molsidomine has been researched along with Hypertension in 18 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In fawn-hooded hypertensive (FHH) rats, a model of hypertension, impaired preglomerular resistance, hyperfiltration, and progressive renal injury, we recently observed that supporting perinatal nitric oxide (NO) availability with the NO donor molsidomine persistently reduced blood pressure (BP) and ameliorated renal injury in male and female offspring." | 3.76 | Perinatal micronutrient supplements ameliorate hypertension and proteinuria in adult fawn-hooded hypertensive rats. ( Braam, B; Goldschmeding, R; Joles, JA; Koeners, MP; van der Giezen, DM, 2010) |
| "We studied the effects of long-term administration of molsidomine and pentaerythrityl tetranitrate (PETN) on the cardiovascular system of spontaneously hypertensive rats (SHR)." | 1.32 | Long-term effect of molsidomine and pentaerythrityl tetranitrate on cardiovascular system of spontaneously hypertensive rats. ( Fáberová, V; Kristek, F; Varga, I, 2003) |
| "However, it enhanced the inhibition of thrombus formation by RE 2047 from 9% to 17% (5 + 5 mg/kg) or 19% to 27% (10 + 10 mg/kg) in arterioles." | 1.30 | Interaction of Viagra with the NO donors molsidomine and RE 2047 with regard to antithrombotic and blood pressure lowering activities. ( Rehse, K; Reitner, N; Scheffler, H, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lopez-Ruiz, AF | 1 |
| Iliescu, R | 2 |
| Reckelhoff, JF | 3 |
| Koeners, MP | 2 |
| Braam, B | 2 |
| van der Giezen, DM | 2 |
| Goldschmeding, R | 2 |
| Joles, JA | 2 |
| Kristek, F | 2 |
| Fáberová, V | 1 |
| Varga, I | 1 |
| Fortepiani, LA | 2 |
| Schwenke, DO | 1 |
| Pearson, JT | 1 |
| Mori, H | 1 |
| Shirai, M | 1 |
| Sartori-Valinotti, JC | 1 |
| Yanes, LL | 1 |
| Milei, J | 1 |
| Vazquez, A | 2 |
| Lemus, J | 1 |
| Fritz, KW | 1 |
| Eglins, P | 1 |
| Höge, B | 1 |
| Hehrlein, FW | 1 |
| Lüllwitz, E | 1 |
| Kirchner, E | 1 |
| Fach, WA | 1 |
| Kostanecka, T | 1 |
| Kober, G | 1 |
| Tschudi, MR | 1 |
| Noll, G | 1 |
| Arnet, U | 1 |
| Novosel, D | 1 |
| Ganten, D | 1 |
| Lüscher, TF | 1 |
| Fouyas, IP | 1 |
| Kelly, PA | 1 |
| Ritchie, IM | 1 |
| Whittle, IR | 1 |
| Demontis, MP | 1 |
| Varoni, MV | 1 |
| Volpe, AR | 1 |
| Emanueli, C | 1 |
| Madeddu, P | 1 |
| Rehse, K | 1 |
| Scheffler, H | 1 |
| Reitner, N | 1 |
| Gerová, M | 1 |
| Degtiarev, OA | 1 |
| Ivanov, AI | 1 |
| Sotskova, TV | 1 |
| Mikerova, TM | 1 |
| Krüger, R | 1 |
| Mindlin de Aptecar, FR | 1 |
| Aptecar, M | 1 |
1 review available for molsidomine and Hypertension
| Article | Year |
|---|---|
Sex differences in oxidative stress and the impact on blood pressure control and cardiovascular disease.
Topics: Acetophenones; Animals; Antioxidants; Ascorbic Acid; Blood Pressure; Cardiovascular Diseases; Catala | 2007 |
3 trials available for molsidomine and Hypertension
| Article | Year |
|---|---|
Double-blind controlled trial of molsidomine in hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertensi | 1980 |
[Long-term antihypertensive effect of delayed-action molsidomine].
Topics: Blood Pressure; Blood Pressure Monitors; Coronary Disease; Delayed-Action Preparations; Dose-Respons | 1994 |
Molsidomine--an effective antianginal drug. Results of an acute randomized stress-testing study.
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Humans; | 1985 |
14 other studies available for molsidomine and Hypertension
| Article | Year |
|---|---|
Refractory blood pressure in female SHR to increased oxidative stress is not mediated by NO or by upregulation of renal antioxidant enzymes.
Topics: Animals; Antioxidants; Blood Pressure; Female; Hypertension; Isoprostanes; Kidney; Male; Molsidomine | 2010 |
Perinatal micronutrient supplements ameliorate hypertension and proteinuria in adult fawn-hooded hypertensive rats.
Topics: Animals; Arginine; Ascorbic Acid; Blood Pressure; Dietary Supplements; Female; Hypertension; Kidney | 2010 |
Long-term effect of molsidomine and pentaerythrityl tetranitrate on cardiovascular system of spontaneously hypertensive rats.
Topics: Animals; Aorta; Aorta, Thoracic; Blood Platelets; Blood Pressure; Body Weight; Cardiovascular System | 2003 |
Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls.
Topics: Animals; Blood Pressure; Hemodynamics; Hypertension; Kidney; Male; Molsidomine; Nitrates; Nitric Oxi | 2005 |
Does central nitric oxide elicit pulmonary hypertension in conscious rats?
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Blood Pressure; Enzyme Inhibitors; Heart Ra | 2006 |
A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats.
Topics: Animals; Animals, Newborn; Blood Pressure; Disease Models, Animal; Female; Glomerular Filtration Rat | 2008 |
[Comparative hemodynamic studies with molsidomine and isosorbide dinitrate after aortocoronary bypass].
Topics: Coronary Artery Bypass; Hemodynamics; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; | 1982 |
Alterations in coronary artery vascular reactivity of hypertensive Ren-2 transgenic rats.
Topics: Acetylcholine; Animals; Animals, Genetically Modified; Arginine; Coronary Vessels; Endothelium, Vasc | 1994 |
Cerebrovascular effects of nitric oxide manipulation in spontaneously hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoradiography; Blood Pressure; Cereb | 1997 |
Role of nitric oxide synthase inhibition in the acute hypertensive response to intracerebroventricular cadmium.
Topics: Animals; Arginine; Blood Pressure; Brain Chemistry; Cadmium; Calcium Chloride; Citrulline; Enzyme In | 1998 |
Interaction of Viagra with the NO donors molsidomine and RE 2047 with regard to antithrombotic and blood pressure lowering activities.
Topics: Animals; Arterioles; Blood Pressure; Drug Interactions; Fibrinolytic Agents; Hypertension; Molsidomi | 1999 |
Efficiency of NO donors in substituting impaired endogenous NO production: a functional and morphological study.
Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Enzyme Activation; Enzyme Inhibitors; Hypertensi | 2001 |
[Nifedipine and molsidomine treatment of circulatory insufficiency in elderly patients with hypertension].
Topics: Age Factors; Aged; Aged, 80 and over; Cardiac Glycosides; Diuretics; Drug Evaluation; Drug Therapy, | 1990 |
[Problems in acute therapy of coronary heart disease using drugs that reduce preload and afterload].
Topics: Coronary Disease; Heart Failure; Hemodynamics; Humans; Hypertension; Molsidomine; Nifedipine; Nitrog | 1987 |