molsidomine has been researched along with Cardiomegaly in 3 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested the hypothesis that increasing myocardial cyclic GMP levels would reduce myocardial O2 consumption and that renal hypertension (One Kidney-One Clip, 1K1C)-induced cardiac hypertrophy would change this relationship." | 7.69 | Negative metabolic effects of cyclic GMP are altered in renal hypertension induced cardiac hypertrophy. ( Naim, KL; Rabindranauth, P; Sadoff, JD; Scholz, PM; Tse, J; Weiss, HR, 1997) |
| "We tested the hypothesis that increasing myocardial cyclic GMP would attenuate cyclic AMP induced positive inotropy and O2 consumption, in part, through changes in cyclic AMP and that renal hypertension-induced cardiac hypertrophy (HYP) would alter this relationship." | 3.70 | Cyclic GMP attenuates cyclic AMP-stimulated inotropy and oxygen consumption in control and hypertrophic hearts. ( Leone, RJ; Scholz, PM; Straznicka, M; Weiss, HR, 2000) |
| "We tested the hypothesis that increasing myocardial cyclic GMP levels would reduce myocardial O2 consumption and that renal hypertension (One Kidney-One Clip, 1K1C)-induced cardiac hypertrophy would change this relationship." | 3.69 | Negative metabolic effects of cyclic GMP are altered in renal hypertension induced cardiac hypertrophy. ( Naim, KL; Rabindranauth, P; Sadoff, JD; Scholz, PM; Tse, J; Weiss, HR, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rabindranauth, P | 1 |
| Naim, KL | 1 |
| Scholz, PM | 2 |
| Tse, J | 1 |
| Sadoff, JD | 1 |
| Weiss, HR | 2 |
| Ritchie, RH | 1 |
| Schiebinger, RJ | 1 |
| LaPointe, MC | 1 |
| Marsh, JD | 1 |
| Leone, RJ | 1 |
| Straznicka, M | 1 |
3 other studies available for molsidomine and Cardiomegaly
| Article | Year |
|---|---|
Negative metabolic effects of cyclic GMP are altered in renal hypertension induced cardiac hypertrophy.
Topics: Animals; Blood Gas Analysis; Cardiomegaly; Coronary Circulation; Cyclic GMP; Enzyme Inhibitors; Guan | 1997 |
Angiotensin II-induced hypertrophy of adult rat cardiomyocytes is blocked by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Animals; Bradyk | 1998 |
Cyclic GMP attenuates cyclic AMP-stimulated inotropy and oxygen consumption in control and hypertrophic hearts.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Isoproterenol; Molsidomine; Myoca | 2000 |