molsidomine has been researched along with Pregnancy in 20 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated whether a NO-donor, molsidomine, administered during NO synthase inhibition, could restore a normal pregnancy." | 3.69 | Lack of beneficial effects on the NO-donor, molsidomine, in the L-NAME-induced pre-eclamptic syndrome in pregnant rats. ( Boulanger, H; Es-Slami, S; Giudicelli, JF; Richer, C, 1996) |
| " These drugs must be administered parenterally and have a half-life of only a few minutes." | 2.40 | Clinical pharmacokinetics of vasodilators. Part II. ( Heintz, B; Kirsten, D; Kirsten, R; Nelson, K, 1998) |
| "Increased arginase expression in preeclampsia can induce uncoupling of NOS as a source of superoxide in the maternal vasculature in preeclampsia." | 1.36 | Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia. ( Davidge, ST; Sankaralingam, S; Xu, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (40.00) | 18.2507 |
| 2000's | 10 (50.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sankaralingam, S | 1 |
| Xu, H | 1 |
| Davidge, ST | 1 |
| Chiricozzi, E | 1 |
| Fernandez-Fernandez, S | 1 |
| Nardicchi, V | 1 |
| Almeida, A | 1 |
| Bolaños, JP | 1 |
| Goracci, G | 1 |
| Wei, P | 1 |
| Yuan, JX | 1 |
| Jin, X | 1 |
| Hu, ZY | 1 |
| Liu, YX | 1 |
| Khullar, S | 1 |
| Greenwood, SL | 1 |
| McCord, N | 1 |
| Glazier, JD | 1 |
| Ayuk, PT | 1 |
| Zhang, Y | 1 |
| Zhao, S | 1 |
| Gu, Y | 1 |
| Lewis, DF | 1 |
| Alexander, JS | 1 |
| Wang, Y | 1 |
| Jin, S | 1 |
| Kawanokuchi, J | 1 |
| Mizuno, T | 1 |
| Wang, J | 1 |
| Sonobe, Y | 1 |
| Takeuchi, H | 1 |
| Suzumura, A | 1 |
| Klockenbusch, W | 1 |
| Schrör, K | 1 |
| Hardy, E | 1 |
| Rubin, PC | 1 |
| Horn, EH | 1 |
| Boulanger, H | 2 |
| Boulanger, R | 1 |
| Colau, JC | 1 |
| Pruna, A | 1 |
| Richer, C | 1 |
| Es-Slami, S | 1 |
| Giudicelli, JF | 1 |
| Pasquier, JC | 1 |
| Kirsten, R | 1 |
| Nelson, K | 1 |
| Kirsten, D | 1 |
| Heintz, B | 1 |
| Okatani, Y | 1 |
| Wakatsuki, A | 1 |
| Morioka, N | 1 |
| Watanabe, K | 1 |
| Hill, IE | 1 |
| Murray, C | 1 |
| Richard, J | 1 |
| Rasquinha, I | 1 |
| MacManus, JP | 1 |
| Vedernikov, YP | 1 |
| Mayes, M | 1 |
| Moore, E | 1 |
| Gei, A | 1 |
| Saade, GR | 2 |
| Garfield, RE | 2 |
| Ota, H | 1 |
| Igarashi, S | 1 |
| Oyama, N | 1 |
| Suzuki, Y | 1 |
| Tanaka, T | 1 |
| Tiritilli, A | 1 |
| Fulep, E | 1 |
| Vedernikov, Y | 1 |
| Buxton, IL | 1 |
| Kaiser, RA | 1 |
| Malmquist, NA | 1 |
| Tichenor, S | 1 |
| McKoy, ML | 1 |
| Simon, OR | 1 |
1 review available for molsidomine and Pregnancy
| Article | Year |
|---|---|
Clinical pharmacokinetics of vasodilators. Part II.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Alprostadil; Amrinone; Carbazoles; Carvedilo | 1998 |
19 other studies available for molsidomine and Pregnancy
| Article | Year |
|---|---|
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Topics: Arginase; Arginine; Biopterins; Endothelial Cells; Female; Humans; Molsidomine; NADPH Oxidases; NF-k | 2010 |
Group IIA secretory phospholipase A2 (GIIA) mediates apoptotic death during NMDA receptor activation in rat primary cortical neurons.
Topics: Animals; Annexin A5; Apoptosis; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationshi | 2010 |
Molsidomine and N-omega-nitro-L-arginine methyl ester inhibit implantation and apoptosis in mouse endometrium.
Topics: Animals; Apoptosis; Embryo Implantation; Endometrium; Fas Ligand Protein; Female; Membrane Glycoprot | 2003 |
Nitric oxide and superoxide impair human placental amino acid uptake and increase Na+ permeability: implications for fetal growth.
Topics: Amino Acids; Biological Transport; Female; Fetal Growth Retardation; Free Radicals; Humans; Infant, | 2004 |
Effects of peroxynitrite and superoxide radicals on endothelial monolayer permeability: potential role of peroxynitrite in preeclampsia.
Topics: Cell Membrane Permeability; Cells, Cultured; Electric Impedance; Endothelium, Vascular; Female; Foca | 2005 |
Interferon-beta is neuroprotective against the toxicity induced by activated microglia.
Topics: Animals; Cells, Cultured; Coculture Techniques; Cytokines; Excitatory Amino Acid Agonists; Female; G | 2007 |
Prostacyclin contributes to nitroglycerin-mediated relaxation of human umbilical arteries.
Topics: Epoprostenol; Female; Humans; In Vitro Techniques; Indomethacin; Molsidomine; Muscle Relaxation; Mus | 1993 |
Effects of nitric oxide donors in vitro on the arachidonic acid-induced platelet release reaction and platelet cyclic GMP concentration in pre-eclampsia.
Topics: Adolescent; Adult; Blood Platelets; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; F | 1994 |
Improvement of a toxaemic pregnancy with molsidomine, a nitric oxide donor.
Topics: Adult; Female; Humans; Molsidomine; Nitric Oxide; Pre-Eclampsia; Pregnancy | 1996 |
Lack of beneficial effects on the NO-donor, molsidomine, in the L-NAME-induced pre-eclamptic syndrome in pregnant rats.
Topics: Animals; Blood Pressure; Body Weight; Enzyme Inhibitors; Female; Fetus; Heart; Heart Rate; Molsidomi | 1996 |
[Tocolytic effects of nitric oxide. Introduction to an experimental approach].
Topics: Animals; Drug Evaluation, Preclinical; Female; In Vitro Techniques; Molsidomine; Nitric Oxide; Nitri | 1997 |
Melatonin inhibits the vasorelaxant action of peroxynitrite in human umbilical artery.
Topics: Antioxidants; Female; Free Radical Scavengers; Humans; In Vitro Techniques; Melatonin; Molsidomine; | 1999 |
Despite the internucleosomal cleavage of DNA, reactive oxygen species do not produce other markers of apoptosis in cultured neurons.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Caspases; Cell Nucleus; Cholinesterase Inhibitors; Com | 2000 |
The effects of pregnancy and smooth muscle contractility on cervical distensibility in the rat.
Topics: Animals; Cervix Uteri; Compliance; Female; In Vitro Techniques; Labor, Obstetric; Molsidomine; Muscl | 2000 |
Optimal levels of nitric oxide are crucial for implantation in mice.
Topics: Animals; Decidua; Embryo Implantation; Endometrium; Enzyme Inhibitors; Female; Fetal Weight; Gestati | 1999 |
Guanylate cyclase and not ATP-dependent K(+) channels seems temperature-dependent in smooth muscle relaxation of human umbilical arteries.
Topics: Adenosine Triphosphate; Arginine; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; G | 2000 |
Contractility of late pregnant rat myometrium is refractory to activation of soluble but not particulate guanylate cyclase.
Topics: Animals; Atrial Natriuretic Factor; Dose-Response Relationship, Drug; Enzyme Activation; Female; Gua | 2001 |
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gu | 2001 |
The effects of SIN-1 on contractility and cyclic GMP levels in the pregnant mouse uterus.
Topics: Acetylcholine; Animals; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2001 |