molsidomine has been researched along with Muscle Contraction in 48 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effectiveness of organic nitrates in the therapy of angina pectoris can be explained from their direct relaxing action on vascular smooth muscle." | 4.76 | [Effect of nitrates, nitrate-like substances, calcium antagonists and beta-adrenergic receptor blockers on peripheral circulation]. ( Bassenge, E; Busse, R, 1982) |
| " However, the inhibition of the combined CPA and CCh response was reduced and the dose-response curve of SIN-1 shifted to the right." | 1.30 | Involvement of intracellular Ca2+ stores in inhibitory effects of NO donor SIN-1 and cGMP. ( Allescher, HD; Franck, H; Puschmann, A; Schusdziarra, V; Storr, M, 1998) |
| "The combination of hydralazine and nitrates has been shown to provide long-term benefit in congestive heart failure, despite a nitrate dosage that should induce tolerance." | 1.29 | Interaction between hydralazine and nitrovasodilators in vascular smooth muscle. ( Berkenboom, G; Fontaine, J; Unger, P, 1993) |
| " Nitroglycerin pre-exposure (10 microM for 30 min) provoked a significant shift to the right of the dose-response curve to nitroglycerin in aortae isolated from rats of 8 weeks, 12 and 18 months." | 1.29 | Nitrate tolerance and aging in isolated rat aorta. ( Berkenboom, G; Brékine, D; Fontaine, J; Unger, P, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (10.42) | 18.7374 |
| 1990's | 26 (54.17) | 18.2507 |
| 2000's | 16 (33.33) | 29.6817 |
| 2010's | 1 (2.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, M | 1 |
| Hashimoto, A | 1 |
| Gade, A | 1 |
| Akbarali, HI | 1 |
| Machtens, S | 1 |
| Ckert, S | 1 |
| Stief, CG | 2 |
| Tsikas, D | 1 |
| Frlich, Jr | 1 |
| Jonas, U | 2 |
| Takakura, K | 2 |
| Xiaohong, W | 2 |
| Takeuchi, K | 2 |
| Yasuda, Y | 1 |
| Fukuda, S | 2 |
| Tichenor, SD | 1 |
| Malmquist, NA | 2 |
| Buxton, IL | 2 |
| Strapkova, A | 1 |
| Antosova, M | 1 |
| Nosalova, G | 1 |
| Hashitani, H | 3 |
| Suzuki, H | 3 |
| Yanai, Y | 1 |
| Hayase, M | 1 |
| Sasaki, S | 1 |
| Kohri, K | 1 |
| Kohr, MJ | 1 |
| Wang, H | 1 |
| Wheeler, DG | 1 |
| Velayutham, M | 1 |
| Zweier, JL | 1 |
| Ziolo, MT | 2 |
| Busse, R | 1 |
| Bassenge, E | 1 |
| Rinaldi, G | 1 |
| Cingolani, H | 1 |
| Muramatsu, I | 1 |
| Fujii, K | 1 |
| Sakakibara, Y | 1 |
| Fujiwara, M | 1 |
| Höppner, CK | 1 |
| Mandrek, K | 1 |
| Noack, T | 1 |
| Golenhofen, K | 1 |
| Kienbaum, P | 1 |
| Braun, M | 1 |
| Hohlfeld, T | 1 |
| Weber, AA | 1 |
| Sarbia, M | 1 |
| Schrör, K | 2 |
| Bult, H | 2 |
| De Meyer, GR | 2 |
| Herman, AG | 2 |
| Unger, P | 2 |
| Berkenboom, G | 2 |
| Fontaine, J | 2 |
| Dufour, JF | 1 |
| Turner, TJ | 1 |
| Arias, IM | 1 |
| Brékine, D | 1 |
| Petkov, GV | 2 |
| Boev, KK | 2 |
| Canning, BJ | 1 |
| Undem, BJ | 1 |
| Karakousis, PC | 1 |
| Dey, RD | 1 |
| Potier, M | 1 |
| Winicki, J | 1 |
| Cambar, J | 1 |
| Matsumoto, T | 1 |
| Takahashi, M | 1 |
| Omura, T | 1 |
| Takaoka, A | 1 |
| Liu, Q | 1 |
| Nakae, I | 1 |
| Kinoshita, M | 1 |
| Cayabyab, FS | 1 |
| Jiménez, M | 2 |
| Vergara, P | 1 |
| deBruin, H | 1 |
| Daniel, EE | 1 |
| Kockx, MM | 1 |
| Kaeffer, N | 1 |
| Richard, V | 1 |
| Thuillez, C | 1 |
| Drescher, P | 1 |
| Madsen, PO | 1 |
| Persson, K | 2 |
| Alm, P | 1 |
| Uvelius, B | 1 |
| Andersson, KE | 3 |
| Franck, H | 1 |
| Storr, M | 1 |
| Puschmann, A | 1 |
| Schusdziarra, V | 1 |
| Allescher, HD | 1 |
| Zhang, XF | 1 |
| Komuro, T | 1 |
| Miwa, S | 1 |
| Minowa, T | 1 |
| Iwamuro, Y | 1 |
| Okamoto, Y | 1 |
| Ninomiya, H | 1 |
| Sawamura, T | 1 |
| Masaki, T | 1 |
| Silva, HM | 1 |
| Ambiel, CR | 1 |
| Alves-Do-Prado, W | 1 |
| Supinski, G | 1 |
| Stofan, D | 1 |
| Callahan, LA | 1 |
| Nethery, D | 1 |
| Nosek, TM | 1 |
| DiMarco, A | 1 |
| Vedernikov, YP | 1 |
| Mayes, M | 1 |
| Moore, E | 1 |
| Gei, A | 1 |
| Saade, GR | 1 |
| Garfield, RE | 1 |
| Petersson, J | 1 |
| Ryman, T | 1 |
| Högestätt, ED | 1 |
| Arbogast, S | 1 |
| Darques, JL | 1 |
| Bregeon, F | 1 |
| Jammes, Y | 1 |
| Alcón, S | 1 |
| Morales, S | 1 |
| Camello, PJ | 1 |
| Hemming, JM | 1 |
| Jennings, L | 1 |
| Mawe, GM | 1 |
| Pozo, MJ | 1 |
| Stojanovic, MO | 1 |
| Wahler, GM | 1 |
| Wolska, BM | 1 |
| Tanović, A | 1 |
| Fernández, E | 1 |
| Fukuta, H | 1 |
| Dickens, EJ | 1 |
| Tichenor, S | 1 |
| Klockenbusch, W | 1 |
| Braun, MS | 1 |
| Schröder, H | 1 |
| Heckenberger, RE | 1 |
| Strobach, H | 1 |
| Holmquist, F | 1 |
| Hedlund, H | 1 |
| Igawa, Y | 1 |
| Mattiasson, A | 1 |
| Yang, Z | 1 |
| Siebenmann, R | 1 |
| Studer, M | 1 |
| Egloff, L | 1 |
| Lüscher, TF | 1 |
| Bohn, H | 1 |
| Beyerle, R | 1 |
| Martorana, PA | 1 |
| Schönafinger, K | 1 |
| Maurice, DH | 1 |
| Crankshaw, D | 1 |
| Haslam, RJ | 1 |
| Astoin, M | 1 |
| Canton-Poincelot, B | 1 |
| Masson, A | 1 |
| Russo-Marie, F | 1 |
| Tsujibayashi, T | 1 |
| Niwa, A | 1 |
| Taniguchi, K | 1 |
| Takeuchi, J | 1 |
1 review available for molsidomine and Muscle Contraction
| Article | Year |
|---|---|
[Effect of nitrates, nitrate-like substances, calcium antagonists and beta-adrenergic receptor blockers on peripheral circulation].
Topics: Adrenergic beta-Antagonists; Amyl Nitrite; Angina Pectoris; Animals; Blood Circulation; Calcium Chan | 1982 |
47 other studies available for molsidomine and Muscle Contraction
| Article | Year |
|---|---|
Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex.
Topics: Animals; Calcium Chloride; CHO Cells; Cricetulus; Cysteine; Dose-Response Relationship, Drug; Ileum; | 2015 |
Effects of various nitric oxide-donating drugs on adrenergic tension of human seminal vesicles in vitro.
Topics: Adrenergic alpha-Agonists; Aged; Colforsin; Cyclic GMP; Ejaculation; Erectile Dysfunction; Humans; I | 2003 |
Deactivation of norepinephrine by peroxynitrite as a new pathogenesis in the hypotension of septic shock.
Topics: Anesthesia; Animals; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Hydrogen-Ion Concentrati | 2003 |
Dissociation of cGMP accumulation and relaxation in myometrial smooth muscle: effects of S-nitroso-N-acetylpenicillamine and 3-morpholinosyndonimine.
Topics: Animals; Calcium; Calcium Signaling; Cell Adhesion Molecules; Cyclic GMP; Dose-Response Relationship | 2003 |
Peroxynitrite decreases dopamine's vasoconstrictive activity.
Topics: Animals; Aorta, Thoracic; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; In Vitro | 2003 |
Interaction between nitric oxide and prostanoids in the respiratory system.
Topics: Animals; Bronchial Hyperreactivity; Cyclooxygenase Inhibitors; Diclofenac; Guinea Pigs; In Vitro Tec | 2006 |
Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ.
Topics: Adrenergic alpha-Agonists; Animals; Boron Compounds; Caffeine; Calcium Channel Blockers; Calcium Cha | 2007 |
Role of nitric oxide/cyclic GMP pathway in regulating spontaneous excitations in detrusor smooth muscle of the guinea-pig bladder.
Topics: Action Potentials; Animals; Calcium; Cyclic GMP; Electrophysiology; Female; Guinea Pigs; In Vitro Te | 2008 |
Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state.
Topics: Animals; Calcium-Binding Proteins; Mice; Mice, Knockout; Molsidomine; Muscle Contraction; Myocytes, | 2008 |
The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels.
Topics: Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Female; I | 1983 |
Vasorelaxing actions of molsidomine and its metabolites, in comparison with nitroglycerin.
Topics: Animals; Calcium; Dogs; Female; Male; Methemoglobin; Methylene Blue; Molsidomine; Muscle Contraction | 1983 |
Rabbit penile corpus cavernosum: electrical and mechanical activity of isolated strips.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Antiatherosclerotic effects of oral naftidrofuryl in cholesterol-fed rabbits involve inhibition of neutrophil function.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; C | 1995 |
Influence of chronic treatment with a nitric oxide donor on fatty streak development and reactivity of the rabbit aorta.
Topics: Acetylcholine; Animals; Aorta; Aortic Diseases; Arteriosclerosis; Body Weight; Cholesterol; Dietary | 1995 |
Interaction between hydralazine and nitrovasodilators in vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Drug Interactions; Drug Tolerance; Hydralazine; In Vitro Techniques; Isoni | 1993 |
Nitric oxide blocks bile canalicular contraction by inhibiting inositol trisphosphate-dependent calcium mobilization.
Topics: Animals; Bile Canaliculi; Calcium; Calcium Channel Blockers; Cyclic GMP; Inositol 1,4,5-Trisphosphat | 1995 |
Nitrate tolerance and aging in isolated rat aorta.
Topics: Aging; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniqu | 1993 |
The role of sarcoplasmic reticulum and sarcoplasmic reticulum Ca2+-ATPase in the smooth muscle tone of the cat gastric fundus.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Effects of organotypic culture on parasympathetic innervation of guinea pig trachealis.
Topics: Analysis of Variance; Animals; Atropine; Electric Stimulation; Enzyme Inhibitors; Esophagus; Guinea | 1996 |
Cyclopiazonic acid-induced changes in contractile activity of smooth muscle strips isolated from cat and guinea-pig stomach.
Topics: Acetylcholine; Animals; Calcium; Calcium-Transporting ATPases; Cats; Guinea Pigs; In Vitro Technique | 1996 |
Nitric oxide (NO) donor 3-morpholinosydnonimine antagonizes cyclosporin A-induced contraction in two in vitro glomerular models.
Topics: Animals; Cell Adhesion; Cell Size; Cells, Cultured; Cyclosporine; Enzyme Inhibitors; Glomerular Mesa | 1996 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Fem | 1997 |
Influence of nitric oxide and vasoactive intestinal peptide on the spontaneous and triggered electrical and mechanical activities of the canine ileum.
Topics: Animals; Calcium Channel Blockers; Dogs; Electrophysiology; Enzyme Inhibitors; Female; Ileum; Male; | 1997 |
The effect of chronic treatment with NO donors during intimal thickening and fatty streak formation.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Carotid Arteries; Cholesterol; Cholesterol, Dietary; Diet, | 1997 |
Delayed coronary endothelial protection 24 hours after preconditioning: role of free radicals.
Topics: Acetylcholine; Animals; Coronary Vessels; Endothelium, Vascular; Free Radical Scavengers; In Vitro T | 1997 |
Attenuation of contrast material-induced renal artery vasoconstriction by nitric oxide donors.
Topics: Animals; Contrast Media; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Enzym | 1997 |
Nitrergic and cholinergic innervation of the rat lower urinary tract after pelvic ganglionectomy.
Topics: Acetylcholine; Animals; Carbachol; Cyclic GMP; Electric Stimulation; Female; Ganglia; Ganglionectomy | 1998 |
Involvement of intracellular Ca2+ stores in inhibitory effects of NO donor SIN-1 and cGMP.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1998 |
Role of nonselective cation channels as Ca2+ entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide.
Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Endothelin-1; Imidazoles; In Vitro Techniques; Io | 1998 |
The neuromuscular transmission fade (Wedensky inhibition) induced by L-arginine in neuromuscular preparations from rats.
Topics: Animals; Arginine; Diaphragm; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; | 1999 |
Peroxynitrite induces contractile dysfunction and lipid peroxidation in the diaphragm.
Topics: Aldehydes; Animals; Calcium; Diaphragm; Kinetics; Lipid Peroxidation; Molsidomine; Muscle Contractio | 1999 |
The effects of pregnancy and smooth muscle contractility on cervical distensibility in the rat.
Topics: Animals; Cervix Uteri; Compliance; Female; In Vitro Techniques; Labor, Obstetric; Molsidomine; Muscl | 2000 |
Vasodilator effects of KRN2391, levcromakalim and 3-morpholino-sydnonimin in human pial and omental arteries.
Topics: Aged; Arteries; ATP-Binding Cassette Transporters; Cromakalim; Enzyme Inhibitors; Guanylate Cyclase; | 2000 |
Effects of endogenous nitric oxide in activation of group IV muscle afferents.
Topics: Animals; Blood Pressure; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Molsidomine; | 2001 |
A redox-based mechanism for the contractile and relaxing effects of NO in the guinea-pig gall bladder.
Topics: Acetylcholine; Animals; Arachidonic Acid; Atropine; Calcium; Gallbladder; Guinea Pigs; Male; Molsido | 2001 |
Anti-adrenergic effects of nitric oxide donor SIN-1 in rat cardiac myocytes.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium-Binding Proteins; Enzyme Inhibitors; Free Radica | 2001 |
Actions of NO donors and endogenous nitrergic transmitter on the longitudinal muscle of rat ileum in vitro: mechanisms involved.
Topics: Animals; Apamin; Atropine; Calcium Channels; Charybdotoxin; Dose-Response Relationship, Drug; Drug I | 2001 |
Cellular mechanisms of nitric oxide-induced relaxation of corporeal smooth muscle in the guinea-pig.
Topics: Animals; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Guinea Pigs; Intracell | 2002 |
Actions of S-nitroso N-acetyl penicillamine and 3-morpholinosydonimine may involve disparate signaling pathways in myometrial smooth muscle.
Topics: Animals; Blotting, Western; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-De | 2001 |
Prostacyclin rather than nitric oxide lowers human umbilical artery tone in vitro.
Topics: Arginine; Bradykinin; Cyclic GMP; Epoprostenol; Female; Histamine; Humans; Iloprost; In Vitro Techni | 1992 |
Characterization of inhibitory neurotransmission in the isolated corpus cavernosum from rabbit and man.
Topics: Animals; Arginine; Electric Stimulation; Humans; Male; Molsidomine; Muscle Contraction; Muscle Relax | 1992 |
Effects of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro.
Topics: Animals; Arginine; Electric Stimulation; Female; In Vitro Techniques; Molsidomine; Muscle Contractio | 1992 |
Similar endothelium-dependent relaxation, but enhanced contractility, of the right gastroepiploic artery as compared with the internal mammary artery.
Topics: Acetylcholine; Arteries; Coronary Artery Bypass; Endothelium, Vascular; Histamine; Humans; Mammary A | 1992 |
CAS 936, a novel syndnonimine with direct vasodilating and nitric oxide-donating properties: effects on isolated blood vessels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcimycin; Guinea Pigs | 1991 |
Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle.
Topics: Adenylyl Cyclases; Animals; Aorta; Dose-Response Relationship, Drug; Drug Synergism; In Vitro Techni | 1991 |
[Biological effects of SIN-1 in the vascular wall].
Topics: Animals; Endothelium; Epoprostenol; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Nitro | 1987 |
Hemodynamic effects of molsidomine on weight sustaining isometric exercise in patients with ischemic heart disease.
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Female; Heart Rate; Hemodynamics; Humans; Isometric C | 1985 |