monocrotaline and Disease Exacerbation

Topics: Animals; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Endothelial Cells; Extracellular Matrix; Glomerular Mesangium; Humans; Kidney; Monocrotaline; Renal Insufficiency, Chronic

Topics: Animals; Antioxidants; Apoptosis; Cell Survival; Collagen; Disease Progression; Electrocardiography; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Rats, Wistar; Thioredoxins

Topics: Animals; Blood Pressure; Capillary Permeability; Disease Models, Animal; Disease Progression; Endothelial Cells; Female; Heme; Hemolysis; HSP27 Heat-Shock Proteins; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Rats, Sprague-Dawley; Sex Characteristics; Tight Junctions

Topics: Animals; Arterial Pressure; Disease Models, Animal; Disease Progression; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Nitrosative Stress; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pulmonary Edema; Rats, Wistar; Receptor, Endothelin A; Time Factors; Vascular Remodeling; Vasodilation

Topics: Aminobutyrates; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Body Weight; Disease Models, Animal; Disease Progression; Drug Combinations; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Tetrazoles; Valsartan

Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Hepatic Veno-Occlusive Disease; Intercellular Adhesion Molecule-1; Liver Neoplasms; Male; Matrix Metalloproteinase 9; Monocrotaline; Rats, Inbred F344; Tumor Burden; Vascular Endothelial Growth Factor A

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chemistry, Pharmaceutical; Disease Progression; Hypertension, Pulmonary; Liposomes; Lung; Male; Monocrotaline; Myocytes, Smooth Muscle; Nitric Oxide Donors; Peptides; Polyamines; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents

Topics: Administration, Intravenous; Animals; Disease Progression; Drug Delivery Systems; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Leukocytes; Male; Monocrotaline; Nanoparticles; Pulmonary Artery; Quinolines; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome

Topics: Adolescent; Aldosterone; Animals; Child, Preschool; Cytokines; Disease Progression; Female; Fibrosis; Gene Expression Regulation; Humans; Hypertrophy; Lung; Male; Middle Aged; Monocrotaline; Neurotransmitter Agents; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Renin-Angiotensin System; Sympathectomy; Sympathetic Nervous System

Topics: Animals; Arterioles; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Echocardiography; Hemodynamics; Hypertension, Pulmonary; Liver; Male; Monocrotaline; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar

Topics: Adipose Tissue; Animals; Disease Progression; Gene Expression Profiling; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Rats, Wistar; Regenerative Medicine; RNA, Messenger; Stem Cell Transplantation; Survival Analysis; Vascular Remodeling; Weight Gain

Topics: Administration, Inhalation; Animals; Arterial Pressure; Cardiotonic Agents; Disease Models, Animal; Disease Progression; Dobutamine; Energy Metabolism; Heart Failure; Hexokinase; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; L-Lactate Dehydrogenase; Male; Mitochondria, Heart; Monocrotaline; Oxygen; Oxygen Consumption; Protoporphyrins; Pulmonary Artery; Rats, Wistar; Ventricular Dysfunction, Right; Ventricular Function, Right

Topics: Animals; Blood Pressure; Carnitine; Disease Models, Animal; Disease Progression; Glutathione; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Metabolic Networks and Pathways; Metabolome; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors

Topics: Animals; Arterial Pressure; Disease Models, Animal; Disease Progression; Energy Metabolism; Glycolysis; Hypertension, Pulmonary; Lipid Metabolism; Male; Metabolome; Methionine; Monocrotaline; Proton Magnetic Resonance Spectroscopy; Pulmonary Artery; Rats; Rats, Sprague-Dawley

Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Case-Control Studies; Disease Models, Animal; Disease Progression; Endothelin-1; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Liver; Lung; Male; Middle Aged; Monocrotaline; Niacinamide; Nicotinamide N-Methyltransferase; Nitric Oxide; Rats, Wistar; Signal Transduction; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right

Topics: Acetylcholine; Animals; Atorvastatin; Blotting, Western; Body Weight; Caspase 3; Celecoxib; Cyclooxygenase Inhibitors; Disease Progression; Drug Combinations; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Nitric Oxide Synthase Type III; Pulmonary Artery; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Sulfonamides; Survival Analysis; Vasodilator Agents

Topics: Animals; Blood Gas Analysis; Body Weight; Disease Progression; Fibroblast Growth Factor 2; Gelatin; Hemodynamics; Hydrogels; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Microspheres; Monocrotaline; Rats; Rats, Wistar; Trachea

Topics: Animals; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Image Processing, Computer-Assisted; Imidazoles; Immunohistochemistry; Monocrotaline; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pulmonary Artery; Quinoxalines; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Smad3 Protein; Transforming Growth Factor beta1

Topics: Animals; Benzamides; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell Movement; Chronic Disease; Disease Models, Animal; Disease Progression; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta

Topics: Adaptation, Physiological; Animals; Biopsy; Capillaries; Cardiac Catheterization; Cardiac Output; Coronary Circulation; Disease Models, Animal; Disease Progression; Echocardiography; Heart Failure; Hypertension, Pulmonary; Male; Monocrotaline; Myocarditis; Physical Conditioning, Animal; Physical Endurance; Rats; Rats, Wistar; Rest; Survival Rate

Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Propanolamines; Rats; Rats, Wistar; Sympathetic Nervous System; Ventricular Pressure

Topics: Animals; Blood Gas Analysis; Carbolines; Cyclic GMP; Disease Progression; Dose-Response Relationship, Drug; Hemodynamics; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Organ Size; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Poisons; Pulmonary Circulation; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Survival; Tadalafil

Topics: Animals; Disease Progression; Glucuronosyltransferase; Hyaluronan Synthases; Hyaluronic Acid; Hyaluronoglucosaminidase; Hypertension, Pulmonary; Lung; Male; Molecular Weight; Monocrotaline; Rats; Rats, Inbred F344

Topics: Animals; Cytosol; Disease Progression; Endothelial Cells; Gene Expression; Hypertension, Pulmonary; Inflammation; Male; Membrane Proteins; Monocrotaline; Nitric Oxide; Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors

Topics: Animals; Autoradiography; Disease Models, Animal; Disease Progression; Gallium Radioisotopes; Gene Expression Profiling; Heart Failure; Hypertrophy, Right Ventricular; Immunochemistry; Inflammation; Male; Monocrotaline; Myocardium; Neutrophil Activation; Peroxidase; Radionuclide Imaging; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Right

Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antihypertensive Agents; Bisoprolol; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Echocardiography; Fibrosis; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Wistar; Signal Transduction; Vascular Resistance

Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Case-Control Studies; Cells, Cultured; Disease Progression; Endothelium, Vascular; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Losartan; Male; Middle Aged; Monocrotaline; Myocytes, Smooth Muscle; Proportional Hazards Models; Rats; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Up-Regulation

Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Cytosol; Disease Progression; Humans; Hypertension, Pulmonary; Inositol Phosphates; Male; Monocrotaline; Myocytes, Smooth Muscle; Naphthalenes; Nifedipine; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; Recombinant Fusion Proteins; Signal Transduction; Transfection; Up-Regulation; Vasoconstriction

Topics: Angiotensin II; Animals; Apoptosis; Carnitine; Caspase 3; Caspase 9; Caspases; Cell Nucleus; Cells, Cultured; Cytoprotection; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Glucose Transporter Type 4; Heart Failure; In Situ Nick-End Labeling; Liver Function Tests; Male; Monocrotaline; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Muscular Disorders, Atrophic; Myosin Heavy Chains; Protein Isoforms; Rats; Rats, Sprague-Dawley; Sphingolipids; Staurosporine; Tumor Necrosis Factor-alpha

Topics: Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Body Weight; Densitometry; Disease Progression; Enalapril; Endothelin-1; Estrogens; Female; Hypertrophy, Right Ventricular; Male; Microscopy, Electron; Monocrotaline; Ovariectomy; Rats; Rats, Sprague-Dawley; Renin; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Sex Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ventricular Remodeling

Topics: Animals; Disease Models, Animal; Disease Progression; Echocardiography; Echocardiography, Doppler, Pulsed; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar

Topics: Administration, Oral; Animals; Cardiovascular Agents; Coronary Vessels; Disease Models, Animal; Disease Progression; Endothelin A Receptor Antagonists; Heart Failure; Hemodynamics; Hypertension, Pulmonary; Ligation; Male; Monocrotaline; Myocardial Infarction; Pulmonary Heart Disease; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Sulfonamides

Topics: 2-Methoxyestradiol; Animals; Blood Pressure; Body Weight; Cell Proliferation; Disease Progression; Estradiol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Time Factors; Tubulin Modulators

Topics: 2-Methoxyestradiol; Analysis of Variance; Animals; Blood Pressure; Disease Progression; Estradiol; Female; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Ovariectomy; Pulmonary Artery; Rats; Time Factors; Ventricular Function, Left; Ventricular Function, Right

Topics: Acetylcholine; Animals; Apoptosis; Blood Pressure; Blotting, Western; Body Weight; Caspase 3; Disease Progression; Endothelial Cells; Heart Function Tests; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; In Situ Nick-End Labeling; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Nitroprusside; Poisons; Pravastatin; Pulmonary Artery; Rats; Rats, Wistar; Survival; Vasodilator Agents

Topics: Animals; Cardiomegaly; Disease Models, Animal; Disease Progression; Heart Failure; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Cells; Myocardium; Prognosis; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Ventricular Pressure; Ventricular Remodeling

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Blood Vessels; Cell Adhesion; Cell Shape; Cells, Cultured; Cytoskeleton; Disease Progression; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Hypertension; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pulmonary Artery; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Stress, Mechanical; Tenascin; Transcription, Genetic; Vasoconstriction

Topics: Animals; Disease Models, Animal; Disease Progression; Heart Failure; Male; Monocrotaline; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Ultrasonography; Ventricular Dysfunction, Right

Topics: Animals; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Echocardiography; Endothelium, Vascular; Granulocyte Colony-Stimulating Factor; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Inbred F344

Topics: Animals; Apoptosis; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Protein Receptors, Type II; Cell Proliferation; Disease Models, Animal; Disease Progression; Down-Regulation; Hypertension, Pulmonary; Immunoblotting; Immunohistochemistry; Male; Monocrotaline; Polymerase Chain Reaction; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA; Signal Transduction; Smad4 Protein; Smad5 Protein; Smad6 Protein; Smad8 Protein

Topics: Animals; Atorvastatin; Blood Pressure; Disease Progression; Dose-Response Relationship, Drug; Drug Synergism; Echocardiography; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphorylation; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Simvastatin; Sirolimus

Topics: Animals; Antioxidants; Disease Progression; Hypertension, Pulmonary; Immunohistochemistry; Lung; Macrophages; Male; Monocrotaline; NF-kappa B; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Vascular Cell Adhesion Molecule-1

Topics: Animals; Coronary Vessels; Disease Models, Animal; Disease Progression; Enzyme Induction; Female; Free Radicals; Heart Failure; Heart Ventricles; Hypertrophy, Right Ventricular; Ligation; Monocrotaline; Muscle Proteins; Myocardial Infarction; Organ Size; Rats; Rats, Sprague-Dawley; Xanthine Oxidase

Topics: Animals; Anticholesteremic Agents; Blood Pressure; Diet; Disease Progression; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Probucol; Rats; Rats, Wistar; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure

Topics: Animals; Disease Progression; Hypertension, Pulmonary; Hypoxia; Male; Matrix Metalloproteinase 2; Models, Animal; Monocrotaline; Pulmonary Artery; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction