molsidomine has been researched along with Angina Pectoris in 96 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") formulation of molsidomine (16 mg) was evaluated in patients with stable angina pectoris." | 9.10 | A pilot double-blind randomized placebo-controlled study of molsidomine 16 mg once-a-day in patients suffering from stable angina pectoris: correlation between efficacy and over time plasma concentrations. ( Carreer-Bruhwyler, F; Chiap, P; Crommen, J; Dubois, C; Famaey, JP; Fenyvesi, T; Géczy, J; Hubert, P; Messin, R, 2003) |
| "Molsidomine is a derivative of the sydnonimines and is a long-acting vasodilator that may be effective in the treatment of chronic stable angina pectoris." | 9.05 | Long-term effects of molsidomine on exercise tolerance in patients with exertional angina pectoris. ( Kawaguchi, Y; Kawakita, S; Kinoshita, M; Motomura, M; Sawamura, M; Takayama, Y, 1983) |
| "In order to test the additional efficacy of the combination of a beta blocker (penbutolol 40 mg single dose) with molsidomine (2 mg single dose), a double blind cross-over trial was performed in 30 patients with stable angina pectoris." | 9.05 | Penbutolol and molsidomine synergism in angina pectoris. A double blind ergometric trial. ( Albera, HP; Balestrini, AE; Cabral, R; Feldman, R; Flichtentrei, D; Menzio, AC; Mercogliano, C; Vazquez, A, 1984) |
| "In a randomized controlled trial 31 patients, who were unsuccessfully being treated with metoprolol for severe angina pectoris, were also given molsidomine or placebo." | 9.05 | Combination of metoprolol with molsidomine in the treatment of angina pectoris. ( Lie, KI; Matroos, AW; van Mantgem, JP, 1985) |
| "Combination treatment with isosorbide dinitrate with molsidomine in a slow-release form (in the nitrate free interval) showed a distinct improvement in patients with angina pectoris refractory to treatment with reduction of complaints." | 7.69 | [Influence of combination therapy (isosorbide dinitrate and molsidomine) on the incidence of angina pectoris in patients with coronary heart disease]. ( Ciopor, M; Fischer, A; Hess, OM; Turina, J, 1997) |
| "The haemodynamic effects of a single dose of intravenous molsidomine were assessed in 12 patients with severe coronary disease." | 7.67 | Haemodynamic effects of molsidomine in patients with severe chronic coronary disease. ( Augé, JM; Bosch, X; Crexells, C; Garcia, J; Lidón, RM; Oriol, A; Pina, C, 1985) |
| "Heart rate (HR), cardiac output (CO), coronary sinus blood flow (CSF), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), mean arterial (MAP), and coronary arteriovenous difference for oxygen (AVDcO2) were measured in patients with stable angina pectoris without cardiac failure before and 40 to 60 minutes after administration of 2 or 3 mg of molsidomine." | 7.67 | Hemodynamic and coronary effects of molsidomine at basal state, during atrial pacing, and during cold pressor test in patients with stable angina pectoris. ( Dahan, M; Gourgon, R; Juliard, JM; Merillon, JP; Michel, PL; Neukirch, F; Pansard, Y; Zygelman, M, 1985) |
| "To analyze the mechanisms of action of molsidomine, a new antianginal drug, 10 patients with coronary artery disease and exertional angina pectoris were studied." | 7.66 | Hemodynamic effects of molsidomine at rest and during submaximal and maximal exercise in patients with coronary artery disease limited by exertional angina pectoris. ( Brasseur, LA; Cosyns, J; Detry, JM; Melin, J; Rousseau, MF, 1981) |
| "Both molsidomine formulations were effective in controlling patients' angina, did not induce any habituation and were well tolerated." | 6.71 | Efficacy and safety of molsidomine once-a-day in patients with stable angina pectoris. ( Carreer-Bruhwyler, F; Dubois, C; Famaey, JP; Fenyvesi, T; Géczy, J; Messin, R; Opolski, G, 2005) |
| "In patients with congestive heart failure, 1 hour after administration of 4 mg of molsidomine there were significant reductions in systolic and diastolic pulmonary artery pressures of 25% and 30%, respectively." | 6.66 | Effectiveness of molsidomine in the long-term treatment of exertional angina pectoris and chronic congestive heart failure. ( Dirschinger, J; Rudolph, W, 1985) |
| " Nitric oxide (NO) donors are used to treat patients with stable angina pectoris, and the aim of this study was to investigate the short- and long-term effect of molsidomine on the level of this circulating biochemical marker of endothelial function." | 5.11 | Long-term treatment with the NO-donor molsidomine reduces circulating ICAM-1 levels in patients with stable angina. ( Carreer-Bruhwyler, F; Géczy, J; Herman, AG; Van Hove, C, 2005) |
| ") formulation of molsidomine (16 mg) was evaluated in patients with stable angina pectoris." | 5.10 | A pilot double-blind randomized placebo-controlled study of molsidomine 16 mg once-a-day in patients suffering from stable angina pectoris: correlation between efficacy and over time plasma concentrations. ( Carreer-Bruhwyler, F; Chiap, P; Crommen, J; Dubois, C; Famaey, JP; Fenyvesi, T; Géczy, J; Hubert, P; Messin, R, 2003) |
| "In order to test the additional efficacy of the combination of a beta blocker (penbutolol 40 mg single dose) with molsidomine (2 mg single dose), a double blind cross-over trial was performed in 30 patients with stable angina pectoris." | 5.05 | Penbutolol and molsidomine synergism in angina pectoris. A double blind ergometric trial. ( Albera, HP; Balestrini, AE; Cabral, R; Feldman, R; Flichtentrei, D; Menzio, AC; Mercogliano, C; Vazquez, A, 1984) |
| "Studies of the efficacy of molsidomine, previously performed on our service, demonstrated that a clear antianginal effect in the longterm treatment of angina pectoris could only be achieved with a regimen of the standard 2 mg dose when given six times daily." | 5.05 | [Anti-ischemic effect of 8 mg molsidomin in retard form]. ( Blasini, R; Brügmann, U; Rudolph, W, 1984) |
| "Molsidomine was compared with propranolol for anti-anginal efficacy in a double-blind, cross-over, fixed-dose clinical trial, involving 39 patients with moderate, stable angina pectoris, and objective evidence of coronary sclerosis." | 5.05 | Molsidomine, an effective long-acting anti-anginal drug. ( Balakumaran, K; Chadha, DR; Hugenholtz, PG; Tijssen, JG, 1983) |
| " Cyclo-ergometric tests were used to evaluate the antianginal effects of molsidomine compared with a placebo administered to 5 ambulatory patients with stable angina pectoris." | 5.05 | The antianginal effect of molsidomine in prolonged oral therapy. A double blind, crossover, randomized study. ( Baudry, C, 1982) |
| "The effect of 2 mg sublingual molsidomine was evaluated in a double-blind cross-over study and compared to placebo in 9 patients with stable angina pectoris and ST-lowering of greater than or equal to 1 mm in the exercise ECG." | 5.05 | [Molsidomine in ergometric tests (author's transl)]. ( Lehmann, KH; Röhl, D, 1980) |
| "In a randomized controlled trial 31 patients, who were unsuccessfully being treated with metoprolol for severe angina pectoris, were also given molsidomine or placebo." | 5.05 | Combination of metoprolol with molsidomine in the treatment of angina pectoris. ( Lie, KI; Matroos, AW; van Mantgem, JP, 1985) |
| "Molsidomine is a derivative of the sydnonimines and is a long-acting vasodilator that may be effective in the treatment of chronic stable angina pectoris." | 5.05 | Long-term effects of molsidomine on exercise tolerance in patients with exertional angina pectoris. ( Kawaguchi, Y; Kawakita, S; Kinoshita, M; Motomura, M; Sawamura, M; Takayama, Y, 1983) |
| "The effectiveness of organic nitrates in the therapy of angina pectoris can be explained from their direct relaxing action on vascular smooth muscle." | 4.76 | [Effect of nitrates, nitrate-like substances, calcium antagonists and beta-adrenergic receptor blockers on peripheral circulation]. ( Bassenge, E; Busse, R, 1982) |
| "Combination treatment with isosorbide dinitrate with molsidomine in a slow-release form (in the nitrate free interval) showed a distinct improvement in patients with angina pectoris refractory to treatment with reduction of complaints." | 3.69 | [Influence of combination therapy (isosorbide dinitrate and molsidomine) on the incidence of angina pectoris in patients with coronary heart disease]. ( Ciopor, M; Fischer, A; Hess, OM; Turina, J, 1997) |
| "Nitrates, molsidomin, betablockers, calcium antagonists, inhibitors of platelet aggregation and anticoagulants are the most important drugs for the management of the different forms of angina pectoris." | 3.68 | [Anti-ischemia drug therapy]. ( Dubach, P; Ratti, R, 1991) |
| "Heart rate (HR), cardiac output (CO), coronary sinus blood flow (CSF), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), mean arterial (MAP), and coronary arteriovenous difference for oxygen (AVDcO2) were measured in patients with stable angina pectoris without cardiac failure before and 40 to 60 minutes after administration of 2 or 3 mg of molsidomine." | 3.67 | Hemodynamic and coronary effects of molsidomine at basal state, during atrial pacing, and during cold pressor test in patients with stable angina pectoris. ( Dahan, M; Gourgon, R; Juliard, JM; Merillon, JP; Michel, PL; Neukirch, F; Pansard, Y; Zygelman, M, 1985) |
| "The haemodynamic effects of a single dose of intravenous molsidomine were assessed in 12 patients with severe coronary disease." | 3.67 | Haemodynamic effects of molsidomine in patients with severe chronic coronary disease. ( Augé, JM; Bosch, X; Crexells, C; Garcia, J; Lidón, RM; Oriol, A; Pina, C, 1985) |
| "In the face of the recent introduction of beta-blockers and calcium inhibitors, the author examines the role of Amiodarone, Perhexiline and Molsidomine in the treatment of angina pectoris." | 3.66 | [The classic anti-anginal agents and molsidomine]. ( Vacheron, A, 1983) |
| "To analyze the mechanisms of action of molsidomine, a new antianginal drug, 10 patients with coronary artery disease and exertional angina pectoris were studied." | 3.66 | Hemodynamic effects of molsidomine at rest and during submaximal and maximal exercise in patients with coronary artery disease limited by exertional angina pectoris. ( Brasseur, LA; Cosyns, J; Detry, JM; Melin, J; Rousseau, MF, 1981) |
| ") on platelet function, on the plasma concentrations of 6-oxo-PGF1 alpha, the stable metabolite of prostaglandin I2, and thromboxane B2, the stable metabolite of thromboxine A2 was determined in ten patients with coronary heart disease." | 3.66 | [Molsidomine, a coronary drug with platelet-aggregating inhibitory activity]. ( Punzengruber, C; Silberbauer, K; Sinzinger, H; Slany, J, 1982) |
| "Both molsidomine formulations were effective in controlling patients' angina, did not induce any habituation and were well tolerated." | 2.71 | Efficacy and safety of molsidomine once-a-day in patients with stable angina pectoris. ( Carreer-Bruhwyler, F; Dubois, C; Famaey, JP; Fenyvesi, T; Géczy, J; Messin, R; Opolski, G, 2005) |
| " For ID, tolerance after long-term intake manifested in 7 out of 18 patients, for M--in 5 out of 18." | 2.68 | [Molsidomine and isosorbide dinitrate: a comparative trial of tolerance in long-term intake by IHD patients with stable angina of effort]. ( Alimova, EV; Kutishenko, NP; Martsevich, SIu; Metelitsa, VI, 1997) |
| "In patients with congestive heart failure, 1 hour after administration of 4 mg of molsidomine there were significant reductions in systolic and diastolic pulmonary artery pressures of 25% and 30%, respectively." | 2.66 | Effectiveness of molsidomine in the long-term treatment of exertional angina pectoris and chronic congestive heart failure. ( Dirschinger, J; Rudolph, W, 1985) |
| "Molsidomine seems to be a very promising drug for the treatment of effort and spontaneous angina." | 2.66 | Evaluation of the chronic antianginal effect of molsidomine. ( Dalla-Volta, S; Razzolini, R; Scorzelli, L, 1985) |
| "In 28 patients with unstable angina pectoris biplane coronary angiography was performed in the acute stage." | 2.65 | [Dynamics of critical stenosis in patients with unstable angina pectoris]. ( Karsch, KR; Niemczyk, P; Seipel, L; Voelker, W, 1984) |
| " The bioavailability of the parent compound after oral administration in tablet form is 44 to 59%, but further metabolism to release NO and form polar metabolites is rapid; the half-life (t-1/2) of SIN-1 is 1 to 2 hours." | 1.29 | Clinical pharmacokinetics of molsidomine. ( Parnham, MJ; Rosenkranz, B; Winkelmann, BR, 1996) |
| "Prolonged administration of nitroglycerin and its derivatives results in pharmacodynamic tolerance: although the dosage of these drugs is kept at the same level, their therapeutic effects decrease in amplitude." | 1.27 | [Comparative course of maintenance of the effects of nitrite derivatives and molsidomine after prolonged administration]. ( Degeorges, M; Weber, S, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 70 (72.92) | 18.7374 |
| 1990's | 17 (17.71) | 18.2507 |
| 2000's | 7 (7.29) | 29.6817 |
| 2010's | 2 (2.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Messin, R | 5 |
| Dubois, C | 3 |
| Famaey, JP | 3 |
| Hajlaoui, N | 1 |
| Tarragano, F | 1 |
| Raisky, P | 1 |
| Beaufils, P | 2 |
| Henry, P | 1 |
| Neumaier, J | 1 |
| Idrisova, EM | 1 |
| Kladieva, EA | 1 |
| Borovkova, NV | 1 |
| Vorob'eva, EV | 1 |
| Chernov, VI | 1 |
| Karpov, RS | 1 |
| Fenyvesi, T | 2 |
| Carreer-Bruhwyler, F | 3 |
| Crommen, J | 1 |
| Chiap, P | 1 |
| Hubert, P | 1 |
| Géczy, J | 4 |
| Opolski, G | 1 |
| Van Hove, C | 1 |
| Herman, AG | 2 |
| Witchitz, S | 5 |
| Kolsky, H | 3 |
| Moisson, P | 3 |
| Valette, H | 1 |
| Nishikawa, M | 1 |
| Kanamori, M | 1 |
| Hidaka, H | 1 |
| Busse, R | 1 |
| Bassenge, E | 2 |
| Gourgon, R | 2 |
| Russo-Marie, F | 1 |
| Nicolas, G | 2 |
| Berdeaux, A | 1 |
| Tartulier, M | 1 |
| Balestrini, AE | 1 |
| Menzio, AC | 1 |
| Cabral, R | 1 |
| Feldman, R | 1 |
| Mercogliano, C | 1 |
| Flichtentrei, D | 1 |
| Albera, HP | 1 |
| Vazquez, A | 2 |
| Blasini, R | 2 |
| Brügmann, U | 2 |
| Rudolph, W | 5 |
| Fach, WA | 1 |
| Becker, HJ | 1 |
| Strasser, R | 1 |
| Klepzig, H | 1 |
| Ostrowski, J | 2 |
| Resag, K | 2 |
| Vacheron, A | 3 |
| Balakumaran, K | 1 |
| Hugenholtz, PG | 1 |
| Tijssen, JG | 1 |
| Chadha, DR | 1 |
| Romano, M | 1 |
| de Caprio, L | 1 |
| Meccariello, P | 1 |
| Cuomo, S | 1 |
| Baldini, F | 1 |
| D'Ascia, C | 1 |
| Steinberg, G | 1 |
| Chiariello, M | 1 |
| Karsch, KR | 1 |
| Niemczyk, P | 1 |
| Voelker, W | 1 |
| Seipel, L | 1 |
| Vakaliuk, IP | 2 |
| Kuz'ko, NV | 1 |
| Bichan, NA | 1 |
| Gimeno, JV | 1 |
| Olagüe, J | 1 |
| Bueno, FJ | 1 |
| Tellols, R | 1 |
| Martín, G | 1 |
| Ferrer, J | 1 |
| Kinoshita, M | 1 |
| Sawamura, M | 1 |
| Motomura, M | 1 |
| Takayama, Y | 1 |
| Kawaguchi, Y | 1 |
| Kawakita, S | 1 |
| Silberbauer, K | 1 |
| Slany, J | 1 |
| Sinzinger, H | 1 |
| Punzengruber, C | 1 |
| Komarov, FI | 1 |
| Ol'binskaia, LI | 1 |
| Vartanova, OA | 1 |
| Bragina, GI | 1 |
| Ovchinnikova, LV | 1 |
| Lehmann, HU | 1 |
| Ziegler, G | 1 |
| Hochrein, H | 1 |
| Kaliman, J | 1 |
| Uhlir, H | 1 |
| Klicpera, M | 1 |
| Gasilin, VS | 1 |
| Kramer, AA | 1 |
| Samoilenko, LE | 1 |
| Beloev, I | 1 |
| Tomov, I | 1 |
| Elenkova, A | 1 |
| Terzieva, L | 1 |
| Mannes, A | 1 |
| Röhl, D | 1 |
| Lehmann, KH | 1 |
| Meyer, J | 1 |
| Sprauer, R | 1 |
| Krebs, W | 1 |
| Erbel, R | 1 |
| Schweizer, P | 1 |
| Effert, S | 1 |
| Detry, JM | 1 |
| Melin, J | 1 |
| Brasseur, LA | 1 |
| Cosyns, J | 1 |
| Rousseau, MF | 1 |
| Sauer, G | 1 |
| Tebbe, U | 1 |
| Krause, H | 1 |
| Kreuzer, H | 1 |
| Neuhaus, KL | 1 |
| Jasiński, K | 1 |
| Lukasik, S | 1 |
| Poprawski, K | 1 |
| Wrabec, K | 1 |
| Nowosad, H | 1 |
| Kargul, W | 1 |
| Baudry, C | 1 |
| Boxho, G | 1 |
| De Smedt, J | 1 |
| Buntinx, IM | 1 |
| Bult, H | 1 |
| Bosmans, JM | 1 |
| Vrints, CJ | 1 |
| Hug, J | 1 |
| Hasenfuss, G | 1 |
| Wollschläger, H | 1 |
| Just, HJ | 1 |
| Bonzel, T | 1 |
| Bultas, J | 1 |
| Karetová, D | 1 |
| Rotrekl, P | 2 |
| Vlasínová, J | 1 |
| Manousek, J | 1 |
| Semrád, B | 1 |
| Rysavý, F | 2 |
| Lupínek, Z | 2 |
| Meluzín, J | 2 |
| Vlasicová, I | 1 |
| Pirochtová, I | 1 |
| Bocek, O | 1 |
| Kukushkin, SK | 1 |
| Shamarin, VM | 1 |
| Manoshkina, EM | 1 |
| Berzak, NV | 1 |
| Petrosian, KIu | 1 |
| Rosenkranz, B | 1 |
| Winkelmann, BR | 1 |
| Parnham, MJ | 1 |
| Schächinger, V | 1 |
| Zeiher, AM | 1 |
| Karpov, Y | 1 |
| Baikova, N | 1 |
| Bruhwyler, J | 1 |
| Monseu, MJ | 1 |
| Guns, C | 1 |
| Ciopor, M | 1 |
| Fischer, A | 1 |
| Turina, J | 1 |
| Hess, OM | 1 |
| Alimova, EV | 1 |
| Martsevich, SIu | 2 |
| Kutishenko, NP | 1 |
| Metelitsa, VI | 2 |
| Le Feuvre, C | 2 |
| Le Quan Sang, KH | 2 |
| Brunet, A | 2 |
| Catuli, D | 1 |
| Metzger, JP | 2 |
| Devynck, MA | 2 |
| Maisch, B | 1 |
| Meinhardt, G | 1 |
| Sechtem, U | 1 |
| Pham, TD | 1 |
| Dubach, P | 1 |
| Ratti, R | 1 |
| Wagner, F | 1 |
| Gohlke-Bärwolf, C | 1 |
| Trenk, D | 1 |
| Jähnchen, E | 1 |
| Roskamm, H | 1 |
| Guy, JM | 1 |
| Lamaud, M | 1 |
| Duranton, B | 1 |
| Gerenton, C | 1 |
| Berthaud, T | 1 |
| Verneyre, H | 1 |
| Dirschinger, J | 2 |
| Beyerle, A | 2 |
| Brovko, EA | 1 |
| Denisiuk, VI | 1 |
| Kolesnik, PF | 1 |
| Bondarenko, IP | 1 |
| Tkachev, VA | 1 |
| Lupínková, Z | 1 |
| Kipshidze, NN | 1 |
| Chumburidze, VB | 1 |
| Kolski, H | 1 |
| Yvenou, L | 1 |
| Alpert, JS | 1 |
| Daune, M | 1 |
| Quarre, JP | 1 |
| Michalakis, G | 1 |
| Courtoy, JF | 1 |
| Leitold, M | 1 |
| Hader, S | 1 |
| Wautier, JL | 1 |
| Weber, S | 1 |
| Degeorges, M | 1 |
| Gilfrich, HJ | 1 |
| Borisov, AV | 1 |
| Ruano, J | 1 |
| Zueco, J | 1 |
| López, C | 1 |
| Colman, T | 1 |
| Arnau, C | 1 |
| Pajarón, A | 1 |
| Amsterdam, EA | 1 |
| Berkenboom, GM | 1 |
| Unger, P | 1 |
| Jottrand, M | 1 |
| Loiseau, J | 1 |
| Pype, F | 1 |
| Degre, SG | 1 |
| Weidemann, H | 1 |
| Schober, B | 1 |
| Schuon, J | 1 |
| Bory, M | 1 |
| Bourdarias, JP | 1 |
| Gilgenkrantz, JM | 1 |
| Guize, L | 1 |
| Letac, B | 1 |
| Sellier, P | 1 |
| Korabel'shchikova, NI | 3 |
| Bichko, MV | 3 |
| Rishko, NV | 3 |
| Maksimov, SD | 1 |
| Petrov, DV | 1 |
| Scuri, PM | 1 |
| Gavazzi, A | 1 |
| Falcone, C | 1 |
| Specchia, G | 1 |
| Montemartini, C | 1 |
| Trifunović, S | 1 |
| Pavlović, K | 1 |
| Juliard, JM | 1 |
| Neukirch, F | 1 |
| Zygelman, M | 1 |
| Merillon, JP | 1 |
| Michel, PL | 1 |
| Pansard, Y | 1 |
| Dahan, M | 1 |
| van Mantgem, JP | 1 |
| Lie, KI | 1 |
| Matroos, AW | 1 |
| González Juanatey, JR | 1 |
| Amaro Cendón, A | 1 |
| Rubio Alvarez, J | 1 |
| Gil de la Peña, M | 1 |
| Crexells, C | 1 |
| Lidón, RM | 1 |
| Augé, JM | 1 |
| Bosch, X | 1 |
| Pina, C | 1 |
| Garcia, J | 1 |
| Oriol, A | 1 |
| Combes, P | 1 |
| Richard, M | 1 |
| Fargnoli, JM | 1 |
| Malcolm, AD | 1 |
| De Backer, GG | 1 |
| Derese, A | 1 |
| Dalla-Volta, S | 1 |
| Scorzelli, L | 1 |
| Razzolini, R | 1 |
| Gaul, G | 1 |
| Voegele, D | 1 |
| Brockmeier, D | 1 |
| Mindlin de Aptecar, FR | 1 |
| Aptecar, M | 1 |
| Mroczek-Wójtowicz, J | 1 |
| Ilmurzyńska, K | 1 |
| Janik-Strobel, Z | 1 |
5 reviews available for molsidomine and Angina Pectoris
| Article | Year |
|---|---|
[Coronary spastic angina refractory to optimal medical therapy treated by angioplasty and stenting. A case report and review of literature].
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Coronary Vasospasm; Human | 2010 |
[Effect of nitrates, nitrate-like substances, calcium antagonists and beta-adrenergic receptor blockers on peripheral circulation].
Topics: Adrenergic beta-Antagonists; Amyl Nitrite; Angina Pectoris; Animals; Blood Circulation; Calcium Chan | 1982 |
[Nitric oxide in therapy of angina pectoris: nitrates or molsidomine?].
Topics: Angina Pectoris; Animals; Coronary Circulation; Drug Tolerance; Humans; Molsidomine; Nitrates; Nitri | 1997 |
[Treatment of myocardial ischemia with molsidomine].
Topics: Angina Pectoris; Coronary Disease; Electrocardiography; Humans; Molsidomine | 1990 |
[Role of molsidomine on platelet activation in coronary ischemia].
Topics: Angina Pectoris; Angina, Unstable; Humans; Molsidomine; Myocardial Infarction; Platelet Aggregation | 1988 |
41 trials available for molsidomine and Angina Pectoris
| Article | Year |
|---|---|
Comparative effects of once-daily molsidomine in coronary patients from two distinct European ethnicities.
Topics: Aged; Angina Pectoris; Blood Pressure; Delayed-Action Preparations; Demography; Double-Blind Method; | 2008 |
[Long-acting isosorbide dinitrate and molsidomin in the treatment of effort angina in patients with arterial hypotension].
Topics: Angina Pectoris; Humans; Isosorbide Dinitrate; Molsidomine; Muscle Hypotonia; Vasodilator Agents | 2002 |
A pilot double-blind randomized placebo-controlled study of molsidomine 16 mg once-a-day in patients suffering from stable angina pectoris: correlation between efficacy and over time plasma concentrations.
Topics: Aged; Angina Pectoris; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Exerci | 2003 |
Efficacy and safety of molsidomine once-a-day in patients with stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; | 2005 |
Long-term treatment with the NO-donor molsidomine reduces circulating ICAM-1 levels in patients with stable angina.
Topics: Angina Pectoris; Drug Administration Schedule; Female; Humans; Inflammation; Intercellular Adhesion | 2005 |
Penbutolol and molsidomine synergism in angina pectoris. A double blind ergometric trial.
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Drug Synergism; Drug Therapy, | 1984 |
[Anti-ischemic effect of 8 mg molsidomin in retard form].
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; D | 1984 |
[Effect duration and dose-response relation of molsidomine in patients with coronary heart disease].
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; D | 1984 |
Molsidomine, an effective long-acting anti-anginal drug.
Topics: Angina Pectoris; Clinical Trials as Topic; Headache; Heart Ventricles; Humans; Male; Molsidomine; Ni | 1983 |
Effects of long-term molsidomine treatment versus isosorbide dinitrate and placebo on exercise tolerance in stable angina.
Topics: Angina Pectoris; Coronary Disease; Electrocardiography; Exercise Test; Female; Hemodynamics; Humans; | 1984 |
[Dynamics of critical stenosis in patients with unstable angina pectoris].
Topics: Angina Pectoris; Angina, Unstable; Coronary Angiography; Coronary Circulation; Coronary Disease; Hem | 1984 |
Long-term effects of molsidomine on exercise tolerance in patients with exertional angina pectoris.
Topics: Aged; Angina Pectoris; Blood Pressure; Drug Tolerance; Electrocardiography; Exercise Test; Heart Rat | 1983 |
[Comparative examinations of the effectiveness of Molsidomin and nitrates in angina pectoris].
Topics: Angina Pectoris; Humans; Isosorbide Dinitrate; Molsidomine; Morpholines; Nitroglycerin; Oxadiazoles; | 1980 |
[Molsidomine in ergometric tests (author's transl)].
Topics: Angina Pectoris; Double-Blind Method; Exercise Test; Female; Half-Life; Humans; Male; Middle Aged; M | 1980 |
[Use of multicenter clinical trial of molsidomine by single-blind method in stable angina pectoris].
Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Molsidomine; Mo | 1981 |
The antianginal effect of molsidomine in prolonged oral therapy. A double blind, crossover, randomized study.
Topics: Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Heart Failure | 1982 |
Acute and chronic effect of molsidomine extended release on exercise capacity in patients with stable angina, a double-blind cross-over clinical trial versus placebo.
Topics: Acute Disease; Adult; Aged; Angina Pectoris; Blood Pressure; Chronic Disease; Cross-Over Studies; De | 1995 |
Isosorbidedinitrate and SIN-1 as dilators of human coronary arteries and platelet inhibitors.
Topics: Angina Pectoris; Blood Pressure; Coronary Vessels; Cyclic AMP; Cyclic GMP; Double-Blind Method; Fema | 1995 |
[Coronary dilatation after intracoronary administration of SIN-1 and intravenous molsidomine administration].
Topics: Adult; Aged; Angina Pectoris; Coronary Circulation; Coronary Disease; Coronary Vessels; Double-Blind | 1994 |
Short- and long-term effects of molsidomine retard and molsidomine nonretard on exercise capacity and clinical status in patients with stable angina: a multicenter randomized double-blind crossover placebo-controlled trial.
Topics: Adult; Aged; Angina Pectoris; Death, Sudden; Double-Blind Method; Electrocardiography; Exercise Test | 1998 |
[Molsidomine and isosorbide dinitrate: a comparative trial of tolerance in long-term intake by IHD patients with stable angina of effort].
Topics: Adult; Aged; Angina Pectoris; Coronary Angiography; Cross-Over Studies; Double-Blind Method; Electro | 1997 |
Differences in the antiischaemic effects of molsidomine and isosorbide dinitrate (ISDN) during acute and short-term administration in stable angina pectoris.
Topics: Angina Pectoris; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Drug Administrati | 1991 |
[Comparative study of the vasodilator properties of linsidomine chlorhydrate versus isosorbide dinitrate by the intracoronary route].
Topics: Adult; Aged; Angina Pectoris; Female; Humans; Injections, Intra-Arterial; Isosorbide Dinitrate; Male | 1991 |
[The effect of molsidomine on bicycle ergometry in patients with stable angina pectoris].
Topics: Adult; Angina Pectoris; Blood Pressure; Electrocardiography; Exercise Test; Humans; Isosorbide Dinit | 1989 |
[Randomized ergometric study of vasodilators combined with betablockaders].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Drug Therapy, C | 1986 |
[Molsidomine and isosorbide dinitrate:/their comparative effectiveness in patients with exertion-induced stenocardia].
Topics: Angina Pectoris; Clinical Trials as Topic; Humans; Isosorbide Dinitrate; Molsidomine; Physical Exert | 1988 |
An assessment of single doses of 8 mg sustained-release molsidomine using serial exercise tests.
Topics: Aged; Angina Pectoris; Delayed-Action Preparations; Exercise Test; Humans; Male; Middle Aged; Molsid | 1988 |
Exercise-induced angina alleviated by intracoronary SIN-1.
Topics: Adult; Aged; Angina Pectoris; Coronary Vessels; Exercise Test; Hemodynamics; Humans; Injections, Int | 1987 |
Comparative study of long-term effects of Molsidomin 8 mg (slow release form) and ISDN 40 mg (slow release form) on angina pectoris and ischaemic ST-segment depression during maximal bicycle-ergometry in patients with coronary insufficiency.
Topics: Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Exercise Tes | 1987 |
[Treatment of stress-induced angina pectoris and chronic heart failure with molsidomine].
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Exercise Test; Hea | 1986 |
[Treatment of unstable angina. A randomized double-blind study of propranolol, diltiazem and molsidomine].
Topics: Angina Pectoris; Angina, Unstable; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Female; | 1986 |
[Effectiveness of molsidomine in exertion angina pectoris: double-blind, randomized and placebo-controlled study].
Topics: Administration, Oral; Adult; Angina Pectoris; Double-Blind Method; Drug Evaluation; Humans; Male; Mi | 1987 |
Combination of metoprolol with molsidomine in the treatment of angina pectoris.
Topics: Aged; Angina Pectoris; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Metoprolol; | 1985 |
Effectiveness of molsidomine in the long-term treatment of exertional angina pectoris and chronic congestive heart failure.
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Drug Administration Schedule; Electrocard | 1985 |
Clinical and hemodynamic effects of the new dilator drug molsidomine.
Topics: Adult; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Exercise Test; Heart Rate; Hemodyn | 1985 |
Double-blind, randomized, placebo-controlled study of molsidomine in patients with stable effort angina receiving beta-blocker therapy with atenolol.
Topics: Adult; Aged; Angina Pectoris; Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Blind Metho | 1985 |
Evaluation of the chronic antianginal effect of molsidomine.
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Exercise Test; Female; Humans; Male; Middle Aged; M | 1985 |
[Rheological properties of blood in patients with stenocardia during treatment with obsidan, corvatone and corinfar].
Topics: Adult; Angina Pectoris; Blood Viscosity; Clinical Trials as Topic; Humans; Male; Middle Aged; Molsid | 1985 |
Pharmacokinetics of an extended-release dosage form of molsidomine in patients with coronary heart disease.
Topics: Aged; Angina Pectoris; Biological Availability; Clinical Trials as Topic; Coronary Disease; Double-B | 1985 |
Molsidomine--an effective antianginal drug. Results of an acute randomized stress-testing study.
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Humans; | 1985 |
[Corvaton in the treatment of unstable angina pectoris].
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Angina, Unstable; Clinical Trials as Topic; Fema | 1985 |
50 other studies available for molsidomine and Angina Pectoris
| Article | Year |
|---|---|
[From beta blocker to relaxation exercises. Prevention of angina pectoris attacks].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Exercise Therapy; Humans; Mo | 2011 |
[Ergometric study of a new vasodilator agent in angina: molsidomine. Value of combination with beta-blockaders].
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Drug Therapy, Combi | 1981 |
Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Angina Pectoris; Animals; | 1982 |
[A new family of anti-angina agents].
Topics: Angina Pectoris; Humans; Molsidomine; Oxadiazoles; Sydnones | 1983 |
[Molsidomin in coronary disease. Clinico-pharmacokinetic correlation study on the effect of oral and sublingual therapy].
Topics: Administration, Oral; Adult; Angina Pectoris; Coronary Disease; Double-Blind Method; Humans; Kinetic | 1983 |
[The classic anti-anginal agents and molsidomine].
Topics: Amiodarone; Angina Pectoris; Angina Pectoris, Variant; Humans; Kinetics; Molsidomine; Oxadiazoles; P | 1983 |
[Effectiveness of using corvaton on patients with unstable stenocardia].
Topics: Aged; Angina Pectoris; Angina, Unstable; Blood Viscosity; Conjunctiva; Dose-Response Relationship, D | 1984 |
[Treatment with sidnonimine derivatives of chronic ischemic heart disease patients].
Topics: Angina Pectoris; Arrhythmias, Cardiac; Chronic Disease; Coronary Disease; Drug Evaluation; Female; H | 1984 |
[Corvaton in the ambulatory treatment of patients with angina pectoris].
Topics: Adult; Ambulatory Care; Angina Pectoris; Humans; Male; Middle Aged; Molsidomine; Oxadiazoles; Sydnon | 1984 |
[Synergic action of molsidomine and atenolol in patients with exertion angina. Cycloergometric study].
Topics: Adult; Aged; Angina Pectoris; Atenolol; Blood Pressure; Drug Synergism; Heart Function Tests; Heart | 1984 |
[Molsidomine in exertion angina].
Topics: Angina Pectoris; Exercise Test; Hemodynamics; Humans; Isosorbide Dinitrate; Molsidomine; Nifedipine; | 1983 |
[Molsidomine, a coronary drug with platelet-aggregating inhibitory activity].
Topics: Angina Pectoris; Blood Pressure; Coronary Disease; Epoprostenol; Female; Humans; Male; Molsidomine; | 1982 |
[Comparative study of the anti-angina drug korvatone (molsidomin) and organic nitrates].
Topics: Adult; Aged; Angina Pectoris; Female; Humans; Male; Middle Aged; Molsidomine; Morpholines; Nitroglyc | 1980 |
[Therapy of coronary heart disease with molsidomine].
Topics: Angina Pectoris; Coronary Disease; Electrocardiography; Humans; Male; Middle Aged; Molsidomine; Morp | 1981 |
The effect of some antianginal drugs on the myocardial perfusion in patients with ischaemic heart disease.
Topics: Adult; Angina Pectoris; Coronary Circulation; Coronary Disease; Coronary Vessels; Delayed-Action Pre | 1981 |
[Clinical and hemodynamic effect of molsidomine in patients with unstable angina pectoris].
Topics: Angina Pectoris; Drug Therapy, Combination; Electrocardiography; Female; Hemodynamics; Humans; Male; | 1982 |
[Molsidomine in the long-term treatment of angina pectoris].
Topics: Angina Pectoris; Blood Pressure; Electrocardiography; Heart Rate; Humans; Long-Term Care; Molsidomin | 1982 |
[The effect of molsidomine on left ventricular function in coronary heart disease (author's transl)].
Topics: Adult; Angina Pectoris; Blood Pressure; Cardiac Volume; Computers; Coronary Disease; Female; Heart; | 1980 |
Hemodynamic effects of molsidomine at rest and during submaximal and maximal exercise in patients with coronary artery disease limited by exertional angina pectoris.
Topics: Adult; Angina Pectoris; Cardiac Output; Coronary Disease; Exercise Test; Heart Rate; Hemodynamics; H | 1981 |
[The effect of molsidomin on the arterial windkessel (author's transl)].
Topics: Angina Pectoris; Blood Pressure; Hemodynamics; Humans; Male; Middle Aged; Molsidomine; Morpholines; | 1981 |
[Pharmacological basis of therapy with molsidomine].
Topics: Angina Pectoris; Animals; Biological Availability; Coronary Vessels; Hemodynamics; Humans; Molsidomi | 1982 |
Does chronic nitrate therapy induce tolerance to short-acting ones?
Topics: Angina Pectoris; Drug Tolerance; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Mol | 1993 |
[Comparison of the effects of molsidomine retard and isosorbide dinitrate retard in patients with stable angina pectoris using an ergometry test].
Topics: Adult; Angina Pectoris; Delayed-Action Preparations; Electrocardiography; Exercise Test; Heart Rate; | 1993 |
[New drug forms of molsidomine, Corvaton-forte and Corvaton-retard, and their antianginal efficacy in stenocardia patients].
Topics: Angina Pectoris; Chronic Disease; Delayed-Action Preparations; Drug Evaluation; Exercise Test; Femal | 1996 |
Clinical pharmacokinetics of molsidomine.
Topics: Absorption; Administration, Oral; Age Factors; Angina Pectoris; Coronary Disease; Humans; Injections | 1996 |
[Influence of combination therapy (isosorbide dinitrate and molsidomine) on the incidence of angina pectoris in patients with coronary heart disease].
Topics: Aged; Angina Pectoris; Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, Dr | 1997 |
Relations of platelet Ca2+ handling and membrane microviscosity to vascular tone and restenosis after angioplasty in human coronary artery.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Platelets; Ca | 1998 |
[Therapy recommendations for adverse effects of Viagra and nitrates (NO-donors)].
Topics: Angina Pectoris; Blood Pressure; Contraindications; Drug Therapy, Combination; Erectile Dysfunction; | 1998 |
[Development of nitrate tolerance].
Topics: Angina Pectoris; Animals; Drug Tolerance; Humans; Molsidomine; Nitrates; Vasodilator Agents | 2000 |
Influence of SIN-1 on platelet Ca2+ handling in patients with suspected coronary artery disease: ex vivo and in vitro studies.
Topics: Angina Pectoris; Aspirin; Biological Transport; Blood Platelets; Calcium; Calcium Signaling; Catalas | 2000 |
[Anti-ischemia drug therapy].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Agents; Fibri | 1991 |
[The effect of molsidomine on the conjunctival microcirculation in patients with ischemic heart disease].
Topics: Adult; Aged; Angina Pectoris; Conjunctiva; Coronary Disease; Drug Evaluation; Female; Humans; Male; | 1989 |
[The effectiveness of digoxin and sidnofarm in the initial stages of chronic circulatory failure].
Topics: Angina Pectoris; Chronic Disease; Digoxin; Drug Evaluation; Female; Heart Failure; Hemodynamics; Hum | 1989 |
[Various aspects of drug therapy of chronic forms of ischemic heart disease].
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Angina Pectoris; Calcium Channel Block | 1985 |
The pharmacologic management of coronary artery disease in 1986.
Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Calcium Channel Blockers; Coronary Disease | 1986 |
[Unstable angina: recent findings and therapeutic applications].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Anticoagulants; Arteriosclerosis; Ca | 1987 |
[Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat].
Topics: Administration, Oral; Angina Pectoris; Animals; Coronary Vasospasm; Electrocardiography; Hypoxia; Is | 1986 |
[Comparative course of maintenance of the effects of nitrite derivatives and molsidomine after prolonged administration].
Topics: Administration, Sublingual; Angina Pectoris; Cardiac Output, Low; Dose-Response Relationship, Drug; | 1988 |
[Problems in long-term therapy of coronary heart disease: pharmacotherapy].
Topics: Angina Pectoris; Coronary Disease; Humans; Long-Term Care; Molsidomine | 1987 |
[Effectiveness of combined administration of obsidan and sidnofarm in patients with ischemic heart disease at a polyclinic].
Topics: Adult; Aged; Ambulatory Care; Angina Pectoris; Drug Therapy, Combination; Female; Humans; Male; Midd | 1988 |
Mechanism of action of antianginal drugs: what is it?
Topics: Angina Pectoris; Coronary Vessels; Humans; Injections, Intra-Arterial; Molsidomine | 1987 |
[Use of corvaton in patients with angina pectoris].
Topics: Adult; Angina Pectoris; Humans; Middle Aged; Molsidomine; Vasodilator Agents | 1987 |
[Long-term use of the peripheral vasodilator corvaton in the polyclinic stage of rehabilitation of patients with myocardial infarction and subclinical manifestations of circulatory insufficiency (clinico-hemodynamic study)].
Topics: Adult; Aged; Angina Pectoris; Hemodynamics; Humans; Middle Aged; Molsidomine; Myocardial Contraction | 1987 |
[The importance of Lopion (molsidomine) in the therapy of myocardial ischemia and angina pectoris].
Topics: Angina Pectoris; Coronary Disease; Exercise Test; Humans; Middle Aged; Molsidomine | 1987 |
[Biorhythm influence on the course of ischemic heart disease during combined treatment with molsidomine and anaprilin].
Topics: Angina Pectoris; Coronary Disease; Drug Therapy, Combination; Emergencies; Humans; Molsidomine; Peri | 1986 |
Hemodynamic and coronary effects of molsidomine at basal state, during atrial pacing, and during cold pressor test in patients with stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Cardiac Pacing, Artificial; Cold Temperature; Coronary | 1985 |
[Molsidomin in stable stress angina].
Topics: Angina Pectoris; Exercise Test; Humans; Molsidomine; Oxadiazoles; Propranolol; Sydnones | 1985 |
[Effectiveness of treating stenocardia patients with obzidan, corvaton and corinfar based on the indices of spirometric bicycle ergometry and of central hemodynamics].
Topics: Adult; Angina Pectoris; Drug Evaluation; Exercise Test; Hemodynamics; Humans; Male; Middle Aged; Mol | 1985 |
Haemodynamic effects of molsidomine in patients with severe chronic coronary disease.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Coronary Circulation; Coronary Disease; Electric Stimu | 1985 |
[Other drugs used in angina pectoris].
Topics: Amiodarone; Angina Pectoris; Humans; Molsidomine; Perhexiline; Prenylamine; Sydnones; Vasodilator Ag | 1985 |