Page last updated: 2024-10-31

modafinil and Substance-Related Disorders

modafinil has been researched along with Substance-Related Disorders in 41 studies

Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.

Substance-Related Disorders: Disorders related to substance use or abuse.

Research Excerpts

ExcerptRelevanceReference
"The benefit (Epworth sleepiness score, ESS; visual analog scale, patient and clinician opinions) and risks (habituation, adverse effects) of modafinil were studied in a consecutive clinical cohort of 104 IH patients (59 with long sleep time) and 126 patients with narcolepsy/cataplexy."7.77Benefit and risk of modafinil in idiopathic hypersomnia vs. narcolepsy with cataplexy. ( Arnulf, I; Dauvilliers, Y; Drouot, X; Franco, P; Golmard, JL; Lavault, S; Lecendreux, M; Leu-Semenescu, S, 2011)
"The benefit (Epworth sleepiness score, ESS; visual analog scale, patient and clinician opinions) and risks (habituation, adverse effects) of modafinil were studied in a consecutive clinical cohort of 104 IH patients (59 with long sleep time) and 126 patients with narcolepsy/cataplexy."3.77Benefit and risk of modafinil in idiopathic hypersomnia vs. narcolepsy with cataplexy. ( Arnulf, I; Dauvilliers, Y; Drouot, X; Franco, P; Golmard, JL; Lavault, S; Lecendreux, M; Leu-Semenescu, S, 2011)
"Modafinil is a unique wake-promoting agent."2.69An evaluation of the abuse potential of modafinil using methylphenidate as a reference. ( Jasinski, DR, 2000)
"Modafinil (CRL 40476) is a vigilance-promoting, putative central alpha 1-adrenergic agonist with a pharmacological profile quite different from that of amphetamine."2.67Treatment of the alcoholic organic brain syndrome: double-blind, placebo-controlled clinical, psychometric and electroencephalographic mapping studies with modafinil. ( Anderer, P; Frey, R; Grünberger, J; Mader, R; Saletu, B; Saletu, M, 1993)
"Modafinil- and placebo-treated patients improved continously over the 6-week period."2.67On the treatment of the alcoholic organic brain syndrome with an alpha-adrenergic agonist modafinil: double-blind, placebo-controlled clinical, psychometric and neurophysiological studies. ( Frey, R; Grünberger, J; Mader, R; Saletu, B; Saletu, M; Zatschek, I, 1990)
" Side effects of stimulants are generally mild, short lived, and responsive to adjustments in dosage or timing."2.44Changes and challenges: managing ADHD in a fast-paced world. ( Bukstein, OG; Crismon, ML; Manos, MJ; Tom-Revzon, C, 2007)
"Respondents who had reported a psychiatric diagnosis declared higher subjective benefits of modafinil."1.56The off-prescription use of modafinil: An online survey of perceived risks and benefits. ( Rycroft, N; Smith-Spark, JH; Teodorini, RD, 2020)
"Modafinil is used because of its wakefulness-promoting properties for treatment of diseases associated with extreme sleepiness (i."1.48Modafinil in Forensic and Clinical Toxicology-Case Reports, Analytics and Literature. ( Andresen-Streichert, H; Radünz, L; Reuter, H, 2018)
"Modafinil was associated with DAAD in the total dataset (ROR, 2."1.46Sensitivity of Quantitative Signal Detection in Regards to Pharmacological Neuroenhancement. ( Connemann, BJ; Gahr, M; Schönfeldt-Lecuona, C; Zeiss, R, 2017)
"R-modafinil displays an in vitro profile different from cocaine."1.38R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. ( Cao, J; Katz, JL; Kopajtic, T; Loland, CJ; Mazier, S; Mereu, M; Newman, AH; Okunola, OM; Prisinzano, TE; Shi, L; Tanda, G, 2012)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (7.32)18.2507
2000's14 (34.15)29.6817
2010's21 (51.22)24.3611
2020's3 (7.32)2.80

Authors

AuthorsStudies
Reinert, JP1
Dunn, RL1
de Oliveira Cata Preta, B1
Miranda, VIA1
Bertoldi, AD1
Teodorini, RD1
Rycroft, N1
Smith-Spark, JH1
Tardelli, VS1
Bisaga, A1
Arcadepani, FB1
Gerra, G1
Levin, FR1
Fidalgo, TM1
Iglseder, B1
Radünz, L1
Reuter, H1
Andresen-Streichert, H1
Mereu, M2
Bonci, A1
Newman, AH2
Tanda, G2
McElhiney, M1
Rabkin, J1
Van Gorp, W1
Rabkin, R2
Dhillon, R1
Wu, X1
Bastiampillai, T1
Tibrewal, P1
Ram, SS1
Hussainy, S1
Henning, M1
Jensen, M1
Russell, B1
Jerry, JM1
Shirvani, N1
Dale, R1
Bisagno, V1
González, B1
Urbano, FJ1
Dance, A1
Gahr, M1
Connemann, BJ1
Schönfeldt-Lecuona, C1
Zeiss, R1
McElhiney, MC1
Rabkin, JG1
Nunes, EV1
Volkow, ND1
Fowler, JS1
Logan, J1
Alexoff, D1
Zhu, W1
Telang, F1
Wang, GJ1
Jayne, M1
Hooker, JM1
Wong, C1
Hubbard, B1
Carter, P1
Warner, D1
King, P1
Shea, C1
Xu, Y1
Muench, L1
Apelskog-Torres, K1
Tahsili-Fahadan, P1
Malcolm, R2
Aston-Jones, G1
Herin, DV1
Rush, CR3
Grabowski, J1
Paterson, NE1
Fedolak, A1
Olivier, B1
Hanania, T1
Ghavami, A1
Caldarone, B1
Franke, AG1
Lieb, K1
Brady, KT1
Gray, KM1
Tolliver, BK1
Lavault, S1
Dauvilliers, Y1
Drouot, X1
Leu-Semenescu, S1
Golmard, JL1
Lecendreux, M1
Franco, P1
Arnulf, I1
Wuo-Silva, R1
Fukushiro, DF1
Borçoi, AR1
Fernandes, HA1
Procópio-Souza, R1
Hollais, AW1
Santos, R1
Ribeiro, LT1
Corrêa, JM1
Talhati, F1
Saito, LP1
Aramini, TC1
Kameda, SR1
Bittencourt, LR1
Tufik, S1
Frussa-Filho, R1
Camenzind, M1
Loland, CJ1
Okunola, OM1
Cao, J1
Prisinzano, TE1
Mazier, S1
Kopajtic, T1
Shi, L1
Katz, JL1
Estrada, A1
Kelley, AM1
Webb, CM1
Athy, JR1
Crowley, JS1
Book, SW1
Moak, D1
DeVane, L1
Czepowicz, V1
Berigan, T1
Stoops, WW1
Lile, JA1
Fillmore, MT1
Glaser, PE1
Kruszewski, SP2
O'Brien, CP1
Dackis, CA1
Kampman, K1
Ling, W2
Rawson, R1
Shoptaw, S1
Kuehn, BM1
Klotz, SG1
Manos, MJ1
Tom-Revzon, C1
Bukstein, OG1
Crismon, ML1
Shearer, J1
Saletu, B2
Saletu, M2
Grünberger, J2
Frey, R2
Anderer, P1
Mader, R2
Akerstedt, T1
Ficca, G1
Jasinski, DR1
Kelly, TH1
Hays, LR1
Baker, RW1
Wooten, AF1
Zatschek, I1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neurochemical Modulation Cognitive Performance and Subjective Wellbeing In Healthy Controls[NCT02051153]64 participants (Actual)Interventional2009-10-31Completed
A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102]Phase 4105 participants (Actual)Interventional2016-02-29Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit

Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours

Interventionminutes (Mean)
Placebo53.5
Modafinil61.0

Postanesthesia Quality Recovery Scale Score

Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery

Interventionunits on a scale (Mean)
Placebo-5.67
Modafinil-8.91

Reviews

12 reviews available for modafinil and Substance-Related Disorders

ArticleYear
Management of overdoses of loperamide, gabapentin, and modafinil: a literature review.
    Expert review of clinical pharmacology, 2019, Volume: 12, Issue:9

    Topics: Drug Overdose; Emergency Treatment; Gabapentin; Humans; Loperamide; Modafinil; Substance-Related Dis

2019
Management of overdoses of loperamide, gabapentin, and modafinil: a literature review.
    Expert review of clinical pharmacology, 2019, Volume: 12, Issue:9

    Topics: Drug Overdose; Emergency Treatment; Gabapentin; Humans; Loperamide; Modafinil; Substance-Related Dis

2019
Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis.
    Psychopharmacology, 2020, Volume: 237, Issue:8

    Topics: Amphetamine; Central Nervous System Stimulants; Cocaine; Double-Blind Method; Humans; Lisdexamfetami

2020
Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis.
    Psychopharmacology, 2020, Volume: 237, Issue:8

    Topics: Amphetamine; Central Nervous System Stimulants; Cocaine; Double-Blind Method; Humans; Lisdexamfetami

2020
[Doping for the brain].
    Zeitschrift fur Gerontologie und Geriatrie, 2018, Volume: 51, Issue:2

    Topics: Aged; Amphetamines; Brain; Cognitive Aging; Dietary Supplements; Humans; Illicit Drugs; Methylphenid

2018
[Doping for the brain].
    Zeitschrift fur Gerontologie und Geriatrie, 2018, Volume: 51, Issue:2

    Topics: Aged; Amphetamines; Brain; Cognitive Aging; Dietary Supplements; Humans; Illicit Drugs; Methylphenid

2018
The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders.
    Psychopharmacology, 2013, Volume: 229, Issue:3

    Topics: Benzhydryl Compounds; Brain; Cognition; Dopamine; Dopamine Plasma Membrane Transport Proteins; Human

2013
The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders.
    Psychopharmacology, 2013, Volume: 229, Issue:3

    Topics: Benzhydryl Compounds; Brain; Cognition; Dopamine; Dopamine Plasma Membrane Transport Proteins; Human

2013
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits.
    Pharmacological research, 2016, Volume: 109

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Dopamine; Humans; Methamp

2016
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits.
    Pharmacological research, 2016, Volume: 109

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Dopamine; Humans; Methamp

2016
Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies.
    Annals of the New York Academy of Sciences, 2010, Volume: 1187

    Topics: Animals; Behavior Therapy; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Clini

2010
Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies.
    Annals of the New York Academy of Sciences, 2010, Volume: 1187

    Topics: Animals; Behavior Therapy; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Clini

2010
[Pharmacological neuroenhancement and brain doping : Chances and risks].
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 2010, Volume: 53, Issue:8

    Topics: Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cross-Sectional Studies; Dose-Respon

2010
[Pharmacological neuroenhancement and brain doping : Chances and risks].
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 2010, Volume: 53, Issue:8

    Topics: Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cross-Sectional Studies; Dose-Respon

2010
Cognitive enhancers in the treatment of substance use disorders: clinical evidence.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:2

    Topics: Adrenergic Agents; Benzhydryl Compounds; Central Nervous System Stimulants; Cholinesterase Inhibitor

2011
Cognitive enhancers in the treatment of substance use disorders: clinical evidence.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:2

    Topics: Adrenergic Agents; Benzhydryl Compounds; Central Nervous System Stimulants; Cholinesterase Inhibitor

2011
Management of methamphetamine abuse and dependence.
    Current psychiatry reports, 2006, Volume: 8, Issue:5

    Topics: Baclofen; Benzhydryl Compounds; Brain; Bupropion; Cognition Disorders; Cognitive Behavioral Therapy;

2006
Management of methamphetamine abuse and dependence.
    Current psychiatry reports, 2006, Volume: 8, Issue:5

    Topics: Baclofen; Benzhydryl Compounds; Brain; Bupropion; Cognition Disorders; Cognitive Behavioral Therapy;

2006
Changes and challenges: managing ADHD in a fast-paced world.
    Journal of managed care pharmacy : JMCP, 2007, Volume: 13, Issue:9 Suppl B

    Topics: Algorithms; Antihypertensive Agents; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hype

2007
Changes and challenges: managing ADHD in a fast-paced world.
    Journal of managed care pharmacy : JMCP, 2007, Volume: 13, Issue:9 Suppl B

    Topics: Algorithms; Antihypertensive Agents; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hype

2007
The principles of agonist pharmacotherapy for psychostimulant dependence.
    Drug and alcohol review, 2008, Volume: 27, Issue:3

    Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Dopamine Agonists; Heroin Dependence; Human

2008
The principles of agonist pharmacotherapy for psychostimulant dependence.
    Drug and alcohol review, 2008, Volume: 27, Issue:3

    Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Dopamine Agonists; Heroin Dependence; Human

2008
Alertness-enhancing drugs as a countermeasure to fatigue in irregular work hours.
    Chronobiology international, 1997, Volume: 14, Issue:2

    Topics: Amphetamine; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Fatigue; Humans; Mod

1997
Alertness-enhancing drugs as a countermeasure to fatigue in irregular work hours.
    Chronobiology international, 1997, Volume: 14, Issue:2

    Topics: Amphetamine; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Fatigue; Humans; Mod

1997

Trials

6 trials available for modafinil and Substance-Related Disorders

ArticleYear
Effect of armodafinil on cognition in patients with HIV/AIDS and fatigue.
    Journal of clinical and experimental neuropsychology, 2013, Volume: 35, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Benzhydryl Compounds; CD4 Lymphocyte Count; Central

2013
Effect of armodafinil on cognition in patients with HIV/AIDS and fatigue.
    Journal of clinical and experimental neuropsychology, 2013, Volume: 35, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Benzhydryl Compounds; CD4 Lymphocyte Count; Central

2013
Modafinil as a replacement for dextroamphetamine for sustaining alertness in military helicopter pilots.
    Aviation, space, and environmental medicine, 2012, Volume: 83, Issue:6

    Topics: Adult; Aerospace Medicine; Aircraft; Arousal; Benzhydryl Compounds; Central Nervous System Stimulant

2012
Modafinil as a replacement for dextroamphetamine for sustaining alertness in military helicopter pilots.
    Aviation, space, and environmental medicine, 2012, Volume: 83, Issue:6

    Topics: Adult; Aerospace Medicine; Aircraft; Arousal; Benzhydryl Compounds; Central Nervous System Stimulant

2012
Treatment of the alcoholic organic brain syndrome: double-blind, placebo-controlled clinical, psychometric and electroencephalographic mapping studies with modafinil.
    Neuropsychobiology, 1993, Volume: 27, Issue:1

    Topics: Adult; Alcoholism; Analysis of Variance; Benzhydryl Compounds; Brain; Brain Mapping; Central Nervous

1993
Treatment of the alcoholic organic brain syndrome: double-blind, placebo-controlled clinical, psychometric and electroencephalographic mapping studies with modafinil.
    Neuropsychobiology, 1993, Volume: 27, Issue:1

    Topics: Adult; Alcoholism; Analysis of Variance; Benzhydryl Compounds; Brain; Brain Mapping; Central Nervous

1993
An evaluation of the abuse potential of modafinil using methylphenidate as a reference.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:1

    Topics: Adult; Appetite; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Cross-Over Studie

2000
An evaluation of the abuse potential of modafinil using methylphenidate as a reference.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:1

    Topics: Adult; Appetite; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Cross-Over Studie

2000
Acute behavioral and physiological effects of modafinil in drug abusers.
    Behavioural pharmacology, 2002, Volume: 13, Issue:2

    Topics: Adult; Behavior; Benzhydryl Compounds; Blood Pressure; Central Nervous System Stimulants; Cocaine-Re

2002
Acute behavioral and physiological effects of modafinil in drug abusers.
    Behavioural pharmacology, 2002, Volume: 13, Issue:2

    Topics: Adult; Behavior; Benzhydryl Compounds; Blood Pressure; Central Nervous System Stimulants; Cocaine-Re

2002
On the treatment of the alcoholic organic brain syndrome with an alpha-adrenergic agonist modafinil: double-blind, placebo-controlled clinical, psychometric and neurophysiological studies.
    Progress in neuro-psychopharmacology & biological psychiatry, 1990, Volume: 14, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Alcoholism; Attention; Benzhydryl Compounds; Blood Pressure; Centr

1990
On the treatment of the alcoholic organic brain syndrome with an alpha-adrenergic agonist modafinil: double-blind, placebo-controlled clinical, psychometric and neurophysiological studies.
    Progress in neuro-psychopharmacology & biological psychiatry, 1990, Volume: 14, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Alcoholism; Attention; Benzhydryl Compounds; Blood Pressure; Centr

1990

Other Studies

23 other studies available for modafinil and Substance-Related Disorders

ArticleYear
Psychostimulant Use for Neuroenhancement (Smart Drugs) among College Students in Brazil.
    Substance use & misuse, 2020, Volume: 55, Issue:4

    Topics: Brazil; Central Nervous System Stimulants; Cognition; Cross-Sectional Studies; Humans; Methylphenida

2020
Psychostimulant Use for Neuroenhancement (Smart Drugs) among College Students in Brazil.
    Substance use & misuse, 2020, Volume: 55, Issue:4

    Topics: Brazil; Central Nervous System Stimulants; Cognition; Cross-Sectional Studies; Humans; Methylphenida

2020
The off-prescription use of modafinil: An online survey of perceived risks and benefits.
    PloS one, 2020, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Humans; Internet; Male; Mental Di

2020
The off-prescription use of modafinil: An online survey of perceived risks and benefits.
    PloS one, 2020, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Humans; Internet; Male; Mental Di

2020
Modafinil in Forensic and Clinical Toxicology-Case Reports, Analytics and Literature.
    Journal of analytical toxicology, 2018, Jun-01, Volume: 42, Issue:5

    Topics: Accidents, Traffic; Adult; Analytic Sample Preparation Methods; Benzhydryl Compounds; Cadaver; Calib

2018
Modafinil in Forensic and Clinical Toxicology-Case Reports, Analytics and Literature.
    Journal of analytical toxicology, 2018, Jun-01, Volume: 42, Issue:5

    Topics: Accidents, Traffic; Adult; Analytic Sample Preparation Methods; Benzhydryl Compounds; Cadaver; Calib

2018
Could modafinil be a drug of dependence?
    The Australian and New Zealand journal of psychiatry, 2015, Volume: 49, Issue:5

    Topics: Amphetamine-Related Disorders; Benzhydryl Compounds; Disorders of Excessive Somnolence; Humans; Male

2015
Could modafinil be a drug of dependence?
    The Australian and New Zealand journal of psychiatry, 2015, Volume: 49, Issue:5

    Topics: Amphetamine-Related Disorders; Benzhydryl Compounds; Disorders of Excessive Somnolence; Humans; Male

2015
Prevalence of cognitive enhancer use among New Zealand tertiary students.
    Drug and alcohol review, 2016, Volume: 35, Issue:3

    Topics: Adult; Amphetamines; Benzhydryl Compounds; Female; Humans; Male; Methylphenidate; Modafinil; Motivat

2016
Prevalence of cognitive enhancer use among New Zealand tertiary students.
    Drug and alcohol review, 2016, Volume: 35, Issue:3

    Topics: Adult; Amphetamines; Benzhydryl Compounds; Female; Humans; Male; Methylphenidate; Modafinil; Motivat

2016
Addiction to Armodafinil and Modafinil Presenting With Paranoia.
    Journal of clinical psychopharmacology, 2016, Volume: 36, Issue:1

    Topics: Benzhydryl Compounds; Humans; Male; Middle Aged; Modafinil; Paranoid Disorders; Substance-Related Di

2016
Addiction to Armodafinil and Modafinil Presenting With Paranoia.
    Journal of clinical psychopharmacology, 2016, Volume: 36, Issue:1

    Topics: Benzhydryl Compounds; Humans; Male; Middle Aged; Modafinil; Paranoid Disorders; Substance-Related Di

2016
Smart drugs: A dose of intelligence.
    Nature, 2016, Mar-03, Volume: 531, Issue:7592

    Topics: Aging; Amphetamines; Animals; Benzhydryl Compounds; Biomedical Enhancement; Caffeine; Child; Cogniti

2016
Smart drugs: A dose of intelligence.
    Nature, 2016, Mar-03, Volume: 531, Issue:7592

    Topics: Aging; Amphetamines; Animals; Benzhydryl Compounds; Biomedical Enhancement; Caffeine; Child; Cogniti

2016
Sensitivity of Quantitative Signal Detection in Regards to Pharmacological Neuroenhancement.
    International journal of molecular sciences, 2017, Jan-05, Volume: 18, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Adverse Drug Reaction Reporting Systems; Atomoxetine Hydrochloride; Au

2017
Sensitivity of Quantitative Signal Detection in Regards to Pharmacological Neuroenhancement.
    International journal of molecular sciences, 2017, Jan-05, Volume: 18, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Adverse Drug Reaction Reporting Systems; Atomoxetine Hydrochloride; Au

2017
Provigil (modafinil) plus cognitive behavioral therapy for methamphetamine use in HIV+ gay men: a pilot study.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:1

    Topics: Adult; Behavior Therapy; Benzhydryl Compounds; Combined Modality Therapy; HIV Infections; Homosexual

2009
Provigil (modafinil) plus cognitive behavioral therapy for methamphetamine use in HIV+ gay men: a pilot study.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:1

    Topics: Adult; Behavior Therapy; Benzhydryl Compounds; Combined Modality Therapy; HIV Infections; Homosexual

2009
Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.
    JAMA, 2009, Mar-18, Volume: 301, Issue:11

    Topics: Adult; Benzhydryl Compounds; Brain; Carbon Radioisotopes; Caudate Nucleus; Central Nervous System St

2009
Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.
    JAMA, 2009, Mar-18, Volume: 301, Issue:11

    Topics: Adult; Benzhydryl Compounds; Brain; Carbon Radioisotopes; Caudate Nucleus; Central Nervous System St

2009
Modafinil: an anti-relapse medication.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:1

    Topics: Animals; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Humans; Modafinil; Radionuc

2010
Modafinil: an anti-relapse medication.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:1

    Topics: Animals; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Humans; Modafinil; Radionuc

2010
Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 95, Issue:4

    Topics: Animals; Benzhydryl Compounds; Biogenic Monoamines; Central Nervous System Stimulants; Cocaine; Dopa

2010
Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 95, Issue:4

    Topics: Animals; Benzhydryl Compounds; Biogenic Monoamines; Central Nervous System Stimulants; Cocaine; Dopa

2010
Benefit and risk of modafinil in idiopathic hypersomnia vs. narcolepsy with cataplexy.
    Sleep medicine, 2011, Volume: 12, Issue:6

    Topics: Adult; Benzhydryl Compounds; Cataplexy; Central Nervous System Stimulants; Cohort Studies; Databases

2011
Benefit and risk of modafinil in idiopathic hypersomnia vs. narcolepsy with cataplexy.
    Sleep medicine, 2011, Volume: 12, Issue:6

    Topics: Adult; Benzhydryl Compounds; Cataplexy; Central Nervous System Stimulants; Cohort Studies; Databases

2011
Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study.
    Addiction biology, 2011, Volume: 16, Issue:4

    Topics: Animals; Benzhydryl Compounds; Brain; Central Nervous System Sensitization; Central Nervous System S

2011
Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study.
    Addiction biology, 2011, Volume: 16, Issue:4

    Topics: Animals; Benzhydryl Compounds; Brain; Central Nervous System Sensitization; Central Nervous System S

2011
[Brain doping. With smart pills becoming the perfect human being].
    Krankenpflege. Soins infirmiers, 2012, Volume: 105, Issue:2

    Topics: Achievement; Adolescent; Adult; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Chil

2012
[Brain doping. With smart pills becoming the perfect human being].
    Krankenpflege. Soins infirmiers, 2012, Volume: 105, Issue:2

    Topics: Achievement; Adolescent; Adult; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Chil

2012
R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse.
    Biological psychiatry, 2012, Sep-01, Volume: 72, Issue:5

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Plasma

2012
R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse.
    Biological psychiatry, 2012, Sep-01, Volume: 72, Issue:5

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Plasma

2012
Clinical applications of modafinil in stimulant abusers: low abuse potential.
    The American journal on addictions, 2002,Summer, Volume: 11, Issue:3

    Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Female; Humans; Male; Modafinil; Neu

2002
Clinical applications of modafinil in stimulant abusers: low abuse potential.
    The American journal on addictions, 2002,Summer, Volume: 11, Issue:3

    Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Female; Humans; Male; Modafinil; Neu

2002
Modafinil treatment of excessive sedation associated with divalproex sodium.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2004, Volume: 49, Issue:1

    Topics: Adult; Antimanic Agents; Benzhydryl Compounds; Bipolar Disorder; Central Nervous System Stimulants;

2004
Modafinil treatment of excessive sedation associated with divalproex sodium.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2004, Volume: 49, Issue:1

    Topics: Adult; Antimanic Agents; Benzhydryl Compounds; Bipolar Disorder; Central Nervous System Stimulants;

2004
Reinforcing effects of modafinil: influence of dose and behavioral demands following drug administration.
    Psychopharmacology, 2005, Volume: 182, Issue:1

    Topics: Adult; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Dose-Response Relationship,

2005
Reinforcing effects of modafinil: influence of dose and behavioral demands following drug administration.
    Psychopharmacology, 2005, Volume: 182, Issue:1

    Topics: Adult; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Dose-Response Relationship,

2005
Euphorigenic and abusive properties of modafinil.
    The American journal of psychiatry, 2006, Volume: 163, Issue:3

    Topics: Affective Symptoms; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorde

2006
Euphorigenic and abusive properties of modafinil.
    The American journal of psychiatry, 2006, Volume: 163, Issue:3

    Topics: Affective Symptoms; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorde

2006
Does modafinil produce euphoria?
    The American journal of psychiatry, 2006, Volume: 163, Issue:6

    Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorders; Euphoria; Humans

2006
Does modafinil produce euphoria?
    The American journal of psychiatry, 2006, Volume: 163, Issue:6

    Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorders; Euphoria; Humans

2006
Brain scans, genes provide addiction clues.
    JAMA, 2007, Apr-04, Volume: 297, Issue:13

    Topics: Benzhydryl Compounds; Brain; Brain Chemistry; Central Nervous System Agents; Humans; Modafinil; Mono

2007
Brain scans, genes provide addiction clues.
    JAMA, 2007, Apr-04, Volume: 297, Issue:13

    Topics: Benzhydryl Compounds; Brain; Brain Chemistry; Central Nervous System Agents; Humans; Modafinil; Mono

2007
Modafinil: mischaracterization.
    The Journal of clinical psychiatry, 2007, Volume: 68, Issue:6

    Topics: Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Central Nervous System Stimulan

2007
Modafinil: mischaracterization.
    The Journal of clinical psychiatry, 2007, Volume: 68, Issue:6

    Topics: Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Central Nervous System Stimulan

2007