molsidomine has been researched along with Blood Clot in 14 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Antithrombotic effects of molsidomine, isosorbide dinitrate and verapamil obtained from the Casela Riedel Pharma GmbH, Frankfurt/Main, Germany have been studied in the laser-induced rat thrombosis model." | 7.68 | [Antithrombotic effects of molsidomine, isosorbide dinitrate and verapamil in a laser-induced thrombosis model]. ( Bielawiec, M; Breddin, H; Krupiński, K, 1993) |
| "The antithrombotic effects of the stable PGI2-analogue Cicaprost, acetylsalicylic acid (Aspisol), the low molecular weight heparin CY 216 (Fraxiparin) and Molsidomin (Corvaton) have been investigated alone and in combinations in a thrombosis model in rats in which mesenteric venules with a diameter of 20-30 microns were injured by defined argon laser lesions." | 7.68 | Effects of combinations of a prostacyclin analogue (Cicaprost) with different antithrombotic agents in a rat microcirculatory thrombosis model. ( Breddin, HK; Giedrojc, J, 1992) |
| "Defibrotide, acetylsalicylic acid, low molecular weight heparin (CY 216), sodium heparin, Molsidomin and a thromboxane receptor antagonist have been investigated separately and in combinations in an animal thrombosis model in which rat mesenteric venules are damaged by defined laser energy." | 7.68 | Anticoagulant and antithrombotic effects of combinations of defibrotide with heparins and other antithrombotic agents in an animal thrombosis model. ( Breddin, HK; Giedrojc, J, 1991) |
| "Antithrombotic effects of molsidomine, isosorbide dinitrate and verapamil obtained from the Casela Riedel Pharma GmbH, Frankfurt/Main, Germany have been studied in the laser-induced rat thrombosis model." | 3.68 | [Antithrombotic effects of molsidomine, isosorbide dinitrate and verapamil in a laser-induced thrombosis model]. ( Bielawiec, M; Breddin, H; Krupiński, K, 1993) |
| "The antithrombotic effects of the stable PGI2-analogue Cicaprost, acetylsalicylic acid (Aspisol), the low molecular weight heparin CY 216 (Fraxiparin) and Molsidomin (Corvaton) have been investigated alone and in combinations in a thrombosis model in rats in which mesenteric venules with a diameter of 20-30 microns were injured by defined argon laser lesions." | 3.68 | Effects of combinations of a prostacyclin analogue (Cicaprost) with different antithrombotic agents in a rat microcirculatory thrombosis model. ( Breddin, HK; Giedrojc, J, 1992) |
| "Defibrotide, acetylsalicylic acid, low molecular weight heparin (CY 216), sodium heparin, Molsidomin and a thromboxane receptor antagonist have been investigated separately and in combinations in an animal thrombosis model in which rat mesenteric venules are damaged by defined laser energy." | 3.68 | Anticoagulant and antithrombotic effects of combinations of defibrotide with heparins and other antithrombotic agents in an animal thrombosis model. ( Breddin, HK; Giedrojc, J, 1991) |
| "The activity of nafazatrom and molsidomine, two antithrombotic drugs claimed to increase prostacycline level, was investigated in an electrically-induced carotid thrombosis model in the conscious rat." | 3.67 | Investigations on the role of arachidonic acid metabolism pathways in the antithrombotic activity of nafazatrom and molsidomine. ( Boulu, RG; Massad, L; Plotkine, M, 1988) |
| "Molsidomine and SIN-1 were tested in a thrombosis model in which thrombi are produced in small mesenteric vessels." | 3.67 | [Inhibition of the formation of platelet thrombus by molsidomine and SIN-1 in the mesenteric vessels rats]. ( Breddin, HK; Weichert, W, 1987) |
| "However, it enhanced the inhibition of thrombus formation by RE 2047 from 9% to 17% (5 + 5 mg/kg) or 19% to 27% (10 + 10 mg/kg) in arterioles." | 1.30 | Interaction of Viagra with the NO donors molsidomine and RE 2047 with regard to antithrombotic and blood pressure lowering activities. ( Rehse, K; Reitner, N; Scheffler, H, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 9 (64.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weichert, W | 3 |
| Pauliks, V | 1 |
| Breddin, HK | 5 |
| Gryglewski, RJ | 1 |
| Swies, J | 1 |
| Faxon, DP | 1 |
| Currier, JW | 1 |
| Krupiński, K | 1 |
| Breddin, H | 1 |
| Bielawiec, M | 1 |
| Rehse, K | 1 |
| Scheffler, H | 1 |
| Reitner, N | 1 |
| Giedrojc, J | 3 |
| Sinzinger, H | 1 |
| Rauscha, F | 1 |
| O'Grady, J | 1 |
| Fitscha, P | 1 |
| Bassenge, E | 1 |
| Massad, L | 1 |
| Plotkine, M | 1 |
| Boulu, RG | 1 |
| Just, M | 1 |
| Martorana, PA | 1 |
| Nitz, RE | 1 |
| Grodzinska, L | 1 |
| Basista, M | 1 |
| Koenig, E | 1 |
2 reviews available for molsidomine and Blood Clot
| Article | Year |
|---|---|
Prevention of post-PTCA restenosis.
Topics: Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Arterial Occlusive Disease | 1995 |
[Inhibition of platelet activation by endothelium-derived relaxing factor EDRF/NO and NO releasing dilator substances].
Topics: Animals; Arteriosclerosis; Humans; Molsidomine; Nitric Oxide; Platelet Aggregation; Thrombosis; Vaso | 1991 |
2 trials available for molsidomine and Blood Clot
| Article | Year |
|---|---|
Prevention of post-PTCA restenosis.
Topics: Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Arterial Occlusive Disease | 1995 |
Prostaglandin I2 and the nitric oxide donor molsidomine have synergistic effects on thromboresistance in man.
Topics: Aged; Drug Synergism; Epoprostenol; Female; Humans; Male; Middle Aged; Molsidomine; Thrombosis | 1992 |
11 other studies available for molsidomine and Blood Clot
| Article | Year |
|---|---|
Laser-induced thrombi in rat mesenteric vessels and antithrombotic drugs.
Topics: Animals; Aspirin; Blood Platelets; Dipyridamole; Disease Models, Animal; Fibrinolytic Agents; Hepari | 1983 |
Streptokinase-prostacyclin--nitric oxide: in vivo interactions.
Topics: Animals; Arginine; Aspirin; Blood Pressure; Cats; Epoprostenol; Extracorporeal Circulation; Fibrinol | 1995 |
[Antithrombotic effects of molsidomine, isosorbide dinitrate and verapamil in a laser-induced thrombosis model].
Topics: Animals; Dose-Response Relationship, Drug; Isosorbide Dinitrate; Lasers; Male; Mesenteric Arteries; | 1993 |
Interaction of Viagra with the NO donors molsidomine and RE 2047 with regard to antithrombotic and blood pressure lowering activities.
Topics: Animals; Arterioles; Blood Pressure; Drug Interactions; Fibrinolytic Agents; Hypertension; Molsidomi | 1999 |
Effects of combinations of a prostacyclin analogue (Cicaprost) with different antithrombotic agents in a rat microcirculatory thrombosis model.
Topics: Animals; Aspirin; Drug Synergism; Drug Therapy, Combination; Epoprostenol; Fibrinolytic Agents; Hepa | 1992 |
[Antithrombotic effects of molsidomine alone and in combination with other antithrombotic agents in a thrombosis model of the microcirculation of the rat].
Topics: Animals; Disaccharides; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epoprostenol; F | 1991 |
Anticoagulant and antithrombotic effects of combinations of defibrotide with heparins and other antithrombotic agents in an animal thrombosis model.
Topics: Animals; Anticoagulants; Aspirin; Blood Coagulation; Drug Interactions; Fibrinolytic Agents; Heparin | 1991 |
Investigations on the role of arachidonic acid metabolism pathways in the antithrombotic activity of nafazatrom and molsidomine.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Epoprostenol; Fibrinolytic Agents; Male; Molsidomine; | 1988 |
[Inhibition of the formation of platelet thrombus by molsidomine and SIN-1 in the mesenteric vessels rats].
Topics: Animals; Arterioles; Male; Mesenteric Vascular Occlusion; Molsidomine; Rats; Thrombosis; Venules | 1987 |
[Inhibition of platelet functions by molsidomine in animals].
Topics: Animals; Blood Platelets; Hemostasis; Molsidomine; Platelet Aggregation; Thrombosis | 1987 |
[Antithrombotic properties of the active metabolite of molsidomine, SIN-1].
Topics: Animals; Delayed-Action Preparations; Fibrinolysis; Humans; Molsidomine; Rabbits; Thrombosis | 1987 |