molsidomine has been researched along with Subarachnoid Hemorrhage in 6 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the authors examined the effects of treatment with the NO donor molsidomine with regard to decreasing the incidence of spasm-related delayed brain infarctions and improving clinical outcome in patients with SAH." | 7.83 | Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study. ( Brüning, R; Ehlert, A; Heindel, W; Hesselmann, V; Jacobs, AH; Manthei, G; Pluta, RM; Ringelstein, EB; Schmidt, C; Stummer, W; Wölfer, J, 2016) |
| " In this study, the authors examined the effects of treatment with the NO donor molsidomine with regard to decreasing the incidence of spasm-related delayed brain infarctions and improving clinical outcome in patients with SAH." | 3.83 | Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study. ( Brüning, R; Ehlert, A; Heindel, W; Hesselmann, V; Jacobs, AH; Manthei, G; Pluta, RM; Ringelstein, EB; Schmidt, C; Stummer, W; Wölfer, J, 2016) |
| "Within 48 hours, the patient developed cerebral vasospasm with DCI." | 2.53 | A Case of Hyperacute Onset of Vasospasm After Aneurysmal Subarachnoid Hemorrhage and Refractory Vasospasm Treated with Intravenous and Intraventricular Nitric Oxide: A Mini Review. ( Bein, B; Ehlert, A; Hesselmann, V; Manthei, G; Mathias, K; Pluta, R, 2016) |
| "Delayed cerebral ischemia (DCI) occurred only during loose, low-dose or interrupted treatment (17% vs." | 1.56 | Nitric Oxide-Based Treatment of Poor-Grade Patients After Severe Aneurysmal Subarachnoid Hemorrhage. ( Ehlert, A; Ehlert-Gamm, A; Flack, J; Gerss, J; Gessert, M; Hesselmann, V; Manthei, G; Starekova, J, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ehlert, A | 3 |
| Starekova, J | 1 |
| Manthei, G | 3 |
| Ehlert-Gamm, A | 1 |
| Flack, J | 1 |
| Gessert, M | 1 |
| Gerss, J | 1 |
| Hesselmann, V | 3 |
| Schmidt, C | 1 |
| Wölfer, J | 1 |
| Jacobs, AH | 1 |
| Brüning, R | 1 |
| Heindel, W | 1 |
| Ringelstein, EB | 1 |
| Stummer, W | 1 |
| Pluta, RM | 1 |
| Mathias, K | 1 |
| Bein, B | 1 |
| Pluta, R | 1 |
| Yamamoto, S | 2 |
| Nishizawa, S | 2 |
| Yokoyama, T | 2 |
| Ryu, H | 1 |
| Uemura, K | 2 |
| Onoue, H | 1 |
| Katusic, ZS | 1 |
1 review available for molsidomine and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
A Case of Hyperacute Onset of Vasospasm After Aneurysmal Subarachnoid Hemorrhage and Refractory Vasospasm Treated with Intravenous and Intraventricular Nitric Oxide: A Mini Review.
Topics: Aged; Female; Glasgow Coma Scale; Glasgow Outcome Scale; Humans; Injections, Intravenous; Injections | 2016 |
5 other studies available for molsidomine and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Nitric Oxide-Based Treatment of Poor-Grade Patients After Severe Aneurysmal Subarachnoid Hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Brain Ischemia; Feasibility Studies; Female; Hum | 2020 |
Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Infarction; Brain Ischemia; Drug Therapy, Combinat | 2016 |
Subarachnoid hemorrhage impairs cerebral blood flow response to nitric oxide but not to cyclic GMP in large cerebral arteries.
Topics: Animals; Brain; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Cyclic GMP; Injecti | 1997 |
Dysfunction of nitric oxide induces protein kinase C activation resulting in vasospasm after subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Cyclic GMP; Dogs; Enzyme Activation; Enzyme Inhibitors; Female; Immunoenzym | 1997 |
Subarachnoid hemorrhage and the role of potassium channels in relaxations of canine basilar artery to nitrovasodilators.
Topics: 4-Aminopyridine; Animals; Basilar Artery; Charybdotoxin; Cyclic GMP; Dogs; Female; Humans; Male; Mol | 1998 |