mometasone-furoate and Constriction--Pathologic

Congenital midnasal stenosis (MNS) is an extremely rare disease which may be life threatening, and shows difficulty in diagnosis and management. This case series summarizes superiority of using intranasal mometasone furoate spray (IMS) and continuous positive airway pressure (CPAP) to treat nasal obstruction in neonates with MNS.. This study reviewed six consecutive cases of MNS.. Three patients were treated with IMS and CPAP. Two patients were treated with endoscopic balloon dilatation without stenting, followed by IMS and CPAP due to persisting nasal obstruction after the operation. One patient was treated with endoscopic balloon dilatation without stenting alone.. This study is the first to review the use of CPAP and IMS as an effective therapy for some patients with MNS. It suggests that conservative management with CPAP and IMS may be an alternative therapeutic option to surgery.

Topics: Administration, Intranasal; Anti-Inflammatory Agents; Conservative Treatment; Constriction, Pathologic; Continuous Positive Airway Pressure; Dilatation; Endoscopy; Female; Humans; Infant; Infant, Newborn; Male; Mometasone Furoate; Nasal Cavity; Nasal Obstruction; Nasal Sprays; Respiratory System Abnormalities

To describe a single institution's experience with the use of steroid-eluting stents after endoscopic transnasal repair of choanal atresia.. A case series with review of children who underwent choanal atresia repair at a tertiary children's hospital from June 2017 to January 2018 was performed. Those who had a mometasone drug-eluting stent (Propel. Five patients with a median age of 22 months at the time of repair met inclusion criteria. Two (40%) had bilateral atresia and 3 (60%) had confirmed CHARGE syndrome. A total of 6 mometasone drug-eluting stents were used in the 5 cases. Three patients were reassessed at least once in the OR; however, the majority (57.1%) of postoperative evaluations were able to be performed in the office or bedside setting. The first and last evaluations occurred a mean of 14 and 124 days after surgery, respectively. There were no instances of restenosis, repeat surgical interventions, or stent-related complications noted.. Placement of a mometasone drug-eluting stent is a promising method to improve postoperative results and management of choanal atresia repair by limiting the need for repeat anesthetics and OR procedures, as well as the complications of traditional stents.

Topics: Anti-Inflammatory Agents; CHARGE Syndrome; Child; Child, Preschool; Choanal Atresia; Constriction, Pathologic; Drug-Eluting Stents; Endoscopy; Female; Humans; Infant; Infant, Newborn; Male; Mometasone Furoate; Otorhinolaryngologic Surgical Procedures; Plastic Surgery Procedures; Postoperative Complications; Reoperation

Postintubation stenosis is a frequent complication of long-term endotracheal anesthesia. In the last few decades, its incidence showed an increasing tendency particularly among children and premature infants. It mostly affects the subglottic area and avoidance of a tracheotomy could lead to better life quality of the patient. We present the treatment of a glotto-subglottic stenosis in a 4-year-old girl. Ultra Dream Pulse Laser surgery was performed with mometason (Elocom) and mitomycin (Mitomycin-C) submucosal injections to prevent refibrosis. Minimally invasive operations play a key role in the treatment of laryngotracheal stenosis. Ultra Dream Pulse Laser surgeries could be safely applied in pediatric patients. Patient follow-up revealed wide glottis without any fibrosis. Ultra Dream Pulse Laser intervention completed with steroid-mitomycin infiltration is an efficient method of treating postintubation stenosis. Orv Hetil. 2019; 160(20): 792-796.. Absztrakt: A hosszan tartó intubatio gyakori szövődménye a postintubatiós stenosis, mely a leggyakrabban a subglotticus területen alakul ki. Az elmúlt évtizedek adatai szerint az incidencia emelkedő tendenciát mutat, különösen a kisgyermekek és a koraszülöttek körében. A terápia megválasztásakor fontos szempont a jó életminőség biztosítása, ezért ma már a tracheotomia elkerülésére törekszünk. Az alábbi esetünkben egy 4 éves kislány glottosubglotticus szűkületének ultrapulzációs lézerrel történő megoldását ismertetjük, melyet a refibrosis kialakulásának gátlása végett mometazon (Elocom) és mitomicin (Mitomycin-C) submucosus injektálásával egészítettünk ki. A légúti szűkületek megoldásában is egyre nagyobb szerepet játszanak a minimálinvazív beavatkozások, melyek gyermekeknél is biztonsággal végezhetők. Utánkövetésünk során a hangrés kellően tág, újabb hegesedés nem alakult ki. Tapasztalataink szerint a postintubatiós stenosis terápiájában a szteroid-mitomicin infiltrálással kiegészített ultrapulzációs lézeres hegoldás hatékony megoldást jelent. Orv Hetil. 2019; 160(20): 792–796.

Topics: Alkylating Agents; Anti-Inflammatory Agents; Child, Preschool; Combined Modality Therapy; Constriction, Pathologic; Female; Glottis; Humans; Laryngoscopy; Laryngostenosis; Laser Therapy; Mitomycin; Mometasone Furoate; Treatment Outcome