molnupiravir and Hemorrhagic-Fever--Ebola

molnupiravir has been researched along with Hemorrhagic-Fever--Ebola* in 2 studies

Other Studies

2 other study(ies) available for molnupiravir and Hemorrhagic-Fever--Ebola

ArticleYear
The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N
    Antiviral research, 2023, Volume: 209

    Topics: Animals; Antiviral Agents; Ebolavirus; Hemorrhagic Fever, Ebola; Mice; Ribonucleosides

2023
Instruction of molecular structure similarity and scaffolds of drugs under investigation in ebola virus treatment by atom-pair and graph network: A combination of favipiravir and molnupiravir.
    Computational biology and chemistry, 2022, Volume: 101

    The virus that causes Ebola is fatal. Although many researchers have attempted to contain this deadly infection, the fatality rate remains high. The atom-pair fingerprint technique was used to compare drugs suggested for the treatment of Ebola or those that are currently being tested in clinical settings. Subsequently, using scaffold network graph (SNG) methods, the molecular and structural scaffolds of the drugs chosen based on these similar results were created, and the drug structures were examined. Public databases (PubChem and DrugBank) and literature regarding Ebola treatment were used in the analysis. Graphical representations of the molecular architecture and core structures of the drugs with the highest similarity to Food and Drug Administration (FDA)-approved drugs were produced using the SNG method. The combination of molnupiravir, the first licensed oral medication candidate for COVID-19, and favipiravir, employed in other viral outbreaks, should be further researched for treating Ebola, as observed in our study. We also believe that chemists will benefit from understanding the core structure(s) of medication molecules effective against the Ebola virus, their inhibitors, and the chemical structure similarities of existing pharmaceuticals utilized to build alternative drugs or drug combinations.

    Topics: Antiviral Agents; COVID-19; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Molecular Structure; Pharmaceutical Preparations; United States

2022