molsidomine has been researched along with Aging in 8 studies
Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nitroglycerin pre-exposure (10 microM for 30 min) provoked a significant shift to the right of the dose-response curve to nitroglycerin in aortae isolated from rats of 8 weeks, 12 and 18 months." | 1.29 | Nitrate tolerance and aging in isolated rat aorta. ( Berkenboom, G; Brékine, D; Fontaine, J; Unger, P, 1993) |
| " After a 2 mg oral administration, molsidomine elimination half-life was prolonged in elderly subjects (1." | 1.28 | Pharmacokinetics of molsidomine and of its active metabolite, SIN-1 (or linsidomine), in the elderly. ( Advenier, C; Cordonnier, P; Ducreuzet, C; Forestier, A; Pays, M; Spreux-Varoquaux, O; Ulmer, B, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Selvaratnam, JS | 1 |
| Robaire, B | 1 |
| Satoh, M | 1 |
| Kidokoro, K | 1 |
| Ozeki, M | 1 |
| Nagasu, H | 1 |
| Nishi, Y | 1 |
| Ihoriya, C | 1 |
| Fujimoto, S | 1 |
| Sasaki, T | 1 |
| Kashihara, N | 1 |
| Carlo, MD | 1 |
| Loeser, RF | 1 |
| Pitsikas, N | 1 |
| Rigamonti, AE | 1 |
| Cella, SG | 1 |
| Sakellaridis, N | 1 |
| Muller, EE | 1 |
| Unger, P | 1 |
| Berkenboom, G | 1 |
| Brékine, D | 1 |
| Fontaine, J | 1 |
| Tschudi, MR | 1 |
| Criscione, L | 1 |
| Lüscher, TF | 1 |
| Spreux-Varoquaux, O | 1 |
| Ulmer, B | 1 |
| Cordonnier, P | 1 |
| Forestier, A | 1 |
| Pays, M | 1 |
| Ducreuzet, C | 1 |
| Advenier, C | 1 |
| Fuchs, J | 1 |
| Freisleben, HJ | 1 |
| Mainka, L | 1 |
| Zimmer, G | 1 |
8 other studies available for molsidomine and Aging
| Article | Year |
|---|---|
Effects of Aging and Oxidative Stress on Spermatozoa of Superoxide-Dismutase 1- and Catalase-Null Mice.
Topics: Aging; Animals; Catalase; Fertility; Male; Mice; Mice, Knockout; Molsidomine; Oxidative Stress; Reac | 2016 |
Angiostatin production increases in response to decreased nitric oxide in aging rat kidney.
Topics: Aging; Angiostatins; Animals; Blotting, Western; Cathepsin D; Human Umbilical Vein Endothelial Cells | 2013 |
Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels.
Topics: Adolescent; Adult; Aging; Cartilage, Articular; Cell Death; Cell Survival; Chondrocytes; Glutathione | 2003 |
The nitric oxide donor molsidomine antagonizes age-related memory deficits in the rat.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Dose-Respon | 2005 |
Nitrate tolerance and aging in isolated rat aorta.
Topics: Aging; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniqu | 1993 |
Effect of aging and hypertension on endothelial function of rat coronary arteries.
Topics: Acetylcholine; Aging; Animals; Coronary Vessels; Endothelium, Vascular; In Vitro Techniques; Male; M | 1991 |
Pharmacokinetics of molsidomine and of its active metabolite, SIN-1 (or linsidomine), in the elderly.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; F | 1991 |
Mitochondrial sulfhydryl groups under oligomycin-inhibited, aging, and uncoupling conditions: beneficial influence of cardioprotective drugs.
Topics: Aging; Animals; In Vitro Techniques; Isosorbide Dinitrate; Mitochondria, Heart; Molsidomine; Oligomy | 1988 |