mometasone-furoate and Hyperpigmentation

Topics: Aged; Anti-Inflammatory Agents; Dermatitis; Humans; Hyperpigmentation; Leprostatic Agents; Leprosy, Lepromatous; Male; Mometasone Furoate

Lichenoid drug eruption (LDE) is a common cutaneous side effect of drugs including antimalarials, antihypertensives, nonsteroids, anti-inflammatory drugs and diuretics. The physiopathologic relationship between colchicine treatment and LDE is unclear. There is very little documentation of LDE induced by colchicine in the literature. In this report, we present a case that developed LDE on the abdomen and the legs during the colchicine treatment.

Topics: Abdomen; Administration, Cutaneous; Administration, Oral; Colchicine; Drug Eruptions; Exanthema; Female; Histamine Antagonists; Humans; Hyperpigmentation; Leg; Lichenoid Eruptions; Middle Aged; Mometasone Furoate; Pruritus; Skin; Stomatitis, Aphthous

Serpentine erythematous or hyperpigmented streaks along the superficial venous network proximal to the site of injection may occur as a distinctive eruption after infusion of several chemotherapeutic agents. This morphological pattern has been described under various terms like, "persistent supravenous erythematous eruption," "persistent serpentine supravenous hyperpigmented eruption," or "persistent serpentine supravenous hyperpigmentation." These changes belong to the same clinical spectrum, which most often starts as erythematous serpentine streaks precisely located over the injected veins; the erythema is shortly replaced by hyperpigmentation. We report here a case of docetaxel-induced supravenous serpentine dermatitis with some interesting clinical and histological features.

Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Docetaxel; Drug Eruptions; Erythema; Female; Forearm; Humans; Hyperpigmentation; Injections, Intravenous; Middle Aged; Mometasone Furoate; Pregnadienediols; Pruritus; Taxoids; Veins

Dactinomycin (AMD) is an effective drug in the management of several malignant disorders and has been used for almost 40 years. Skin and subcutaneous toxicities following extravasation are well known and can be harmful. Similarly radiation-recall is a well established phenomenon following the administration of AMD. We report a patient who developed a localized brawny erythema in the crural folds and the axillae, likely due to AMD. This rare skin complication of AMD seems to benefit from topical corticosteroid treatment, although postinflammatory hyperpigmentation may take months to disappear.

Topics: Administration, Cutaneous; Adolescent; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Dactinomycin; Drug Eruptions; Erythema; Female; Glucocorticoids; Humans; Hyperpigmentation; Kidney Neoplasms; Mometasone Furoate; Pregnadienediols; Wilms Tumor