momilactone-b and Colonic-Neoplasms

momilactone-b has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for momilactone-b and Colonic-Neoplasms

Article	Year
Cytotoxic and antitumor activity of momilactone B from rice hulls. Journal of agricultural and food chemistry, 2007, Mar-07, Volume: 55, Issue:5 The cytotoxic and antitumor activity of methanolic extract of rice hulls (MERH) were evaluated by the MTT-dye reduction assay against human colon cancer cells and the colonic aberrant crypt foci (ACF) assay in 1,2-dimethylhydrazine (DMH)-injected F344 male rats, respectively. MERH was found to be highly cytotoxic, with IC50 values of 0.5 microg/mL in vitro. Forty weeks of MERH supplementation (50 mg/kg of body weight/day) reduced colonic pre-neoplastic ACF formation by 35% (p < 0.01). An active compound, momilactone B, was isolated from MERH by silica gel chromatography, Sephadex LH-20 chromatography, and HPLC. The cytotoxic activity of momilactone B was evaluated by the MTT-dye reduction, lactate dehydrogenase (LDH), and colony-forming ability assays in human colon cancer HT-29 and SW620 cells. The results indicated that momilactone B from rice hulls might be a new candidate for chemotherapeutic agent against human colon cancer. Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Colonic Neoplasms; Diterpenes; HT29 Cells; Humans; Lactones; Male; Oryza; Precancerous Conditions; Rats; Rats, Inbred F344; Seeds	2007

Article

Year

Cytotoxic and antitumor activity of momilactone B from rice hulls.

Journal of agricultural and food chemistry, 2007, Mar-07, Volume: 55, Issue:5

The cytotoxic and antitumor activity of methanolic extract of rice hulls (MERH) were evaluated by the MTT-dye reduction assay against human colon cancer cells and the colonic aberrant crypt foci (ACF) assay in 1,2-dimethylhydrazine (DMH)-injected F344 male rats, respectively. MERH was found to be highly cytotoxic, with IC50 values of 0.5 microg/mL in vitro. Forty weeks of MERH supplementation (50 mg/kg of body weight/day) reduced colonic pre-neoplastic ACF formation by 35% (p < 0.01). An active compound, momilactone B, was isolated from MERH by silica gel chromatography, Sephadex LH-20 chromatography, and HPLC. The cytotoxic activity of momilactone B was evaluated by the MTT-dye reduction, lactate dehydrogenase (LDH), and colony-forming ability assays in human colon cancer HT-29 and SW620 cells. The results indicated that momilactone B from rice hulls might be a new candidate for chemotherapeutic agent against human colon cancer.

Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Colonic Neoplasms; Diterpenes; HT29 Cells; Humans; Lactones; Male; Oryza; Precancerous Conditions; Rats; Rats, Inbred F344; Seeds

2007