Page last updated: 2024-10-31

molsidomine and Endotoxemia

molsidomine has been researched along with Endotoxemia in 4 studies

Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.

Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.

Research Excerpts

ExcerptRelevanceReference
"Cholestasis and endotoxemia have been demonstrated to cause hepatocyte apoptosis through caspase-mediated pathways."5.32The nitric oxide donor molsidomine improves survival and reduces hepatocyte apoptosis in cholestasis and endotoxemia. ( Brems, JJ; Brown, KM; Ding, JW; Gamelli, RL; Hartman, GG; Moazzam, FN, 2003)
"Cholestasis and endotoxemia have been demonstrated to cause hepatocyte apoptosis through caspase-mediated pathways."1.32The nitric oxide donor molsidomine improves survival and reduces hepatocyte apoptosis in cholestasis and endotoxemia. ( Brems, JJ; Brown, KM; Ding, JW; Gamelli, RL; Hartman, GG; Moazzam, FN, 2003)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Stahl, W1
Matejovic, M1
Radermacher, P1
Brown, KM1
Brems, JJ1
Moazzam, FN1
Hartman, GG1
Gamelli, RL1
Ding, JW1
Walther, A1
Barth, C1
Gebhard, MM1
Martin, E1
Siegemund, M1
Van Bommel, J1
Sinaasappel, M1
Schwarte, LA1
Studer, W1
Girard, T1
Vollebregt, K1
Ince, C1

Other Studies

4 other studies available for molsidomine and Endotoxemia

ArticleYear
Inhibition of nitric oxide synthase during sepsis: revival because of isoform selectivity?
    Shock (Augusta, Ga.), 2010, Volume: 34, Issue:3

    Topics: Acidosis; Animals; Blood Circulation; Clinical Trials, Phase II as Topic; Early Termination of Clini

2010
The nitric oxide donor molsidomine improves survival and reduces hepatocyte apoptosis in cholestasis and endotoxemia.
    Journal of the American College of Surgeons, 2003, Volume: 197, Issue:2

    Topics: Animals; Apoptosis; Caspase 3; Caspases; Cholestasis; Common Bile Duct; Endotoxemia; Hepatocytes; Li

2003
Role of nitric oxide in leukocyte-independent endothelial damage during experimental endotoxemia.
    Shock (Augusta, Ga.), 2003, Volume: 20, Issue:3

    Topics: Animals; Cell Adhesion; Endothelium, Vascular; Endotoxemia; Erythrocytes; Leukocytes; Male; Molsidom

2003
The NO donor SIN-1 improves intestinal-arterial P(CO(2)) gap in experimental endotoxemia: an animal study.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:6

    Topics: Animals; Arteries; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Endotoxemia; Intestines;

2007
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