mometasone-furoate and Glaucoma

The purpose of this study was to investigate the association between long-term intranasal steroid use and intraocular pressure (IOP) elevation.. In total, 100 eyes from 50 patients on long-term intranasal steroids (>2 y) for allergic rhinitis and 90 eyes from 45 controls were included in this study. Patients on other forms of steroids and risk factors for glaucoma were excluded. IOP was measured and nonmydriatic stereoscopic optic disc photos were taken for each eye. The vertical cup-to-disc ratio and the status of the optic disc were evaluated.. The mean IOP for intranasal steroids group was significantly higher (15.24±2.31 mm Hg) compared to the control group (13.91±1.86 mm Hg; P=0.000). However, there were no significant differences in the vertical cup-to-disc ratio and the status of glaucomatous optic disc changes between the groups.. Prolonged use of intranasal steroids cause statistical significant increase in IOP in patients with allergic rhinitis although no significant glaucomatous disc changes were seen. We suggest patients on long-term use of intranasal steroid have a yearly eye examination to be monitored for IOP elevation and those with additional risk factors for glaucoma is closely monitored for glaucoma.

Topics: Administration, Intranasal; Adolescent; Adult; Androstadienes; Anti-Allergic Agents; Beclomethasone; Child; Cross-Sectional Studies; Female; Glaucoma; Glucocorticoids; Humans; Intraocular Pressure; Male; Mometasone Furoate; Optic Disk; Optic Nerve Diseases; Rhinitis, Allergic; Tonometry, Ocular; Young Adult

Raised intraocular pressure and glaucoma have rarely been associated with use of periorbital corticosteroids for dermatological conditions such as blepharitis and eczema. Three cases are described in which periorbital topical corticosteroids appear to have resulted in raised intraocular pressure or glaucoma. Topical corticosteroids used for dermatological conditions around the face and eyes are often regarded as being fairly innocuous with regard to ocular side-effects. This case series demonstrates that secondary open-angle glaucoma can be a sight-threatening consequence, and periorbital steroids should therefore be used cautiously and sparingly, particularly in those with a family history of glaucoma. Intraocular pressure may not always return to normal upon cessation of the drug.

Topics: Adult; Aged; Anti-Inflammatory Agents; Betamethasone; Blepharitis; Dermatitis, Allergic Contact; Eyelids; Glaucoma; Glucocorticoids; Humans; Hydrocortisone; Intraocular Pressure; Male; Middle Aged; Mometasone Furoate; Pregnadienediols; Psoriasis