molsidomine has been researched along with Innate Inflammatory Response in 10 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have investigated the immune-modulating effect of one of such drugs, molsidomine, able to slow the progression of muscular dystrophy in the α-Sarcoglican-null mice, a model for the limb girdle muscular dystrophy 2D, sharing several hallmarks of muscle degeneration with other muscular dystrophies." | 7.79 | The nitric oxide-donor molsidomine modulates the innate inflammatory response in a mouse model of muscular dystrophy. ( Brunelli, S; Campana, L; Clementi, E; Cottone, L; Querini, PR; Sciorati, C; Zordan, P, 2013) |
| "Pretreatment with molsidomine significantly reduced disease activity index, colon mass index, colonic macroscopic and histological damage." | 5.62 | Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis. ( El-Kashef, DH; Mohamed, NI; Suddek, GM, 2021) |
| " Nitric oxide (NO) donors are used to treat patients with stable angina pectoris, and the aim of this study was to investigate the short- and long-term effect of molsidomine on the level of this circulating biochemical marker of endothelial function." | 5.11 | Long-term treatment with the NO-donor molsidomine reduces circulating ICAM-1 levels in patients with stable angina. ( Carreer-Bruhwyler, F; Géczy, J; Herman, AG; Van Hove, C, 2005) |
| " We have investigated the immune-modulating effect of one of such drugs, molsidomine, able to slow the progression of muscular dystrophy in the α-Sarcoglican-null mice, a model for the limb girdle muscular dystrophy 2D, sharing several hallmarks of muscle degeneration with other muscular dystrophies." | 3.79 | The nitric oxide-donor molsidomine modulates the innate inflammatory response in a mouse model of muscular dystrophy. ( Brunelli, S; Campana, L; Clementi, E; Cottone, L; Querini, PR; Sciorati, C; Zordan, P, 2013) |
| " Since nitration of tyrosine residues occurs in a range of diseases involving inflammation, we tested the hypothesis that nitration of specific proteins could result in apoptosis of hepatic stellate cells (HSC), the primary cellular source of matrix components in liver diseases." | 3.77 | Apoptosis of hepatic stellate cells mediated by specific protein nitration. ( Domingo de Miguel, E; Iraburu, MJ; López-Zabalza, MJ; Mòdol, T; Natal, C; Pérez de Obanos, MP, 2011) |
| "Pretreatment with molsidomine significantly reduced disease activity index, colon mass index, colonic macroscopic and histological damage." | 1.62 | Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis. ( El-Kashef, DH; Mohamed, NI; Suddek, GM, 2021) |
| "Airway inflammation was monitored by bronchoalveolar lavage, three and seven days after administration." | 1.31 | Intra-luminal exposure of murine airways to peroxynitrite causes inflammation but not hyperresponsiveness. ( Folkerts, G; Habernickel, J; Muijsers, RB; Nijkamp, FP; Postma, DS; van der Veeken, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mohamed, NI | 1 |
| Suddek, GM | 1 |
| El-Kashef, DH | 1 |
| Zordan, P | 1 |
| Sciorati, C | 1 |
| Campana, L | 1 |
| Cottone, L | 1 |
| Clementi, E | 1 |
| Querini, PR | 1 |
| Brunelli, S | 1 |
| Kilic, T | 1 |
| Parlakpinar, H | 1 |
| Polat, A | 1 |
| Taslidere, E | 1 |
| Vardi, N | 1 |
| Sarihan, E | 1 |
| Ermis, H | 1 |
| Tanbag, K | 1 |
| González-Rodríguez, S | 1 |
| Hidalgo, A | 1 |
| Baamonde, A | 1 |
| Menéndez, L | 1 |
| Mòdol, T | 1 |
| Natal, C | 1 |
| Pérez de Obanos, MP | 1 |
| Domingo de Miguel, E | 1 |
| Iraburu, MJ | 1 |
| López-Zabalza, MJ | 1 |
| Savoye, G | 1 |
| Tamion, F | 1 |
| Richard, V | 1 |
| Varin, R | 1 |
| Thuillez, C | 1 |
| Van Hove, C | 1 |
| Carreer-Bruhwyler, F | 1 |
| Géczy, J | 1 |
| Herman, AG | 1 |
| Bar-Shai, M | 1 |
| Hasnis, E | 1 |
| Wiener-Megnazi, Z | 1 |
| Reznick, AZ | 1 |
| Muijsers, RB | 1 |
| van der Veeken, A | 1 |
| Habernickel, J | 1 |
| Folkerts, G | 1 |
| Postma, DS | 1 |
| Nijkamp, FP | 1 |
| Dembińska-Kieć, A | 1 |
| Zmuda, A | 1 |
| Marcinkiewicz, J | 1 |
| Sinzinger, H | 1 |
| Gryglewski, RJ | 1 |
1 trial available for molsidomine and Innate Inflammatory Response
| Article | Year |
|---|---|
Long-term treatment with the NO-donor molsidomine reduces circulating ICAM-1 levels in patients with stable angina.
Topics: Angina Pectoris; Drug Administration Schedule; Female; Humans; Inflammation; Intercellular Adhesion | 2005 |
9 other studies available for molsidomine and Innate Inflammatory Response
| Article | Year |
|---|---|
Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis.
Topics: Acetic Acid; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulator | 2021 |
The nitric oxide-donor molsidomine modulates the innate inflammatory response in a mouse model of muscular dystrophy.
Topics: Animals; Disease Models, Animal; Fibrosis; Humans; Immunity, Innate; Inflammation; Mice; Molsidomine | 2013 |
Protective and therapeutic effect of molsidomine on bleomycin-induced lung fibrosis in rats.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Bleomycin; Bronchoalveolar Lavage; Catalase; Fem | 2014 |
Spinal and peripheral mechanisms involved in the enhancement of morphine analgesia in acutely inflamed mice.
Topics: Acute Disease; Analgesia; Animals; Carrageenan; Glyburide; Inflammation; Injections, Spinal; Mice; M | 2010 |
Apoptosis of hepatic stellate cells mediated by specific protein nitration.
Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Cell Line; DNA Fragmentation; Hepatic Stellate Cells; Huma | 2011 |
Hemorrhagic shock resuscitation affects early and selective mesenteric artery endothelial function through a free radical-dependent mechanism.
Topics: Acetylcholine; Animals; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Fre | 2005 |
The role of reactive nitrogen species and cigarette smoke in activation of transcription factor NF-kappaB and implication to inflammatory processes.
Topics: Animals; Cell Line; Cells, Cultured; Humans; Inflammation; Lymphocytes; Molsidomine; NF-kappa B; Nic | 2006 |
Intra-luminal exposure of murine airways to peroxynitrite causes inflammation but not hyperresponsiveness.
Topics: Acetylcholine; Animals; Bronchi; Bronchial Hyperreactivity; Inflammation; Male; Methacholine Chlorid | 2002 |
Influence of no-donor (SIN-1) on functions of inflammatory cells.
Topics: Animals; Glucuronidase; Humans; Hybridomas; Inflammation; Interleukin-2; Leukocytes; Lipoproteins, L | 1991 |