molsidomine has been researched along with Pre-Eclampsia in 6 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated whether a NO-donor, molsidomine, administered during NO synthase inhibition, could restore a normal pregnancy." | 3.69 | Lack of beneficial effects on the NO-donor, molsidomine, in the L-NAME-induced pre-eclamptic syndrome in pregnant rats. ( Boulanger, H; Es-Slami, S; Giudicelli, JF; Richer, C, 1996) |
| "Increased arginase expression in preeclampsia can induce uncoupling of NOS as a source of superoxide in the maternal vasculature in preeclampsia." | 1.36 | Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia. ( Davidge, ST; Sankaralingam, S; Xu, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sankaralingam, S | 1 |
| Xu, H | 1 |
| Davidge, ST | 1 |
| Zhang, Y | 1 |
| Zhao, S | 1 |
| Gu, Y | 1 |
| Lewis, DF | 1 |
| Alexander, JS | 1 |
| Wang, Y | 1 |
| Hardy, E | 1 |
| Rubin, PC | 1 |
| Horn, EH | 1 |
| Boulanger, H | 2 |
| Boulanger, R | 1 |
| Colau, JC | 1 |
| Pruna, A | 1 |
| Richer, C | 1 |
| Es-Slami, S | 1 |
| Giudicelli, JF | 1 |
| Okatani, Y | 1 |
| Wakatsuki, A | 1 |
| Morioka, N | 1 |
| Watanabe, K | 1 |
6 other studies available for molsidomine and Pre-Eclampsia
| Article | Year |
|---|---|
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Topics: Arginase; Arginine; Biopterins; Endothelial Cells; Female; Humans; Molsidomine; NADPH Oxidases; NF-k | 2010 |
Effects of peroxynitrite and superoxide radicals on endothelial monolayer permeability: potential role of peroxynitrite in preeclampsia.
Topics: Cell Membrane Permeability; Cells, Cultured; Electric Impedance; Endothelium, Vascular; Female; Foca | 2005 |
Effects of nitric oxide donors in vitro on the arachidonic acid-induced platelet release reaction and platelet cyclic GMP concentration in pre-eclampsia.
Topics: Adolescent; Adult; Blood Platelets; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; F | 1994 |
Improvement of a toxaemic pregnancy with molsidomine, a nitric oxide donor.
Topics: Adult; Female; Humans; Molsidomine; Nitric Oxide; Pre-Eclampsia; Pregnancy | 1996 |
Lack of beneficial effects on the NO-donor, molsidomine, in the L-NAME-induced pre-eclamptic syndrome in pregnant rats.
Topics: Animals; Blood Pressure; Body Weight; Enzyme Inhibitors; Female; Fetus; Heart; Heart Rate; Molsidomi | 1996 |
Melatonin inhibits the vasorelaxant action of peroxynitrite in human umbilical artery.
Topics: Antioxidants; Female; Free Radical Scavengers; Humans; In Vitro Techniques; Melatonin; Molsidomine; | 1999 |