molsidomine has been researched along with Seizures in 1 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Molsidomine (25 mg kg(-1)), a donor of nitric oxide, commonly used in the treatment of coronary artery disease, enhanced the protective activity of valproate against the clonic phase of pentylenetetrazole-induced seizures in mice, significantly reducing the ED(50) of valproate from 123." | 7.71 | Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice. ( Arent, K; Kleinrok, Z; Tutka, P; Wielosz, M; Łuszczki, J, 2002) |
| "Molsidomine (25 mg kg(-1)), a donor of nitric oxide, commonly used in the treatment of coronary artery disease, enhanced the protective activity of valproate against the clonic phase of pentylenetetrazole-induced seizures in mice, significantly reducing the ED(50) of valproate from 123." | 3.71 | Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice. ( Arent, K; Kleinrok, Z; Tutka, P; Wielosz, M; Łuszczki, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tutka, P | 1 |
| Łuszczki, J | 1 |
| Kleinrok, Z | 1 |
| Arent, K | 1 |
| Wielosz, M | 1 |
1 other study available for molsidomine and Seizures
| Article | Year |
|---|---|
Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Convulsants; Drug Synergism; Male; Mice; Molsidomine; Pentylenetetrazole; | 2002 |