molsidomine has been researched along with Cerebral Ischemia in 13 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the authors examined the effects of treatment with the NO donor molsidomine with regard to decreasing the incidence of spasm-related delayed brain infarctions and improving clinical outcome in patients with SAH." | 7.83 | Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study. ( Brüning, R; Ehlert, A; Heindel, W; Hesselmann, V; Jacobs, AH; Manthei, G; Pluta, RM; Ringelstein, EB; Schmidt, C; Stummer, W; Wölfer, J, 2016) |
| " In this study, the authors examined the effects of treatment with the NO donor molsidomine with regard to decreasing the incidence of spasm-related delayed brain infarctions and improving clinical outcome in patients with SAH." | 3.83 | Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study. ( Brüning, R; Ehlert, A; Heindel, W; Hesselmann, V; Jacobs, AH; Manthei, G; Pluta, RM; Ringelstein, EB; Schmidt, C; Stummer, W; Wölfer, J, 2016) |
| "Delayed cerebral ischemia (DCI) occurred only during loose, low-dose or interrupted treatment (17% vs." | 1.56 | Nitric Oxide-Based Treatment of Poor-Grade Patients After Severe Aneurysmal Subarachnoid Hemorrhage. ( Ehlert, A; Ehlert-Gamm, A; Flack, J; Gerss, J; Gessert, M; Hesselmann, V; Manthei, G; Starekova, J, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 8 (61.54) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Ehlert, A | 2 |
| Starekova, J | 1 |
| Manthei, G | 2 |
| Ehlert-Gamm, A | 1 |
| Flack, J | 1 |
| Gessert, M | 1 |
| Gerss, J | 1 |
| Hesselmann, V | 2 |
| Schmidt, C | 1 |
| Wölfer, J | 1 |
| Jacobs, AH | 1 |
| Brüning, R | 1 |
| Heindel, W | 1 |
| Ringelstein, EB | 1 |
| Stummer, W | 1 |
| Pluta, RM | 1 |
| Coert, BA | 1 |
| Anderson, RE | 1 |
| Meyer, FB | 1 |
| Ju, C | 2 |
| Oh, YJ | 1 |
| Han, BH | 1 |
| Kim, HS | 1 |
| Kim, HC | 2 |
| Kim, WK | 2 |
| Wen, TC | 2 |
| Rogido, MR | 1 |
| Moore, JE | 1 |
| Genetta, T | 1 |
| Peng, H | 2 |
| Sola, A | 1 |
| Choi, JW | 3 |
| Yoo, BK | 1 |
| Ryu, MK | 2 |
| Choi, MS | 2 |
| Park, GH | 2 |
| Ko, KH | 3 |
| Yoo, oK | 1 |
| Jeon, MJ | 1 |
| Kaundal, RK | 1 |
| Shah, KK | 1 |
| Sharma, SS | 1 |
| Zhang, F | 2 |
| Iadecola, C | 2 |
| White, JG | 1 |
| Tanaka, J | 1 |
| Maeda, N | 1 |
| Matsuda, S | 1 |
| Desaki, J | 1 |
| Sudo, S | 1 |
| Zhang, B | 1 |
| Sakanaka, M | 1 |
| Bastianetto, S | 1 |
| Zheng, WH | 1 |
| Quirion, R | 1 |
| Shin, CY | 1 |
| Jang, ES | 1 |
| Choi, CR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Statin Therapy To Limit Cognitive Dysfunction After Cardiac Surgery[NCT01186289] | 0 participants (Actual) | Interventional | 2010-10-31 | Withdrawn (stopped due to Principal Investigator decided not to pursue enrollment due to changes in standard of care.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for molsidomine and Cerebral Ischemia
| Article | Year |
|---|---|
Nitric Oxide-Based Treatment of Poor-Grade Patients After Severe Aneurysmal Subarachnoid Hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Brain Ischemia; Feasibility Studies; Female; Hum | 2020 |
Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Infarction; Brain Ischemia; Drug Therapy, Combinat | 2016 |
Effects of the nitric oxide donor 3-morpholinosydnonimine (SIN-1) in focal cerebral ischemia dependent on intracellular brain pH.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Hydrogen | 2002 |
Intracellular pH-dependent peroxynitrite-evoked synergistic death of glucose-deprived astrocytes.
Topics: Amiloride; Ammonium Chloride; Anaerobiosis; Animals; Astrocytes; Brain Ischemia; Caspases; Cyclospor | 2004 |
Cardiotrophin-1 protects cortical neuronal cells against free radical-induced injuries in vitro.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cerebral Infarctio | 2005 |
Adenosine and purine nucleosides prevent the disruption of mitochondrial transmembrane potential by peroxynitrite in rat primary astrocytes.
Topics: Adenosine; Animals; Astrocytes; Brain Ischemia; Cell Survival; Cells, Cultured; Dose-Response Relati | 2005 |
Mitogen-activated protein kinases (MAPKs) mediate SIN-1/ glucose deprivation-induced death in rat primary astrocytes.
Topics: Adenosine Triphosphate; Animals; Anthracenes; Astrocytes; Brain Ischemia; Cell Culture Techniques; C | 2005 |
Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cell Survival; Disease Models, Animal; DNA Fragmentation; | 2006 |
Reduction of focal cerebral ischemic damage by delayed treatment with nitric oxide donors.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroencephalography; Male; Molsidomi | 1994 |
Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; | 1994 |
Epidermal growth factor protects neuronal cells in vivo and in vitro against transient forebrain ischemia- and free radical-induced injuries.
Topics: Animals; Apoptosis; Avoidance Learning; Brain Ischemia; Cells, Cultured; DNA Fragmentation; Epiderma | 1998 |
The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C.
Topics: Alkaloids; Alzheimer Disease; Animals; Antioxidants; Azoles; Benzophenanthridines; Brain Ischemia; C | 2000 |
Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose.
Topics: Adjuvants, Immunologic; Animals; Astrocytes; Brain; Brain Ischemia; Cell Death; Cytokines; Dehydroep | 2001 |