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molsidomine and Anoxemia

molsidomine has been researched along with Anoxemia in 20 studies

Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.

Research Excerpts

ExcerptRelevanceReference
"The present study addressed whether combined treatment with a phosphodiesterase type 5 inhibitor, sildenafil, and a nitric oxide donor, molsidomine, prevents development of pulmonary hypertension in chronic hypoxic rats."7.73Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats. ( Andersen, CU; Mulvany, MJ; Simonsen, U, 2005)
"To explore endothelium-dependent relaxation and the L-arginine (L-ARG)-nitric oxide (NO) pathway during chronic hypoxia, we examined isolated rings from large conduit pulmonary arteries and aorta from rats exposed to either room air (N), 3-week hypoxia (H), or 3-week H followed by 72-h recovery to normoxia (room air)."7.68Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine. ( Adnot, S; Blouquit, Y; Carville, C; Eddahibi, S; Raffestin, B, 1993)
"The present study addressed whether combined treatment with a phosphodiesterase type 5 inhibitor, sildenafil, and a nitric oxide donor, molsidomine, prevents development of pulmonary hypertension in chronic hypoxic rats."3.73Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats. ( Andersen, CU; Mulvany, MJ; Simonsen, U, 2005)
"To this end, we determined pulmonary prostacyclin synthase (PGIS) gene expression, circulating levels of the stable prostacyclin metabolite 6-keto prostaglandin F(1alpha) (6-keto-PGF(1alpha)), pulmonary endothelin (ET)-1 gene expression, and ET-1 plasma levels in rats exposed to 4 weeks of hypoxia (10% O(2)) in the presence or absence of either the nitric oxide (NO) donor molsidomine (MD, 15 mg/kg/day) or the ET-A receptor antagonist LU135252 (LU, 50 mg/kg/day)."3.71Increased pulmonary prostacyclin synthesis in rats with chronic hypoxic pulmonary hypertension. ( Blumberg, FC; Lorenz, C; Pfeifer, M; Riegger, GA; Sandner, P; Wolf, K, 2002)
" The aims of this study were to investigate the effects of potassium (K+) channel blockers and the nitric oxide (NO) synthase inhibitor, L-nitroarginine (L-NOARG), on the response produced by acute hypoxia in rat intrapulmonary artery rings in vitro."3.70Effect of K+ channel blocking drugs and nitric oxide synthase inhibition on the response to hypoxia in rat pulmonary artery rings. ( Kane, KA; Karamsetty, MR; Wadsworth, RM, 1998)
"Renal gene expression of PDGF-A and PDGF-B was neither affected by 2 or 4 weeks of hypoxia nor by concomitant treatment with LU135252 or molsidomine."3.70Effects of chronic hypoxia on renal PDGF-A, PDGF-B, and VEGF gene expression in rats. ( Blumberg, FC; Holmer, SR; Krämer, BK; Nabel, C; Pfeifer, M; Riegger, GA; Schweda, A; Schweda, F, 2000)
"To explore endothelium-dependent relaxation and the L-arginine (L-ARG)-nitric oxide (NO) pathway during chronic hypoxia, we examined isolated rings from large conduit pulmonary arteries and aorta from rats exposed to either room air (N), 3-week hypoxia (H), or 3-week H followed by 72-h recovery to normoxia (room air)."3.68Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine. ( Adnot, S; Blouquit, Y; Carville, C; Eddahibi, S; Raffestin, B, 1993)
" In both dogfish and eel, AD dose-response curves showed a biphasic effect: vasoconstriction (pico to nanomolar range) and vasodilation (micromolar range)."1.33Adenosine/nitric oxide crosstalk in the branchial circulation of Squalus acanthias and Anguilla anguilla. ( Pellegrino, D; Randall, DJ; Tota, B, 2005)
"4."1.32The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats. ( de Dam, MY; Elmedal, B; Mulvany, MJ; Simonsen, U, 2004)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's7 (35.00)18.2507
2000's12 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Elmedal, B1
de Dam, MY1
Mulvany, MJ2
Simonsen, U2
Andersen, CU1
Pellegrino, D1
Tota, B1
Randall, DJ1
Schwenke, DO3
Pearson, JT3
Tsuchimochi, H1
Mori, H2
Shirai, M3
Kangawa, K1
Carville, C1
Raffestin, B1
Eddahibi, S1
Blouquit, Y1
Adnot, S1
Yang, XP1
Wang, FX1
Ren, DC1
Lu, SC1
Fu, SX1
Li, YS1
Schlüter, KD1
Jakob, G1
Ruiz-Meana, M1
Garcia-Dorado, D1
Piper, HM1
Huang, YC1
Fisher, PW1
Nozik-Grayck, E1
Piantadosi, CA1
Karamsetty, MR1
Wadsworth, RM1
Kane, KA1
Schweda, F2
Blumberg, FC4
Schweda, A2
Kammerl, M1
Holmer, SR2
Riegger, GA4
Pfeifer, M4
Krämer, BK2
Berkenbosch, JW2
Baribeau, J2
Perreault, T2
Nabel, C1
Wolf, K2
Sandner, P2
Lorenz, C2
Barrington, KJ1
Decker, ER1
Wu, C1
Brock, TA1
Gaál, J1
Vértesi, C2
Knopf, E2
Körmöczy, PS2
Leitold, M1
Hader, S1

Other Studies

20 other studies available for molsidomine and Anoxemia

ArticleYear
The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats.
    British journal of pharmacology, 2004, Volume: 141, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Administration, O

2004
Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats.
    European journal of pharmacology, 2005, Mar-07, Volume: 510, Issue:1-2

    Topics: Acetylcholine; Actins; Animals; Atrial Natriuretic Factor; Body Weight; Dose-Response Relationship,

2005
Adenosine/nitric oxide crosstalk in the branchial circulation of Squalus acanthias and Anguilla anguilla.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2005, Volume: 142, Issue:2

    Topics: Adenosine; Anguilla; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Female; Hypoxia; In Vitr

2005
Exogenous nitric oxide centrally enhances pulmonary reactivity in the normal and hypertensive rat.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:11

    Topics: Animals; Blood Pressure; Cardiac Output; Central Nervous System; Heart Rate; Hypertension, Pulmonary

2005
Does central nitric oxide elicit pulmonary hypertension in conscious rats?
    Respiratory physiology & neurobiology, 2006, Oct-27, Volume: 153, Issue:3

    Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Blood Pressure; Enzyme Inhibitors; Heart Ra

2006
Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats?
    Acta physiologica (Oxford, England), 2006, Volume: 186, Issue:4

    Topics: Acute Disease; Animals; Central Nervous System; Cerebral Ventricles; Hypoxia; Male; Molsidomine; NG-

2006
Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:6

    Topics: Acetylcholine; Animals; Arginine; Calcimycin; Endothelins; Endothelium, Vascular; Hypoxia; In Vitro

1993
Effects of 3-morpholinosydnonimine-N-ethylcarbamide on hypoxia-induced mechanical and electric responses of isolated pig coronary artery.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995, Volume: 16, Issue:6

    Topics: Animals; Coronary Vessels; Hypoxia; In Vitro Techniques; Membrane Potentials; Molsidomine; Muscle Re

1995
Protection of reoxygenated cardiomyocytes against osmotic fragility by nitric oxide donors.
    The American journal of physiology, 1996, Volume: 271, Issue:2 Pt 2

    Topics: Animals; Antioxidants; Diacetyl; Enzyme Activation; Guanylate Cyclase; Hypoxia; Male; Molsidomine; M

1996
Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 1

    Topics: Animals; Arginine; Blood Pressure; Hypoxia; In Vitro Techniques; Lung; Male; Microcirculation; Molsi

1997
Effect of K+ channel blocking drugs and nitric oxide synthase inhibition on the response to hypoxia in rat pulmonary artery rings.
    Journal of autonomic pharmacology, 1998, Volume: 18, Issue:1

    Topics: Animals; Cell Hypoxia; Endothelium, Vascular; Enzyme Inhibitors; Hypoxia; In Vitro Techniques; Male;

1998
Effects of chronic hypoxia on renal renin gene expression in rats.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:1

    Topics: Animals; Blood Pressure; Chronic Disease; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-

2000
Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 278, Issue:2

    Topics: Animals; Animals, Newborn; Arginine; Blood Vessels; Cyclic GMP; Hypertension, Pulmonary; Hypoxia; In

2000
Effects of chronic hypoxia on renal PDGF-A, PDGF-B, and VEGF gene expression in rats.
    Nephron, 2000, Volume: 86, Issue:2

    Topics: Animals; Chronic Disease; Endothelial Growth Factors; Endothelin Receptor Antagonists; Gene Expressi

2000
The NO donor molsidomine reduces endothelin-1 gene expression in chronic hypoxic rat lungs.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 280, Issue:2

    Topics: Animals; Chronic Disease; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Gene Expression R

2001
TBC3711, an ET(A) receptor antagonist, reduces neonatal hypoxia-induced pulmonary hypertension in piglets.
    Pediatric research, 2001, Volume: 50, Issue:3

    Topics: Animals; Animals, Newborn; Cell Line; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hyperte

2001
Increased pulmonary prostacyclin synthesis in rats with chronic hypoxic pulmonary hypertension.
    Cardiovascular research, 2002, Volume: 55, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Chronic Disease; Cytochrome P-450 Enzyme System; Endothelin R

2002
Comparison of the cardioprotective effect of nitroglycerin, molsidomine and SIN-1 in rats with cardiac hypoxia.
    Acta physiologica Hungarica, 1990, Volume: 75 Suppl

    Topics: Animals; Antihypertensive Agents; Heart Diseases; Hypoxia; Molsidomine; Nitroglycerin; Rats

1990
Effect of nitroglycerin and a nitroglycerin-like substance in isoprenaline (ISO) necrosis and hypoxia.
    Acta physiologica Hungarica, 1990, Volume: 75 Suppl

    Topics: Animals; Hypoxia; Isoproterenol; Molsidomine; Necrosis; Nitroglycerin; Rats

1990
[Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat].
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:10

    Topics: Administration, Oral; Angina Pectoris; Animals; Coronary Vasospasm; Electrocardiography; Hypoxia; Is

1986