mofarotene and Colonic-Neoplasms

mofarotene has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for mofarotene and Colonic-Neoplasms

Article	Year
The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro. Cancer letters, 1994, Sep-30, Volume: 85, Issue:1 We have examined the antiproliferative effects of the arotinoid Ro 40-8757 in 3 drug-resistant human adenocarcinoma cell lines: the colonic cells HT29-5FU and CaCo2, and the mammary cells MCF-7mdr1. Whereas all-trans retinoic acid had no effect at the concentration of 10(-6) M, Ro 40-8757 was found to exert a high antiproliferative action with similar inhibitory potency (IC50) in drug-resistant and parental cell lines (range, 0.06 x 10(-6) to 0.57 x 10(-6) M). We conclude that: (1) thymidylate synthase is not involved in the mechanism of action of Ro 40-8757; (2) the mdr1 gene product does not recognize this retinoic derivative, and (3) Ro 40-8757, alone or in combinations with other cytotoxic drugs, can be very useful in patients with progressive disease after conventional chemotherapy. Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; Doxorubicin; Drug Resistance, Multiple; Fluorouracil; Humans; Morpholines; Retinoids; Tumor Cells, Cultured	1994

Article

Year

The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro.

Cancer letters, 1994, Sep-30, Volume: 85, Issue:1

We have examined the antiproliferative effects of the arotinoid Ro 40-8757 in 3 drug-resistant human adenocarcinoma cell lines: the colonic cells HT29-5FU and CaCo2, and the mammary cells MCF-7mdr1. Whereas all-trans retinoic acid had no effect at the concentration of 10(-6) M, Ro 40-8757 was found to exert a high antiproliferative action with similar inhibitory potency (IC50) in drug-resistant and parental cell lines (range, 0.06 x 10(-6) to 0.57 x 10(-6) M). We conclude that: (1) thymidylate synthase is not involved in the mechanism of action of Ro 40-8757; (2) the mdr1 gene product does not recognize this retinoic derivative, and (3) Ro 40-8757, alone or in combinations with other cytotoxic drugs, can be very useful in patients with progressive disease after conventional chemotherapy.

Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; Doxorubicin; Drug Resistance, Multiple; Fluorouracil; Humans; Morpholines; Retinoids; Tumor Cells, Cultured

1994