moducrin and Hypertension

Topics: Adolescent; Amiloride; Antihypertensive Agents; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Propranolol; Spironolactone; Timolol

An open, multi-centre study was carried out in general practice to compare the efficacy and tolerance of antihypertensive therapy with once-daily and twice-daily dosage of a fixed ratio combination of hydrochlorothiazide (25 mg), amiloride (2.5 mg) and timolol (10 mg). A total of 604 patients with mild to moderate hypertension were treated over a period of 12 weeks with either 1 to 2 tablets once-daily (294 patients) or 1/2 to 1 tablet twice-daily (310 patients). The results showed that there was a significant reduction in systolic and diastolic blood pressures in both groups after only 2-weeks' therapy and the overall reduction after 12 weeks was 31/19 mmHg, with 57% of patients being adequately controlled on the equivalent of 1 tablet per day, whether taken once daily or in divided doses. Forty-six (8%) patients withdrew from the study because of drug-related symptoms, mainly central nervous system in origin. Overall, treatment with either regimen was considered suitable and acceptable by over 80% of patients and doctors.

Topics: Adult; Aged; Amiloride; Blood Pressure; Drug Administration Schedule; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Time Factors; Timolol

An open study was carried out in general practice to assess the efficacy and tolerance of a fixed ratio combination of hydrochlorothiazide (25 mg), amiloride (2.5 mg) and timolol (10 mg) in the treatment of patients with mild to moderate hypertension, and to determine if there were any differences in response when medication was taken before or after food. A total of 663 patients was studied and received 1 to 2 tablets once daily for a period of 12 weeks; 322 patients took their medication before and 341 after food. The results showed that there were similar significant reductions in systolic and diastolic blood pressure and in heart rate in both groups, over half of the patients being controlled (less than 90 mmHg diastolic) after 2 weeks and 80% by the end of the study period. Relatively few adverse effects were reported and the incidence during treatment was less than that recorded on entry to the study. There was no evidence to suggest that the timing of drug intake in relation to food had any effect on the efficacy or tolerance of the combination.

Topics: Adult; Aged; Amiloride; Drug Combinations; Female; Food; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Timolol

An open study was carried out in general practice to assess the efficacy and tolerance of a timolol (10 mg)/hydrochlorothiazide (25 mg)/amiloride (2.5 mg) preparation in 558 hypertensive patients previously receiving multi-dose antihypertensive therapy, and to determine whether the results were influenced by the manner in which the doctor conducted this change in therapy. Patients received 1 or, if necessary, 2 tablets once daily over a period of 12 weeks and were randomly allocated on entry to one of two groups. One group was given a full explanation for the change in therapy, the other group was simply told that treatment was to be changed. The results showed that the change in treatment led to a significant reduction in blood pressure in both groups, at a dosage of 1 tablet daily in over half the patients, and the majority (88%) preferred the new form of treatment. Patient acceptance was good and the number of reports of adverse symptoms decreased during the study period. There was no significant difference in any of the results between the two groups.

Topics: Adult; Aged; Amiloride; Blood Pressure; Drug Combinations; Family Practice; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Patient Compliance; Propanolamines; Pyrazines; Timolol

Topics: Adult; Aged; Amiloride; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Outcome and Process Assessment, Health Care; Patient Compliance; Physician-Patient Relations; Timolol

Topics: Amiloride; Diagnosis, Differential; Drug Combinations; Drug Interactions; Female; Humans; Hydrochlorothiazide; Hypertension; Hyponatremia; Middle Aged; Subarachnoid Hemorrhage; Timolol

Topics: Adult; Age Factors; Aged; Amiloride; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Timolol

Topics: Amiloride; Antihypertensive Agents; Blood Pressure; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Lipids; Male; Middle Aged; Potassium; Propanolamines; Pyrazines; Timolol

Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Body Weight; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Propanolamines; Pyrazines; Random Allocation; Timolol