molsidomine has been researched along with Coronary Heart Disease in 105 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Excerpt | Relevance | Reference |
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"Pharmacokinetic measurements were performed in two groups of patients with coronary heart disease (CHD) after single and multiple dosing of 2 mg linsidomine (SIN 1)." | 9.07 | Pharmacokinetics of linsidomine (SIN 1) after single and multiple intravenous short infusions in patients with renal insufficiency. ( Degré, S; Gaertner, W; Ostrowski, J; Sennesael, J; Stolear, JC; Unger, P; Verbeelen, D; von Hattingberg, HM, 1993) |
"In a randomised, crossover trial, 20 patients with electrocardiographically proven coronary heart disease and exercise-inducible angina pectoris, the antiischemic effect of gallopamil (3 x 50 mg) and molsidomine (2 x 2 mg) were studied." | 9.06 | [Gallopamil and molsidomine in patients with coronary heart disease. A comparative study]. ( Zebe, H, 1989) |
"Combination treatment with isosorbide dinitrate with molsidomine in a slow-release form (in the nitrate free interval) showed a distinct improvement in patients with angina pectoris refractory to treatment with reduction of complaints." | 7.69 | [Influence of combination therapy (isosorbide dinitrate and molsidomine) on the incidence of angina pectoris in patients with coronary heart disease]. ( Ciopor, M; Fischer, A; Hess, OM; Turina, J, 1997) |
" In 13 out of 16 patients (5 women, 11 men, 62 [53/71] years [median, 25%/75%-percentiles]) with chronic heart failure (NYHA stage II-III; median angiographic ejection fraction (EF) 55%) and coronary artery disease (stenosis of at least 75%) the development of tolerance under the continuous infusion of high doses of nitroglycerin (10 mg/h) was observed." | 7.68 | [Hemodynamic effect of molsidomine in coronary patients with heart failure with clinically manifest nitrate tolerance]. ( Bodemann, T; Danne, O; Eichstädt, H; Hochrein, H; Möckel, M; Müller, R; Piske, G; Störk, S; Störk, T, 1993) |
"The haemodynamic effects of a single dose of intravenous molsidomine were assessed in 12 patients with severe coronary disease." | 7.67 | Haemodynamic effects of molsidomine in patients with severe chronic coronary disease. ( Augé, JM; Bosch, X; Crexells, C; Garcia, J; Lidón, RM; Oriol, A; Pina, C, 1985) |
"To test the clinically supposed development of tolerance during chronic molsidomine therapy we studied a total of 11 patients with angiographically-proven coronary heart disease at rest and during ergometric exercise (supine position; submaximal, i." | 7.67 | Acute and chronic effects of molsidomine on pulmonary artery pressure and work capacity in patients with coronary heart disease. ( Eggeling, T; Hilger, HH; Jansen, W; Meyer, L; Tauchert, M, 1987) |
"We performed a double-blind crossover study with molsidomine in 10 patients with coronary heart disease." | 7.66 | Effects of molsidomine on exercise tolerance in patients with coronary heart disease. ( Demaret, B; Denolin, H; Messin, R, 1983) |
"To analyze the mechanisms of action of molsidomine, a new antianginal drug, 10 patients with coronary artery disease and exertional angina pectoris were studied." | 7.66 | Hemodynamic effects of molsidomine at rest and during submaximal and maximal exercise in patients with coronary artery disease limited by exertional angina pectoris. ( Brasseur, LA; Cosyns, J; Detry, JM; Melin, J; Rousseau, MF, 1981) |
"The effect of molsidomine on hemodynamics and myocardial ischemia were studied in 48 patients with acute myocardial infarction." | 7.66 | [Effect of molsidomine on hemodynamics and myocardial ischemia in patients with acute myocardial infarction (author's transl)]. ( Bussmann, WD; Kaltenbach, M; Neidl, K, 1982) |
"Pharmacokinetic measurements were performed in two groups of patients with coronary heart disease (CHD) after single and multiple dosing of 2 mg linsidomine (SIN 1)." | 5.07 | Pharmacokinetics of linsidomine (SIN 1) after single and multiple intravenous short infusions in patients with renal insufficiency. ( Degré, S; Gaertner, W; Ostrowski, J; Sennesael, J; Stolear, JC; Unger, P; Verbeelen, D; von Hattingberg, HM, 1993) |
"In a randomised, crossover trial, 20 patients with electrocardiographically proven coronary heart disease and exercise-inducible angina pectoris, the antiischemic effect of gallopamil (3 x 50 mg) and molsidomine (2 x 2 mg) were studied." | 5.06 | [Gallopamil and molsidomine in patients with coronary heart disease. A comparative study]. ( Zebe, H, 1989) |
"Studies of the efficacy of molsidomine, previously performed on our service, demonstrated that a clear antianginal effect in the longterm treatment of angina pectoris could only be achieved with a regimen of the standard 2 mg dose when given six times daily." | 5.05 | [Anti-ischemic effect of 8 mg molsidomin in retard form]. ( Blasini, R; Brügmann, U; Rudolph, W, 1984) |
"Using a randomized, double-blind, crossover protocol, we compared the effects of oral molsidomine (Corvaton, 6 mg/day) and placebo, administered alternately for two 14-day periods, on the exercise tolerance of 25 outpatients with coronary heart disease." | 5.05 | Exercise tolerance in coronary patients: randomized trial of two-week treatment with molsidomine versus placebo. ( Messin, R, 1985) |
"In the first study the hemodynamic effects of standard doses of molsidomine (2 mg intravenously), isosorbide dinitrate (ISDN) (5 mg sublingually), and nifedipine (20 mg sublingually) were assessed at rest and under exercise conditions in a group of 30 patients with coronary heart disease." | 5.05 | Hemodynamic effects of molsidomine, isosorbide dinitrate, and nifedipine at rest and during exercise. ( Dougherty, C; Rutsch, W; Schartl, M; Schmutzler, H, 1985) |
"Organic nitrates still are one of the most important drug classes used in the treatment of an acute coronary syndrome and stable coronary artery disease as well as acute and chronic congestive heart failure." | 4.84 | [Recent findings on nitrates: their action, bioactivation and development of tolerance]. ( Münzel, T, 2008) |
"Molsidomine is an established drug for the treatment of coronary heart disease." | 4.78 | Molsidomine. ( Reden, J, 1990) |
"The cardioprotective and antithrombotic activity of molsidomine, a novel therapeutic agent for the treatment of coronary heart disease, was investigated in a series of animal models of myocardial ischemia." | 4.77 | The activity of molsidomine in experimental models of ischemic cardiac disease. ( Martorana, PA; Nitz, RE, 1985) |
"Combination treatment with isosorbide dinitrate with molsidomine in a slow-release form (in the nitrate free interval) showed a distinct improvement in patients with angina pectoris refractory to treatment with reduction of complaints." | 3.69 | [Influence of combination therapy (isosorbide dinitrate and molsidomine) on the incidence of angina pectoris in patients with coronary heart disease]. ( Ciopor, M; Fischer, A; Hess, OM; Turina, J, 1997) |
" In 13 out of 16 patients (5 women, 11 men, 62 [53/71] years [median, 25%/75%-percentiles]) with chronic heart failure (NYHA stage II-III; median angiographic ejection fraction (EF) 55%) and coronary artery disease (stenosis of at least 75%) the development of tolerance under the continuous infusion of high doses of nitroglycerin (10 mg/h) was observed." | 3.68 | [Hemodynamic effect of molsidomine in coronary patients with heart failure with clinically manifest nitrate tolerance]. ( Bodemann, T; Danne, O; Eichstädt, H; Hochrein, H; Möckel, M; Müller, R; Piske, G; Störk, S; Störk, T, 1993) |
"To test the clinically supposed development of tolerance during chronic molsidomine therapy we studied a total of 11 patients with angiographically-proven coronary heart disease at rest and during ergometric exercise (supine position; submaximal, i." | 3.67 | Acute and chronic effects of molsidomine on pulmonary artery pressure and work capacity in patients with coronary heart disease. ( Eggeling, T; Hilger, HH; Jansen, W; Meyer, L; Tauchert, M, 1987) |
"The pharmacokinetics of molsidomine were investigated in the plasma and urine of healthy male volunteers and patients with coronary heart disease after intravenous and/or oral administration of different galenic dosage forms of molsidomine." | 3.67 | Pharmacokinetics of molsidomine in humans. ( Ostrowski, J; Resag, K, 1985) |
"The haemodynamic effects of a single dose of intravenous molsidomine were assessed in 12 patients with severe coronary disease." | 3.67 | Haemodynamic effects of molsidomine in patients with severe chronic coronary disease. ( Augé, JM; Bosch, X; Crexells, C; Garcia, J; Lidón, RM; Oriol, A; Pina, C, 1985) |
"The effect of molsidomine on hemodynamics and myocardial ischemia were studied in 48 patients with acute myocardial infarction." | 3.66 | [Effect of molsidomine on hemodynamics and myocardial ischemia in patients with acute myocardial infarction (author's transl)]. ( Bussmann, WD; Kaltenbach, M; Neidl, K, 1982) |
"To analyze the mechanisms of action of molsidomine, a new antianginal drug, 10 patients with coronary artery disease and exertional angina pectoris were studied." | 3.66 | Hemodynamic effects of molsidomine at rest and during submaximal and maximal exercise in patients with coronary artery disease limited by exertional angina pectoris. ( Brasseur, LA; Cosyns, J; Detry, JM; Melin, J; Rousseau, MF, 1981) |
") on platelet function, on the plasma concentrations of 6-oxo-PGF1 alpha, the stable metabolite of prostaglandin I2, and thromboxane B2, the stable metabolite of thromboxine A2 was determined in ten patients with coronary heart disease." | 3.66 | [Molsidomine, a coronary drug with platelet-aggregating inhibitory activity]. ( Punzengruber, C; Silberbauer, K; Sinzinger, H; Slany, J, 1982) |
"We performed a double-blind crossover study with molsidomine in 10 patients with coronary heart disease." | 3.66 | Effects of molsidomine on exercise tolerance in patients with coronary heart disease. ( Demaret, B; Denolin, H; Messin, R, 1983) |
" Up to 8 h after dosing in the morning, more marked and sustained effects were observed with the nitrate (ST at 2 h, -82%; p < 0." | 2.69 | Clinical comparison of antiischemic efficacy of isosorbide dinitrate and molsidomine. ( Beyerle, A; Lehmann, G; Reiniger, G; Schömig, A, 1998) |
"Thus molsidomine has an early positive effect on FMD in addition to a delayed vasodilator effect." | 2.69 | Molsidomine improves flow-dependent vasodilation in brachial arteries of patients with coronary artery disease. ( Adnot, S; Belhassen, L; Benacerraf, S; Carville, C; Dubois-Randé, JL; Pelle, G; Sediame, S, 2000) |
"Treatment with linsidomine and molsidomine was associated with a modest improvement in the long-term angiographic result after angioplasty but had no effect on clinical outcome." | 2.68 | Effect of the direct nitric oxide donors linsidomine and molsidomine on angiographic restenosis after coronary balloon angioplasty. The ACCORD Study. Angioplastic Coronaire Corvasal Diltiazem. ( Bassand, JP; Battaglia, S; Béard, T; Bertrand, B; Bertrand, ME; Boschat, J; Coste, P; Crochet, PD; Desveaux, B; Drobinski, G; Dubois-Randé, JL; Finet, G; Giraud, T; Grollier, G; Juillière, Y; Juliard, JM; Lablanche, JM; Le Breton, H; Leclercq, F; Letac, B; Livarek, B; Lusson, JR; Metzger, JP; Quiret, JC; Virot, P, 1997) |
"Molsidomine was associated with a significant reduction of the left ventricular end-diastolic pressure and an increase in Vcf." | 2.66 | Preload or afterload reduction: which is more beneficial for patients with ischemic heart disease? ( Caralis, DG; Kyriakides, Z, 1988) |
"In 28 patients with unstable angina pectoris biplane coronary angiography was performed in the acute stage." | 2.65 | [Dynamics of critical stenosis in patients with unstable angina pectoris]. ( Karsch, KR; Niemczyk, P; Seipel, L; Voelker, W, 1984) |
" In general, due to a large therapeutic dose range, dosage adjustments are not required on the basis of clinical experience." | 1.29 | Clinical pharmacokinetics of molsidomine. ( Parnham, MJ; Rosenkranz, B; Winkelmann, BR, 1996) |
"Combinations of antianginal drugs may be used for an additive effect against angina, but also to off-set unwanted effects of one drug with another, either by direct effects or by a reduction of dosage of each drug." | 1.27 | Interactions of vasodilators with calcium entry- and beta-blockers in patients with coronary heart disease. ( Adam, WE; Haerer, W; Henze, E; Hermann, T; Kohler, J; Kress, P; Stauch, M, 1986) |
"Molsidomine protected the treated animals from early (10 min) post-ischaemic ventricular fibrillation (0 of 20 vs 6 of 20, P = 0." | 1.27 | Molsidomine prevents post-ischaemic ventricular fibrillation in dogs. ( Cano, JP; Guillen, JC; Jouve, R; Langlet, F; Puddu, PE; Rolland, PH; Serradimigni, A, 1986) |
"Molsidomine was administered intraduodenally to anesthetized dogs which were instrumented for measurements of aortic and left ventricular (LV) pressures, coronary perfusion pressure, intramyocardial pressure in the subendocardium, and subendocardial and subepicardial myocardial blood flow in the ischemic and non-ischemic regions." | 1.27 | The effect of molsidomine on intramyocardial pressure and regional myocardial blood flow in the canine ischemic myocardium. ( Bito, K; Fukuhara, T; Kawakita, S; Kinoshita, M; Mashiro, I; Mitsunami, K; Motomura, M, 1985) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 69 (65.71) | 18.7374 |
1990's | 32 (30.48) | 18.2507 |
2000's | 4 (3.81) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Münzel, T | 2 |
Genest, M | 1 |
Pochmalicki, G | 1 |
Zygelman, M | 2 |
Neukirch, F | 2 |
Mérillon, JP | 2 |
Dahan, M | 2 |
Trouillet, JL | 1 |
Juliard, JM | 3 |
Pansard, Y | 2 |
Gourgon, R | 2 |
Di Giacomo, G | 1 |
Nicolella, U | 1 |
Puligheddu, M | 1 |
Tripodi, A | 1 |
D'Ascoli, C | 1 |
Di Virgilio, D | 1 |
Berdeaux, A | 1 |
Giudicelli, JF | 1 |
Blasini, R | 1 |
Brügmann, U | 1 |
Rudolph, W | 5 |
Fach, WA | 2 |
Becker, HJ | 1 |
Thulesius, O | 1 |
Strasser, R | 2 |
Klepzig, H | 3 |
Ostrowski, J | 4 |
Resag, K | 3 |
Osterspey, A | 4 |
Jansen, W | 5 |
Tauchert, M | 5 |
Schell, U | 2 |
Fuchs, M | 2 |
Hombach, V | 2 |
Hilger, HH | 4 |
Poincelot, B | 1 |
Russo-Marie, F | 1 |
Romano, M | 1 |
de Caprio, L | 1 |
Meccariello, P | 1 |
Cuomo, S | 1 |
Baldini, F | 1 |
D'Ascia, C | 1 |
Steinberg, G | 1 |
Chiariello, M | 1 |
Karsch, KR | 1 |
Niemczyk, P | 1 |
Voelker, W | 1 |
Seipel, L | 1 |
Kuz'ko, NV | 1 |
Schulz, W | 1 |
Wendt, T | 1 |
Scherer, D | 1 |
Kober, G | 3 |
Nitz, RE | 2 |
Mogilev, AM | 1 |
Göbel, H | 1 |
Messin, R | 2 |
Demaret, B | 1 |
Denolin, H | 1 |
Halawa, B | 1 |
Michel, PL | 1 |
Squara, P | 1 |
Laurent, S | 1 |
Silberbauer, K | 1 |
Slany, J | 1 |
Sinzinger, H | 1 |
Punzengruber, C | 1 |
Kaliman, J | 1 |
Uhlir, H | 1 |
Klicpera, M | 1 |
Gasilin, VS | 1 |
Kramer, AA | 1 |
Samoilenko, LE | 1 |
Gross, GJ | 1 |
Gharaibeh, M | 1 |
Meyer, J | 4 |
Sprauer, R | 1 |
Krebs, W | 1 |
Erbel, R | 3 |
Schweizer, P | 1 |
Effert, S | 1 |
Detry, JM | 1 |
Melin, J | 1 |
Brasseur, LA | 1 |
Cosyns, J | 1 |
Rousseau, MF | 1 |
Litvitskiĭ, PF | 1 |
Ol'binskaia, LI | 1 |
Sandrikov, VA | 1 |
Aksiuk, MA | 1 |
Fiedler, VB | 2 |
Bussmann, WD | 1 |
Neidl, K | 1 |
Kaltenbach, M | 1 |
Dubois-Rande, JL | 3 |
Dupouy, P | 1 |
Geschwind, H | 1 |
Castaigne, A | 1 |
Adnot, S | 2 |
Kostanecka, T | 1 |
Kenny, D | 1 |
Coughlan, MG | 1 |
Kampine, JP | 1 |
Montgomery, RR | 1 |
Bosnjak, ZJ | 1 |
Warltier, DC | 1 |
Hug, J | 1 |
Hasenfuss, G | 1 |
Wollschläger, H | 1 |
Just, HJ | 1 |
Bonzel, T | 1 |
Kurz, S | 1 |
Heitzer, T | 1 |
Luhmann, C | 1 |
Just, H | 1 |
Weimer, M | 1 |
Pizzulli, L | 1 |
Reichert, H | 1 |
Lüderitz, B | 1 |
Ferguson, JJ | 1 |
Bender, M | 1 |
Vallbracht, C | 1 |
Sievert, H | 1 |
Ohlmeier, H | 1 |
Gleichmann, U | 1 |
Sennesael, J | 1 |
Verbeelen, D | 1 |
Degré, S | 2 |
Unger, P | 2 |
Stolear, JC | 1 |
von Hattingberg, HM | 1 |
Gaertner, W | 1 |
Störk, T | 1 |
Möckel, M | 1 |
Störk, S | 1 |
Piske, G | 1 |
Danne, O | 1 |
Bodemann, T | 1 |
Müller, R | 1 |
Eichstädt, H | 1 |
Hochrein, H | 1 |
Jost, S | 4 |
Sturm, M | 1 |
Hausmann, D | 1 |
Lippolt, P | 1 |
Lichtlen, PR | 2 |
Rosenkranz, B | 1 |
Winkelmann, BR | 1 |
Parnham, MJ | 1 |
Dukát, A | 1 |
Lablanche, JM | 1 |
Grollier, G | 1 |
Lusson, JR | 1 |
Bassand, JP | 1 |
Drobinski, G | 1 |
Bertrand, B | 1 |
Battaglia, S | 1 |
Desveaux, B | 1 |
Juillière, Y | 1 |
Metzger, JP | 1 |
Coste, P | 1 |
Quiret, JC | 1 |
Crochet, PD | 1 |
Letac, B | 1 |
Boschat, J | 1 |
Virot, P | 1 |
Finet, G | 1 |
Le Breton, H | 1 |
Livarek, B | 1 |
Leclercq, F | 1 |
Béard, T | 1 |
Giraud, T | 1 |
Bertrand, ME | 1 |
Lehmann, G | 1 |
Reiniger, G | 1 |
Beyerle, A | 3 |
Schömig, A | 1 |
Ciopor, M | 1 |
Fischer, A | 1 |
Turina, J | 1 |
Hess, OM | 1 |
Feld, S | 1 |
Smalling, RW | 1 |
Belhassen, L | 1 |
Carville, C | 1 |
Pelle, G | 1 |
Sediame, S | 1 |
Benacerraf, S | 1 |
Gryglewski, RJ | 1 |
Swies, J | 1 |
Leone, A | 1 |
Staroukine, M | 1 |
Berkenboom, G | 1 |
Darius, H | 3 |
Beisiegel, B | 1 |
Rupprecht, HJ | 2 |
Hafner, G | 1 |
Pop, T | 2 |
Treese, N | 1 |
Frey, AW | 1 |
Haider, M | 1 |
Rösch, A | 1 |
Rösch, R | 1 |
Drummer, C | 1 |
Gerzer, R | 2 |
Theisen, K | 2 |
Dirschinger, J | 2 |
Caralis, DG | 2 |
Kyriakides, Z | 2 |
Ioakimides, C | 1 |
Vrolix, M | 1 |
Piessens, J | 1 |
De Geest, H | 1 |
Rafflenbeul, W | 2 |
Reil, GH | 1 |
Gulba, D | 2 |
Knop, I | 2 |
Hecker, H | 2 |
Böhme, E | 1 |
Reden, J | 1 |
Reil, G | 1 |
Auricchio, A | 1 |
Frombach, R | 1 |
Lichtlen, P | 1 |
Haufe, MC | 1 |
Weil, J | 1 |
Heim, JM | 1 |
Ernst, JE | 1 |
Kyriakidis, M | 1 |
Vyssoulis, G | 1 |
Sfikakis, P | 1 |
Kyriakidis, C | 1 |
Pitsavos, C | 1 |
Valsamis, K | 1 |
Nomikos, V | 1 |
Toutouzas, P | 1 |
Brovko, EA | 1 |
Denisiuk, VI | 1 |
Kolesnik, PF | 1 |
Zebe, H | 1 |
Nemirovskaia, MA | 1 |
Zharov, EI | 1 |
Vertkin, AL | 1 |
Alekperov, EZ | 1 |
Kipshidze, NN | 1 |
Chumburidze, VB | 1 |
Tomov, I | 1 |
Alpert, JS | 1 |
Mosca, SM | 1 |
Gelpi, RJ | 1 |
Cingolani, HE | 1 |
Erbel, E | 1 |
Schmucker, B | 1 |
Reusch, U | 1 |
Stauch, M | 2 |
Haerer, W | 2 |
Henze, E | 1 |
Hermann, T | 1 |
Kohler, J | 1 |
Kress, P | 1 |
Adam, WE | 2 |
Meyer, L | 2 |
Eggeling, T | 2 |
Krüger, R | 1 |
Gilfrich, HJ | 1 |
Sterkowicz, S | 1 |
Weill, D | 1 |
Maclouf, J | 1 |
Vallantin, X | 1 |
Wautier, JL | 1 |
Serruys, PW | 1 |
Deckers, JW | 1 |
Luijten, HE | 1 |
Reiber, JH | 1 |
Tijssen, JG | 1 |
Chadha, D | 1 |
Hugenholtz, PG | 1 |
Trifunović, S | 1 |
Pavlović, K | 1 |
Cano, JP | 1 |
Guillen, JC | 1 |
Jouve, R | 1 |
Langlet, F | 1 |
Puddu, PE | 1 |
Rolland, PH | 1 |
Serradimigni, A | 1 |
Vakaliuk, IP | 1 |
Schartl, M | 1 |
Dougherty, C | 1 |
Rutsch, W | 1 |
Schmutzler, H | 1 |
Rogg-Dussler, G | 1 |
Sigel, H | 1 |
Kinoshita, M | 1 |
Mashiro, I | 1 |
Mitsunami, K | 1 |
Fukuhara, T | 1 |
Motomura, M | 1 |
Bito, K | 1 |
Kawakita, S | 1 |
Crexells, C | 1 |
Lidón, RM | 1 |
Augé, JM | 1 |
Bosch, X | 1 |
Pina, C | 1 |
Garcia, J | 1 |
Oriol, A | 1 |
Tsujibayashi, T | 1 |
Niwa, A | 1 |
Taniguchi, K | 1 |
Takeuchi, J | 1 |
Gaul, G | 1 |
Voegele, D | 1 |
Brockmeier, D | 1 |
Goch, JH | 1 |
Rosiek, S | 1 |
Brzozowski, R | 1 |
Bała, T | 1 |
Tkaczewski, W | 1 |
Adamska-Dyniewska, H | 1 |
König, FK | 1 |
Grewe, R | 1 |
Wörz, K | 1 |
Martorana, PA | 1 |
Furkalo, NK | 1 |
Ivashchenko, TI | 1 |
Romanenko, AI | 1 |
9 reviews available for molsidomine and Coronary Heart Disease
Article | Year |
---|---|
[Recent findings on nitrates: their action, bioactivation and development of tolerance].
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Coronary Disease; Drug Tolerance; End | 2008 |
[Acute coronary syndromes with ST-segment elevation].
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Angioplasty, Balloon, Coronary; Angiotensin-Converti | 2004 |
Cardiovascular pharmacology of molsidomine.
Topics: Animals; Biological Availability; Coronary Disease; Heart; Liver; Molsidomine; Oxadiazoles; Sydnones | 1984 |
Clinical comparison of nitrates and sydnonimines.
Topics: Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; He | 1991 |
[Pharmacology of molsidomine and its active metabolites].
Topics: Animals; Coronary Circulation; Coronary Disease; Cyclic AMP; Humans; Molsidomine; Muscle, Smooth, Va | 1990 |
[Treatment of myocardial ischemia with molsidomine].
Topics: Angina Pectoris; Coronary Disease; Electrocardiography; Humans; Molsidomine | 1990 |
Molsidomine.
Topics: Animals; Coronary Circulation; Coronary Disease; Drug Tolerance; Humans; Molsidomine; Nitric Oxide; | 1990 |
[Molsidomine in the treatment of ischemic heart disease].
Topics: Coronary Disease; Humans; Molsidomine | 1987 |
The activity of molsidomine in experimental models of ischemic cardiac disease.
Topics: Animals; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Electric Stimulation; | 1985 |
30 trials available for molsidomine and Coronary Heart Disease
Article | Year |
---|---|
[Anti-ischemic effect of 8 mg molsidomin in retard form].
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; D | 1984 |
[Effect duration and dose-response relation of molsidomine in patients with coronary heart disease].
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; D | 1984 |
[Hemodynamic effect of molsidomine in acute administration and as a long-term medication].
Topics: Antihypertensive Agents; Coronary Disease; Hemodynamics; Humans; Long-Term Care; Male; Middle Aged; | 1983 |
Effects of long-term molsidomine treatment versus isosorbide dinitrate and placebo on exercise tolerance in stable angina.
Topics: Angina Pectoris; Coronary Disease; Electrocardiography; Exercise Test; Female; Hemodynamics; Humans; | 1984 |
[Dynamics of critical stenosis in patients with unstable angina pectoris].
Topics: Angina Pectoris; Angina, Unstable; Coronary Angiography; Coronary Circulation; Coronary Disease; Hem | 1984 |
[Diameter changes of epicardial coronary arteries and coronary stenoses after intracoronary application of SIN 1, a molsidomine metabolite].
Topics: Coronary Disease; Coronary Vessels; Double-Blind Method; Humans; Injections, Intra-Arterial; Molsido | 1983 |
Long-term treatment of patients with coronary heart disease using isosorbide dinitrate, nifedipine and molsidomine.
Topics: Adult; Blood Pressure; Coronary Disease; Drug Administration Schedule; Drug Tolerance; Hemodynamics; | 1983 |
[Circadian variation of ischaemic ST lowering in exercise ECG (author's transl)].
Topics: Adult; Blood Pressure; Circadian Rhythm; Coronary Disease; Double-Blind Method; Electrocardiography; | 1981 |
[Long-term antihypertensive effect of delayed-action molsidomine].
Topics: Blood Pressure; Blood Pressure Monitors; Coronary Disease; Delayed-Action Preparations; Dose-Respons | 1994 |
[Coronary dilatation after intracoronary administration of SIN-1 and intravenous molsidomine administration].
Topics: Adult; Aged; Angina Pectoris; Coronary Circulation; Coronary Disease; Coronary Vessels; Double-Blind | 1994 |
Meeting highlights: nitric oxide donors.
Topics: Angioplasty, Balloon, Coronary; Coronary Disease; Diltiazem; Humans; Isosorbide Dinitrate; Molsidomi | 1994 |
SIN-1 has no direct myocardial anti-ischemic action.
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease; Double-Blind Method; Electro | 1993 |
Pharmacokinetics of linsidomine (SIN 1) after single and multiple intravenous short infusions in patients with renal insufficiency.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Coronary Disease; Drug Admi | 1993 |
Effect of the direct nitric oxide donors linsidomine and molsidomine on angiographic restenosis after coronary balloon angioplasty. The ACCORD Study. Angioplastic Coronaire Corvasal Diltiazem.
Topics: Aged; Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Disease; Coronary Vessels; Dilt | 1997 |
Clinical comparison of antiischemic efficacy of isosorbide dinitrate and molsidomine.
Topics: Blood Pressure; Coronary Disease; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Meth | 1998 |
Molsidomine improves flow-dependent vasodilation in brachial arteries of patients with coronary artery disease.
Topics: Blood Flow Velocity; Brachial Artery; Coronary Disease; Double-Blind Method; Endothelium, Vascular; | 2000 |
Differences in the antiischaemic effects of molsidomine and isosorbide dinitrate.
Topics: Coronary Disease; Hemodynamics; Humans; Isosorbide Dinitrate; Molsidomine | 1992 |
[Modification of thrombocyte function in diagnostic and therapeutic interventions in cardiology].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Coronary Disease; Dose-Response Relationship, Drug; Double- | 1991 |
[Acute and chronic effects of molsidomine in therapeutic coronary angioplasty].
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease; Delayed-Action Preparations; | 1990 |
[Gallopamil and molsidomine in patients with coronary heart disease. A comparative study].
Topics: Clinical Trials as Topic; Coronary Disease; Electrocardiography; Exercise Test; Female; Gallopamil; | 1989 |
[Effect of vasodilator agents on the effectiveness of the complex treatment of patients with ischemic heart disease and congestive heart failure].
Topics: Aged; Cardiomyopathy, Dilated; Clinical Trials as Topic; Coronary Disease; Digoxin; Drug Synergism; | 1989 |
[Molsidomine in rest and exercise conditions in coronary heart disease. Acute and long-term effects].
Topics: Adult; Coronary Disease; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Long-Term Care; Middle | 1986 |
Preload or afterload reduction: which is more beneficial for patients with ischemic heart disease?
Topics: Coronary Disease; Female; Hemodynamics; Humans; Male; Middle Aged; Molsidomine; Nifedipine; Random A | 1988 |
[Treatment of stress-induced angina pectoris and chronic heart failure with molsidomine].
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Exercise Test; Hea | 1986 |
[Acute and long-term effects of placebo and molsidomine on pulmonary artery pressure and on workload in patients with coronary heart disease].
Topics: Adult; Blood Pressure; Coronary Disease; Exercise Test; Humans; Male; Middle Aged; Molsidomine; Plac | 1986 |
Hemodynamic effects of molsidomine, isosorbide dinitrate, and nifedipine at rest and during exercise.
Topics: Adult; Blood Pressure; Coronary Disease; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Mid | 1985 |
Exercise tolerance in coronary patients: randomized trial of two-week treatment with molsidomine versus placebo.
Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Exercise Test; Female; | 1985 |
Pharmacokinetics of an extended-release dosage form of molsidomine in patients with coronary heart disease.
Topics: Aged; Angina Pectoris; Biological Availability; Clinical Trials as Topic; Coronary Disease; Double-B | 1985 |
[Use of molsidomine in patients with coronary disease].
Topics: Adult; Clinical Trials as Topic; Coronary Disease; Humans; Male; Middle Aged; Molsidomine; Oxadiazol | 1985 |
[Effectiveness and duration of effect of molsidomine and isosorbide dinitrate in peripheral circulation].
Topics: Aged; Arterial Occlusive Diseases; Clinical Trials as Topic; Coronary Disease; Female; Hemodynamics; | 1985 |
66 other studies available for molsidomine and Coronary Heart Disease
Article | Year |
---|---|
[Effects of molsidomine during the cold test in stable coronary insufficiency under beta-blocker treatment].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cold Temperature; Coronary Disease; Hemodynamics; Humans; | 1984 |
[Clinical evaluation of molsidomin in ischemic cardiopathy].
Topics: Aged; Coronary Disease; Drug Evaluation; Female; Humans; Male; Middle Aged; Molsidomine; Oxadiazoles | 1984 |
[Redistribution of the coronary blood flow, functional improvement of the ischemic myocardium and reduction of the size of an experimental infarction by molsidomine].
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Epoprostenol; Molsidomine; Oxadiazoles; Oxyge | 1983 |
[Molsidomin in coronary disease. Clinico-pharmacokinetic correlation study on the effect of oral and sublingual therapy].
Topics: Administration, Oral; Adult; Angina Pectoris; Coronary Disease; Double-Blind Method; Humans; Kinetic | 1983 |
[Cellular mechanism of action of molsidomine. Bioinduction of prostacyclin].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cells, Cultured; Coronary Disease; Epoprostenol; Molsidomine; | 1983 |
[Treatment with sidnonimine derivatives of chronic ischemic heart disease patients].
Topics: Angina Pectoris; Arrhythmias, Cardiac; Chronic Disease; Coronary Disease; Drug Evaluation; Female; H | 1984 |
Anti-ischemic effects of molsidomine in an experimental model of coronary artery stenosis.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Coronary Disease; Dogs; Electrocardiography; Femal | 1983 |
Effects of molsidomine on exercise tolerance in patients with coronary heart disease.
Topics: Aged; Coronary Disease; Double-Blind Method; Humans; Male; Middle Aged; Molsidomine; Oxadiazoles; Ox | 1983 |
[Interactions between digoxin and amiodarone (Cordarone), verapamil (Isoptin) and melsidomine (Corvatone)].
Topics: Adult; Amiodarone; Cardiotonic Agents; Coronary Disease; Digoxin; Drug Interactions; Humans; Male; M | 1983 |
[Hemodynamic and coronary effects of molsidomine in patients with stable coronary insufficiency in the basal state, during an atrial stimulation test and a cold test].
Topics: Adult; Aged; Atrial Function; Cold Temperature; Coronary Circulation; Coronary Disease; Electric Sti | 1983 |
[Molsidomine, a coronary drug with platelet-aggregating inhibitory activity].
Topics: Angina Pectoris; Blood Pressure; Coronary Disease; Epoprostenol; Female; Humans; Male; Molsidomine; | 1982 |
[Therapy of coronary heart disease with molsidomine].
Topics: Angina Pectoris; Coronary Disease; Electrocardiography; Humans; Male; Middle Aged; Molsidomine; Morp | 1981 |
The effect of some antianginal drugs on the myocardial perfusion in patients with ischaemic heart disease.
Topics: Adult; Angina Pectoris; Coronary Circulation; Coronary Disease; Coronary Vessels; Delayed-Action Pre | 1981 |
Effect of molsidomine on coronary collateral blood flow in acute myocardial ischemia.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Hemodynamics; Male; Molsidomine; Morp | 1980 |
[The effect of molsidomine on left ventricular function in coronary heart disease (author's transl)].
Topics: Adult; Angina Pectoris; Blood Pressure; Cardiac Volume; Computers; Coronary Disease; Female; Heart; | 1980 |
Hemodynamic effects of molsidomine at rest and during submaximal and maximal exercise in patients with coronary artery disease limited by exertional angina pectoris.
Topics: Adult; Angina Pectoris; Cardiac Output; Coronary Disease; Exercise Test; Heart Rate; Hemodynamics; H | 1981 |
[Effect of molsidomine on cardiac function in experimental transitory coronary insufficiency].
Topics: Acute Disease; Animals; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Female; Heart; Male; M | 1981 |
Effects of molsidomine on coronary artery thrombosis and myocardial ischemia in acute canine experiments.
Topics: Animals; Blood Coagulation; Coronary Disease; Disease Models, Animal; Dogs; Female; Hemodynamics; Ma | 1981 |
[Effect of molsidomine on hemodynamics and myocardial ischemia in patients with acute myocardial infarction (author's transl)].
Topics: Administration, Oral; Blood Pressure; Cardiac Output; Coronary Disease; Heart Rate; Hemodynamics; Hu | 1982 |
Reduction of occlusive coronary artery thrombosis and myocardial ischemia by molsidomine in anesthetized dogs.
Topics: Animals; Blood Pressure; Coronary Disease; Dogs; Electric Stimulation; Electrocardiography; Female; | 1982 |
Intracoronary linsidomine abolishes acetylcholine-induced vasoconstriction of epicardial coronary arteries.
Topics: Acetylcholine; Coronary Circulation; Coronary Disease; Coronary Vessels; Dose-Response Relationship, | 1993 |
Cultured endothelial cells restore vasodilator responses to coronary arteries with impaired endothelial function and alter the response to a nitric oxide donor.
Topics: Animals; Arginine; Blood Flow Velocity; Calcimycin; Cells, Cultured; Coronary Circulation; Coronary | 1994 |
[Effects of intravenous administration of nitroglycerin and SIN-1 or molsidomine on epicardial arterial diameter in patients with stable coronary heart disease].
Topics: Coronary Circulation; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedu | 1994 |
[Is there a drug interaction between heparin and molsidomine?].
Topics: Adult; Aged; Coronary Disease; Drug Interactions; Drug Therapy, Combination; Female; Heparin; Humans | 1994 |
[Molsidomine and bladder cancer: is there a connection?].
Topics: Aged; Coronary Disease; Humans; Male; Molsidomine; Time Factors; Urinary Bladder Neoplasms | 1993 |
[Hemodynamic effect of molsidomine in coronary patients with heart failure with clinically manifest nitrate tolerance].
Topics: Aged; Coronary Disease; Drug Therapy, Combination; Drug Tolerance; Female; Heart Failure; Hemodynami | 1993 |
Standardization of coronary vasomotor tone with intracoronary nitroglycerin.
Topics: Blood Pressure; Calcium Channel Blockers; Case-Control Studies; Coronary Angiography; Coronary Disea | 1996 |
Clinical pharmacokinetics of molsidomine.
Topics: Absorption; Administration, Oral; Age Factors; Angina Pectoris; Coronary Disease; Humans; Injections | 1996 |
[Clinical use of molsidomine in the treatment of patients with coronary artery diseases].
Topics: Coronary Disease; Humans; Molsidomine; Vasodilator Agents | 1996 |
[Influence of combination therapy (isosorbide dinitrate and molsidomine) on the incidence of angina pectoris in patients with coronary heart disease].
Topics: Aged; Angina Pectoris; Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, Dr | 1997 |
Gastroepiploic bypass graft stenting.
Topics: Angina, Unstable; Arteries; Coronary Artery Bypass; Coronary Disease; Graft Occlusion, Vascular; Hum | 1999 |
[Erectile dysfunction. Help also for cardiac patients].
Topics: Apomorphine; Contraindications; Coronary Disease; Drug Interactions; Erectile Dysfunction; Humans; M | 2001 |
Cardioprotection by molsidomine and iloprost in myocardial ischemia in anaesthetized cats.
Topics: Animals; Blood Platelets; Blood Pressure; Cats; Coronary Disease; Coronary Vessels; Cyclic GMP; Elec | 1992 |
Hemodynamic response to molsidomine in patients with ischemic cardiomyopathy tolerant to isosorbide dinitrate.
Topics: Aged; Animals; Cardiomyopathy, Dilated; Coronary Disease; Drug Tolerance; Female; Hemodynamics; Huma | 1991 |
[Inhibition of thrombocyte function in coronary heart disease. Results with molsidomine (Corvaton)].
Topics: Blood Platelets; Coronary Disease; Humans; Molsidomine | 1991 |
[Effect of molsidomine on thrombocyte aggregation in unstable angina pectoris after parenteral administration of nitroglycerin].
Topics: Angina, Unstable; Coronary Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hum | 1991 |
Acute hemodynamic effects of molsidomine in patients with ischemic cardiomyopathy.
Topics: Adult; Aged; Coronary Disease; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Molsi | 1991 |
Torsades de pointes after intracoronary papaverine.
Topics: Angioplasty, Balloon, Coronary; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Electro | 1991 |
Reproducible uniform coronary vasomotor tone with nitrocompounds: prerequisite of quantitative coronary angiographic trials.
Topics: Angiography; Coronary Angiography; Coronary Disease; Female; Humans; Image Interpretation, Computer- | 1990 |
Coronary vasodilation with nitrocompounds--is there a maximum?
Topics: Administration, Sublingual; Adult; Aged; Coronary Circulation; Coronary Disease; Dose-Response Relat | 1989 |
[Hemodynamic and medicamentous modification of stimulated atrial natriuretic factor secretion].
Topics: Adult; Aged; Atenolol; Atrial Natriuretic Factor; Blood Pressure; Cardiac Catheterization; Cardiac P | 1989 |
Comparison of haemodynamic effects of nifedipine and molsidomine in patients with coronary artery disease.
Topics: Adult; Aged; Coronary Disease; Female; Hemodynamics; Humans; Male; Middle Aged; Molsidomine; Nifedip | 1989 |
[The effect of molsidomine on the conjunctival microcirculation in patients with ischemic heart disease].
Topics: Adult; Aged; Angina Pectoris; Conjunctiva; Coronary Disease; Drug Evaluation; Female; Humans; Male; | 1989 |
[Effect of molsidomine preparations on the contractile function of the myocardium and coronary circulation in patients with ischemic heart disease complicated by heart failure after isometric load].
Topics: Administration, Oral; Administration, Sublingual; Adult; Aged; Cardiomyopathy, Dilated; Coronary Cir | 1989 |
[Various aspects of drug therapy of chronic forms of ischemic heart disease].
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Angina Pectoris; Calcium Channel Block | 1985 |
[Antiaggregants of thrombocytes in ischemic heart disease].
Topics: Adrenergic beta-Antagonists; Aspirin; Coronary Disease; Dipyridamole; Fibrinolytic Agents; Humans; M | 1985 |
The pharmacologic management of coronary artery disease in 1986.
Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Calcium Channel Blockers; Coronary Disease | 1986 |
[Substituted sydnonimines: hemodynamic effects and distribution of coronary blood flow in normal and ischemic myocardium].
Topics: Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Coronary Disease; Depression, Chemica | 1985 |
[Anti-ischemic effects of SIN-1, a molsidomine metabolite, during coronary angioplasty and antiplatelet effects in humans].
Topics: Adenosine Triphosphate; Administration, Oral; Angioplasty, Balloon; Coronary Disease; Coronary Vesse | 1988 |
Interactions of vasodilators with calcium entry- and beta-blockers in patients with coronary heart disease.
Topics: Bupranolol; Calcium Channel Blockers; Coronary Disease; Drug Interactions; Drug Therapy, Combination | 1986 |
[Problems in acute therapy of coronary heart disease using drugs that reduce preload and afterload].
Topics: Coronary Disease; Heart Failure; Hemodynamics; Humans; Hypertension; Molsidomine; Nifedipine; Nitrog | 1987 |
[Problems in long-term therapy of coronary heart disease: pharmacotherapy].
Topics: Angina Pectoris; Coronary Disease; Humans; Long-Term Care; Molsidomine | 1987 |
[Ex vivo study of blood platelet activation in healthy subjects or coronary disease patients after oral intake of molsidomine].
Topics: Administration, Oral; Adult; Blood Platelets; Coronary Disease; Female; Humans; Male; Molsidomine; P | 1987 |
Long-acting coronary vasodilatory action of the molsidomine metabolite Sin 1: a quantitative angiographic study.
Topics: Coronary Angiography; Coronary Disease; Coronary Vessels; Humans; Injections, Intra-Arterial; Molsid | 1987 |
[The importance of Lopion (molsidomine) in the therapy of myocardial ischemia and angina pectoris].
Topics: Angina Pectoris; Coronary Disease; Exercise Test; Humans; Middle Aged; Molsidomine | 1987 |
Acute and chronic effects of molsidomine on pulmonary artery pressure and work capacity in patients with coronary heart disease.
Topics: Adult; Blood Pressure; Coronary Disease; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Male; | 1987 |
[We need molsidomine for complete prevention of ischemia. Interview with Prof. Rudolph on the therapy of coronary heart disease].
Topics: Coronary Disease; Drug Therapy, Combination; Humans; Molsidomine; Oxadiazoles; Sydnones; Vasodilator | 1986 |
Molsidomine prevents post-ischaemic ventricular fibrillation in dogs.
Topics: Adenosine Diphosphate; Animals; Arrhythmias, Cardiac; Cardiac Output; Coronary Disease; Dogs; Electr | 1986 |
[Biorhythm influence on the course of ischemic heart disease during combined treatment with molsidomine and anaprilin].
Topics: Angina Pectoris; Coronary Disease; Drug Therapy, Combination; Emergencies; Humans; Molsidomine; Peri | 1986 |
Proceedings of the International Symposium on Molsidomine. November 5, 1983, Brussels, Belgium.
Topics: Coronary Disease; Heart Failure; Humans; Molsidomine; Oxadiazoles; Sydnones; Vasodilator Agents | 1985 |
Pharmacokinetics of molsidomine in humans.
Topics: Animals; Biological Availability; Coronary Disease; Dogs; Half-Life; Humans; Kinetics; Molsidomine; | 1985 |
Effects of molsidomine on regional contraction and global function of the left ventricle.
Topics: Adult; Coronary Disease; Exercise Test; Female; Heart Ventricles; Humans; Male; Metoprolol; Middle A | 1985 |
The effect of molsidomine on intramyocardial pressure and regional myocardial blood flow in the canine ischemic myocardium.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Dogs; Heart; Kinetics; Molsidomine; | 1985 |
Haemodynamic effects of molsidomine in patients with severe chronic coronary disease.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Coronary Circulation; Coronary Disease; Electric Stimu | 1985 |
Hemodynamic effects of molsidomine on weight sustaining isometric exercise in patients with ischemic heart disease.
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Female; Heart Rate; Hemodynamics; Humans; Isometric C | 1985 |
[Relation between therapeutic efficacy of antianginal preparations in patients with ischemic heart disease and their effect on the rheologic properties of blood].
Topics: Adult; Amiodarone; Benzofurans; Blood Coagulation; Blood Viscosity; Coronary Disease; Erythrocyte Ag | 1985 |