monocrotaline has been researched along with Cardiac Remodeling, Ventricular in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (14.86) | 29.6817 |
| 2010's | 42 (56.76) | 24.3611 |
| 2020's | 21 (28.38) | 2.80 |
| Authors | Studies |
|---|---|
| Crossman, DJ; Han, JC; Howe, K; Loiselle, DS; Ross, JM | 1 |
| Adekunle, AO; Adu-Amankwaah, J; Adzika, GK; Duah, M; Ma, Y; Mprah, R; Ndzie Noah, ML; Okwuma, JD; Qiao, W; Wang, C; Wowui, PI | 1 |
| Chen, X; Han, X; Liu, X; Qu, C; Ran, Q; Shi, S; Sun, Y; Wan, W; Wang, X; Yang, B; Ye, T; Zhang, C; Zhao, X | 1 |
| Chen, S; Cui, H; Du, GQ; Li, Y; Shen, W; Sun, P; Wang, C; Xue, JY; Zhao, P | 1 |
| Chang, R; Cui, B; Fan, Z; Hiram, R; Huang, C; Huang, H; Liu, T; Shi, S; Su, X; Tang, Y; Wu, G; Wu, J; Xiong, F; Yan, M; Zhang, W | 1 |
| Lin, S; Ma, H; Ye, P; Yu, WD; Zhang, AK; Zheng, YG | 1 |
| Carvalho, MR; Martinez, PF; Ogura, AY; Oliveira-Junior, SA | 1 |
| Boehm, M; Bonnet, S; Bourgeois, A; Dabral, S; de Man, F; Friedrich, A; Grobs, Y; Guenther, S; Jafari, L; Janssen, W; Khassafi, F; Kojonazarov, B; Kuenne, C; Looso, M; Maroli, G; Nayakanti, SR; Provencher, S; Pullamsetti, SS; Sarode, P; Savai, R; Schermuly, RT; Seeger, W; Tello, K; Weiss, A; Wietelmann, A; Wilhelm, J | 1 |
| Hanif, K; Jagavelu, K; Shafiq, M; Singh, N | 1 |
| Guo, Y; Sun, Y; Wang, X; Zhang, N; Zhao, H | 1 |
| Chen, H; Gao, X; He, K; Li, C; Li, H; Li, X; Liu, C; Wei, Q; Zhang, Z | 1 |
| Frede, W; Freichel, M; Gorenflo, M; Medert, R; Poth, T; Uhl, S; Vennekens, R | 1 |
| Chen, X; Dong, F; Guo, Z; Peng, Y; Zhang, J; Zhang, S; Zhu, L | 1 |
| Abe, K; Aoki, M; Aoki-Shoi, N; Bo, Z; Go, T; Hiraishi, K; Hirano, K; Inoue, R; Ishikawa, K; Kishi, H; Kobayashi, S; Koga, K; Kurahara, LH; Toru, S; Yahiro, E; Yamamura, A; Yokomise, H; Zhang, Y | 1 |
| Kaisho, M; Okada, M; Otani, K; Sugiyama, A; Yamawaki, H | 1 |
| Cheng, TT; Chiu, MH; Fang, SY; Hsu, CH; Huang, CC; Lam, CF; Lin, MW; Roan, JN | 1 |
| Higuchi, T; Inagaki, T; Masaki, T; Nakaoka, Y; Pearson, JT; Saito, S; Schwenke, DO; Shirai, M; Tsuchimochi, H; Umetani, K | 1 |
| Banerjee, S; Clark, VR; Fishbein, G; Hong, J; Park, JF; Razee, A; Saddic, L; Umar, S; Williams, T | 1 |
| Borges, RS; Duarte, GP; Gonzaga-Costa, K; Lahlou, S; Magalhães, PJC; Rebouça, CDSM; Rodrigues-Silva, MJ; Vasconcelos-Silva, AA | 1 |
| Chen, A; Ding, S; He, F; Kong, L; Lin, X; Ru, C; Xu, J | 1 |
| Li, XT; Li, YL; Li, YQ; Lin, XY; Ren, XQ; Yang, DL; Zeng, FQ | 1 |
| Antigny, F; Boët, A; Colsch, B; Delaporte, A; Fadel, E; Fenaille, F; Haddad, F; Hautbergue, T; Humbert, M; Junot, C; Lambert, M; Masson, B; Menager, JB; Mercier, O; Pavec, JL; Savale, L | 1 |
| Chen, Y; Deng, Y; Gao, X; Guo, S; Liu, C; Wei, B; Wu, W | 1 |
| He, J; Li, T; Li, X; Liu, Y; Luo, H; Qi, Q; Yu, Z; Zhao, L | 1 |
| Araujo, ASDR; Belló-Klein, A; Carraro, CC; Colombo, R; Conzatti, A; de Castro, AL; Fernandes, TRG; Siqueira, R; Tavares, AMV | 1 |
| Higuchi, M; Hikasa, Y; Leong, ZP; Okida, A; Yamano, Y | 1 |
| Li, L; Li, Y; Shi, F; Wang, L; Yang, D | 1 |
| Geng, S; Huang, Y; Lu, Z; Sun, F; Xu, L; Xu, M; Zhang, Y; Zhuang, P | 1 |
| Han, H; He, M; Kong, H; Wang, H; Wang, J; Xie, W; Xu, J | 1 |
| Alencar, AKN; Costa, DG; Cunha, VDMN; Fraga, AGM; Fraga, CAM; Groban, L; Martinez, ST; Mendes, LVP; Montagnoli, TL; Montes, GC; Silva, AMS; Sudo, RT; Trachez, MM; Wang, H; Zapata-Sudo, G | 1 |
| Hikasa, Y; Leong, ZP | 1 |
| Belló-Klein, A; Campos-Carraro, C; Corssac, GB; da Rosa Araujo, AS; de Lima-Seolin, BG; Dos Santos Lacerda, D; Hickmann, A; Llesuy, S; Tavares, AMV; Teixeira, RB; Turck, P | 1 |
| Ding, XY; Guo, DC; Li, C; Li, YD; Lu, XZ; Shi, YP; Wang, YD; Wu, XP | 1 |
| Abe, K; Hirano, K; Hirano, M; Hirooka, Y; Kuwabara, Y; Sunagawa, K; Tanaka-Ishikawa, M; Tsutsui, H | 1 |
| Chen, X; Hu, Q; Huang, L; Zhou, W | 1 |
| Duan, YL; Ge, SL; Gong, WH; Liu, Z; Xu, JJ; Zhang, CX | 1 |
| Ishihara, M; Takase, B; Tanaka, Y; Yao, T | 1 |
| Chen, YF; Creighton, JR; Fu, J; Guo, Y; Hage, FG; Oparil, S; Xing, DD; Zhao, X | 1 |
| Benoist, D; Benson, AP; Bernus, O; Cazorla, O; Drinkhill, MJ; Fowler, ED; Hardy, ME; Saint, DA; Stones, R; White, E | 1 |
| Alemanni, M; Altomare, C; Barile, L; Cornaghi, L; Gobbi, M; Latini, R; Lucchetti, J; Mostacciuolo, G; Rizzetto, R; Rocchetti, M; Ronchi, C; Russo, I; Sala, L; Staszewsky, LI; Zambelli, V; Zaza, A | 1 |
| Ma, H; Rong, S; Wang, X; Wang, Y | 1 |
| Bruce, E; Espejo, A; Francis, J; Horowitz, A; Katovich, MJ; Nair, A; Oswalt, A; Raizada, MK; Rathinasabapathy, A; Shenoy, V; Steckelings, UM; Sumners, C; Unger, T | 1 |
| Li, S; Li, XW; Wang, XM; Yang, JR | 1 |
| Araújo, AS; Belló-Klein, A; Colombo, R; Conzatti, A; Fernandes, TR; Siqueira, R; Tavares, AM | 1 |
| Jiang, Y; Ye, L; Zuo, X | 1 |
| Amado, F; Duarte, JA; Ferreira, R; Fonseca, H; Gonçalves, N; Henriques-Coelho, T; Leite-Moreira, AF; Moreira-Gonçalves, D; Moreno, N; Padrão, AI; Santos, M; Silva, AF; Vasques-Nóvoa, F; Vieira, S | 1 |
| Chen, C; Dong, W; Lin, X; Lv, S; Tong, G; Wang, X; Yang, D; Yang, Y | 1 |
| Duarte, JA; Ferreira, R; Henriques-Coelho, T; Leite-Moreira, A; Moreira-Gonçalves, D; Nogueira-Ferreira, R; Silva, AF | 1 |
| Baldus, S; Behringer, A; Berghausen, EM; Blaschke, F; Caglayan, E; Er, F; Gassanov, N; Kappert, K; Odenthal, M; Rosenkranz, S; Ten Freyhaus, H; Trappiel, M; Wellnhofer, E | 1 |
| Guo, B; Li, XW; Shen, YY; Yang, JR | 1 |
| Jan Bogaard, H; Jiang, R; Jing, ZC; Sun, XQ; Wang, L; Wang, XJ; Yuan, P; Zhang, HD; Zhang, R; Zhao, QH | 1 |
| Costa, R; Ducret, T; Ferreira, R; Ferreira-Pinto, MJ; Henriques-Coelho, T; Justino, J; Leite-Moreira, AF; Moreira-Gonçalves, D; Nogueira-Ferreira, R; Quignard, JF; Savineau, JP; Silva, AF; Vitorino, R | 1 |
| Ellinghaus, P; Janssen, W; Kast, R; Klein, M; Kramer, F; Lustig, K; Milting, H; Schäfer, S | 1 |
| He, JG; Tan, XY | 1 |
| den Adel, B; Hessel, M; Schutte, C; Steendijk, P; van der Laarse, A | 1 |
| Atsma, DE; Bax, WH; de Visser, YP; Laghmani, el H; Mantikou, E; Pijnappels, DA; Schalij, MJ; Schutte, CI; Steendijk, P; Umar, S; van der Laarse, A; van der Wall, EE; Wagenaar, GT | 1 |
| Hara, Y; Harada, T; Kikuzuki, R; Okada, M; Yamawaki, H | 1 |
| Musters, RJ; Paulus, WJ; Redout, EM; Simonides, WS; van de Kolk, CW; van der Toorn, A; van Echteld, CJ; van Hardeveld, C; Zuidwijk, MJ | 1 |
| Angeli, FS; Bernstein, HS; Boyle, AJ; De Marco, T; Jahn, S; Koskenvuo, JW; Mirsky, R; Ritner, C; Sievers, RE; Yeghiazarians, Y; Yim, SM | 1 |
| Cornitescu, T; Dahal, BK; Ghofrani, HA; Grimminger, F; Hoffmann, J; Kaulen, C; Kosanovic, D; Kuebler, WM; Reiss, I; Savai, R; Schermuly, RT; Seeger, W; Weissmann, N | 1 |
| Brandes, RP; Cornitescu, T; Dahal, BK; Davie, N; Ghofrani, HA; Grimminger, F; Janssen, W; Kojonazarov, B; Kosanovic, D; Luitel, H; Schermuly, RT; Seeger, W; Sydykov, A; Weissmann, N | 1 |
| Atli, O; Burukoglu, D; Ilgin, S; Sirmagul, B | 1 |
| Anderson, ME; Chen, B; Grumbach, IM; Guo, A; Li, Y; Sanders, P; Song, LS; Wang, LC; Weiss, RM; Xie, YP; Zimmerman, K | 1 |
| Baker, KM; Gupta, S; Jones, WK; Kim, IK; Kumar, R; Kumar, S; Seqqat, R; Thomas, CM; Wei, C | 1 |
| Araujo, AS; Belló-Klein, A; Caron-Lienert, R; Colombo, R; Mosele, F; Ribeiro, MF; Tavares, AM | 1 |
| Eghbali, M; Iorga, A; Matori, H; Nadadur, RD; Partow-Navid, R; Umar, S; Wong, G | 1 |
| Anderson, T; Campen, MJ; Candelaria, G; Hesterman, J; Hoppin, J; Irwin, D; Lucas, S; Norenberg, J; Paffett, ML | 1 |
| Araujo, AS; Becker, CU; Belló-Klein, A; Colombo, R; Fernandes, TG; Pires, KM; Siqueira, R; Souza-Rabbo, MP; Valença, SS | 1 |
| Ahn, BH; Cho, HG; Lee, HA; Lee, WJ; Lee, YM; Park, HK; Yang, EK | 1 |
| Ermert, L; Ghofrani, HA; Grimminger, F; Kreisselmeier, KP; Pullamsetti, S; Samidurai, A; Schermuly, RT; Schudt, C; Seeger, W; Weissmann, N | 1 |
| Brás-Silva, C; Correia-Pinto, J; Faria, B; Henriques-Coelho, T; Leite-Moreira, AF; Lourenço, AP; Roncon-Albuquerque, R; Wieland, J | 1 |
| Hatano, M; Kinugawa, K; Kohmoto, O; Nagai, R; Takahashi, T; Usui, S; Yao, A | 1 |
| Minami, S; Miyazaki, H; Mochizuki, S; Ohsawa, S; Okazaki, F; Onodera, T | 1 |
| Berger, RM; du Marchie Sarvaas, GJ; Houwertjes, MC; Koster, J; Schoemaker, RG; van Albada, ME | 1 |
1 trial(s) available for monocrotaline and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium handling.
Topics: Animals; Arrhythmias, Cardiac; Benzhydryl Compounds; Calcium; Connexin 43; Disease Models, Animal; Fura-2; Glucose; Glucosides; Heart Failure; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Sodium; Ventricular Dysfunction, Right; Ventricular Remodeling | 2022 |
73 other study(ies) available for monocrotaline and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
Right-sided heart failure is also associated with transverse tubule remodeling in the left ventricle.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Heart Failure; Heart Ventricles; Hypertrophy, Left Ventricular; Hypertrophy, Right Ventricular; Male; Membrane Proteins; Monocrotaline; Rats, Wistar; Ryanodine Receptor Calcium Release Channel; Sarcomeres; Ventricular Function, Left; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Phosphatidylinositol 3-Kinases; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Vascular Endothelial Growth Factor A; Ventricular Remodeling | 2022 |
Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension.
Topics: Animals; Fluvoxamine; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Right; Ventricular Remodeling | 2022 |
Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Arginine Vasopressin; Cysteine; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Hepatocyte Growth Factor; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Malondialdehyde; Melatonin; Monocrotaline; NF-E2-Related Factor 2; Proto-Oncogene Proteins; Pulmonary Arterial Hypertension; Rats; RNA, Small Interfering; Ventricular Remodeling | 2022 |
Upregulation of miR-335-5p Contributes to Right Ventricular Remodeling via Calumenin in Pulmonary Arterial Hypertension.
Topics: Angiotensin II; Animals; Antagomirs; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Mice; MicroRNAs; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Up-Regulation; Ventricular Remodeling | 2022 |
Cardioprotective Effect of Resistance Exercise on Left Ventricular Remodeling Associated with Monocrotaline-Induced Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Resistance Training; Vascular Remodeling; Ventricular Remodeling | 2022 |
Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling.
Topics: Animals; beta Catenin; Catenins; Disease Models, Animal; Heart Failure; Mice; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Signal Transduction; Ventricular Function, Right; Ventricular Remodeling | 2023 |
Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension.
Topics: 4-Butyrolactone; Animals; Animals, Newborn; Cells, Cultured; Fatty Acid Synthase, Type I; Gene Expression Regulation, Enzymologic; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Ventricular Remodeling | 2019 |
miR-181a/b-5p ameliorates inflammatory response in monocrotaline-induced pulmonary arterial hypertension by targeting endocan.
Topics: Animals; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Inflammation; MicroRNAs; Monocrotaline; Proteoglycans; Pulmonary Arterial Hypertension; Rats; Tumor Necrosis Factor-alpha; Ventricular Remodeling | 2020 |
Ursolic Acid Improves Monocrotaline-Induced Right Ventricular Remodeling by Regulating Metabolism.
Topics: Animals; Apoptosis; Carnitine O-Palmitoyltransferase; Cells, Cultured; Disease Models, Animal; Energy Metabolism; Fatty Acids; Fibrosis; Heart Ventricles; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Cardiac; PPAR alpha; Pulmonary Arterial Hypertension; Rats, Sprague-Dawley; Triterpenes; Ursolic Acid; Ventricular Function, Right; Ventricular Remodeling | 2020 |
TRPM4 Modulates Right Ventricular Remodeling Under Pressure Load Accompanied With Decreased Expression Level.
Topics: Animals; Child; Heart Failure; Humans; Hypertrophy, Right Ventricular; Mice; Monocrotaline; Rats; Rats, Wistar; TRPM Cation Channels; Ventricular Function, Right; Ventricular Remodeling | 2020 |
Chrysin Alleviates Monocrotaline-Induced Pulmonary Hypertension in Rats Through Regulation of Intracellular Calcium Homeostasis in Pulmonary Arterial Smooth Muscle Cells.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Calcium Signaling; Disease Models, Animal; Flavonoids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Muscle, Smooth, Vascular; Pulmonary Artery; Rats, Sprague-Dawley; TRPC Cation Channels; Vascular Remodeling; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2020 |
Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.
Topics: Animals; Cell Proliferation; Eicosapentaenoic Acid; Endothelial Cells; Endothelium, Vascular; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-6; Male; Mesoderm; Monocrotaline; Myocardial Contraction; Myocytes, Smooth Muscle; Phosphorylation; Proto-Oncogene Proteins c-fyn; Pulmonary Artery; Rats, Sprague-Dawley; src-Family Kinases; STAT3 Transcription Factor; Survival Analysis; Transforming Growth Factor beta2; Vasodilation; Ventricular Remodeling | 2020 |
Decreased Expression of Canstatin in Rat Model of Monocrotaline-Induced Pulmonary Arterial Hypertension: Protective Effect of Canstatin on Right Ventricular Remodeling.
Topics: Animals; Body Weight; Cardiotonic Agents; Collagen Type IV; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Kidney; Lung; Male; Monocrotaline; Organ Size; Peptide Fragments; Rats; Rats, Wistar; Recombinant Proteins; Ventricular Remodeling | 2020 |
Transplantation of viable mitochondria improves right ventricular performance and pulmonary artery remodeling in rats with pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Mitochondria; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Vascular Remodeling; Ventricular Remodeling | 2022 |
Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography.
Topics: Animals; Antihypertensive Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Monocrotaline; Predictive Value of Tests; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Synchrotrons; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Heart Failure; Heart Ventricles; Humans; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; RNA-Seq; Transcriptome; Ventricular Dysfunction, Right; Ventricular Remodeling | 2021 |
Soluble guanylate cyclase stimulator, trans-4-methoxy-β-nitrostyrene, has a beneficial effect in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Arterioles; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Signal Transduction; Soluble Guanylyl Cyclase; Styrenes; Vascular Remodeling; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Safflower injection inhibits pulmonary arterial remodeling in a monocrotaline-induced pulmonary arterial hypertension rat model.
Topics: Animals; Blood Pressure; Carthamus tinctorius; Cell Proliferation; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fibronectins; Injections; Integrins; Lung; Male; Monocrotaline; Myocardium; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Ventricular Remodeling | 2021 |
Sildenafil improves right ventricular remodelling in monocrotaline-induced rats by decreasing myocardial apoptosis and activating peroxisome proliferator-activated receptors.
Topics: Animals; Apoptosis; Disease Models, Animal; Heart Ventricles; In Situ Nick-End Labeling; Monocrotaline; Myocardium; Peroxisome Proliferator-Activated Receptors; Phosphodiesterase 5 Inhibitors; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Ventricular Remodeling | 2021 |
Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure.
Topics: Animals; Chronic Disease; Disease Models, Animal; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Male; Monocrotaline; Rats; Rats, Wistar; Ventricular Remodeling | 2021 |
Altered mTOR and Beclin-1 mediated autophagic activation during right ventricular remodeling in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Autophagy; Beclin-1; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases; Ventricular Dysfunction, Right; Ventricular Remodeling | 2017 |
Galectin-3 mediates the pulmonary arterial hypertension-induced right ventricular remodeling through interacting with NADPH oxidase 4.
Topics: Adult; Animals; Biomarkers; Collagen Type III; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Galectin 3; Gene Knockdown Techniques; Heart Ventricles; Humans; Hypertension, Pulmonary; Male; Middle Aged; Monocrotaline; Myocardium; Myofibroblasts; NADPH Oxidase 4; Oxidative Stress; Primary Cell Culture; Rats; Transforming Growth Factor beta1; Up-Regulation; Ventricular Remodeling; Young Adult | 2017 |
Effects of ovariectomy on antioxidant defence systems in the right ventricle of female rats with pulmonary arterial hypertension induced by monocrotaline.
Topics: Adaptation, Physiological; Animals; Antioxidants; Female; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Monocrotaline; Ovariectomy; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rats, Wistar; Ventricular Remodeling | 2018 |
Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Indoles; Male; Monocrotaline; Nestin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pulmonary Artery; Pyrroles; Rats, Wistar; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Osthole attenuates right ventricular remodeling via decreased myocardial apoptosis and inflammation in monocrotaline-induced rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blood Pressure; Caspase 3; Coumarins; Gene Expression Regulation; Heart Ventricles; I-kappa B Proteins; Interleukin-6; Male; Monocrotaline; Myocardium; Phosphorylation; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Ventricular Remodeling | 2018 |
Stage‑dependent changes of β2‑adrenergic receptor signaling in right ventricular remodeling in monocrotaline‑induced pulmonary arterial hypertension.
Topics: Animals; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Rats, Wistar; Receptors, Adrenergic, beta-2; Signal Transduction; Ventricular Dysfunction, Right; Ventricular Remodeling | 2018 |
Dipeptidyl peptidase IV (DPP-4) inhibition alleviates pulmonary arterial remodeling in experimental pulmonary hypertension.
Topics: Animals; Becaplermin; Bleomycin; Cell Movement; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Hypertension, Pulmonary; Lung; Male; MAP Kinase Signaling System; Monocrotaline; Myocytes, Smooth Muscle; PTEN Phosphohydrolase; Random Allocation; Rats, Wistar; Sitagliptin Phosphate; Tunica Intima; Vascular Remodeling; Ventricular Remodeling | 2018 |
Cardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Estrogens; Exercise Tolerance; Female; Hypertension, Pulmonary; Monocrotaline; Muscle, Skeletal; Ovariectomy; Pulmonary Artery; Rats; Receptors, G-Protein-Coupled; Ventricular Dysfunction; Ventricular Remodeling | 2018 |
Effects of toceranib compared with sorafenib on monocrotaline-induced pulmonary arterial hypertension and cardiopulmonary remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Autophagy; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Monocrotaline; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pulmonary Artery; Pyrroles; Rats, Wistar; Signal Transduction; Sorafenib; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Disease Models, Animal; Fabaceae; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; JNK Mitogen-Activated Protein Kinases; Male; Monocrotaline; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Plant Oils; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Signal Transduction; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2018 |
17β-estradiol preserves right ventricular function in rats with pulmonary arterial hypertension: an echocardiographic and histochemical study.
Topics: Animals; Biomarkers; Disease Models, Animal; Echocardiography; Estradiol; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Natriuretic Peptide, Brain; Rats, Sprague-Dawley; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2019 |
Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imines; Male; Mice, Knockout; Monocrotaline; Pulmonary Artery; Pyridines; Rats, Sprague-Dawley; Receptor, PAR-1; Thrombin; Vascular Remodeling; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Exploration of the Notch3-HES5 signal pathway in monocrotaline-induced pulmonary hypertension using rat model.
Topics: Animals; Arterial Pressure; Arterioles; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats, Sprague-Dawley; Receptor, Notch3; Repressor Proteins; Signal Transduction; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2019 |
Effect of estrogen on right ventricular remodeling of monocrotaline-induced pulmonary arterial hypertension in rats and its mechanism.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Heart Ventricles; Injections, Subcutaneous; Male; Monocrotaline; Pulmonary Arterial Hypertension; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2019 |
Right ventricular electrical remodeling and arrhythmogenic substrate in rat pulmonary hypertension.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Collagen Type I; Connexin 43; Death, Sudden, Cardiac; Drug Therapy, Combination; Epoprostenol; Gene Expression Regulation; Heart; Humans; Hypertension, Pulmonary; Male; Monocrotaline; Organ Culture Techniques; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Ventricular Dysfunction, Right; Ventricular Remodeling; Voltage-Sensitive Dye Imaging | 2013 |
Targeted delivery of pulmonary arterial endothelial cells overexpressing interleukin-8 receptors attenuates monocrotaline-induced pulmonary vascular remodeling.
Topics: Adenoviridae; Animals; Arterial Pressure; Cells, Cultured; Chemokine CCL2; Chemokines, CXC; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Female; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages; Monocrotaline; Neutrophil Infiltration; Neutrophils; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovariectomy; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-8; Transduction, Genetic; Up-Regulation; Ventricular Function, Right; Ventricular Remodeling | 2014 |
Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline.
Topics: Animals; Arrhythmias, Cardiac; Elastic Modulus; Excitation Contraction Coupling; Heart Conduction System; Hypertension, Pulmonary; Ion Channel Gating; Ion Channels; Mechanotransduction, Cellular; Monocrotaline; Physical Stimulation; Rats; Rats, Wistar; Stress, Mechanical; Systems Biology; Ventricular Dysfunction, Right; Ventricular Remodeling | 2014 |
Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension.
Topics: Acetanilides; Animals; Calcium Signaling; Collagen; Disease Models, Animal; Fibrosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Membrane Potentials; Monocrotaline; Myocytes, Cardiac; Myosin Heavy Chains; Piperazines; Pulmonary Artery; Ranolazine; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Sodium Channels; Time Factors; Vascular Remodeling; Vascular Resistance; Ventricular Function, Right; Ventricular Remodeling | 2014 |
[Early treatment with hepatocyte growth factor improves pulmonary artery and right ventricular remodeling in rats with pulmonary artery hypertension by modulating cytokines expression].
Topics: Adenoviridae; Animals; Blood Pressure; Cytokines; Disease Models, Animal; Heart Ventricles; Hepatocyte Growth Factor; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Transfection; Ventricular Remodeling | 2014 |
Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imidazoles; Lung; Male; Monocrotaline; Myocardium; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pulmonary Fibrosis; Pyridines; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Signal Transduction; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2015 |
[Effects of rutaecarpine on right ventriclar remodeling in rats with monocrotaline-induced pulmonary hypertension].
Topics: Animals; Antioxidants; Heart Ventricles; Hypertension, Pulmonary; Indole Alkaloids; Male; Malondialdehyde; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Quinazolines; Rats; Ventricular Remodeling | 2014 |
Aerobic Exercise Promotes a Decrease in Right Ventricle Apoptotic Proteins in Experimental Cor Pulmonale.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Disease Models, Animal; Echocardiography; Hemodynamics; Hydrogen Peroxide; Hypertrophy, Right Ventricular; Male; Monocrotaline; Physical Conditioning, Animal; Pulmonary Artery; Pulmonary Heart Disease; Rats, Wistar; Vascular Resistance; Ventricular Function, Right; Ventricular Remodeling | 2015 |
Farnesoid-X-receptor expression in monocrotaline-induced pulmonary arterial hypertension and right heart failure.
Topics: Animals; Disease Models, Animal; Gene Expression; Heart Failure; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Monocrotaline; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Vascular Remodeling; Ventricular Remodeling | 2015 |
Cardioprotective effects of early and late aerobic exercise training in experimental pulmonary arterial hypertension.
Topics: Animals; Biomarkers; Exercise Tolerance; Hypertension, Pulmonary; Male; Monocrotaline; Physical Conditioning, Animal; Random Allocation; Rats, Wistar; Ventricular Function, Right; Ventricular Remodeling | 2015 |
Tetrandrine prevents monocrotaline-induced pulmonary arterial hypertension in rats through regulation of the protein expression of inducible nitric oxide synthase and cyclic guanosine monophosphate-dependent protein kinase type 1.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Benzylisoquinolines; Catalase; Cell Proliferation; Cyclic GMP-Dependent Protein Kinase Type I; Disease Models, Animal; Glutathione; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Oxidative Stress; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase; Time Factors; Vascular Remodeling; Ventricular Remodeling | 2016 |
Exercise preconditioning prevents MCT-induced right ventricle remodeling through the regulation of TNF superfamily cytokines.
Topics: Animals; Cytokines; Disease Models, Animal; Exercise Therapy; Male; Monocrotaline; Myocardium; Physical Exertion; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2016 |
Pioglitazone alleviates cardiac and vascular remodelling and improves survival in monocrotaline induced pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Macrophages, Alveolar; Male; Monocrotaline; Myocytes, Cardiac; Natriuretic Peptide, Brain; Osteopontin; Pioglitazone; PPAR gamma; Pulmonary Artery; Rats, Sprague-Dawley; Thiazolidinediones; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2016 |
[Effect of chrysin on expression of NOX4 and NF-κB in right ventricle of monocrotaline-induced pulmonary arterial hypertension of rats].
Topics: Animals; Blotting, Western; Collagen; Disease Models, Animal; Flavonoids; Heart Ventricles; Hypertension, Pulmonary; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Rats; Ventricular Remodeling | 2015 |
Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis.
Topics: Animals; Apoptosis; Arterial Pressure; Dichloroacetic Acid; Disease Models, Animal; Heart Ventricles; Hemodynamics; Male; Mitochondria; Monocrotaline; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2016 |
HMGB1 down-regulation mediates terameprocol vascular anti-proliferative effect in experimental pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Hemodynamics; HMGB1 Protein; Hypertension; Male; Masoprocol; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Interaction Maps; Proteomics; Pulmonary Artery; Rats, Wistar; Recovery of Function; Time Factors; Vascular Remodeling; Ventricular Function, Left; Ventricular Function, Right; Ventricular Remodeling | 2017 |
Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling.
Topics: Administration, Oral; Animals; Blood Pressure; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Fibrillar Collagens; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Natriuretic Peptides; Osteopontin; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Rats, Wistar; RNA, Messenger; Sildenafil Citrate; Stroke Volume; Sulfones; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Ventricular Pressure; Ventricular Remodeling | 2009 |
The remodeling of connexin in the hypertrophied right ventricular in pulmonary arterial hypertension and the effect of a dual ET receptor antagonist (bosentan).
Topics: Animals; Bosentan; Connexin 43; Disease Models, Animal; Endothelin Receptor Antagonists; Gap Junctions; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microscopy, Confocal; Microscopy, Electron; Monocrotaline; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Sulfonamides; Ventricular Remodeling | 2009 |
Pressure overload-induced right ventricular failure is associated with re-expression of myocardial tenascin-C and elevated plasma tenascin-C levels.
Topics: Animals; Blood Pressure; Gene Expression; Heart Failure; Heart Ventricles; Hypertrophy, Right Ventricular; Immunohistochemistry; Integrins; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocardium; Rats; Rats, Wistar; Tenascin; Time Factors; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2009 |
Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.
Topics: Animals; Arterioles; Cardiac Output; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Extracellular Matrix Proteins; Female; Heart Rate; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Lung; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocrotaline; Myocardial Contraction; Myocardium; Pulmonary Alveoli; Pulmonary Artery; Rats; Rats, Wistar; Recovery of Function; RNA, Messenger; Stroke Volume; Time Factors; Transplantation, Homologous; Vascular Endothelial Growth Factor A; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Pressure; Ventricular Remodeling | 2009 |
Effects of telmisartan on right ventricular remodeling induced by monocrotaline in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Body Weight; Echocardiography; Fibrosis; Histocytochemistry; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Myocardium; Organ Size; Rats; Rats, Wistar; Stroke Volume; Systole; Telmisartan; Transforming Growth Factor beta1; Ventricular Remodeling | 2009 |
Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure.
Topics: Animals; Antioxidants; Disease Models, Animal; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Organometallic Compounds; Rats; Rats, Wistar; Reactive Oxygen Species; Salicylates; Ventricular Dysfunction, Right; Ventricular Remodeling | 2010 |
Treatment of pulmonary arterial hypertension with circulating angiogenic cells.
Topics: Animals; Arteries; Cell Movement; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Kaplan-Meier Estimate; Monocrotaline; Rats; Rats, Nude; Stem Cell Transplantation; Stem Cells; Ventricular Remodeling | 2011 |
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats.
Topics: Animals; Cell Degranulation; Cromolyn Sodium; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Mast Cells; Monocrotaline; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Rats; Rats, Sprague-Dawley; Ventricular Function, Right; Ventricular Remodeling | 2011 |
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Disease Models, Animal; Echocardiography, Doppler; Endothelin A Receptor Antagonists; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoxazoles; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfones; Time Factors; Ventricular Function, Right; Ventricular Remodeling | 2011 |
Effects of everolimus in combination with sildenafil in monocrotaline-induced pulmonary hypertension in rats.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelin-1; Everolimus; Female; Hypertension, Pulmonary; Monocrotaline; Nitroprusside; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sirolimus; Sulfones; Vasoconstrictor Agents; Vasodilator Agents; Ventricular Dysfunction, Right; Ventricular Remodeling | 2012 |
Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.
Topics: Animals; Calcium; Disease Models, Animal; Excitation Contraction Coupling; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Microscopy, Confocal; Monocrotaline; Myocardial Contraction; Myocytes, Cardiac; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Treatment Outcome; Ventricular Dysfunction, Right; Ventricular Remodeling | 2012 |
Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline.
Topics: Animals; Blotting, Western; Cell Adhesion Molecules; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; I-kappa B Proteins; Inflammation; Male; Mice; Monocrotaline; Myocardium; NF-kappa B; NF-KappaB Inhibitor alpha; Poisons; Real-Time Polymerase Chain Reaction; RNA; Signal Transduction; Ventricular Remodeling | 2012 |
Effects of purple grape juice in the redox-sensitive modulation of right ventricular remodeling in a pulmonary arterial hypertension model.
Topics: Animals; Beverages; Caspase 3; Disease Models, Animal; Echocardiography; Familial Primary Pulmonary Hypertension; Hydrogen Peroxide; Hypertension, Pulmonary; Lipid Peroxidation; Male; Monocrotaline; Oxidation-Reduction; Rats; Rats, Wistar; Signal Transduction; Thioredoxins; Ventricular Remodeling; Vitis | 2012 |
Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension.
Topics: ADAM Proteins; ADAM17 Protein; Angiotensin II; Animals; Cells, Cultured; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Extracellular Matrix; Female; Fibroblasts; Hypertension, Pulmonary; Male; Membrane Proteins; Monocrotaline; Nitriles; Osteopontin; Phenols; Propionates; Pyrazoles; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Ventricular Remodeling | 2012 |
Longitudinal in vivo SPECT/CT imaging reveals morphological changes and cardiopulmonary apoptosis in a rodent model of pulmonary arterial hypertension.
Topics: Animals; Annexins; Apoptosis; Blood Pressure; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Heart Ventricles; Humans; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Myocardium; Perfusion; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Systole; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Ventricular Remodeling | 2012 |
Effects of exercise on monocrotaline-induced changes in right heart function and pulmonary artery remodeling in rats.
Topics: Animals; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart Ventricles; Hemodynamics; Male; Monocrotaline; Physical Conditioning, Animal; Pulmonary Artery; Rats; Rats, Wistar; Ventricular Function, Right; Ventricular Remodeling | 2013 |
Estrogen and enalapril attenuate the development of right ventricular hypertrophy induced by monocrotaline in ovariectomized rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Body Weight; Densitometry; Disease Progression; Enalapril; Endothelin-1; Estrogens; Female; Hypertrophy, Right Ventricular; Male; Microscopy, Electron; Monocrotaline; Ovariectomy; Rats; Rats, Sprague-Dawley; Renin; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Sex Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ventricular Remodeling | 2003 |
Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Therapy, Combination; Gelatinases; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Iloprost; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Muscle, Smooth, Vascular; Naphthyridines; Oxygen; Phosphodiesterase Inhibitors; Pulmonary Artery; Pulmonary Gas Exchange; Pulmonary Heart Disease; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Ventricular Remodeling | 2004 |
Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats.
Topics: Angiotensinogen; Animals; Antihypertensive Agents; Bosentan; Cytochrome P-450 CYP11B2; Endothelin-1; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Myocardial Contraction; Natriuretic Peptide, Brain; Neurotransmitter Agents; Peptides, Cyclic; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Ventricular Function; Ventricular Remodeling | 2006 |
Upregulated neurohumoral factors are associated with left ventricular remodeling and poor prognosis in rats with monocrotaline-induced pulmonary arterial hypertension.
Topics: Angiotensin II; Animals; Hypertension, Pulmonary; Hypertrophy, Left Ventricular; Male; Monocrotaline; Natriuretic Peptide, Brain; Norepinephrine; Prognosis; Rats; Rats, Wistar; Up-Regulation; Ventricular Remodeling | 2006 |
Myocyte morphological characteristics differ between the phases of pulmonary hypertension-induced ventricular hypertrophy and failure.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Disease Progression; Heart Failure; Hypertension, Pulmonary; Male; Monocrotaline; Muscle Cells; Myocardium; Prognosis; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Ventricular Pressure; Ventricular Remodeling | 2006 |
Effects of erythropoietin on advanced pulmonary vascular remodelling.
Topics: Animals; Erythropoietin; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Male; Monocrotaline; Neovascularization, Pathologic; Pulmonary Circulation; Rats; Rats, Wistar; Stem Cells; Time Factors; Vascular Endothelial Growth Factor A; Ventricular Remodeling | 2008 |