mofegiline and Pneumonia

mofegiline has been researched along with Pneumonia* in 1 studies

Other Studies

1 other study(ies) available for mofegiline and Pneumonia

Article	Year
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1). Bioorganic & medicinal chemistry letters, 2012, Jun-15, Volume: 22, Issue:12 A new class of 3-fluoroallyl amine-based SSAO/VAP-1 inhibitors is reported. These compounds have excellent selectivity over diamine oxidase, MAO-A and MAO-B. Synthesis and SAR studies leading to compound 28 (PXS-4159A) are reported. The pharmacokinetic profile of 28 in the rat, together with activity in a murine model of lung inflammation are also disclosed. Topics: Allyl Compounds; Amine Oxidase (Copper-Containing); Amines; Animals; Anti-Inflammatory Agents; Drug Discovery; Halogenation; Humans; Isoenzymes; Mice; Models, Molecular; Monoamine Oxidase Inhibitors; Pneumonia; Rats; Structure-Activity Relationship	2012

Article

Year

The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1).

Bioorganic & medicinal chemistry letters, 2012, Jun-15, Volume: 22, Issue:12

A new class of 3-fluoroallyl amine-based SSAO/VAP-1 inhibitors is reported. These compounds have excellent selectivity over diamine oxidase, MAO-A and MAO-B. Synthesis and SAR studies leading to compound 28 (PXS-4159A) are reported. The pharmacokinetic profile of 28 in the rat, together with activity in a murine model of lung inflammation are also disclosed.

Topics: Allyl Compounds; Amine Oxidase (Copper-Containing); Amines; Animals; Anti-Inflammatory Agents; Drug Discovery; Halogenation; Humans; Isoenzymes; Mice; Models, Molecular; Monoamine Oxidase Inhibitors; Pneumonia; Rats; Structure-Activity Relationship

2012