monensin and Leprosy

monensin has been researched along with Leprosy* in 2 studies

Other Studies

2 other study(ies) available for monensin and Leprosy

Article	Year
Inhibition of apoptosis by ionomycin and zinc in peripheral blood mononuclear cells (PBMC) of leprosy patients. Clinical and experimental immunology, 1999, Volume: 117, Issue:1 PBMC from tuberculoid (BT/TT) and lepromatous leprosy (BL/LL) leprosy patients showed spontaneous apoptosis when cultured in the absence of mitogen for 24 h, which was inhibited by anti-tumour necrosis factor-alpha (TNF-alpha) antibodies. Apoptosis was also inhibited by ionomycin and zinc, which also increased IL-2 and decreased TNF-alpha production. The increase in IL-2 production suggests a mechanism whereby dietary supplements with zinc might alter the cell-mediated immunity response in leprosy patients. Topics: Antibodies; Apoptosis; Calcium Signaling; Cells, Cultured; Humans; Interleukin-2; Ionomycin; Leprosy; Leprosy, Lepromatous; Leprosy, Tuberculoid; Leukocytes, Mononuclear; Monensin; Tumor Necrosis Factor-alpha; Zinc	1999
Expression of mycobacterial antigens on murine dissociated Schwann cells infected with Mycobacterium leprae. Microbial pathogenesis, 1997, Volume: 22, Issue:3 Mycobacterial antigens were detected in a cell surface ELISA on murine dissociated Schwann cells infected with Mycobacterium leprae. The time kinetics of expression and its refractoriness to modulation with monensin suggests that the antigens are likely to be integrated into the membrane during bacterial entry. This may be partially responsible for the defective Schwann cell functions leading to subsequent peripheral nerve damage. Topics: Animals; Antibodies, Bacterial; Antifungal Agents; Antigens, Bacterial; Antimalarials; Cell Membrane; Chloroquine; Enzyme-Linked Immunosorbent Assay; Interferon-gamma; Kinetics; Leprosy; Mice; Monensin; Mycobacterium leprae; Recombinant Proteins; Schwann Cells	1997

Article

Year

Inhibition of apoptosis by ionomycin and zinc in peripheral blood mononuclear cells (PBMC) of leprosy patients.

Clinical and experimental immunology, 1999, Volume: 117, Issue:1

PBMC from tuberculoid (BT/TT) and lepromatous leprosy (BL/LL) leprosy patients showed spontaneous apoptosis when cultured in the absence of mitogen for 24 h, which was inhibited by anti-tumour necrosis factor-alpha (TNF-alpha) antibodies. Apoptosis was also inhibited by ionomycin and zinc, which also increased IL-2 and decreased TNF-alpha production. The increase in IL-2 production suggests a mechanism whereby dietary supplements with zinc might alter the cell-mediated immunity response in leprosy patients.

Topics: Antibodies; Apoptosis; Calcium Signaling; Cells, Cultured; Humans; Interleukin-2; Ionomycin; Leprosy; Leprosy, Lepromatous; Leprosy, Tuberculoid; Leukocytes, Mononuclear; Monensin; Tumor Necrosis Factor-alpha; Zinc

1999

Expression of mycobacterial antigens on murine dissociated Schwann cells infected with Mycobacterium leprae.

Microbial pathogenesis, 1997, Volume: 22, Issue:3

Mycobacterial antigens were detected in a cell surface ELISA on murine dissociated Schwann cells infected with Mycobacterium leprae. The time kinetics of expression and its refractoriness to modulation with monensin suggests that the antigens are likely to be integrated into the membrane during bacterial entry. This may be partially responsible for the defective Schwann cell functions leading to subsequent peripheral nerve damage.

Topics: Animals; Antibodies, Bacterial; Antifungal Agents; Antigens, Bacterial; Antimalarials; Cell Membrane; Chloroquine; Enzyme-Linked Immunosorbent Assay; Interferon-gamma; Kinetics; Leprosy; Mice; Monensin; Mycobacterium leprae; Recombinant Proteins; Schwann Cells

1997