heat-Shock Proteins; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Phenylbutyrates; Protective Agents; Pulmonary Artery; Random Allocation; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction | 2016 |
Preventive aerobic training exerts a cardioprotective effect on rats treated with monocrotaline.
Topics: Aerobiosis; Animals; Cardiotonic Agents; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Physical Conditioning, Animal; Rats, Wistar | 2016 |
Thymoquinone attenuates monocrotaline-induced pulmonary artery hypertension via inhibiting pulmonary arterial remodeling in rats.
Topics: Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Benzoquinones; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome; Vascular Remodeling | 2016 |
Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals.
Topics: Animals; Chlorogenic Acid; Disease Models, Animal; Early Growth Response Protein 1; Hepatic Veno-Occlusive Disease; Male; Mitogen-Activated Protein Kinase Kinases; Monocrotaline; NF-E2-Related Factor 2; NF-kappa B; Phosphatidylinositol 3-Kinases; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptors; Transcriptional Activation | 2016 |
Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Case-Control Studies; Disease Models, Animal; Disease Progression; Endothelin-1; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Liver; Lung; Male; Middle Aged; Monocrotaline; Niacinamide; Nicotinamide N-Methyltransferase; Nitric Oxide; Rats, Wistar; Signal Transduction; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right | 2016 |
Sinusoidal obstruction syndrome in the animal model: influence on liver surgery.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Combined Modality Therapy; Disease Models, Animal; Hepatectomy; Hepatic Veno-Occlusive Disease; Hypoxia; Liver Function Tests; Liver Neoplasms; Male; Monocrotaline; Organoplatinum Compounds; Oxaliplatin; Rats; Rats, Sprague-Dawley | 2017 |
Monocrotaline-Induced Pulmonary Hypertension Involves Downregulation of Antiaging Protein Klotho and eNOS Activity.
Topics: Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Down-Regulation; Glucuronidase; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Klotho Proteins; Male; Mesenchymal Stem Cells; Monocrotaline; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sirtuin 1; Transfection | 2016 |
Sulfur Dioxide Protects Against Collagen Accumulation in Pulmonary Artery in Association With Downregulation of the Transforming Growth Factor β1/Smad Pathway in Pulmonary Hypertensive Rats.
Topics: Animals; Aspartate Aminotransferases; Cells, Cultured; Collagen; Disease Models, Animal; Down-Regulation; Fibroblasts; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Sulfur Dioxide; Transforming Growth Factor beta1; Vascular Remodeling | 2016 |
Lung tissue remodelling in MCT-induced pulmonary hypertension: a proposal for a novel scoring system and changes in extracellular matrix and fibrosis associated gene expression.
Topics: Actins; Animals; Disease Models, Animal; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Fibrosis; Gene Expression Profiling; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Lung; Monocrotaline; Oligonucleotide Array Sequence Analysis; Rats, Sprague-Dawley; Severity of Illness Index; Tenascin; Vascular Remodeling | 2016 |
Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model.
Topics: Animals; Disease Models, Animal; Fibrosis; Galectin 3; Hypertension, Pulmonary; Male; Matrix Metalloproteinase 9; Monocrotaline; Rats; Rats, Wistar; STAT3 Transcription Factor; Transforming Growth Factor beta1; Vascular Diseases | 2017 |
Inhibition of endocan attenuates monocrotaline-induced connective tissue disease related pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Cells, Cultured; Connective Tissue; Disease Models, Animal; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Proteoglycans; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Tumor Necrosis Factor-alpha; Vascular Remodeling | 2017 |
Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension.
Topics: Animals; Atrioventricular Node; Disease Models, Animal; Down-Regulation; Echocardiography; Electrocardiography; Electrophysiologic Techniques, Cardiac; Heart Block; Hypertension, Pulmonary; Ion Channels; Male; Monocrotaline; Polymerase Chain Reaction; Rats; Rats, Wistar; Transcriptome | 2016 |
HMGB1 down-regulation mediates terameprocol vascular anti-proliferative effect in experimental pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Hemodynamics; HMGB1 Protein; Hypertension; Male; Masoprocol; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Interaction Maps; Proteomics; Pulmonary Artery; Rats, Wistar; Recovery of Function; Time Factors; Vascular Remodeling; Ventricular Function, Left; Ventricular Function, Right; Ventricular Remodeling | 2017 |
Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
Topics: Animals; Arterial Pressure; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Focal Adhesion Kinase 1; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Integrin alphaVbeta3; Male; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Osteoprotegerin; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; RNA Interference; Severity of Illness Index; Signal Transduction; Transfection; Vascular Remodeling; Walk Test | 2017 |
Downhill exercise training in monocrotaline-injected rats: Effects on echocardiographic and haemodynamic variables and survival.
Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Echocardiography; Heart Ventricles; Hemodynamics; Male; Monocrotaline; Physical Conditioning, Animal; Rats; Rats, Wistar | 2017 |
Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension.
Topics: Actins; Animals; Antioxidants; Biomimetic Materials; Catalase; Diaphragm; Disease Models, Animal; Glutathione; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Contraction; Muscle Weakness; Organometallic Compounds; Oxidative Stress; Rats; Rats, Wistar; Salicylates; Superoxide Dismutase | 2017 |
Effects of aerobic exercise training on metabolism of nitric oxide and endothelin-1 in lung parenchyma of rats with pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Parenchymal Tissue; Physical Conditioning, Animal; Rats; Rats, Wistar; Vascular Resistance | 2017 |
Effects of renal denervation on monocrotaline induced pulmonary remodeling.
Topics: Airway Remodeling; Animals; Blood Vessels; Denervation; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Kaplan-Meier Estimate; Kidney; Lung; Male; Monocrotaline; Rats; Renin-Angiotensin System | 2017 |
Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease.
Topics: Animals; Arterial Pressure; Chronic Disease; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Severity of Illness Index; Vascular Resistance | 2017 |
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Immunohistochemistry; Mice; Monocrotaline; Pulmonary Artery; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.
Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; B-Lymphocytes; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Chemokines; Disease Models, Animal; Endothelium, Vascular; Heterozygote; Hypertension, Pulmonary; Inflammation; Lung; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocrotaline; Mutation; Pressure; Pulmonary Artery; Receptors, Transforming Growth Factor beta; RNA, Messenger; T-Lymphocytes; Time Factors; Transduction, Genetic; Ventricular Function, Right | 2008 |
Reliable experimental model of hepatic veno-occlusive disease caused by monocrotaline.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Hepatic Veno-Occlusive Disease; Immunohistochemistry; Liver; Liver Regeneration; Male; Monocrotaline; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Time Factors | 2008 |
[Quantitative and functional changes of circulating endothelial progenitor cells in dogs with dehydromonocrotaline-induced pulmonary artery hypertension].
Topics: Animals; Cell Count; Cells, Cultured; Disease Models, Animal; Dogs; Endothelial Cells; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Circulation; Stem Cells | 2008 |
CPU0213, a non-selective ETA/ETB receptor antagonist, improves pulmonary arteriolar remodeling of monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Arterioles; Calcium Channel Blockers; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Female; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nifedipine; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B | 2009 |
Captopril attenuates matrix metalloproteinase-2 and -9 in monocrotaline-induced right ventricular hypertrophy in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blotting, Western; Captopril; Disease Models, Animal; Echocardiography; Fibrosis; Gene Expression Regulation; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Wistar; Ventricular Dysfunction, Right | 2008 |
Marrow cell infusion attenuates vascular remodeling in a murine model of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Blood Vessels; Bone Marrow Cells; Bone Marrow Transplantation; Disease Models, Animal; Female; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Sodium Chloride; Vimentin; Whole-Body Irradiation | 2009 |
Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Injections, Subcutaneous; Lung; Lung Compliance; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Monocrotaline; Neutrophils; Rats; Rats, Sprague-Dawley; Survival Rate | 2008 |
Molecular and electrical remodeling of L- and T-type Ca(2+) channels in rat right atrium with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Calcium Channels, L-Type; Calcium Channels, T-Type; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Heart Atria; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Monocrotaline; Patch-Clamp Techniques; Rats; Rats, Wistar; RNA, Messenger | 2009 |
Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrot
Topics: Animals; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Image Processing, Computer-Assisted; Imidazoles; Immunohistochemistry; Monocrotaline; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pulmonary Artery; Quinoxalines; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Smad3 Protein; Transforming Growth Factor beta1 | 2009 |
Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling.
Topics: Administration, Oral; Animals; Blood Pressure; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Fibrillar Collagens; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Natriuretic Peptides; Osteopontin; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Rats, Wistar; RNA, Messenger; Sildenafil Citrate; Stroke Volume; Sulfones; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Ventricular Pressure; Ventricular Remodeling | 2009 |
Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease.
Topics: Animals; Benzamides; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell Movement; Chronic Disease; Disease Models, Animal; Disease Progression; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta | 2009 |
3-Hydroxy-3-methylglutaryl (HMG)-COA reductase inhibitors and phosphodiesterase type V inhibitors attenuate right ventricular pressure and remodeling in a rat model of pulmonary hypertension.
Topics: Animals; Atorvastatin; Disease Models, Animal; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Pravastatin; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Simvastatin | 2009 |
The remodeling of connexin in the hypertrophied right ventricular in pulmonary arterial hypertension and the effect of a dual ET receptor antagonist (bosentan).
Topics: Animals; Bosentan; Connexin 43; Disease Models, Animal; Endothelin Receptor Antagonists; Gap Junctions; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microscopy, Confocal; Microscopy, Electron; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Sulfonamides; Ventricular Remodeling | 2009 |
Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Apoptosis; Collagen; Diastole; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Male; Monocrotaline; Myocardial Contraction; Myocardium; Myosin Heavy Chains; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; RNA, Messenger; Systole; Tenascin; Time Factors; Ventricular Dysfunction, Left; Ventricular Pressure | 2009 |
Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of Kv1.5 channels in rats.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Hypertension, Pulmonary; Kv1.5 Potassium Channel; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Time Factors; Up-Regulation | 2009 |
Nanoparticle-mediated delivery of nuclear factor kappaB decoy into lungs ameliorates monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Drug Delivery Systems; Humans; Hypertension, Pulmonary; Monocrotaline; Nanoparticles; NF-kappa B; Oligodeoxyribonucleotides; Rats | 2009 |
Cirrhosis ameliorates monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Common Bile Duct; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Hypertension, Pulmonary; Ligation; Liver Cirrhosis, Biliary; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasodilation | 2009 |
Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Disease Models, Animal; Hepatectomy; Hepatic Veno-Occlusive Disease; Liver Regeneration; Monocrotaline; Organoplatinum Compounds; Oxaliplatin; Rats; Rats, Sprague-Dawley | 2009 |
Pulmonary hypertension modifies responsiveness of sinoatrial cells of rat hearts to adrenomimetics and activators of ATP-sensitive K+ channels in a gender-dependent way.
Topics: Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Chromans; Disease Models, Animal; Female; Guinea Pigs; Heart Rate; Hypertension, Pulmonary; Isoproterenol; KATP Channels; Male; Monocrotaline; Pyrrolidines; Rats; Sex Factors; Sinoatrial Node; Tumor Necrosis Factor-alpha | 2009 |
The effects and mechanisms of mycophenolate mofetil on pulmonary arterial hypertension in rats.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypertrophy; Immunosuppressive Agents; Male; Monocrotaline; Muscle, Smooth, Vascular; Mycophenolic Acid; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2010 |
Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats.
Topics: Animals; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Secondary Prevention; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Time Factors | 2009 |
Opposite effects of training in rats with stable and progressive pulmonary hypertension.
Topics: Adaptation, Physiological; Animals; Biopsy; Capillaries; Cardiac Catheterization; Cardiac Output; Coronary Circulation; Disease Models, Animal; Disease Progression; Echocardiography; Heart Failure; Hypertension, Pulmonary; Male; Monocrotaline; Myocarditis; Physical Conditioning, Animal; Physical Endurance; Rats; Rats, Wistar; Rest; Survival Rate | 2009 |
Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme 2; Animals; Disease Models, Animal; Gene Transfer Techniques; Hypertension, Pulmonary; Infusions, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Peptidyl-Dipeptidase A; Probability; Random Allocation; Renin-Angiotensin System; RNA, Messenger; Sensitivity and Specificity | 2009 |
[Simvastatin prevents the development of pulmonary hypertension in the rats through reduction of inflammation].
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Hypertension, Pulmonary; Interleukin-6; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Necrosis Factor-alpha | 2009 |
Propylthiouracil attenuates monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Antihypertensive Agents; Arterioles; Caspase 3; Connexin 43; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Matrix Metalloproteinase 9; Monocrotaline; Nitric Oxide Synthase Type III; Propylthiouracil; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha; Ventricular Function, Right; Ventricular Pressure | 2009 |
Syngeneic bone marrow mononuclear cells improve pulmonary arterial hypertension through vascular endothelial growth factor upregulation.
Topics: Animals; Bone Marrow Transplantation; Cells, Cultured; Disease Models, Animal; Female; Genetic Therapy; Hypertension, Pulmonary; Immunohistochemistry; Mice; Mice, Inbred C57BL; Monocrotaline; Monocytes; Receptors, Vascular Endothelial Growth Factor; Transplantation, Isogeneic; Up-Regulation; Vascular Endothelial Growth Factors | 2009 |
Senescent endothelial progenitor cells from dogs with pulmonary arterial hypertension: a before-after self-controlled study.
Topics: Animals; Cell Culture Techniques; Cell Separation; Cells, Cultured; Cellular Senescence; Disease Models, Animal; Dogs; Endothelial Cells; Endothelium, Vascular; Flow Cytometry; Hypertension, Pulmonary; Male; Monocrotaline; Neovascularization, Physiologic; Stem Cells | 2009 |
Establishment of rat model of cardiopulmonary bypass in pulmonary hypertension.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Cardiopulmonary Bypass; Disease Models, Animal; Hematocrit; Hypertension, Pulmonary; Interleukin-6; Male; Monocrotaline; Oxygen; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha | 2009 |
Alterations in pharmacological action of the right ventricle of monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Body Weight; Cardiotonic Agents; Disease Models, Animal; Electrocardiography; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Male; Monocrotaline; Myocardial Contraction; Organ Size; Perfusion; Rats; Rats, Wistar; Ventricular Function, Right | 2009 |
Protective effects of hydroalcoholic extract from rhizomes of Cynodon dactylon (L.) Pers. on compensated right heart failure in rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Cyanosis; Cynodon; Disease Models, Animal; Dyspnea; Fatigue; Heart; Heart Failure; Lung; Male; Monocrotaline; Myocardial Contraction; Phytotherapy; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Rhizome | 2009 |
Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart.
Topics: Animals; Cardiac Pacing, Artificial; Chronic Disease; Disease Models, Animal; Heart Failure; Heart Septum; Hypertension, Pulmonary; In Vitro Techniques; Magnetic Resonance Imaging; Male; Monocrotaline; Myocardial Contraction; Perfusion; Rats; Reproducibility of Results; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Left; Ventricular Function, Right; Ventricular Pressure | 2009 |
Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.
Topics: Animals; Arterioles; Cardiac Output; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Extracellular Matrix Proteins; Female; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Lung; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Myocardial Contraction; Myocardium; Pulmonary Alveoli; Pulmonary Artery; Rats; Rats, Wistar; Recovery of Function; RNA, Messenger; Stroke Volume; Time Factors; Transplantation, Homologous; Vascular Endothelial Growth Factor A; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2009 |
Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Propanolamines; Rats; Rats, Wistar; Sympathetic Nervous System; Ventricular Pressure | 2009 |
Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats.
Topics: Animals; Blood Pressure; Blotting, Western; Cell Proliferation; Disease Models, Animal; Down-Regulation; GATA6 Transcription Factor; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Time Factors | 2009 |
Modulation of monocrotaline-induced cor pulmonale by grape juice.
Topics: Animals; Antioxidants; Beverages; Body Weight; Disease Models, Animal; Lipid Peroxidation; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Organ Size; Pulmonary Heart Disease; Rats; Rats, Wistar; Ventricular Pressure; Vitis | 2010 |
Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mesenteric Arteries; Monocrotaline; Myocardium; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2010 |
Innate immunity in the therapeutic actions of endothelial progenitor cells in pulmonary hypertension.
Topics: Animals; Biomarkers; Blood Pressure; Cell Death; Cells, Cultured; Coculture Techniques; Dendritic Cells; Disease Models, Animal; Endothelial Cells; Flow Cytometry; Humans; Hypertension, Pulmonary; Immunity, Innate; Killer Cells, Natural; Lung; Monocrotaline; Monocytes; Rats; Rats, Nude; Spleen; Stem Cells | 2010 |
Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation.
Topics: Administration, Inhalation; Animals; Cell Division; Cells, Cultured; Chronic Disease; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocrotaline; Myocytes, Smooth Muscle; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sodium Nitrite; Xanthine Dehydrogenase | 2010 |
Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure.
Topics: Animals; Antioxidants; Disease Models, Animal; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Organometallic Compounds; Rats; Rats, Wistar; Reactive Oxygen Species; Salicylates; Ventricular Dysfunction, Right; Ventricular Remodeling | 2010 |
The extracellular signal-regulated kinase is involved in the effects of sildenafil on pulmonary vascular remodeling.
Topics: Actins; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Dual Specificity Phosphatase 1; Fluorescent Antibody Technique; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocrotaline; Phosphorylation; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sildenafil Citrate; Sulfones; Vasodilator Agents | 2010 |
Pulmonary hypertension is ameliorated in mice deficient in thrombin-activatable fibrinolysis inhibitor.
Topics: Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Capillary Permeability; Carboxypeptidase B2; Chemokine CCL2; Disease Models, Animal; Fibrinolysis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocrotaline; Platelet-Derived Growth Factor; Pulmonary Artery; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Weight Loss | 2010 |
Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelial Cells; Fibroblasts; Gene Expression Profiling; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Male; MicroRNAs; Monocrotaline; Muscle, Smooth, Vascular; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Ribonuclease III; Time Factors | 2010 |
Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes.
Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy; Male; Monocrotaline; Muscle Relaxation; Myocardial Contraction; Myocytes, Cardiac; Oxygen; Papillary Muscles; Rats; Rats, Wistar | 2010 |
A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat model.
Topics: Analysis of Variance; Animals; Blood Flow Velocity; Cardiac Catheterization; Disease Models, Animal; Echocardiography, Doppler; Female; Hypertension, Pulmonary; Monocrotaline; Predictive Value of Tests; Rats; Rats, Nude; ROC Curve; Sensitivity and Specificity; Tricuspid Valve Insufficiency; Vascular Resistance | 2010 |
Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Anticholesteremic Agents; Disease Models, Animal; Drug Therapy, Combination; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Simvastatin; Sulfones | 2010 |
Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Disease Models, Animal; Histone Deacetylase Inhibitors; Hypertrophy, Right Ventricular; Ligation; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Valproic Acid | 2010 |
Analysis of responses to the Rho-kinase inhibitor Y-27632 in the pulmonary and systemic vascular bed of the rat.
Topics: Amides; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Injections, Intravenous; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; rho-Associated Kinases; Soluble Guanylyl Cyclase; Time Factors; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2010 |
Early inflammatory response during the development of right ventricular heart failure in a rat model.
Topics: Animals; Autoradiography; Disease Models, Animal; Disease Progression; Gallium Radioisotopes; Gene Expression Profiling; Heart Failure; Hypertrophy, Right Ventricular; Immunochemistry; Inflammation; Male; Monocrotaline; Myocardium; Neutrophil Activation; Peroxidase; Radionuclide Imaging; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Right | 2010 |
Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.
Topics: Animals; Antihypertensive Agents; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epoprostenol; Humans; Hypertension, Pulmonary; Iloprost; Inhibitor of Differentiation Protein 1; Male; Monocrotaline; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Phosphorylation; Promoter Regions, Genetic; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA Interference; Smad Proteins; Smad1 Protein; Smad5 Protein; Smad6 Protein; Transfection; Up-Regulation | 2010 |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Electrocardiography; Entropy; Heart Rate; Hypertension, Pulmonary; Injections, Subcutaneous; Ketamine; Monocrotaline; Rats; Rats, Wistar; Time Factors | 2010 |
Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension.
Topics: Animals; Blotting, Western; Bone Morphogenetic Protein Receptors; Disease Models, Animal; Down-Regulation; Enzyme Induction; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Smad7 Protein; Ubiquitin-Protein Ligases; Ubiquitination | 2010 |
Urotensin II receptor antagonist attenuates monocrotaline-induced cardiac hypertrophy in rats.
Topics: Animals; Atrial Function; Atrial Natriuretic Factor; Cardiotonic Agents; Cell Hypoxia; Disease Models, Animal; Humans; Hypertrophy, Right Ventricular; Infusions, Intravenous; Infusions, Subcutaneous; Male; Monocrotaline; Myocardial Contraction; Myocardium; Peptide Fragments; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; Time Factors; Urotensins; Vasoconstriction; Ventricular Function, Right | 2010 |
Systemic evaluation of platelet and leukocyte activation and interaction in a rat model of pulmonary arterial hypertension.
Topics: Animals; Cell Communication; Disease Models, Animal; Flow Cytometry; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Leukocytes; Male; Monocrotaline; Platelet Activation; Rats; Rats, Sprague-Dawley | 2010 |
Rapid quantification of myocardial fibrosis: A new macro-based automated analysis.
Topics: Aged; Animals; Automation, Laboratory; Azo Compounds; Cardiomyopathies; Coloring Agents; Disease Models, Animal; Fibrosis; Humans; Hypertension, Pulmonary; Image Interpretation, Computer-Assisted; Male; Microscopy, Polarization; Monocrotaline; Myocardium; Rats; Rats, Wistar | 2010 |
Transgenic expression of human matrix metalloproteinase-9 augments monocrotaline-induced pulmonary arterial hypertension in mice.
Topics: Actins; Animals; Antigens, Differentiation; Base Sequence; Blood Pressure; Disease Models, Animal; DNA Primers; Gene Expression; Humans; Hypertension, Pulmonary; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Monocrotaline; Recombinant Proteins; RNA, Messenger | 2011 |
Effects of simvastatin on pulmonary C-fiber sensitivity in rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Heme Oxygenase (Decyclizing); Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Nerve Fibers, Unmyelinated; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Simvastatin | 2011 |
Effects of atorvastatin and losartan on monocrotaline-induced pulmonary artery remodeling in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Atorvastatin; Base Sequence; Calcium Channels, L-Type; Disease Models, Animal; DNA Primers; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Inositol 1,4,5-Trisphosphate Receptors; Losartan; Male; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2010 |
Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats.
Topics: Animals; Cytokines; Disease Models, Animal; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fluoxetine; Hypertension, Pulmonary; Inflammation; Lung; Male; Matrix Metalloproteinase Inhibitors; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Tissue Inhibitor of Metalloproteinases | 2011 |
Oxidized low-density lipoprotein and tissue factor are involved in monocrotaline/lipopolysaccharide-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Cell Culture Techniques; Chemical and Drug Induced Liver Injury; Chemokine CXCL16; Chemokine CXCL6; Chemokines, CXC; Collagen; Data Interpretation, Statistical; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Hep G2 Cells; Humans; Lipopolysaccharides; Lipoproteins, LDL; Liver; Male; Mice; Mice, Inbred Strains; Monocrotaline; Oxidation-Reduction; Receptors, Scavenger; Thromboplastin | 2011 |
The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline.
Topics: Analysis of Variance; Animals; Catalase; Cerium; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Histocytochemistry; Liver; Male; Microscopy, Electron; Monocrotaline; Nanoparticles; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2011 |
Hepatocyte growth factor improves the survival of rats with pulmonary arterial hypertension via the amelioration of pulmonary hemodynamics.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; C-Reactive Protein; Constriction, Pathologic; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Hemodynamics; Hepatocyte Growth Factor; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Platelet-Derived Growth Factor; Pulmonary Artery; Rats; Rats, Wistar; Recombinant Proteins; Survival Analysis | 2011 |
Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels.
Topics: Animals; Aspirin; Blood Pressure; Body Weight; Disease Models, Animal; Heart Rate; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Serotonin; Survival Analysis | 2011 |
Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium Channels; Computer Simulation; Disease Models, Animal; Electric Stimulation; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Potassium Channels; Rats; Rats, Wistar; Stroke Volume; Tachycardia, Ventricular | 2011 |
Doppler flow spectra of the superior vena cava in a rat model of chronic pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Echocardiography, Doppler; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Rats; Rats, Sprague-Dawley; Systole; Vena Cava, Superior | 2011 |
Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension.
Topics: Analysis of Variance; Animals; Blood Pressure; Blotting, Western; Connexin 43; Connexins; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Fluorescent Antibody Technique; Gap Junction alpha-4 Protein; Gap Junction alpha-5 Protein; Gap Junctions; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Muscle, Smooth, Vascular; Phenylephrine; Pulmonary Artery; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Serotonin; Vasoconstriction; Vasoconstrictor Agents | 2011 |
Acceleration of Ca2+ waves in monocrotaline-induced right ventricular hypertrophy in the rat.
Topics: Animals; Arrhythmias, Cardiac; Calcium Signaling; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kinetics; Membrane Potentials; Monocrotaline; Myocardial Contraction; Myocardium; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Ventricular Function, Right; Ventricular Pressure | 2011 |
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Cell Degranulation; Cromolyn Sodium; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mast Cells; Monocrotaline; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Rats; Rats, Sprague-Dawley; Ventricular Function, Right; Ventricular Remodeling | 2011 |
Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: 4-Aminobenzoic Acid; Animals; Body Weight; Cardiomegaly; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; para-Aminobenzoates; Pulmonary Artery; Rats; Rats, Wistar; Survival Analysis | 2011 |
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Disease Models, Animal; Echocardiography, Doppler; Endothelin A Receptor Antagonists; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoxazoles; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfones; Time Factors; Ventricular Function, Right; Ventricular Remodeling | 2011 |
Transgenic expression of human matrix metalloproteinase-1 attenuates pulmonary arterial hypertension in mice.
Topics: Actins; Animals; Antigens, Differentiation; Cell Proliferation; Collagen; Disease Models, Animal; Humans; Hyperplasia; Hypertension, Pulmonary; Macrophages; Matrix Metalloproteinase 1; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Up-Regulation | 2012 |
Alteration of pulmonary artery integrin levels in chronic hypoxia and monocrotaline-induced pulmonary hypertension.
Topics: Animals; Calcium Signaling; Chronic Disease; Disease Models, Animal; Focal Adhesion Kinase 1; Hypertension, Pulmonary; Hypoxia; Integrins; Male; Monocrotaline; Muscle, Smooth, Vascular; Phosphorylation; Pulmonary Artery; Rats; Rats, Wistar | 2011 |
Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension.
Topics: Adult; Animals; Antihypertensive Agents; Apoptosis; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II; Calcium; Cell Proliferation; Cells, Cultured; Dehydroepiandrosterone; Disease Models, Animal; Enzyme Activation; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; In Situ Nick-End Labeling; Inhibitor of Apoptosis Proteins; Male; Membrane Potential, Mitochondrial; MicroRNAs; Microtubule-Associated Proteins; Middle Aged; Monocrotaline; Muscle, Smooth; Myocytes, Smooth Muscle; NFATC Transcription Factors; Proto-Oncogene Proteins c-pim-1; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Survivin; Vasodilator Agents | 2011 |
Mast cell inhibition improves pulmonary vascular remodeling in pulmonary hypertension.
Topics: Animals; Cell Proliferation; Chymases; Cromolyn Sodium; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Mast Cells; Monocrotaline; Muscle, Smooth, Vascular; Neovascularization, Pathologic; Rats; Rats, Wistar; Sulfonamides; Thiophenes | 2012 |
Evidence of diminished coronary flow in pulmonary hypertension: explaining angina pectoris in this patient group?
Topics: Angina Pectoris; Animals; Blood Flow Velocity; Blood Pressure; Cardiac Catheterization; Cardiac Output; Coronary Circulation; Dilatation, Pathologic; Disease Models, Animal; Echocardiography, Doppler; Female; Hypertension, Pulmonary; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Nude; Time Factors; Ventricular Function, Left | 2011 |
Development and characterization of an animal model of severe pulmonary arterial hypertension.
Topics: Animals; Chronic Disease; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Rats; Rats, Wistar; Tunica Media | 2012 |
Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antihypertensive Agents; Bisoprolol; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Echocardiography; Fibrosis; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Wistar; Signal Transduction; Vascular Resistance | 2012 |
Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.
Topics: Animals; Calcium; Disease Models, Animal; Excitation Contraction Coupling; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microscopy, Confocal; Monocrotaline; Myocardial Contraction; Myocytes, Cardiac; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Treatment Outcome; Ventricular Dysfunction, Right; Ventricular Remodeling | 2012 |
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.
Topics: Animals; Case-Control Studies; Caveolin 1; CD47 Antigen; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocrotaline; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Thrombospondin 1; Up-Regulation | 2012 |
Effects of autologous bone marrow mononuclear cells implantation in canine model of pulmonary hypertension.
Topics: Animals; Bone Marrow Transplantation; Cell Differentiation; Cell Separation; Cell Tracking; Disease Models, Animal; Dogs; Endothelial Cells; Endothelin-1; Flow Cytometry; Fluorescent Antibody Technique; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-6; Monocrotaline; Neovascularization, Physiologic; Pulmonary Artery; RNA, Messenger; Stem Cell Transplantation; Time Factors; Transplantation, Autologous; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Ventricular Function, Right | 2012 |
Monocrotaline-induced pulmonary hypertension in Wistar rats.
Topics: Animals; Antihypertensive Agents; Cardiac Output; Carotid Arteries; Catheterization, Swan-Ganz; Disease Models, Animal; Femoral Artery; Femoral Vein; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Wedge Pressure; Rats; Rats, Wistar | 2009 |
Cardiac and vascular atrogin-1 mRNA expression is not associated with dexamethasone efficacy in the monocrotaline model of pulmonary hypertension.
Topics: Animals; Blood Pressure; Dexamethasone; Disease Models, Animal; Drug Antagonism; Gene Expression; Glucocorticoids; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Muscle Proteins; Myostatin; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; SKP Cullin F-Box Protein Ligases | 2012 |
Effects of purple grape juice in the redox-sensitive modulation of right ventricular remodeling in a pulmonary arterial hypertension model.
Topics: Animals; Beverages; Caspase 3; Disease Models, Animal; Echocardiography; Familial Primary Pulmonary Hypertension; Hydrogen Peroxide; Hypertension, Pulmonary; Lipid Peroxidation; Male; Monocrotaline; Oxidation-Reduction; Rats; Rats, Wistar; Signal Transduction; Thioredoxins; Ventricular Remodeling; Vitis | 2012 |
Fluoxetine protects against monocrotaline-induced pulmonary arterial remodeling by inhibition of hypoxia-inducible factor-1α and vascular endothelial growth factor.
Topics: Animals; Antihypertensive Agents; Cell Proliferation; Disease Models, Animal; Fluoxetine; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vascular Endothelial Growth Factor A | 2012 |
PAR-2 inhibition reverses experimental pulmonary hypertension.
Topics: Adolescent; Adult; Animals; Antibodies, Neutralizing; Becaplermin; Benzamides; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imatinib Mesylate; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oligopeptides; Piperazines; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptor, Platelet-Derived Growth Factor beta; RNA Interference; Signal Transduction; Time Factors; Transfection; Tryptases; Young Adult | 2012 |
Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.
Topics: Aminopeptidases; Animals; Cell Proliferation; Cells, Cultured; Cyclohexanes; Disease Models, Animal; Fatty Acids, Unsaturated; Gene Expression Regulation; Glycoproteins; Heart Ventricles; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Myocytes, Cardiac; Myocytes, Smooth Muscle; Myofibroblasts; Platelet-Derived Growth Factor; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2012 |
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Case-Control Studies; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Cobalt; Cyclin B1; Disease Models, Animal; Dynamins; Enzyme Activation; Familial Primary Pulmonary Hypertension; Genetic Therapy; Glycolysis; GTP Phosphohydrolases; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microtubule-Associated Proteins; Mitochondria, Muscle; Mitochondrial Proteins; Mitosis; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pulmonary Artery; Quinazolinones; Rats; Rats, Sprague-Dawley; RNA Interference; Serine; Time Factors; Transfection | 2012 |
Role of Src tyrosine kinases in experimental pulmonary hypertension.
Topics: Animals; Apoptosis; Becaplermin; Benzamides; Cell Proliferation; Cells, Cultured; Chemotaxis; Dasatinib; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Imatinib Mesylate; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Pyrimidines; Rats; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Thiazoles; Time Factors | 2012 |
Beneficial effects of γ-aminobutyric acid on right ventricular pressure and pulmonary vascular remodeling in experimental pulmonary hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelin-1; gamma-Aminobutyric Acid; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Norepinephrine; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Ventricular Pressure | 2012 |
Erythropoietin, but not asialoerythropoietin or carbamyl-erythropoietin, attenuates monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Asialoglycoproteins; Disease Models, Animal; Erythropoietin; Hypertension, Pulmonary; Male; Monocrotaline; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Erythropoietin; RNA, Messenger; Treatment Outcome | 2012 |
Attenuation of monocrotaline-induced pulmonary arterial hypertension in rats by rosuvastatin.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Familial Primary Pulmonary Hypertension; Fluorobenzenes; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide Synthase Type III; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Pyrimidines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Time Factors | 2012 |
Differential calcium handling in two canine models of right ventricular pressure overload.
Topics: Animals; Calcium; Calcium-Binding Proteins; Disease Models, Animal; Dogs; Heart Ventricles; Monocrotaline; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Ventricular Dysfunction, Right; Ventricular Pressure | 2012 |
Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model.
Topics: Animals; Benzenesulfonamides; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Sulfonamides; Ventricular Pressure | 2012 |
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
Topics: Aniline Compounds; Animals; Calcimimetic Agents; Calcium Signaling; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthalenes; Phenethylamines; Propylamines; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; RNA Interference; Spermine; Time Factors; Transfection; Vasoconstriction | 2012 |
Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9.
Topics: Animals; Disease Models, Animal; Down-Regulation; Hepatectomy; Hepatic Veno-Occlusive Disease; Liver; Male; MAP Kinase Kinase 4; Matrix Metalloproteinase 9; Monocrotaline; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sorafenib | 2012 |
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.
Topics: Animals; Benzamides; Benzimidazoles; Case-Control Studies; Crk-Associated Substrate Protein; Disease Models, Animal; Endothelial Cells; Epidermal Growth Factor; Familial Primary Pulmonary Hypertension; Fibroblast Growth Factor 2; Gefitinib; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Mice; Monocrotaline; Myocytes, Smooth Muscle; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pulmonary Artery; Pyrimidines; Quinazolines; Quinolones; Rats; Signal Transduction | 2012 |
Longitudinal in vivo SPECT/CT imaging reveals morphological changes and cardiopulmonary apoptosis in a rodent model of pulmonary arterial hypertension.
Topics: Animals; Annexins; Apoptosis; Blood Pressure; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Heart Ventricles; Humans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocardium; Perfusion; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Systole; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Ventricular Remodeling | 2012 |
Monocrotaline-induced pulmonary arterial hypertension is attenuated by TNF-α antagonists via the suppression of TNF-α expression and NF-κB pathway in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Disease Models, Animal; Etanercept; Familial Primary Pulmonary Hypertension; Gene Expression Regulation; Hypertension, Pulmonary; Immunoglobulin G; Inflammation; Lung; Male; Monocrotaline; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2013 |
[Pathophysiological characteristics of rat pulmonary hypertension and cor pulmonale induced by monocrotaline].
Topics: Animals; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide; Pulmonary Heart Disease; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2012 |
Caveolin-1 expression during the progression of pulmonary hypertension.
Topics: Animals; Caveolin 1; Disease Models, Animal; Endothelial Cells; Gene Expression Profiling; Hypertension, Pulmonary; Lung; Male; Matrix Metalloproteinase 2; Monocrotaline; Myocardium; Rats; Rats, Sprague-Dawley | 2012 |
Assessment of the endothelial functions in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Aorta, Thoracic; Arginine; Disease Models, Animal; Endothelium, Vascular; Hydrogen Sulfide; Hypertension, Pulmonary; Iloprost; Male; Monocrotaline; Nitric Oxide; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2013 |
Additive effect of tadalafil and simvastatin on monocrotaline-induced pulmonary hypertension rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Arterioles; Carbolines; Disease Models, Animal; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Simvastatin; Tadalafil; Time Factors; Vasodilator Agents | 2012 |
BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cell Proliferation; Disease Models, Animal; DNA; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Indoles; Ligands; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Monocrotaline; Myocytes, Smooth Muscle; Protein Binding; Pyrroles; Rats; Receptor, trkB; Signal Transduction | 2012 |
Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Binding Sites; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell Proliferation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Disease Models, Animal; Dose-Response Relationship, Drug; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Inhibitor of Differentiation Protein 1; Male; Monocrotaline; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Phosphodiesterase 5 Inhibitors; Phosphorylation; Piperazines; Promoter Regions, Genetic; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Sildenafil Citrate; Smad1 Protein; Smad5 Protein; Sulfones; Transfection; Vasodilator Agents | 2013 |
Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA-Rho kinase and Akt signalling pathways in rats.
Topics: Airway Remodeling; Animals; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Fluoxetine; Hypertension, Pulmonary; Isoenzymes; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Selective Serotonin Reuptake Inhibitors | 2012 |
Improvement of exercise capacity in monocrotaline-induced pulmonary hypertension by the phosphodiesterase-5 inhibitor Vardenafil.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Imidazoles; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Physical Conditioning, Animal; Piperazines; Rats; Rats, Wistar; Sulfones; Triazines; Vardenafil Dihydrochloride | 2013 |
L-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure.
Topics: Angiotensin II; Animals; Apoptosis; Carnitine; Caspase 3; Caspase 9; Caspases; Cell Nucleus; Cells, Cultured; Cytoprotection; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Glucose Transporter Type 4; Heart Failure; In Situ Nick-End Labeling; Liver Function Tests; Male; Monocrotaline; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Muscular Disorders, Atrophic; Myosin Heavy Chains; Protein Isoforms; Rats; Rats, Sprague-Dawley; Sphingolipids; Staurosporine; Tumor Necrosis Factor-alpha | 2002 |
Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium.
Topics: Animals; Calibration; Cardiomegaly; Disease Models, Animal; Histocytochemistry; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Male; Monocrotaline; Myocardium; Myocytes, Cardiac; Myoglobin; Oxygen Consumption; Rats; Rats, Wistar; Succinate Dehydrogenase; Time Factors; Transcription Factors | 2002 |
Heme oxygenase-1 reduces murine monocrotaline-induced pulmonary inflammatory responses and resultant right ventricular overload.
Topics: Animals; Body Weight; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypertension, Pulmonary; Inflammation; Lung; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Monocrotaline; Myocytes, Cardiac; Rats; Stress, Mechanical; Ventricular Function, Right | 2002 |
Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.
Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Disease Models, Animal; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Organ Size; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Simvastatin; Treatment Outcome; Tunica Intima | 2002 |
Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure.
Topics: Animals; Binding, Competitive; Cell Membrane; Disease Models, Animal; Eye Proteins; Fluoxetine; G-Protein-Coupled Receptor Kinase 1; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Size; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Neurotransmitter; Rhodopsin; Symporters | 2002 |
Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome.
Topics: Animals; Cell Size; Disease Models, Animal; Endothelium; Erythrocytes; Glutathione; Liver Diseases; Male; Microcirculation; Monocrotaline; Perfusion; Phagocytosis; Rats; Rats, Sprague-Dawley; Syndrome | 2003 |
Skeletal muscle abnormalities in rats with experimentally induced heart hypertrophy and failure.
Topics: Animals; Disease Models, Animal; Heart Failure; Hypertrophy, Right Ventricular; Monocrotaline; Muscle, Skeletal; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley | 2003 |
Activation of the right ventricular endothelin (ET) system in the monocrotaline model of pulmonary hypertension: response to chronic ETA receptor blockade.
Topics: Animals; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Endothelins; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Phenylpropionates; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A | 2003 |
Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells.
Topics: Adrenomedullin; Animals; Cells, Cultured; Disease Models, Animal; DNA; Drug Carriers; Endothelium, Vascular; Fetal Blood; Gelatin; Gene Transfer Techniques; Genetic Therapy; Green Fluorescent Proteins; Humans; Hybrid Cells; Hypertension, Pulmonary; Luminescent Proteins; Male; Monocrotaline; Peptides; Phagocytosis; Pulmonary Circulation; Rats; Rats, Nude; Stem Cell Transplantation; Stem Cells; Survival Rate; Vascular Resistance | 2003 |
Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat.
Topics: Actin Cytoskeleton; Adrenergic beta-Agonists; Animals; Biomechanical Phenomena; Body Weight; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Isoproterenol; Male; Monocrotaline; Myocardial Contraction; Norepinephrine; Organ Size; Rats; Rats, Wistar; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Stress, Mechanical | 2003 |
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats.
Topics: Administration, Oral; Animals; Biopsy, Needle; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Hemodynamics; Hypertension, Pulmonary; Immunohistochemistry; Male; Monocrotaline; Phosphodiesterase Inhibitors; Piperazines; Probability; Pulmonary Heart Disease; Purines; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sildenafil Citrate; Sulfones; Survival Rate; Time Factors | 2004 |
Progressive development of pulmonary hypertension leading to right ventricular hypertrophy assessed by echocardiography in rats.
Topics: Animals; Disease Models, Animal; Disease Progression; Echocardiography; Echocardiography, Doppler, Pulsed; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar | 2003 |
Effect of nolomirole on monocrotaline-induced heart failure.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Aldosterone; Animals; Ascitic Fluid; Atrial Natriuretic Factor; Body Weight; Disease Models, Animal; Dopamine Agonists; Drug Evaluation, Preclinical; Esters; Female; Heart Atria; Heart Failure; Heart Ventricles; Hypertrophy, Right Ventricular; Indoles; Monocrotaline; Norepinephrine; Pleural Effusion; Rats; Rats, Sprague-Dawley; Tetrahydronaphthalenes | 2004 |
[Involvement of tetrahydrobiopterin in local change of endothelium-dependent vasorelaxation in pulmonary hypertension].
Topics: Animals; Biopterins; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide Synthase; Oxygen; Pulmonary Artery; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |
Emission-particle-induced ventilatory abnormalities in a rat model of pulmonary hypertension.
Topics: Animals; Carbon; Coal Ash; Disease Models, Animal; Hypertension, Pulmonary; Inflammation; Inhalation Exposure; Lung; Male; Monocrotaline; Particle Size; Particulate Matter; Rats; Rats, Sprague-Dawley; Respiratory Function Tests | 2004 |
Antioxidant and oxidative stress changes in experimental cor pulmonale.
Topics: Animals; Antioxidants; Cardiomegaly; Catalase; Disease Models, Animal; Glutathione Peroxidase; Heart Ventricles; Lipid Peroxidation; Liver; Lung; Male; Monocrotaline; Organ Size; Oxidative Stress; Pulmonary Heart Disease; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Time Factors; Ventricular Pressure | 2004 |
Disruption of endothelial-cell caveolin-1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Caveolin 1; Caveolins; Disease Models, Animal; DNA-Binding Proteins; Endothelial Cells; Endothelium, Vascular; Heat-Shock Proteins; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isomerases; Male; Membrane Microdomains; Mitosis; Monocrotaline; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Proliferating Cell Nuclear Antigen; Protein Disulfide-Isomerases; Protein Processing, Post-Translational; Pulmonary Artery; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Trans-Activators; von Willebrand Factor | 2004 |
Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cyclic AMP; Cytochrome P-450 Enzyme System; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Intramolecular Oxidoreductases; Lung; Monocrotaline; Muscle, Skeletal; Plasmids; Prognosis; Pulmonary Artery; Rats; Survival Rate; Time Factors | 2004 |
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Isoenzymes; Lung; Male; Monocrotaline; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2005 |
[Decrease of nitric oxide (NO)-cGMP-dependent vasodilatation in the vessels of lesser circulation in endothelial dysfunction].
Topics: Animals; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Guanidines; Hypertension, Pulmonary; Lung; Monocrotaline; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Pulmonary Circulation; Rats; Rats, Wistar; Vasodilation | 2005 |
YM598, an orally active ET(A) receptor antagonist, ameliorates the progression of cardiopulmonary changes and both-side heart failure in rats with cor pulmonale and myocardial infarction.
Topics: Administration, Oral; Animals; Cardiovascular Agents; Coronary Vessels; Disease Models, Animal; Disease Progression; Endothelin A Receptor Antagonists; Heart Failure; Hemodynamics; Hypertension, Pulmonary; Ligation; Male; Monocrotaline; Myocardial Infarction; Pulmonary Heart Disease; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Sulfonamides | 2004 |
Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension.
Topics: Administration, Inhalation; Animals; Disease Models, Animal; Hypertension, Pulmonary; Iloprost; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Vasodilator Agents; Ventricular Pressure | 2005 |
Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension.
Topics: Animals; Animals, Genetically Modified; Arterial Occlusive Diseases; Cell Proliferation; Disease Models, Animal; Hypertension; Hypertrophy, Right Ventricular; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Receptor, Endothelin B; Tunica Intima | 2005 |
The role of increased pulmonary blood flow in pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Atria; Heart Bypass, Right; Heart Valves; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Ultrasonography | 2005 |
Upregulation of profilin, cofilin-2 and LIMK2 in cultured pulmonary artery smooth muscle cells and in pulmonary arteries of monocrotaline-treated rats.
Topics: Animals; Cells, Cultured; Cofilin 2; Disease Models, Animal; Dogs; Hyperplasia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Lim Kinases; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Profilins; Protein Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha; Up-Regulation | 2006 |
Reduced inotropic effect of nifekalant in failing hearts in rats.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Cardiotonic Agents; Disease Models, Animal; Heart Failure; Monocrotaline; Myocardial Contraction; Pyrimidinones; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum | 2006 |
Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats.
Topics: Animals; Bosentan; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfonamides; Sulfones | 2006 |
Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension.
Topics: Adenoviridae; Animals; Cells, Cultured; Disease Models, Animal; DNA, Complementary; Femoral Vein; Genetic Therapy; Genetic Vectors; Humans; Hypertension, Pulmonary; Injections, Intravenous; Male; Mesenchymal Stem Cell Transplantation; Monocrotaline; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right | 2006 |
Short-term administration of a cell-permeable caveolin-1 peptide prevents the development of monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
Topics: Amino Acid Sequence; Animals; Biotinylation; Caveolin 1; Cell Membrane Permeability; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Molecular Sequence Data; Monocrotaline; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2006 |
Myocyte morphological characteristics differ between the phases of pulmonary hypertension-induced ventricular hypertrophy and failure.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Disease Progression; Heart Failure; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Cells; Myocardium; Prognosis; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Ventricular Pressure; Ventricular Remodeling | 2006 |
Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction.
Topics: Acetylcholine; Animals; Blood Pressure; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Paracrine Communication; Phenotype; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Time Factors; Trachea; Vascular Resistance; Vasodilation; Vasodilator Agents | 2007 |
Sequence of echocardiographic changes during development of right ventricular failure in rat.
Topics: Animals; Disease Models, Animal; Disease Progression; Heart Failure; Male; Monocrotaline; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Ultrasonography; Ventricular Dysfunction, Right | 2006 |
Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension.
Topics: Animals; Antigens, Differentiation; Cell Adhesion Molecules; Dendritic Cells; Disease Models, Animal; Humans; Hypertension, Pulmonary; Immunoenzyme Techniques; Lectins, C-Type; Lung; Male; Microscopy, Fluorescence; Monocrotaline; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Receptors, Cell Surface | 2007 |
Granulocyte colony-stimulating factor prevents progression of monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Echocardiography; Endothelium, Vascular; Granulocyte Colony-Stimulating Factor; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Inbred F344 | 2007 |
Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.
Topics: Acetylcholine; Animals; Biological Factors; Catalase; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microcirculation; Microscopy, Video; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2007 |
Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation.
Topics: Animals; Animals, Genetically Modified; Arterioles; Bone Marrow Cells; Bone Marrow Transplantation; Capillaries; Cell Differentiation; Disease Models, Animal; Femoral Artery; Green Fluorescent Proteins; Hypertension, Pulmonary; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Pulmonary Embolism; Rats; Rats, Sprague-Dawley; Thrombosis; Tunica Intima; Ventricular Dysfunction, Right | 2007 |
Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Disease Models, Animal; Female; Green Fluorescent Proteins; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocrotaline; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Artery; Stem Cell Transplantation; Stem Cells; Time Factors; Ventricular Function, Right; Ventricular Pressure | 2007 |
Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Apoptosis; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Disease Models, Animal; Disease Progression; Down-Regulation; Hypertension, Pulmonary; Immunoblotting; Immunohistochemistry; Male; Monocrotaline; Polymerase Chain Reaction; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA; Signal Transduction; Smad4 Protein; Smad5 Protein; Smad6 Protein; Smad8 Protein | 2007 |
Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Animals, Genetically Modified; Antimitotic Agents; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dipeptidyl Peptidase 4; Disease Models, Animal; Female; Hepatectomy; Hepatocytes; Liver; Liver Diseases; Liver Regeneration; Male; Monocrotaline; Rats; Rats, Inbred F344; Stem Cells; Time Factors; X Chromosome; Y Chromosome | 2007 |
The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension.
Topics: Animals; Apoptosis; Disease Models, Animal; Hypertension, Pulmonary; Lung; Models, Biological; Monocrotaline; Mutation; Pulmonary Artery; Rats; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2007 |
Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography.
Topics: Action Potentials; Animals; Body Surface Potential Mapping; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardial Contraction; Rats; Rats, Wistar; Severity of Illness Index; Systole; Time Factors; Ultrasonography; Ventricular Function, Right; Ventricular Pressure | 2007 |
Effects on cytokines and histology by treatment with the ACE inhibitor captopril and the antioxidant retinoic acid in the monocrotaline model of experimentally induced lung fibrosis.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Captopril; Cytokines; Disease Models, Animal; Male; Monocrotaline; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Tretinoin | 2007 |
Amlodipine prevents monocrotaline-induced pulmonary arterial hypertension and prolongs survival in rats independent of blood pressure lowering.
Topics: Amlodipine; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Blotting, Western; Cell Proliferation; Cytokines; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; Matrix Metalloproteinase 2; Monocrotaline; Nitric Oxide Synthase Type III; P-Selectin; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2007 |
Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension.
Topics: Angiography; Animals; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Thromboplastin; Vascular Endothelial Growth Factor Receptor-2; von Willebrand Factor | 2007 |
Comparison of lung proteome profiles in two rodent models of pulmonary arterial hypertension.
Topics: Animals; Chronic Disease; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Hypertension; Hypoxia; Lung; Male; Monocrotaline; Neoplasm Proteins; Phosphorylation; Proteome; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2007 |
Rodent models of PAH: are we there yet?
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Pneumonectomy; Pulmonary Artery; Radiography; Rats; Thromboplastin; Vascular Endothelial Growth Factor Receptor-2 | 2007 |
Oral sildenafil prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Lung Diseases, Interstitial; Male; Monocrotaline; Piperazines; Pulmonary Artery; Pulmonary Emphysema; Purines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sildenafil Citrate; Sulfones; Time Factors; Vasodilator Agents | 2007 |
Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Epoprostenol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Protein Kinase Inhibitors; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2007 |
Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension.
Topics: Animals; Cardiac Output; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Signal Transduction | 2007 |
Carnitine-mediated improved response to erythropoietin involves induction of haem oxygenase-1: studies in humans and in an animal model.
Topics: Animals; Apoptosis; Carnitine; Disease Models, Animal; Erythropoiesis; Erythropoietin; Heart Failure; Hematocrit; Heme Oxygenase-1; Hemoglobins; Humans; Leukocytes, Mononuclear; Male; Monocrotaline; Muscle, Skeletal; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Renal Dialysis; Signal Transduction | 2008 |
Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats.
Topics: Adenoviridae; Animals; beta-Galactosidase; Blood Pressure; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Heart Rate; Hypertension, Pulmonary; Lung; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2008 |
Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats.
Topics: Animals; Antihypertensive Agents; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Epoprostenol; Extracellular Signal-Regulated MAP Kinases; Hemodynamics; Hypertension, Pulmonary; Injections, Subcutaneous; Male; Microspheres; Monocrotaline; Pyridines; Rats; Rats, Wistar; Thromboxane-A Synthase | 2008 |
Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.
Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthyridines; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rats | 2008 |
Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Disease Models, Animal; Female; Green Fluorescent Proteins; Heart; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocardium; Rats; Stem Cells; Wound Healing | 2008 |
Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Hepatocytes; Hypertension, Pulmonary; Male; Monocrotaline; Plant Extracts; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured | 2008 |
Evaluation of olmesartan medoxomil in the rat monocrotaline model of pulmonary hypertension.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imidazoles; Lung; Male; Monocrotaline; Olmesartan Medoxomil; Pulmonary Artery; Rats; Rats, Wistar; Tetrazoles; Time Factors | 2008 |
Smad signaling in the rat model of monocrotaline pulmonary hypertension.
Topics: Activin Receptors; Animals; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Injections, Intraperitoneal; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad1 Protein; Smad2 Protein; Smad4 Protein; Transforming Growth Factor beta | 2008 |
Cilostazol therapy attenuates monocrotaline-induced pulmonary arterial hypertension in rat model.
Topics: Animals; Blood Pressure; Body Weight; Cilostazol; Connexin 43; Disease Models, Animal; Endothelium, Vascular; Gene Expression; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasodilator Agents | 2008 |
Effect of methylprednisolone on experimental noncardiogenic pulmonary edema.
Topics: Animals; Disease Models, Animal; Dogs; Hemodynamics; Methylprednisolone; Monocrotaline; Plants, Toxic; Pulmonary Circulation; Pulmonary Edema; Pyrrolizidine Alkaloids; Senecio | 1981 |
[Effects of prostaglandin E1 (PGE1) on pulmonary hypertension and lung vascular remodeling in a rat monocrotaline model of human pulmonary hypertension].
Topics: Alprostadil; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1995 |
Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension.
Topics: Adrenomedullin; Animals; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Immunoblotting; Lung; Male; Monocrotaline; Myocardium; Peptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reference Values; RNA; RNA, Messenger; Ventricular Function, Right | 1995 |
Establishment of canine pulmonary hypertension with dehydromonocrotaline. Importance of larger animal model for lung transplantation.
Topics: Animals; Disease Models, Animal; Dogs; Hemodynamics; Hypertension, Pulmonary; Lung Transplantation; Monocrotaline; Pulmonary Artery; Rats | 1995 |
A dehydromonocrotaline-induced pulmonary hypertension model in the beagle.
Topics: Animals; Disease Models, Animal; Dogs; Hypertension, Pulmonary; Monocrotaline | 1995 |
Sandostatin inhibits development of medial proliferation of pulmonary arteries in a rat model of pulmonary hypertension.
Topics: Animals; Cell Division; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Octreotide; Pulmonary Artery; Rats; Rats, Wistar | 1995 |
Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline.
Topics: Animals; Blood Pressure; Disease Models, Animal; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Interleukin; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins | 1994 |
[Role of serotonin in the progression of pulmonary hypertension].
Topics: Animals; Blood Platelets; Disease Models, Animal; Hypertension, Pulmonary; In Vitro Techniques; Lung; Male; Monocrotaline; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Triazines; Vasoconstriction | 1994 |
Pathology of pulmonary hypertension: a human and experimental study.
Topics: Adult; Animals; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Japan; Male; Microscopy, Electron; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 1994 |
The effect of nifedipine on monocrotaline-induced pulmonary hypertension in rats.
Topics: Acute Disease; Animals; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Injections, Intraperitoneal; Monocrotaline; Nifedipine; Organ Size; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley | 1993 |
Cardiac atrial natriuretic peptide in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Disease Models, Animal; Heart Atria; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Induction of right ventricular hypertrophy in neonatal guinea pigs by monocrotaline.
Topics: Animals; Disease Models, Animal; Guinea Pigs; Humans; Hypertrophy, Right Ventricular; Monocrotaline; Poisons | 1996 |
Microsurgery in a rat lung transplant model: analysis of benefit.
Topics: Animals; Cardiac Output; Cost-Benefit Analysis; Disease Models, Animal; Graft Rejection; Heart Rate; Hypertension, Pulmonary; Lung Transplantation; Male; Microsurgery; Monocrotaline; Pulmonary Circulation; Rats; Rats, Wistar; Vascular Resistance | 1996 |
Skeletal muscle metabolism in experimental heart failure.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Disease Models, Animal; Female; Heart Failure; Monocrotaline; Muscle, Skeletal; NAD; Organ Size; Oxidation-Reduction; Phosphocreatine; Rats; Rats, Sprague-Dawley | 1996 |
A selective type V phosphodiesterase inhibitor, E4021, protects the development of right ventricular overload and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Organ Size; Phosphodiesterase Inhibitors; Piperidines; Pulmonary Artery; Quinazolines; Rats; Rats, Wistar | 1996 |
Pulmonary hemodynamics and blood flow characteristics in chronic pulmonary hypertension.
Topics: Animals; Blood Flow Velocity; Chronic Disease; Disease Models, Animal; Dogs; Fourier Analysis; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Circulation; Pulmonary Wedge Pressure; Signal Processing, Computer-Assisted; Ultrasonography; Vascular Resistance | 1997 |
Nitric oxide improves pulmonary vascular impedance, transpulmonary efficiency, and left ventricular filling in chronic pulmonary hypertension.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dogs; Fourier Analysis; Hemodynamics; Hypertension, Pulmonary; Lung; Monocrotaline; Nitric Acid; Pulmonary Artery; Regional Blood Flow; Ventricular Function, Left | 1997 |
Single lung transplantation for canine pulmonary hypertension.
Topics: Animals; Cardiopulmonary Bypass; Disease Models, Animal; Dogs; Hemodynamics; Hypertension, Pulmonary; Lung Transplantation; Monocrotaline; Organ Size; Pulmonary Circulation; Reproducibility of Results | 1997 |
An adult canine model of chronic pulmonary hypertension for cardiopulmonary transplantation.
Topics: Age Factors; Animals; Catheterization, Swan-Ganz; Chronic Disease; Disease Models, Animal; Dogs; Heart-Lung Transplantation; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Reproducibility of Results; Ventricular Function | 1997 |
Hemodynamic and inotropic effects of nitric oxide in pulmonary hypertension.
Topics: Animals; Body Weight; Disease Models, Animal; Dogs; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Myocardial Contraction; Nitric Oxide; Pulmonary Circulation; Regional Blood Flow; Vascular Resistance | 1997 |
Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension.
Topics: Actins; Animals; Disease Models, Animal; Hemodynamics; Hyperplasia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Tunica Intima | 1997 |
Pulmonary vascular impedance and recipient chronic pulmonary hypertension following cardiac transplantation.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dogs; Electric Impedance; Fourier Analysis; Heart Transplantation; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Poisons; Prospective Studies; Pulmonary Artery | 1997 |
Cardiac and vascular responses after monocrotaline-induced hypertrophy in rats.
Topics: Animals; Body Weight; Disease Models, Animal; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardial Contraction; Poisons; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Stimulation, Chemical; Vasoconstriction | 1998 |
Thromboxane inhibition and monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Bridged Bicyclo Compounds; Disease Models, Animal; Eicosanoids; Fatty Acids, Monounsaturated; Hypertension, Pulmonary; Male; Methacrylates; Monocrotaline; Prostaglandin Antagonists; Rats; Rats, Wistar; Reference Values; Thromboxane A2; Thromboxane-A Synthase | 1997 |
Type V phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Immunohistochemistry; Male; Monocrotaline; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Pulmonary Artery; Quinazolines; Rats; Rats, Wistar; Receptors, Endothelin | 1998 |
MCAF/MCP-1 protein expression in a rat model for pulmonary hypertension induced by monocrotaline.
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Hypertension, Pulmonary; Macrophages, Alveolar; Male; Monocrotaline; Rats; Rats, Sprague-Dawley | 1998 |
Angiotensin-converting enzyme inhibition delays pulmonary vascular neointimal formation.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Northern; Cell Division; Disease Models, Animal; Elastic Tissue; Feasibility Studies; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; In Situ Hybridization; Male; Monocrotaline; Organ Size; Pneumonectomy; Poisons; Procollagen; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Tropoelastin; Tunica Intima; Tunica Media | 1998 |
Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats.
Topics: Air Pollutants; Air Pollution, Indoor; Animals; Body Temperature; Cardiovascular System; Disease Models, Animal; Heart Rate; Hypertension, Pulmonary; Leukocyte Count; Lung; Monocrotaline; Particle Size; Rats; Reproducibility of Results | 1998 |
Suppressive effect of prostaglandin E1 on pulmonary hypertension induced by monocrotaline in rats.
Topics: Alprostadil; Animals; Calcium; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Septum; Heart Ventricles; Hypertension, Pulmonary; Macrophages, Alveolar; Male; Monocrotaline; Pulmonary Wedge Pressure; Rats; Rats, Sprague-Dawley | 1999 |
Manipulation of injury and repair of the alveolar epithelium using two pneumotoxicants: 3-methylindole and monocrotaline.
Topics: Animals; Bromodeoxyuridine; Carcinogens; Cell Division; Disease Models, Animal; Epithelial Cells; Immunohistochemistry; Microscopy, Electron; Monocrotaline; Pulmonary Alveoli; Pulmonary Fibrosis; Rats; Rats, Inbred F344; Skatole | 1999 |
Characterization of a reproducible rat model of hepatic veno-occlusive disease.
Topics: Animals; Disease Models, Animal; Endothelium; Hemorrhage; Hepatic Veno-Occlusive Disease; Inflammation; Liver; Liver Cirrhosis, Experimental; Male; Monocrotaline; Necrosis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Time Factors | 1999 |
Lung injury from intratracheal and inhalation exposures to residual oil fly ash in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: Administration, Inhalation; Air Pollutants; Animals; Bronchoalveolar Lavage Fluid; Carbon; Coal Ash; Cytokines; Disease Models, Animal; DNA, Complementary; Hypertension, Pulmonary; Intubation, Intratracheal; Lung; Lung Diseases; Male; Monocrotaline; Particulate Matter; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Survival Rate | 1999 |
Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Isoxazoles; Male; Monocrotaline; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Thiophenes; Vasoconstriction; Weight Gain | 2000 |
Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pancreatic Elastase; Protease Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2000 |
Effects of concentrated ambient particles in rats and hamsters: an exploratory study.
Topics: Age Factors; Air Pollutants; Air Pollution; Animals; Blood Cell Count; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart Rate; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Maximum Allowable Concentration; Mesocricetus; Monocrotaline; Mortality; Particle Size; Rats; Rats, Inbred F344; Time Factors | 2000 |
Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Humans; Hypertension, Pulmonary; Immunohistochemistry; Intramolecular Oxidoreductases; Liposomes; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Respirovirus; Survival Analysis | 2000 |
Enhanced expression and activity of xanthine oxidoreductase in the failing heart.
Topics: Animals; Coronary Vessels; Disease Models, Animal; Disease Progression; Enzyme Induction; Female; Free Radicals; Heart Failure; Heart Ventricles; Hypertrophy, Right Ventricular; Ligation; Monocrotaline; Muscle Proteins; Myocardial Infarction; Organ Size; Rats; Rats, Sprague-Dawley; Xanthine Oxidase | 2000 |
Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Diterpenes; Drug Evaluation, Preclinical; Epoxy Compounds; Hemodynamics; Hypertension, Pulmonary; Immunosuppressive Agents; Male; Monocrotaline; Neovascularization, Pathologic; Phenanthrenes; Pneumonectomy; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Time Factors; Tunica Intima | 2000 |
The cardiac beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in monocrotaline-treated rats.
Topics: Adenylyl Cyclases; Animals; Blood Pressure; Blotting, Western; Body Weight; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; GTP-Binding Proteins; Humans; Kinetics; Male; Monocrotaline; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Muscarinic; Time Factors | 2000 |
40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats.
Topics: Animals; Cell Division; Disease Models, Animal; Everolimus; Fibromuscular Dysplasia; Hemodynamics; Hypertension, Pulmonary; Immunosuppressive Agents; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Sirolimus; Tunica Intima | 2001 |
Enhanced gene expression of renin-angiotensin system, TGF-beta1, endothelin-1 and nitric oxide synthase in right-ventricular hypertrophy.
Topics: Animals; Disease Models, Animal; Endothelin-1; Gene Expression; Hypertrophy, Right Ventricular; Male; Monocrotaline; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dietary Fats; Disease Models, Animal; Enalapril; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; In Vitro Techniques; Lung; Magnetic Resonance Imaging; Male; Monocrotaline; Nitrates; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Perfusion; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction | 2001 |
Accentuation of ANP secretion to endothelin-1 in hypertrophied atria.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Extracellular Space; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Statistics as Topic; Stress, Mechanical; Time Factors | 2001 |
Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension.
Topics: Animals; Cell Transplantation; Cells, Cultured; Disease Models, Animal; Endothelial Growth Factors; Fluorescent Dyes; Gene Transfer Techniques; Genetic Therapy; Hypertension, Pulmonary; Lung; Lymphokines; Microcirculation; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Circulation; Rats; Rats, Inbred F344; Transplantation, Isogeneic; Treatment Outcome; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Suppressive effect of pulmonary hypertension and leukocyte activation by inhaled prostaglandin E1 in rats with monocrotaline-induced pulmonary hypertension.
Topics: Administration, Inhalation; Alprostadil; Animals; Disease Models, Animal; Drug Administration Schedule; Hypertension, Pulmonary; L-Selectin; Leukocytes; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2002 |
Biochemical and structural remodeling of collagen in the right ventricular hypertrophy induced by monocrotaline.
Topics: Animals; Blood Pressure; Cardiomegaly; Collagen; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Heart Ventricles; Male; Microscopy, Electron, Scanning; Monocrotaline; Myocardium; Rats; Rats, Inbred Strains | 1992 |
The rat is a poor animal model for the study of human pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Pulmonary Artery; Pulmonary Circulation; Rats | 1992 |
A canine model for hepatic venoocclusive disease.
Topics: Animals; Bone Marrow Transplantation; Busulfan; Disease Models, Animal; Dogs; Hepatic Veno-Occlusive Disease; Liver; Monocrotaline | 1992 |
Pulmonary peptides, norepinephrine and endocrine cells in monocrotaline pulmonary hypertension.
Topics: Animals; Bombesin; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; Monocrotaline; Neuropeptides; Neurosecretory Systems; Neurotensin; Norepinephrine; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Ubiquitin Thiolesterase | 1991 |
Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Hypertension, Pulmonary; Indomethacin; Isosorbide Dinitrate; Lung; Male; Monocrotaline; Pancreatic Elastase; Plants, Toxic; Prednisolone; Pulmonary Circulation; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio | 1989 |
[Effects of various doses of monocrotaline administration on the development of pulmonary hypertension and its regression in rats].
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Systole | 1989 |
Isoproterenol sensitivity of isolated cardiac myocytes from rats with monocrotaline-induced right-sided hypertrophy and heart failure.
Topics: Animals; Calcium-Transporting ATPases; Cardiomegaly; Catecholamines; Cells, Cultured; Disease Models, Animal; Drug Tolerance; Heart; Heart Failure; Heart Ventricles; Isoproterenol; Male; Monocrotaline; Myocardial Contraction; Myocardium; Myosins; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1989 |
Echocardiographic detection of pulmonary hypertension in anesthetized rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Echocardiography; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1988 |
Induction of hepatic veno-occlusive disease in dogs.
Topics: Animals; Busulfan; Buthionine Sulfoximine; Cyclophosphamide; Disease Models, Animal; Dog Diseases; Dogs; Hepatic Veno-Occlusive Disease; Liver; Melphalan; Methionine Sulfoximine; Methotrexate; Monocrotaline; Pyrrolizidine Alkaloids; Radiation Injuries, Experimental; Radiography | 1987 |
The effect of immunosuppressants and adoptive transfer in monocrotaline pyrrole pneumotoxicity.
Topics: Animals; Antilymphocyte Serum; Body Weight; Bronchoalveolar Lavage Fluid; Cyclosporins; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy; Immunization, Passive; Immunosuppressive Agents; L-Lactate Dehydrogenase; Lung; Lymphocytes; Male; Monocrotaline; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1987 |
[Monocrotaline-induced pulmonary hypertension with special reference to the influence of dose, age, and sex].
Topics: Age Factors; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypertension, Pulmonary; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Sex Factors | 1985 |
[Reduction of the development of monocrotaline-induced pulmonary hypertension in rats by artificial unilateral pneumothorax].
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Monocrotaline; Pneumothorax, Artificial; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1985 |