molsidomine has been researched along with Hypotension in 6 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Discrepancy was found between enhanced hypotension and attenuated relaxation of conduit arteries in response to acetylcholine (ACh) and bradykinin (BK) in nitric oxide (NO)-deficient hypertension." | 7.73 | Acetylcholine and bradykinin enhance hypotension and affect the function of remodeled conduit arteries in SHR and SHR treated with nitric oxide donors. ( Cacányiová, S; Cebová, M; Gerová, M; Kristek, F, 2005) |
| "Amitriptyline intoxication was induced by the continuous infusion of amitriptyline 0." | 5.31 | The effect of the nitric oxide synthesis inhibitor L-NAME on amitriptyline-induced hypotension in rats. ( Arkan, F; Aygoren, O; Guven, H; Kalkan, S; Kurt, S; Murat, N; Tuncok, Y, 2002) |
| "Discrepancy was found between enhanced hypotension and attenuated relaxation of conduit arteries in response to acetylcholine (ACh) and bradykinin (BK) in nitric oxide (NO)-deficient hypertension." | 3.73 | Acetylcholine and bradykinin enhance hypotension and affect the function of remodeled conduit arteries in SHR and SHR treated with nitric oxide donors. ( Cacányiová, S; Cebová, M; Gerová, M; Kristek, F, 2005) |
| "Amitriptyline intoxication was induced by the continuous infusion of amitriptyline 0." | 1.31 | The effect of the nitric oxide synthesis inhibitor L-NAME on amitriptyline-induced hypotension in rats. ( Arkan, F; Aygoren, O; Guven, H; Kalkan, S; Kurt, S; Murat, N; Tuncok, Y, 2002) |
| "We sought to investigate whether linsidomine chlorhydrate (SIN1, the active metabolite of molsidomine and a nitric oxide donor) has a toxic effect when used chronically for the treatment of impotence." | 1.29 | Intracavernous injection of linsidomine chlorhydrate in monkeys: lack of toxic effect with long-term use. ( Brock, GB; Lue, TF; Martinez-Piñeiro, L; von Heyden, B, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tuncok, Y | 1 |
| Kalkan, S | 1 |
| Murat, N | 1 |
| Arkan, F | 1 |
| Guven, H | 1 |
| Aygoren, O | 1 |
| Kurt, S | 1 |
| Takakura, K | 1 |
| Xiaohong, W | 1 |
| Takeuchi, K | 1 |
| Yasuda, Y | 1 |
| Fukuda, S | 1 |
| Gerová, M | 1 |
| Kristek, F | 1 |
| Cacányiová, S | 1 |
| Cebová, M | 1 |
| Kovách, AG | 1 |
| Lohinai, Z | 1 |
| Marczis, J | 1 |
| Balla, I | 1 |
| Dawson, TM | 1 |
| Snyder, SH | 1 |
| Teranishi, Y | 1 |
| Iriuchijima, J | 1 |
| von Heyden, B | 1 |
| Brock, GB | 1 |
| Martinez-Piñeiro, L | 1 |
| Lue, TF | 1 |
6 other studies available for molsidomine and Hypotension
| Article | Year |
|---|---|
The effect of the nitric oxide synthesis inhibitor L-NAME on amitriptyline-induced hypotension in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Drug Interactions; Enzyme | 2002 |
Deactivation of norepinephrine by peroxynitrite as a new pathogenesis in the hypotension of septic shock.
Topics: Anesthesia; Animals; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Hydrogen-Ion Concentrati | 2003 |
Acetylcholine and bradykinin enhance hypotension and affect the function of remodeled conduit arteries in SHR and SHR treated with nitric oxide donors.
Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Carotid Arteries; Hypotension; Iliac Artery; Mal | 2005 |
The effect of hemorrhagic hypotension and retransfusion and 7-nitro-indazole on rCBF, NOS catalytic activity, and cortical NO content in the cat.
Topics: Acetylcholine; Adenosine Triphosphate; Amino Acid Oxidoreductases; Analgesics; Animals; Arginine; Bl | 1994 |
Hindquarter vascular resistance as compensator for hypotension in conscious rats.
Topics: Animals; Consciousness; Ganglia; Hexamethonium; Hindlimb; Hypotension; Male; Mesenteric Artery, Supe | 1994 |
Intracavernous injection of linsidomine chlorhydrate in monkeys: lack of toxic effect with long-term use.
Topics: Animals; Blood Pressure; Hypotension; Macaca fascicularis; Macaca nemestrina; Male; Molsidomine; Pen | 1996 |