mometasone-furoate and Skin-Neoplasms

We report a rare case of a 14-year-old boy with Langerhans cell histiocytosis localized to the prepuce. The patient was treated with a topical corticosteroid followed by imiquimod cream resulting in significant clinical improvement of the lesion. Although spontaneous remission is possible, the use of imiquimod may be an effective alternative therapy in cases of cutaneous Langerhans cell histiocytosis refractory to topical corticosteroids.

Topics: Adolescent; Histiocytosis, Langerhans-Cell; Humans; Imiquimod; Male; Mometasone Furoate; Remission, Spontaneous; Skin Neoplasms

Inflammatory linear verrucous epidermal nevus (ILVEN) is a relatively rare disorder with an onset at early age, consisting of pruritic linear papules and/or plaques and histologic features resembling psoriasis or lichenoid dermatitis. The disease is a version of mosaicism caused by somatic mutations. ILVEN belongs to the heterogeneous group of congenital hamartomas of embryonal ectodermal origin, as a variant of verrucous epidermal nevus, representing approximately 5% of all epidermal nevi, with predominance in females and with general therapeutic resistance. We report on an 18-month-old female patient with ILVEN, who failed to respond to topical tacrolimus, but achieved complete resolution with topical application of momethasone furoate 0.1% under occlusion for 2 weeks, with no signs of recurrence to date. Consequent topical therapy can provide excellent results in young children.

Topics: Administration, Topical; Adrenal Cortex Hormones; Female; Humans; Infant; Mometasone Furoate; Nevus; Remission Induction; Skin Neoplasms

Primary cutaneous T-cell lymphomas mostly occur in patients of middle and higher age. Their rarity and an oftentimes atypical clinical presentation in childhood as well as the reluctance of taking biopsies in children are reasons for a delayed diagnosis. We report the case of an 11-year-old boy with a 7-year history of slowly progressive CD8+CD56+ mycosis fungoides of the cytotoxic immunophenotype. His trunk and extremities were affected by extensive pale-erythematous patches and plaques with fine scaling. In addition, several poikilodermatous lesions were present on his thighs. Improvement was achieved by topical mometasone furoate treatment. On the basis of our observation, a brief review on cutaneous T-cell lymphomas in childhood and on CD8+ subtypes in particular is given. Clinicopathological correlation is crucial for establishing the correct diagnosis and for estimation of the prognosis.

Topics: Biopsy; CD56 Antigen; CD8-Positive T-Lymphocytes; Child; Dermatologic Agents; Humans; Immunophenotyping; Lymphoma, T-Cell, Cutaneous; Male; Mometasone Furoate; Mycosis Fungoides; Skin Neoplasms; Ultrasonography

13-year-old girl presented with a 10-year history of multiple discrete red firm papules situated on her right upper arm. The histopathology examination revealed a massive subepidermal lymphohistiocytic infiltrate, consistent with acral pseudolymphomatous angiokeratoma of children. Treatment with topical application of mometasone furoate 0.1% cream once daily for 6 months improved the lesions partially. However, these papules returned to their pretreatment appearance and consistency within 6 months after the cessation of the topical corticosteroid. The authors prefer the term 'papular angiolymphoid hyperplasia' for this entity, based on the absence of histological angiokeratomatous features, the benign nature of the lesion and the previously reported cases from adults and non-acral sites.

Topics: Administration, Topical; Adolescent; Angiokeratoma; Anti-Inflammatory Agents; Arm; Female; Humans; Mometasone Furoate; Pregnadienediols; Pseudolymphoma; Skin Neoplasms; Treatment Outcome