monocrotaline has been researched along with Cardiomegaly in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (39.73) | 18.7374 |
| 1990's | 18 (24.66) | 18.2507 |
| 2000's | 12 (16.44) | 29.6817 |
| 2010's | 13 (17.81) | 24.3611 |
| 2020's | 1 (1.37) | 2.80 |
| Authors | Studies |
|---|---|
| Angelovski, M; Hadzi-Petrushev, N; Kamkin, A; Mitrokhin, V; Mladenov, M; Rebok, K | 1 |
| Dong, S; Feng, Y; Jiang, Q; Li, J; Li, S; Li, T; Lin, W; Liu, B; Luo, H; Ou, Z; Qi, Q; Xu, Q; Yu, Z; Zeng, X; Zha, L; Zhang, M; Zhao, L | 1 |
| Belló-Klein, A; Bonetto, JHP; Boreham, D; Carraro, CC; da Rosa Araujo, AS; de Lima-Seolin, BG; Fernandes, RO; Khaper, N; Puukila, S; Türck, P | 1 |
| Belló-Klein, A; Bianchi, SE; Campos-Carraro, C; Colombo, R; Dos Santos Lacerda, D; Duarte Ortiz, V; Gazzi de Lima-Seolin, B; Linck Bassani, V; Poletto Bonetto, JH; Sander da Rosa Araujo, A; Türck, P | 1 |
| Hao, Y; Niu, Y; Sun, T; Wu, F; Xu, Y; Yan, L; Yang, J; Yao, W; Yu, J; Zhang, M; Zhou, R | 1 |
| Belló-Klein, A; Carraro, CC; Colombo, R; da Rosa Araujo, AS; de Lima-Seolin, BG; Lacerda, DS; Poletto Bonetto, JH; Schenkel, PC; Teixeira, RB; Türck, P | 1 |
| Balakin, AA; Kuznetsov, DA; Lisin, RV; Lukin, ON; Protsenko, YL | 1 |
| Adams, V; Boekschoten, MV; Bowen, TS; van Norren, K; Vinke, P; Witkamp, RF | 1 |
| Choi, YS; Kim, OS; Kweon, TD; Na, S; Oh, YJ; Ryoo, S; Shim, HS | 1 |
| Balakin, AA; Kuznetsov, DA; Lisin, RV; Protsenko, IuL | 1 |
| Balakin, AA; Kursanov, AG; Kuznetsov, DA; Lisin, RV; Lookin, ON; Mukhlynina, EA; Protsenko, YL | 1 |
| Beretta, L; Fumagalli, F; Latini, R; Masson, S; Santaniello, A; Scorza, R; Zambelli, V | 1 |
| Belló-Klein, A; Berger, B; Leichsenring-Silva, F; Llesuy, S; Mosele, F; Tavares, AM | 1 |
| Barreiro, EJ; do Nascimento, JH; Ferraz, EB; Fraga, CA; Kummerle, AE; Pereira, SL; Rocha, Nde N; Sudo, RT; Zapata-Sudo, G | 1 |
| Des Tombe, AL; Lee-De Groot, MB; Van Beek-Harmsen, BJ; Van Der Laarse, WJ | 1 |
| Goto, J; Ishikawa, K; Kawamura, K; Maruyama, Y; Matumoto, H; Sugawara, D; Watanabe, Y | 1 |
| Korstjens, IJ; Rouws, CH; Stienen, GJ; van der Laarse, WJ; Van der Zee, L | 1 |
| Farahmand, F; Hill, MF; Singal, PK | 1 |
| Eshiro, K; Matsumura, Y; Nishida, M; Okada, Y; Takaoka, M | 1 |
| Ishikawa, Y; Minamisawa, S; Shimura, M; Umemura, S; Yokoyama, U | 1 |
| Minami, S; Miyazaki, H; Mochizuki, S; Ohsawa, S; Okazaki, F; Onodera, T | 1 |
| Brendel, K; Duhamel, RC; Huxtable, RJ; Lafranconi, WM | 1 |
| Dauber, IM; Hyers, TM; McMurtry, IF; Reeves, JT; Sugita, T; Wagner, WW | 1 |
| Bryant, SE; Frost, HH; Migally, N; Tucker, A | 1 |
| Bruner, LH; Hilliker, KS; Roth, RA | 1 |
| Hilliker, KS; Roth, RA | 1 |
| Gauthier, D; Kay, JM; Keane, PM; Suyama, KL | 1 |
| Gamble, W; Meyrick, B; Reid, L | 1 |
| Bell, TG; Hilliker, KS; Roth, RA | 1 |
| Lai, YL; Zhou, KR | 1 |
| Roth, RA; Schultze, AE | 1 |
| Agnoletti, G; Albertini, A; Comini, L; Ferrari, R; Gaia, G; Mantero, G; Panzali, A; Pasini, E | 1 |
| Goto, K; Miyauchi, T; Sakai, S; Sakurai, T; Yorikane, R | 1 |
| Bernocchi, P; Ceconi, C; Curello, S; Ferrari, R; Pasini, E; Pedersini, P | 1 |
| Block, N; Brock, TA; Chen, SJ; Chen, YF; Dixon, RA; Munsch, CL; Sherwood, SJ; Tilton, RG; Wu, C | 1 |
| Brodde, OE; Gerbershagen, HP; Giessler, C; Heinroth-Hoffmann, I; Leineweber, K; Pönicke, K; Seyfarth, T | 1 |
| Panchal, RG; Petrou, S; Reilly, AM; Williams, DA | 1 |
| Cho, KW; Kim, SH; Kim, SZ; Kim, YA; Lee, KS; Seul, KH | 1 |
| Cho, KW; Han, JH; Kim, SH; Kim, SZ; Lee, SJ; Lim, SH | 1 |
| Johnson, WD; Lalich, JL; Raczniak, TJ; Shumaker, RC | 1 |
| Hashimoto, H; Ito, T; Kondo, J; Okumura, K; Shimizu, K; Toki, Y; Yoshino, M | 1 |
| Ishibashi-Ueda, H; Kanosue, K; Kawaguchi, AT; Kawashima, Y; Matsuda, H; Mizuta, T; Shirakura, R | 1 |
| Che, DY; Li, WY; Wang, HY | 1 |
| Kawaguchi, AT; Kawashima, Y; Matsuda, H; Mizuta, T; Nakahara, K; Shirakura, R; Tanaka, H | 2 |
| Goto, Y; Honda, M; Ishikawa, S; Ishinaga, Y; Kuzuo, H; Morioka, S; Moriyama, K; Yamada, S; Yoshikane, H | 1 |
| Honda, M; Ishikawa, S; Ishinaga, Y; Morioka, S; Moriyama, K; Tanaka, K; Yano, S | 1 |
| Honda, M; Ishikawa, S; Morioka, S; Moriyama, K; Yamada, S | 1 |
| Condorelli, E; Missale, C; Pelá, G; Raddino, R; Spano, PF; Visioli, O | 1 |
| Goto, Y; Honda, M; Ishikawa, S; Kuzuo, H; Morioka, S; Moriyama, K; Yamada, S | 1 |
| Roth, RA; Schultze, AE; Wagner, JG | 1 |
| Hashimoto, H; Ito, T; Okumura, K; Satake, T; Yamada, Y | 1 |
| Ono, S; Voelkel, NF | 1 |
| Gerdes, AM; McDonough, KH; Summer, WR; Werchan, PM | 1 |
| Gagnon, J; Hill, NS; Jederlinic, P | 1 |
| Altura, BM; Altura, BT; Mathew, R | 1 |
| Hubbard, AK; Huxtable, RJ; Shubat, PJ | 1 |
| Ceconi, C; Condorelli, E; Ferrari, R; Harris, P; Quinzanini, M; Rodella, A | 1 |
| Ito, T; Kira, Y; Murata, M; Okabe, F; Sekine, I; Takahashi, M | 1 |
| Baron, DA; Currie, MG; Kurtz, DT; Oehlenschlager, WF | 1 |
| Hinz, JM; Molteni, A; Ts'ao, CH; Ward, WF | 1 |
| Harding, SE; Jones, SM; Poole-Wilson, PA; Vescovo, G | 1 |
| Guarnieri, C; Muscari, C | 1 |
| Fink, GD; Ganey, PE; Roth, RA | 1 |
| Ganey, PE; Hadley, KB; Roth, RA; Sprugel, KH | 1 |
| Altiere, RJ; Gillespie, MN; O'Connor, WN; Olson, JW; Reinsel, CN | 1 |
| Cottrill, CM; Gillespie, MN; Johnson, GL | 1 |
| Roth, RA; White, SM | 1 |
| Altura, BM; Altura, BT; Gloster, ES; Mathew, R | 1 |
| Cookson, WO; Shale, DJ; Wiseman, MS | 1 |
| Molteni, A; Solliday, N; Ts'ao, C; Ward, W | 1 |
| Langleben, D; Reid, LM | 1 |
| Mullen, M; Olley, PM; Rabinovitch, M; Todd, L | 1 |
73 other study(ies) available for monocrotaline and Cardiomegaly
| Article | Year |
|---|---|
Antioxidant and anti-inflammatory effects of the monocarbonyl curcumin analogs B2BRBC and C66 in monocrotaline-induced right ventricular hypertrophy.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiomegaly; Curcumin; Male; Monocrotaline; Oxidative Stress; Rats; Rats, Wistar | 2019 |
Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling.
Topics: Animals; Apoptosis; Atorvastatin; Cardiomegaly; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Endoplasmic Reticulum Stress; Hemodynamics; Inflammation; Macrophages; Male; Mitochondria; Models, Biological; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Secoisolariciresinol diglucoside attenuates cardiac hypertrophy and oxidative stress in monocrotaline-induced right heart dysfunction.
Topics: Animals; Butylene Glycols; Cardiomegaly; Glucosides; Male; Monocrotaline; Oxidative Stress; Rats; Rats, Wistar; Ventricular Dysfunction, Right | 2017 |
Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cardiomegaly; Catalase; Echocardiography; Glutathione Peroxidase; Heart Ventricles; Hypertension, Pulmonary; Liver; Lung; Male; Monocrotaline; NADPH Oxidases; Oxidative Stress; Rats, Wistar; Stilbenes; Superoxide Dismutase; Systole; Ventricular Function | 2017 |
Protective effects of aloperin on monocroline-induced pulmonary hypertension via regulation of Rho A/Rho kinsase pathway in rats.
Topics: Animals; bcl-2-Associated X Protein; Cardiomegaly; Cyclin-Dependent Kinase Inhibitor p27; Electrocardiography; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Piperidines; Proliferating Cell Nuclear Antigen; Protective Agents; Pulmonary Artery; Quinolizidines; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Vascular Remodeling | 2017 |
Trapidil improves hemodynamic, echocardiographic and redox state parameters of right ventricle in monocrotaline-induced pulmonary arterial hypertension model.
Topics: Animals; Blood Pressure; Calcium; Cardiac Catheterization; Cardiomegaly; Disease Models, Animal; Echocardiography; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Oxidation-Reduction; Rats, Wistar; Trapidil | 2018 |
Effect of Calcium on Slow Force Responses in Isolated Right Ventricle Preparations of Healthy and Hypertrophied Myocardium in Male and Female Rats.
Topics: Animals; Calcium Chloride; Cardiomegaly; Female; Heart Ventricles; Isometric Contraction; Male; Monocrotaline; Myocardial Contraction; Myocardium; Rats; Rats, Wistar; Sex Factors; Time Factors; Tissue Culture Techniques | 2018 |
Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Female; Fibrosis; Heart; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Skeletal; Pulmonary Arterial Hypertension; Pulmonary Artery; Vascular Remodeling; Ventricular Function, Right | 2019 |
Cervical ganglion block attenuates the progression of pulmonary hypertension via nitric oxide and arginase pathways.
Topics: Amides; Anesthetics, Local; Animals; Arginase; Autonomic Nerve Block; Blood Pressure; Cardiomegaly; Ganglia, Sympathetic; Hypertension, Pulmonary; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Ropivacaine; Superior Cervical Ganglion | 2014 |
[Characteristics of load dependent relaxation of normal and hypertrophied myocardium in male and female rats].
Topics: Animals; Cardiomegaly; Female; Heart Ventricles; Male; Monocrotaline; Myocardial Contraction; Myocardium; Rats; Rats, Wistar; Sex Characteristics | 2014 |
Contractility of Right Ventricular Myocardium in Male and Female Rats during Physiological and Pathological Hypertrophy.
Topics: Animals; Cardiomegaly; Cell Size; Female; Heart; Heart Ventricles; Isometric Contraction; Isotonic Contraction; Male; Monocrotaline; Myocardial Contraction; Myocytes, Cardiac; Rats; Rats, Wistar; Sex Characteristics; Swimming | 2017 |
Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension.
Topics: 4-Aminobenzoic Acid; Animals; Body Weight; Cardiomegaly; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; para-Aminobenzoates; Pulmonary Artery; Rats; Rats, Wistar; Survival Analysis | 2011 |
Association of the time course of pulmonary arterial hypertension with changes in oxidative stress in the left ventricle.
Topics: Animals; Ascorbic Acid; Cardiomegaly; Familial Primary Pulmonary Hypertension; Glutathione; Heart Ventricles; Hydrogen Peroxide; Hypertension, Pulmonary; Male; Monocrotaline; Oxidative Stress; Rats; Rats, Wistar; Thioredoxin-Disulfide Reductase; Ultrasonography | 2011 |
A novel Ca2+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension.
Topics: Acetylcholine; Animals; Benzodioxoles; Calcium Channel Blockers; Calcium Chloride; Cardiomegaly; Familial Primary Pulmonary Hypertension; Hydrazones; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Phenylephrine; Pulmonary Artery; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents | 2013 |
Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium.
Topics: Animals; Calibration; Cardiomegaly; Disease Models, Animal; Histocytochemistry; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Male; Monocrotaline; Myocardium; Myocytes, Cardiac; Myoglobin; Oxygen Consumption; Rats; Rats, Wistar; Succinate Dehydrogenase; Time Factors; Transcription Factors | 2002 |
Heme oxygenase-1 reduces murine monocrotaline-induced pulmonary inflammatory responses and resultant right ventricular overload.
Topics: Animals; Body Weight; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypertension, Pulmonary; Inflammation; Lung; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Monocrotaline; Myocytes, Cardiac; Rats; Stress, Mechanical; Ventricular Function, Right | 2002 |
Myocardial force development and structural changes associated with monocrotaline induced cardiac hypertrophy and heart failure.
Topics: Animals; Cardiomegaly; Heart Failure; In Vitro Techniques; Male; Monocrotaline; Myocardial Contraction; Myocardium; Rats; Rats, Wistar | 2002 |
Antioxidant and oxidative stress changes in experimental cor pulmonale.
Topics: Animals; Antioxidants; Cardiomegaly; Catalase; Disease Models, Animal; Glutathione Peroxidase; Heart Ventricles; Lipid Peroxidation; Liver; Lung; Male; Monocrotaline; Organ Size; Oxidative Stress; Pulmonary Heart Disease; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Time Factors; Ventricular Pressure | 2004 |
Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Atrasentan; Blood Pressure; Body Mass Index; Body Weight; Cardiomegaly; Drug Administration Schedule; Drug Therapy, Combination; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Intubation, Gastrointestinal; Lung; Male; Monocrotaline; Organ Size; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors; Tunica Media; Ventricular Pressure | 2004 |
Mechanical stress-dependent transcriptional regulation of sarcolipin gene in the rodent atrium.
Topics: Animals; Aorta; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cardiomegaly; Constriction, Pathologic; Down-Regulation; Gene Expression Regulation; Heart Atria; Male; Mice; Monocrotaline; Muscle Proteins; Organ Size; Proteolipids; Rats; Rats, Wistar; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Stress, Mechanical | 2005 |
Myocyte morphological characteristics differ between the phases of pulmonary hypertension-induced ventricular hypertrophy and failure.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Disease Progression; Heart Failure; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Cells; Myocardium; Prognosis; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Ventricular Pressure; Ventricular Remodeling | 2006 |
Differentiation of the cardiac and pulmonary toxicity of monocrotaline, a pyrrolizidine alkaloid.
Topics: Animals; Cardiomegaly; Collagen; DNA; Female; Hydroxyproline; Lipid Metabolism; Lung Diseases; Male; Monocrotaline; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; RNA | 1984 |
Lung vessel leak precedes right ventricular hypertrophy in monocrotaline-treated rats.
Topics: Albumins; Altitude; Animals; Cardiomegaly; Lung; Male; Monocrotaline; Pressure; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serum Albumin; Vascular Diseases | 1983 |
Chemical sympathectomy and serotonin inhibition reduce monocrotaline-induced right ventricular hypertrophy in rats.
Topics: Animals; Cardiomegaly; Fenclonine; Hydroxydopamines; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Oxidopamine; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin Antagonists; Sympathectomy, Chemical | 1983 |
Pulmonary hypertension and ECG changes from monocrotaline pyrrole in the rat.
Topics: Animals; Blood Cell Count; Body Weight; Cardiomegaly; Electrocardiography; Heart; Heart Ventricles; Hypertension, Pulmonary; Kinetics; Lung; Male; Monocrotaline; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1983 |
Alteration of monocrotaline pyrrole-induced cardiopulmonary effects in rats by hydrallazine, dexamethasone or sulphinpyrazone.
Topics: Animals; Body Weight; Cardiomegaly; Dexamethasone; Heart Diseases; Hydralazine; L-Lactate Dehydrogenase; Lung; Lung Diseases; Monocrotaline; Myocardium; Organ Size; Pyrrolizidine Alkaloids; Rats; Sulfinpyrazone | 1984 |
Angiotensin converting enzyme activity and evolution of pulmonary vascular disease in rats with monocrotaline pulmonary hypertension.
Topics: Animals; Arterioles; Blood Pressure; Cardiomegaly; Female; Hypertension, Pulmonary; Lung; Monocrotaline; Muscle, Smooth, Vascular; Peptidyl-Dipeptidase A; Pulmonary Artery; Pulmonary Heart Disease; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1982 |
Development of Crotalaria pulmonary hypertension: hemodynamic and structural study.
Topics: Animals; Blood Gas Analysis; Body Temperature; Cardiomegaly; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Circulation; Pyrroles; Pyrrolizidine Alkaloids; Rats | 1980 |
Pneumotoxicity and thrombocytopenia after single injection of monocrotaline.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Platelet Disorders; Body Weight; Cardiomegaly; Dose-Response Relationship, Drug; Lung; Male; Monocrotaline; Perfusion; Plants, Toxic; Platelet Count; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio | 1982 |
Capsaicin pretreatment attenuates monocrotaline-induced ventilatory dysfunction and pulmonary hypertension.
Topics: Animals; Blood Pressure; Body Weight; Capsaicin; Cardiomegaly; Endopeptidases; Hypertension, Pulmonary; Monocrotaline; Nerve Fibers; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Respiratory Tract Diseases; Substance P | 1993 |
Fibrinolytic activity in blood and lungs of rats treated with monocrotaline pyrrole.
Topics: alpha-2-Antiplasmin; Animals; Cardiomegaly; Fibrinolysis; Lung; Male; Monocrotaline; Plasminogen; Plasminogen Inactivators; Rats; Rats, Sprague-Dawley; Tissue Plasminogen Activator | 1993 |
Activation of ANP synthesis during congestive heart failure in rats treated with monocrotaline.
Topics: Animals; Ascitic Fluid; Atrial Natriuretic Factor; Cardiomegaly; Female; Gene Expression; Heart Failure; Hypertrophy, Right Ventricular; Monocrotaline; Myocardium; Organ Specificity; Pleural Effusion; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
Possible involvement of endothelin-1 in cardiac hypertrophy.
Topics: Animals; Aorta, Thoracic; Aortic Valve Insufficiency; Cardiomegaly; Endothelins; Hypertension, Pulmonary; Hypertrophy, Left Ventricular; Male; Models, Biological; Monocrotaline; Myocardium; Rats; Rats, Wistar; RNA, Messenger | 1994 |
Skeletal muscle metabolism in experimental heart failure.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Disease Models, Animal; Female; Heart Failure; Monocrotaline; Muscle, Skeletal; NAD; Organ Size; Oxidation-Reduction; Phosphocreatine; Rats; Rats, Sprague-Dawley | 1996 |
Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Isoxazoles; Male; Monocrotaline; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Thiophenes; Vasoconstriction; Weight Gain | 2000 |
The cardiac beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in monocrotaline-treated rats.
Topics: Adenylyl Cyclases; Animals; Blood Pressure; Blotting, Western; Body Weight; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; GTP-Binding Proteins; Humans; Kinetics; Male; Monocrotaline; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Muscarinic; Time Factors | 2000 |
Restoration of calcium handling properties of adult cardiac myocytes from hypertrophied hearts.
Topics: Adenoviridae Infections; Animals; Calcium; Calcium-Transporting ATPases; Cardiomegaly; Cells, Cultured; Genetic Vectors; Heart Ventricles; Humans; Injections, Intraperitoneal; Male; Monocrotaline; Myocardium; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2001 |
Accentuation of ANP secretion to endothelin-1 in hypertrophied atria.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Extracellular Space; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Statistics as Topic; Stress, Mechanical; Time Factors | 2001 |
Attenuation of inhibitory effect of CNP on the secretion of ANP from hypertrophied atria.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Cyclic GMP; Extracellular Space; Guanylate Cyclase; Heart Atria; In Vitro Techniques; Male; Monocrotaline; Myocardium; Natriuretic Peptide, C-Type; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor | 2001 |
Fibrin thrombosis in monocrotaline pyrrole-induced cor pulmonale in rats.
Topics: Animals; Cardiomegaly; Endothelium; Fibrin; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Embolism; Pulmonary Heart Disease; Pyrroles; Pyrrolizidine Alkaloids; Rats | 1977 |
Changes in ventricular 1,2-diacylglycerol content in rats following monocrotaline treatment.
Topics: Animals; Cardiomegaly; Diglycerides; DNA; Fatty Acids; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Lipid Metabolism; Male; Monocrotaline; Myocardium; Osmolar Concentration; Rats; Rats, Wistar; RNA | 1992 |
Single lung transplantation in rats with fatal pulmonary hypertension.
Topics: Animals; Cardiac Output; Cardiomegaly; Exercise Test; Follow-Up Studies; Hypertension, Pulmonary; Lung Transplantation; Male; Monocrotaline; Oxygen Consumption; Postoperative Complications; Pulmonary Edema; Rats; Rats, Inbred Lew; Time Factors; Transplantation, Isogeneic | 1992 |
The preventive effect of radix Salciae miltiorrhizae on monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Cardiomegaly; Drug Combinations; Drugs, Chinese Herbal; Female; Hypertension, Pulmonary; Male; Monocrotaline; Phenanthrolines; Plant Extracts; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 1992 |
Single lung transplantation in rats with chemically induced pulmonary hypertension.
Topics: Animals; Cardiomegaly; Exercise Test; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Lung Transplantation; Male; Monocrotaline; Oxygen Consumption; Rats; Rats, Inbred Lew | 1992 |
Biochemical and structural remodeling of collagen in the right ventricular hypertrophy induced by monocrotaline.
Topics: Animals; Blood Pressure; Cardiomegaly; Collagen; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Heart Ventricles; Male; Microscopy, Electron, Scanning; Monocrotaline; Myocardium; Rats; Rats, Inbred Strains | 1992 |
Changes in contractile and non-contractile proteins, intracellular Ca2+ and ultrastructures during the development of right ventricular hypertrophy and failure in rats.
Topics: Animals; Calcium; Cardiomegaly; Collagen; Heart Failure; Hypertension, Pulmonary; Male; Microscopy, Electron, Scanning; Mitochondria, Heart; Monocrotaline; Myocardial Contraction; Myocardium; Myosins; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum | 1992 |
Biventricular down-regulation of beta-adrenergic receptors in right ventricular hypertrophy induced by monocrotaline.
Topics: Animals; Cardiomegaly; Down-Regulation; Epinephrine; Heart Failure; Heart Ventricles; Male; Monocrotaline; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1991 |
Beta 1- and beta 2-receptors are differentially desensitized in an experimental model of heart failure.
Topics: Adenylyl Cyclases; Animals; Autoradiography; Cardiac Output, Low; Cardiomegaly; Cardiomyopathies; Female; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Iodocyanopindolol; Monocrotaline; Pindolol; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1990 |
Changes in contractile and noncontractile protein metabolisms in both ventricles in monocrotaline-treated rats.
Topics: Animals; Cardiomegaly; Collagen; Electrophoresis, Polyacrylamide Gel; Heart Ventricles; Injections, Subcutaneous; Isoenzymes; Monocrotaline; Myosins; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1991 |
Effects of single-lung transplantation on chemically induced pulmonary hypertension in the rat.
Topics: Animals; Cardiomegaly; Hypertension, Pulmonary; Lung Transplantation; Monocrotaline; Oxygen Consumption; Physical Exertion; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Lew | 1991 |
An evaluation of procoagulant activity in the peripheral blood of rats treated with monocrotaline pyrrole.
Topics: Animals; Blood Coagulation; Body Weight; Bronchoalveolar Lavage Fluid; Cardiomegaly; Injections, Intravenous; Lung; Male; Monocrotaline; Organ Size; Partial Thromboplastin Time; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1991 |
Altered myocardial acetylcholine and norepinephrine concentrations in right ventricular hypertrophy and failure.
Topics: Acetylcholine; Animals; Cardiomegaly; Heart; Heart Failure; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Myocardial Contraction; Norepinephrine; Rats; Rats, Inbred Strains | 1991 |
PAF antagonists inhibit monocrotaline-induced lung injury and pulmonary hypertension.
Topics: Animals; Azepines; Cardiomegaly; Hypertension, Pulmonary; Lung; Lung Injury; Male; Monocrotaline; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles | 1991 |
Right ventricular performance after monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiomegaly; Heart; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Myocardium; Organ Size; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1989 |
Supplemental oxygen reduces right ventricular hypertrophy in monocrotaline-injected rats.
Topics: Animals; Cardiomegaly; Hypertension, Pulmonary; Hypoxia; Lung Injury; Male; Monocrotaline; Oxygen Inhalation Therapy; Plants, Toxic; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio | 1989 |
Strain differences in pulmonary hypertensive response to monocrotaline alkaloid and the beneficial effect of oral magnesium treatment.
Topics: Animals; Cardiomegaly; Hypertension, Pulmonary; Magnesium; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Species Specificity; Weight Gain | 1989 |
Dose-response relationship in intoxication by the pyrrolizidine alkaloid monocrotaline.
Topics: Administration, Oral; Animals; Bronchoalveolar Lavage Fluid; Cardiomegaly; Dose-Response Relationship, Drug; Drug Interactions; Lung Diseases; Male; Monocrotaline; Organ Size; Phenobarbital; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1989 |
Noradrenaline, atrial natriuretic peptide, bombesin and neurotensin in myocardium and blood of rats in congestive cardiac failure.
Topics: Animals; Atrial Natriuretic Factor; Bombesin; Cardiomegaly; Heart Atria; Heart Failure; Heart Ventricles; Monocrotaline; Myocardium; Neurotensin; Norepinephrine; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1989 |
Pathological analysis of the right ventricular hypertrophy and ventricular interdependence in autopsied hearts with cor pulmonale and pulmonary hypertensive rat hearts.
Topics: Adult; Aged; Animals; Blood Pressure; Cardiomegaly; Female; Heart; Heart Septum; Heart Ventricles; Humans; Hypertension, Pulmonary; Male; Middle Aged; Monocrotaline; Myocardium; Organ Size; Pulmonary Heart Disease; Pulmonary Wedge Pressure; Pyrrolizidine Alkaloids; Rats | 1989 |
Enhanced activity of the cardiac endocrine system during right ventricular hypertrophy.
Topics: Animals; Atrial Natriuretic Factor; Autoradiography; Cardiomegaly; Hypertension, Pulmonary; Immunoblotting; Male; Monocrotaline; Myocardium; Pyrrolizidine Alkaloids; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; RNA, Messenger | 1989 |
Monocrotaline-induced cardiopulmonary injury in rats. Modification by the neutrophil elastase inhibitor SC39026.
Topics: Animals; Cardiomegaly; Chlorobenzoates; Epoprostenol; Hydroxyproline; Lung Diseases; Male; Monocrotaline; Organ Size; Pancreatic Elastase; Peptidyl-Dipeptidase A; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Thromboxane A2; Tissue Plasminogen Activator | 1989 |
Isoproterenol sensitivity of isolated cardiac myocytes from rats with monocrotaline-induced right-sided hypertrophy and heart failure.
Topics: Animals; Calcium-Transporting ATPases; Cardiomegaly; Catecholamines; Cells, Cultured; Disease Models, Animal; Drug Tolerance; Heart; Heart Failure; Heart Ventricles; Isoproterenol; Male; Monocrotaline; Myocardial Contraction; Myocardium; Myosins; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1989 |
Beneficial effects of trimetazidine on mitochondrial function and superoxide production in the cardiac muscle of monocrotaline-treated rats.
Topics: Animals; Cardiomegaly; Electron Transport; Lipid Peroxides; Male; Mitochondria, Heart; Monocrotaline; Oxidative Phosphorylation; Oxygen Consumption; Piperazines; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Superoxides; Trimetazidine | 1988 |
The effect of dietary restriction and altered sodium intake on the cardiopulmonary toxicity of monocrotaline pyrrole.
Topics: Animals; Biotransformation; Body Weight; Cardiomegaly; Diet; Diet, Sodium-Restricted; L-Lactate Dehydrogenase; Lung Diseases; Male; Monocrotaline; Organ Size; Proteins; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Sodium | 1985 |
Monocrotaline pyrrole-induced cardiopulmonary toxicity is not altered by metergoline or ketanserin.
Topics: Angiotensin II; Animals; Blood Platelets; Blood Pressure; Cardiomegaly; Ergolines; Ketanserin; Lung; Male; Metergoline; Monocrotaline; Organ Size; Piperidines; Pyrrolizidine Alkaloids; Rats; Receptors, Serotonin; Serotonin | 1986 |
Vascular hyperresponsiveness in perfused lungs from monocrotaline-treated rats.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Perfusion; Pulmonary Artery; Pulmonary Circulation; Pulmonary Edema; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Vasoconstriction | 1986 |
Echocardiographic detection of pulmonary hypertension in anesthetized rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Echocardiography; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1988 |
Pulmonary platelet sequestration is increased following monocrotaline pyrrole treatment of rats.
Topics: Animals; Blood Platelets; Cardiomegaly; Cell Survival; Hemoglobins; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 1988 |
Magnesium aspartate hydrochloride attenuates monocrotaline-induced pulmonary artery hypertension in rats.
Topics: Animals; Aspartic Acid; Blood Pressure; Cardiomegaly; Hypertension, Pulmonary; Magnesium; Male; Monocrotaline; Organ Size; Plants, Toxic; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio | 1988 |
Effect of monocrotaline ingestion on the distribution of protein and angiotensin converting enzyme activity in the rat lung.
Topics: Animals; Cardiomegaly; Dose-Response Relationship, Drug; Male; Monocrotaline; Peptidyl-Dipeptidase A; Proteins; Pulmonary Alveoli; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1986 |
Monocrotaline-induced cardiopulmonary injury in rats: modification by thiol and nonthiol ACE inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Cardiomegaly; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Organ Size; Peptidyl-Dipeptidase A; Pyrrolizidine Alkaloids; Rats; Sulfhydryl Compounds | 1987 |
Effect of methylprednisolone on monocrotaline-induced pulmonary vascular disease and right ventricular hypertrophy.
Topics: Animals; Body Weight; Cardiomegaly; Heart Ventricles; Hypertension, Pulmonary; Male; Methylprednisolone; Monocrotaline; Pulmonary Heart Disease; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1985 |
Pulmonary toxicity of monocrotaline differs at critical periods of lung development.
Topics: Aging; Animals; Animals, Newborn; Cardiomegaly; Female; Forecasting; Lung; Male; Monocrotaline; Pulmonary Circulation; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1985 |