molsidomine has been researched along with Cirrhosis, Liver in 11 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2 [34-67] years) with cirrhosis of the liver of various aetiologies to determine whether molsidomine, which selectively reduces pre-load with-out the development of tolerance, effects portal and cardiac haemodynamics in liver cirrhosis and portal hypertension." | 7.68 | [The effect of molsidomine on portal and cardiac hemodynamics in liver cirrhosis]. ( Barmeyer, J; Hüppe, D; Jäger, D; May, B; Tromm, A; Tunn, S, 1991) |
| " Since nitration of tyrosine residues occurs in a range of diseases involving inflammation, we tested the hypothesis that nitration of specific proteins could result in apoptosis of hepatic stellate cells (HSC), the primary cellular source of matrix components in liver diseases." | 3.77 | Apoptosis of hepatic stellate cells mediated by specific protein nitration. ( Domingo de Miguel, E; Iraburu, MJ; López-Zabalza, MJ; Mòdol, T; Natal, C; Pérez de Obanos, MP, 2011) |
| "2 [34-67] years) with cirrhosis of the liver of various aetiologies to determine whether molsidomine, which selectively reduces pre-load with-out the development of tolerance, effects portal and cardiac haemodynamics in liver cirrhosis and portal hypertension." | 3.68 | [The effect of molsidomine on portal and cardiac hemodynamics in liver cirrhosis]. ( Barmeyer, J; Hüppe, D; Jäger, D; May, B; Tromm, A; Tunn, S, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (72.73) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Urtasun, R | 1 |
| Cubero, FJ | 1 |
| Vera, M | 1 |
| Nieto, N | 1 |
| Mòdol, T | 1 |
| Natal, C | 1 |
| Pérez de Obanos, MP | 1 |
| Domingo de Miguel, E | 1 |
| Iraburu, MJ | 1 |
| López-Zabalza, MJ | 1 |
| May, B | 4 |
| Hüppe, D | 2 |
| Jäger, D | 2 |
| Tromm, A | 2 |
| Barmeyer, J | 2 |
| Eberl, T | 1 |
| Barnert, J | 1 |
| Wienbeck, M | 1 |
| Wang, Y | 1 |
| Gu, C | 1 |
| García-Pagán, JC | 2 |
| Escorsell, A | 1 |
| Feu, F | 2 |
| Bandi, JC | 1 |
| Moitinho, E | 1 |
| Casado, M | 1 |
| Bosch, J | 2 |
| Rodés, J | 2 |
| Abdallahi, OM | 1 |
| Bensalem, H | 1 |
| Diagana, M | 1 |
| De Reggi, M | 1 |
| Gharib, B | 1 |
| Ruiz del Arbol, L | 1 |
| Pizcueta, MP | 1 |
| Tunn, S | 1 |
1 review available for molsidomine and Cirrhosis, Liver
| Article | Year |
|---|---|
[Nitric oxide and hyperdynamic circulation in liver cirrhosis].
Topics: Animals; Humans; Hypertension, Portal; Liver Cirrhosis; Liver Cirrhosis, Experimental; Molsidomine; | 1995 |
2 trials available for molsidomine and Cirrhosis, Liver
| Article | Year |
|---|---|
Propranolol plus molsidomine vs propranolol alone in the treatment of portal hypertension in patients with cirrhosis.
Topics: Adult; Blood Pressure; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypertension, Portal | 1996 |
Effects of molsidomine, a long acting venous dilator, on portal hypertension. A hemodynamic study in patients with cirrhosis.
Topics: Adult; Aged; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Hemodynamics; He | 1991 |
8 other studies available for molsidomine and Cirrhosis, Liver
| Article | Year |
|---|---|
Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Cell Proliferation; Cells, Cultured; Co | 2009 |
Apoptosis of hepatic stellate cells mediated by specific protein nitration.
Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Cell Line; DNA Fragmentation; Hepatic Stellate Cells; Huma | 2011 |
[Non-cardiac indications for administration of molsidomine. Introduction].
Topics: Esophageal Achalasia; Esophageal Spasm, Diffuse; Humans; Hypertension, Portal; Liver Cirrhosis; Mols | 1994 |
[Dose-dependent acute effect and long-term modification by molsidomine of portal and cardiac hemodynamics in patients with liver cirrhosis].
Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Esophageal and Gastric | 1994 |
[Can the molsidomine effect on portal pressure in liver cirrhosis be augmented by increasing the dose?].
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, In | 1994 |
[Non-cardiac indications for administration of molsidomine. Conclusions/perspectives].
Topics: Esophageal Motility Disorders; Humans; Hypertension, Portal; Liver Cirrhosis; Molsidomine; Portal Pr | 1994 |
Inhibition of nitric oxide synthase activity reduces liver injury in murine schistosomiasis.
Topics: Animals; Arginine; Enzyme Inhibitors; Female; Hydroxyproline; Lipid Peroxides; Liver; Liver Cirrhosi | 2001 |
[The effect of molsidomine on portal and cardiac hemodynamics in liver cirrhosis].
Topics: Adult; Aged; Female; Heart; Hemodynamics; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; Live | 1991 |