modafinil has been researched along with Sensitivity and Specificity in 17 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The method was successfully applied to quantify ambrisentan concentrations in a rodent pharmacokinetic study after a single oral administration of ambrisentan at 2." | 1.38 | LC-ESI-MS/MS method for quantification of ambrisentan in plasma and application to rat pharmacokinetic study. ( Aleti, R; Kalaikadhiban, I; Kandikere, V; Komarneni, P; Nirogi, R; Padala, N, 2012) |
| "Modafinil is a wake-promoting drug effective at enhancing alertness and attention with a variety of approved and off-label applications." | 1.38 | Interactions between modafinil and cocaine during the induction of conditioned place preference and locomotor sensitization in mice: implications for addiction. ( Anagnostaras, SG; Cai, DJ; Sage, JR; Shuman, T, 2012) |
| "Modafinil acid was the major component in the urine, and was detected up to 4 days post-administration." | 1.33 | The detection of modafinil and its major metabolite in equine urine by liquid chromatography/mass spectrometry. ( McKinney, AR; Stenhouse, AM; Suann, CJ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 8 (47.06) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chandasana, H | 1 |
| Kast, J | 1 |
| Bittman, JA | 1 |
| Derendorf, H | 1 |
| Perkins, KA | 1 |
| Lerman, C | 1 |
| Karelitz, JL | 1 |
| Jao, NC | 1 |
| Chengappa, KN | 1 |
| Sparks, GM | 1 |
| Harvanová, M | 1 |
| Gondová, T | 1 |
| Rao, RN | 1 |
| Shinde, DD | 1 |
| Fujiki, N | 1 |
| Cheng, T | 1 |
| Yoshino, F | 1 |
| Nishino, S | 1 |
| Nirogi, R | 1 |
| Kandikere, V | 1 |
| Komarneni, P | 1 |
| Aleti, R | 1 |
| Padala, N | 1 |
| Kalaikadhiban, I | 1 |
| Shuman, T | 1 |
| Cai, DJ | 1 |
| Sage, JR | 1 |
| Anagnostaras, SG | 1 |
| Black, J | 1 |
| Pollak, CP | 1 |
| Pack, AI | 1 |
| McKinney, AR | 1 |
| Suann, CJ | 1 |
| Stenhouse, AM | 1 |
| Carrieri, PB | 1 |
| de Leva, MF | 1 |
| Carrieri, M | 1 |
| Buongiorno, M | 1 |
| Moachon, G | 1 |
| Matinier, D | 1 |
| Piérard, C | 1 |
| Satabin, P | 1 |
| Lagarde, D | 1 |
| Barrère, B | 1 |
| Guezennec, CY | 1 |
| Menu, JP | 1 |
| Pérès, M | 1 |
| Burnat, P | 1 |
| Robles, F | 1 |
| Do, B | 1 |
| Gorman, SH | 2 |
1 review available for modafinil and Sensitivity and Specificity
| Article | Year |
|---|---|
Should a pharmaceutical be approved for the broad indication of excessive sleepiness?
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Disorders of Excessive Somnolence; Drug App | 2003 |
16 other studies available for modafinil and Sensitivity and Specificity
| Article | Year |
|---|---|
Quantitative determination of armodafinil in human plasma by liquid chromatography-electrospray mass spectrometry: Application to a clinical study.
Topics: Benzhydryl Compounds; Chromatography, Liquid; Drug Stability; Humans; Linear Models; Modafinil; Repr | 2018 |
Sensitivity and specificity of a procedure for early human screening of novel smoking cessation medications.
Topics: Adult; Benzhydryl Compounds; Bupropion; Carbon Monoxide; Cross-Over Studies; Dopamine Uptake Inhibit | 2013 |
New enantioselective LC method development and validation for the assay of modafinil.
Topics: Benzhydryl Compounds; Biological Assay; Chromatography, High Pressure Liquid; Limit of Detection; Mo | 2017 |
Enantioselective separation and determination of adrafinil and modafinil on Chiralcel OJ-H column in rat serum and urine using solid-phase extraction followed by HPLC.
Topics: Animals; Benzhydryl Compounds; Calibration; Central Nervous System Stimulants; Chromatography, High | 2009 |
Specificity of direct transition from wake to REM sleep in orexin/ataxin-3 transgenic narcoleptic mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Ataxin-3; Benzhydryl Compounds; Cen | 2009 |
LC-ESI-MS/MS method for quantification of ambrisentan in plasma and application to rat pharmacokinetic study.
Topics: Animals; Area Under Curve; Benzhydryl Compounds; Chromatography, Liquid; Male; Modafinil; Phenylprop | 2012 |
Interactions between modafinil and cocaine during the induction of conditioned place preference and locomotor sensitization in mice: implications for addiction.
Topics: Animals; Benzhydryl Compounds; Central Nervous System Sensitization; Central Nervous System Stimulan | 2012 |
Pro: modafinil has a role in management of sleep apnea.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Controlled Clinical Trials as Topic; Female | 2003 |
Con: modafinil has no role in management of sleep apnea.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Controlled Clinical Trials as Topic; Female | 2003 |
The detection of modafinil and its major metabolite in equine urine by liquid chromatography/mass spectrometry.
Topics: Animals; Benzhydryl Compounds; Chromatography, Liquid; Doping in Sports; Horses; Modafinil; Molecula | 2005 |
Modafinil improves primary nocturnal enuresis in multiple sclerosis.
Topics: Adult; Benzhydryl Compounds; Central Nervous System; Central Nervous System Stimulants; Fatigue; Fem | 2007 |
Simultaneous determination of modafinil and its acid metabolite by high-performance liquid chromatography in human plasma.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Drug | 1994 |
Effects of a vigilance-enhancing drug, modafinil, on rat brain metabolism: a 2D COSY 1H-NMR study.
Topics: Animals; Aspartic Acid; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cognition; C | 1995 |
High-performance liquid chromatographic determination of modafinil and its two metabolites in human plasma using solid-phase extraction.
Topics: Administration, Oral; Benzhydryl Compounds; Calibration; Central Nervous System Stimulants; Chromato | 1998 |
Determination of the D- and L-enantiomers of modafinil in human plasma utilizing liquid-liquid extraction and high-performance liquid chromatography.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Human | 1999 |
Determination of modafinil, modafinil acid and modafinil sulfone in human plasma utilizing liquid-liquid extraction and high-performance liquid chromatography.
Topics: Benzhydryl Compounds; Chromatography, High Pressure Liquid; Humans; Modafinil; Reproducibility of Re | 2002 |