molsidomine has been researched along with Myocardial Ischemia in 23 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of myocardial ischemia (30 min) and reperfusion were measured in mice, with assays of myocardial apoptosis, superoxide production, NOx and nitrotyrosine content, and myocardial infarct size." | 3.73 | Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress. ( Christopher, TA; Coletti, C; Gao, E; Hu, A; Koch, W; Lopez, BL; Ma, XL; Tao, L; Wang, Y, 2006) |
| "We observed that N-nitro-L-arginine (NOLA), a nitric oxide biosynthesis inhibitor, exacerbated necrosis in the rabbit heart during ischemia-reperfusion while 3-morpholino-sydnonimine-hydrochloride (SIN-1) (a nitric oxide donor) reduced myocardial damage in the same model." | 3.69 | The opposing effects of an inhibitor of nitric oxide synthesis and of a donor of nitric oxide in rabbits undergoing myocardial ischemia reperfusion. ( Fung, KP; Wu, J; Wu, TW; Zeng, LH, 1994) |
| "The occurrence of sudden cardiac death (SCD) in patients with silent ischemia after myocardial infarction (MI) and the factors facilitating SCD are unknown." | 2.74 | Sudden cardiac death in patients with silent myocardial ischemia after myocardial infarction (from the Swiss Interventional Study on Silent Ischemia Type II [SWISSI II]). ( Abbate, A; Erne, P; Jamshidi, P; Kobza, R; Pfisterer, M; Schoenenberger, AW; Stuck, AE; Zuber, M, 2009) |
| " Up to 8 h after dosing in the morning, more marked and sustained effects were observed with the nitrate (ST at 2 h, -82%; p < 0." | 2.69 | Clinical comparison of antiischemic efficacy of isosorbide dinitrate and molsidomine. ( Beyerle, A; Lehmann, G; Reiniger, G; Schömig, A, 1998) |
| " For ID, tolerance after long-term intake manifested in 7 out of 18 patients, for M--in 5 out of 18." | 2.68 | [Molsidomine and isosorbide dinitrate: a comparative trial of tolerance in long-term intake by IHD patients with stable angina of effort]. ( Alimova, EV; Kutishenko, NP; Martsevich, SIu; Metelitsa, VI, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (73.91) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schoenenberger, AW | 2 |
| Kobza, R | 1 |
| Jamshidi, P | 1 |
| Zuber, M | 2 |
| Abbate, A | 1 |
| Stuck, AE | 1 |
| Pfisterer, M | 2 |
| Erne, P | 2 |
| Tao, L | 2 |
| Gao, E | 2 |
| Hu, A | 1 |
| Coletti, C | 1 |
| Wang, Y | 1 |
| Christopher, TA | 1 |
| Lopez, BL | 1 |
| Koch, W | 2 |
| Ma, XL | 2 |
| Jiao, X | 1 |
| Lau, WB | 1 |
| Yuan, Y | 1 |
| Lopez, B | 1 |
| Christopher, T | 1 |
| RamachandraRao, SP | 1 |
| Williams, W | 1 |
| Southan, G | 1 |
| Sharma, K | 1 |
| Burckhardt, D | 1 |
| Kiowski, W | 1 |
| Dubach, P | 1 |
| Resink, T | 1 |
| Körner, A | 1 |
| Ol'binskaia, LI | 2 |
| Sizova, ZhM | 2 |
| Morozov, IuA | 1 |
| Gryglewski, RJ | 1 |
| Swies, J | 1 |
| Chłopicki, S | 1 |
| Niezabitowski, P | 1 |
| Barnes, CS | 1 |
| Coker, SJ | 1 |
| Klaus, W | 1 |
| Alekperov, EE | 1 |
| Vacheron, A | 1 |
| de Vernejoul, P | 1 |
| Richard, V | 4 |
| Kaeffer, N | 3 |
| Tron, C | 2 |
| Thuillez, C | 4 |
| Fung, KP | 1 |
| Wu, TW | 1 |
| Zeng, LH | 1 |
| Wu, J | 1 |
| Kober, G | 1 |
| Bender, M | 1 |
| Vallbracht, C | 1 |
| Sievert, H | 1 |
| Klepzig, H | 1 |
| Blanc, T | 1 |
| François, A | 1 |
| Lallemand, F | 2 |
| Henry, JP | 2 |
| Czarnowska, E | 1 |
| Karwatowska-Prokopczuk, E | 1 |
| Runovich, AA | 1 |
| Verkhozin, IA | 1 |
| Kuril'skaia, TE | 1 |
| Zuev, AV | 1 |
| Lehmann, G | 1 |
| Reiniger, G | 1 |
| Beyerle, A | 1 |
| Schömig, A | 1 |
| Messin, R | 1 |
| Karpov, Y | 1 |
| Baikova, N | 1 |
| Bruhwyler, J | 1 |
| Monseu, MJ | 1 |
| Guns, C | 1 |
| Géczy, J | 1 |
| Alimova, EV | 1 |
| Martsevich, SIu | 1 |
| Kutishenko, NP | 1 |
| Metelitsa, VI | 1 |
| Marie, PY | 1 |
| Danchin, N | 1 |
| Branly, F | 1 |
| Angioï, M | 1 |
| Grentzinger, A | 1 |
| Virion, JM | 1 |
| Brouant, B | 1 |
| Olivier, P | 1 |
| Karcher, G | 1 |
| Juillière, Y | 1 |
| Zannad, F | 1 |
| Bertrand, A | 1 |
| Laude, K | 1 |
| Skvaril, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Single-blinded Placebo-controlled Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)[NCT02506062] | 21 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for molsidomine and Myocardial Ischemia
| Article | Year |
|---|---|
[Nitrates in cardiology practice].
Topics: Humans; Isosorbide Dinitrate; Molsidomine; Myocardial Ischemia; Nitroglycerin; Vasodilator Agents | 2000 |
6 trials available for molsidomine and Myocardial Ischemia
| Article | Year |
|---|---|
Sudden cardiac death in patients with silent myocardial ischemia after myocardial infarction (from the Swiss Interventional Study on Silent Ischemia Type II [SWISSI II]).
Topics: Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angioplasty, Balloon, Coronary; Antihypertensi | 2009 |
Effects of anti-ischaemic drug therapy in silent myocardial ischaemia type I: the Swiss Interventional Study on Silent Ischaemia type I (SWISSI I): a randomized, controlled pilot study.
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Bisoprolol; Death, Su | 2007 |
SIN-1 has no direct myocardial anti-ischemic action.
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease; Double-Blind Method; Electro | 1993 |
Clinical comparison of antiischemic efficacy of isosorbide dinitrate and molsidomine.
Topics: Blood Pressure; Coronary Disease; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Meth | 1998 |
Short- and long-term effects of molsidomine retard and molsidomine nonretard on exercise capacity and clinical status in patients with stable angina: a multicenter randomized double-blind crossover placebo-controlled trial.
Topics: Adult; Aged; Angina Pectoris; Death, Sudden; Double-Blind Method; Electrocardiography; Exercise Test | 1998 |
[Molsidomine and isosorbide dinitrate: a comparative trial of tolerance in long-term intake by IHD patients with stable angina of effort].
Topics: Adult; Aged; Angina Pectoris; Coronary Angiography; Cross-Over Studies; Double-Blind Method; Electro | 1997 |
16 other studies available for molsidomine and Myocardial Ischemia
| Article | Year |
|---|---|
Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress.
Topics: Animals; Apoptosis; Male; Mice; Molsidomine; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nit | 2006 |
Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis.
Topics: Amino Acid Substitution; Animals; Apoptosis; Cardiotonic Agents; Cyclic N-Oxides; Free Radical Scave | 2006 |
[The physicochemical properties of molsidomine preparations and their efficacy in treating IHD and circulatory failure].
Topics: Chemical Phenomena; Chemistry, Physical; Drug Evaluation; Female; Heart Failure; Hemodynamics; Human | 1995 |
Permissive effect of molsidomine towards cardioprotective action of iloprost in myocardial ischemia in cats.
Topics: Animals; Blood Pressure; Cats; Drug Synergism; Female; Heart Ventricles; Iloprost; Male; Molsidomine | 1993 |
Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaesthetized rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cyclic AMP; Cyclic GMP; Hemodynam | 1995 |
[Parenteral administration of molsidomine].
Topics: Coronary Circulation; Hemodynamics; Humans; Infusions, Intravenous; Molsidomine; Myocardial Ischemia | 1994 |
[The effect of molsidomine preparations on the coronary and myocardial reserves of patients with IHD complicated by circulatory failure].
Topics: Coronary Circulation; Drug Evaluation; Female; Heart; Heart Failure; Hemodynamics; Humans; Male; Mid | 1994 |
[Value of linsidomine (SIN 1) in the evaluation of myocardial viability by 201-Tl scintigraphy after exertion].
Topics: Adult; Aged; Aged, 80 and over; Exercise Test; Female; Heart; Humans; Injections, Intravenous; Male; | 1994 |
Ischemic preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion.
Topics: Acetylcholine; Animals; Arginine; Calcimycin; Coronary Vessels; Endothelium, Vascular; Male; Molsido | 1994 |
The opposing effects of an inhibitor of nitric oxide synthesis and of a donor of nitric oxide in rabbits undergoing myocardial ischemia reperfusion.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Heart; Molsidomine; Myocardial Ischemia; My | 1994 |
Myocardial and coronary endothelial protective effects of acetylcholine after myocardial ischaemia and reperfusion in rats: role of nitric oxide.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Coronary Vessels; Disease Models, Animal; Endothel | 1995 |
Preconditioning prevents chronic reperfusion-induced coronary endothelial dysfunction in rats.
Topics: Acetylcholine; Animals; Chronic Disease; Coronary Circulation; Coronary Vessels; Endothelium, Vascul | 1996 |
Role of oxygen free radicals in cardiocyte injury in the reperfused rat heart.
Topics: Animals; Endothelium; Free Radical Scavengers; Glycocalyx; Heart; Male; Molsidomine; Myocardial Isch | 1996 |
[The evaluation of the antianginal effect of Corvaton-Retard in patients with ischemic heart disease by using paired bicycle ergometry].
Topics: Delayed-Action Preparations; Drug Evaluation; Exercise Test; Humans; Male; Middle Aged; Molsidomine; | 1997 |
Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging: evidence of a protective effect of beta-blocking antianginal medications.
Topics: Adrenergic beta-Antagonists; Aged; Calcium Channel Blockers; Exercise Test; Female; Humans; Male; Mi | 1999 |
Evidence against a role of inducible nitric oxide synthase in the endothelial protective effects of delayed preconditioning.
Topics: Acetylcholine; Amidines; Animals; Benzylamines; Coronary Vessels; Endothelium, Vascular; Enzyme Inhi | 2000 |