molsidomine has been researched along with Injury, Ischemia-Reperfusion in 27 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In conclusion, these observations suggest that pre-treatment with nitric oxide donor molsidomine and PAF antagonist lexipafant before the reperfusion period may be useful in preventing hepatic reperfusion injury." | 7.72 | Effects of molsidomine and lexipafant in hepatic ischaemia--reperfusion injury. ( Al, B; Aldemir, M; Boşnak, M; Büyükbayram, H; Taçyildiz, I, 2004) |
| "Aim of this experimental study is to verify the protective effect of molsidomine on the renal function and structural modifications in the ischemia-reperfusion rat kidney." | 7.71 | The effects of the nitric oxide donor molsidomine prevent in warm ischemia-reperfusion injury of the rat renal--a functional and histophatological study. ( Aldemir, M; Büyükbayram, H; Dokucu, AI; Otçu, S; Oztürk, H, 2001) |
| "Previous studies have suggested reductions in lung reperfusion injury with pentoxifylline, inositol polyanions, and the nitric oxide donor, SIN-1, but these agents have never been directly compared to ascertain which is superior." | 7.70 | Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1. ( Clark, SC; Dark, JH; Flecknell, PA; Roughan, J; Sudarshan, C, 1999) |
| "Molsidomine plays a role in attenuating reperfusion injury of the small intestine by depression of tissue MDA levels and MIS and regulates post-ischemic intestinal perfusion while restoring the intestinal microcirculatory blood flow and histologic injury." | 5.32 | The nitric oxide donor molsidomine prevents ischemia/reperfusion injury of the adult rat small intestine. ( Aldemir, M; Dokucu, AI; Kilinç, N; Oztürk, H; Sahin, AH; Yağmur, Y, 2003) |
| "Molsidomine treatment almost completely prevented the I-R-induced renal dysfunction, and survival reached 100%." | 5.32 | Intrarenal administration of molsidomine, a molecule releasing nitric oxide, reduces renal ischemia-reperfusion injury in rats. ( Arevalo, M; Eleno, N; Garcia-Criado, FJ; Lopez-Novoa, JM; Rodriguez-Peña, A, 2004) |
| " The aim of our research was to compare molsidomine, SIN-1, SIN-1A, and lidocaine influence on arrhythmias and hemodynamic parameters in 2 experimental models in rats." | 3.85 | New approach to molsidomine active metabolites coming from the results of 2 models of experimental cardiology. ( Krzemiński, TF; Mitręga, KA; Porc, M; Żorniak, M, 2017) |
| "In conclusion, these observations suggest that pre-treatment with nitric oxide donor molsidomine and PAF antagonist lexipafant before the reperfusion period may be useful in preventing hepatic reperfusion injury." | 3.72 | Effects of molsidomine and lexipafant in hepatic ischaemia--reperfusion injury. ( Al, B; Aldemir, M; Boşnak, M; Büyükbayram, H; Taçyildiz, I, 2004) |
| "Aim of this experimental study is to verify the protective effect of molsidomine on the renal function and structural modifications in the ischemia-reperfusion rat kidney." | 3.71 | The effects of the nitric oxide donor molsidomine prevent in warm ischemia-reperfusion injury of the rat renal--a functional and histophatological study. ( Aldemir, M; Büyükbayram, H; Dokucu, AI; Otçu, S; Oztürk, H, 2001) |
| "Previous studies have suggested reductions in lung reperfusion injury with pentoxifylline, inositol polyanions, and the nitric oxide donor, SIN-1, but these agents have never been directly compared to ascertain which is superior." | 3.70 | Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1. ( Clark, SC; Dark, JH; Flecknell, PA; Roughan, J; Sudarshan, C, 1999) |
| "Molsidomine plays a role in attenuating reperfusion injury of the small intestine by depression of tissue MDA levels and MIS and regulates post-ischemic intestinal perfusion while restoring the intestinal microcirculatory blood flow and histologic injury." | 1.32 | The nitric oxide donor molsidomine prevents ischemia/reperfusion injury of the adult rat small intestine. ( Aldemir, M; Dokucu, AI; Kilinç, N; Oztürk, H; Sahin, AH; Yağmur, Y, 2003) |
| "Molsidomine treatment almost completely prevented the I-R-induced renal dysfunction, and survival reached 100%." | 1.32 | Intrarenal administration of molsidomine, a molecule releasing nitric oxide, reduces renal ischemia-reperfusion injury in rats. ( Arevalo, M; Eleno, N; Garcia-Criado, FJ; Lopez-Novoa, JM; Rodriguez-Peña, A, 2004) |
| "Ischemia-reperfusion injury causes tissue damage that leads to a decrease in bioavailability of nitric oxide." | 1.31 | The effects of the nitric oxide donor SIN-1 on ischemia-reperfused cutaneous and myocutaneous flaps. ( Kerrigan, CL; Khiabani, KT, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (33.33) | 18.2507 |
| 2000's | 16 (59.26) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Polat, N | 1 |
| Ozer, MA | 1 |
| Parlakpinar, H | 1 |
| Vardi, N | 1 |
| Aksungur, Z | 1 |
| Ozhan, O | 1 |
| Yildiz, A | 1 |
| Turkoz, Y | 1 |
| Żorniak, M | 1 |
| Mitręga, KA | 1 |
| Porc, M | 1 |
| Krzemiński, TF | 1 |
| Dokucu, AI | 3 |
| Ozturk, H | 5 |
| Tuncer, MC | 1 |
| Yilmaz, F | 1 |
| Ozturk, K | 1 |
| Ozyurt, H | 1 |
| Somay, A | 1 |
| Karaca, C | 1 |
| Aldemir, M | 3 |
| Yağmur, Y | 1 |
| Kilinç, N | 1 |
| Sahin, AH | 1 |
| Yokozawa, T | 1 |
| Rhyu, DY | 1 |
| Cho, EJ | 1 |
| Aoyagi, K | 1 |
| Müller, AR | 1 |
| Platz, KP | 2 |
| Häusler, M | 1 |
| Heckert, C | 1 |
| Lobeck, H | 1 |
| Neuhaus, P | 2 |
| Buyukbayram, H | 3 |
| Ozdemir, E | 1 |
| Ketani, A | 1 |
| Gurel, A | 1 |
| Onen, A | 1 |
| Otçu, S | 2 |
| Nielsen, VG | 1 |
| Crow, JP | 1 |
| Boşnak, M | 1 |
| Al, B | 1 |
| Taçyildiz, I | 1 |
| Rodriguez-Peña, A | 1 |
| Garcia-Criado, FJ | 2 |
| Eleno, N | 1 |
| Arevalo, M | 1 |
| Lopez-Novoa, JM | 2 |
| Savoye, G | 1 |
| Tamion, F | 1 |
| Richard, V | 1 |
| Varin, R | 1 |
| Thuillez, C | 1 |
| Chander, V | 1 |
| Chopra, K | 1 |
| Lozano, FS | 1 |
| Rodriguez, JM | 1 |
| Barros, MB | 1 |
| Nicolás, JL | 1 |
| Parreño, A | 1 |
| Revilla, J | 1 |
| Gómez-Alonso, A | 1 |
| Kaundal, RK | 1 |
| Shah, KK | 1 |
| Sharma, SS | 1 |
| Payne, D | 1 |
| Kubes, P | 1 |
| Lee, JJ | 1 |
| Olmos, L | 1 |
| Vanhoutte, PM | 1 |
| Schleiffer, R | 1 |
| Raul, F | 1 |
| Huang, YC | 1 |
| Fisher, PW | 1 |
| Nozik-Grayck, E | 1 |
| Piantadosi, CA | 1 |
| Yokoyama, I | 1 |
| Hayashi, S | 1 |
| Kobayashi, T | 1 |
| Negita, M | 1 |
| Namii, Y | 1 |
| Katayama, A | 1 |
| Nagasaka, T | 1 |
| Koike, C | 1 |
| Tachi, Y | 1 |
| Hayakawa, A | 1 |
| Tajiri, H | 1 |
| Takagi, H | 1 |
| Johnson, D | 2 |
| Freischlag, JA | 2 |
| Lesniak, R | 2 |
| Kelly, H | 2 |
| Mudaliar, JH | 2 |
| Cambria, RA | 2 |
| Seabrook, MD | 2 |
| Towne, JB | 2 |
| Clark, SC | 1 |
| Sudarshan, C | 1 |
| Roughan, J | 1 |
| Flecknell, PA | 1 |
| Dark, JH | 1 |
| Lepore, DA | 1 |
| Hurley, JV | 1 |
| Stewart, AG | 1 |
| Morrison, WA | 1 |
| Anderson, RL | 1 |
| Warnecke, HB | 1 |
| Schirmeier, A | 1 |
| Nüssler, AK | 1 |
| Stange, B | 1 |
| Nüssler, NC | 1 |
| Radke, C | 1 |
| Mueller, AR | 1 |
| Khiabani, KT | 1 |
| Kerrigan, CL | 1 |
27 other studies available for molsidomine and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Effects of molsidomine on retinal ischemia/reperfusion injury in rabbits.
Topics: Animals; Immunohistochemistry; Molsidomine; Rabbits; Rats; Reference Standards; Reperfusion Injury; | 2018 |
New approach to molsidomine active metabolites coming from the results of 2 models of experimental cardiology.
Topics: Animals; Anti-Asthmatic Agents; Arrhythmias, Cardiac; Creatine Kinase; Disease Models, Animal; Hemod | 2017 |
The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats.
Topics: Animals; Hedgehog Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Molsidomine; Rats; Rats | 2009 |
The effects of nitric oxide donor molsidomine on skeletal muscle damage in a rat hind limb model of ischemia-reperfusion.
Topics: Animals; Lower Extremity; Male; Molsidomine; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric | 2009 |
The nitric oxide donor molsidomine prevents ischemia/reperfusion injury of the adult rat small intestine.
Topics: Animals; Intestinal Mucosa; Intestine, Small; Lipid Peroxidation; Malondialdehyde; Molsidomine; Rats | 2003 |
Protective activity of (-)-epicatechin 3-O-gallate against peroxynitrite-mediated renal damage.
Topics: Animals; Antioxidants; Caspases; Catechin; Cell Cycle; Cell Line; Cell Survival; DNA Fragmentation; | 2003 |
[L-arginine administration improves mucosal structure in the early phase of reperfusion of small intestine transplants].
Topics: Animals; Anti-Inflammatory Agents; Arginine; Drug Therapy, Combination; Intestinal Mucosa; Intestine | 1998 |
The effects of nitric oxide on the expression of cell adhesion molecules (ICAM-1, UEA-1, and tenascin) in rats with unilateral testicular torsion.
Topics: Animals; Cell Adhesion Molecules; Gene Expression Regulation; Infertility, Male; Intercellular Adhes | 2003 |
Peroxynitrite decreases rabbit tissue factor activity in vitro.
Topics: Animals; Blood Coagulation; Brain Chemistry; Humans; In Vitro Techniques; Molsidomine; Nitric Oxide | 2004 |
Effects of molsidomine and lexipafant in hepatic ischaemia--reperfusion injury.
Topics: Animals; Imidazoles; Leucine; Liver; Male; Molsidomine; Nitric Oxide Donors; Platelet Aggregation In | 2004 |
Intrarenal administration of molsidomine, a molecule releasing nitric oxide, reduces renal ischemia-reperfusion injury in rats.
Topics: Animals; Catalase; Creatinine; Cytokines; Glutathione Peroxidase; Intercellular Adhesion Molecule-1; | 2004 |
Hemorrhagic shock resuscitation affects early and selective mesenteric artery endothelial function through a free radical-dependent mechanism.
Topics: Acetylcholine; Animals; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Fre | 2005 |
Renal protective effect of molsidomine and L-arginine in ischemia-reperfusion induced injury in rats.
Topics: Animals; Arginine; Kidney; Kidney Diseases; Male; Models, Animal; Molsidomine; Nephrectomy; Nitric O | 2005 |
Exogenous nitric oxide modulates the systemic inflammatory response and improves kidney function after risk-situation abdominal aortic surgery.
Topics: Animals; Aortic Aneurysm, Abdominal; Creatinine; Disease Models, Animal; Intercellular Adhesion Mole | 2005 |
Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Survival; Disease Models, Animal; DNA Fragmentation; | 2006 |
Nitric oxide donors reduce the rise in reperfusion-induced intestinal mucosal permeability.
Topics: Animals; Cats; Cyclic GMP; Intestinal Mucosa; Intestines; Ischemia; Molsidomine; Nitric Oxide; Nitro | 1993 |
Recovery of endothelium-dependent relaxations four weeks after ischemia and progressive reperfusion in canine coronary arteries.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arteries; Bradykinin; Coronary Vessels; Dogs; Dose-Re | 1996 |
Prophylactic administration of L-arginine improves the intestinal barrier function after mesenteric ischaemia.
Topics: Amino Acids, Essential; Analysis of Variance; Animals; Arginine; Cyclic GMP; Intestinal Mucosa; Male | 1996 |
Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury.
Topics: Animals; Arginine; Blood Pressure; Hypoxia; In Vitro Techniques; Lung; Male; Microcirculation; Molsi | 1997 |
Hepatocyte apoptosis and cytosolic calcium dynamics in ischemic injury.
Topics: Animals; Apoptosis; Cells, Cultured; DNA Fragmentation; Ischemia; Liver; Mice; Mice, Inbred BALB C; | 1997 |
Endothelial damage due to ischemia and reperfusion is prevented with SIN-1.
Topics: Animals; Endothelium, Vascular; Male; Molsidomine; Rabbits; Reperfusion Injury; Vasodilation; Vasodi | 1998 |
Endothelial damage due to ischemia and reperfusion is prevented with SIN-1.
Topics: Animals; Endothelium, Vascular; Hindlimb; Male; Molsidomine; Rabbits; Reperfusion Injury; Sodium-Pot | 1998 |
Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1.
Topics: Animals; Blood Platelets; Female; Free Radical Scavengers; Lung; Lung Transplantation; Malondialdehy | 1999 |
Prior heat stress improves survival of ischemic-reperfused skeletal muscle in vivo.
Topics: Animals; Cell Survival; Cells, Cultured; Clone Cells; Heat-Shock Response; Hot Temperature; HSP70 He | 2000 |
The effects of the nitric oxide donor molsidomine prevent in warm ischemia-reperfusion injury of the rat renal--a functional and histophatological study.
Topics: Animals; Creatinine; Ischemia; Kidney; Male; Models, Animal; Molsidomine; Nephrectomy; NG-Nitroargin | 2001 |
The combined treatment with L-arginine and methylprednisolone improves graft morphology and mucosal barrier function.
Topics: Animals; Arginine; Graft Survival; Intestinal Mucosa; Intestine, Small; Methylprednisolone; Molsidom | 2002 |
The effects of the nitric oxide donor SIN-1 on ischemia-reperfused cutaneous and myocutaneous flaps.
Topics: Animals; Cell Survival; Female; Molsidomine; Neutrophils; Nitric Oxide Donors; Reperfusion Injury; S | 2002 |