molsidomine has been researched along with Arteriosclerosis in 14 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This is a short-term action and the dosage is limited by systemic hypotension." | 2.38 | [Endothelial factors and thrombocyte function]. ( Schrör, K, 1991) |
| "Treatment with molsidomine (1 mg/kg/day) during cholesterol withdrawal did not affect plaque size but increased the thickness of the subendothelial macrophage-free layer consisting of SMC, and normalized both superoxide production and ecSOD mRNA expression." | 1.32 | Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability during cholesterol lowering in rabbits. ( Bult, H; De Cleen, DM; De Meyer, GR; Herman, AG; Knaapen, MW; Kockx, MM; Martinet, W, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 9 (64.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rabelo, LA | 1 |
| Cortes, SF | 1 |
| Alvarez-Leite, JI | 1 |
| Lemos, VS | 1 |
| De Meyer, GR | 3 |
| Kockx, MM | 1 |
| Knaapen, MW | 1 |
| Martinet, W | 1 |
| De Cleen, DM | 1 |
| Bult, H | 3 |
| Herman, AG | 3 |
| Kienbaum, P | 1 |
| Braun, M | 1 |
| Hohlfeld, T | 1 |
| Weber, AA | 1 |
| Sarbia, M | 1 |
| Schrör, K | 2 |
| Moore, KP | 1 |
| Darley-Usmar, V | 1 |
| Morrow, J | 1 |
| Roberts, LJ | 1 |
| Upmacis, RK | 1 |
| Deeb, RS | 1 |
| Hajjar, DP | 1 |
| Guy, RA | 1 |
| Maguire, GF | 1 |
| Crandall, I | 1 |
| Connelly, PW | 1 |
| Kain, KC | 1 |
| Rolland, PH | 1 |
| Bartoli, JM | 1 |
| Piquet, P | 1 |
| Mekkaoui, C | 1 |
| Nott, SH | 1 |
| Moulin, G | 1 |
| Amabile, P | 1 |
| Mesana, T | 1 |
| Bassenge, E | 1 |
| Sinzinger, H | 1 |
| Gryglewski, RJ | 1 |
| Bieroń, K | 1 |
| Dembińska-Kieć, A | 1 |
| Kostka-Trabka, E | 1 |
| Zembowicz, A | 1 |
| Daune, M | 1 |
| Quarre, JP | 1 |
| Michalakis, G | 1 |
| Courtoy, JF | 1 |
2 reviews available for molsidomine and Arteriosclerosis
| Article | Year |
|---|---|
[Inhibition of platelet activation by endothelium-derived relaxing factor EDRF/NO and NO releasing dilator substances].
Topics: Animals; Arteriosclerosis; Humans; Molsidomine; Nitric Oxide; Platelet Aggregation; Thrombosis; Vaso | 1991 |
[Endothelial factors and thrombocyte function].
Topics: Animals; Arteriosclerosis; Blood Platelets; Endothelium, Vascular; Epoprostenol; Humans; Molsidomine | 1991 |
1 trial available for molsidomine and Arteriosclerosis
| Article | Year |
|---|---|
[Synergism of PGI2 and molsidomine in arterial occlusive disease].
Topics: Arterial Occlusive Diseases; Arteriosclerosis; Coronary Thrombosis; Drug Synergism; Drug Therapy, Co | 1991 |
11 other studies available for molsidomine and Arteriosclerosis
| Article | Year |
|---|---|
Endothelium dysfunction in LDL receptor knockout mice: a role for H2O2.
Topics: Acetylcholine; Amitrole; Animals; Aorta, Thoracic; Arteriosclerosis; Catalase; Endothelium; Endothel | 2003 |
Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability during cholesterol lowering in rabbits.
Topics: Acetonitriles; Animals; Aorta; Apoptosis; Arteriosclerosis; Body Weight; Cholesterol; Cholesterol, D | 2003 |
Antiatherosclerotic effects of oral naftidrofuryl in cholesterol-fed rabbits involve inhibition of neutrophil function.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; C | 1995 |
Influence of chronic treatment with a nitric oxide donor on fatty streak development and reactivity of the rabbit aorta.
Topics: Acetylcholine; Animals; Aorta; Aortic Diseases; Arteriosclerosis; Body Weight; Cholesterol; Dietary | 1995 |
Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite.
Topics: Antihypertensive Agents; Arachidonic Acid; Arteriosclerosis; Catalysis; Humans; In Vitro Techniques; | 1995 |
Regulation of prostaglandin H2 synthase activity by nitrogen oxides.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cells, Cultured; Cyclooxygenase 1; Enzyme Activation; En | 1999 |
Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36.
Topics: Animals; Arteriosclerosis; CD36 Antigens; CHO Cells; Copper; Cricetinae; Electrophoresis, Agar Gel; | 2001 |
Local delivery of NO-donor molsidomine post-PTA improves haemodynamics, wall mechanics and histomorphometry in atherosclerotic porcine SFA.
Topics: Administration, Cutaneous; Angioplasty, Balloon; Animals; Arteriosclerosis; Combined Modality Therap | 2002 |
Early atherosclerosis is accompanied by a decreased rather than an increased accumulation of fatty acid hydroxyderivatives.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cholesterol; Chromatography, High Pressure Liquid; Hydro | 1991 |
Interaction between prostacyclin and molsidomine in blood cells and plasma.
Topics: Aged; Animals; Arteriosclerosis; Drug Synergism; Epoprostenol; Fibrinolytic Agents; Humans; In Vitro | 1991 |
[Unstable angina: recent findings and therapeutic applications].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Anticoagulants; Arteriosclerosis; Ca | 1987 |