molsidomine and Endotoxemia
molsidomine has been researched along with Endotoxemia in 4 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Cholestasis and endotoxemia have been demonstrated to cause hepatocyte apoptosis through caspase-mediated pathways." | 5.32 | The nitric oxide donor molsidomine improves survival and reduces hepatocyte apoptosis in cholestasis and endotoxemia. ( Brems, JJ; Brown, KM; Ding, JW; Gamelli, RL; Hartman, GG; Moazzam, FN, 2003) |
"Cholestasis and endotoxemia have been demonstrated to cause hepatocyte apoptosis through caspase-mediated pathways." | 1.32 | The nitric oxide donor molsidomine improves survival and reduces hepatocyte apoptosis in cholestasis and endotoxemia. ( Brems, JJ; Brown, KM; Ding, JW; Gamelli, RL; Hartman, GG; Moazzam, FN, 2003) |
Research
Studies (4)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (75.00) | 29.6817 |
2010's | 1 (25.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Stahl, W | 1 |
Matejovic, M | 1 |
Radermacher, P | 1 |
Brown, KM | 1 |
Brems, JJ | 1 |
Moazzam, FN | 1 |
Hartman, GG | 1 |
Gamelli, RL | 1 |
Ding, JW | 1 |
Walther, A | 1 |
Barth, C | 1 |
Gebhard, MM | 1 |
Martin, E | 1 |
Siegemund, M | 1 |
Van Bommel, J | 1 |
Sinaasappel, M | 1 |
Schwarte, LA | 1 |
Studer, W | 1 |
Girard, T | 1 |
Vollebregt, K | 1 |
Ince, C | 1 |
Other Studies
4 other studies available for molsidomine and Endotoxemia
Article | Year |
---|---|
Inhibition of nitric oxide synthase during sepsis: revival because of isoform selectivity?
Topics: Acidosis; Animals; Blood Circulation; Clinical Trials, Phase II as Topic; Early Termination of Clini | 2010 |
The nitric oxide donor molsidomine improves survival and reduces hepatocyte apoptosis in cholestasis and endotoxemia.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cholestasis; Common Bile Duct; Endotoxemia; Hepatocytes; Li | 2003 |
Role of nitric oxide in leukocyte-independent endothelial damage during experimental endotoxemia.
Topics: Animals; Cell Adhesion; Endothelium, Vascular; Endotoxemia; Erythrocytes; Leukocytes; Male; Molsidom | 2003 |
The NO donor SIN-1 improves intestinal-arterial P(CO(2)) gap in experimental endotoxemia: an animal study.
Topics: Animals; Arteries; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Endotoxemia; Intestines; | 2007 |