molsidomine has been researched along with Anoxemia in 20 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study addressed whether combined treatment with a phosphodiesterase type 5 inhibitor, sildenafil, and a nitric oxide donor, molsidomine, prevents development of pulmonary hypertension in chronic hypoxic rats." | 7.73 | Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats. ( Andersen, CU; Mulvany, MJ; Simonsen, U, 2005) |
| "To explore endothelium-dependent relaxation and the L-arginine (L-ARG)-nitric oxide (NO) pathway during chronic hypoxia, we examined isolated rings from large conduit pulmonary arteries and aorta from rats exposed to either room air (N), 3-week hypoxia (H), or 3-week H followed by 72-h recovery to normoxia (room air)." | 7.68 | Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine. ( Adnot, S; Blouquit, Y; Carville, C; Eddahibi, S; Raffestin, B, 1993) |
| "The present study addressed whether combined treatment with a phosphodiesterase type 5 inhibitor, sildenafil, and a nitric oxide donor, molsidomine, prevents development of pulmonary hypertension in chronic hypoxic rats." | 3.73 | Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats. ( Andersen, CU; Mulvany, MJ; Simonsen, U, 2005) |
| "To this end, we determined pulmonary prostacyclin synthase (PGIS) gene expression, circulating levels of the stable prostacyclin metabolite 6-keto prostaglandin F(1alpha) (6-keto-PGF(1alpha)), pulmonary endothelin (ET)-1 gene expression, and ET-1 plasma levels in rats exposed to 4 weeks of hypoxia (10% O(2)) in the presence or absence of either the nitric oxide (NO) donor molsidomine (MD, 15 mg/kg/day) or the ET-A receptor antagonist LU135252 (LU, 50 mg/kg/day)." | 3.71 | Increased pulmonary prostacyclin synthesis in rats with chronic hypoxic pulmonary hypertension. ( Blumberg, FC; Lorenz, C; Pfeifer, M; Riegger, GA; Sandner, P; Wolf, K, 2002) |
| " The aims of this study were to investigate the effects of potassium (K+) channel blockers and the nitric oxide (NO) synthase inhibitor, L-nitroarginine (L-NOARG), on the response produced by acute hypoxia in rat intrapulmonary artery rings in vitro." | 3.70 | Effect of K+ channel blocking drugs and nitric oxide synthase inhibition on the response to hypoxia in rat pulmonary artery rings. ( Kane, KA; Karamsetty, MR; Wadsworth, RM, 1998) |
| "Renal gene expression of PDGF-A and PDGF-B was neither affected by 2 or 4 weeks of hypoxia nor by concomitant treatment with LU135252 or molsidomine." | 3.70 | Effects of chronic hypoxia on renal PDGF-A, PDGF-B, and VEGF gene expression in rats. ( Blumberg, FC; Holmer, SR; Krämer, BK; Nabel, C; Pfeifer, M; Riegger, GA; Schweda, A; Schweda, F, 2000) |
| "To explore endothelium-dependent relaxation and the L-arginine (L-ARG)-nitric oxide (NO) pathway during chronic hypoxia, we examined isolated rings from large conduit pulmonary arteries and aorta from rats exposed to either room air (N), 3-week hypoxia (H), or 3-week H followed by 72-h recovery to normoxia (room air)." | 3.68 | Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine. ( Adnot, S; Blouquit, Y; Carville, C; Eddahibi, S; Raffestin, B, 1993) |
| " In both dogfish and eel, AD dose-response curves showed a biphasic effect: vasoconstriction (pico to nanomolar range) and vasodilation (micromolar range)." | 1.33 | Adenosine/nitric oxide crosstalk in the branchial circulation of Squalus acanthias and Anguilla anguilla. ( Pellegrino, D; Randall, DJ; Tota, B, 2005) |
| "4." | 1.32 | The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats. ( de Dam, MY; Elmedal, B; Mulvany, MJ; Simonsen, U, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 12 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elmedal, B | 1 |
| de Dam, MY | 1 |
| Mulvany, MJ | 2 |
| Simonsen, U | 2 |
| Andersen, CU | 1 |
| Pellegrino, D | 1 |
| Tota, B | 1 |
| Randall, DJ | 1 |
| Schwenke, DO | 3 |
| Pearson, JT | 3 |
| Tsuchimochi, H | 1 |
| Mori, H | 2 |
| Shirai, M | 3 |
| Kangawa, K | 1 |
| Carville, C | 1 |
| Raffestin, B | 1 |
| Eddahibi, S | 1 |
| Blouquit, Y | 1 |
| Adnot, S | 1 |
| Yang, XP | 1 |
| Wang, FX | 1 |
| Ren, DC | 1 |
| Lu, SC | 1 |
| Fu, SX | 1 |
| Li, YS | 1 |
| Schlüter, KD | 1 |
| Jakob, G | 1 |
| Ruiz-Meana, M | 1 |
| Garcia-Dorado, D | 1 |
| Piper, HM | 1 |
| Huang, YC | 1 |
| Fisher, PW | 1 |
| Nozik-Grayck, E | 1 |
| Piantadosi, CA | 1 |
| Karamsetty, MR | 1 |
| Wadsworth, RM | 1 |
| Kane, KA | 1 |
| Schweda, F | 2 |
| Blumberg, FC | 4 |
| Schweda, A | 2 |
| Kammerl, M | 1 |
| Holmer, SR | 2 |
| Riegger, GA | 4 |
| Pfeifer, M | 4 |
| Krämer, BK | 2 |
| Berkenbosch, JW | 2 |
| Baribeau, J | 2 |
| Perreault, T | 2 |
| Nabel, C | 1 |
| Wolf, K | 2 |
| Sandner, P | 2 |
| Lorenz, C | 2 |
| Barrington, KJ | 1 |
| Decker, ER | 1 |
| Wu, C | 1 |
| Brock, TA | 1 |
| Gaál, J | 1 |
| Vértesi, C | 2 |
| Knopf, E | 2 |
| Körmöczy, PS | 2 |
| Leitold, M | 1 |
| Hader, S | 1 |
20 other studies available for molsidomine and Anoxemia
| Article | Year |
|---|---|
The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Administration, O | 2004 |
Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats.
Topics: Acetylcholine; Actins; Animals; Atrial Natriuretic Factor; Body Weight; Dose-Response Relationship, | 2005 |
Adenosine/nitric oxide crosstalk in the branchial circulation of Squalus acanthias and Anguilla anguilla.
Topics: Adenosine; Anguilla; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Female; Hypoxia; In Vitr | 2005 |
Exogenous nitric oxide centrally enhances pulmonary reactivity in the normal and hypertensive rat.
Topics: Animals; Blood Pressure; Cardiac Output; Central Nervous System; Heart Rate; Hypertension, Pulmonary | 2005 |
Does central nitric oxide elicit pulmonary hypertension in conscious rats?
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Blood Pressure; Enzyme Inhibitors; Heart Ra | 2006 |
Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats?
Topics: Acute Disease; Animals; Central Nervous System; Cerebral Ventricles; Hypoxia; Male; Molsidomine; NG- | 2006 |
Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine.
Topics: Acetylcholine; Animals; Arginine; Calcimycin; Endothelins; Endothelium, Vascular; Hypoxia; In Vitro | 1993 |
Effects of 3-morpholinosydnonimine-N-ethylcarbamide on hypoxia-induced mechanical and electric responses of isolated pig coronary artery.
Topics: Animals; Coronary Vessels; Hypoxia; In Vitro Techniques; Membrane Potentials; Molsidomine; Muscle Re | 1995 |
Protection of reoxygenated cardiomyocytes against osmotic fragility by nitric oxide donors.
Topics: Animals; Antioxidants; Diacetyl; Enzyme Activation; Guanylate Cyclase; Hypoxia; Male; Molsidomine; M | 1996 |
Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury.
Topics: Animals; Arginine; Blood Pressure; Hypoxia; In Vitro Techniques; Lung; Male; Microcirculation; Molsi | 1997 |
Effect of K+ channel blocking drugs and nitric oxide synthase inhibition on the response to hypoxia in rat pulmonary artery rings.
Topics: Animals; Cell Hypoxia; Endothelium, Vascular; Enzyme Inhibitors; Hypoxia; In Vitro Techniques; Male; | 1998 |
Effects of chronic hypoxia on renal renin gene expression in rats.
Topics: Animals; Blood Pressure; Chronic Disease; Endothelin Receptor Antagonists; Endothelin-1; Endothelin- | 2000 |
Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension.
Topics: Animals; Animals, Newborn; Arginine; Blood Vessels; Cyclic GMP; Hypertension, Pulmonary; Hypoxia; In | 2000 |
Effects of chronic hypoxia on renal PDGF-A, PDGF-B, and VEGF gene expression in rats.
Topics: Animals; Chronic Disease; Endothelial Growth Factors; Endothelin Receptor Antagonists; Gene Expressi | 2000 |
The NO donor molsidomine reduces endothelin-1 gene expression in chronic hypoxic rat lungs.
Topics: Animals; Chronic Disease; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Gene Expression R | 2001 |
TBC3711, an ET(A) receptor antagonist, reduces neonatal hypoxia-induced pulmonary hypertension in piglets.
Topics: Animals; Animals, Newborn; Cell Line; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hyperte | 2001 |
Increased pulmonary prostacyclin synthesis in rats with chronic hypoxic pulmonary hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Chronic Disease; Cytochrome P-450 Enzyme System; Endothelin R | 2002 |
Comparison of the cardioprotective effect of nitroglycerin, molsidomine and SIN-1 in rats with cardiac hypoxia.
Topics: Animals; Antihypertensive Agents; Heart Diseases; Hypoxia; Molsidomine; Nitroglycerin; Rats | 1990 |
Effect of nitroglycerin and a nitroglycerin-like substance in isoprenaline (ISO) necrosis and hypoxia.
Topics: Animals; Hypoxia; Isoproterenol; Molsidomine; Necrosis; Nitroglycerin; Rats | 1990 |
[Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat].
Topics: Administration, Oral; Angina Pectoris; Animals; Coronary Vasospasm; Electrocardiography; Hypoxia; Is | 1986 |